id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-333932-aqcllik0	Diao, Bo	Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)	2020-05-01		.txt	text/plain	3822	179	50	Methods: We retrospectively reviewed the counts of T cells and serum cytokine concentration from data of 522 patients with laboratory-confirmed COVID-19 and 40 healthy controls. Our results thus provide a preliminary demonstration of T cell exhaustion during COVID-19 infection and suggest that more urgent, early intervention may be required in patients with low T lymphocyte counts. The expression of angiotensin converting enzyme 2 (ACE2), the predicted receptor of SARS-CoV-2 viruses, is absent on T cells (11) , suggesting that the depressed T counts in COVID-19 patients mentioned above (Figure 1 ) were likely not caused by direct infection of T cells. We demonstrate here that COVID-19 patients have very high levels of serum IL-10 following SARS-CoV-2 infection, while also displaying high levels of the PD-1 and Tim-3 exhaustion markers on their T cells, suggesting that IL-10 might be mechanistically responsible.	./cache/cord-333932-aqcllik0.txt	./txt/cord-333932-aqcllik0.txt