id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-338092-barmkkwx	Geginat, Jens	Immunity to Pathogens Taught by Specialized Human Dendritic Cell Subsets	2015-10-13		.txt	text/plain	8573	421	45	Upon viral infections, plasmacytoid DCs (pDCs) rapidly produce large amounts of IFN-α, which has potent antiviral functions and activates several other immune cells. BDCA-3(+) mDC2 are the human homologue of CD8α(+) mDCs, since they share the expression of several key molecules, the capacity to cross-present antigens to CD8(+) T-cells and to produce IFN-λ. Dendritic cells (DCs) can express very high levels of MHC and costimulatory molecules, and it is generally accepted that they are the relevant cells to induce the activation ("priming") of antigen-specific "naive" T cells (1, 2) and induce their differentiation into various types of effector T cells. Overall, these differences in pathogen sensing and T-cell activation between human and murine DCs are likely to have an important impact on their role in immune responses against specific pathogens. Dendritic cell subsets in humans and mice express not only different patterns of toll-like receptors, but they have also partially distinct cytokine profiles (Figure 1) .	./cache/cord-338092-barmkkwx.txt	./txt/cord-338092-barmkkwx.txt