id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-325353-tx6s4ggu	Restori, Katherine H.	Neonatal Immunity, Respiratory Virus Infections, and the Development of Asthma	2018-06-04		.txt	text/plain	13653	618	42	The goals of this review are (1) to outline the differences between the neonatal and adult immune systems and (2) to present murine and human data that support the hypothesis that early-life interactions between the immune system and respiratory viruses can create a lung environment conducive to the development of asthma. Because RSV, influenza, and RVs cause a large proportion of respiratorytract infections in neonates, we will focus primarily on these three pathogens as models to better understand how early-life infection and antiviral immune responses might contribute to the subsequent development of asthma. The addition of RSV infection of airway epithelial cells with production of the type-2 innate cytokines, IL-33 (138) , TSLP (123) , and IL-25 (128) , would, therefore, be predicted to create an even more exaggerated type-2-biased microenvironment in the lung with activation of other immune cells (e.g., M2 macrophages, DCs, and/or ILC2 cells) and the development of AHR.	./cache/cord-325353-tx6s4ggu.txt	./txt/cord-325353-tx6s4ggu.txt