id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-325129-faptufak	Meini, Simone	Understanding the Pathophysiology of COVID-19: Could the Contact System Be the Key?	2020-08-11		.txt	text/plain	5501	255	38	Autoactivation of FXII by contact with SARS-CoV-2 could lead to activation of intrinsic coagulation, with fibrin formation (microthrombosis), and fibrinolysis, resulting in increased D-dimer levels. In this review, we try to address the complex link between the pathophysiology of COVID-19 and the different proteolytic defense systems operating in human vasculature, investigating the role of the mediators involved and speculating on the possibility of pharmacological modulation. After binding through its B2R, BK activates signaling pathways resulting in increased vascular permeability, vasodilation, edema formation, hypotension, pain, fever (14) : all typical clinical features of COVID-19. (79) hypothesized that a kinin-dependent local lung angioedema via B1R and eventually B2R is an important feature of COVID-19 and proposed that blocking the B2R and inhibiting plasma KAL activity might be beneficial in early disease, preventing ARDS.	./cache/cord-325129-faptufak.txt	./txt/cord-325129-faptufak.txt