id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-351431-xcqz9d3t	Wang, Jun	Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19	2020-08-18		.txt	text/plain	4522	268	48	Increasing neutrophil counts paralleled lesion CT values (slope: 0.8 and 0.3–1.2), reflecting neutrophilia-induced lung injury in severe patients. Transcriptome analysis revealed that neutrophil activation was correlated with 17 neutrophil extracellular trap (NET)-associated genes in COVID-19 patients, which was related to innate immunity and interacted with T/NK/B cells, as supported by a protein–protein interaction network analysis. Principal component analysis was performed with R package "FactoMineR" to identify those clinical parameters that contribute most to distinguishing severe, moderate, and mild cases of COVID-19 (28) . For BALF, the most upregulated marker genes were similarly enriched in neutrophils, but more up-regulated genes in monocytes and B cells were observed in COVID-19 patients compared to healthy controls, which is different from the lung samples. Transcriptome analysis of lung specimens and BALF from COVID-19 patients also indicated the most up-regulated marker genes were neutrophil related. Neutrophil extracellular traps (NETs) as markers of disease severity in COVID-19	./cache/cord-351431-xcqz9d3t.txt	./txt/cord-351431-xcqz9d3t.txt