id	sid	tid	token	lemma	pos
cord-283382-t890r7xp	1	1	key	key	JJ
cord-283382-t890r7xp	1	2	:	:	:
cord-283382-t890r7xp	1	3	cord-283382-t890r7xp	cord-283382-t890r7xp	CD
cord-283382-t890r7xp	1	4	authors	author	NNS
cord-283382-t890r7xp	1	5	:	:	:
cord-283382-t890r7xp	1	6	Coughlan	Coughlan	NNP
cord-283382-t890r7xp	1	7	,	,	,
cord-283382-t890r7xp	1	8	Lynda	Lynda	NNP
cord-283382-t890r7xp	1	9	title	title	NN
cord-283382-t890r7xp	1	10	:	:	:
cord-283382-t890r7xp	1	11	Factors	factor	NNS
cord-283382-t890r7xp	1	12	Which	which	WDT
cord-283382-t890r7xp	1	13	Contribute	contribute	VBP
cord-283382-t890r7xp	1	14	to	to	IN
cord-283382-t890r7xp	1	15	the	the	DT
cord-283382-t890r7xp	1	16	Immunogenicity	Immunogenicity	NNP
cord-283382-t890r7xp	1	17	of	of	IN
cord-283382-t890r7xp	1	18	Non	Non	NNP
cord-283382-t890r7xp	1	19	-	-	JJ
cord-283382-t890r7xp	1	20	replicating	replicate	VBG
cord-283382-t890r7xp	1	21	Adenoviral	Adenoviral	NNP
cord-283382-t890r7xp	1	22	Vectored	Vectored	NNP
cord-283382-t890r7xp	1	23	Vaccines	Vaccines	NNPS
cord-283382-t890r7xp	1	24	date	date	NN
cord-283382-t890r7xp	1	25	:	:	:
cord-283382-t890r7xp	1	26	2020	2020	CD
cord-283382-t890r7xp	1	27	-	-	HYPH
cord-283382-t890r7xp	1	28	05	05	CD
cord-283382-t890r7xp	1	29	-	-	HYPH
cord-283382-t890r7xp	1	30	19	19	CD
cord-283382-t890r7xp	1	31	journal	journal	NN
cord-283382-t890r7xp	1	32	:	:	:
cord-283382-t890r7xp	2	1	Front	Front	NNP
cord-283382-t890r7xp	2	2	Immunol	Immunol	NNP
cord-283382-t890r7xp	2	3	DOI	doi	NN
cord-283382-t890r7xp	2	4	:	:	:
cord-283382-t890r7xp	3	1	10.3389/	10.3389/	CD
cord-283382-t890r7xp	4	1	fimmu.2020.00909	fimmu.2020.00909	JJ
cord-283382-t890r7xp	5	1	sha	sha	NNP
cord-283382-t890r7xp	5	2	:	:	:
cord-283382-t890r7xp	5	3	31e8e86a9f6a489004a69ef7345ba9199669a07f	31e8e86a9f6a489004a69ef7345ba9199669a07f	CD
cord-283382-t890r7xp	5	4	doc_id	doc_id	CD
cord-283382-t890r7xp	5	5	:	:	:
cord-283382-t890r7xp	5	6	283382	283382	CD
cord-283382-t890r7xp	5	7	cord_uid	cord_uid	NNS
cord-283382-t890r7xp	5	8	:	:	:
cord-283382-t890r7xp	6	1	t890r7xp	t890r7xp	NNP
cord-283382-t890r7xp	6	2	Adenoviral	Adenoviral	NNP
cord-283382-t890r7xp	6	3	vectors	vector	NNS
cord-283382-t890r7xp	6	4	are	be	VBP
cord-283382-t890r7xp	6	5	a	a	DT
cord-283382-t890r7xp	6	6	safe	safe	JJ
cord-283382-t890r7xp	6	7	and	and	CC
cord-283382-t890r7xp	6	8	potently	potently	RB
cord-283382-t890r7xp	6	9	immunogenic	immunogenic	JJ
cord-283382-t890r7xp	6	10	vaccine	vaccine	NN
cord-283382-t890r7xp	6	11	delivery	delivery	NN
cord-283382-t890r7xp	6	12	platform	platform	NN
cord-283382-t890r7xp	6	13	.	.	.
cord-283382-t890r7xp	7	1	Non	non	JJ
cord-283382-t890r7xp	7	2	-	-	JJ
cord-283382-t890r7xp	7	3	replicating	replicate	VBG
cord-283382-t890r7xp	7	4	Ad	ad	NN
cord-283382-t890r7xp	7	5	vectors	vector	NNS
cord-283382-t890r7xp	7	6	possess	possess	VBP
cord-283382-t890r7xp	7	7	several	several	JJ
cord-283382-t890r7xp	7	8	attributes	attribute	NNS
cord-283382-t890r7xp	7	9	which	which	WDT
cord-283382-t890r7xp	7	10	make	make	VBP
cord-283382-t890r7xp	7	11	them	-PRON-	PRP
cord-283382-t890r7xp	7	12	attractive	attractive	JJ
cord-283382-t890r7xp	7	13	vaccines	vaccine	NNS
cord-283382-t890r7xp	7	14	for	for	IN
cord-283382-t890r7xp	7	15	infectious	infectious	JJ
cord-283382-t890r7xp	7	16	disease	disease	NN
cord-283382-t890r7xp	7	17	,	,	,
cord-283382-t890r7xp	7	18	including	include	VBG
cord-283382-t890r7xp	7	19	their	-PRON-	PRP$
cord-283382-t890r7xp	7	20	capacity	capacity	NN
cord-283382-t890r7xp	7	21	for	for	IN
cord-283382-t890r7xp	7	22	high	high	JJ
cord-283382-t890r7xp	7	23	titer	titer	NN
cord-283382-t890r7xp	7	24	growth	growth	NN
cord-283382-t890r7xp	7	25	,	,	,
cord-283382-t890r7xp	7	26	ease	ease	NN
cord-283382-t890r7xp	7	27	of	of	IN
cord-283382-t890r7xp	7	28	manipulation	manipulation	NN
cord-283382-t890r7xp	7	29	,	,	,
cord-283382-t890r7xp	7	30	safety	safety	NN
cord-283382-t890r7xp	7	31	,	,	,
cord-283382-t890r7xp	7	32	and	and	CC
cord-283382-t890r7xp	7	33	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	7	34	in	in	IN
cord-283382-t890r7xp	7	35	clinical	clinical	JJ
cord-283382-t890r7xp	7	36	studies	study	NNS
cord-283382-t890r7xp	7	37	,	,	,
cord-283382-t890r7xp	7	38	as	as	RB
cord-283382-t890r7xp	7	39	well	well	RB
cord-283382-t890r7xp	7	40	as	as	IN
cord-283382-t890r7xp	7	41	their	-PRON-	PRP$
cord-283382-t890r7xp	7	42	compatibility	compatibility	NN
cord-283382-t890r7xp	7	43	with	with	IN
cord-283382-t890r7xp	7	44	clinical	clinical	JJ
cord-283382-t890r7xp	7	45	manufacturing	manufacturing	NN
cord-283382-t890r7xp	7	46	and	and	CC
cord-283382-t890r7xp	7	47	thermo	thermo	NN
cord-283382-t890r7xp	7	48	-	-	HYPH
cord-283382-t890r7xp	7	49	stabilization	stabilization	NN
cord-283382-t890r7xp	7	50	procedures	procedure	NNS
cord-283382-t890r7xp	7	51	.	.	.
cord-283382-t890r7xp	8	1	In	in	IN
cord-283382-t890r7xp	8	2	general	general	JJ
cord-283382-t890r7xp	8	3	,	,	,
cord-283382-t890r7xp	8	4	Ad	ad	NN
cord-283382-t890r7xp	8	5	vectors	vector	NNS
cord-283382-t890r7xp	8	6	are	be	VBP
cord-283382-t890r7xp	8	7	immunogenic	immunogenic	JJ
cord-283382-t890r7xp	8	8	vaccines	vaccine	NNS
cord-283382-t890r7xp	8	9	,	,	,
cord-283382-t890r7xp	8	10	which	which	WDT
cord-283382-t890r7xp	8	11	elicit	elicit	VBP
cord-283382-t890r7xp	8	12	robust	robust	JJ
cord-283382-t890r7xp	8	13	transgene	transgene	NN
cord-283382-t890r7xp	8	14	antigen	antigen	NN
cord-283382-t890r7xp	8	15	-	-	HYPH
cord-283382-t890r7xp	8	16	specific	specific	JJ
cord-283382-t890r7xp	8	17	cellular	cellular	NN
cord-283382-t890r7xp	8	18	(	(	-LRB-
cord-283382-t890r7xp	8	19	namely	namely	RB
cord-283382-t890r7xp	8	20	CD8(+	CD8(+	NNP
cord-283382-t890r7xp	8	21	)	)	-RRB-
cord-283382-t890r7xp	8	22	T	t	NN
cord-283382-t890r7xp	8	23	cells	cell	NNS
cord-283382-t890r7xp	8	24	)	)	-RRB-
cord-283382-t890r7xp	8	25	and/or	and/or	CC
cord-283382-t890r7xp	8	26	humoral	humoral	JJ
cord-283382-t890r7xp	8	27	immune	immune	JJ
cord-283382-t890r7xp	8	28	responses	response	NNS
cord-283382-t890r7xp	8	29	.	.	.
cord-283382-t890r7xp	9	1	A	a	DT
cord-283382-t890r7xp	9	2	large	large	JJ
cord-283382-t890r7xp	9	3	number	number	NN
cord-283382-t890r7xp	9	4	of	of	IN
cord-283382-t890r7xp	9	5	adenoviruses	adenovirus	NNS
cord-283382-t890r7xp	9	6	isolated	isolate	VBN
cord-283382-t890r7xp	9	7	from	from	IN
cord-283382-t890r7xp	9	8	humans	human	NNS
cord-283382-t890r7xp	9	9	and	and	CC
cord-283382-t890r7xp	9	10	non	non	JJ
cord-283382-t890r7xp	9	11	-	-	JJ
cord-283382-t890r7xp	9	12	human	human	JJ
cord-283382-t890r7xp	9	13	primates	primate	NNS
cord-283382-t890r7xp	9	14	,	,	,
cord-283382-t890r7xp	9	15	which	which	WDT
cord-283382-t890r7xp	9	16	have	have	VBP
cord-283382-t890r7xp	9	17	low	low	JJ
cord-283382-t890r7xp	9	18	seroprevalence	seroprevalence	NN
cord-283382-t890r7xp	9	19	in	in	IN
cord-283382-t890r7xp	9	20	humans	human	NNS
cord-283382-t890r7xp	9	21	,	,	,
cord-283382-t890r7xp	9	22	have	have	VBP
cord-283382-t890r7xp	9	23	been	be	VBN
cord-283382-t890r7xp	9	24	vectorized	vectorize	VBN
cord-283382-t890r7xp	9	25	and	and	CC
cord-283382-t890r7xp	9	26	tested	test	VBN
cord-283382-t890r7xp	9	27	as	as	IN
cord-283382-t890r7xp	9	28	vaccines	vaccine	NNS
cord-283382-t890r7xp	9	29	in	in	IN
cord-283382-t890r7xp	9	30	animal	animal	NN
cord-283382-t890r7xp	9	31	models	model	NNS
cord-283382-t890r7xp	9	32	and	and	CC
cord-283382-t890r7xp	9	33	humans	human	NNS
cord-283382-t890r7xp	9	34	.	.	.
cord-283382-t890r7xp	10	1	However	however	RB
cord-283382-t890r7xp	10	2	,	,	,
cord-283382-t890r7xp	10	3	a	a	DT
cord-283382-t890r7xp	10	4	distinct	distinct	JJ
cord-283382-t890r7xp	10	5	hierarchy	hierarchy	NN
cord-283382-t890r7xp	10	6	of	of	IN
cord-283382-t890r7xp	10	7	immunological	immunological	JJ
cord-283382-t890r7xp	10	8	potency	potency	NN
cord-283382-t890r7xp	10	9	has	have	VBZ
cord-283382-t890r7xp	10	10	been	be	VBN
cord-283382-t890r7xp	10	11	identified	identify	VBN
cord-283382-t890r7xp	10	12	between	between	IN
cord-283382-t890r7xp	10	13	diverse	diverse	JJ
cord-283382-t890r7xp	10	14	Ad	ad	NN
cord-283382-t890r7xp	10	15	vectors	vector	NNS
cord-283382-t890r7xp	10	16	,	,	,
cord-283382-t890r7xp	10	17	which	which	WDT
cord-283382-t890r7xp	10	18	unfortunately	unfortunately	RB
cord-283382-t890r7xp	10	19	limits	limit	VBZ
cord-283382-t890r7xp	10	20	the	the	DT
cord-283382-t890r7xp	10	21	potential	potential	JJ
cord-283382-t890r7xp	10	22	use	use	NN
cord-283382-t890r7xp	10	23	of	of	IN
cord-283382-t890r7xp	10	24	many	many	JJ
cord-283382-t890r7xp	10	25	vectors	vector	NNS
cord-283382-t890r7xp	10	26	which	which	WDT
cord-283382-t890r7xp	10	27	have	have	VBP
cord-283382-t890r7xp	10	28	otherwise	otherwise	RB
cord-283382-t890r7xp	10	29	desirable	desirable	JJ
cord-283382-t890r7xp	10	30	manufacturing	manufacturing	NN
cord-283382-t890r7xp	10	31	characteristics	characteristic	NNS
cord-283382-t890r7xp	10	32	.	.	.
cord-283382-t890r7xp	11	1	The	the	DT
cord-283382-t890r7xp	11	2	precise	precise	JJ
cord-283382-t890r7xp	11	3	mechanistic	mechanistic	JJ
cord-283382-t890r7xp	11	4	factors	factor	NNS
cord-283382-t890r7xp	11	5	which	which	WDT
cord-283382-t890r7xp	11	6	underlie	underlie	VBP
cord-283382-t890r7xp	11	7	the	the	DT
cord-283382-t890r7xp	11	8	profound	profound	JJ
cord-283382-t890r7xp	11	9	disparities	disparity	NNS
cord-283382-t890r7xp	11	10	in	in	IN
cord-283382-t890r7xp	11	11	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	11	12	are	be	VBP
cord-283382-t890r7xp	11	13	not	not	RB
cord-283382-t890r7xp	11	14	clearly	clearly	RB
cord-283382-t890r7xp	11	15	defined	define	VBN
cord-283382-t890r7xp	11	16	and	and	CC
cord-283382-t890r7xp	11	17	are	be	VBP
cord-283382-t890r7xp	11	18	the	the	DT
cord-283382-t890r7xp	11	19	subject	subject	NN
cord-283382-t890r7xp	11	20	of	of	IN
cord-283382-t890r7xp	11	21	ongoing	ongoing	JJ
cord-283382-t890r7xp	11	22	,	,	,
cord-283382-t890r7xp	11	23	detailed	detailed	JJ
cord-283382-t890r7xp	11	24	investigation	investigation	NN
cord-283382-t890r7xp	11	25	.	.	.
cord-283382-t890r7xp	12	1	It	-PRON-	PRP
cord-283382-t890r7xp	12	2	has	have	VBZ
cord-283382-t890r7xp	12	3	been	be	VBN
cord-283382-t890r7xp	12	4	suggested	suggest	VBN
cord-283382-t890r7xp	12	5	that	that	IN
cord-283382-t890r7xp	12	6	a	a	DT
cord-283382-t890r7xp	12	7	combination	combination	NN
cord-283382-t890r7xp	12	8	of	of	IN
cord-283382-t890r7xp	12	9	factors	factor	NNS
cord-283382-t890r7xp	12	10	contribute	contribute	VBP
cord-283382-t890r7xp	12	11	to	to	IN
cord-283382-t890r7xp	12	12	the	the	DT
cord-283382-t890r7xp	12	13	potent	potent	JJ
cord-283382-t890r7xp	12	14	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	12	15	of	of	IN
cord-283382-t890r7xp	12	16	particular	particular	JJ
cord-283382-t890r7xp	12	17	Ad	ad	NN
cord-283382-t890r7xp	12	18	vectors	vector	NNS
cord-283382-t890r7xp	12	19	,	,	,
cord-283382-t890r7xp	12	20	including	include	VBG
cord-283382-t890r7xp	12	21	the	the	DT
cord-283382-t890r7xp	12	22	magnitude	magnitude	NN
cord-283382-t890r7xp	12	23	and	and	CC
cord-283382-t890r7xp	12	24	duration	duration	NN
cord-283382-t890r7xp	12	25	of	of	IN
cord-283382-t890r7xp	12	26	vaccine	vaccine	NN
cord-283382-t890r7xp	12	27	antigen	antigen	NN
cord-283382-t890r7xp	12	28	expression	expression	NN
cord-283382-t890r7xp	12	29	following	follow	VBG
cord-283382-t890r7xp	12	30	immunization	immunization	NN
cord-283382-t890r7xp	12	31	.	.	.
cord-283382-t890r7xp	13	1	Furthermore	furthermore	RB
cord-283382-t890r7xp	13	2	,	,	,
cord-283382-t890r7xp	13	3	the	the	DT
cord-283382-t890r7xp	13	4	excessive	excessive	JJ
cord-283382-t890r7xp	13	5	induction	induction	NN
cord-283382-t890r7xp	13	6	of	of	IN
cord-283382-t890r7xp	13	7	Type	type	NN
cord-283382-t890r7xp	13	8	I	-PRON-	PRP
cord-283382-t890r7xp	13	9	interferons	interferon	NNS
cord-283382-t890r7xp	13	10	by	by	IN
cord-283382-t890r7xp	13	11	some	some	DT
cord-283382-t890r7xp	13	12	Ad	ad	NN
cord-283382-t890r7xp	13	13	vectors	vector	NNS
cord-283382-t890r7xp	13	14	has	have	VBZ
cord-283382-t890r7xp	13	15	been	be	VBN
cord-283382-t890r7xp	13	16	suggested	suggest	VBN
cord-283382-t890r7xp	13	17	to	to	TO
cord-283382-t890r7xp	13	18	impair	impair	VB
cord-283382-t890r7xp	13	19	transgene	transgene	JJ
cord-283382-t890r7xp	13	20	expression	expression	NN
cord-283382-t890r7xp	13	21	levels	level	NNS
cord-283382-t890r7xp	13	22	,	,	,
cord-283382-t890r7xp	13	23	dampening	dampen	VBG
cord-283382-t890r7xp	13	24	subsequent	subsequent	JJ
cord-283382-t890r7xp	13	25	immune	immune	JJ
cord-283382-t890r7xp	13	26	responses	response	NNS
cord-283382-t890r7xp	13	27	.	.	.
cord-283382-t890r7xp	14	1	Therefore	therefore	RB
cord-283382-t890r7xp	14	2	,	,	,
cord-283382-t890r7xp	14	3	the	the	DT
cord-283382-t890r7xp	14	4	induction	induction	NN
cord-283382-t890r7xp	14	5	of	of	IN
cord-283382-t890r7xp	14	6	balanced	balanced	JJ
cord-283382-t890r7xp	14	7	,	,	,
cord-283382-t890r7xp	14	8	but	but	CC
cord-283382-t890r7xp	14	9	not	not	RB
cord-283382-t890r7xp	14	10	excessive	excessive	JJ
cord-283382-t890r7xp	14	11	stimulation	stimulation	NN
cord-283382-t890r7xp	14	12	of	of	IN
cord-283382-t890r7xp	14	13	innate	innate	JJ
cord-283382-t890r7xp	14	14	signaling	signaling	NN
cord-283382-t890r7xp	14	15	is	be	VBZ
cord-283382-t890r7xp	14	16	optimal	optimal	JJ
cord-283382-t890r7xp	14	17	.	.	.
cord-283382-t890r7xp	15	1	Entry	entry	NN
cord-283382-t890r7xp	15	2	factor	factor	NN
cord-283382-t890r7xp	15	3	binding	bind	VBG
cord-283382-t890r7xp	15	4	or	or	CC
cord-283382-t890r7xp	15	5	receptor	receptor	NN
cord-283382-t890r7xp	15	6	usage	usage	NN
cord-283382-t890r7xp	15	7	of	of	IN
cord-283382-t890r7xp	15	8	distinct	distinct	JJ
cord-283382-t890r7xp	15	9	Ad	ad	NN
cord-283382-t890r7xp	15	10	vectors	vector	NNS
cord-283382-t890r7xp	15	11	can	can	MD
cord-283382-t890r7xp	15	12	also	also	RB
cord-283382-t890r7xp	15	13	affect	affect	VB
cord-283382-t890r7xp	15	14	their	-PRON-	PRP$
cord-283382-t890r7xp	15	15	in	in	IN
cord-283382-t890r7xp	15	16	vivo	vivo	NN
cord-283382-t890r7xp	15	17	tropism	tropism	NN
cord-283382-t890r7xp	15	18	following	follow	VBG
cord-283382-t890r7xp	15	19	administration	administration	NN
cord-283382-t890r7xp	15	20	by	by	IN
cord-283382-t890r7xp	15	21	different	different	JJ
cord-283382-t890r7xp	15	22	routes	route	NNS
cord-283382-t890r7xp	15	23	.	.	.
cord-283382-t890r7xp	16	1	The	the	DT
cord-283382-t890r7xp	16	2	abundance	abundance	NN
cord-283382-t890r7xp	16	3	and	and	CC
cord-283382-t890r7xp	16	4	accessibility	accessibility	NN
cord-283382-t890r7xp	16	5	of	of	IN
cord-283382-t890r7xp	16	6	innate	innate	JJ
cord-283382-t890r7xp	16	7	immune	immune	JJ
cord-283382-t890r7xp	16	8	cells	cell	NNS
cord-283382-t890r7xp	16	9	and/or	and/or	CC
cord-283382-t890r7xp	16	10	antigen	antigen	NN
cord-283382-t890r7xp	16	11	-	-	HYPH
cord-283382-t890r7xp	16	12	presenting	present	VBG
cord-283382-t890r7xp	16	13	cells	cell	NNS
cord-283382-t890r7xp	16	14	at	at	IN
cord-283382-t890r7xp	16	15	the	the	DT
cord-283382-t890r7xp	16	16	site	site	NN
cord-283382-t890r7xp	16	17	of	of	IN
cord-283382-t890r7xp	16	18	injection	injection	NN
cord-283382-t890r7xp	16	19	contributes	contribute	VBZ
cord-283382-t890r7xp	16	20	to	to	IN
cord-283382-t890r7xp	16	21	early	early	JJ
cord-283382-t890r7xp	16	22	innate	innate	JJ
cord-283382-t890r7xp	16	23	immune	immune	JJ
cord-283382-t890r7xp	16	24	responses	response	NNS
cord-283382-t890r7xp	16	25	to	to	IN
cord-283382-t890r7xp	16	26	Ad	ad	NN
cord-283382-t890r7xp	16	27	vaccination	vaccination	NN
cord-283382-t890r7xp	16	28	,	,	,
cord-283382-t890r7xp	16	29	affecting	affect	VBG
cord-283382-t890r7xp	16	30	the	the	DT
cord-283382-t890r7xp	16	31	outcome	outcome	NN
cord-283382-t890r7xp	16	32	of	of	IN
cord-283382-t890r7xp	16	33	the	the	DT
cord-283382-t890r7xp	16	34	adaptive	adaptive	JJ
cord-283382-t890r7xp	16	35	immune	immune	JJ
cord-283382-t890r7xp	16	36	response	response	NN
cord-283382-t890r7xp	16	37	.	.	.
cord-283382-t890r7xp	17	1	Although	although	IN
cord-283382-t890r7xp	17	2	a	a	DT
cord-283382-t890r7xp	17	3	significant	significant	JJ
cord-283382-t890r7xp	17	4	amount	amount	NN
cord-283382-t890r7xp	17	5	of	of	IN
cord-283382-t890r7xp	17	6	information	information	NN
cord-283382-t890r7xp	17	7	exists	exist	VBZ
cord-283382-t890r7xp	17	8	regarding	regard	VBG
cord-283382-t890r7xp	17	9	the	the	DT
cord-283382-t890r7xp	17	10	tropism	tropism	NN
cord-283382-t890r7xp	17	11	determinants	determinant	NNS
cord-283382-t890r7xp	17	12	of	of	IN
cord-283382-t890r7xp	17	13	the	the	DT
cord-283382-t890r7xp	17	14	common	common	JJ
cord-283382-t890r7xp	17	15	human	human	JJ
cord-283382-t890r7xp	17	16	adenovirus	adenovirus	NN
cord-283382-t890r7xp	17	17	type-5	type-5	IN
cord-283382-t890r7xp	17	18	vector	vector	NN
cord-283382-t890r7xp	17	19	,	,	,
cord-283382-t890r7xp	17	20	very	very	RB
cord-283382-t890r7xp	17	21	little	little	JJ
cord-283382-t890r7xp	17	22	is	be	VBZ
cord-283382-t890r7xp	17	23	known	know	VBN
cord-283382-t890r7xp	17	24	about	about	IN
cord-283382-t890r7xp	17	25	the	the	DT
cord-283382-t890r7xp	17	26	receptor	receptor	NN
cord-283382-t890r7xp	17	27	usage	usage	NN
cord-283382-t890r7xp	17	28	and	and	CC
cord-283382-t890r7xp	17	29	tropism	tropism	NN
cord-283382-t890r7xp	17	30	of	of	IN
cord-283382-t890r7xp	17	31	rare	rare	JJ
cord-283382-t890r7xp	17	32	species	specie	NNS
cord-283382-t890r7xp	17	33	or	or	CC
cord-283382-t890r7xp	17	34	non	non	JJ
cord-283382-t890r7xp	17	35	-	-	JJ
cord-283382-t890r7xp	17	36	human	human	JJ
cord-283382-t890r7xp	17	37	Ad	ad	NN
cord-283382-t890r7xp	17	38	vectors	vector	NNS
cord-283382-t890r7xp	17	39	.	.	.
cord-283382-t890r7xp	18	1	Increased	increase	VBN
cord-283382-t890r7xp	18	2	understanding	understanding	NN
cord-283382-t890r7xp	18	3	of	of	IN
cord-283382-t890r7xp	18	4	how	how	WRB
cord-283382-t890r7xp	18	5	different	different	JJ
cord-283382-t890r7xp	18	6	facets	facet	NNS
cord-283382-t890r7xp	18	7	of	of	IN
cord-283382-t890r7xp	18	8	the	the	DT
cord-283382-t890r7xp	18	9	host	host	NN
cord-283382-t890r7xp	18	10	response	response	NN
cord-283382-t890r7xp	18	11	to	to	IN
cord-283382-t890r7xp	18	12	Ad	ad	NN
cord-283382-t890r7xp	18	13	vectors	vector	NNS
cord-283382-t890r7xp	18	14	contribute	contribute	VBP
cord-283382-t890r7xp	18	15	to	to	IN
cord-283382-t890r7xp	18	16	their	-PRON-	PRP$
cord-283382-t890r7xp	18	17	immunological	immunological	JJ
cord-283382-t890r7xp	18	18	potency	potency	NN
cord-283382-t890r7xp	18	19	will	will	MD
cord-283382-t890r7xp	18	20	be	be	VB
cord-283382-t890r7xp	18	21	essential	essential	JJ
cord-283382-t890r7xp	18	22	for	for	IN
cord-283382-t890r7xp	18	23	the	the	DT
cord-283382-t890r7xp	18	24	development	development	NN
cord-283382-t890r7xp	18	25	of	of	IN
cord-283382-t890r7xp	18	26	optimized	optimize	VBN
cord-283382-t890r7xp	18	27	and	and	CC
cord-283382-t890r7xp	18	28	customized	customize	VBN
cord-283382-t890r7xp	18	29	Ad	ad	NN
cord-283382-t890r7xp	18	30	vaccine	vaccine	NN
cord-283382-t890r7xp	18	31	platforms	platform	NNS
cord-283382-t890r7xp	18	32	for	for	IN
cord-283382-t890r7xp	18	33	specific	specific	JJ
cord-283382-t890r7xp	18	34	diseases	disease	NNS
cord-283382-t890r7xp	18	35	.	.	.
cord-283382-t890r7xp	19	1	Adenoviruses	adenovirus	NNS
cord-283382-t890r7xp	19	2	(	(	-LRB-
cord-283382-t890r7xp	19	3	Ad	ad	NN
cord-283382-t890r7xp	19	4	)	)	-RRB-
cord-283382-t890r7xp	19	5	represent	represent	VBP
cord-283382-t890r7xp	19	6	a	a	DT
cord-283382-t890r7xp	19	7	promising	promising	JJ
cord-283382-t890r7xp	19	8	vector	vector	NN
cord-283382-t890r7xp	19	9	platform	platform	NN
cord-283382-t890r7xp	19	10	for	for	IN
cord-283382-t890r7xp	19	11	the	the	DT
cord-283382-t890r7xp	19	12	development	development	NN
cord-283382-t890r7xp	19	13	of	of	IN
cord-283382-t890r7xp	19	14	vaccines	vaccine	NNS
cord-283382-t890r7xp	19	15	for	for	IN
cord-283382-t890r7xp	19	16	infectious	infectious	JJ
cord-283382-t890r7xp	19	17	disease	disease	NN
cord-283382-t890r7xp	19	18	,	,	,
cord-283382-t890r7xp	19	19	largely	largely	RB
cord-283382-t890r7xp	19	20	due	due	JJ
cord-283382-t890r7xp	19	21	to	to	IN
cord-283382-t890r7xp	19	22	their	-PRON-	PRP$
cord-283382-t890r7xp	19	23	safety	safety	NN
cord-283382-t890r7xp	19	24	and	and	CC
cord-283382-t890r7xp	19	25	ability	ability	NN
cord-283382-t890r7xp	19	26	to	to	TO
cord-283382-t890r7xp	19	27	stimulate	stimulate	VB
cord-283382-t890r7xp	19	28	robust	robust	JJ
cord-283382-t890r7xp	19	29	cellular	cellular	JJ
cord-283382-t890r7xp	19	30	and/or	and/or	CC
cord-283382-t890r7xp	19	31	humoral	humoral	JJ
cord-283382-t890r7xp	19	32	immune	immune	JJ
cord-283382-t890r7xp	19	33	responses	response	NNS
cord-283382-t890r7xp	19	34	in	in	IN
cord-283382-t890r7xp	19	35	multiple	multiple	JJ
cord-283382-t890r7xp	19	36	species	specie	NNS
cord-283382-t890r7xp	19	37	(	(	-LRB-
cord-283382-t890r7xp	19	38	1	1	CD
cord-283382-t890r7xp	19	39	)	)	-RRB-
cord-283382-t890r7xp	19	40	(	(	-LRB-
cord-283382-t890r7xp	19	41	2	2	LS
cord-283382-t890r7xp	19	42	)	)	-RRB-
cord-283382-t890r7xp	19	43	(	(	-LRB-
cord-283382-t890r7xp	19	44	3	3	LS
cord-283382-t890r7xp	19	45	)	)	-RRB-
cord-283382-t890r7xp	19	46	(	(	-LRB-
cord-283382-t890r7xp	19	47	4	4	LS
cord-283382-t890r7xp	19	48	)	)	-RRB-
cord-283382-t890r7xp	19	49	(	(	-LRB-
cord-283382-t890r7xp	19	50	5	5	LS
cord-283382-t890r7xp	19	51	)	)	-RRB-
cord-283382-t890r7xp	19	52	(	(	-LRB-
cord-283382-t890r7xp	19	53	6	6	LS
cord-283382-t890r7xp	19	54	)	)	-RRB-
cord-283382-t890r7xp	19	55	(	(	-LRB-
cord-283382-t890r7xp	19	56	7	7	LS
cord-283382-t890r7xp	19	57	)	)	-RRB-
cord-283382-t890r7xp	19	58	(	(	-LRB-
cord-283382-t890r7xp	19	59	8)	8)	NNP
cord-283382-t890r7xp	19	60	,	,	,
cord-283382-t890r7xp	19	61	as	as	IN
cord-283382-t890r7xp	19	62	compared	compare	VBN
cord-283382-t890r7xp	19	63	with	with	IN
cord-283382-t890r7xp	19	64	other	other	JJ
cord-283382-t890r7xp	19	65	genetic	genetic	JJ
cord-283382-t890r7xp	19	66	vaccine	vaccine	NN
cord-283382-t890r7xp	19	67	platforms	platform	NNS
cord-283382-t890r7xp	19	68	(	(	-LRB-
cord-283382-t890r7xp	19	69	5	5	CD
cord-283382-t890r7xp	19	70	,	,	,
cord-283382-t890r7xp	19	71	(	(	-LRB-
cord-283382-t890r7xp	19	72	9	9	LS
cord-283382-t890r7xp	19	73	)	)	-RRB-
cord-283382-t890r7xp	19	74	(	(	-LRB-
cord-283382-t890r7xp	19	75	10	10	CD
cord-283382-t890r7xp	19	76	)	)	-RRB-
cord-283382-t890r7xp	19	77	(	(	-LRB-
cord-283382-t890r7xp	19	78	11	11	CD
cord-283382-t890r7xp	19	79	)	)	-RRB-
cord-283382-t890r7xp	19	80	(	(	-LRB-
cord-283382-t890r7xp	19	81	12	12	CD
cord-283382-t890r7xp	19	82	)	)	-RRB-
cord-283382-t890r7xp	19	83	.	.	.
cord-283382-t890r7xp	20	1	Adenoviruses	adenovirus	NNS
cord-283382-t890r7xp	20	2	derived	derive	VBN
cord-283382-t890r7xp	20	3	from	from	IN
cord-283382-t890r7xp	20	4	humans	human	NNS
cord-283382-t890r7xp	20	5	and	and	CC
cord-283382-t890r7xp	20	6	non	non	JJ
cord-283382-t890r7xp	20	7	-	-	JJ
cord-283382-t890r7xp	20	8	human	human	JJ
cord-283382-t890r7xp	20	9	primates	primate	NNS
cord-283382-t890r7xp	20	10	(	(	-LRB-
cord-283382-t890r7xp	20	11	NHP	NHP	NNP
cord-283382-t890r7xp	20	12	)	)	-RRB-
cord-283382-t890r7xp	20	13	belong	belong	VBP
cord-283382-t890r7xp	20	14	to	to	IN
cord-283382-t890r7xp	20	15	the	the	DT
cord-283382-t890r7xp	20	16	family	family	NN
cord-283382-t890r7xp	20	17	Adenoviridae	Adenoviridae	NNP
cord-283382-t890r7xp	20	18	and	and	CC
cord-283382-t890r7xp	20	19	the	the	DT
cord-283382-t890r7xp	20	20	genus	genus	NN
cord-283382-t890r7xp	20	21	Mastadenoviridae	Mastadenoviridae	NNP
cord-283382-t890r7xp	20	22	,	,	,
cord-283382-t890r7xp	20	23	and	and	CC
cord-283382-t890r7xp	20	24	are	be	VBP
cord-283382-t890r7xp	20	25	further	further	RB
cord-283382-t890r7xp	20	26	subdivided	subdivide	VBN
cord-283382-t890r7xp	20	27	into	into	IN
cord-283382-t890r7xp	20	28	species	specie	NNS
cord-283382-t890r7xp	20	29	A	a	NN
cord-283382-t890r7xp	20	30	-	-	HYPH
cord-283382-t890r7xp	20	31	G	g	NN
cord-283382-t890r7xp	20	32	(	(	-LRB-
cord-283382-t890r7xp	20	33	i.e.	i.e.	FW
cord-283382-t890r7xp	20	34	,	,	,
cord-283382-t890r7xp	20	35	for	for	IN
cord-283382-t890r7xp	20	36	species	specie	NNS
cord-283382-t890r7xp	21	1	A	a	DT
cord-283382-t890r7xp	21	2	viruses	virus	NNS
cord-283382-t890r7xp	22	1	,	,	,
cord-283382-t890r7xp	22	2	these	these	DT
cord-283382-t890r7xp	22	3	are	be	VBP
cord-283382-t890r7xp	22	4	denoted	denote	VBN
cord-283382-t890r7xp	22	5	HAdV	HAdV	NNP
cord-283382-t890r7xp	22	6	-	-	HYPH
cord-283382-t890r7xp	22	7	A	A	NNP
cord-283382-t890r7xp	22	8	followed	follow	VBN
cord-283382-t890r7xp	22	9	by	by	IN
cord-283382-t890r7xp	22	10	the	the	DT
cord-283382-t890r7xp	22	11	type	type	NN
cord-283382-t890r7xp	22	12	number	number	NN
cord-283382-t890r7xp	22	13	)	)	-RRB-
cord-283382-t890r7xp	22	14	.	.	.
cord-283382-t890r7xp	23	1	Accounting	account	VBG
cord-283382-t890r7xp	23	2	for	for	IN
cord-283382-t890r7xp	23	3	the	the	DT
cord-283382-t890r7xp	23	4	inclusion	inclusion	NN
cord-283382-t890r7xp	23	5	of	of	IN
cord-283382-t890r7xp	23	6	many	many	JJ
cord-283382-t890r7xp	23	7	Ad	ad	NN
cord-283382-t890r7xp	23	8	recombinants	recombinant	NNS
cord-283382-t890r7xp	23	9	(	(	-LRB-
cord-283382-t890r7xp	23	10	13	13	CD
cord-283382-t890r7xp	23	11	,	,	,
cord-283382-t890r7xp	23	12	14	14	CD
cord-283382-t890r7xp	23	13	)	)	-RRB-
cord-283382-t890r7xp	23	14	,	,	,
cord-283382-t890r7xp	23	15	∼103	∼103	NNP
cord-283382-t890r7xp	23	16	human	human	JJ
cord-283382-t890r7xp	23	17	Ads	ad	NNS
cord-283382-t890r7xp	23	18	(	(	-LRB-
cord-283382-t890r7xp	23	19	http://hadvwg.gmu	http://hadvwg.gmu	ADD
cord-283382-t890r7xp	23	20	.	.	.
cord-283382-t890r7xp	23	21	edu/	edu/	LS
cord-283382-t890r7xp	23	22	)	)	-RRB-
cord-283382-t890r7xp	24	1	and	and	CC
cord-283382-t890r7xp	24	2	>	>	XX
cord-283382-t890r7xp	24	3	200	200	CD
cord-283382-t890r7xp	24	4	non	non	JJ
cord-283382-t890r7xp	24	5	-	-	JJ
cord-283382-t890r7xp	24	6	human	human	JJ
cord-283382-t890r7xp	24	7	Ad	ad	NN
cord-283382-t890r7xp	24	8	serotypes	serotype	NNS
cord-283382-t890r7xp	24	9	have	have	VBP
cord-283382-t890r7xp	24	10	been	be	VBN
cord-283382-t890r7xp	24	11	identified	identify	VBN
cord-283382-t890r7xp	24	12	to	to	IN
cord-283382-t890r7xp	24	13	date	date	NN
cord-283382-t890r7xp	24	14	.	.	.
cord-283382-t890r7xp	25	1	Adenoviruses	adenovirus	NNS
cord-283382-t890r7xp	25	2	are	be	VBP
cord-283382-t890r7xp	25	3	non	non	JJ
cord-283382-t890r7xp	25	4	-	-	JJ
cord-283382-t890r7xp	25	5	enveloped	enveloped	JJ
cord-283382-t890r7xp	25	6	viruses	virus	NNS
cord-283382-t890r7xp	25	7	which	which	WDT
cord-283382-t890r7xp	25	8	contain	contain	VBP
cord-283382-t890r7xp	25	9	a	a	DT
cord-283382-t890r7xp	25	10	double	double	RB
cord-283382-t890r7xp	25	11	-	-	HYPH
cord-283382-t890r7xp	25	12	stranded	strand	VBN
cord-283382-t890r7xp	25	13	DNA	dna	NN
cord-283382-t890r7xp	25	14	genome	genome	NN
cord-283382-t890r7xp	25	15	.	.	.
cord-283382-t890r7xp	26	1	The	the	DT
cord-283382-t890r7xp	26	2	virion	virion	NN
cord-283382-t890r7xp	26	3	exterior	exterior	NN
cord-283382-t890r7xp	26	4	is	be	VBZ
cord-283382-t890r7xp	26	5	composed	compose	VBN
cord-283382-t890r7xp	26	6	of	of	IN
cord-283382-t890r7xp	26	7	three	three	CD
cord-283382-t890r7xp	26	8	major	major	JJ
cord-283382-t890r7xp	26	9	structural	structural	JJ
cord-283382-t890r7xp	26	10	proteins	protein	NNS
cord-283382-t890r7xp	26	11	,	,	,
cord-283382-t890r7xp	26	12	the	the	DT
cord-283382-t890r7xp	26	13	fiber	fiber	NN
cord-283382-t890r7xp	26	14	,	,	,
cord-283382-t890r7xp	26	15	the	the	DT
cord-283382-t890r7xp	26	16	penton	penton	NNP
cord-283382-t890r7xp	26	17	base	base	NNP
cord-283382-t890r7xp	26	18	and	and	CC
cord-283382-t890r7xp	26	19	the	the	DT
cord-283382-t890r7xp	26	20	hexon	hexon	NN
cord-283382-t890r7xp	26	21	[	[	-LRB-
cord-283382-t890r7xp	26	22	(	(	-LRB-
cord-283382-t890r7xp	26	23	15	15	CD
cord-283382-t890r7xp	26	24	)	)	-RRB-
cord-283382-t890r7xp	26	25	(	(	-LRB-
cord-283382-t890r7xp	26	26	16	16	CD
cord-283382-t890r7xp	26	27	)	)	-RRB-
cord-283382-t890r7xp	26	28	(	(	-LRB-
cord-283382-t890r7xp	26	29	17	17	CD
cord-283382-t890r7xp	26	30	)	)	-RRB-
cord-283382-t890r7xp	26	31	(	(	-LRB-
cord-283382-t890r7xp	26	32	18	18	CD
cord-283382-t890r7xp	26	33	)	)	-RRB-
cord-283382-t890r7xp	26	34	;	;	:
cord-283382-t890r7xp	26	35	Figure	figure	NN
cord-283382-t890r7xp	26	36	1	1	CD
cord-283382-t890r7xp	26	37	]	]	-RRB-
cord-283382-t890r7xp	26	38	.	.	.
cord-283382-t890r7xp	27	1	Recombinant	Recombinant	NNP
cord-283382-t890r7xp	27	2	Ad	Ad	NNP
cord-283382-t890r7xp	27	3	(	(	-LRB-
cord-283382-t890r7xp	27	4	rAd	rAd	NNP
cord-283382-t890r7xp	27	5	)	)	-RRB-
cord-283382-t890r7xp	27	6	vectors	vector	NNS
cord-283382-t890r7xp	27	7	can	can	MD
cord-283382-t890r7xp	27	8	easily	easily	RB
cord-283382-t890r7xp	27	9	be	be	VB
cord-283382-t890r7xp	27	10	rendered	render	VBN
cord-283382-t890r7xp	27	11	replication	replication	NN
cord-283382-t890r7xp	27	12	-	-	HYPH
cord-283382-t890r7xp	27	13	incompetent	incompetent	JJ
cord-283382-t890r7xp	27	14	(	(	-LRB-
cord-283382-t890r7xp	27	15	non	non	JJ
cord-283382-t890r7xp	27	16	-	-	JJ
cord-283382-t890r7xp	27	17	replicating	replicating	JJ
cord-283382-t890r7xp	27	18	)	)	-RRB-
cord-283382-t890r7xp	27	19	through	through	IN
cord-283382-t890r7xp	27	20	deletion	deletion	NN
cord-283382-t890r7xp	27	21	of	of	IN
cord-283382-t890r7xp	27	22	the	the	DT
cord-283382-t890r7xp	27	23	essential	essential	JJ
cord-283382-t890r7xp	27	24	viral	viral	JJ
cord-283382-t890r7xp	27	25	gene	gene	NN
cord-283382-t890r7xp	27	26	E1	e1	NN
cord-283382-t890r7xp	27	27	from	from	IN
cord-283382-t890r7xp	27	28	their	-PRON-	PRP$
cord-283382-t890r7xp	27	29	genome	genome	NN
cord-283382-t890r7xp	27	30	and	and	CC
cord-283382-t890r7xp	27	31	can	can	MD
cord-283382-t890r7xp	27	32	be	be	VB
cord-283382-t890r7xp	27	33	vectorized	vectorize	VBN
cord-283382-t890r7xp	27	34	for	for	IN
cord-283382-t890r7xp	27	35	easy	easy	JJ
cord-283382-t890r7xp	27	36	manipulation	manipulation	NN
cord-283382-t890r7xp	27	37	(	(	-LRB-
cord-283382-t890r7xp	27	38	16	16	CD
cord-283382-t890r7xp	27	39	,	,	,
cord-283382-t890r7xp	27	40	(	(	-LRB-
cord-283382-t890r7xp	27	41	19	19	CD
cord-283382-t890r7xp	27	42	)	)	-RRB-
cord-283382-t890r7xp	27	43	(	(	-LRB-
cord-283382-t890r7xp	27	44	20	20	CD
cord-283382-t890r7xp	27	45	)	)	-RRB-
cord-283382-t890r7xp	27	46	(	(	-LRB-
cord-283382-t890r7xp	27	47	21	21	CD
cord-283382-t890r7xp	27	48	)	)	-RRB-
cord-283382-t890r7xp	27	49	.	.	.
cord-283382-t890r7xp	28	1	Further	further	JJ
cord-283382-t890r7xp	28	2	improvements	improvement	NNS
cord-283382-t890r7xp	28	3	to	to	IN
cord-283382-t890r7xp	28	4	these	these	DT
cord-283382-t890r7xp	28	5	first	first	JJ
cord-283382-t890r7xp	28	6	-	-	HYPH
cord-283382-t890r7xp	28	7	generation	generation	NN
cord-283382-t890r7xp	28	8	Ad	ad	NN
cord-283382-t890r7xp	28	9	vectors	vector	NNS
cord-283382-t890r7xp	28	10	have	have	VBP
cord-283382-t890r7xp	28	11	been	be	VBN
cord-283382-t890r7xp	28	12	developed	develop	VBN
cord-283382-t890r7xp	28	13	in	in	IN
cord-283382-t890r7xp	28	14	which	which	WDT
cord-283382-t890r7xp	28	15	the	the	DT
cord-283382-t890r7xp	28	16	E3	E3	NNP
cord-283382-t890r7xp	28	17	region	region	NN
cord-283382-t890r7xp	28	18	is	be	VBZ
cord-283382-t890r7xp	28	19	also	also	RB
cord-283382-t890r7xp	28	20	deleted	delete	VBN
cord-283382-t890r7xp	28	21	,	,	,
cord-283382-t890r7xp	28	22	to	to	TO
cord-283382-t890r7xp	28	23	accommodate	accommodate	VB
cord-283382-t890r7xp	28	24	a	a	DT
cord-283382-t890r7xp	28	25	larger	large	JJR
cord-283382-t890r7xp	28	26	heterologous	heterologous	JJ
cord-283382-t890r7xp	28	27	transgene	transgene	NN
cord-283382-t890r7xp	28	28	capacity	capacity	NN
cord-283382-t890r7xp	28	29	of	of	IN
cord-283382-t890r7xp	28	30	∼7.5	∼7.5	NNP
cord-283382-t890r7xp	28	31	kbp	kbp	NNP
cord-283382-t890r7xp	28	32	.	.	.
cord-283382-t890r7xp	29	1	Ad	ad	NN
cord-283382-t890r7xp	29	2	vectors	vector	NNS
cord-283382-t890r7xp	29	3	display	display	VBP
cord-283382-t890r7xp	29	4	a	a	DT
cord-283382-t890r7xp	29	5	number	number	NN
cord-283382-t890r7xp	29	6	of	of	IN
cord-283382-t890r7xp	29	7	desirable	desirable	JJ
cord-283382-t890r7xp	29	8	characteristics	characteristic	NNS
cord-283382-t890r7xp	29	9	which	which	WDT
cord-283382-t890r7xp	29	10	make	make	VBP
cord-283382-t890r7xp	29	11	them	-PRON-	PRP
cord-283382-t890r7xp	29	12	particularly	particularly	RB
cord-283382-t890r7xp	29	13	well	well	RB
cord-283382-t890r7xp	29	14	-	-	HYPH
cord-283382-t890r7xp	29	15	suited	suit	VBN
cord-283382-t890r7xp	29	16	to	to	IN
cord-283382-t890r7xp	29	17	prophylactic	prophylactic	JJ
cord-283382-t890r7xp	29	18	vaccine	vaccine	NN
cord-283382-t890r7xp	29	19	applications	application	NNS
cord-283382-t890r7xp	29	20	.	.	.
cord-283382-t890r7xp	30	1	Their	-PRON-	PRP$
cord-283382-t890r7xp	30	2	genome	genome	NN
cord-283382-t890r7xp	30	3	is	be	VBZ
cord-283382-t890r7xp	30	4	stable	stable	JJ
cord-283382-t890r7xp	30	5	and	and	CC
cord-283382-t890r7xp	30	6	easy	easy	JJ
cord-283382-t890r7xp	30	7	to	to	TO
cord-283382-t890r7xp	30	8	manipulate	manipulate	VB
cord-283382-t890r7xp	30	9	,	,	,
cord-283382-t890r7xp	30	10	they	-PRON-	PRP
cord-283382-t890r7xp	30	11	can	can	MD
cord-283382-t890r7xp	30	12	be	be	VB
cord-283382-t890r7xp	30	13	amplified	amplify	VBN
cord-283382-t890r7xp	30	14	and	and	CC
cord-283382-t890r7xp	30	15	produced	produce	VBN
cord-283382-t890r7xp	30	16	to	to	IN
cord-283382-t890r7xp	30	17	high	high	JJ
cord-283382-t890r7xp	30	18	titers	titer	NNS
cord-283382-t890r7xp	30	19	using	use	VBG
cord-283382-t890r7xp	30	20	various	various	JJ
cord-283382-t890r7xp	30	21	complementing	complement	VBG
cord-283382-t890r7xp	30	22	cell	cell	NN
cord-283382-t890r7xp	30	23	lines	line	NNS
cord-283382-t890r7xp	30	24	which	which	WDT
cord-283382-t890r7xp	30	25	adhere	adhere	VBP
cord-283382-t890r7xp	30	26	with	with	IN
cord-283382-t890r7xp	30	27	good	good	JJ
cord-283382-t890r7xp	30	28	clinical	clinical	JJ
cord-283382-t890r7xp	30	29	practice	practice	NN
cord-283382-t890r7xp	30	30	(	(	-LRB-
cord-283382-t890r7xp	30	31	GCP	GCP	NNP
cord-283382-t890r7xp	30	32	)	)	-RRB-
cord-283382-t890r7xp	30	33	procedures	procedure	NNS
cord-283382-t890r7xp	30	34	(	(	-LRB-
cord-283382-t890r7xp	30	35	22	22	CD
cord-283382-t890r7xp	30	36	)	)	-RRB-
cord-283382-t890r7xp	30	37	,	,	,
cord-283382-t890r7xp	30	38	and	and	CC
cord-283382-t890r7xp	30	39	they	-PRON-	PRP
cord-283382-t890r7xp	30	40	have	have	VBP
cord-283382-t890r7xp	30	41	an	an	DT
cord-283382-t890r7xp	30	42	outstanding	outstanding	JJ
cord-283382-t890r7xp	30	43	track	track	NN
cord-283382-t890r7xp	30	44	-	-	HYPH
cord-283382-t890r7xp	30	45	record	record	NN
cord-283382-t890r7xp	30	46	as	as	RB
cord-283382-t890r7xp	30	47	safe	safe	JJ
cord-283382-t890r7xp	30	48	and	and	CC
cord-283382-t890r7xp	30	49	immunogenic	immunogenic	JJ
cord-283382-t890r7xp	30	50	vaccines	vaccine	NNS
cord-283382-t890r7xp	30	51	in	in	IN
cord-283382-t890r7xp	30	52	numerous	numerous	JJ
cord-283382-t890r7xp	30	53	human	human	JJ
cord-283382-t890r7xp	30	54	clinical	clinical	JJ
cord-283382-t890r7xp	30	55	trials	trial	NNS
cord-283382-t890r7xp	30	56	(	(	-LRB-
cord-283382-t890r7xp	30	57	1	1	CD
cord-283382-t890r7xp	30	58	)	)	-RRB-
cord-283382-t890r7xp	30	59	(	(	-LRB-
cord-283382-t890r7xp	30	60	2	2	LS
cord-283382-t890r7xp	30	61	)	)	-RRB-
cord-283382-t890r7xp	30	62	(	(	-LRB-
cord-283382-t890r7xp	30	63	3	3	LS
cord-283382-t890r7xp	30	64	)	)	-RRB-
cord-283382-t890r7xp	30	65	(	(	-LRB-
cord-283382-t890r7xp	30	66	4	4	LS
cord-283382-t890r7xp	30	67	)	)	-RRB-
cord-283382-t890r7xp	30	68	(	(	-LRB-
cord-283382-t890r7xp	30	69	5	5	LS
cord-283382-t890r7xp	30	70	)	)	-RRB-
cord-283382-t890r7xp	30	71	(	(	-LRB-
cord-283382-t890r7xp	30	72	6	6	LS
cord-283382-t890r7xp	30	73	)	)	-RRB-
cord-283382-t890r7xp	30	74	(	(	-LRB-
cord-283382-t890r7xp	30	75	7	7	LS
cord-283382-t890r7xp	30	76	)	)	-RRB-
cord-283382-t890r7xp	30	77	(	(	-LRB-
cord-283382-t890r7xp	30	78	23	23	CD
cord-283382-t890r7xp	30	79	)	)	-RRB-
cord-283382-t890r7xp	30	80	(	(	-LRB-
cord-283382-t890r7xp	30	81	24	24	CD
cord-283382-t890r7xp	30	82	)	)	-RRB-
cord-283382-t890r7xp	30	83	(	(	-LRB-
cord-283382-t890r7xp	30	84	25	25	CD
cord-283382-t890r7xp	30	85	)	)	-RRB-
cord-283382-t890r7xp	30	86	.	.	.
cord-283382-t890r7xp	31	1	Historically	historically	RB
cord-283382-t890r7xp	31	2	,	,	,
cord-283382-t890r7xp	31	3	the	the	DT
cord-283382-t890r7xp	31	4	most	most	RBS
cord-283382-t890r7xp	31	5	commonly	commonly	RB
cord-283382-t890r7xp	31	6	used	use	VBN
cord-283382-t890r7xp	31	7	rAd	rAd	NNP
cord-283382-t890r7xp	31	8	has	have	VBZ
cord-283382-t890r7xp	31	9	been	be	VBN
cord-283382-t890r7xp	31	10	Human	Human	NNP
cord-283382-t890r7xp	31	11	mastadenovirus	mastadenovirus	NNP
cord-283382-t890r7xp	31	12	C	C	NNP
cord-283382-t890r7xp	31	13	,	,	,
cord-283382-t890r7xp	31	14	Human	Human	NNP
cord-283382-t890r7xp	31	15	Adenovirus	Adenovirus	NNP
cord-283382-t890r7xp	32	1	Type-5	type-5	NN
cord-283382-t890r7xp	33	1	(	(	-LRB-
cord-283382-t890r7xp	33	2	HAdV	HAdV	NNP
cord-283382-t890r7xp	33	3	-	-	HYPH
cord-283382-t890r7xp	33	4	C5	C5	NNP
cord-283382-t890r7xp	33	5	,	,	,
cord-283382-t890r7xp	33	6	referred	refer	VBD
cord-283382-t890r7xp	33	7	to	to	IN
cord-283382-t890r7xp	33	8	Ad5	ad5	CD
cord-283382-t890r7xp	33	9	throughout	throughout	IN
cord-283382-t890r7xp	33	10	this	this	DT
cord-283382-t890r7xp	33	11	manuscript	manuscript	NN
cord-283382-t890r7xp	33	12	)	)	-RRB-
cord-283382-t890r7xp	33	13	.	.	.
cord-283382-t890r7xp	34	1	However	however	RB
cord-283382-t890r7xp	34	2	,	,	,
cord-283382-t890r7xp	34	3	despite	despite	IN
cord-283382-t890r7xp	34	4	its	-PRON-	PRP$
cord-283382-t890r7xp	34	5	well	well	RB
cord-283382-t890r7xp	34	6	-	-	HYPH
cord-283382-t890r7xp	34	7	characterized	characterize	VBN
cord-283382-t890r7xp	34	8	biology	biology	NN
cord-283382-t890r7xp	34	9	and	and	CC
cord-283382-t890r7xp	34	10	robust	robust	JJ
cord-283382-t890r7xp	34	11	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	34	12	,	,	,
cord-283382-t890r7xp	34	13	high	high	JJ
cord-283382-t890r7xp	34	14	seroprevalence	seroprevalence	NN
cord-283382-t890r7xp	34	15	has	have	VBZ
cord-283382-t890r7xp	34	16	limited	limit	VBN
cord-283382-t890r7xp	34	17	its	-PRON-	PRP$
cord-283382-t890r7xp	34	18	widespread	widespread	JJ
cord-283382-t890r7xp	34	19	use	use	NN
cord-283382-t890r7xp	34	20	in	in	IN
cord-283382-t890r7xp	34	21	humans	human	NNS
cord-283382-t890r7xp	34	22	and	and	CC
cord-283382-t890r7xp	34	23	has	have	VBZ
cord-283382-t890r7xp	34	24	prompted	prompt	VBN
cord-283382-t890r7xp	34	25	the	the	DT
cord-283382-t890r7xp	34	26	development	development	NN
cord-283382-t890r7xp	34	27	and	and	CC
cord-283382-t890r7xp	34	28	investigation	investigation	NN
cord-283382-t890r7xp	34	29	of	of	IN
cord-283382-t890r7xp	34	30	novel	novel	NN
cord-283382-t890r7xp	34	31	Ad	ad	NN
cord-283382-t890r7xp	34	32	species	specie	NNS
cord-283382-t890r7xp	34	33	,	,	,
cord-283382-t890r7xp	34	34	either	either	CC
cord-283382-t890r7xp	34	35	rare	rare	JJ
cord-283382-t890r7xp	34	36	species	specie	NNS
cord-283382-t890r7xp	34	37	human	human	JJ
cord-283382-t890r7xp	34	38	Ads	ad	NNS
cord-283382-t890r7xp	34	39	(	(	-LRB-
cord-283382-t890r7xp	34	40	6	6	CD
cord-283382-t890r7xp	34	41	,	,	,
cord-283382-t890r7xp	34	42	20	20	CD
cord-283382-t890r7xp	34	43	,	,	,
cord-283382-t890r7xp	34	44	26	26	CD
cord-283382-t890r7xp	34	45	)	)	-RRB-
cord-283382-t890r7xp	34	46	or	or	CC
cord-283382-t890r7xp	34	47	those	those	DT
cord-283382-t890r7xp	34	48	derived	derive	VBN
cord-283382-t890r7xp	34	49	from	from	IN
cord-283382-t890r7xp	34	50	NHPs	nhp	NNS
cord-283382-t890r7xp	34	51	(	(	-LRB-
cord-283382-t890r7xp	34	52	5	5	CD
cord-283382-t890r7xp	34	53	,	,	,
cord-283382-t890r7xp	34	54	8	8	CD
cord-283382-t890r7xp	34	55	,	,	,
cord-283382-t890r7xp	34	56	27	27	CD
cord-283382-t890r7xp	34	57	)	)	-RRB-
cord-283382-t890r7xp	34	58	,	,	,
cord-283382-t890r7xp	34	59	many	many	JJ
cord-283382-t890r7xp	34	60	of	of	IN
cord-283382-t890r7xp	34	61	which	which	WDT
cord-283382-t890r7xp	34	62	have	have	VBP
cord-283382-t890r7xp	34	63	very	very	RB
cord-283382-t890r7xp	34	64	low	low	JJ
cord-283382-t890r7xp	34	65	seroprevalence	seroprevalence	NN
cord-283382-t890r7xp	34	66	(	(	-LRB-
cord-283382-t890r7xp	34	67	27	27	CD
cord-283382-t890r7xp	34	68	)	)	-RRB-
cord-283382-t890r7xp	34	69	(	(	-LRB-
cord-283382-t890r7xp	34	70	28	28	CD
cord-283382-t890r7xp	34	71	)	)	-RRB-
cord-283382-t890r7xp	34	72	(	(	-LRB-
cord-283382-t890r7xp	34	73	29	29	CD
cord-283382-t890r7xp	34	74	)	)	-RRB-
cord-283382-t890r7xp	34	75	(	(	-LRB-
cord-283382-t890r7xp	34	76	30	30	CD
cord-283382-t890r7xp	34	77	)	)	-RRB-
cord-283382-t890r7xp	34	78	(	(	-LRB-
cord-283382-t890r7xp	34	79	31	31	CD
cord-283382-t890r7xp	34	80	)	)	-RRB-
cord-283382-t890r7xp	34	81	.	.	.
cord-283382-t890r7xp	35	1	For	for	IN
cord-283382-t890r7xp	35	2	the	the	DT
cord-283382-t890r7xp	35	3	purpose	purpose	NN
cord-283382-t890r7xp	35	4	of	of	IN
cord-283382-t890r7xp	35	5	this	this	DT
cord-283382-t890r7xp	35	6	review	review	NN
cord-283382-t890r7xp	35	7	,	,	,
cord-283382-t890r7xp	35	8	the	the	DT
cord-283382-t890r7xp	35	9	nomenclature	nomenclature	NN
cord-283382-t890r7xp	35	10	of	of	IN
cord-283382-t890r7xp	35	11	Ad	ad	NN
cord-283382-t890r7xp	35	12	types	type	NNS
cord-283382-t890r7xp	35	13	will	will	MD
cord-283382-t890r7xp	35	14	use	use	VB
cord-283382-t890r7xp	35	15	reference	reference	NN
cord-283382-t890r7xp	35	16	to	to	IN
cord-283382-t890r7xp	35	17	the	the	DT
cord-283382-t890r7xp	35	18	vertebrate	vertebrate	JJ
cord-283382-t890r7xp	35	19	species	specie	NNS
cord-283382-t890r7xp	35	20	from	from	IN
cord-283382-t890r7xp	35	21	which	which	WDT
cord-283382-t890r7xp	35	22	the	the	DT
cord-283382-t890r7xp	35	23	vector	vector	NN
cord-283382-t890r7xp	35	24	was	be	VBD
cord-283382-t890r7xp	35	25	derived	derive	VBN
cord-283382-t890r7xp	35	26	(	(	-LRB-
cord-283382-t890r7xp	35	27	i.e.	i.e.	FW
cord-283382-t890r7xp	35	28	,	,	,
cord-283382-t890r7xp	35	29	H	h	NN
cord-283382-t890r7xp	35	30	for	for	IN
cord-283382-t890r7xp	35	31	human	human	NN
cord-283382-t890r7xp	35	32	or	or	CC
cord-283382-t890r7xp	35	33	Ch	Ch	NNP
cord-283382-t890r7xp	35	34	for	for	IN
cord-283382-t890r7xp	35	35	chimpanzee	chimpanzee	NN
cord-283382-t890r7xp	35	36	)	)	-RRB-
cord-283382-t890r7xp	35	37	followed	follow	VBN
cord-283382-t890r7xp	35	38	by	by	IN
cord-283382-t890r7xp	35	39	the	the	DT
cord-283382-t890r7xp	35	40	virus	virus	NN
cord-283382-t890r7xp	35	41	type	type	NN
cord-283382-t890r7xp	35	42	number	number	NN
cord-283382-t890r7xp	35	43	,	,	,
cord-283382-t890r7xp	35	44	as	as	IN
cord-283382-t890r7xp	35	45	outlined	outline	VBN
cord-283382-t890r7xp	35	46	in	in	IN
cord-283382-t890r7xp	35	47	Table	Table	NNP
cord-283382-t890r7xp	35	48	1	1	CD
cord-283382-t890r7xp	35	49	.	.	.
cord-283382-t890r7xp	36	1	Human	Human	NNP
cord-283382-t890r7xp	36	2	Ad	ad	NN
cord-283382-t890r7xp	36	3	vectors	vector	NNS
cord-283382-t890r7xp	36	4	will	will	MD
cord-283382-t890r7xp	36	5	include	include	VB
cord-283382-t890r7xp	36	6	their	-PRON-	PRP$
cord-283382-t890r7xp	36	7	assigned	assign	VBN
cord-283382-t890r7xp	36	8	adenovirus	adenovirus	NN
cord-283382-t890r7xp	36	9	species	species	NN
cord-283382-t890r7xp	36	10	group	group	NN
cord-283382-t890r7xp	36	11	(	(	-LRB-
cord-283382-t890r7xp	36	12	i.e.	i.e.	FW
cord-283382-t890r7xp	36	13	,	,	,
cord-283382-t890r7xp	36	14	A	A	NNP
cord-283382-t890r7xp	36	15	-	-	HYPH
cord-283382-t890r7xp	36	16	G	G	NNP
cord-283382-t890r7xp	36	17	)	)	-RRB-
cord-283382-t890r7xp	36	18	.	.	.
cord-283382-t890r7xp	37	1	This	this	DT
cord-283382-t890r7xp	37	2	nomenclature	nomenclature	NN
cord-283382-t890r7xp	37	3	has	have	VBZ
cord-283382-t890r7xp	37	4	been	be	VBN
cord-283382-t890r7xp	37	5	proposed	propose	VBN
cord-283382-t890r7xp	37	6	to	to	IN
cord-283382-t890r7xp	37	7	ICTV	ICTV	NNP
cord-283382-t890r7xp	37	8	by	by	IN
cord-283382-t890r7xp	37	9	Dr.	Dr.	NNP
cord-283382-t890r7xp	37	10	Don	Don	NNP
cord-283382-t890r7xp	37	11	Seto	Seto	NNP
cord-283382-t890r7xp	37	12	,	,	,
cord-283382-t890r7xp	37	13	George	George	NNP
cord-283382-t890r7xp	37	14	Mason	Mason	NNP
cord-283382-t890r7xp	37	15	University	University	NNP
cord-283382-t890r7xp	37	16	and	and	CC
cord-283382-t890r7xp	37	17	Dr.	Dr.	NNP
cord-283382-t890r7xp	37	18	James	James	NNP
cord-283382-t890r7xp	37	19	Chodosh	Chodosh	NNP
cord-283382-t890r7xp	37	20	,	,	,
cord-283382-t890r7xp	37	21	Harvard	Harvard	NNP
cord-283382-t890r7xp	37	22	University	University	NNP
cord-283382-t890r7xp	37	23	(	(	-LRB-
cord-283382-t890r7xp	37	24	personal	personal	JJ
cord-283382-t890r7xp	37	25	communication	communication	NN
cord-283382-t890r7xp	37	26	)	)	-RRB-
cord-283382-t890r7xp	37	27	.	.	.
cord-283382-t890r7xp	38	1	The	the	DT
cord-283382-t890r7xp	38	2	use	use	NN
cord-283382-t890r7xp	38	3	of	of	IN
cord-283382-t890r7xp	38	4	non	non	JJ
cord-283382-t890r7xp	38	5	-	-	JJ
cord-283382-t890r7xp	38	6	replicating	replicate	VBG
cord-283382-t890r7xp	38	7	viral	viral	JJ
cord-283382-t890r7xp	38	8	vectors	vector	NNS
cord-283382-t890r7xp	38	9	as	as	IN
cord-283382-t890r7xp	38	10	a	a	DT
cord-283382-t890r7xp	38	11	vaccine	vaccine	NN
cord-283382-t890r7xp	38	12	platform	platform	NN
cord-283382-t890r7xp	38	13	has	have	VBZ
cord-283382-t890r7xp	38	14	several	several	JJ
cord-283382-t890r7xp	38	15	advantages	advantage	NNS
cord-283382-t890r7xp	38	16	over	over	IN
cord-283382-t890r7xp	38	17	other	other	JJ
cord-283382-t890r7xp	38	18	vaccine	vaccine	NN
cord-283382-t890r7xp	38	19	formulations	formulation	NNS
cord-283382-t890r7xp	38	20	(	(	-LRB-
cord-283382-t890r7xp	38	21	i.e.	i.e.	FW
cord-283382-t890r7xp	38	22	,	,	,
cord-283382-t890r7xp	38	23	recombinant	recombinant	JJ
cord-283382-t890r7xp	38	24	protein	protein	NN
cord-283382-t890r7xp	38	25	,	,	,
cord-283382-t890r7xp	38	26	inactivated	inactivate	VBN
cord-283382-t890r7xp	38	27	particles	particle	NNS
cord-283382-t890r7xp	38	28	)	)	-RRB-
cord-283382-t890r7xp	38	29	.	.	.
cord-283382-t890r7xp	39	1	Viral	viral	JJ
cord-283382-t890r7xp	39	2	vectored	vectore	VBN
cord-283382-t890r7xp	39	3	vaccines	vaccine	NNS
cord-283382-t890r7xp	39	4	retain	retain	VBP
cord-283382-t890r7xp	39	5	some	some	DT
cord-283382-t890r7xp	39	6	characteristics	characteristic	NNS
cord-283382-t890r7xp	39	7	of	of	IN
cord-283382-t890r7xp	39	8	a	a	DT
cord-283382-t890r7xp	39	9	live	live	JJ
cord-283382-t890r7xp	39	10	attenuated	attenuated	JJ
cord-283382-t890r7xp	39	11	vaccine	vaccine	NN
cord-283382-t890r7xp	39	12	in	in	IN
cord-283382-t890r7xp	39	13	terms	term	NNS
cord-283382-t890r7xp	39	14	of	of	IN
cord-283382-t890r7xp	39	15	their	-PRON-	PRP$
cord-283382-t890r7xp	39	16	ability	ability	NN
cord-283382-t890r7xp	39	17	to	to	TO
cord-283382-t890r7xp	39	18	enter	enter	VB
cord-283382-t890r7xp	39	19	target	target	NN
cord-283382-t890r7xp	39	20	cells	cell	NNS
cord-283382-t890r7xp	39	21	,	,	,
cord-283382-t890r7xp	39	22	engage	engage	VB
cord-283382-t890r7xp	39	23	intracellular	intracellular	JJ
cord-283382-t890r7xp	39	24	trafficking	traffic	VBG
cord-283382-t890r7xp	39	25	pathways	pathway	NNS
cord-283382-t890r7xp	39	26	to	to	TO
cord-283382-t890r7xp	39	27	deliver	deliver	VB
cord-283382-t890r7xp	39	28	their	-PRON-	PRP$
cord-283382-t890r7xp	39	29	genome	genome	NN
cord-283382-t890r7xp	39	30	and	and	CC
cord-283382-t890r7xp	39	31	facilitate	facilitate	VB
cord-283382-t890r7xp	39	32	antigen	antigen	NN
cord-283382-t890r7xp	39	33	(	(	-LRB-
cord-283382-t890r7xp	39	34	Ag	Ag	NNP
cord-283382-t890r7xp	39	35	)	)	-RRB-
cord-283382-t890r7xp	39	36	expression	expression	NN
cord-283382-t890r7xp	39	37	and	and	CC
cord-283382-t890r7xp	39	38	subsequent	subsequent	JJ
cord-283382-t890r7xp	39	39	Ag	Ag	NNP
cord-283382-t890r7xp	39	40	-	-	HYPH
cord-283382-t890r7xp	39	41	presentation	presentation	NN
cord-283382-t890r7xp	39	42	in	in	IN
cord-283382-t890r7xp	39	43	vivo	vivo	NN
cord-283382-t890r7xp	39	44	,	,	,
cord-283382-t890r7xp	39	45	but	but	CC
cord-283382-t890r7xp	39	46	(	(	-LRB-
cord-283382-t890r7xp	39	47	17	17	CD
cord-283382-t890r7xp	39	48	)	)	-RRB-
cord-283382-t890r7xp	39	49	and	and	CC
cord-283382-t890r7xp	39	50	was	be	VBD
cord-283382-t890r7xp	39	51	created	create	VBN
cord-283382-t890r7xp	39	52	with	with	IN
cord-283382-t890r7xp	39	53	©	©	NNP
cord-283382-t890r7xp	39	54	BioRender	BioRender	NNP
cord-283382-t890r7xp	39	55	-biorender.com	-biorender.com	ADD
cord-283382-t890r7xp	39	56	.	.	.
cord-283382-t890r7xp	40	1	Proteins	protein	NNS
cord-283382-t890r7xp	40	2	are	be	VBP
cord-283382-t890r7xp	40	3	not	not	RB
cord-283382-t890r7xp	40	4	to	to	TO
cord-283382-t890r7xp	40	5	scale	scale	VB
cord-283382-t890r7xp	40	6	.	.	.
cord-283382-t890r7xp	41	1	possess	possess	VB
cord-283382-t890r7xp	41	2	additional	additional	JJ
cord-283382-t890r7xp	41	3	safety	safety	NN
cord-283382-t890r7xp	41	4	features	feature	NNS
cord-283382-t890r7xp	41	5	.	.	.
cord-283382-t890r7xp	42	1	Furthermore	furthermore	RB
cord-283382-t890r7xp	42	2	,	,	,
cord-283382-t890r7xp	42	3	in	in	IN
cord-283382-t890r7xp	42	4	order	order	NN
cord-283382-t890r7xp	42	5	to	to	TO
cord-283382-t890r7xp	42	6	drive	drive	VB
cord-283382-t890r7xp	42	7	the	the	DT
cord-283382-t890r7xp	42	8	expression	expression	NN
cord-283382-t890r7xp	42	9	of	of	IN
cord-283382-t890r7xp	42	10	substantial	substantial	JJ
cord-283382-t890r7xp	42	11	quantities	quantity	NNS
cord-283382-t890r7xp	42	12	of	of	IN
cord-283382-t890r7xp	42	13	transcripts	transcript	NNS
cord-283382-t890r7xp	42	14	which	which	WDT
cord-283382-t890r7xp	42	15	correspond	correspond	VBP
cord-283382-t890r7xp	42	16	to	to	IN
cord-283382-t890r7xp	42	17	the	the	DT
cord-283382-t890r7xp	42	18	encoded	encoded	JJ
cord-283382-t890r7xp	42	19	vaccine	vaccine	NN
cord-283382-t890r7xp	42	20	Ag	Ag	NNP
cord-283382-t890r7xp	42	21	,	,	,
cord-283382-t890r7xp	42	22	non	non	JJ
cord-283382-t890r7xp	42	23	-	-	JJ
cord-283382-t890r7xp	42	24	replicating	replicate	VBG
cord-283382-t890r7xp	42	25	Ad	ad	NN
cord-283382-t890r7xp	42	26	vectors	vector	NNS
cord-283382-t890r7xp	42	27	make	make	VBP
cord-283382-t890r7xp	42	28	use	use	NN
cord-283382-t890r7xp	42	29	of	of	IN
cord-283382-t890r7xp	42	30	powerful	powerful	JJ
cord-283382-t890r7xp	42	31	exogenous	exogenous	JJ
cord-283382-t890r7xp	42	32	promoters	promoter	NNS
cord-283382-t890r7xp	42	33	,	,	,
cord-283382-t890r7xp	42	34	such	such	JJ
cord-283382-t890r7xp	42	35	as	as	IN
cord-283382-t890r7xp	42	36	the	the	DT
cord-283382-t890r7xp	42	37	cytomegalovirus	cytomegalovirus	NN
cord-283382-t890r7xp	42	38	(	(	-LRB-
cord-283382-t890r7xp	42	39	CMV	CMV	NNP
cord-283382-t890r7xp	42	40	)	)	-RRB-
cord-283382-t890r7xp	42	41	promoter	promoter	NN
cord-283382-t890r7xp	42	42	(	(	-LRB-
cord-283382-t890r7xp	42	43	32	32	CD
cord-283382-t890r7xp	42	44	)	)	-RRB-
cord-283382-t890r7xp	42	45	.	.	.
cord-283382-t890r7xp	43	1	Unlike	unlike	IN
cord-283382-t890r7xp	43	2	recombinant	recombinant	JJ
cord-283382-t890r7xp	43	3	protein	protein	NN
cord-283382-t890r7xp	43	4	or	or	CC
cord-283382-t890r7xp	43	5	inactivated	inactivate	VBN
cord-283382-t890r7xp	43	6	vaccines	vaccine	NNS
cord-283382-t890r7xp	43	7	in	in	IN
cord-283382-t890r7xp	43	8	which	which	WDT
cord-283382-t890r7xp	43	9	antigen	antigen	NN
cord-283382-t890r7xp	43	10	quantity	quantity	NN
cord-283382-t890r7xp	43	11	is	be	VBZ
cord-283382-t890r7xp	43	12	limited	limit	VBN
cord-283382-t890r7xp	43	13	to	to	IN
cord-283382-t890r7xp	43	14	the	the	DT
cord-283382-t890r7xp	43	15	input	input	NN
cord-283382-t890r7xp	43	16	vaccine	vaccine	NN
cord-283382-t890r7xp	43	17	dose	dose	NN
cord-283382-t890r7xp	43	18	,	,	,
cord-283382-t890r7xp	43	19	the	the	DT
cord-283382-t890r7xp	43	20	use	use	NN
cord-283382-t890r7xp	43	21	of	of	IN
cord-283382-t890r7xp	43	22	exogenous	exogenous	JJ
cord-283382-t890r7xp	43	23	promoters	promoter	NNS
cord-283382-t890r7xp	43	24	facilitates	facilitate	VBZ
cord-283382-t890r7xp	43	25	more	more	RBR
cord-283382-t890r7xp	43	26	sustained	sustained	JJ
cord-283382-t890r7xp	43	27	transgene	transgene	NN
cord-283382-t890r7xp	43	28	antigen	antigen	NN
cord-283382-t890r7xp	43	29	expression	expression	NN
cord-283382-t890r7xp	43	30	in	in	IN
cord-283382-t890r7xp	43	31	vivo	vivo	NN
cord-283382-t890r7xp	43	32	.	.	.
cord-283382-t890r7xp	44	1	In	in	IN
cord-283382-t890r7xp	44	2	general	general	JJ
cord-283382-t890r7xp	44	3	,	,	,
cord-283382-t890r7xp	44	4	Ad	ad	NN
cord-283382-t890r7xp	44	5	vectors	vector	NNS
cord-283382-t890r7xp	44	6	are	be	VBP
cord-283382-t890r7xp	44	7	well	well	RB
cord-283382-t890r7xp	44	8	-	-	HYPH
cord-283382-t890r7xp	44	9	established	establish	VBN
cord-283382-t890r7xp	44	10	to	to	TO
cord-283382-t890r7xp	44	11	stimulate	stimulate	VB
cord-283382-t890r7xp	44	12	CD8	CD8	NNP
cord-283382-t890r7xp	44	13	+	+	CC
cord-283382-t890r7xp	44	14	T	T	NNP
cord-283382-t890r7xp	44	15	cell	cell	NN
cord-283382-t890r7xp	44	16	responses	response	NNS
cord-283382-t890r7xp	44	17	directed	direct	VBN
cord-283382-t890r7xp	44	18	toward	toward	IN
cord-283382-t890r7xp	44	19	transgene	transgene	NN
cord-283382-t890r7xp	44	20	Ag	Ag	NNP
cord-283382-t890r7xp	44	21	,	,	,
cord-283382-t890r7xp	44	22	with	with	IN
cord-283382-t890r7xp	44	23	selected	select	VBN
cord-283382-t890r7xp	44	24	Ad	ad	NN
cord-283382-t890r7xp	44	25	types	type	NNS
cord-283382-t890r7xp	44	26	confirmed	confirm	VBD
cord-283382-t890r7xp	44	27	to	to	TO
cord-283382-t890r7xp	44	28	elicit	elicit	VB
cord-283382-t890r7xp	44	29	robust	robust	JJ
cord-283382-t890r7xp	44	30	cellular	cellular	JJ
cord-283382-t890r7xp	44	31	immunity	immunity	NN
cord-283382-t890r7xp	44	32	in	in	IN
cord-283382-t890r7xp	44	33	both	both	DT
cord-283382-t890r7xp	44	34	animal	animal	NN
cord-283382-t890r7xp	44	35	models	model	NNS
cord-283382-t890r7xp	44	36	(	(	-LRB-
cord-283382-t890r7xp	44	37	8	8	CD
cord-283382-t890r7xp	44	38	,	,	,
cord-283382-t890r7xp	44	39	(	(	-LRB-
cord-283382-t890r7xp	44	40	32	32	CD
cord-283382-t890r7xp	44	41	)	)	-RRB-
cord-283382-t890r7xp	44	42	(	(	-LRB-
cord-283382-t890r7xp	44	43	33	33	CD
cord-283382-t890r7xp	44	44	)	)	-RRB-
cord-283382-t890r7xp	44	45	(	(	-LRB-
cord-283382-t890r7xp	44	46	34	34	CD
cord-283382-t890r7xp	44	47	)	)	-RRB-
cord-283382-t890r7xp	44	48	(	(	-LRB-
cord-283382-t890r7xp	44	49	35	35	CD
cord-283382-t890r7xp	44	50	)	)	-RRB-
cord-283382-t890r7xp	44	51	(	(	-LRB-
cord-283382-t890r7xp	44	52	36	36	CD
cord-283382-t890r7xp	44	53	)	)	-RRB-
cord-283382-t890r7xp	44	54	and	and	CC
cord-283382-t890r7xp	44	55	humans	human	NNS
cord-283382-t890r7xp	44	56	[	[	-LRB-
cord-283382-t890r7xp	44	57	(	(	-LRB-
cord-283382-t890r7xp	44	58	1	1	CD
cord-283382-t890r7xp	44	59	,	,	,
cord-283382-t890r7xp	44	60	3	3	CD
cord-283382-t890r7xp	44	61	,	,	,
cord-283382-t890r7xp	44	62	6	6	CD
cord-283382-t890r7xp	44	63	,	,	,
cord-283382-t890r7xp	44	64	23	23	CD
cord-283382-t890r7xp	44	65	,	,	,
cord-283382-t890r7xp	44	66	33	33	CD
cord-283382-t890r7xp	44	67	,	,	,
cord-283382-t890r7xp	44	68	37	37	CD
cord-283382-t890r7xp	44	69	)	)	-RRB-
cord-283382-t890r7xp	44	70	;	;	:
cord-283382-t890r7xp	44	71	see	see	VB
cord-283382-t890r7xp	44	72	Table	table	NN
cord-283382-t890r7xp	44	73	2	2	CD
cord-283382-t890r7xp	44	74	]	]	-RRB-
cord-283382-t890r7xp	44	75	.	.	.
cord-283382-t890r7xp	45	1	Memory	memory	NN
cord-283382-t890r7xp	45	2	CD8	CD8	NNP
cord-283382-t890r7xp	45	3	+	+	CC
cord-283382-t890r7xp	45	4	T	T	NNP
cord-283382-t890r7xp	45	5	cell	cell	NN
cord-283382-t890r7xp	45	6	responses	response	NNS
cord-283382-t890r7xp	45	7	elicited	elicit	VBD
cord-283382-t890r7xp	45	8	following	follow	VBG
cord-283382-t890r7xp	45	9	vaccination	vaccination	NN
cord-283382-t890r7xp	45	10	with	with	IN
cord-283382-t890r7xp	45	11	Ad	ad	NN
cord-283382-t890r7xp	45	12	vectors	vector	NNS
cord-283382-t890r7xp	45	13	exhibit	exhibit	VBP
cord-283382-t890r7xp	45	14	an	an	DT
cord-283382-t890r7xp	45	15	extended	extended	JJ
cord-283382-t890r7xp	45	16	contraction	contraction	NN
cord-283382-t890r7xp	45	17	phase	phase	NN
cord-283382-t890r7xp	45	18	(	(	-LRB-
cord-283382-t890r7xp	45	19	38	38	CD
cord-283382-t890r7xp	45	20	)	)	-RRB-
cord-283382-t890r7xp	45	21	.	.	.
cord-283382-t890r7xp	46	1	Importantly	importantly	RB
cord-283382-t890r7xp	46	2	,	,	,
cord-283382-t890r7xp	46	3	the	the	DT
cord-283382-t890r7xp	46	4	persistent	persistent	JJ
cord-283382-t890r7xp	46	5	Ag	Ag	NNP
cord-283382-t890r7xp	46	6	expression	expression	NN
cord-283382-t890r7xp	46	7	following	follow	VBG
cord-283382-t890r7xp	46	8	immunization	immunization	NN
cord-283382-t890r7xp	46	9	with	with	IN
cord-283382-t890r7xp	46	10	Ad	ad	NN
cord-283382-t890r7xp	46	11	vaccines	vaccine	NNS
cord-283382-t890r7xp	46	12	enables	enable	VBZ
cord-283382-t890r7xp	46	13	the	the	DT
cord-283382-t890r7xp	46	14	induction	induction	NN
cord-283382-t890r7xp	46	15	of	of	IN
cord-283382-t890r7xp	46	16	sustained	sustained	JJ
cord-283382-t890r7xp	46	17	immune	immune	JJ
cord-283382-t890r7xp	46	18	responses	response	NNS
cord-283382-t890r7xp	46	19	(	(	-LRB-
cord-283382-t890r7xp	46	20	5	5	CD
cord-283382-t890r7xp	46	21	,	,	,
cord-283382-t890r7xp	46	22	36	36	CD
cord-283382-t890r7xp	46	23	,	,	,
cord-283382-t890r7xp	46	24	(	(	-LRB-
cord-283382-t890r7xp	46	25	39	39	CD
cord-283382-t890r7xp	46	26	)	)	-RRB-
cord-283382-t890r7xp	46	27	(	(	-LRB-
cord-283382-t890r7xp	46	28	40	40	CD
cord-283382-t890r7xp	46	29	)	)	-RRB-
cord-283382-t890r7xp	46	30	(	(	-LRB-
cord-283382-t890r7xp	46	31	41	41	CD
cord-283382-t890r7xp	46	32	)	)	-RRB-
cord-283382-t890r7xp	46	33	,	,	,
cord-283382-t890r7xp	46	34	making	make	VBG
cord-283382-t890r7xp	46	35	them	-PRON-	PRP
cord-283382-t890r7xp	46	36	very	very	RB
cord-283382-t890r7xp	46	37	attractive	attractive	JJ
cord-283382-t890r7xp	46	38	vaccine	vaccine	NN
cord-283382-t890r7xp	46	39	vectors	vector	NNS
cord-283382-t890r7xp	46	40	for	for	IN
cord-283382-t890r7xp	46	41	conferring	confer	VBG
cord-283382-t890r7xp	46	42	long	long	RB
cord-283382-t890r7xp	46	43	-	-	HYPH
cord-283382-t890r7xp	46	44	lasting	last	VBG
cord-283382-t890r7xp	46	45	immunity	immunity	NN
cord-283382-t890r7xp	46	46	.	.	.
cord-283382-t890r7xp	47	1	It	-PRON-	PRP
cord-283382-t890r7xp	47	2	is	be	VBZ
cord-283382-t890r7xp	47	3	believed	believe	VBN
cord-283382-t890r7xp	47	4	that	that	IN
cord-283382-t890r7xp	47	5	the	the	DT
cord-283382-t890r7xp	47	6	prolonged	prolonged	JJ
cord-283382-t890r7xp	47	7	expression	expression	NN
cord-283382-t890r7xp	47	8	of	of	IN
cord-283382-t890r7xp	47	9	vaccine	vaccine	NN
cord-283382-t890r7xp	47	10	Ag	Ag	NNP
cord-283382-t890r7xp	47	11	facilitates	facilitate	VBZ
cord-283382-t890r7xp	47	12	the	the	DT
cord-283382-t890r7xp	47	13	maintenance	maintenance	NN
cord-283382-t890r7xp	47	14	of	of	IN
cord-283382-t890r7xp	47	15	effector	effector	NN
cord-283382-t890r7xp	47	16	CD8	CD8	NNP
cord-283382-t890r7xp	47	17	+	+	CC
cord-283382-t890r7xp	47	18	T	t	NN
cord-283382-t890r7xp	47	19	cells	cell	NNS
cord-283382-t890r7xp	47	20	while	while	IN
cord-283382-t890r7xp	47	21	simultaneously	simultaneously	RB
cord-283382-t890r7xp	47	22	permitting	permit	VBG
cord-283382-t890r7xp	47	23	their	-PRON-	PRP$
cord-283382-t890r7xp	47	24	differentiation	differentiation	NN
cord-283382-t890r7xp	47	25	into	into	IN
cord-283382-t890r7xp	47	26	central	central	JJ
cord-283382-t890r7xp	47	27	memory	memory	NN
cord-283382-t890r7xp	47	28	populations	population	NNS
cord-283382-t890r7xp	47	29	(	(	-LRB-
cord-283382-t890r7xp	47	30	36	36	CD
cord-283382-t890r7xp	47	31	)	)	-RRB-
cord-283382-t890r7xp	47	32	.	.	.
cord-283382-t890r7xp	48	1	Improved	improve	VBN
cord-283382-t890r7xp	48	2	understanding	understanding	NN
cord-283382-t890r7xp	48	3	into	into	IN
cord-283382-t890r7xp	48	4	how	how	WRB
cord-283382-t890r7xp	48	5	Ad	ad	NN
cord-283382-t890r7xp	48	6	vectors	vector	NNS
cord-283382-t890r7xp	48	7	prime	prime	JJ
cord-283382-t890r7xp	48	8	and	and	CC
cord-283382-t890r7xp	48	9	maintain	maintain	VB
cord-283382-t890r7xp	48	10	such	such	JJ
cord-283382-t890r7xp	48	11	long	long	RB
cord-283382-t890r7xp	48	12	-	-	HYPH
cord-283382-t890r7xp	48	13	lived	live	VBN
cord-283382-t890r7xp	48	14	responses	response	NNS
cord-283382-t890r7xp	48	15	will	will	MD
cord-283382-t890r7xp	48	16	be	be	VB
cord-283382-t890r7xp	48	17	crucial	crucial	JJ
cord-283382-t890r7xp	48	18	not	not	RB
cord-283382-t890r7xp	48	19	only	only	RB
cord-283382-t890r7xp	48	20	in	in	IN
cord-283382-t890r7xp	48	21	designing	design	VBG
cord-283382-t890r7xp	48	22	improved	improve	VBN
cord-283382-t890r7xp	48	23	Ad	ad	NN
cord-283382-t890r7xp	48	24	vaccines	vaccine	NNS
cord-283382-t890r7xp	48	25	,	,	,
cord-283382-t890r7xp	48	26	but	but	CC
cord-283382-t890r7xp	48	27	also	also	RB
cord-283382-t890r7xp	49	1	other	other	JJ
cord-283382-t890r7xp	49	2	vaccine	vaccine	NN
cord-283382-t890r7xp	49	3	Adenovirus	Adenovirus	NNP
cord-283382-t890r7xp	49	4	classification	classification	NN
cord-283382-t890r7xp	49	5	for	for	IN
cord-283382-t890r7xp	49	6	human	human	JJ
cord-283382-t890r7xp	49	7	and	and	CC
cord-283382-t890r7xp	49	8	non	non	JJ
cord-283382-t890r7xp	49	9	-	-	JJ
cord-283382-t890r7xp	49	10	human	human	JJ
cord-283382-t890r7xp	49	11	Ad	ad	NN
cord-283382-t890r7xp	49	12	vectors	vector	NNS
cord-283382-t890r7xp	49	13	referred	refer	VBN
cord-283382-t890r7xp	49	14	to	to	IN
cord-283382-t890r7xp	49	15	in	in	IN
cord-283382-t890r7xp	49	16	this	this	DT
cord-283382-t890r7xp	49	17	review	review	NN
cord-283382-t890r7xp	49	18	.	.	.
cord-283382-t890r7xp	50	1	The	the	DT
cord-283382-t890r7xp	50	2	nomenclature	nomenclature	NN
cord-283382-t890r7xp	50	3	of	of	IN
cord-283382-t890r7xp	50	4	Ad	ad	NN
cord-283382-t890r7xp	50	5	vectors	vector	NNS
cord-283382-t890r7xp	50	6	derived	derive	VBN
cord-283382-t890r7xp	50	7	from	from	IN
cord-283382-t890r7xp	50	8	non	non	JJ
cord-283382-t890r7xp	50	9	-	-	JJ
cord-283382-t890r7xp	50	10	human	human	JJ
cord-283382-t890r7xp	50	11	primates	primate	NNS
cord-283382-t890r7xp	50	12	,	,	,
cord-283382-t890r7xp	50	13	including	include	VBG
cord-283382-t890r7xp	50	14	chimpanzees	chimpanzee	NNS
cord-283382-t890r7xp	50	15	,	,	,
cord-283382-t890r7xp	50	16	is	be	VBZ
cord-283382-t890r7xp	50	17	not	not	RB
cord-283382-t890r7xp	50	18	standardized	standardize	VBN
cord-283382-t890r7xp	50	19	,	,	,
cord-283382-t890r7xp	50	20	resulting	result	VBG
cord-283382-t890r7xp	50	21	in	in	IN
cord-283382-t890r7xp	50	22	the	the	DT
cord-283382-t890r7xp	50	23	confusing	confusing	JJ
cord-283382-t890r7xp	50	24	use	use	NN
cord-283382-t890r7xp	50	25	of	of	IN
cord-283382-t890r7xp	50	26	multiple	multiple	JJ
cord-283382-t890r7xp	50	27	names	name	NNS
cord-283382-t890r7xp	50	28	assigned	assign	VBN
cord-283382-t890r7xp	50	29	by	by	IN
cord-283382-t890r7xp	50	30	individuals	individual	NNS
cord-283382-t890r7xp	50	31	who	who	WP
cord-283382-t890r7xp	50	32	vectorized	vectorize	VBD
cord-283382-t890r7xp	50	33	these	these	DT
cord-283382-t890r7xp	50	34	constructs	construct	NNS
cord-283382-t890r7xp	50	35	.	.	.
cord-283382-t890r7xp	51	1	In	in	IN
cord-283382-t890r7xp	51	2	this	this	DT
cord-283382-t890r7xp	51	3	review	review	NN
cord-283382-t890r7xp	51	4	text	text	NN
cord-283382-t890r7xp	51	5	,	,	,
cord-283382-t890r7xp	51	6	we	-PRON-	PRP
cord-283382-t890r7xp	51	7	propose	propose	VBP
cord-283382-t890r7xp	51	8	to	to	TO
cord-283382-t890r7xp	51	9	follow	follow	VB
cord-283382-t890r7xp	51	10	current	current	JJ
cord-283382-t890r7xp	51	11	standards	standard	NNS
cord-283382-t890r7xp	51	12	for	for	IN
cord-283382-t890r7xp	51	13	human	human	JJ
cord-283382-t890r7xp	51	14	Ad	ad	NN
cord-283382-t890r7xp	51	15	vectors	vector	NNS
cord-283382-t890r7xp	51	16	,	,	,
cord-283382-t890r7xp	51	17	such	such	JJ
cord-283382-t890r7xp	51	18	as	as	IN
cord-283382-t890r7xp	51	19	HAdV	HAdV	NNP
cord-283382-t890r7xp	51	20	-	-	HYPH
cord-283382-t890r7xp	51	21	C5	C5	NNP
cord-283382-t890r7xp	51	22	,	,	,
cord-283382-t890r7xp	51	23	as	as	IN
cord-283382-t890r7xp	51	24	outlined	outline	VBN
cord-283382-t890r7xp	51	25	by	by	IN
cord-283382-t890r7xp	51	26	ICTV	ICTV	NNP
cord-283382-t890r7xp	51	27	,	,	,
cord-283382-t890r7xp	51	28	for	for	IN
cord-283382-t890r7xp	51	29	descriptions	description	NNS
cord-283382-t890r7xp	51	30	of	of	IN
cord-283382-t890r7xp	51	31	Ad	ad	NN
cord-283382-t890r7xp	51	32	vectors	vector	NNS
cord-283382-t890r7xp	51	33	derived	derive	VBN
cord-283382-t890r7xp	51	34	from	from	IN
cord-283382-t890r7xp	51	35	chimpanzees	chimpanzee	NNS
cord-283382-t890r7xp	51	36	or	or	CC
cord-283382-t890r7xp	51	37	non	non	JJ
cord-283382-t890r7xp	51	38	-	-	JJ
cord-283382-t890r7xp	51	39	human	human	JJ
cord-283382-t890r7xp	51	40	primates	primate	NNS
cord-283382-t890r7xp	51	41	.	.	.
cord-283382-t890r7xp	52	1	Abbreviated	abbreviated	JJ
cord-283382-t890r7xp	52	2	"	"	``
cord-283382-t890r7xp	52	3	alternative	alternative	NN
cord-283382-t890r7xp	52	4	"	"	''
cord-283382-t890r7xp	52	5	names	name	NNS
cord-283382-t890r7xp	52	6	are	be	VBP
cord-283382-t890r7xp	52	7	used	use	VBN
cord-283382-t890r7xp	52	8	in	in	IN
cord-283382-t890r7xp	52	9	Table	table	NN
cord-283382-t890r7xp	52	10	2	2	CD
cord-283382-t890r7xp	52	11	platforms	platform	NNS
cord-283382-t890r7xp	52	12	which	which	WDT
cord-283382-t890r7xp	52	13	are	be	VBP
cord-283382-t890r7xp	52	14	optimized	optimize	VBN
cord-283382-t890r7xp	52	15	for	for	IN
cord-283382-t890r7xp	52	16	diverse	diverse	JJ
cord-283382-t890r7xp	52	17	disease	disease	NN
cord-283382-t890r7xp	52	18	targets	target	NNS
cord-283382-t890r7xp	52	19	.	.	.
cord-283382-t890r7xp	53	1	However	however	RB
cord-283382-t890r7xp	53	2	,	,	,
cord-283382-t890r7xp	53	3	the	the	DT
cord-283382-t890r7xp	53	4	precise	precise	JJ
cord-283382-t890r7xp	53	5	factors	factor	NNS
cord-283382-t890r7xp	53	6	which	which	WDT
cord-283382-t890r7xp	53	7	contribute	contribute	VBP
cord-283382-t890r7xp	53	8	to	to	IN
cord-283382-t890r7xp	53	9	the	the	DT
cord-283382-t890r7xp	53	10	robust	robust	JJ
cord-283382-t890r7xp	53	11	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	53	12	associated	associate	VBN
cord-283382-t890r7xp	53	13	with	with	IN
cord-283382-t890r7xp	53	14	particular	particular	JJ
cord-283382-t890r7xp	53	15	Ad	ad	NN
cord-283382-t890r7xp	53	16	-	-	HYPH
cord-283382-t890r7xp	53	17	vectored	vectore	VBN
cord-283382-t890r7xp	53	18	vaccines	vaccine	NNS
cord-283382-t890r7xp	53	19	are	be	VBP
cord-283382-t890r7xp	53	20	currently	currently	RB
cord-283382-t890r7xp	53	21	unclear	unclear	JJ
cord-283382-t890r7xp	53	22	.	.	.
cord-283382-t890r7xp	54	1	It	-PRON-	PRP
cord-283382-t890r7xp	54	2	is	be	VBZ
cord-283382-t890r7xp	54	3	widely	widely	RB
cord-283382-t890r7xp	54	4	appreciated	appreciate	VBN
cord-283382-t890r7xp	54	5	in	in	IN
cord-283382-t890r7xp	54	6	the	the	DT
cord-283382-t890r7xp	54	7	Ad	ad	NN
cord-283382-t890r7xp	54	8	vaccine	vaccine	NN
cord-283382-t890r7xp	54	9	field	field	NN
cord-283382-t890r7xp	54	10	that	that	WDT
cord-283382-t890r7xp	54	11	Ad	ad	NN
cord-283382-t890r7xp	54	12	vectors	vector	NNS
cord-283382-t890r7xp	54	13	can	can	MD
cord-283382-t890r7xp	54	14	act	act	VB
cord-283382-t890r7xp	54	15	as	as	IN
cord-283382-t890r7xp	54	16	a	a	DT
cord-283382-t890r7xp	54	17	"	"	``
cord-283382-t890r7xp	54	18	self	self	NN
cord-283382-t890r7xp	54	19	-	-	HYPH
cord-283382-t890r7xp	54	20	adjuvant	adjuvant	JJ
cord-283382-t890r7xp	54	21	,	,	,
cord-283382-t890r7xp	54	22	"	"	''
cord-283382-t890r7xp	54	23	allowing	allow	VBG
cord-283382-t890r7xp	54	24	the	the	DT
cord-283382-t890r7xp	54	25	stimulation	stimulation	NN
cord-283382-t890r7xp	54	26	of	of	IN
cord-283382-t890r7xp	54	27	multiple	multiple	JJ
cord-283382-t890r7xp	54	28	innate	innate	JJ
cord-283382-t890r7xp	54	29	immune	immune	JJ
cord-283382-t890r7xp	54	30	signaling	signal	VBG
cord-283382-t890r7xp	54	31	pathways	pathway	NNS
cord-283382-t890r7xp	54	32	upon	upon	IN
cord-283382-t890r7xp	54	33	viral	viral	JJ
cord-283382-t890r7xp	54	34	entry	entry	NN
cord-283382-t890r7xp	54	35	,	,	,
cord-283382-t890r7xp	54	36	which	which	WDT
cord-283382-t890r7xp	54	37	can	can	MD
cord-283382-t890r7xp	54	38	augment	augment	VB
cord-283382-t890r7xp	54	39	the	the	DT
cord-283382-t890r7xp	54	40	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	54	41	of	of	IN
cord-283382-t890r7xp	54	42	the	the	DT
cord-283382-t890r7xp	54	43	encoded	encode	VBN
cord-283382-t890r7xp	54	44	Ag	Ag	NNP
cord-283382-t890r7xp	54	45	(	(	-LRB-
cord-283382-t890r7xp	54	46	although	although	IN
cord-283382-t890r7xp	54	47	conversely	conversely	RB
cord-283382-t890r7xp	54	48	,	,	,
cord-283382-t890r7xp	54	49	stimulation	stimulation	NN
cord-283382-t890r7xp	54	50	of	of	IN
cord-283382-t890r7xp	54	51	certain	certain	JJ
cord-283382-t890r7xp	54	52	signaling	signal	VBG
cord-283382-t890r7xp	54	53	pathways	pathway	NNS
cord-283382-t890r7xp	54	54	can	can	MD
cord-283382-t890r7xp	54	55	also	also	RB
cord-283382-t890r7xp	54	56	be	be	VB
cord-283382-t890r7xp	54	57	detrimental	detrimental	JJ
cord-283382-t890r7xp	54	58	to	to	IN
cord-283382-t890r7xp	54	59	their	-PRON-	PRP$
cord-283382-t890r7xp	54	60	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	54	61	,	,	,
cord-283382-t890r7xp	54	62	as	as	IN
cord-283382-t890r7xp	54	63	discussed	discuss	VBN
cord-283382-t890r7xp	54	64	below	below	RB
cord-283382-t890r7xp	54	65	)	)	-RRB-
cord-283382-t890r7xp	54	66	.	.	.
cord-283382-t890r7xp	55	1	Although	although	IN
cord-283382-t890r7xp	55	2	we	-PRON-	PRP
cord-283382-t890r7xp	55	3	have	have	VBP
cord-283382-t890r7xp	55	4	some	some	DT
cord-283382-t890r7xp	55	5	understanding	understanding	NN
cord-283382-t890r7xp	55	6	of	of	IN
cord-283382-t890r7xp	55	7	how	how	WRB
cord-283382-t890r7xp	55	8	individual	individual	JJ
cord-283382-t890r7xp	55	9	pathways	pathway	NNS
cord-283382-t890r7xp	55	10	work	work	VBP
cord-283382-t890r7xp	55	11	in	in	IN
cord-283382-t890r7xp	55	12	vitro	vitro	FW
cord-283382-t890r7xp	55	13	in	in	IN
cord-283382-t890r7xp	55	14	defined	define	VBN
cord-283382-t890r7xp	55	15	cell	cell	NN
cord-283382-t890r7xp	55	16	types	type	NNS
cord-283382-t890r7xp	55	17	(	(	-LRB-
cord-283382-t890r7xp	55	18	i.e.	i.e.	FW
cord-283382-t890r7xp	55	19	,	,	,
cord-283382-t890r7xp	55	20	dendritic	dendritic	JJ
cord-283382-t890r7xp	55	21	cells	cell	NNS
cord-283382-t890r7xp	55	22	,	,	,
cord-283382-t890r7xp	55	23	macrophages	macrophage	NNS
cord-283382-t890r7xp	55	24	)	)	-RRB-
cord-283382-t890r7xp	55	25	,	,	,
cord-283382-t890r7xp	55	26	understanding	understand	VBG
cord-283382-t890r7xp	55	27	how	how	WRB
cord-283382-t890r7xp	55	28	these	these	DT
cord-283382-t890r7xp	55	29	pathways	pathway	NNS
cord-283382-t890r7xp	55	30	intersect	intersect	VBP
cord-283382-t890r7xp	55	31	,	,	,
cord-283382-t890r7xp	55	32	or	or	CC
cord-283382-t890r7xp	55	33	cooperate	cooperate	VB
cord-283382-t890r7xp	55	34	in	in	IN
cord-283382-t890r7xp	55	35	the	the	DT
cord-283382-t890r7xp	55	36	development	development	NN
cord-283382-t890r7xp	55	37	of	of	IN
cord-283382-t890r7xp	55	38	protective	protective	JJ
cord-283382-t890r7xp	55	39	immunity	immunity	NN
cord-283382-t890r7xp	55	40	in	in	IN
cord-283382-t890r7xp	55	41	vivo	vivo	NN
cord-283382-t890r7xp	55	42	,	,	,
cord-283382-t890r7xp	55	43	is	be	VBZ
cord-283382-t890r7xp	55	44	complex	complex	JJ
cord-283382-t890r7xp	55	45	and	and	CC
cord-283382-t890r7xp	55	46	our	-PRON-	PRP$
cord-283382-t890r7xp	55	47	understanding	understanding	NN
cord-283382-t890r7xp	55	48	is	be	VBZ
cord-283382-t890r7xp	55	49	incomplete	incomplete	JJ
cord-283382-t890r7xp	55	50	.	.	.
cord-283382-t890r7xp	56	1	Additionally	additionally	RB
cord-283382-t890r7xp	56	2	,	,	,
cord-283382-t890r7xp	56	3	it	-PRON-	PRP
cord-283382-t890r7xp	56	4	is	be	VBZ
cord-283382-t890r7xp	56	5	apparent	apparent	JJ
cord-283382-t890r7xp	56	6	that	that	IN
cord-283382-t890r7xp	56	7	there	there	EX
cord-283382-t890r7xp	56	8	is	be	VBZ
cord-283382-t890r7xp	56	9	a	a	DT
cord-283382-t890r7xp	56	10	clear	clear	JJ
cord-283382-t890r7xp	56	11	hierarchy	hierarchy	NN
cord-283382-t890r7xp	56	12	of	of	IN
cord-283382-t890r7xp	56	13	immunological	immunological	JJ
cord-283382-t890r7xp	56	14	potency	potency	NN
cord-283382-t890r7xp	56	15	when	when	WRB
cord-283382-t890r7xp	56	16	evaluating	evaluate	VBG
cord-283382-t890r7xp	56	17	distinct	distinct	JJ
cord-283382-t890r7xp	56	18	Ad	ad	NN
cord-283382-t890r7xp	56	19	species	specie	NNS
cord-283382-t890r7xp	56	20	and	and	CC
cord-283382-t890r7xp	56	21	serotypes	serotypes	NN
cord-283382-t890r7xp	56	22	as	as	IN
cord-283382-t890r7xp	56	23	vaccine	vaccine	NN
cord-283382-t890r7xp	56	24	vectors	vector	NNS
cord-283382-t890r7xp	56	25	in	in	IN
cord-283382-t890r7xp	56	26	animal	animal	NN
cord-283382-t890r7xp	56	27	models	model	NNS
cord-283382-t890r7xp	56	28	.	.	.
cord-283382-t890r7xp	57	1	Although	although	IN
cord-283382-t890r7xp	57	2	a	a	DT
cord-283382-t890r7xp	57	3	few	few	JJ
cord-283382-t890r7xp	57	4	selected	select	VBN
cord-283382-t890r7xp	57	5	vectors	vector	NNS
cord-283382-t890r7xp	57	6	display	display	VBP
cord-283382-t890r7xp	57	7	robust	robust	JJ
cord-283382-t890r7xp	57	8	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	57	9	in	in	IN
cord-283382-t890r7xp	57	10	vivo	vivo	NN
cord-283382-t890r7xp	57	11	which	which	WDT
cord-283382-t890r7xp	57	12	is	be	VBZ
cord-283382-t890r7xp	57	13	comparable	comparable	JJ
cord-283382-t890r7xp	57	14	to	to	IN
cord-283382-t890r7xp	57	15	that	that	DT
cord-283382-t890r7xp	57	16	of	of	IN
cord-283382-t890r7xp	57	17	Ad5	ad5	CD
cord-283382-t890r7xp	57	18	,	,	,
cord-283382-t890r7xp	57	19	most	most	JJS
cord-283382-t890r7xp	57	20	are	be	VBP
cord-283382-t890r7xp	57	21	less	less	RBR
cord-283382-t890r7xp	57	22	immunogenic	immunogenic	JJ
cord-283382-t890r7xp	57	23	(	(	-LRB-
cord-283382-t890r7xp	57	24	5	5	CD
cord-283382-t890r7xp	57	25	,	,	,
cord-283382-t890r7xp	57	26	8	8	CD
cord-283382-t890r7xp	57	27	,	,	,
cord-283382-t890r7xp	57	28	15	15	CD
cord-283382-t890r7xp	57	29	,	,	,
cord-283382-t890r7xp	57	30	29	29	CD
cord-283382-t890r7xp	57	31	,	,	,
cord-283382-t890r7xp	57	32	31	31	CD
cord-283382-t890r7xp	57	33	)	)	-RRB-
cord-283382-t890r7xp	57	34	,	,	,
cord-283382-t890r7xp	57	35	and	and	CC
cord-283382-t890r7xp	57	36	there	there	EX
cord-283382-t890r7xp	57	37	are	be	VBP
cord-283382-t890r7xp	57	38	considerable	considerable	JJ
cord-283382-t890r7xp	57	39	differences	difference	NNS
cord-283382-t890r7xp	57	40	in	in	IN
cord-283382-t890r7xp	57	41	the	the	DT
cord-283382-t890r7xp	57	42	phenotype	phenotype	NN
cord-283382-t890r7xp	57	43	and	and	CC
cord-283382-t890r7xp	57	44	functionality	functionality	NN
cord-283382-t890r7xp	57	45	of	of	IN
cord-283382-t890r7xp	57	46	immune	immune	JJ
cord-283382-t890r7xp	57	47	response	response	NN
cord-283382-t890r7xp	57	48	elicited	elicit	VBD
cord-283382-t890r7xp	57	49	(	(	-LRB-
cord-283382-t890r7xp	57	50	8	8	CD
cord-283382-t890r7xp	57	51	,	,	,
cord-283382-t890r7xp	57	52	42	42	CD
cord-283382-t890r7xp	57	53	,	,	,
cord-283382-t890r7xp	57	54	43	43	CD
cord-283382-t890r7xp	57	55	)	)	-RRB-
cord-283382-t890r7xp	57	56	.	.	.
cord-283382-t890r7xp	58	1	In	in	IN
cord-283382-t890r7xp	58	2	recent	recent	JJ
cord-283382-t890r7xp	58	3	years	year	NNS
cord-283382-t890r7xp	58	4	,	,	,
cord-283382-t890r7xp	58	5	investigators	investigator	NNS
cord-283382-t890r7xp	58	6	have	have	VBP
cord-283382-t890r7xp	58	7	begun	begin	VBN
cord-283382-t890r7xp	58	8	to	to	TO
cord-283382-t890r7xp	58	9	identify	identify	VB
cord-283382-t890r7xp	58	10	several	several	JJ
cord-283382-t890r7xp	58	11	crucial	crucial	JJ
cord-283382-t890r7xp	58	12	factors	factor	NNS
cord-283382-t890r7xp	58	13	which	which	WDT
cord-283382-t890r7xp	58	14	could	could	MD
cord-283382-t890r7xp	58	15	contribute	contribute	VB
cord-283382-t890r7xp	58	16	to	to	IN
cord-283382-t890r7xp	58	17	these	these	DT
cord-283382-t890r7xp	58	18	profound	profound	JJ
cord-283382-t890r7xp	58	19	disparities	disparity	NNS
cord-283382-t890r7xp	58	20	in	in	IN
cord-283382-t890r7xp	58	21	immunological	immunological	JJ
cord-283382-t890r7xp	58	22	potency	potency	NN
cord-283382-t890r7xp	58	23	.	.	.
cord-283382-t890r7xp	59	1	It	-PRON-	PRP
cord-283382-t890r7xp	59	2	is	be	VBZ
cord-283382-t890r7xp	59	3	now	now	RB
cord-283382-t890r7xp	59	4	believed	believe	VBN
cord-283382-t890r7xp	59	5	that	that	IN
cord-283382-t890r7xp	59	6	differences	difference	NNS
cord-283382-t890r7xp	59	7	in	in	IN
cord-283382-t890r7xp	59	8	(	(	-LRB-
cord-283382-t890r7xp	59	9	i	i	NN
cord-283382-t890r7xp	59	10	)	)	-RRB-
cord-283382-t890r7xp	59	11	cellular	cellular	JJ
cord-283382-t890r7xp	59	12	receptor	receptor	NN
cord-283382-t890r7xp	59	13	and/or	and/or	CC
cord-283382-t890r7xp	59	14	co	co	JJ
cord-283382-t890r7xp	59	15	-	-	JJ
cord-283382-t890r7xp	59	16	receptor	receptor	JJ
cord-283382-t890r7xp	59	17	usage	usage	NN
cord-283382-t890r7xp	59	18	,	,	,
cord-283382-t890r7xp	59	19	viral	viral	JJ
cord-283382-t890r7xp	59	20	entry	entry	NN
cord-283382-t890r7xp	59	21	,	,	,
cord-283382-t890r7xp	59	22	trafficking	trafficking	NN
cord-283382-t890r7xp	59	23	,	,	,
cord-283382-t890r7xp	59	24	endosomal	endosomal	NNP
cord-283382-t890r7xp	59	25	escape	escape	NN
cord-283382-t890r7xp	59	26	,	,	,
cord-283382-t890r7xp	59	27	and	and	CC
cord-283382-t890r7xp	59	28	in	in	IN
cord-283382-t890r7xp	59	29	vivo	vivo	NN
cord-283382-t890r7xp	59	30	tropism	tropism	NN
cord-283382-t890r7xp	59	31	can	can	MD
cord-283382-t890r7xp	59	32	contribute	contribute	VB
cord-283382-t890r7xp	59	33	to	to	IN
cord-283382-t890r7xp	59	34	the	the	DT
cord-283382-t890r7xp	59	35	(	(	-LRB-
cord-283382-t890r7xp	59	36	ii	ii	NN
cord-283382-t890r7xp	59	37	)	)	-RRB-
cord-283382-t890r7xp	59	38	differential	differential	JJ
cord-283382-t890r7xp	59	39	activation	activation	NN
cord-283382-t890r7xp	59	40	of	of	IN
cord-283382-t890r7xp	59	41	innate	innate	JJ
cord-283382-t890r7xp	59	42	immune	immune	JJ
cord-283382-t890r7xp	59	43	signaling	signaling	NN
cord-283382-t890r7xp	59	44	which	which	WDT
cord-283382-t890r7xp	59	45	influences	influence	VBZ
cord-283382-t890r7xp	59	46	subsequent	subsequent	JJ
cord-283382-t890r7xp	59	47	immune	immune	JJ
cord-283382-t890r7xp	59	48	responses	response	NNS
cord-283382-t890r7xp	59	49	(	(	-LRB-
cord-283382-t890r7xp	59	50	44	44	CD
cord-283382-t890r7xp	59	51	)	)	-RRB-
cord-283382-t890r7xp	59	52	.	.	.
cord-283382-t890r7xp	60	1	In	in	IN
cord-283382-t890r7xp	60	2	addition	addition	NN
cord-283382-t890r7xp	60	3	,	,	,
cord-283382-t890r7xp	60	4	it	-PRON-	PRP
cord-283382-t890r7xp	60	5	is	be	VBZ
cord-283382-t890r7xp	60	6	apparent	apparent	JJ
cord-283382-t890r7xp	60	7	that	that	IN
cord-283382-t890r7xp	60	8	the	the	DT
cord-283382-t890r7xp	60	9	(	(	-LRB-
cord-283382-t890r7xp	60	10	iii	iii	NN
cord-283382-t890r7xp	60	11	)	)	-RRB-
cord-283382-t890r7xp	60	12	magnitude	magnitude	NN
cord-283382-t890r7xp	60	13	and	and	CC
cord-283382-t890r7xp	60	14	persistence	persistence	NN
cord-283382-t890r7xp	60	15	of	of	IN
cord-283382-t890r7xp	60	16	transgene	transgene	JJ
cord-283382-t890r7xp	60	17	expression	expression	NN
cord-283382-t890r7xp	60	18	can	can	MD
cord-283382-t890r7xp	60	19	also	also	RB
cord-283382-t890r7xp	60	20	shape	shape	VB
cord-283382-t890r7xp	60	21	the	the	DT
cord-283382-t890r7xp	60	22	ensuing	ensue	VBG
cord-283382-t890r7xp	60	23	immune	immune	JJ
cord-283382-t890r7xp	60	24	response	response	NN
cord-283382-t890r7xp	60	25	(	(	-LRB-
cord-283382-t890r7xp	60	26	33	33	CD
cord-283382-t890r7xp	60	27	)	)	-RRB-
cord-283382-t890r7xp	60	28	and	and	CC
cord-283382-t890r7xp	60	29	all	all	DT
cord-283382-t890r7xp	60	30	of	of	IN
cord-283382-t890r7xp	60	31	these	these	DT
cord-283382-t890r7xp	60	32	factors	factor	NNS
cord-283382-t890r7xp	60	33	are	be	VBP
cord-283382-t890r7xp	60	34	in	in	IN
cord-283382-t890r7xp	60	35	turn	turn	NN
cord-283382-t890r7xp	60	36	affected	affect	VBN
cord-283382-t890r7xp	60	37	by	by	IN
cord-283382-t890r7xp	60	38	the	the	DT
cord-283382-t890r7xp	60	39	(	(	-LRB-
cord-283382-t890r7xp	60	40	iv	iv	LS
cord-283382-t890r7xp	60	41	)	)	-RRB-
cord-283382-t890r7xp	60	42	vaccine	vaccine	NN
cord-283382-t890r7xp	60	43	dose	dose	NN
cord-283382-t890r7xp	60	44	(	(	-LRB-
cord-283382-t890r7xp	60	45	8)	8)	NN
cord-283382-t890r7xp	60	46	and	and	CC
cord-283382-t890r7xp	60	47	route	route	NN
cord-283382-t890r7xp	60	48	of	of	IN
cord-283382-t890r7xp	60	49	administration	administration	NN
cord-283382-t890r7xp	60	50	(	(	-LRB-
cord-283382-t890r7xp	60	51	45	45	CD
cord-283382-t890r7xp	60	52	)	)	-RRB-
cord-283382-t890r7xp	60	53	.	.	.
cord-283382-t890r7xp	61	1	Increased	increase	VBN
cord-283382-t890r7xp	61	2	understanding	understanding	NN
cord-283382-t890r7xp	61	3	of	of	IN
cord-283382-t890r7xp	61	4	,	,	,
cord-283382-t890r7xp	61	5	and	and	CC
cord-283382-t890r7xp	61	6	implementation	implementation	NN
cord-283382-t890r7xp	61	7	of	of	IN
cord-283382-t890r7xp	61	8	efforts	effort	NNS
cord-283382-t890r7xp	61	9	to	to	TO
cord-283382-t890r7xp	61	10	overcome	overcome	VB
cord-283382-t890r7xp	61	11	these	these	DT
cord-283382-t890r7xp	61	12	striking	strike	VBG
cord-283382-t890r7xp	61	13	differences	difference	NNS
cord-283382-t890r7xp	61	14	in	in	IN
cord-283382-t890r7xp	61	15	immunological	immunological	JJ
cord-283382-t890r7xp	61	16	potency	potency	NN
cord-283382-t890r7xp	61	17	or	or	CC
cord-283382-t890r7xp	61	18	quality	quality	NN
cord-283382-t890r7xp	61	19	,	,	,
cord-283382-t890r7xp	61	20	will	will	MD
cord-283382-t890r7xp	61	21	absolutely	absolutely	RB
cord-283382-t890r7xp	61	22	be	be	VB
cord-283382-t890r7xp	61	23	required	require	VBN
cord-283382-t890r7xp	61	24	for	for	IN
cord-283382-t890r7xp	61	25	the	the	DT
cord-283382-t890r7xp	61	26	development	development	NN
cord-283382-t890r7xp	61	27	of	of	IN
cord-283382-t890r7xp	61	28	optimal	optimal	JJ
cord-283382-t890r7xp	61	29	Ad	ad	NN
cord-283382-t890r7xp	61	30	vectors	vector	NNS
cord-283382-t890r7xp	61	31	for	for	IN
cord-283382-t890r7xp	61	32	clinical	clinical	JJ
cord-283382-t890r7xp	61	33	use	use	NN
cord-283382-t890r7xp	61	34	.	.	.
cord-283382-t890r7xp	62	1	As	as	IN
cord-283382-t890r7xp	62	2	a	a	DT
cord-283382-t890r7xp	62	3	result	result	NN
cord-283382-t890r7xp	62	4	of	of	IN
cord-283382-t890r7xp	62	5	extensive	extensive	JJ
cord-283382-t890r7xp	62	6	study	study	NN
cord-283382-t890r7xp	62	7	over	over	IN
cord-283382-t890r7xp	62	8	the	the	DT
cord-283382-t890r7xp	62	9	past	past	JJ
cord-283382-t890r7xp	62	10	few	few	JJ
cord-283382-t890r7xp	62	11	decades	decade	NNS
cord-283382-t890r7xp	62	12	,	,	,
cord-283382-t890r7xp	62	13	we	-PRON-	PRP
cord-283382-t890r7xp	62	14	have	have	VBP
cord-283382-t890r7xp	62	15	a	a	DT
cord-283382-t890r7xp	62	16	clear	clear	JJ
cord-283382-t890r7xp	62	17	understanding	understanding	NN
cord-283382-t890r7xp	62	18	of	of	IN
cord-283382-t890r7xp	62	19	the	the	DT
cord-283382-t890r7xp	62	20	in	in	FW
cord-283382-t890r7xp	62	21	vitro	vitro	FW
cord-283382-t890r7xp	62	22	tropism	tropism	NN
cord-283382-t890r7xp	62	23	determinants	determinant	NNS
cord-283382-t890r7xp	62	24	of	of	IN
cord-283382-t890r7xp	62	25	vectors	vector	NNS
cord-283382-t890r7xp	62	26	derived	derive	VBN
cord-283382-t890r7xp	62	27	from	from	IN
cord-283382-t890r7xp	62	28	species	specie	NNS
cord-283382-t890r7xp	62	29	C	C	NNP
cord-283382-t890r7xp	62	30	HAdVs	HAdVs	NNP
cord-283382-t890r7xp	62	31	(	(	-LRB-
cord-283382-t890r7xp	62	32	i.e.	i.e.	FW
cord-283382-t890r7xp	62	33	,	,	,
cord-283382-t890r7xp	62	34	HAdV	HAdV	NNP
cord-283382-t890r7xp	62	35	-	-	HYPH
cord-283382-t890r7xp	62	36	C5	C5	NNP
cord-283382-t890r7xp	62	37	/	/	SYM
cord-283382-t890r7xp	62	38	Ad5	Ad5	NNP
cord-283382-t890r7xp	62	39	)	)	-RRB-
cord-283382-t890r7xp	62	40	(	(	-LRB-
cord-283382-t890r7xp	62	41	18	18	CD
cord-283382-t890r7xp	62	42	)	)	-RRB-
cord-283382-t890r7xp	62	43	.	.	.
cord-283382-t890r7xp	63	1	The	the	DT
cord-283382-t890r7xp	63	2	classical	classical	JJ
cord-283382-t890r7xp	63	3	entry	entry	NN
cord-283382-t890r7xp	63	4	pathway	pathway	NN
cord-283382-t890r7xp	63	5	of	of	IN
cord-283382-t890r7xp	63	6	rAd5-based	rad5-based	JJ
cord-283382-t890r7xp	63	7	vectors	vector	NNS
cord-283382-t890r7xp	63	8	in	in	IN
cord-283382-t890r7xp	63	9	non	non	JJ
cord-283382-t890r7xp	63	10	-	-	JJ
cord-283382-t890r7xp	63	11	immune	immune	JJ
cord-283382-t890r7xp	63	12	cells	cell	NNS
cord-283382-t890r7xp	63	13	is	be	VBZ
cord-283382-t890r7xp	63	14	mediated	mediate	VBN
cord-283382-t890r7xp	63	15	by	by	IN
cord-283382-t890r7xp	63	16	binding	bind	VBG
cord-283382-t890r7xp	63	17	of	of	IN
cord-283382-t890r7xp	63	18	the	the	DT
cord-283382-t890r7xp	63	19	fiber	fiber	NN
cord-283382-t890r7xp	63	20	knob	knob	NN
cord-283382-t890r7xp	63	21	domain	domain	NN
cord-283382-t890r7xp	63	22	(	(	-LRB-
cord-283382-t890r7xp	63	23	Figure	figure	NN
cord-283382-t890r7xp	63	24	2	2	CD
cord-283382-t890r7xp	63	25	)	)	-RRB-
cord-283382-t890r7xp	63	26	to	to	IN
cord-283382-t890r7xp	63	27	the	the	DT
cord-283382-t890r7xp	63	28	Coxsackie	Coxsackie	NNP
cord-283382-t890r7xp	63	29	and	and	CC
cord-283382-t890r7xp	63	30	Adenovirus	Adenovirus	NNP
cord-283382-t890r7xp	63	31	receptor	receptor	NN
cord-283382-t890r7xp	63	32	(	(	-LRB-
cord-283382-t890r7xp	63	33	CAR	car	NN
cord-283382-t890r7xp	63	34	)	)	-RRB-
cord-283382-t890r7xp	63	35	.	.	.
cord-283382-t890r7xp	64	1	Following	follow	VBG
cord-283382-t890r7xp	64	2	this	this	DT
cord-283382-t890r7xp	64	3	"	"	``
cord-283382-t890r7xp	64	4	docking	dock	VBG
cord-283382-t890r7xp	64	5	"	"	''
cord-283382-t890r7xp	64	6	interaction	interaction	NN
cord-283382-t890r7xp	64	7	,	,	,
cord-283382-t890r7xp	64	8	viral	viral	JJ
cord-283382-t890r7xp	64	9	internalization	internalization	NN
cord-283382-t890r7xp	64	10	is	be	VBZ
cord-283382-t890r7xp	64	11	facilitated	facilitate	VBN
cord-283382-t890r7xp	64	12	through	through	IN
cord-283382-t890r7xp	64	13	interactions	interaction	NNS
cord-283382-t890r7xp	64	14	between	between	IN
cord-283382-t890r7xp	64	15	the	the	DT
cord-283382-t890r7xp	64	16	arginine	arginine	NN
cord-283382-t890r7xp	64	17	-	-	HYPH
cord-283382-t890r7xp	64	18	glycineaspartate	glycineaspartate	NNP
cord-283382-t890r7xp	64	19	(	(	-LRB-
cord-283382-t890r7xp	64	20	RGD	RGD	NNP
cord-283382-t890r7xp	64	21	)	)	-RRB-
cord-283382-t890r7xp	64	22	motif	motif	NN
cord-283382-t890r7xp	64	23	within	within	IN
cord-283382-t890r7xp	64	24	the	the	DT
cord-283382-t890r7xp	64	25	viral	viral	JJ
cord-283382-t890r7xp	64	26	penton	penton	NNP
cord-283382-t890r7xp	64	27	base	base	NNP
cord-283382-t890r7xp	64	28	and	and	CC
cord-283382-t890r7xp	64	29	cellular	cellular	JJ
cord-283382-t890r7xp	64	30	integrins	integrin	NNS
cord-283382-t890r7xp	64	31	(	(	-LRB-
cord-283382-t890r7xp	64	32	namely	namely	RB
cord-283382-t890r7xp	64	33	αvβ3	αvβ3	NN
cord-283382-t890r7xp	64	34	and	and	CC
cord-283382-t890r7xp	64	35	αvβ5	αvβ5	NNP
cord-283382-t890r7xp	64	36	)	)	-RRB-
cord-283382-t890r7xp	64	37	on	on	IN
cord-283382-t890r7xp	64	38	the	the	DT
cord-283382-t890r7xp	64	39	surface	surface	NN
cord-283382-t890r7xp	64	40	of	of	IN
cord-283382-t890r7xp	64	41	cells	cell	NNS
cord-283382-t890r7xp	64	42	(	(	-LRB-
cord-283382-t890r7xp	64	43	46	46	CD
cord-283382-t890r7xp	64	44	,	,	,
cord-283382-t890r7xp	64	45	47	47	CD
cord-283382-t890r7xp	64	46	)	)	-RRB-
cord-283382-t890r7xp	64	47	.	.	.
cord-283382-t890r7xp	65	1	Adenovirus	Adenovirus	NNP
cord-283382-t890r7xp	65	2	capsid	capsid	NN
cord-283382-t890r7xp	65	3	disassembly	disassembly	NN
cord-283382-t890r7xp	65	4	then	then	RB
cord-283382-t890r7xp	65	5	proceeds	proceed	VBZ
cord-283382-t890r7xp	65	6	in	in	IN
cord-283382-t890r7xp	65	7	a	a	DT
cord-283382-t890r7xp	65	8	systematic	systematic	JJ
cord-283382-t890r7xp	65	9	and	and	CC
cord-283382-t890r7xp	65	10	stepwise	stepwise	JJ
cord-283382-t890r7xp	65	11	process	process	NN
cord-283382-t890r7xp	65	12	.	.	.
cord-283382-t890r7xp	66	1	Initial	initial	JJ
cord-283382-t890r7xp	66	2	binding	binding	NN
cord-283382-t890r7xp	66	3	to	to	IN
cord-283382-t890r7xp	66	4	CAR	car	NN
cord-283382-t890r7xp	66	5	is	be	VBZ
cord-283382-t890r7xp	66	6	a	a	DT
cord-283382-t890r7xp	66	7	motile	motile	JJ
cord-283382-t890r7xp	66	8	interaction	interaction	NN
cord-283382-t890r7xp	66	9	,	,	,
cord-283382-t890r7xp	66	10	whereas	whereas	IN
cord-283382-t890r7xp	66	11	the	the	DT
cord-283382-t890r7xp	66	12	subsequent	subsequent	JJ
cord-283382-t890r7xp	66	13	interaction	interaction	NN
cord-283382-t890r7xp	66	14	with	with	IN
cord-283382-t890r7xp	66	15	immobile	immobile	JJ
cord-283382-t890r7xp	66	16	αv	αv	IN
cord-283382-t890r7xp	66	17	integrins	integrin	NNS
cord-283382-t890r7xp	66	18	results	result	NNS
cord-283382-t890r7xp	66	19	in	in	IN
cord-283382-t890r7xp	66	20	the	the	DT
cord-283382-t890r7xp	66	21	ripping	ripping	NN
cord-283382-t890r7xp	66	22	or	or	CC
cord-283382-t890r7xp	66	23	shedding	shedding	NN
cord-283382-t890r7xp	66	24	of	of	IN
cord-283382-t890r7xp	66	25	fibers	fiber	NNS
cord-283382-t890r7xp	66	26	from	from	IN
cord-283382-t890r7xp	66	27	the	the	DT
cord-283382-t890r7xp	66	28	virion	virion	NN
cord-283382-t890r7xp	66	29	,	,	,
cord-283382-t890r7xp	66	30	initiating	initiate	VBG
cord-283382-t890r7xp	66	31	partial	partial	JJ
cord-283382-t890r7xp	66	32	disassembly	disassembly	NN
cord-283382-t890r7xp	66	33	of	of	IN
cord-283382-t890r7xp	66	34	the	the	DT
cord-283382-t890r7xp	66	35	virion	virion	NN
cord-283382-t890r7xp	66	36	at	at	IN
cord-283382-t890r7xp	66	37	the	the	DT
cord-283382-t890r7xp	66	38	plasma	plasma	NN
cord-283382-t890r7xp	66	39	membrane	membrane	NN
cord-283382-t890r7xp	66	40	(	(	-LRB-
cord-283382-t890r7xp	66	41	48	48	CD
cord-283382-t890r7xp	66	42	,	,	,
cord-283382-t890r7xp	66	43	49	49	CD
cord-283382-t890r7xp	66	44	)	)	-RRB-
cord-283382-t890r7xp	66	45	.	.	.
cord-283382-t890r7xp	67	1	It	-PRON-	PRP
cord-283382-t890r7xp	67	2	was	be	VBD
cord-283382-t890r7xp	67	3	previously	previously	RB
cord-283382-t890r7xp	67	4	believed	believe	VBN
cord-283382-t890r7xp	67	5	that	that	IN
cord-283382-t890r7xp	67	6	endosomal	endosomal	NNP
cord-283382-t890r7xp	67	7	escape	escape	NN
cord-283382-t890r7xp	67	8	was	be	VBD
cord-283382-t890r7xp	67	9	pH	ph	NN
cord-283382-t890r7xp	67	10	-	-	HYPH
cord-283382-t890r7xp	67	11	dependent	dependent	JJ
cord-283382-t890r7xp	67	12	(	(	-LRB-
cord-283382-t890r7xp	67	13	50	50	CD
cord-283382-t890r7xp	67	14	)	)	-RRB-
cord-283382-t890r7xp	67	15	.	.	.
cord-283382-t890r7xp	68	1	However	however	RB
cord-283382-t890r7xp	68	2	,	,	,
cord-283382-t890r7xp	68	3	it	-PRON-	PRP
cord-283382-t890r7xp	68	4	has	have	VBZ
cord-283382-t890r7xp	68	5	subsequently	subsequently	RB
cord-283382-t890r7xp	68	6	been	be	VBN
cord-283382-t890r7xp	68	7	demonstrated	demonstrate	VBN
cord-283382-t890r7xp	68	8	that	that	IN
cord-283382-t890r7xp	68	9	exposure	exposure	NN
cord-283382-t890r7xp	68	10	of	of	IN
cord-283382-t890r7xp	68	11	protein	protein	NN
cord-283382-t890r7xp	68	12	VI	VI	NNP
cord-283382-t890r7xp	68	13	from	from	IN
cord-283382-t890r7xp	68	14	the	the	DT
cord-283382-t890r7xp	68	15	capsid	capsid	JJ
cord-283382-t890r7xp	68	16	interior	interior	NN
cord-283382-t890r7xp	68	17	(	(	-LRB-
cord-283382-t890r7xp	68	18	51	51	CD
cord-283382-t890r7xp	68	19	)	)	-RRB-
cord-283382-t890r7xp	68	20	at	at	IN
cord-283382-t890r7xp	68	21	the	the	DT
cord-283382-t890r7xp	68	22	cell	cell	NN
cord-283382-t890r7xp	68	23	surface	surface	NN
cord-283382-t890r7xp	68	24	,	,	,
cord-283382-t890r7xp	68	25	as	as	IN
cord-283382-t890r7xp	68	26	a	a	DT
cord-283382-t890r7xp	68	27	result	result	NN
cord-283382-t890r7xp	68	28	of	of	IN
cord-283382-t890r7xp	68	29	mechanical	mechanical	JJ
cord-283382-t890r7xp	68	30	strain	strain	NN
cord-283382-t890r7xp	68	31	induced	induce	VBN
cord-283382-t890r7xp	68	32	by	by	IN
cord-283382-t890r7xp	68	33	the	the	DT
cord-283382-t890r7xp	68	34	antagonistic	antagonistic	JJ
cord-283382-t890r7xp	68	35	CAR	car	NN
cord-283382-t890r7xp	68	36	:	:	:
cord-283382-t890r7xp	68	37	integrin	integrin	NN
cord-283382-t890r7xp	68	38	interaction	interaction	NN
cord-283382-t890r7xp	68	39	(	(	-LRB-
cord-283382-t890r7xp	68	40	48	48	CD
cord-283382-t890r7xp	68	41	)	)	-RRB-
cord-283382-t890r7xp	68	42	,	,	,
cord-283382-t890r7xp	68	43	facilitates	facilitate	VBZ
cord-283382-t890r7xp	68	44	access	access	NN
cord-283382-t890r7xp	68	45	to	to	IN
cord-283382-t890r7xp	68	46	the	the	DT
cord-283382-t890r7xp	68	47	cytoplasm	cytoplasm	NN
cord-283382-t890r7xp	68	48	through	through	IN
cord-283382-t890r7xp	68	49	the	the	DT
cord-283382-t890r7xp	68	50	action	action	NN
cord-283382-t890r7xp	68	51	of	of	IN
cord-283382-t890r7xp	68	52	its	-PRON-	PRP$
cord-283382-t890r7xp	68	53	pH	ph	JJ
cord-283382-t890r7xp	68	54	-	-	JJ
cord-283382-t890r7xp	68	55	independent	independent	JJ
cord-283382-t890r7xp	68	56	membrane	membrane	NN
cord-283382-t890r7xp	68	57	lytic	lytic	JJ
cord-283382-t890r7xp	68	58	activity	activity	NN
cord-283382-t890r7xp	68	59	(	(	-LRB-
cord-283382-t890r7xp	68	60	52	52	CD
cord-283382-t890r7xp	68	61	)	)	-RRB-
cord-283382-t890r7xp	68	62	(	(	-LRB-
cord-283382-t890r7xp	68	63	53	53	CD
cord-283382-t890r7xp	68	64	)	)	-RRB-
cord-283382-t890r7xp	68	65	(	(	-LRB-
cord-283382-t890r7xp	68	66	54	54	CD
cord-283382-t890r7xp	68	67	)	)	-RRB-
cord-283382-t890r7xp	68	68	.	.	.
cord-283382-t890r7xp	69	1	Following	follow	VBG
cord-283382-t890r7xp	69	2	endosomal	endosomal	JJ
cord-283382-t890r7xp	69	3	escape	escape	NN
cord-283382-t890r7xp	69	4	,	,	,
cord-283382-t890r7xp	69	5	the	the	DT
cord-283382-t890r7xp	69	6	virion	virion	NN
cord-283382-t890r7xp	69	7	is	be	VBZ
cord-283382-t890r7xp	69	8	transported	transport	VBN
cord-283382-t890r7xp	69	9	to	to	IN
cord-283382-t890r7xp	69	10	the	the	DT
cord-283382-t890r7xp	69	11	nuclear	nuclear	JJ
cord-283382-t890r7xp	69	12	pore	pore	NN
cord-283382-t890r7xp	69	13	complex	complex	NN
cord-283382-t890r7xp	69	14	via	via	IN
cord-283382-t890r7xp	69	15	the	the	DT
cord-283382-t890r7xp	69	16	microtubule	microtubule	JJ
cord-283382-t890r7xp	69	17	network	network	NN
cord-283382-t890r7xp	69	18	(	(	-LRB-
cord-283382-t890r7xp	69	19	50	50	CD
cord-283382-t890r7xp	69	20	,	,	,
cord-283382-t890r7xp	69	21	52	52	CD
cord-283382-t890r7xp	69	22	)	)	-RRB-
cord-283382-t890r7xp	69	23	.	.	.
cord-283382-t890r7xp	70	1	Once	once	IN
cord-283382-t890r7xp	70	2	the	the	DT
cord-283382-t890r7xp	70	3	virion	virion	NN
cord-283382-t890r7xp	70	4	has	have	VBZ
cord-283382-t890r7xp	70	5	docked	dock	VBN
cord-283382-t890r7xp	70	6	at	at	IN
cord-283382-t890r7xp	70	7	the	the	DT
cord-283382-t890r7xp	70	8	nuclear	nuclear	JJ
cord-283382-t890r7xp	70	9	pore	pore	NN
cord-283382-t890r7xp	70	10	complex	complex	NN
cord-283382-t890r7xp	70	11	,	,	,
cord-283382-t890r7xp	70	12	interactions	interaction	NNS
cord-283382-t890r7xp	70	13	with	with	IN
cord-283382-t890r7xp	70	14	cellular	cellular	JJ
cord-283382-t890r7xp	70	15	proteins	protein	NNS
cord-283382-t890r7xp	70	16	trigger	trigger	VBP
cord-283382-t890r7xp	70	17	further	further	RB
cord-283382-t890r7xp	70	18	capsid	capsid	NN
cord-283382-t890r7xp	70	19	disassembly	disassembly	NN
cord-283382-t890r7xp	70	20	and	and	CC
cord-283382-t890r7xp	70	21	allow	allow	VB
cord-283382-t890r7xp	70	22	the	the	DT
cord-283382-t890r7xp	70	23	viral	viral	JJ
cord-283382-t890r7xp	70	24	DNA	dna	NN
cord-283382-t890r7xp	70	25	to	to	TO
cord-283382-t890r7xp	70	26	extrude	extrude	VB
cord-283382-t890r7xp	70	27	into	into	IN
cord-283382-t890r7xp	70	28	the	the	DT
cord-283382-t890r7xp	70	29	nucleus	nucleus	NN
cord-283382-t890r7xp	70	30	for	for	IN
cord-283382-t890r7xp	70	31	subsequent	subsequent	JJ
cord-283382-t890r7xp	70	32	gene	gene	NN
cord-283382-t890r7xp	70	33	expression	expression	NN
cord-283382-t890r7xp	70	34	(	(	-LRB-
cord-283382-t890r7xp	70	35	18	18	CD
cord-283382-t890r7xp	70	36	)	)	-RRB-
cord-283382-t890r7xp	70	37	.	.	.
cord-283382-t890r7xp	71	1	However	however	RB
cord-283382-t890r7xp	71	2	,	,	,
cord-283382-t890r7xp	71	3	unlike	unlike	IN
cord-283382-t890r7xp	71	4	Ad5	ad5	CD
cord-283382-t890r7xp	71	5	,	,	,
cord-283382-t890r7xp	71	6	adenoviral	adenoviral	JJ
cord-283382-t890r7xp	71	7	types	type	NNS
cord-283382-t890r7xp	71	8	derived	derive	VBN
cord-283382-t890r7xp	71	9	from	from	IN
cord-283382-t890r7xp	71	10	species	specie	NNS
cord-283382-t890r7xp	71	11	B	b	NN
cord-283382-t890r7xp	71	12	or	or	CC
cord-283382-t890r7xp	71	13	D	d	NN
cord-283382-t890r7xp	71	14	viruses	virus	NNS
cord-283382-t890r7xp	71	15	such	such	JJ
cord-283382-t890r7xp	71	16	as	as	IN
cord-283382-t890r7xp	71	17	HAdV	HAdV	NNP
cord-283382-t890r7xp	71	18	-	-	HYPH
cord-283382-t890r7xp	71	19	B35	B35	NNP
cord-283382-t890r7xp	71	20	,	,	,
cord-283382-t890r7xp	71	21	HAdV	hadv	NN
cord-283382-t890r7xp	71	22	-	-	HYPH
cord-283382-t890r7xp	71	23	B3	b3	NN
cord-283382-t890r7xp	71	24	,	,	,
cord-283382-t890r7xp	71	25	HAdV	HAdV	NNP
cord-283382-t890r7xp	71	26	-	-	HYPH
cord-283382-t890r7xp	71	27	D11	D11	NNP
cord-283382-t890r7xp	71	28	,	,	,
cord-283382-t890r7xp	71	29	or	or	CC
cord-283382-t890r7xp	71	30	HAdV	HAdV	NNP
cord-283382-t890r7xp	71	31	-	-	HYPH
cord-283382-t890r7xp	71	32	D26	D26	NNP
cord-283382-t890r7xp	71	33	can	can	MD
cord-283382-t890r7xp	71	34	use	use	VB
cord-283382-t890r7xp	71	35	alternative	alternative	JJ
cord-283382-t890r7xp	71	36	binding	binding	NN
cord-283382-t890r7xp	71	37	/	/	SYM
cord-283382-t890r7xp	71	38	entry	entry	NN
cord-283382-t890r7xp	71	39	factors	factor	NNS
cord-283382-t890r7xp	71	40	or	or	CC
cord-283382-t890r7xp	71	41	receptors	receptor	NNS
cord-283382-t890r7xp	71	42	to	to	IN
cord-283382-t890r7xp	71	43	CAR	car	NN
cord-283382-t890r7xp	71	44	,	,	,
cord-283382-t890r7xp	71	45	such	such	JJ
cord-283382-t890r7xp	71	46	as	as	IN
cord-283382-t890r7xp	71	47	CD46	CD46	NNP
cord-283382-t890r7xp	71	48	(	(	-LRB-
cord-283382-t890r7xp	71	49	55	55	CD
cord-283382-t890r7xp	71	50	-	-	SYM
cord-283382-t890r7xp	71	51	57	57	CD
cord-283382-t890r7xp	71	52	)	)	-RRB-
cord-283382-t890r7xp	71	53	,	,	.
cord-283382-t890r7xp	72	1	desmoglein-2	desmoglein-2	NNS
cord-283382-t890r7xp	73	1	(	(	-LRB-
cord-283382-t890r7xp	73	2	DSG-2	DSG-2	NNP
cord-283382-t890r7xp	73	3	)	)	-RRB-
cord-283382-t890r7xp	73	4	(	(	-LRB-
cord-283382-t890r7xp	73	5	58	58	CD
cord-283382-t890r7xp	73	6	)	)	-RRB-
cord-283382-t890r7xp	73	7	,	,	,
cord-283382-t890r7xp	73	8	or	or	CC
cord-283382-t890r7xp	73	9	sialic	sialic	JJ
cord-283382-t890r7xp	73	10	acid	acid	NN
cord-283382-t890r7xp	73	11	(	(	-LRB-
cord-283382-t890r7xp	73	12	59	59	CD
cord-283382-t890r7xp	73	13	)	)	-RRB-
cord-283382-t890r7xp	73	14	.	.	.
cord-283382-t890r7xp	74	1	The	the	DT
cord-283382-t890r7xp	74	2	post	post	JJ
cord-283382-t890r7xp	74	3	-	-	JJ
cord-283382-t890r7xp	74	4	entry	entry	JJ
cord-283382-t890r7xp	74	5	steps	step	NNS
cord-283382-t890r7xp	74	6	of	of	IN
cord-283382-t890r7xp	74	7	these	these	DT
cord-283382-t890r7xp	74	8	rare	rare	JJ
cord-283382-t890r7xp	74	9	species	specie	NNS
cord-283382-t890r7xp	74	10	Ad	ad	NN
cord-283382-t890r7xp	74	11	viruses	virus	NNS
cord-283382-t890r7xp	74	12	in	in	IN
cord-283382-t890r7xp	74	13	diverse	diverse	JJ
cord-283382-t890r7xp	74	14	cell	cell	NN
cord-283382-t890r7xp	74	15	types	type	NNS
cord-283382-t890r7xp	74	16	are	be	VBP
cord-283382-t890r7xp	74	17	not	not	RB
cord-283382-t890r7xp	74	18	as	as	RB
cord-283382-t890r7xp	74	19	well	well	RB
cord-283382-t890r7xp	74	20	-	-	HYPH
cord-283382-t890r7xp	74	21	characterized	characterize	VBN
cord-283382-t890r7xp	74	22	as	as	IN
cord-283382-t890r7xp	74	23	the	the	DT
cord-283382-t890r7xp	74	24	CAR	car	NN
cord-283382-t890r7xp	74	25	-	-	HYPH
cord-283382-t890r7xp	74	26	mediated	mediate	VBN
cord-283382-t890r7xp	74	27	entry	entry	NN
cord-283382-t890r7xp	74	28	of	of	IN
cord-283382-t890r7xp	74	29	Ad5	ad5	CD
cord-283382-t890r7xp	74	30	.	.	.
cord-283382-t890r7xp	75	1	However	however	RB
cord-283382-t890r7xp	75	2	,	,	,
cord-283382-t890r7xp	75	3	it	-PRON-	PRP
cord-283382-t890r7xp	75	4	is	be	VBZ
cord-283382-t890r7xp	75	5	considered	consider	VBN
cord-283382-t890r7xp	75	6	that	that	IN
cord-283382-t890r7xp	75	7	the	the	DT
cord-283382-t890r7xp	75	8	use	use	NN
cord-283382-t890r7xp	75	9	of	of	IN
cord-283382-t890r7xp	75	10	alternative	alternative	JJ
cord-283382-t890r7xp	75	11	entry	entry	NN
cord-283382-t890r7xp	75	12	pathways	pathway	NNS
cord-283382-t890r7xp	75	13	or	or	CC
cord-283382-t890r7xp	75	14	different	different	JJ
cord-283382-t890r7xp	75	15	receptors	receptor	NNS
cord-283382-t890r7xp	75	16	can	can	MD
cord-283382-t890r7xp	75	17	not	not	RB
cord-283382-t890r7xp	75	18	only	only	RB
cord-283382-t890r7xp	75	19	result	result	VB
cord-283382-t890r7xp	75	20	in	in	IN
cord-283382-t890r7xp	75	21	differences	difference	NNS
cord-283382-t890r7xp	75	22	in	in	IN
cord-283382-t890r7xp	75	23	endosomal	endosomal	NNP
cord-283382-t890r7xp	75	24	escape	escape	NN
cord-283382-t890r7xp	75	25	,	,	,
cord-283382-t890r7xp	75	26	trafficking	traffic	VBG
cord-283382-t890r7xp	75	27	to	to	IN
cord-283382-t890r7xp	75	28	the	the	DT
cord-283382-t890r7xp	75	29	nucleus	nucleus	NN
cord-283382-t890r7xp	75	30	and	and	CC
cord-283382-t890r7xp	75	31	subsequent	subsequent	JJ
cord-283382-t890r7xp	75	32	transgene	transgene	NN
cord-283382-t890r7xp	75	33	expression	expression	NN
cord-283382-t890r7xp	75	34	(	(	-LRB-
cord-283382-t890r7xp	75	35	60	60	CD
cord-283382-t890r7xp	75	36	)	)	-RRB-
cord-283382-t890r7xp	75	37	,	,	,
cord-283382-t890r7xp	75	38	but	but	CC
cord-283382-t890r7xp	75	39	can	can	MD
cord-283382-t890r7xp	75	40	also	also	RB
cord-283382-t890r7xp	75	41	impact	impact	VB
cord-283382-t890r7xp	75	42	on	on	IN
cord-283382-t890r7xp	75	43	the	the	DT
cord-283382-t890r7xp	75	44	in	in	IN
cord-283382-t890r7xp	75	45	vivo	vivo	NN
cord-283382-t890r7xp	75	46	tropism	tropism	NN
cord-283382-t890r7xp	75	47	of	of	IN
cord-283382-t890r7xp	75	48	the	the	DT
cord-283382-t890r7xp	75	49	vector	vector	NN
cord-283382-t890r7xp	75	50	following	follow	VBG
cord-283382-t890r7xp	75	51	different	different	JJ
cord-283382-t890r7xp	75	52	routes	route	NNS
cord-283382-t890r7xp	75	53	of	of	IN
cord-283382-t890r7xp	75	54	vaccine	vaccine	NN
cord-283382-t890r7xp	75	55	administration	administration	NN
cord-283382-t890r7xp	75	56	(	(	-LRB-
cord-283382-t890r7xp	75	57	i.e.	i.e.	FW
cord-283382-t890r7xp	75	58	,	,	,
cord-283382-t890r7xp	75	59	intramuscular	intramuscular	JJ
cord-283382-t890r7xp	75	60	vs.	vs.	FW
cord-283382-t890r7xp	75	61	intranasal	intranasal	NN
cord-283382-t890r7xp	75	62	)	)	-RRB-
cord-283382-t890r7xp	75	63	.	.	.
cord-283382-t890r7xp	76	1	As	as	IN
cord-283382-t890r7xp	76	2	a	a	DT
cord-283382-t890r7xp	76	3	result	result	NN
cord-283382-t890r7xp	76	4	,	,	,
cord-283382-t890r7xp	76	5	triggering	trigger	VBG
cord-283382-t890r7xp	76	6	of	of	IN
cord-283382-t890r7xp	76	7	innate	innate	JJ
cord-283382-t890r7xp	76	8	immune	immune	JJ
cord-283382-t890r7xp	76	9	signaling	signal	VBG
cord-283382-t890r7xp	76	10	pathways	pathway	NNS
cord-283382-t890r7xp	76	11	may	may	MD
cord-283382-t890r7xp	76	12	also	also	RB
cord-283382-t890r7xp	76	13	differ	differ	VB
cord-283382-t890r7xp	76	14	at	at	IN
cord-283382-t890r7xp	76	15	each	each	DT
cord-283382-t890r7xp	76	16	step	step	NN
cord-283382-t890r7xp	76	17	of	of	IN
cord-283382-t890r7xp	76	18	the	the	DT
cord-283382-t890r7xp	76	19	entry	entry	NN
cord-283382-t890r7xp	76	20	process	process	NN
cord-283382-t890r7xp	76	21	(	(	-LRB-
cord-283382-t890r7xp	76	22	33	33	CD
cord-283382-t890r7xp	76	23	,	,	,
cord-283382-t890r7xp	76	24	61	61	CD
cord-283382-t890r7xp	76	25	)	)	-RRB-
cord-283382-t890r7xp	76	26	.	.	.
cord-283382-t890r7xp	77	1	Less	less	RBR
cord-283382-t890r7xp	77	2	efficient	efficient	JJ
cord-283382-t890r7xp	77	3	trafficking	traffic	VBG
cord-283382-t890r7xp	77	4	pathways	pathway	NNS
cord-283382-t890r7xp	77	5	could	could	MD
cord-283382-t890r7xp	77	6	result	result	VB
cord-283382-t890r7xp	77	7	in	in	IN
cord-283382-t890r7xp	77	8	weak	weak	JJ
cord-283382-t890r7xp	77	9	or	or	CC
cord-283382-t890r7xp	77	10	limited	limited	JJ
cord-283382-t890r7xp	77	11	induction	induction	NN
cord-283382-t890r7xp	77	12	of	of	IN
cord-283382-t890r7xp	77	13	cytokines	cytokine	NNS
cord-283382-t890r7xp	77	14	/	/	SYM
cord-283382-t890r7xp	77	15	chemokines	chemokine	NNS
cord-283382-t890r7xp	77	16	(	(	-LRB-
cord-283382-t890r7xp	77	17	62	62	CD
cord-283382-t890r7xp	77	18	)	)	-RRB-
cord-283382-t890r7xp	77	19	,	,	,
cord-283382-t890r7xp	77	20	or	or	CC
cord-283382-t890r7xp	77	21	increased	increase	VBN
cord-283382-t890r7xp	77	22	uptake	uptake	NN
cord-283382-t890r7xp	77	23	in	in	IN
cord-283382-t890r7xp	77	24	cell	cell	NN
cord-283382-t890r7xp	77	25	types	type	NNS
cord-283382-t890r7xp	77	26	which	which	WDT
cord-283382-t890r7xp	77	27	result	result	VBP
cord-283382-t890r7xp	77	28	in	in	IN
cord-283382-t890r7xp	77	29	vector	vector	NN
cord-283382-t890r7xp	77	30	degradation	degradation	NN
cord-283382-t890r7xp	77	31	with	with	IN
cord-283382-t890r7xp	77	32	minimal	minimal	JJ
cord-283382-t890r7xp	77	33	transgene	transgene	NN
cord-283382-t890r7xp	77	34	expression	expression	NN
cord-283382-t890r7xp	77	35	(	(	-LRB-
cord-283382-t890r7xp	77	36	63	63	CD
cord-283382-t890r7xp	77	37	)	)	-RRB-
cord-283382-t890r7xp	77	38	(	(	-LRB-
cord-283382-t890r7xp	77	39	64	64	CD
cord-283382-t890r7xp	77	40	)	)	-RRB-
cord-283382-t890r7xp	77	41	(	(	-LRB-
cord-283382-t890r7xp	77	42	65	65	CD
cord-283382-t890r7xp	77	43	)	)	-RRB-
cord-283382-t890r7xp	77	44	(	(	-LRB-
cord-283382-t890r7xp	77	45	66	66	CD
cord-283382-t890r7xp	77	46	)	)	-RRB-
cord-283382-t890r7xp	77	47	.	.	.
cord-283382-t890r7xp	78	1	Consequently	consequently	RB
cord-283382-t890r7xp	78	2	,	,	,
cord-283382-t890r7xp	78	3	such	such	JJ
cord-283382-t890r7xp	78	4	differences	difference	NNS
cord-283382-t890r7xp	78	5	between	between	IN
cord-283382-t890r7xp	78	6	diverse	diverse	JJ
cord-283382-t890r7xp	78	7	Ad	ad	NN
cord-283382-t890r7xp	78	8	vectors	vector	NNS
cord-283382-t890r7xp	78	9	can	can	MD
cord-283382-t890r7xp	78	10	impact	impact	VB
cord-283382-t890r7xp	78	11	on	on	IN
cord-283382-t890r7xp	78	12	the	the	DT
cord-283382-t890r7xp	78	13	magnitude	magnitude	NN
cord-283382-t890r7xp	78	14	and	and	CC
cord-283382-t890r7xp	78	15	phenotype	phenotype	NN
cord-283382-t890r7xp	78	16	of	of	IN
cord-283382-t890r7xp	78	17	the	the	DT
cord-283382-t890r7xp	78	18	ensuing	ensue	VBG
cord-283382-t890r7xp	78	19	adaptive	adaptive	JJ
cord-283382-t890r7xp	78	20	immune	immune	JJ
cord-283382-t890r7xp	78	21	response	response	NN
cord-283382-t890r7xp	78	22	when	when	WRB
cord-283382-t890r7xp	78	23	they	-PRON-	PRP
cord-283382-t890r7xp	78	24	are	be	VBP
cord-283382-t890r7xp	78	25	used	use	VBN
cord-283382-t890r7xp	78	26	as	as	IN
cord-283382-t890r7xp	78	27	a	a	DT
cord-283382-t890r7xp	78	28	vaccine	vaccine	NN
cord-283382-t890r7xp	78	29	platform	platform	NN
cord-283382-t890r7xp	78	30	(	(	-LRB-
cord-283382-t890r7xp	78	31	8	8	CD
cord-283382-t890r7xp	78	32	,	,	,
cord-283382-t890r7xp	78	33	33	33	CD
cord-283382-t890r7xp	78	34	,	,	,
cord-283382-t890r7xp	78	35	44	44	CD
cord-283382-t890r7xp	78	36	)	)	-RRB-
cord-283382-t890r7xp	78	37	.	.	.
cord-283382-t890r7xp	79	1	Macrophages	macrophage	NNS
cord-283382-t890r7xp	79	2	.	.	.
cord-283382-t890r7xp	80	1	In	in	IN
cord-283382-t890r7xp	80	2	addition	addition	NN
cord-283382-t890r7xp	80	3	to	to	IN
cord-283382-t890r7xp	80	4	the	the	DT
cord-283382-t890r7xp	80	5	classical	classical	JJ
cord-283382-t890r7xp	80	6	in	in	IN
cord-283382-t890r7xp	80	7	vitro	vitro	FW
cord-283382-t890r7xp	80	8	entry	entry	NN
cord-283382-t890r7xp	80	9	pathways	pathway	NNS
cord-283382-t890r7xp	80	10	described	describe	VBN
cord-283382-t890r7xp	80	11	above	above	RB
cord-283382-t890r7xp	80	12	,	,	,
cord-283382-t890r7xp	80	13	Ad	ad	NN
cord-283382-t890r7xp	80	14	vectors	vector	NNS
cord-283382-t890r7xp	80	15	can	can	MD
cord-283382-t890r7xp	80	16	infect	infect	VB
cord-283382-t890r7xp	80	17	mononuclear	mononuclear	JJ
cord-283382-t890r7xp	80	18	phagocytes	phagocyte	NNS
cord-283382-t890r7xp	80	19	efficiently	efficiently	RB
cord-283382-t890r7xp	80	20	both	both	DT
cord-283382-t890r7xp	80	21	in	in	IN
cord-283382-t890r7xp	80	22	vitro	vitro	FW
cord-283382-t890r7xp	80	23	and	and	CC
cord-283382-t890r7xp	80	24	in	in	IN
cord-283382-t890r7xp	80	25	vivo	vivo	NN
cord-283382-t890r7xp	80	26	,	,	,
cord-283382-t890r7xp	80	27	independently	independently	RB
cord-283382-t890r7xp	80	28	of	of	IN
cord-283382-t890r7xp	80	29	their	-PRON-	PRP$
cord-283382-t890r7xp	80	30	described	describe	VBN
cord-283382-t890r7xp	80	31	surface	surface	NN
cord-283382-t890r7xp	80	32	receptors	receptor	NNS
cord-283382-t890r7xp	80	33	(	(	-LRB-
cord-283382-t890r7xp	80	34	i.e.	i.e.	FW
cord-283382-t890r7xp	80	35	,	,	,
cord-283382-t890r7xp	80	36	CAR	car	NN
cord-283382-t890r7xp	80	37	,	,	,
cord-283382-t890r7xp	80	38	DSG-2	DSG-2	NNP
cord-283382-t890r7xp	80	39	)	)	-RRB-
cord-283382-t890r7xp	80	40	(	(	-LRB-
cord-283382-t890r7xp	80	41	67	67	CD
cord-283382-t890r7xp	80	42	)	)	-RRB-
cord-283382-t890r7xp	80	43	,	,	,
cord-283382-t890r7xp	80	44	which	which	WDT
cord-283382-t890r7xp	80	45	are	be	VBP
cord-283382-t890r7xp	80	46	absent	absent	JJ
cord-283382-t890r7xp	80	47	on	on	IN
cord-283382-t890r7xp	80	48	murine	murine	JJ
cord-283382-t890r7xp	80	49	macrophages	macrophage	NNS
cord-283382-t890r7xp	80	50	.	.	.
cord-283382-t890r7xp	81	1	In	in	IN
cord-283382-t890r7xp	81	2	vivo	vivo	NN
cord-283382-t890r7xp	81	3	interactions	interaction	NNS
cord-283382-t890r7xp	81	4	with	with	IN
cord-283382-t890r7xp	81	5	tissue	tissue	NN
cord-283382-t890r7xp	81	6	resident	resident	NN
cord-283382-t890r7xp	81	7	macrophages	macrophage	NNS
cord-283382-t890r7xp	81	8	,	,	,
cord-283382-t890r7xp	81	9	such	such	JJ
cord-283382-t890r7xp	81	10	as	as	IN
cord-283382-t890r7xp	81	11	Kupffer	Kupffer	NNP
cord-283382-t890r7xp	81	12	cells	cell	NNS
cord-283382-t890r7xp	81	13	in	in	IN
cord-283382-t890r7xp	81	14	the	the	DT
cord-283382-t890r7xp	81	15	liver	liver	NN
cord-283382-t890r7xp	81	16	or	or	CC
cord-283382-t890r7xp	81	17	alveolar	alveolar	NN
cord-283382-t890r7xp	81	18	macrophages	macrophage	NNS
cord-283382-t890r7xp	81	19	in	in	IN
cord-283382-t890r7xp	81	20	the	the	DT
cord-283382-t890r7xp	81	21	lung	lung	NN
cord-283382-t890r7xp	81	22	,	,	,
cord-283382-t890r7xp	81	23	can	can	MD
cord-283382-t890r7xp	81	24	result	result	VB
cord-283382-t890r7xp	81	25	in	in	IN
cord-283382-t890r7xp	81	26	scavenging	scavenging	NN
cord-283382-t890r7xp	81	27	and	and	CC
cord-283382-t890r7xp	81	28	degradation	degradation	NN
cord-283382-t890r7xp	81	29	of	of	IN
cord-283382-t890r7xp	81	30	significant	significant	JJ
cord-283382-t890r7xp	81	31	amounts	amount	NNS
cord-283382-t890r7xp	81	32	of	of	IN
cord-283382-t890r7xp	81	33	input	input	NN
cord-283382-t890r7xp	81	34	Ad	ad	NN
cord-283382-t890r7xp	81	35	vector	vector	NN
cord-283382-t890r7xp	81	36	(	(	-LRB-
cord-283382-t890r7xp	81	37	64	64	CD
cord-283382-t890r7xp	81	38	)	)	-RRB-
cord-283382-t890r7xp	81	39	(	(	-LRB-
cord-283382-t890r7xp	81	40	65	65	CD
cord-283382-t890r7xp	81	41	)	)	-RRB-
cord-283382-t890r7xp	81	42	(	(	-LRB-
cord-283382-t890r7xp	81	43	66	66	CD
cord-283382-t890r7xp	81	44	)	)	-RRB-
cord-283382-t890r7xp	81	45	.	.	.
cord-283382-t890r7xp	82	1	Not	not	RB
cord-283382-t890r7xp	82	2	only	only	RB
cord-283382-t890r7xp	82	3	can	can	MD
cord-283382-t890r7xp	82	4	these	these	DT
cord-283382-t890r7xp	82	5	interactions	interaction	NNS
cord-283382-t890r7xp	82	6	result	result	VB
cord-283382-t890r7xp	82	7	in	in	IN
cord-283382-t890r7xp	82	8	limited	limited	JJ
cord-283382-t890r7xp	82	9	transgene	transgene	NN
cord-283382-t890r7xp	82	10	expression	expression	NN
cord-283382-t890r7xp	82	11	which	which	WDT
cord-283382-t890r7xp	82	12	could	could	MD
cord-283382-t890r7xp	82	13	affect	affect	VB
cord-283382-t890r7xp	82	14	the	the	DT
cord-283382-t890r7xp	82	15	therapeutic	therapeutic	JJ
cord-283382-t890r7xp	82	16	efficacy	efficacy	NN
cord-283382-t890r7xp	82	17	,	,	,
cord-283382-t890r7xp	82	18	but	but	CC
cord-283382-t890r7xp	82	19	the	the	DT
cord-283382-t890r7xp	82	20	phagocytosis	phagocytosis	NN
cord-283382-t890r7xp	82	21	of	of	IN
cord-283382-t890r7xp	82	22	Ad	ad	NN
cord-283382-t890r7xp	82	23	particles	particle	NNS
cord-283382-t890r7xp	82	24	can	can	MD
cord-283382-t890r7xp	82	25	trigger	trigger	VB
cord-283382-t890r7xp	82	26	inflammatory	inflammatory	JJ
cord-283382-t890r7xp	82	27	responses	response	NNS
cord-283382-t890r7xp	82	28	(	(	-LRB-
cord-283382-t890r7xp	82	29	68	68	CD
cord-283382-t890r7xp	82	30	,	,	,
cord-283382-t890r7xp	82	31	69	69	CD
cord-283382-t890r7xp	82	32	)	)	-RRB-
cord-283382-t890r7xp	82	33	,	,	,
cord-283382-t890r7xp	82	34	leading	lead	VBG
cord-283382-t890r7xp	82	35	to	to	IN
cord-283382-t890r7xp	82	36	undesirable	undesirable	JJ
cord-283382-t890r7xp	82	37	off	off	RP
cord-283382-t890r7xp	82	38	-	-	HYPH
cord-283382-t890r7xp	82	39	target	target	NN
cord-283382-t890r7xp	82	40	toxicity	toxicity	NN
cord-283382-t890r7xp	82	41	(	(	-LRB-
cord-283382-t890r7xp	82	42	70	70	CD
cord-283382-t890r7xp	82	43	)	)	-RRB-
cord-283382-t890r7xp	82	44	.	.	.
cord-283382-t890r7xp	83	1	This	this	DT
cord-283382-t890r7xp	83	2	is	be	VBZ
cord-283382-t890r7xp	83	3	a	a	DT
cord-283382-t890r7xp	83	4	particularly	particularly	RB
cord-283382-t890r7xp	83	5	important	important	JJ
cord-283382-t890r7xp	83	6	consideration	consideration	NN
cord-283382-t890r7xp	83	7	for	for	IN
cord-283382-t890r7xp	83	8	therapeutic	therapeutic	JJ
cord-283382-t890r7xp	83	9	applications	application	NNS
cord-283382-t890r7xp	83	10	which	which	WDT
cord-283382-t890r7xp	83	11	require	require	VBP
cord-283382-t890r7xp	83	12	systemic	systemic	JJ
cord-283382-t890r7xp	83	13	administration	administration	NN
cord-283382-t890r7xp	83	14	or	or	CC
cord-283382-t890r7xp	83	15	are	be	VBP
cord-283382-t890r7xp	83	16	designed	design	VBN
cord-283382-t890r7xp	83	17	for	for	IN
cord-283382-t890r7xp	83	18	use	use	NN
cord-283382-t890r7xp	83	19	in	in	IN
cord-283382-t890r7xp	83	20	immunocompromised	immunocompromised	JJ
cord-283382-t890r7xp	83	21	individuals	individual	NNS
cord-283382-t890r7xp	83	22	(	(	-LRB-
cord-283382-t890r7xp	83	23	i.e.	i.e.	FW
cord-283382-t890r7xp	83	24	,	,	,
cord-283382-t890r7xp	83	25	oncolytic	oncolytic	JJ
cord-283382-t890r7xp	83	26	viral	viral	JJ
cord-283382-t890r7xp	83	27	therapy	therapy	NN
cord-283382-t890r7xp	83	28	for	for	IN
cord-283382-t890r7xp	83	29	disseminated	disseminate	VBN
cord-283382-t890r7xp	83	30	metastases	metastasis	NNS
cord-283382-t890r7xp	83	31	)	)	-RRB-
cord-283382-t890r7xp	83	32	(	(	-LRB-
cord-283382-t890r7xp	83	33	18	18	CD
cord-283382-t890r7xp	83	34	)	)	-RRB-
cord-283382-t890r7xp	83	35	.	.	.
cord-283382-t890r7xp	84	1	As	as	IN
cord-283382-t890r7xp	84	2	a	a	DT
cord-283382-t890r7xp	84	3	result	result	NN
cord-283382-t890r7xp	84	4	,	,	,
cord-283382-t890r7xp	84	5	efforts	effort	NNS
cord-283382-t890r7xp	84	6	have	have	VBP
cord-283382-t890r7xp	84	7	been	be	VBN
cord-283382-t890r7xp	84	8	made	make	VBN
cord-283382-t890r7xp	84	9	to	to	TO
cord-283382-t890r7xp	84	10	characterize	characterize	VB
cord-283382-t890r7xp	84	11	the	the	DT
cord-283382-t890r7xp	84	12	mechanisms	mechanism	NNS
cord-283382-t890r7xp	84	13	of	of	IN
cord-283382-t890r7xp	84	14	Ad	ad	NN
cord-283382-t890r7xp	84	15	viral	viral	JJ
cord-283382-t890r7xp	84	16	entry	entry	NN
cord-283382-t890r7xp	84	17	in	in	IN
cord-283382-t890r7xp	84	18	macrophages	macrophage	NNS
cord-283382-t890r7xp	84	19	and	and	CC
cord-283382-t890r7xp	84	20	to	to	TO
cord-283382-t890r7xp	84	21	better	better	RB
cord-283382-t890r7xp	84	22	understand	understand	VB
cord-283382-t890r7xp	84	23	how	how	WRB
cord-283382-t890r7xp	84	24	these	these	DT
cord-283382-t890r7xp	84	25	interactions	interaction	NNS
cord-283382-t890r7xp	84	26	contribute	contribute	VBP
cord-283382-t890r7xp	84	27	to	to	IN
cord-283382-t890r7xp	84	28	the	the	DT
cord-283382-t890r7xp	84	29	induction	induction	NN
cord-283382-t890r7xp	84	30	of	of	IN
cord-283382-t890r7xp	84	31	inflammatory	inflammatory	JJ
cord-283382-t890r7xp	84	32	responses	response	NNS
cord-283382-t890r7xp	84	33	within	within	IN
cord-283382-t890r7xp	84	34	defined	define	VBN
cord-283382-t890r7xp	84	35	anatomical	anatomical	JJ
cord-283382-t890r7xp	84	36	compartments	compartment	NNS
cord-283382-t890r7xp	84	37	following	follow	VBG
cord-283382-t890r7xp	84	38	different	different	JJ
cord-283382-t890r7xp	84	39	routes	route	NNS
cord-283382-t890r7xp	84	40	of	of	IN
cord-283382-t890r7xp	84	41	administration	administration	NN
cord-283382-t890r7xp	84	42	(	(	-LRB-
cord-283382-t890r7xp	84	43	i.e.	i.e.	FW
cord-283382-t890r7xp	84	44	,	,	,
cord-283382-t890r7xp	84	45	intramuscular	intramuscular	JJ
cord-283382-t890r7xp	84	46	,	,	,
cord-283382-t890r7xp	84	47	intranasal	intranasal	NN
cord-283382-t890r7xp	84	48	vs.	vs.	IN
cord-283382-t890r7xp	84	49	intravenous	intravenous	JJ
cord-283382-t890r7xp	84	50	)	)	-RRB-
cord-283382-t890r7xp	84	51	.	.	.
cord-283382-t890r7xp	85	1	Opsonization	opsonization	NN
cord-283382-t890r7xp	85	2	of	of	IN
cord-283382-t890r7xp	85	3	Ad	ad	NN
cord-283382-t890r7xp	85	4	viral	viral	JJ
cord-283382-t890r7xp	85	5	particles	particle	NNS
cord-283382-t890r7xp	85	6	by	by	IN
cord-283382-t890r7xp	85	7	complement	complement	NN
cord-283382-t890r7xp	85	8	or	or	CC
cord-283382-t890r7xp	85	9	antibodies	antibody	NNS
cord-283382-t890r7xp	85	10	(	(	-LRB-
cord-283382-t890r7xp	85	11	natural	natural	JJ
cord-283382-t890r7xp	85	12	or	or	CC
cord-283382-t890r7xp	85	13	anti	anti	JJ
cord-283382-t890r7xp	85	14	-	-	JJ
cord-283382-t890r7xp	85	15	viral	viral	JJ
cord-283382-t890r7xp	85	16	)	)	-RRB-
cord-283382-t890r7xp	85	17	can	can	MD
cord-283382-t890r7xp	85	18	bridge	bridge	VB
cord-283382-t890r7xp	85	19	entry	entry	NN
cord-283382-t890r7xp	85	20	into	into	IN
cord-283382-t890r7xp	85	21	macrophages	macrophage	NNS
cord-283382-t890r7xp	85	22	by	by	IN
cord-283382-t890r7xp	85	23	engaging	engage	VBG
cord-283382-t890r7xp	85	24	Fc	Fc	NNP
cord-283382-t890r7xp	85	25	-	-	HYPH
cord-283382-t890r7xp	85	26	receptors	receptor	NNS
cord-283382-t890r7xp	85	27	(	(	-LRB-
cord-283382-t890r7xp	85	28	FcRs	FcRs	NNP
cord-283382-t890r7xp	85	29	)	)	-RRB-
cord-283382-t890r7xp	85	30	or	or	CC
cord-283382-t890r7xp	85	31	complement	complement	VB
cord-283382-t890r7xp	85	32	receptors	receptor	NNS
cord-283382-t890r7xp	85	33	(	(	-LRB-
cord-283382-t890r7xp	85	34	71	71	CD
cord-283382-t890r7xp	85	35	)	)	-RRB-
cord-283382-t890r7xp	85	36	(	(	-LRB-
cord-283382-t890r7xp	85	37	72	72	CD
cord-283382-t890r7xp	85	38	)	)	-RRB-
cord-283382-t890r7xp	85	39	(	(	-LRB-
cord-283382-t890r7xp	85	40	73	73	CD
cord-283382-t890r7xp	85	41	)	)	-RRB-
cord-283382-t890r7xp	85	42	.	.	.
cord-283382-t890r7xp	86	1	Additionally	additionally	RB
cord-283382-t890r7xp	86	2	,	,	,
cord-283382-t890r7xp	86	3	a	a	DT
cord-283382-t890r7xp	86	4	role	role	NN
cord-283382-t890r7xp	86	5	for	for	IN
cord-283382-t890r7xp	86	6	scavenging	scavenge	VBG
cord-283382-t890r7xp	86	7	receptors	receptor	NNS
cord-283382-t890r7xp	86	8	in	in	IN
cord-283382-t890r7xp	86	9	facilitating	facilitate	VBG
cord-283382-t890r7xp	86	10	viral	viral	JJ
cord-283382-t890r7xp	86	11	entry	entry	NN
cord-283382-t890r7xp	86	12	into	into	IN
cord-283382-t890r7xp	86	13	murine	murine	JJ
cord-283382-t890r7xp	86	14	macrophages	macrophage	NNS
cord-283382-t890r7xp	86	15	,	,	,
cord-283382-t890r7xp	86	16	both	both	CC
cord-283382-t890r7xp	86	17	in	in	IN
cord-283382-t890r7xp	86	18	vitro	vitro	FW
cord-283382-t890r7xp	86	19	and	and	CC
cord-283382-t890r7xp	86	20	in	in	IN
cord-283382-t890r7xp	86	21	vivo	vivo	NNP
cord-283382-t890r7xp	86	22	,	,	,
cord-283382-t890r7xp	86	23	has	have	VBZ
cord-283382-t890r7xp	86	24	been	be	VBN
cord-283382-t890r7xp	86	25	outlined	outline	VBN
cord-283382-t890r7xp	86	26	(	(	-LRB-
cord-283382-t890r7xp	86	27	62	62	CD
cord-283382-t890r7xp	86	28	,	,	,
cord-283382-t890r7xp	86	29	67	67	CD
cord-283382-t890r7xp	86	30	,	,	,
cord-283382-t890r7xp	86	31	74	74	CD
cord-283382-t890r7xp	86	32	)	)	-RRB-
cord-283382-t890r7xp	86	33	.	.	.
cord-283382-t890r7xp	87	1	Scavenging	scavenging	NN
cord-283382-t890r7xp	87	2	receptors	receptor	NNS
cord-283382-t890r7xp	87	3	are	be	VBP
cord-283382-t890r7xp	87	4	a	a	DT
cord-283382-t890r7xp	87	5	heterogenous	heterogenous	JJ
cord-283382-t890r7xp	87	6	and	and	CC
cord-283382-t890r7xp	87	7	structurally	structurally	RB
cord-283382-t890r7xp	87	8	diverse	diverse	JJ
cord-283382-t890r7xp	87	9	family	family	NN
cord-283382-t890r7xp	87	10	of	of	IN
cord-283382-t890r7xp	87	11	receptors	receptor	NNS
cord-283382-t890r7xp	87	12	capable	capable	JJ
cord-283382-t890r7xp	87	13	of	of	IN
cord-283382-t890r7xp	87	14	interacting	interact	VBG
cord-283382-t890r7xp	87	15	with	with	IN
cord-283382-t890r7xp	87	16	endogenous	endogenous	JJ
cord-283382-t890r7xp	87	17	proteins	protein	NNS
cord-283382-t890r7xp	87	18	and	and	CC
cord-283382-t890r7xp	87	19	lipids	lipid	NNS
cord-283382-t890r7xp	87	20	,	,	,
cord-283382-t890r7xp	87	21	microbial	microbial	JJ
cord-283382-t890r7xp	87	22	ligands	ligand	NNS
cord-283382-t890r7xp	87	23	,	,	,
cord-283382-t890r7xp	87	24	and	and	CC
cord-283382-t890r7xp	87	25	non	non	JJ
cord-283382-t890r7xp	87	26	-	-	JJ
cord-283382-t890r7xp	87	27	opsonized	opsonized	JJ
cord-283382-t890r7xp	87	28	particles	particle	NNS
cord-283382-t890r7xp	87	29	,	,	,
cord-283382-t890r7xp	87	30	including	include	VBG
cord-283382-t890r7xp	87	31	viruses	virus	NNS
cord-283382-t890r7xp	87	32	(	(	-LRB-
cord-283382-t890r7xp	87	33	75	75	CD
cord-283382-t890r7xp	87	34	)	)	-RRB-
cord-283382-t890r7xp	87	35	.	.	.
cord-283382-t890r7xp	88	1	In	in	IN
cord-283382-t890r7xp	88	2	addition	addition	NN
cord-283382-t890r7xp	88	3	to	to	IN
cord-283382-t890r7xp	88	4	contributing	contribute	VBG
cord-283382-t890r7xp	88	5	to	to	IN
cord-283382-t890r7xp	88	6	the	the	DT
cord-283382-t890r7xp	88	7	clearance	clearance	NN
cord-283382-t890r7xp	88	8	of	of	IN
cord-283382-t890r7xp	88	9	particulate	particulate	NN
cord-283382-t890r7xp	88	10	Ag	Ag	NNP
cord-283382-t890r7xp	88	11	,	,	,
cord-283382-t890r7xp	88	12	scavenging	scavenging	NN
cord-283382-t890r7xp	88	13	receptors	receptor	NNS
cord-283382-t890r7xp	88	14	have	have	VBP
cord-283382-t890r7xp	88	15	been	be	VBN
cord-283382-t890r7xp	88	16	implicated	implicate	VBN
cord-283382-t890r7xp	88	17	in	in	IN
cord-283382-t890r7xp	88	18	innate	innate	JJ
cord-283382-t890r7xp	88	19	immune	immune	JJ
cord-283382-t890r7xp	88	20	sensing	sensing	NN
cord-283382-t890r7xp	88	21	,	,	,
cord-283382-t890r7xp	88	22	due	due	IN
cord-283382-t890r7xp	88	23	to	to	IN
cord-283382-t890r7xp	88	24	their	-PRON-	PRP$
cord-283382-t890r7xp	88	25	ability	ability	NN
cord-283382-t890r7xp	88	26	to	to	TO
cord-283382-t890r7xp	88	27	recognize	recognize	VB
cord-283382-t890r7xp	88	28	pathogen	pathogen	NN
cord-283382-t890r7xp	88	29	-	-	HYPH
cord-283382-t890r7xp	88	30	associated	associate	VBN
cord-283382-t890r7xp	88	31	molecular	molecular	JJ
cord-283382-t890r7xp	88	32	patterns	pattern	NNS
cord-283382-t890r7xp	88	33	(	(	-LRB-
cord-283382-t890r7xp	88	34	PAMPs	pamp	NNS
cord-283382-t890r7xp	88	35	)	)	-RRB-
cord-283382-t890r7xp	88	36	.	.	.
cord-283382-t890r7xp	89	1	Murine	Murine	NNP
cord-283382-t890r7xp	89	2	SR	SR	NNP
cord-283382-t890r7xp	89	3	-	-	HYPH
cord-283382-t890r7xp	89	4	A1	A1	NNP
cord-283382-t890r7xp	89	5	(	(	-LRB-
cord-283382-t890r7xp	89	6	74	74	CD
cord-283382-t890r7xp	89	7	)	)	-RRB-
cord-283382-t890r7xp	89	8	,	,	,
cord-283382-t890r7xp	89	9	SR	SR	NNP
cord-283382-t890r7xp	89	10	-	-	HYPH
cord-283382-t890r7xp	89	11	AII	AII	NNP
cord-283382-t890r7xp	89	12	(	(	-LRB-
cord-283382-t890r7xp	89	13	76	76	CD
cord-283382-t890r7xp	89	14	)	)	-RRB-
cord-283382-t890r7xp	89	15	,	,	,
cord-283382-t890r7xp	89	16	and	and	CC
cord-283382-t890r7xp	89	17	MARCO	MARCO	NNP
cord-283382-t890r7xp	89	18	(	(	-LRB-
cord-283382-t890r7xp	89	19	SR	SR	NNP
cord-283382-t890r7xp	89	20	-	-	HYPH
cord-283382-t890r7xp	89	21	A6	A6	NNP
cord-283382-t890r7xp	89	22	)	)	-RRB-
cord-283382-t890r7xp	89	23	(	(	-LRB-
cord-283382-t890r7xp	89	24	67	67	CD
cord-283382-t890r7xp	89	25	)	)	-RRB-
cord-283382-t890r7xp	89	26	have	have	VBP
cord-283382-t890r7xp	89	27	been	be	VBN
cord-283382-t890r7xp	89	28	described	describe	VBN
cord-283382-t890r7xp	89	29	as	as	IN
cord-283382-t890r7xp	89	30	receptors	receptor	NNS
cord-283382-t890r7xp	89	31	for	for	IN
cord-283382-t890r7xp	89	32	rAd	rAd	NNP
cord-283382-t890r7xp	89	33	vectors	vector	NNS
cord-283382-t890r7xp	89	34	,	,	,
cord-283382-t890r7xp	89	35	and	and	CC
cord-283382-t890r7xp	89	36	MARCO	MARCO	NNP
cord-283382-t890r7xp	89	37	+	+	CC
cord-283382-t890r7xp	89	38	marginal	marginal	JJ
cord-283382-t890r7xp	89	39	zone	zone	NN
cord-283382-t890r7xp	89	40	macrophages	macrophage	NNS
cord-283382-t890r7xp	89	41	in	in	IN
cord-283382-t890r7xp	89	42	the	the	DT
cord-283382-t890r7xp	89	43	spleen	spleen	NN
cord-283382-t890r7xp	89	44	have	have	VBP
cord-283382-t890r7xp	89	45	been	be	VBN
cord-283382-t890r7xp	89	46	shown	show	VBN
cord-283382-t890r7xp	89	47	to	to	TO
cord-283382-t890r7xp	89	48	accumulate	accumulate	VB
cord-283382-t890r7xp	89	49	Ad5-based	ad5-based	JJ
cord-283382-t890r7xp	89	50	vectors	vector	NNS
cord-283382-t890r7xp	89	51	following	follow	VBG
cord-283382-t890r7xp	89	52	intravenous	intravenous	JJ
cord-283382-t890r7xp	89	53	(	(	-LRB-
cord-283382-t890r7xp	89	54	i.v	i.v	NNP
cord-283382-t890r7xp	89	55	.	.	NNP
cord-283382-t890r7xp	89	56	)	)	-RRB-
cord-283382-t890r7xp	89	57	delivery	delivery	NN
cord-283382-t890r7xp	89	58	in	in	IN
cord-283382-t890r7xp	89	59	mice	mouse	NNS
cord-283382-t890r7xp	89	60	(	(	-LRB-
cord-283382-t890r7xp	89	61	28	28	CD
cord-283382-t890r7xp	89	62	,	,	,
cord-283382-t890r7xp	89	63	77	77	CD
cord-283382-t890r7xp	89	64	)	)	-RRB-
cord-283382-t890r7xp	89	65	.	.	.
cord-283382-t890r7xp	90	1	The	the	DT
cord-283382-t890r7xp	90	2	fiber	fiber	NN
cord-283382-t890r7xp	90	3	knob	knob	NN
cord-283382-t890r7xp	90	4	(	(	-LRB-
cord-283382-t890r7xp	90	5	i.e.	i.e.	FW
cord-283382-t890r7xp	90	6	,	,	,
cord-283382-t890r7xp	90	7	SR	SR	NNP
cord-283382-t890r7xp	90	8	-	-	HYPH
cord-283382-t890r7xp	90	9	A1	A1	NNP
cord-283382-t890r7xp	90	10	)	)	-RRB-
cord-283382-t890r7xp	90	11	,	,	,
cord-283382-t890r7xp	90	12	or	or	CC
cord-283382-t890r7xp	90	13	hexon	hexon	NNP
cord-283382-t890r7xp	90	14	protein	protein	NN
cord-283382-t890r7xp	90	15	has	have	VBZ
cord-283382-t890r7xp	90	16	been	be	VBN
cord-283382-t890r7xp	90	17	implicated	implicate	VBN
cord-283382-t890r7xp	90	18	in	in	IN
cord-283382-t890r7xp	90	19	mediating	mediate	VBG
cord-283382-t890r7xp	90	20	these	these	DT
cord-283382-t890r7xp	90	21	interactions	interaction	NNS
cord-283382-t890r7xp	90	22	(	(	-LRB-
cord-283382-t890r7xp	90	23	i.e.	i.e.	FW
cord-283382-t890r7xp	90	24	,	,	,
cord-283382-t890r7xp	90	25	SR	SR	NNP
cord-283382-t890r7xp	90	26	-	-	HYPH
cord-283382-t890r7xp	90	27	AII	AII	NNP
cord-283382-t890r7xp	90	28	and	and	CC
cord-283382-t890r7xp	90	29	SR	SR	NNP
cord-283382-t890r7xp	90	30	-	-	HYPH
cord-283382-t890r7xp	90	31	A6	A6	NNP
cord-283382-t890r7xp	90	32	)	)	-RRB-
cord-283382-t890r7xp	90	33	.	.	.
cord-283382-t890r7xp	91	1	Interestingly	interestingly	RB
cord-283382-t890r7xp	91	2	,	,	,
cord-283382-t890r7xp	91	3	SR	SR	NNP
cord-283382-t890r7xp	91	4	-	-	HYPH
cord-283382-t890r7xp	91	5	A6	A6	NNP
cord-283382-t890r7xp	91	6	(	(	-LRB-
cord-283382-t890r7xp	91	7	MARCO	MARCO	NNP
cord-283382-t890r7xp	91	8	)	)	-RRB-
cord-283382-t890r7xp	91	9	was	be	VBD
cord-283382-t890r7xp	91	10	shown	show	VBN
cord-283382-t890r7xp	91	11	to	to	IN
cord-283382-t890r7xp	91	12	not	not	RB
cord-283382-t890r7xp	91	13	only	only	RB
cord-283382-t890r7xp	91	14	facilitate	facilitate	VB
cord-283382-t890r7xp	91	15	entry	entry	NN
cord-283382-t890r7xp	91	16	and	and	CC
cord-283382-t890r7xp	91	17	efficient	efficient	JJ
cord-283382-t890r7xp	91	18	gene	gene	NN
cord-283382-t890r7xp	91	19	transduction	transduction	NN
cord-283382-t890r7xp	91	20	with	with	IN
cord-283382-t890r7xp	91	21	Ad5	ad5	CD
cord-283382-t890r7xp	91	22	,	,	,
cord-283382-t890r7xp	91	23	but	but	CC
cord-283382-t890r7xp	91	24	also	also	RB
cord-283382-t890r7xp	91	25	with	with	IN
cord-283382-t890r7xp	91	26	HAdV	HAdV	NNP
cord-283382-t890r7xp	91	27	-	-	HYPH
cord-283382-t890r7xp	91	28	C2	C2	NNP
cord-283382-t890r7xp	91	29	,	,	,
cord-283382-t890r7xp	91	30	HAdV	HAdV	NNP
cord-283382-t890r7xp	91	31	-	-	HYPH
cord-283382-t890r7xp	91	32	B35	B35	NNP
cord-283382-t890r7xp	91	33	,	,	,
cord-283382-t890r7xp	91	34	and	and	CC
cord-283382-t890r7xp	91	35	HAdV	HAdV	NNP
cord-283382-t890r7xp	91	36	-	-	HYPH
cord-283382-t890r7xp	91	37	D26	D26	NNP
cord-283382-t890r7xp	91	38	(	(	-LRB-
cord-283382-t890r7xp	91	39	67	67	CD
cord-283382-t890r7xp	91	40	)	)	-RRB-
cord-283382-t890r7xp	91	41	.	.	.
cord-283382-t890r7xp	92	1	The	the	DT
cord-283382-t890r7xp	92	2	mechanism	mechanism	NN
cord-283382-t890r7xp	92	3	of	of	IN
cord-283382-t890r7xp	92	4	interaction	interaction	NN
cord-283382-t890r7xp	92	5	between	between	IN
cord-283382-t890r7xp	92	6	Ad	ad	NN
cord-283382-t890r7xp	92	7	and	and	CC
cord-283382-t890r7xp	92	8	SR	SR	NNP
cord-283382-t890r7xp	92	9	-	-	HYPH
cord-283382-t890r7xp	92	10	AII	AII	NNP
cord-283382-t890r7xp	92	11	/	/	SYM
cord-283382-t890r7xp	92	12	SR	SR	NNP
cord-283382-t890r7xp	92	13	-	-	HYPH
cord-283382-t890r7xp	92	14	A6	A6	NNP
cord-283382-t890r7xp	92	15	was	be	VBD
cord-283382-t890r7xp	92	16	proposed	propose	VBN
cord-283382-t890r7xp	92	17	to	to	TO
cord-283382-t890r7xp	92	18	involve	involve	VB
cord-283382-t890r7xp	92	19	the	the	DT
cord-283382-t890r7xp	92	20	negative	negative	JJ
cord-283382-t890r7xp	92	21	charge	charge	NN
cord-283382-t890r7xp	92	22	conferred	confer	VBN
cord-283382-t890r7xp	92	23	by	by	IN
cord-283382-t890r7xp	92	24	specific	specific	JJ
cord-283382-t890r7xp	92	25	hypervariable	hypervariable	JJ
cord-283382-t890r7xp	92	26	regions	region	NNS
cord-283382-t890r7xp	92	27	(	(	-LRB-
cord-283382-t890r7xp	92	28	HVRs	HVRs	NNP
cord-283382-t890r7xp	92	29	)	)	-RRB-
cord-283382-t890r7xp	92	30	of	of	IN
cord-283382-t890r7xp	92	31	the	the	DT
cord-283382-t890r7xp	92	32	viral	viral	JJ
cord-283382-t890r7xp	92	33	hexon	hexon	NN
cord-283382-t890r7xp	92	34	,	,	,
cord-283382-t890r7xp	92	35	namely	namely	RB
cord-283382-t890r7xp	92	36	HVR1	HVR1	NNP
cord-283382-t890r7xp	92	37	.	.	.
cord-283382-t890r7xp	93	1	In	in	IN
cord-283382-t890r7xp	93	2	support	support	NN
cord-283382-t890r7xp	93	3	of	of	IN
cord-283382-t890r7xp	93	4	this	this	DT
cord-283382-t890r7xp	93	5	,	,	,
cord-283382-t890r7xp	93	6	preferential	preferential	JJ
cord-283382-t890r7xp	93	7	scavenging	scavenging	NN
cord-283382-t890r7xp	93	8	of	of	IN
cord-283382-t890r7xp	93	9	negatively	negatively	RB
cord-283382-t890r7xp	93	10	charged	charge	VBN
cord-283382-t890r7xp	93	11	particles	particle	NNS
cord-283382-t890r7xp	93	12	has	have	VBZ
cord-283382-t890r7xp	93	13	previously	previously	RB
cord-283382-t890r7xp	93	14	been	be	VBN
cord-283382-t890r7xp	93	15	shown	show	VBN
cord-283382-t890r7xp	93	16	to	to	TO
cord-283382-t890r7xp	93	17	contribute	contribute	VB
cord-283382-t890r7xp	93	18	to	to	IN
cord-283382-t890r7xp	93	19	the	the	DT
cord-283382-t890r7xp	93	20	differential	differential	JJ
cord-283382-t890r7xp	93	21	recognition	recognition	NN
cord-283382-t890r7xp	93	22	of	of	IN
cord-283382-t890r7xp	93	23	Ad	ad	NN
cord-283382-t890r7xp	93	24	vectors	vector	NNS
cord-283382-t890r7xp	93	25	by	by	IN
cord-283382-t890r7xp	93	26	macrophages	macrophage	NNS
cord-283382-t890r7xp	93	27	in	in	IN
cord-283382-t890r7xp	93	28	vivo	vivo	NNP
cord-283382-t890r7xp	93	29	(	(	-LRB-
cord-283382-t890r7xp	93	30	76	76	CD
cord-283382-t890r7xp	93	31	,	,	,
cord-283382-t890r7xp	93	32	78	78	CD
cord-283382-t890r7xp	93	33	,	,	,
cord-283382-t890r7xp	93	34	79	79	CD
cord-283382-t890r7xp	93	35	)	)	-RRB-
cord-283382-t890r7xp	93	36	.	.	.
cord-283382-t890r7xp	94	1	Dendritic	dendritic	JJ
cord-283382-t890r7xp	94	2	cells	cell	NNS
cord-283382-t890r7xp	94	3	.	.	.
cord-283382-t890r7xp	95	1	Dendritic	dendritic	JJ
cord-283382-t890r7xp	95	2	cells	cell	NNS
cord-283382-t890r7xp	95	3	(	(	-LRB-
cord-283382-t890r7xp	95	4	DCs	DCs	NNP
cord-283382-t890r7xp	95	5	)	)	-RRB-
cord-283382-t890r7xp	95	6	are	be	VBP
cord-283382-t890r7xp	95	7	a	a	DT
cord-283382-t890r7xp	95	8	specialized	specialized	JJ
cord-283382-t890r7xp	95	9	subset	subset	NN
cord-283382-t890r7xp	95	10	of	of	IN
cord-283382-t890r7xp	95	11	professional	professional	JJ
cord-283382-t890r7xp	95	12	Ag	Ag	NNP
cord-283382-t890r7xp	95	13	presenting	present	VBG
cord-283382-t890r7xp	95	14	cells	cell	NNS
cord-283382-t890r7xp	95	15	which	which	WDT
cord-283382-t890r7xp	95	16	are	be	VBP
cord-283382-t890r7xp	95	17	central	central	JJ
cord-283382-t890r7xp	95	18	to	to	IN
cord-283382-t890r7xp	95	19	the	the	DT
cord-283382-t890r7xp	95	20	development	development	NN
cord-283382-t890r7xp	95	21	of	of	IN
cord-283382-t890r7xp	95	22	protective	protective	JJ
cord-283382-t890r7xp	95	23	immunity	immunity	NN
cord-283382-t890r7xp	95	24	.	.	.
cord-283382-t890r7xp	96	1	DCs	DCs	NNP
cord-283382-t890r7xp	96	2	can	can	MD
cord-283382-t890r7xp	96	3	process	process	VB
cord-283382-t890r7xp	96	4	Ag	Ag	NNP
cord-283382-t890r7xp	96	5	using	use	VBG
cord-283382-t890r7xp	96	6	several	several	JJ
cord-283382-t890r7xp	96	7	methods	method	NNS
cord-283382-t890r7xp	96	8	;	;	,
cord-283382-t890r7xp	96	9	(	(	-LRB-
cord-283382-t890r7xp	96	10	i	i	NN
cord-283382-t890r7xp	96	11	)	)	-RRB-
cord-283382-t890r7xp	96	12	direct	direct	JJ
cord-283382-t890r7xp	96	13	presentation	presentation	NN
cord-283382-t890r7xp	96	14	,	,	,
cord-283382-t890r7xp	96	15	in	in	IN
cord-283382-t890r7xp	96	16	which	which	WDT
cord-283382-t890r7xp	96	17	an	an	DT
cord-283382-t890r7xp	96	18	infected	infected	JJ
cord-283382-t890r7xp	96	19	DC	DC	NNP
cord-283382-t890r7xp	96	20	presents	present	VBZ
cord-283382-t890r7xp	96	21	peptide	peptide	NN
cord-283382-t890r7xp	96	22	:	:	:
cord-283382-t890r7xp	96	23	major	major	JJ
cord-283382-t890r7xp	96	24	histocompatibility	histocompatibility	NN
cord-283382-t890r7xp	96	25	complex	complex	JJ
cord-283382-t890r7xp	96	26	class	class	NN
cord-283382-t890r7xp	96	27	(	(	-LRB-
cord-283382-t890r7xp	96	28	MHC	MHC	NNP
cord-283382-t890r7xp	96	29	)	)	-RRB-
cord-283382-t890r7xp	96	30	complexes	complex	NNS
cord-283382-t890r7xp	96	31	directly	directly	RB
cord-283382-t890r7xp	96	32	to	to	IN
cord-283382-t890r7xp	96	33	T	t	NN
cord-283382-t890r7xp	96	34	cells	cell	NNS
cord-283382-t890r7xp	96	35	,	,	,
cord-283382-t890r7xp	96	36	(	(	-LRB-
cord-283382-t890r7xp	96	37	ii	ii	NN
cord-283382-t890r7xp	96	38	)	)	-RRB-
cord-283382-t890r7xp	96	39	cross	cross	JJ
cord-283382-t890r7xp	96	40	-	-	NN
cord-283382-t890r7xp	96	41	presentation	presentation	NN
cord-283382-t890r7xp	96	42	in	in	IN
cord-283382-t890r7xp	96	43	which	which	WDT
cord-283382-t890r7xp	96	44	Ag	Ag	NNP
cord-283382-t890r7xp	96	45	derived	derive	VBD
cord-283382-t890r7xp	96	46	from	from	IN
cord-283382-t890r7xp	96	47	other	other	JJ
cord-283382-t890r7xp	96	48	infected	infected	JJ
cord-283382-t890r7xp	96	49	cells	cell	NNS
cord-283382-t890r7xp	96	50	is	be	VBZ
cord-283382-t890r7xp	96	51	phagocytosed	phagocytose	VBN
cord-283382-t890r7xp	96	52	by	by	IN
cord-283382-t890r7xp	96	53	DCs	DCs	NNP
cord-283382-t890r7xp	96	54	,	,	,
cord-283382-t890r7xp	96	55	processed	process	VBN
cord-283382-t890r7xp	96	56	and	and	CC
cord-283382-t890r7xp	96	57	then	then	RB
cord-283382-t890r7xp	96	58	presented	present	VBN
cord-283382-t890r7xp	96	59	to	to	IN
cord-283382-t890r7xp	96	60	T	T	NNP
cord-283382-t890r7xp	96	61	cells	cell	NNS
cord-283382-t890r7xp	96	62	,	,	,
cord-283382-t890r7xp	96	63	and	and	CC
cord-283382-t890r7xp	96	64	(	(	-LRB-
cord-283382-t890r7xp	96	65	iii	iii	NN
cord-283382-t890r7xp	96	66	)	)	-RRB-
cord-283382-t890r7xp	96	67	cross	cross	NN
cord-283382-t890r7xp	96	68	-	-	JJ
cord-283382-t890r7xp	96	69	dressing	dressing	JJ
cord-283382-t890r7xp	96	70	(	(	-LRB-
cord-283382-t890r7xp	96	71	80	80	CD
cord-283382-t890r7xp	96	72	)	)	-RRB-
cord-283382-t890r7xp	96	73	,	,	,
cord-283382-t890r7xp	96	74	in	in	IN
cord-283382-t890r7xp	96	75	which	which	WDT
cord-283382-t890r7xp	96	76	peptide	peptide	NN
cord-283382-t890r7xp	96	77	:	:	:
cord-283382-t890r7xp	97	1	MHC	MHC	NNP
cord-283382-t890r7xp	97	2	complexes	complex	NNS
cord-283382-t890r7xp	97	3	are	be	VBP
cord-283382-t890r7xp	97	4	acquired	acquire	VBN
cord-283382-t890r7xp	97	5	from	from	IN
cord-283382-t890r7xp	97	6	other	other	JJ
cord-283382-t890r7xp	97	7	professional	professional	JJ
cord-283382-t890r7xp	97	8	or	or	CC
cord-283382-t890r7xp	97	9	non	non	JJ
cord-283382-t890r7xp	97	10	-	-	JJ
cord-283382-t890r7xp	97	11	professional	professional	JJ
cord-283382-t890r7xp	97	12	antigen	antigen	NN
cord-283382-t890r7xp	97	13	presenting	present	VBG
cord-283382-t890r7xp	97	14	cells	cell	NNS
cord-283382-t890r7xp	97	15	(	(	-LRB-
cord-283382-t890r7xp	97	16	APCs	apc	NNS
cord-283382-t890r7xp	97	17	)	)	-RRB-
cord-283382-t890r7xp	97	18	and	and	CC
cord-283382-t890r7xp	97	19	are	be	VBP
cord-283382-t890r7xp	97	20	transferred	transfer	VBN
cord-283382-t890r7xp	97	21	to	to	IN
cord-283382-t890r7xp	97	22	the	the	DT
cord-283382-t890r7xp	97	23	DC	DC	NNP
cord-283382-t890r7xp	97	24	through	through	IN
cord-283382-t890r7xp	97	25	a	a	DT
cord-283382-t890r7xp	97	26	process	process	NN
cord-283382-t890r7xp	97	27	of	of	IN
cord-283382-t890r7xp	97	28	trogocytosis	trogocytosis	NN
cord-283382-t890r7xp	97	29	,	,	,
cord-283382-t890r7xp	97	30	in	in	IN
cord-283382-t890r7xp	97	31	which	which	WDT
cord-283382-t890r7xp	97	32	fragments	fragment	NNS
cord-283382-t890r7xp	97	33	of	of	IN
cord-283382-t890r7xp	97	34	the	the	DT
cord-283382-t890r7xp	97	35	plasma	plasma	NN
cord-283382-t890r7xp	97	36	membrane	membrane	NN
cord-283382-t890r7xp	97	37	containing	contain	VBG
cord-283382-t890r7xp	97	38	the	the	DT
cord-283382-t890r7xp	97	39	MHC	MHC	NNP
cord-283382-t890r7xp	97	40	complex	complex	NN
cord-283382-t890r7xp	97	41	merges	merge	VBZ
cord-283382-t890r7xp	97	42	with	with	IN
cord-283382-t890r7xp	97	43	the	the	DT
cord-283382-t890r7xp	97	44	recipient	recipient	NN
cord-283382-t890r7xp	97	45	cell	cell	NN
cord-283382-t890r7xp	97	46	.	.	.
cord-283382-t890r7xp	98	1	Cross	cross	NN
cord-283382-t890r7xp	98	2	-	-	NN
cord-283382-t890r7xp	98	3	dressing	dressing	NN
cord-283382-t890r7xp	98	4	is	be	VBZ
cord-283382-t890r7xp	98	5	also	also	RB
cord-283382-t890r7xp	98	6	hypothesized	hypothesize	VBN
cord-283382-t890r7xp	98	7	to	to	TO
cord-283382-t890r7xp	98	8	occur	occur	VB
cord-283382-t890r7xp	98	9	through	through	IN
cord-283382-t890r7xp	98	10	the	the	DT
cord-283382-t890r7xp	98	11	intercellular	intercellular	JJ
cord-283382-t890r7xp	98	12	transfer	transfer	NN
cord-283382-t890r7xp	98	13	of	of	IN
cord-283382-t890r7xp	98	14	pre	pre	JJ
cord-283382-t890r7xp	98	15	-	-	JJ
cord-283382-t890r7xp	98	16	formed	form	VBN
cord-283382-t890r7xp	98	17	peptide	peptide	NN
cord-283382-t890r7xp	98	18	:	:	:
cord-283382-t890r7xp	99	1	MHC	MHC	NNP
cord-283382-t890r7xp	99	2	complexes	complex	NNS
cord-283382-t890r7xp	99	3	by	by	IN
cord-283382-t890r7xp	99	4	extracellular	extracellular	JJ
cord-283382-t890r7xp	99	5	vesicles	vesicle	NNS
cord-283382-t890r7xp	99	6	,	,	,
cord-283382-t890r7xp	99	7	such	such	JJ
cord-283382-t890r7xp	99	8	as	as	IN
cord-283382-t890r7xp	99	9	exosomes	exosomes	NNP
cord-283382-t890r7xp	99	10	[	[	-LRB-
cord-283382-t890r7xp	99	11	(	(	-LRB-
cord-283382-t890r7xp	99	12	81	81	CD
cord-283382-t890r7xp	99	13	-	-	SYM
cord-283382-t890r7xp	99	14	84	84	CD
cord-283382-t890r7xp	99	15	)	)	-RRB-
cord-283382-t890r7xp	99	16	;	;	:
cord-283382-t890r7xp	99	17	Figure	figure	NN
cord-283382-t890r7xp	99	18	3	3	CD
cord-283382-t890r7xp	99	19	]	]	-RRB-
cord-283382-t890r7xp	99	20	.	.	.
cord-283382-t890r7xp	100	1	A	a	DT
cord-283382-t890r7xp	100	2	critical	critical	JJ
cord-283382-t890r7xp	100	3	role	role	NN
cord-283382-t890r7xp	100	4	for	for	IN
cord-283382-t890r7xp	100	5	DCs	dc	NNS
cord-283382-t890r7xp	100	6	in	in	IN
cord-283382-t890r7xp	100	7	the	the	DT
cord-283382-t890r7xp	100	8	robust	robust	JJ
cord-283382-t890r7xp	100	9	induction	induction	NN
cord-283382-t890r7xp	100	10	of	of	IN
cord-283382-t890r7xp	100	11	CD8	CD8	NNP
cord-283382-t890r7xp	100	12	+	+	CC
cord-283382-t890r7xp	100	13	T	T	NNP
cord-283382-t890r7xp	100	14	cell	cell	NN
cord-283382-t890r7xp	100	15	responses	response	NNS
cord-283382-t890r7xp	100	16	following	follow	VBG
cord-283382-t890r7xp	100	17	immunization	immunization	NN
cord-283382-t890r7xp	100	18	with	with	IN
cord-283382-t890r7xp	100	19	rAd	rAd	NNP
cord-283382-t890r7xp	100	20	vectors	vector	NNS
cord-283382-t890r7xp	100	21	has	have	VBZ
cord-283382-t890r7xp	100	22	been	be	VBN
cord-283382-t890r7xp	100	23	demonstrated	demonstrate	VBN
cord-283382-t890r7xp	100	24	(	(	-LRB-
cord-283382-t890r7xp	100	25	86	86	CD
cord-283382-t890r7xp	100	26	,	,	,
cord-283382-t890r7xp	100	27	87	87	CD
cord-283382-t890r7xp	100	28	)	)	-RRB-
cord-283382-t890r7xp	100	29	.	.	.
cord-283382-t890r7xp	101	1	It	-PRON-	PRP
cord-283382-t890r7xp	101	2	has	have	VBZ
cord-283382-t890r7xp	101	3	been	be	VBN
cord-283382-t890r7xp	101	4	shown	show	VBN
cord-283382-t890r7xp	101	5	that	that	IN
cord-283382-t890r7xp	101	6	CD8	CD8	NNP
cord-283382-t890r7xp	101	7	+	+	XX
cord-283382-t890r7xp	101	8	,	,	,
cord-283382-t890r7xp	101	9	but	but	CC
cord-283382-t890r7xp	101	10	not	not	RB
cord-283382-t890r7xp	101	11	CD4	CD4	NNP
cord-283382-t890r7xp	101	12	+	+	CC
cord-283382-t890r7xp	101	13	T	t	NN
cord-283382-t890r7xp	101	14	cell	cell	NN
cord-283382-t890r7xp	101	15	responses	response	NNS
cord-283382-t890r7xp	101	16	elicited	elicit	VBN
cord-283382-t890r7xp	101	17	by	by	IN
cord-283382-t890r7xp	101	18	Ad	ad	NN
cord-283382-t890r7xp	101	19	vaccines	vaccine	NNS
cord-283382-t890r7xp	101	20	,	,	,
cord-283382-t890r7xp	101	21	are	be	VBP
cord-283382-t890r7xp	101	22	dependent	dependent	JJ
cord-283382-t890r7xp	101	23	on	on	IN
cord-283382-t890r7xp	101	24	cross	cross	NN
cord-283382-t890r7xp	101	25	-	-	NN
cord-283382-t890r7xp	101	26	presentation	presentation	NN
cord-283382-t890r7xp	101	27	by	by	IN
cord-283382-t890r7xp	101	28	specific	specific	JJ
cord-283382-t890r7xp	101	29	sub	sub	NN
cord-283382-t890r7xp	101	30	-	-	NNS
cord-283382-t890r7xp	101	31	populations	population	NNS
cord-283382-t890r7xp	101	32	of	of	IN
cord-283382-t890r7xp	101	33	DCs	dc	NNS
cord-283382-t890r7xp	101	34	,	,	,
cord-283382-t890r7xp	101	35	including	include	VBG
cord-283382-t890r7xp	101	36	CD8α	CD8α	NNP
cord-283382-t890r7xp	101	37	+	+	CC
cord-283382-t890r7xp	101	38	DCs	DCs	NNP
cord-283382-t890r7xp	101	39	(	(	-LRB-
cord-283382-t890r7xp	101	40	33	33	CD
cord-283382-t890r7xp	101	41	)	)	-RRB-
cord-283382-t890r7xp	101	42	.	.	.
cord-283382-t890r7xp	102	1	In	in	IN
cord-283382-t890r7xp	102	2	support	support	NN
cord-283382-t890r7xp	102	3	of	of	IN
cord-283382-t890r7xp	102	4	this	this	DT
cord-283382-t890r7xp	102	5	,	,	,
cord-283382-t890r7xp	102	6	Ag	Ag	NNP
cord-283382-t890r7xp	102	7	-	-	HYPH
cord-283382-t890r7xp	102	8	specific	specific	JJ
cord-283382-t890r7xp	102	9	CD8	CD8	NNP
cord-283382-t890r7xp	102	10	+	+	CC
cord-283382-t890r7xp	102	11	T	t	NN
cord-283382-t890r7xp	102	12	cell	cell	NN
cord-283382-t890r7xp	102	13	responses	response	NNS
cord-283382-t890r7xp	102	14	in	in	IN
cord-283382-t890r7xp	102	15	BATF3-deficient	BATF3-deficient	NNP
cord-283382-t890r7xp	102	16	mice	mouse	NNS
cord-283382-t890r7xp	102	17	(	(	-LRB-
cord-283382-t890r7xp	102	18	Batf3	Batf3	NNP
cord-283382-t890r7xp	102	19	−/−	−/−	NNP
cord-283382-t890r7xp	102	20	)	)	-RRB-
cord-283382-t890r7xp	102	21	,	,	,
cord-283382-t890r7xp	102	22	which	which	WDT
cord-283382-t890r7xp	102	23	preclude	preclude	VBP
cord-283382-t890r7xp	102	24	the	the	DT
cord-283382-t890r7xp	102	25	development	development	NN
cord-283382-t890r7xp	102	26	of	of	IN
cord-283382-t890r7xp	102	27	the	the	DT
cord-283382-t890r7xp	102	28	latter	latter	JJ
cord-283382-t890r7xp	102	29	DC	DC	NNP
cord-283382-t890r7xp	102	30	population	population	NN
cord-283382-t890r7xp	102	31	(	(	-LRB-
cord-283382-t890r7xp	102	32	CD8α	CD8α	NNP
cord-283382-t890r7xp	102	33	+	+	CC
cord-283382-t890r7xp	102	34	DCs	DCs	NNP
cord-283382-t890r7xp	102	35	)	)	-RRB-
cord-283382-t890r7xp	102	36	,	,	,
cord-283382-t890r7xp	102	37	were	be	VBD
cord-283382-t890r7xp	102	38	shown	show	VBN
cord-283382-t890r7xp	102	39	to	to	TO
cord-283382-t890r7xp	102	40	be	be	VB
cord-283382-t890r7xp	102	41	∼80	∼80	TO
cord-283382-t890r7xp	102	42	%	%	NN
cord-283382-t890r7xp	102	43	lower	low	JJR
cord-283382-t890r7xp	102	44	following	follow	VBG
cord-283382-t890r7xp	102	45	immunization	immunization	NN
cord-283382-t890r7xp	102	46	with	with	IN
cord-283382-t890r7xp	102	47	several	several	JJ
cord-283382-t890r7xp	102	48	Ad	ad	NN
cord-283382-t890r7xp	102	49	vectors	vector	NNS
cord-283382-t890r7xp	102	50	(	(	-LRB-
cord-283382-t890r7xp	102	51	33	33	CD
cord-283382-t890r7xp	102	52	)	)	-RRB-
cord-283382-t890r7xp	102	53	.	.	.
cord-283382-t890r7xp	103	1	DCs	DCs	NNP
cord-283382-t890r7xp	103	2	infected	infect	VBN
cord-283382-t890r7xp	103	3	with	with	IN
cord-283382-t890r7xp	103	4	Ads	ad	NNS
cord-283382-t890r7xp	103	5	upregulate	upregulate	VB
cord-283382-t890r7xp	103	6	MHC	MHC	NNP
cord-283382-t890r7xp	103	7	,	,	,
cord-283382-t890r7xp	103	8	as	as	RB
cord-283382-t890r7xp	103	9	well	well	RB
cord-283382-t890r7xp	103	10	as	as	IN
cord-283382-t890r7xp	103	11	co	co	JJ
cord-283382-t890r7xp	103	12	-	-	JJ
cord-283382-t890r7xp	103	13	stimulatory	stimulatory	JJ
cord-283382-t890r7xp	103	14	molecules	molecule	NNS
cord-283382-t890r7xp	103	15	including	include	VBG
cord-283382-t890r7xp	103	16	CD40	CD40	NNP
cord-283382-t890r7xp	103	17	,	,	,
cord-283382-t890r7xp	103	18	CD80	CD80	NNP
cord-283382-t890r7xp	103	19	,	,	,
cord-283382-t890r7xp	103	20	or	or	CC
cord-283382-t890r7xp	103	21	CD86	CD86	NNP
cord-283382-t890r7xp	103	22	,	,	,
cord-283382-t890r7xp	103	23	leading	lead	VBG
cord-283382-t890r7xp	103	24	to	to	IN
cord-283382-t890r7xp	103	25	the	the	DT
cord-283382-t890r7xp	103	26	activation	activation	NN
cord-283382-t890r7xp	103	27	or	or	CC
cord-283382-t890r7xp	103	28	maturation	maturation	NN
cord-283382-t890r7xp	103	29	of	of	IN
cord-283382-t890r7xp	103	30	DCs	DCs	NNP
cord-283382-t890r7xp	103	31	(	(	-LRB-
cord-283382-t890r7xp	103	32	88	88	CD
cord-283382-t890r7xp	103	33	)	)	-RRB-
cord-283382-t890r7xp	103	34	,	,	,
cord-283382-t890r7xp	103	35	in	in	IN
cord-283382-t890r7xp	103	36	a	a	DT
cord-283382-t890r7xp	103	37	manner	manner	NN
cord-283382-t890r7xp	103	38	which	which	WDT
cord-283382-t890r7xp	103	39	is	be	VBZ
cord-283382-t890r7xp	103	40	believed	believe	VBN
cord-283382-t890r7xp	103	41	to	to	TO
cord-283382-t890r7xp	103	42	be	be	VB
cord-283382-t890r7xp	103	43	dependent	dependent	JJ
cord-283382-t890r7xp	103	44	on	on	IN
cord-283382-t890r7xp	103	45	nuclear	nuclear	JJ
cord-283382-t890r7xp	103	46	factor	factor	NN
cord-283382-t890r7xp	103	47	kappa	kappa	NN
cord-283382-t890r7xp	103	48	-	-	HYPH
cord-283382-t890r7xp	103	49	lightchain	lightchain	NN
cord-283382-t890r7xp	103	50	-	-	HYPH
cord-283382-t890r7xp	103	51	enhancer	enhancer	NN
cord-283382-t890r7xp	103	52	of	of	IN
cord-283382-t890r7xp	103	53	activated	activate	VBN
cord-283382-t890r7xp	103	54	B	b	NN
cord-283382-t890r7xp	103	55	cells	cell	NNS
cord-283382-t890r7xp	103	56	(	(	-LRB-
cord-283382-t890r7xp	103	57	NF	nf	NN
cord-283382-t890r7xp	103	58	-	-	HYPH
cord-283382-t890r7xp	103	59	κB	κB	NNP
cord-283382-t890r7xp	103	60	)	)	-RRB-
cord-283382-t890r7xp	103	61	signaling	signal	VBG
cord-283382-t890r7xp	103	62	(	(	-LRB-
cord-283382-t890r7xp	103	63	89	89	CD
cord-283382-t890r7xp	103	64	)	)	-RRB-
cord-283382-t890r7xp	103	65	.	.	.
cord-283382-t890r7xp	104	1	The	the	DT
cord-283382-t890r7xp	104	2	maturation	maturation	NN
cord-283382-t890r7xp	104	3	of	of	IN
cord-283382-t890r7xp	104	4	murine	murine	JJ
cord-283382-t890r7xp	104	5	DCs	dc	NNS
cord-283382-t890r7xp	104	6	has	have	VBZ
cord-283382-t890r7xp	104	7	been	be	VBN
cord-283382-t890r7xp	104	8	proposed	propose	VBN
cord-283382-t890r7xp	104	9	to	to	TO
cord-283382-t890r7xp	104	10	be	be	VB
cord-283382-t890r7xp	104	11	mediated	mediate	VBN
cord-283382-t890r7xp	104	12	by	by	IN
cord-283382-t890r7xp	104	13	the	the	DT
cord-283382-t890r7xp	104	14	fiber	fiber	NN
cord-283382-t890r7xp	104	15	knob	knob	NN
cord-283382-t890r7xp	104	16	domain	domain	NN
cord-283382-t890r7xp	104	17	of	of	IN
cord-283382-t890r7xp	104	18	Ad5	Ad5	NNP
cord-283382-t890r7xp	104	19	(	(	-LRB-
cord-283382-t890r7xp	104	20	90	90	CD
cord-283382-t890r7xp	104	21	)	)	-RRB-
cord-283382-t890r7xp	104	22	.	.	.
cord-283382-t890r7xp	105	1	In	in	IN
cord-283382-t890r7xp	105	2	vivo	vivo	NN
cord-283382-t890r7xp	105	3	experiments	experiment	NNS
cord-283382-t890r7xp	105	4	in	in	IN
cord-283382-t890r7xp	105	5	mice	mouse	NNS
cord-283382-t890r7xp	105	6	have	have	VBP
cord-283382-t890r7xp	105	7	shown	show	VBN
cord-283382-t890r7xp	105	8	that	that	IN
cord-283382-t890r7xp	105	9	uptake	uptake	NN
cord-283382-t890r7xp	105	10	of	of	IN
cord-283382-t890r7xp	105	11	rAd5-based	rad5-based	JJ
cord-283382-t890r7xp	105	12	vaccines	vaccine	NNS
cord-283382-t890r7xp	105	13	in	in	IN
cord-283382-t890r7xp	105	14	draining	drain	VBG
cord-283382-t890r7xp	105	15	lymph	lymph	NN
cord-283382-t890r7xp	105	16	nodes	node	NNS
cord-283382-t890r7xp	105	17	(	(	-LRB-
cord-283382-t890r7xp	105	18	dLNs	dlns	FW
cord-283382-t890r7xp	105	19	)	)	-RRB-
cord-283382-t890r7xp	105	20	following	follow	VBG
cord-283382-t890r7xp	105	21	intramuscular	intramuscular	JJ
cord-283382-t890r7xp	105	22	(	(	-LRB-
cord-283382-t890r7xp	105	23	i.m	i.m	NNP
cord-283382-t890r7xp	105	24	.	.	NNP
cord-283382-t890r7xp	105	25	)	)	-RRB-
cord-283382-t890r7xp	105	26	or	or	CC
cord-283382-t890r7xp	105	27	subcutaneous	subcutaneous	JJ
cord-283382-t890r7xp	106	1	(	(	-LRB-
cord-283382-t890r7xp	106	2	s.c	s.c	NNP
cord-283382-t890r7xp	106	3	.	.	NNP
cord-283382-t890r7xp	106	4	)	)	-RRB-
cord-283382-t890r7xp	106	5	vaccination	vaccination	NN
cord-283382-t890r7xp	106	6	is	be	VBZ
cord-283382-t890r7xp	106	7	highest	high	JJS
cord-283382-t890r7xp	106	8	in	in	IN
cord-283382-t890r7xp	106	9	CD11c	CD11c	NNP
cord-283382-t890r7xp	106	10	+	+	SYM
cord-283382-t890r7xp	106	11	CD8	CD8	NNP
cord-283382-t890r7xp	106	12	−	−	NNP
cord-283382-t890r7xp	106	13	B220	B220	NNP
cord-283382-t890r7xp	106	14	−	−	CD
cord-283382-t890r7xp	106	15	DCs	dc	NNS
cord-283382-t890r7xp	106	16	,	,	,
cord-283382-t890r7xp	106	17	although	although	IN
cord-283382-t890r7xp	106	18	CD11c	CD11c	NNP
cord-283382-t890r7xp	106	19	+	+	SYM
cord-283382-t890r7xp	106	20	CD8	CD8	NNP
cord-283382-t890r7xp	106	21	+	+	CC
cord-283382-t890r7xp	106	22	B220	B220	NNP
cord-283382-t890r7xp	106	23	−	−	NNP
cord-283382-t890r7xp	106	24	DCs	dc	NNS
cord-283382-t890r7xp	106	25	were	be	VBD
cord-283382-t890r7xp	106	26	the	the	DT
cord-283382-t890r7xp	106	27	most	most	RBS
cord-283382-t890r7xp	106	28	potent	potent	JJ
cord-283382-t890r7xp	106	29	for	for	IN
cord-283382-t890r7xp	106	30	eliciting	elicit	VBG
cord-283382-t890r7xp	106	31	naïve	naïve	JJ
cord-283382-t890r7xp	106	32	Ag	Ag	NNP
cord-283382-t890r7xp	106	33	-	-	HYPH
cord-283382-t890r7xp	106	34	specific	specific	JJ
cord-283382-t890r7xp	106	35	T	t	NN
cord-283382-t890r7xp	106	36	cell	cell	NN
cord-283382-t890r7xp	106	37	proliferation	proliferation	NN
cord-283382-t890r7xp	106	38	(	(	-LRB-
cord-283382-t890r7xp	106	39	86	86	CD
cord-283382-t890r7xp	106	40	)	)	-RRB-
cord-283382-t890r7xp	106	41	.	.	.
cord-283382-t890r7xp	107	1	As	as	IN
cord-283382-t890r7xp	107	2	previous	previous	JJ
cord-283382-t890r7xp	107	3	studies	study	NNS
cord-283382-t890r7xp	107	4	have	have	VBP
cord-283382-t890r7xp	107	5	shown	show	VBN
cord-283382-t890r7xp	107	6	that	that	IN
cord-283382-t890r7xp	107	7	targeting	target	VBG
cord-283382-t890r7xp	107	8	vaccine	vaccine	NN
cord-283382-t890r7xp	107	9	Ag	Ag	NNP
cord-283382-t890r7xp	107	10	to	to	TO
cord-283382-t890r7xp	107	11	defined	define	VBN
cord-283382-t890r7xp	107	12	populations	population	NNS
cord-283382-t890r7xp	107	13	of	of	IN
cord-283382-t890r7xp	107	14	DCs	dc	NNS
cord-283382-t890r7xp	107	15	can	can	MD
cord-283382-t890r7xp	107	16	improve	improve	VB
cord-283382-t890r7xp	107	17	immunity	immunity	NN
cord-283382-t890r7xp	107	18	and	and	CC
cord-283382-t890r7xp	107	19	vaccine	vaccine	NN
cord-283382-t890r7xp	107	20	efficacy	efficacy	NN
cord-283382-t890r7xp	107	21	(	(	-LRB-
cord-283382-t890r7xp	107	22	91	91	CD
cord-283382-t890r7xp	107	23	,	,	,
cord-283382-t890r7xp	107	24	92	92	CD
cord-283382-t890r7xp	107	25	)	)	-RRB-
cord-283382-t890r7xp	107	26	,	,	,
cord-283382-t890r7xp	107	27	efforts	effort	NNS
cord-283382-t890r7xp	107	28	are	be	VBP
cord-283382-t890r7xp	107	29	ongoing	ongoing	JJ
cord-283382-t890r7xp	107	30	to	to	TO
cord-283382-t890r7xp	107	31	better	better	RB
cord-283382-t890r7xp	107	32	understand	understand	VB
cord-283382-t890r7xp	107	33	the	the	DT
cord-283382-t890r7xp	107	34	precise	precise	JJ
cord-283382-t890r7xp	107	35	interactions	interaction	NNS
cord-283382-t890r7xp	107	36	between	between	IN
cord-283382-t890r7xp	107	37	diverse	diverse	JJ
cord-283382-t890r7xp	107	38	Ad	ad	NN
cord-283382-t890r7xp	107	39	types	type	NNS
cord-283382-t890r7xp	107	40	and	and	CC
cord-283382-t890r7xp	107	41	DC	DC	NNP
cord-283382-t890r7xp	107	42	subpopulations	subpopulation	NNS
cord-283382-t890r7xp	107	43	in	in	IN
cord-283382-t890r7xp	107	44	vivo	vivo	NN
cord-283382-t890r7xp	107	45	,	,	,
cord-283382-t890r7xp	107	46	as	as	RB
cord-283382-t890r7xp	107	47	well	well	RB
cord-283382-t890r7xp	107	48	as	as	IN
cord-283382-t890r7xp	107	49	how	how	WRB
cord-283382-t890r7xp	107	50	we	-PRON-	PRP
cord-283382-t890r7xp	107	51	can	can	MD
cord-283382-t890r7xp	107	52	engineer	engineer	VB
cord-283382-t890r7xp	107	53	Ad	ad	NN
cord-283382-t890r7xp	107	54	vectors	vector	NNS
cord-283382-t890r7xp	107	55	which	which	WDT
cord-283382-t890r7xp	107	56	are	be	VBP
cord-283382-t890r7xp	107	57	targeted	target	VBN
cord-283382-t890r7xp	107	58	to	to	IN
cord-283382-t890r7xp	107	59	specific	specific	JJ
cord-283382-t890r7xp	107	60	receptors	receptor	NNS
cord-283382-t890r7xp	107	61	on	on	IN
cord-283382-t890r7xp	107	62	the	the	DT
cord-283382-t890r7xp	107	63	surface	surface	NN
cord-283382-t890r7xp	107	64	of	of	IN
cord-283382-t890r7xp	107	65	DCs	dc	NNS
cord-283382-t890r7xp	107	66	(	(	-LRB-
cord-283382-t890r7xp	107	67	93	93	CD
cord-283382-t890r7xp	107	68	,	,	,
cord-283382-t890r7xp	107	69	94	94	CD
cord-283382-t890r7xp	107	70	)	)	-RRB-
cord-283382-t890r7xp	107	71	.	.	.
cord-283382-t890r7xp	108	1	Receptors	receptor	NNS
cord-283382-t890r7xp	108	2	on	on	IN
cord-283382-t890r7xp	108	3	the	the	DT
cord-283382-t890r7xp	108	4	surface	surface	NN
cord-283382-t890r7xp	108	5	of	of	IN
cord-283382-t890r7xp	108	6	dendritic	dendritic	JJ
cord-283382-t890r7xp	108	7	cells	cell	NNS
cord-283382-t890r7xp	108	8	(	(	-LRB-
cord-283382-t890r7xp	108	9	DCs	DCs	NNP
cord-283382-t890r7xp	108	10	)	)	-RRB-
cord-283382-t890r7xp	108	11	can	can	MD
cord-283382-t890r7xp	108	12	permit	permit	VB
cord-283382-t890r7xp	108	13	entry	entry	NN
cord-283382-t890r7xp	108	14	of	of	IN
cord-283382-t890r7xp	108	15	Ads	ad	NNS
cord-283382-t890r7xp	108	16	independently	independently	RB
cord-283382-t890r7xp	108	17	of	of	IN
cord-283382-t890r7xp	108	18	the	the	DT
cord-283382-t890r7xp	108	19	classical	classical	JJ
cord-283382-t890r7xp	108	20	CAR	car	NN
cord-283382-t890r7xp	108	21	receptor	receptor	NN
cord-283382-t890r7xp	108	22	,	,	,
cord-283382-t890r7xp	108	23	which	which	WDT
cord-283382-t890r7xp	108	24	is	be	VBZ
cord-283382-t890r7xp	108	25	largely	largely	RB
cord-283382-t890r7xp	108	26	absent	absent	JJ
cord-283382-t890r7xp	108	27	on	on	IN
cord-283382-t890r7xp	108	28	DCs	dc	NNS
cord-283382-t890r7xp	108	29	(	(	-LRB-
cord-283382-t890r7xp	108	30	95	95	CD
cord-283382-t890r7xp	108	31	)	)	-RRB-
cord-283382-t890r7xp	108	32	.	.	.
cord-283382-t890r7xp	109	1	Receptors	receptor	NNS
cord-283382-t890r7xp	109	2	proposed	propose	VBD
cord-283382-t890r7xp	109	3	to	to	TO
cord-283382-t890r7xp	109	4	be	be	VB
cord-283382-t890r7xp	109	5	involved	involve	VBN
cord-283382-t890r7xp	109	6	in	in	IN
cord-283382-t890r7xp	109	7	Ad	ad	NN
cord-283382-t890r7xp	109	8	viral	viral	JJ
cord-283382-t890r7xp	109	9	entry	entry	NN
cord-283382-t890r7xp	109	10	into	into	IN
cord-283382-t890r7xp	109	11	human	human	JJ
cord-283382-t890r7xp	109	12	or	or	CC
cord-283382-t890r7xp	109	13	murine	murine	JJ
cord-283382-t890r7xp	109	14	DCs	dc	NNS
cord-283382-t890r7xp	109	15	include	include	VBP
cord-283382-t890r7xp	109	16	Dendritic	Dendritic	NNP
cord-283382-t890r7xp	109	17	Cell	Cell	NNP
cord-283382-t890r7xp	109	18	-	-	HYPH
cord-283382-t890r7xp	109	19	Specific	specific	JJ
cord-283382-t890r7xp	109	20	Intercellular	Intercellular	NNP
cord-283382-t890r7xp	109	21	adhesion	adhesion	NN
cord-283382-t890r7xp	109	22	molecule-3-Grabbing	molecule-3-Grabbing	NNP
cord-283382-t890r7xp	109	23	Nonintegrin	Nonintegrin	NNP
cord-283382-t890r7xp	109	24	(	(	-LRB-
cord-283382-t890r7xp	109	25	DC	DC	NNP
cord-283382-t890r7xp	109	26	-	-	HYPH
cord-283382-t890r7xp	109	27	SIGN	SIGN	NNP
cord-283382-t890r7xp	109	28	)	)	-RRB-
cord-283382-t890r7xp	109	29	(	(	-LRB-
cord-283382-t890r7xp	109	30	95	95	CD
cord-283382-t890r7xp	109	31	)	)	-RRB-
cord-283382-t890r7xp	109	32	,	,	,
cord-283382-t890r7xp	109	33	CD46	CD46	NNP
cord-283382-t890r7xp	109	34	(	(	-LRB-
cord-283382-t890r7xp	109	35	61	61	CD
cord-283382-t890r7xp	109	36	,	,	,
cord-283382-t890r7xp	109	37	96	96	CD
cord-283382-t890r7xp	109	38	,	,	,
cord-283382-t890r7xp	109	39	97	97	CD
cord-283382-t890r7xp	109	40	)	)	-RRB-
cord-283382-t890r7xp	109	41	,	,	,
cord-283382-t890r7xp	109	42	or	or	CC
cord-283382-t890r7xp	109	43	CD80	CD80	NNP
cord-283382-t890r7xp	109	44	/	/	SYM
cord-283382-t890r7xp	109	45	CD86	CD86	NNP
cord-283382-t890r7xp	109	46	(	(	-LRB-
cord-283382-t890r7xp	109	47	98	98	CD
cord-283382-t890r7xp	109	48	)	)	-RRB-
cord-283382-t890r7xp	109	49	.	.	.
cord-283382-t890r7xp	110	1	A	a	DT
cord-283382-t890r7xp	110	2	vector	vector	NN
cord-283382-t890r7xp	110	3	based	base	VBN
cord-283382-t890r7xp	110	4	on	on	IN
cord-283382-t890r7xp	110	5	chimpanzee	chimpanzee	NN
cord-283382-t890r7xp	110	6	Ad	ad	NN
cord-283382-t890r7xp	110	7	vector	vector	NN
cord-283382-t890r7xp	110	8	1	1	CD
cord-283382-t890r7xp	110	9	,	,	,
cord-283382-t890r7xp	110	10	ChAdV-1	ChAdV-1	NNP
cord-283382-t890r7xp	110	11	,	,	,
cord-283382-t890r7xp	110	12	was	be	VBD
cord-283382-t890r7xp	110	13	shown	show	VBN
cord-283382-t890r7xp	110	14	to	to	TO
cord-283382-t890r7xp	110	15	efficiently	efficiently	RB
cord-283382-t890r7xp	110	16	transduce	transduce	VB
cord-283382-t890r7xp	110	17	CD46-expressing	cd46-expresse	VBG
cord-283382-t890r7xp	110	18	murine	murine	JJ
cord-283382-t890r7xp	110	19	DCs	dc	NNS
cord-283382-t890r7xp	110	20	in	in	IN
cord-283382-t890r7xp	110	21	vitro	vitro	FW
cord-283382-t890r7xp	110	22	(	(	-LRB-
cord-283382-t890r7xp	110	23	97	97	CD
cord-283382-t890r7xp	110	24	)	)	-RRB-
cord-283382-t890r7xp	110	25	.	.	.
cord-283382-t890r7xp	111	1	Recombinant	recombinant	JJ
cord-283382-t890r7xp	111	2	Ad5	ad5	CD
cord-283382-t890r7xp	111	3	vectors	vector	NNS
cord-283382-t890r7xp	111	4	pseudotyped	pseudotyped	NNP
cord-283382-t890r7xp	111	5	with	with	IN
cord-283382-t890r7xp	111	6	the	the	DT
cord-283382-t890r7xp	111	7	fiber	fiber	NN
cord-283382-t890r7xp	111	8	knob	knob	NN
cord-283382-t890r7xp	111	9	from	from	IN
cord-283382-t890r7xp	111	10	Ad3	ad3	CD
cord-283382-t890r7xp	111	11	(	(	-LRB-
cord-283382-t890r7xp	111	12	99	99	CD
cord-283382-t890r7xp	111	13	)	)	-RRB-
cord-283382-t890r7xp	111	14	or	or	CC
cord-283382-t890r7xp	111	15	porcine	porcine	JJ
cord-283382-t890r7xp	111	16	adenovirus	adenovirus	NN
cord-283382-t890r7xp	111	17	type	type	NN
cord-283382-t890r7xp	111	18	4	4	CD
cord-283382-t890r7xp	111	19	(	(	-LRB-
cord-283382-t890r7xp	111	20	100	100	CD
cord-283382-t890r7xp	111	21	)	)	-RRB-
cord-283382-t890r7xp	111	22	,	,	,
cord-283382-t890r7xp	111	23	can	can	MD
cord-283382-t890r7xp	111	24	increase	increase	VB
cord-283382-t890r7xp	111	25	entry	entry	NN
cord-283382-t890r7xp	111	26	into	into	IN
cord-283382-t890r7xp	111	27	human	human	JJ
cord-283382-t890r7xp	111	28	DCs	dc	NNS
cord-283382-t890r7xp	111	29	,	,	,
cord-283382-t890r7xp	111	30	via	via	IN
cord-283382-t890r7xp	111	31	CD80	CD80	NNP
cord-283382-t890r7xp	111	32	/	/	SYM
cord-283382-t890r7xp	111	33	CD86	CD86	NNP
cord-283382-t890r7xp	111	34	and	and	CC
cord-283382-t890r7xp	111	35	surface	surface	NN
cord-283382-t890r7xp	111	36	glycans	glycan	NNS
cord-283382-t890r7xp	111	37	,	,	,
cord-283382-t890r7xp	111	38	respectively	respectively	RB
cord-283382-t890r7xp	111	39	.	.	.
cord-283382-t890r7xp	112	1	Similarly	similarly	RB
cord-283382-t890r7xp	112	2	,	,	,
cord-283382-t890r7xp	112	3	pseudotyping	pseudotype	VBG
cord-283382-t890r7xp	112	4	rAd5	rAd5	''
cord-283382-t890r7xp	112	5	with	with	IN
cord-283382-t890r7xp	112	6	the	the	DT
cord-283382-t890r7xp	112	7	fibers	fiber	NNS
cord-283382-t890r7xp	112	8	from	from	IN
cord-283382-t890r7xp	112	9	species	specie	NNS
cord-283382-t890r7xp	112	10	B	b	NN
cord-283382-t890r7xp	112	11	,	,	,
cord-283382-t890r7xp	112	12	HAdV	HAdV	NNP
cord-283382-t890r7xp	112	13	-	-	HYPH
cord-283382-t890r7xp	112	14	B16	b16	NN
cord-283382-t890r7xp	112	15	or	or	CC
cord-283382-t890r7xp	112	16	species	species	NN
cord-283382-t890r7xp	112	17	D	d	NN
cord-283382-t890r7xp	112	18	,	,	,
cord-283382-t890r7xp	112	19	HAdV	HAdV	NNP
cord-283382-t890r7xp	112	20	-	-	HYPH
cord-283382-t890r7xp	112	21	D37	D37	NNP
cord-283382-t890r7xp	112	22	displayed	display	VBD
cord-283382-t890r7xp	112	23	increased	increase	VBN
cord-283382-t890r7xp	112	24	entry	entry	NN
cord-283382-t890r7xp	112	25	into	into	IN
cord-283382-t890r7xp	112	26	murine	murine	JJ
cord-283382-t890r7xp	112	27	DCs	dc	NNS
cord-283382-t890r7xp	112	28	compared	compare	VBN
cord-283382-t890r7xp	112	29	with	with	IN
cord-283382-t890r7xp	112	30	unmodified	unmodified	JJ
cord-283382-t890r7xp	112	31	rAd5	rAd5	''
cord-283382-t890r7xp	112	32	(	(	-LRB-
cord-283382-t890r7xp	112	33	101	101	CD
cord-283382-t890r7xp	112	34	)	)	-RRB-
cord-283382-t890r7xp	112	35	.	.	.
cord-283382-t890r7xp	113	1	Interestingly	interestingly	RB
cord-283382-t890r7xp	113	2	,	,	,
cord-283382-t890r7xp	113	3	in	in	IN
cord-283382-t890r7xp	113	4	the	the	DT
cord-283382-t890r7xp	113	5	latter	latter	JJ
cord-283382-t890r7xp	113	6	study	study	NN
cord-283382-t890r7xp	113	7	,	,	,
cord-283382-t890r7xp	113	8	increased	increase	VBN
cord-283382-t890r7xp	113	9	entry	entry	NN
cord-283382-t890r7xp	113	10	into	into	IN
cord-283382-t890r7xp	113	11	DCs	DCs	NNP
cord-283382-t890r7xp	113	12	was	be	VBD
cord-283382-t890r7xp	113	13	not	not	RB
cord-283382-t890r7xp	113	14	associated	associate	VBN
cord-283382-t890r7xp	113	15	with	with	IN
cord-283382-t890r7xp	113	16	improved	improved	JJ
cord-283382-t890r7xp	113	17	cellular	cellular	JJ
cord-283382-t890r7xp	113	18	immunity	immunity	NN
cord-283382-t890r7xp	113	19	following	follow	VBG
cord-283382-t890r7xp	113	20	subcutaneous	subcutaneous	JJ
cord-283382-t890r7xp	113	21	immunization	immunization	NN
cord-283382-t890r7xp	113	22	.	.	.
cord-283382-t890r7xp	114	1	In	in	IN
cord-283382-t890r7xp	114	2	support	support	NN
cord-283382-t890r7xp	114	3	of	of	IN
cord-283382-t890r7xp	114	4	this	this	DT
cord-283382-t890r7xp	114	5	,	,	,
cord-283382-t890r7xp	114	6	species	specie	NNS
cord-283382-t890r7xp	114	7	B	b	NN
cord-283382-t890r7xp	114	8	Ad	ad	NN
cord-283382-t890r7xp	114	9	vectors	vector	NNS
cord-283382-t890r7xp	114	10	,	,	,
cord-283382-t890r7xp	114	11	including	include	VBG
cord-283382-t890r7xp	114	12	Ad35	Ad35	NNP
cord-283382-t890r7xp	114	13	,	,	,
cord-283382-t890r7xp	114	14	were	be	VBD
cord-283382-t890r7xp	114	15	long	long	RB
cord-283382-t890r7xp	114	16	considered	consider	VBN
cord-283382-t890r7xp	114	17	to	to	TO
cord-283382-t890r7xp	114	18	hold	hold	VB
cord-283382-t890r7xp	114	19	great	great	JJ
cord-283382-t890r7xp	114	20	potential	potential	NN
cord-283382-t890r7xp	114	21	as	as	IN
cord-283382-t890r7xp	114	22	potently	potently	RB
cord-283382-t890r7xp	114	23	immunogenic	immunogenic	JJ
cord-283382-t890r7xp	114	24	vaccine	vaccine	NN
cord-283382-t890r7xp	114	25	vectors	vector	NNS
cord-283382-t890r7xp	114	26	due	due	IN
cord-283382-t890r7xp	114	27	to	to	IN
cord-283382-t890r7xp	114	28	their	-PRON-	PRP$
cord-283382-t890r7xp	114	29	increased	increase	VBN
cord-283382-t890r7xp	114	30	ability	ability	NN
cord-283382-t890r7xp	114	31	to	to	TO
cord-283382-t890r7xp	114	32	target	target	VB
cord-283382-t890r7xp	114	33	both	both	DT
cord-283382-t890r7xp	114	34	myeloid	myeloid	JJ
cord-283382-t890r7xp	114	35	and	and	CC
cord-283382-t890r7xp	114	36	plasmacytoid	plasmacytoid	NNP
cord-283382-t890r7xp	114	37	human	human	JJ
cord-283382-t890r7xp	114	38	DCs	dc	NNS
cord-283382-t890r7xp	114	39	via	via	IN
cord-283382-t890r7xp	114	40	CD46	CD46	NNP
cord-283382-t890r7xp	114	41	.	.	.
cord-283382-t890r7xp	115	1	However	however	RB
cord-283382-t890r7xp	115	2	,	,	,
cord-283382-t890r7xp	115	3	these	these	DT
cord-283382-t890r7xp	115	4	vectors	vector	NNS
cord-283382-t890r7xp	115	5	were	be	VBD
cord-283382-t890r7xp	115	6	subsequently	subsequently	RB
cord-283382-t890r7xp	115	7	shown	show	VBN
cord-283382-t890r7xp	115	8	to	to	TO
cord-283382-t890r7xp	115	9	be	be	VB
cord-283382-t890r7xp	115	10	some	some	DT
cord-283382-t890r7xp	115	11	of	of	IN
cord-283382-t890r7xp	115	12	the	the	DT
cord-283382-t890r7xp	115	13	least	least	JJS
cord-283382-t890r7xp	115	14	potent	potent	JJ
cord-283382-t890r7xp	115	15	Ad	ad	NN
cord-283382-t890r7xp	115	16	vaccines	vaccine	NNS
cord-283382-t890r7xp	115	17	in	in	IN
cord-283382-t890r7xp	115	18	vivo	vivo	NNP
cord-283382-t890r7xp	115	19	(	(	-LRB-
cord-283382-t890r7xp	115	20	5	5	CD
cord-283382-t890r7xp	115	21	,	,	,
cord-283382-t890r7xp	115	22	8)	8)	NN
cord-283382-t890r7xp	115	23	.	.	.
cord-283382-t890r7xp	116	1	These	these	DT
cord-283382-t890r7xp	116	2	observations	observation	NNS
cord-283382-t890r7xp	116	3	and	and	CC
cord-283382-t890r7xp	116	4	findings	finding	NNS
cord-283382-t890r7xp	116	5	are	be	VBP
cord-283382-t890r7xp	116	6	important	important	JJ
cord-283382-t890r7xp	116	7	in	in	IN
cord-283382-t890r7xp	116	8	highlighting	highlight	VBG
cord-283382-t890r7xp	116	9	that	that	IN
cord-283382-t890r7xp	116	10	multiple	multiple	JJ
cord-283382-t890r7xp	116	11	parameters	parameter	NNS
cord-283382-t890r7xp	116	12	,	,	,
cord-283382-t890r7xp	116	13	such	such	JJ
cord-283382-t890r7xp	116	14	as	as	IN
cord-283382-t890r7xp	116	15	post	post	JJ
cord-283382-t890r7xp	116	16	-	-	JJ
cord-283382-t890r7xp	116	17	entry	entry	JJ
cord-283382-t890r7xp	116	18	intracellular	intracellular	JJ
cord-283382-t890r7xp	116	19	trafficking	traffic	VBG
cord-283382-t890r7xp	116	20	kinetics	kinetic	NNS
cord-283382-t890r7xp	116	21	or	or	CC
cord-283382-t890r7xp	116	22	differential	differential	JJ
cord-283382-t890r7xp	116	23	activation	activation	NN
cord-283382-t890r7xp	116	24	of	of	IN
cord-283382-t890r7xp	116	25	innate	innate	JJ
cord-283382-t890r7xp	116	26	immune	immune	JJ
cord-283382-t890r7xp	116	27	signaling	signal	VBG
cord-283382-t890r7xp	116	28	pathways	pathway	NNS
cord-283382-t890r7xp	116	29	,	,	,
cord-283382-t890r7xp	116	30	not	not	RB
cord-283382-t890r7xp	116	31	just	just	RB
cord-283382-t890r7xp	116	32	viral	viral	JJ
cord-283382-t890r7xp	116	33	tropism	tropism	NN
cord-283382-t890r7xp	116	34	,	,	,
cord-283382-t890r7xp	116	35	likely	likely	RB
cord-283382-t890r7xp	116	36	play	play	VB
cord-283382-t890r7xp	116	37	key	key	JJ
cord-283382-t890r7xp	116	38	roles	role	NNS
cord-283382-t890r7xp	116	39	in	in	IN
cord-283382-t890r7xp	116	40	the	the	DT
cord-283382-t890r7xp	116	41	induction	induction	NN
cord-283382-t890r7xp	116	42	of	of	IN
cord-283382-t890r7xp	116	43	robust	robust	JJ
cord-283382-t890r7xp	116	44	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	116	45	.	.	.
cord-283382-t890r7xp	117	1	The	the	DT
cord-283382-t890r7xp	117	2	ability	ability	NN
cord-283382-t890r7xp	117	3	of	of	IN
cord-283382-t890r7xp	117	4	diverse	diverse	JJ
cord-283382-t890r7xp	117	5	rAd	rAd	NNS
cord-283382-t890r7xp	117	6	vaccines	vaccine	NNS
cord-283382-t890r7xp	117	7	to	to	TO
cord-283382-t890r7xp	117	8	elicit	elicit	VB
cord-283382-t890r7xp	117	9	robust	robust	JJ
cord-283382-t890r7xp	117	10	cellular	cellular	JJ
cord-283382-t890r7xp	117	11	immune	immune	JJ
cord-283382-t890r7xp	117	12	responses	response	NNS
cord-283382-t890r7xp	117	13	and	and	CC
cord-283382-t890r7xp	117	14	confer	confer	VB
cord-283382-t890r7xp	117	15	protective	protective	JJ
cord-283382-t890r7xp	117	16	immunity	immunity	NN
cord-283382-t890r7xp	117	17	in	in	IN
cord-283382-t890r7xp	117	18	animal	animal	NN
cord-283382-t890r7xp	117	19	models	model	NNS
cord-283382-t890r7xp	117	20	makes	make	VBZ
cord-283382-t890r7xp	117	21	them	-PRON-	PRP
cord-283382-t890r7xp	117	22	an	an	DT
cord-283382-t890r7xp	117	23	attractive	attractive	JJ
cord-283382-t890r7xp	117	24	vector	vector	NN
cord-283382-t890r7xp	117	25	platform	platform	NN
cord-283382-t890r7xp	117	26	for	for	IN
cord-283382-t890r7xp	117	27	vaccine	vaccine	NN
cord-283382-t890r7xp	117	28	development	development	NN
cord-283382-t890r7xp	117	29	(	(	-LRB-
cord-283382-t890r7xp	117	30	Table	Table	NNP
cord-283382-t890r7xp	117	31	2	2	CD
cord-283382-t890r7xp	117	32	)	)	-RRB-
cord-283382-t890r7xp	117	33	.	.	.
cord-283382-t890r7xp	118	1	In	in	IN
cord-283382-t890r7xp	118	2	addition	addition	NN
cord-283382-t890r7xp	118	3	to	to	IN
cord-283382-t890r7xp	118	4	this	this	DT
cord-283382-t890r7xp	118	5	,	,	,
cord-283382-t890r7xp	118	6	their	-PRON-	PRP$
cord-283382-t890r7xp	118	7	safety	safety	NN
cord-283382-t890r7xp	118	8	in	in	IN
cord-283382-t890r7xp	118	9	clinical	clinical	JJ
cord-283382-t890r7xp	118	10	applications	application	NNS
cord-283382-t890r7xp	118	11	,	,	,
cord-283382-t890r7xp	118	12	compatibility	compatibility	NN
cord-283382-t890r7xp	118	13	with	with	IN
cord-283382-t890r7xp	118	14	clinical	clinical	JJ
cord-283382-t890r7xp	118	15	-	-	HYPH
cord-283382-t890r7xp	118	16	grade	grade	NN
cord-283382-t890r7xp	118	17	manufacturing	manufacturing	NN
cord-283382-t890r7xp	118	18	and	and	CC
cord-283382-t890r7xp	118	19	scale	scale	NN
cord-283382-t890r7xp	118	20	-	-	HYPH
cord-283382-t890r7xp	118	21	up	up	NN
cord-283382-t890r7xp	118	22	(	(	-LRB-
cord-283382-t890r7xp	118	23	102	102	CD
cord-283382-t890r7xp	118	24	,	,	,
cord-283382-t890r7xp	118	25	103	103	CD
cord-283382-t890r7xp	118	26	)	)	-RRB-
cord-283382-t890r7xp	118	27	and	and	CC
cord-283382-t890r7xp	118	28	their	-PRON-	PRP$
cord-283382-t890r7xp	118	29	suitability	suitability	NN
cord-283382-t890r7xp	118	30	for	for	IN
cord-283382-t890r7xp	118	31	long	long	JJ
cord-283382-t890r7xp	118	32	-	-	HYPH
cord-283382-t890r7xp	118	33	term	term	NN
cord-283382-t890r7xp	118	34	storage	storage	NN
cord-283382-t890r7xp	118	35	(	(	-LRB-
cord-283382-t890r7xp	118	36	104	104	CD
cord-283382-t890r7xp	118	37	)	)	-RRB-
cord-283382-t890r7xp	118	38	,	,	,
cord-283382-t890r7xp	118	39	or	or	CC
cord-283382-t890r7xp	118	40	thermo	thermo	NN
cord-283382-t890r7xp	118	41	-	-	HYPH
cord-283382-t890r7xp	118	42	stabilization	stabilization	NN
cord-283382-t890r7xp	118	43	(	(	-LRB-
cord-283382-t890r7xp	118	44	105	105	CD
cord-283382-t890r7xp	118	45	)	)	-RRB-
cord-283382-t890r7xp	118	46	(	(	-LRB-
cord-283382-t890r7xp	118	47	106	106	CD
cord-283382-t890r7xp	118	48	)	)	-RRB-
cord-283382-t890r7xp	118	49	(	(	-LRB-
cord-283382-t890r7xp	118	50	107	107	CD
cord-283382-t890r7xp	118	51	)	)	-RRB-
cord-283382-t890r7xp	118	52	and	and	CC
cord-283382-t890r7xp	118	53	stockpiling	stockpile	VBG
cord-283382-t890r7xp	118	54	for	for	IN
cord-283382-t890r7xp	118	55	cold	cold	JJ
cord-283382-t890r7xp	118	56	-	-	HYPH
cord-283382-t890r7xp	118	57	chain	chain	NN
cord-283382-t890r7xp	118	58	free	free	JJ
cord-283382-t890r7xp	118	59	storage	storage	NN
cord-283382-t890r7xp	118	60	,	,	,
cord-283382-t890r7xp	118	61	has	have	VBZ
cord-283382-t890r7xp	118	62	solidified	solidify	VBN
cord-283382-t890r7xp	118	63	their	-PRON-	PRP$
cord-283382-t890r7xp	118	64	appeal	appeal	NN
cord-283382-t890r7xp	118	65	as	as	IN
cord-283382-t890r7xp	118	66	vaccines	vaccine	NNS
cord-283382-t890r7xp	118	67	for	for	IN
cord-283382-t890r7xp	118	68	major	major	JJ
cord-283382-t890r7xp	118	69	infectious	infectious	JJ
cord-283382-t890r7xp	118	70	diseases	disease	NNS
cord-283382-t890r7xp	118	71	(	(	-LRB-
cord-283382-t890r7xp	118	72	108	108	CD
cord-283382-t890r7xp	118	73	)	)	-RRB-
cord-283382-t890r7xp	118	74	.	.	.
cord-283382-t890r7xp	119	1	It	-PRON-	PRP
cord-283382-t890r7xp	119	2	is	be	VBZ
cord-283382-t890r7xp	119	3	this	this	DT
cord-283382-t890r7xp	119	4	clear	clear	JJ
cord-283382-t890r7xp	119	5	translational	translational	JJ
cord-283382-t890r7xp	119	6	potential	potential	NN
cord-283382-t890r7xp	119	7	which	which	WDT
cord-283382-t890r7xp	119	8	has	have	VBZ
cord-283382-t890r7xp	119	9	emphasized	emphasize	VBN
cord-283382-t890r7xp	119	10	the	the	DT
cord-283382-t890r7xp	119	11	importance	importance	NN
cord-283382-t890r7xp	119	12	of	of	IN
cord-283382-t890r7xp	119	13	improving	improve	VBG
cord-283382-t890r7xp	119	14	our	-PRON-	PRP$
cord-283382-t890r7xp	119	15	understanding	understanding	NN
cord-283382-t890r7xp	119	16	of	of	IN
cord-283382-t890r7xp	119	17	the	the	DT
cord-283382-t890r7xp	119	18	mechanisms	mechanism	NNS
cord-283382-t890r7xp	119	19	which	which	WDT
cord-283382-t890r7xp	119	20	underlie	underlie	VBP
cord-283382-t890r7xp	119	21	differences	difference	NNS
cord-283382-t890r7xp	119	22	in	in	IN
cord-283382-t890r7xp	119	23	the	the	DT
cord-283382-t890r7xp	119	24	immunological	immunological	JJ
cord-283382-t890r7xp	119	25	potency	potency	NN
cord-283382-t890r7xp	119	26	of	of	IN
cord-283382-t890r7xp	119	27	diverse	diverse	JJ
cord-283382-t890r7xp	119	28	Ad	ad	NN
cord-283382-t890r7xp	119	29	types	type	NNS
cord-283382-t890r7xp	119	30	.	.	.
cord-283382-t890r7xp	120	1	Ad	ad	NN
cord-283382-t890r7xp	120	2	vectors	vector	NNS
cord-283382-t890r7xp	120	3	are	be	VBP
cord-283382-t890r7xp	120	4	capable	capable	JJ
cord-283382-t890r7xp	120	5	of	of	IN
cord-283382-t890r7xp	120	6	triggering	trigger	VBG
cord-283382-t890r7xp	120	7	multiple	multiple	JJ
cord-283382-t890r7xp	120	8	innate	innate	JJ
cord-283382-t890r7xp	120	9	immune	immune	JJ
cord-283382-t890r7xp	120	10	sensors	sensor	NNS
cord-283382-t890r7xp	120	11	at	at	IN
cord-283382-t890r7xp	120	12	several	several	JJ
cord-283382-t890r7xp	120	13	steps	step	NNS
cord-283382-t890r7xp	120	14	in	in	IN
cord-283382-t890r7xp	120	15	the	the	DT
cord-283382-t890r7xp	120	16	viral	viral	JJ
cord-283382-t890r7xp	120	17	entry	entry	NN
cord-283382-t890r7xp	120	18	pathway	pathway	NN
cord-283382-t890r7xp	120	19	(	(	-LRB-
cord-283382-t890r7xp	120	20	109	109	CD
cord-283382-t890r7xp	120	21	,	,	,
cord-283382-t890r7xp	120	22	110	110	CD
cord-283382-t890r7xp	120	23	)	)	-RRB-
cord-283382-t890r7xp	120	24	,	,	,
cord-283382-t890r7xp	120	25	in	in	IN
cord-283382-t890r7xp	120	26	a	a	DT
cord-283382-t890r7xp	120	27	process	process	NN
cord-283382-t890r7xp	120	28	which	which	WDT
cord-283382-t890r7xp	120	29	does	do	VBZ
cord-283382-t890r7xp	120	30	not	not	RB
cord-283382-t890r7xp	120	31	require	require	VB
cord-283382-t890r7xp	120	32	viral	viral	JJ
cord-283382-t890r7xp	120	33	replication	replication	NN
cord-283382-t890r7xp	120	34	or	or	CC
cord-283382-t890r7xp	120	35	gene	gene	NN
cord-283382-t890r7xp	120	36	expression	expression	NN
cord-283382-t890r7xp	120	37	(	(	-LRB-
cord-283382-t890r7xp	120	38	111	111	CD
cord-283382-t890r7xp	120	39	)	)	-RRB-
cord-283382-t890r7xp	120	40	.	.	.
cord-283382-t890r7xp	121	1	Viral	Viral	NNP
cord-283382-t890r7xp	121	2	penton	penton	NNP
cord-283382-t890r7xp	121	3	RGD	RGD	NNP
cord-283382-t890r7xp	121	4	:	:	:
cord-283382-t890r7xp	121	5	cellular	cellular	JJ
cord-283382-t890r7xp	121	6	integrin	integrin	NN
cord-283382-t890r7xp	121	7	-	-	HYPH
cord-283382-t890r7xp	121	8	mediated	mediate	VBN
cord-283382-t890r7xp	121	9	internalization	internalization	NN
cord-283382-t890r7xp	121	10	and	and	CC
cord-283382-t890r7xp	121	11	subsequent	subsequent	JJ
cord-283382-t890r7xp	121	12	escape	escape	NN
cord-283382-t890r7xp	121	13	from	from	IN
cord-283382-t890r7xp	121	14	the	the	DT
cord-283382-t890r7xp	121	15	endosome	endosome	NN
cord-283382-t890r7xp	121	16	is	be	VBZ
cord-283382-t890r7xp	121	17	considered	consider	VBN
cord-283382-t890r7xp	121	18	to	to	TO
cord-283382-t890r7xp	121	19	be	be	VB
cord-283382-t890r7xp	121	20	a	a	DT
cord-283382-t890r7xp	121	21	crucial	crucial	JJ
cord-283382-t890r7xp	121	22	step	step	NN
cord-283382-t890r7xp	121	23	in	in	IN
cord-283382-t890r7xp	121	24	activating	activate	VBG
cord-283382-t890r7xp	121	25	many	many	JJ
cord-283382-t890r7xp	121	26	innate	innate	JJ
cord-283382-t890r7xp	121	27	immune	immune	JJ
cord-283382-t890r7xp	121	28	responses	response	NNS
cord-283382-t890r7xp	121	29	to	to	IN
cord-283382-t890r7xp	121	30	Ad	ad	NN
cord-283382-t890r7xp	121	31	vaccines	vaccine	NNS
cord-283382-t890r7xp	121	32	(	(	-LRB-
cord-283382-t890r7xp	121	33	112	112	CD
cord-283382-t890r7xp	121	34	)	)	-RRB-
cord-283382-t890r7xp	121	35	.	.	.
cord-283382-t890r7xp	122	1	It	-PRON-	PRP
cord-283382-t890r7xp	122	2	is	be	VBZ
cord-283382-t890r7xp	122	3	considered	consider	VBN
cord-283382-t890r7xp	122	4	that	that	IN
cord-283382-t890r7xp	122	5	preferential	preferential	JJ
cord-283382-t890r7xp	122	6	stimulation	stimulation	NN
cord-283382-t890r7xp	122	7	(	(	-LRB-
cord-283382-t890r7xp	122	8	or	or	CC
cord-283382-t890r7xp	122	9	avoidance	avoidance	NN
cord-283382-t890r7xp	122	10	)	)	-RRB-
cord-283382-t890r7xp	122	11	of	of	IN
cord-283382-t890r7xp	122	12	defined	define	VBN
cord-283382-t890r7xp	122	13	innate	innate	JJ
cord-283382-t890r7xp	122	14	immune	immune	JJ
cord-283382-t890r7xp	122	15	signaling	signal	VBG
cord-283382-t890r7xp	122	16	pathways	pathway	NNS
cord-283382-t890r7xp	122	17	could	could	MD
cord-283382-t890r7xp	122	18	impact	impact	VB
cord-283382-t890r7xp	122	19	on	on	IN
cord-283382-t890r7xp	122	20	the	the	DT
cord-283382-t890r7xp	122	21	downstream	downstream	JJ
cord-283382-t890r7xp	122	22	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	122	23	of	of	IN
cord-283382-t890r7xp	122	24	distinct	distinct	JJ
cord-283382-t890r7xp	122	25	Ad	ad	NN
cord-283382-t890r7xp	122	26	vectors	vector	NNS
cord-283382-t890r7xp	122	27	.	.	.
cord-283382-t890r7xp	123	1	With	with	IN
cord-283382-t890r7xp	123	2	regard	regard	NN
cord-283382-t890r7xp	123	3	to	to	IN
cord-283382-t890r7xp	123	4	assessing	assess	VBG
cord-283382-t890r7xp	123	5	the	the	DT
cord-283382-t890r7xp	123	6	differential	differential	JJ
cord-283382-t890r7xp	123	7	stimulation	stimulation	NN
cord-283382-t890r7xp	123	8	of	of	IN
cord-283382-t890r7xp	123	9	innate	innate	JJ
cord-283382-t890r7xp	123	10	immune	immune	JJ
cord-283382-t890r7xp	123	11	signaling	signal	VBG
cord-283382-t890r7xp	123	12	pathways	pathway	NNS
cord-283382-t890r7xp	123	13	,	,	,
cord-283382-t890r7xp	123	14	this	this	DT
cord-283382-t890r7xp	123	15	is	be	VBZ
cord-283382-t890r7xp	123	16	complicated	complicate	VBN
cord-283382-t890r7xp	123	17	by	by	IN
cord-283382-t890r7xp	123	18	the	the	DT
cord-283382-t890r7xp	123	19	fact	fact	NN
cord-283382-t890r7xp	123	20	that	that	IN
cord-283382-t890r7xp	123	21	many	many	JJ
cord-283382-t890r7xp	123	22	vectors	vector	NNS
cord-283382-t890r7xp	123	23	have	have	VBP
cord-283382-t890r7xp	123	24	not	not	RB
cord-283382-t890r7xp	123	25	been	be	VBN
cord-283382-t890r7xp	123	26	compared	compare	VBN
cord-283382-t890r7xp	123	27	side	side	NN
cord-283382-t890r7xp	123	28	-	-	HYPH
cord-283382-t890r7xp	123	29	byside	byside	NN
cord-283382-t890r7xp	123	30	,	,	,
cord-283382-t890r7xp	123	31	and	and	CC
cord-283382-t890r7xp	123	32	published	publish	VBN
cord-283382-t890r7xp	123	33	data	datum	NNS
cord-283382-t890r7xp	123	34	proposing	propose	VBG
cord-283382-t890r7xp	123	35	roles	role	NNS
cord-283382-t890r7xp	123	36	for	for	IN
cord-283382-t890r7xp	123	37	these	these	DT
cord-283382-t890r7xp	123	38	pathways	pathway	NNS
cord-283382-t890r7xp	123	39	in	in	IN
cord-283382-t890r7xp	123	40	the	the	DT
cord-283382-t890r7xp	123	41	immunological	immunological	JJ
cord-283382-t890r7xp	123	42	potency	potency	NN
cord-283382-t890r7xp	123	43	of	of	IN
cord-283382-t890r7xp	123	44	different	different	JJ
cord-283382-t890r7xp	123	45	Ad	ad	NN
cord-283382-t890r7xp	123	46	vectors	vector	NNS
cord-283382-t890r7xp	123	47	are	be	VBP
cord-283382-t890r7xp	123	48	often	often	RB
cord-283382-t890r7xp	123	49	contradictory	contradictory	JJ
cord-283382-t890r7xp	123	50	.	.	.
cord-283382-t890r7xp	124	1	However	however	RB
cord-283382-t890r7xp	124	2	,	,	,
cord-283382-t890r7xp	124	3	a	a	DT
cord-283382-t890r7xp	124	4	number	number	NN
cord-283382-t890r7xp	124	5	of	of	IN
cord-283382-t890r7xp	124	6	pathways	pathway	NNS
cord-283382-t890r7xp	124	7	which	which	WDT
cord-283382-t890r7xp	124	8	have	have	VBP
cord-283382-t890r7xp	124	9	been	be	VBN
cord-283382-t890r7xp	124	10	implicated	implicate	VBN
cord-283382-t890r7xp	124	11	in	in	IN
cord-283382-t890r7xp	124	12	innate	innate	JJ
cord-283382-t890r7xp	124	13	immune	immune	JJ
cord-283382-t890r7xp	124	14	sensing	sensing	NN
cord-283382-t890r7xp	124	15	of	of	IN
cord-283382-t890r7xp	124	16	Ad	ad	NN
cord-283382-t890r7xp	124	17	vectors	vector	NNS
cord-283382-t890r7xp	124	18	and	and	CC
cord-283382-t890r7xp	124	19	the	the	DT
cord-283382-t890r7xp	124	20	caveats	caveat	NNS
cord-283382-t890r7xp	124	21	associated	associate	VBN
cord-283382-t890r7xp	124	22	,	,	,
cord-283382-t890r7xp	124	23	are	be	VBP
cord-283382-t890r7xp	124	24	described	describe	VBN
cord-283382-t890r7xp	124	25	below	below	RB
cord-283382-t890r7xp	124	26	.	.	.
cord-283382-t890r7xp	125	1	Recombinant	Recombinant	NNP
cord-283382-t890r7xp	125	2	Ad	ad	NN
cord-283382-t890r7xp	125	3	vectors	vector	NNS
cord-283382-t890r7xp	125	4	contain	contain	VBP
cord-283382-t890r7xp	125	5	PAMPs	pamp	NNS
cord-283382-t890r7xp	125	6	which	which	WDT
cord-283382-t890r7xp	125	7	can	can	MD
cord-283382-t890r7xp	125	8	be	be	VB
cord-283382-t890r7xp	125	9	sensed	sense	VBN
cord-283382-t890r7xp	125	10	by	by	IN
cord-283382-t890r7xp	125	11	cell	cell	NN
cord-283382-t890r7xp	125	12	-	-	HYPH
cord-283382-t890r7xp	125	13	surface	surface	NN
cord-283382-t890r7xp	125	14	or	or	CC
cord-283382-t890r7xp	125	15	endosomal	endosomal	NN
cord-283382-t890r7xp	125	16	pattern	pattern	NN
cord-283382-t890r7xp	125	17	recognition	recognition	NN
cord-283382-t890r7xp	125	18	receptors	receptor	NNS
cord-283382-t890r7xp	125	19	(	(	-LRB-
cord-283382-t890r7xp	125	20	PRRs	PRRs	NNP
cord-283382-t890r7xp	125	21	)	)	-RRB-
cord-283382-t890r7xp	125	22	such	such	JJ
cord-283382-t890r7xp	125	23	as	as	IN
cord-283382-t890r7xp	125	24	the	the	DT
cord-283382-t890r7xp	125	25	Toll	Toll	NNP
cord-283382-t890r7xp	125	26	-	-	HYPH
cord-283382-t890r7xp	125	27	like	like	JJ
cord-283382-t890r7xp	125	28	receptors	receptor	NNS
cord-283382-t890r7xp	125	29	(	(	-LRB-
cord-283382-t890r7xp	125	30	TLRs	TLRs	NNP
cord-283382-t890r7xp	125	31	)	)	-RRB-
cord-283382-t890r7xp	125	32	.	.	.
cord-283382-t890r7xp	126	1	TLRs	TLRs	NNP
cord-283382-t890r7xp	126	2	implicated	implicate	VBN
cord-283382-t890r7xp	126	3	in	in	IN
cord-283382-t890r7xp	126	4	the	the	DT
cord-283382-t890r7xp	126	5	sensing	sensing	NN
cord-283382-t890r7xp	126	6	of	of	IN
cord-283382-t890r7xp	126	7	Ad	ad	NN
cord-283382-t890r7xp	126	8	vectors	vector	NNS
cord-283382-t890r7xp	126	9	include	include	VBP
cord-283382-t890r7xp	126	10	TLR2	TLR2	NNP
cord-283382-t890r7xp	126	11	(	(	-LRB-
cord-283382-t890r7xp	126	12	113	113	CD
cord-283382-t890r7xp	126	13	)	)	-RRB-
cord-283382-t890r7xp	126	14	,	,	,
cord-283382-t890r7xp	126	15	TLR4	TLR4	NNP
cord-283382-t890r7xp	126	16	(	(	-LRB-
cord-283382-t890r7xp	126	17	114	114	CD
cord-283382-t890r7xp	126	18	)	)	-RRB-
cord-283382-t890r7xp	126	19	,	,	,
cord-283382-t890r7xp	126	20	and	and	CC
cord-283382-t890r7xp	126	21	endosomally	endosomally	RB
cord-283382-t890r7xp	126	22	located	locate	VBN
cord-283382-t890r7xp	126	23	TLR9	TLR9	NNP
cord-283382-t890r7xp	126	24	(	(	-LRB-
cord-283382-t890r7xp	126	25	61	61	CD
cord-283382-t890r7xp	126	26	,	,	,
cord-283382-t890r7xp	126	27	113	113	CD
cord-283382-t890r7xp	126	28	)	)	-RRB-
cord-283382-t890r7xp	126	29	,	,	,
cord-283382-t890r7xp	126	30	which	which	WDT
cord-283382-t890r7xp	126	31	can	can	MD
cord-283382-t890r7xp	126	32	trigger	trigger	VB
cord-283382-t890r7xp	126	33	the	the	DT
cord-283382-t890r7xp	126	34	down	down	JJ
cord-283382-t890r7xp	126	35	-	-	HYPH
cord-283382-t890r7xp	126	36	stream	stream	NN
cord-283382-t890r7xp	126	37	activation	activation	NN
cord-283382-t890r7xp	126	38	and	and	CC
cord-283382-t890r7xp	126	39	transcription	transcription	NN
cord-283382-t890r7xp	126	40	of	of	IN
cord-283382-t890r7xp	126	41	anti	anti	JJ
cord-283382-t890r7xp	126	42	-	-	JJ
cord-283382-t890r7xp	126	43	viral	viral	JJ
cord-283382-t890r7xp	126	44	genes	gene	NNS
cord-283382-t890r7xp	126	45	including	include	VBG
cord-283382-t890r7xp	126	46	NF	nf	NN
cord-283382-t890r7xp	126	47	-	-	HYPH
cord-283382-t890r7xp	126	48	κB	κB	NNP
cord-283382-t890r7xp	126	49	,	,	,
cord-283382-t890r7xp	126	50	mitogen	mitogen	NN
cord-283382-t890r7xp	126	51	-	-	HYPH
cord-283382-t890r7xp	126	52	activated	activate	VBN
cord-283382-t890r7xp	126	53	protein	protein	NN
cord-283382-t890r7xp	126	54	kinases	kinase	NNS
cord-283382-t890r7xp	126	55	(	(	-LRB-
cord-283382-t890r7xp	126	56	MAPK	MAPK	NNP
cord-283382-t890r7xp	126	57	)	)	-RRB-
cord-283382-t890r7xp	126	58	and	and	CC
cord-283382-t890r7xp	126	59	interferon	interferon	NN
cord-283382-t890r7xp	126	60	-	-	HYPH
cord-283382-t890r7xp	126	61	regulatory	regulatory	JJ
cord-283382-t890r7xp	126	62	factors	factor	NNS
cord-283382-t890r7xp	126	63	(	(	-LRB-
cord-283382-t890r7xp	126	64	IRFs	IRFs	NNP
cord-283382-t890r7xp	126	65	)	)	-RRB-
cord-283382-t890r7xp	126	66	.	.	.
cord-283382-t890r7xp	127	1	The	the	DT
cord-283382-t890r7xp	127	2	intracellular	intracellular	JJ
cord-283382-t890r7xp	127	3	adaptor	adaptor	NN
cord-283382-t890r7xp	127	4	protein	protein	NN
cord-283382-t890r7xp	127	5	MyD88	MyD88	NNS
cord-283382-t890r7xp	127	6	has	have	VBZ
cord-283382-t890r7xp	127	7	been	be	VBN
cord-283382-t890r7xp	127	8	reported	report	VBN
cord-283382-t890r7xp	127	9	to	to	TO
cord-283382-t890r7xp	127	10	play	play	VB
cord-283382-t890r7xp	127	11	a	a	DT
cord-283382-t890r7xp	127	12	major	major	JJ
cord-283382-t890r7xp	127	13	role	role	NN
cord-283382-t890r7xp	127	14	in	in	IN
cord-283382-t890r7xp	127	15	the	the	DT
cord-283382-t890r7xp	127	16	induction	induction	NN
cord-283382-t890r7xp	127	17	of	of	IN
cord-283382-t890r7xp	127	18	Ag	Ag	NNP
cord-283382-t890r7xp	127	19	-	-	HYPH
cord-283382-t890r7xp	127	20	specific	specific	JJ
cord-283382-t890r7xp	127	21	cellular	cellular	JJ
cord-283382-t890r7xp	127	22	immune	immune	JJ
cord-283382-t890r7xp	127	23	responses	response	NNS
cord-283382-t890r7xp	127	24	following	follow	VBG
cord-283382-t890r7xp	127	25	TLR	TLR	NNP
cord-283382-t890r7xp	127	26	-	-	HYPH
cord-283382-t890r7xp	127	27	mediated	mediate	VBN
cord-283382-t890r7xp	127	28	sensing	sensing	NN
cord-283382-t890r7xp	127	29	of	of	IN
cord-283382-t890r7xp	127	30	Ad	ad	NN
cord-283382-t890r7xp	127	31	vaccines	vaccine	NNS
cord-283382-t890r7xp	127	32	(	(	-LRB-
cord-283382-t890r7xp	127	33	109	109	CD
cord-283382-t890r7xp	127	34	,	,	,
cord-283382-t890r7xp	127	35	113	113	CD
cord-283382-t890r7xp	127	36	)	)	-RRB-
cord-283382-t890r7xp	127	37	.	.	.
cord-283382-t890r7xp	128	1	Importantly	importantly	RB
cord-283382-t890r7xp	128	2	,	,	,
cord-283382-t890r7xp	128	3	the	the	DT
cord-283382-t890r7xp	128	4	ability	ability	NN
cord-283382-t890r7xp	128	5	to	to	TO
cord-283382-t890r7xp	128	6	engage	engage	VB
cord-283382-t890r7xp	128	7	multiple	multiple	JJ
cord-283382-t890r7xp	128	8	MyD88-dependent	MyD88-dependent	NNP
cord-283382-t890r7xp	128	9	signaling	signal	VBG
cord-283382-t890r7xp	128	10	pathways	pathway	NNS
cord-283382-t890r7xp	128	11	simultaneously	simultaneously	RB
cord-283382-t890r7xp	128	12	,	,	,
cord-283382-t890r7xp	128	13	is	be	VBZ
cord-283382-t890r7xp	128	14	believed	believe	VBN
cord-283382-t890r7xp	128	15	to	to	TO
cord-283382-t890r7xp	128	16	contribute	contribute	VB
cord-283382-t890r7xp	128	17	to	to	IN
cord-283382-t890r7xp	128	18	the	the	DT
cord-283382-t890r7xp	128	19	robust	robust	JJ
cord-283382-t890r7xp	128	20	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	128	21	associated	associate	VBN
cord-283382-t890r7xp	128	22	with	with	IN
cord-283382-t890r7xp	128	23	Ad	ad	NN
cord-283382-t890r7xp	128	24	vaccines	vaccine	NNS
cord-283382-t890r7xp	128	25	.	.	.
cord-283382-t890r7xp	129	1	However	however	RB
cord-283382-t890r7xp	129	2	,	,	,
cord-283382-t890r7xp	129	3	their	-PRON-	PRP$
cord-283382-t890r7xp	129	4	immunological	immunological	JJ
cord-283382-t890r7xp	129	5	potency	potency	NN
cord-283382-t890r7xp	129	6	is	be	VBZ
cord-283382-t890r7xp	129	7	also	also	RB
cord-283382-t890r7xp	129	8	attributed	attribute	VBN
cord-283382-t890r7xp	129	9	to	to	IN
cord-283382-t890r7xp	129	10	the	the	DT
cord-283382-t890r7xp	129	11	fact	fact	NN
cord-283382-t890r7xp	129	12	that	that	IN
cord-283382-t890r7xp	129	13	innate	innate	JJ
cord-283382-t890r7xp	129	14	immune	immune	JJ
cord-283382-t890r7xp	129	15	activation	activation	NN
cord-283382-t890r7xp	129	16	by	by	IN
cord-283382-t890r7xp	129	17	recombinant	recombinant	JJ
cord-283382-t890r7xp	129	18	Ad	ad	NN
cord-283382-t890r7xp	129	19	vaccines	vaccine	NNS
cord-283382-t890r7xp	129	20	can	can	MD
cord-283382-t890r7xp	129	21	occur	occur	VB
cord-283382-t890r7xp	129	22	not	not	RB
cord-283382-t890r7xp	129	23	only	only	RB
cord-283382-t890r7xp	129	24	via	via	IN
cord-283382-t890r7xp	129	25	TLR	tlr	NN
cord-283382-t890r7xp	129	26	-	-	HYPH
cord-283382-t890r7xp	129	27	dependent	dependent	JJ
cord-283382-t890r7xp	129	28	mechanisms	mechanism	NNS
cord-283382-t890r7xp	129	29	,	,	,
cord-283382-t890r7xp	129	30	but	but	CC
cord-283382-t890r7xp	129	31	also	also	RB
cord-283382-t890r7xp	129	32	through	through	IN
cord-283382-t890r7xp	129	33	numerous	numerous	JJ
cord-283382-t890r7xp	129	34	TLR	tlr	NN
cord-283382-t890r7xp	129	35	-	-	HYPH
cord-283382-t890r7xp	129	36	independent	independent	JJ
cord-283382-t890r7xp	129	37	pathways	pathway	NNS
cord-283382-t890r7xp	129	38	(	(	-LRB-
cord-283382-t890r7xp	129	39	86	86	CD
cord-283382-t890r7xp	129	40	,	,	,
cord-283382-t890r7xp	129	41	109	109	CD
cord-283382-t890r7xp	129	42	,	,	,
cord-283382-t890r7xp	129	43	110	110	CD
cord-283382-t890r7xp	129	44	,	,	,
cord-283382-t890r7xp	129	45	113	113	CD
cord-283382-t890r7xp	129	46	,	,	,
cord-283382-t890r7xp	129	47	114	114	CD
cord-283382-t890r7xp	129	48	)	)	-RRB-
cord-283382-t890r7xp	129	49	.	.	.
cord-283382-t890r7xp	130	1	The	the	DT
cord-283382-t890r7xp	130	2	viral	viral	JJ
cord-283382-t890r7xp	130	3	DNA	dna	NN
cord-283382-t890r7xp	130	4	itself	-PRON-	PRP
cord-283382-t890r7xp	130	5	can	can	MD
cord-283382-t890r7xp	130	6	play	play	VB
cord-283382-t890r7xp	130	7	a	a	DT
cord-283382-t890r7xp	130	8	crucial	crucial	JJ
cord-283382-t890r7xp	130	9	role	role	NN
cord-283382-t890r7xp	130	10	in	in	IN
cord-283382-t890r7xp	130	11	triggering	trigger	VBG
cord-283382-t890r7xp	130	12	innate	innate	JJ
cord-283382-t890r7xp	130	13	immune	immune	JJ
cord-283382-t890r7xp	130	14	responses	response	NNS
cord-283382-t890r7xp	130	15	.	.	.
cord-283382-t890r7xp	131	1	In	in	IN
cord-283382-t890r7xp	131	2	recent	recent	JJ
cord-283382-t890r7xp	131	3	years	year	NNS
cord-283382-t890r7xp	131	4	it	-PRON-	PRP
cord-283382-t890r7xp	131	5	has	have	VBZ
cord-283382-t890r7xp	131	6	been	be	VBN
cord-283382-t890r7xp	131	7	demonstrated	demonstrate	VBN
cord-283382-t890r7xp	131	8	that	that	IN
cord-283382-t890r7xp	131	9	following	follow	VBG
cord-283382-t890r7xp	131	10	rupture	rupture	NN
cord-283382-t890r7xp	131	11	of	of	IN
cord-283382-t890r7xp	131	12	the	the	DT
cord-283382-t890r7xp	131	13	endosomal	endosomal	NNP
cord-283382-t890r7xp	131	14	membrane	membrane	NN
cord-283382-t890r7xp	131	15	,	,	,
cord-283382-t890r7xp	131	16	Ad	ad	NN
cord-283382-t890r7xp	131	17	viral	viral	JJ
cord-283382-t890r7xp	131	18	DNA	dna	NN
cord-283382-t890r7xp	131	19	can	can	MD
cord-283382-t890r7xp	131	20	also	also	RB
cord-283382-t890r7xp	131	21	be	be	VB
cord-283382-t890r7xp	131	22	sensed	sense	VBN
cord-283382-t890r7xp	131	23	by	by	IN
cord-283382-t890r7xp	131	24	the	the	DT
cord-283382-t890r7xp	131	25	cytosolic	cytosolic	JJ
cord-283382-t890r7xp	131	26	DNA	dna	NN
cord-283382-t890r7xp	131	27	sensor	sensor	NN
cord-283382-t890r7xp	131	28	cGAS	cgas	NN
cord-283382-t890r7xp	131	29	(	(	-LRB-
cord-283382-t890r7xp	131	30	115	115	CD
cord-283382-t890r7xp	131	31	,	,	,
cord-283382-t890r7xp	131	32	116	116	CD
cord-283382-t890r7xp	131	33	)	)	-RRB-
cord-283382-t890r7xp	131	34	.	.	.
cord-283382-t890r7xp	132	1	The	the	DT
cord-283382-t890r7xp	132	2	engagement	engagement	NN
cord-283382-t890r7xp	132	3	of	of	IN
cord-283382-t890r7xp	132	4	cGAS	cgas	NN
cord-283382-t890r7xp	132	5	triggers	trigger	VBZ
cord-283382-t890r7xp	132	6	a	a	DT
cord-283382-t890r7xp	132	7	signaling	signal	VBG
cord-283382-t890r7xp	132	8	cascade	cascade	NN
cord-283382-t890r7xp	132	9	involving	involve	VBG
cord-283382-t890r7xp	132	10	the	the	DT
cord-283382-t890r7xp	132	11	adaptor	adaptor	NN
cord-283382-t890r7xp	132	12	STING	sting	NN
cord-283382-t890r7xp	132	13	(	(	-LRB-
cord-283382-t890r7xp	132	14	117	117	CD
cord-283382-t890r7xp	132	15	)	)	-RRB-
cord-283382-t890r7xp	132	16	and	and	CC
cord-283382-t890r7xp	132	17	activation	activation	NN
cord-283382-t890r7xp	132	18	of	of	IN
cord-283382-t890r7xp	132	19	the	the	DT
cord-283382-t890r7xp	132	20	kinase	kinase	NN
cord-283382-t890r7xp	132	21	TBK1	TBK1	NNP
cord-283382-t890r7xp	132	22	,	,	,
cord-283382-t890r7xp	132	23	which	which	WDT
cord-283382-t890r7xp	132	24	initiate	initiate	VBP
cord-283382-t890r7xp	132	25	the	the	DT
cord-283382-t890r7xp	132	26	induction	induction	NN
cord-283382-t890r7xp	132	27	of	of	IN
cord-283382-t890r7xp	132	28	IRF3-responsive	IRF3-responsive	NNP
cord-283382-t890r7xp	132	29	genes	gene	NNS
cord-283382-t890r7xp	132	30	(	(	-LRB-
cord-283382-t890r7xp	132	31	115	115	CD
cord-283382-t890r7xp	132	32	)	)	-RRB-
cord-283382-t890r7xp	132	33	,	,	,
cord-283382-t890r7xp	132	34	such	such	JJ
cord-283382-t890r7xp	132	35	as	as	IN
cord-283382-t890r7xp	133	1	Type	type	NN
cord-283382-t890r7xp	133	2	I	-PRON-	PRP
cord-283382-t890r7xp	133	3	interferons	interferon	NNS
cord-283382-t890r7xp	133	4	(	(	-LRB-
cord-283382-t890r7xp	133	5	IFNs	IFNs	NNP
cord-283382-t890r7xp	133	6	)	)	-RRB-
cord-283382-t890r7xp	133	7	.	.	.
cord-283382-t890r7xp	134	1	It	-PRON-	PRP
cord-283382-t890r7xp	134	2	has	have	VBZ
cord-283382-t890r7xp	134	3	been	be	VBN
cord-283382-t890r7xp	134	4	shown	show	VBN
cord-283382-t890r7xp	134	5	that	that	IN
cord-283382-t890r7xp	134	6	the	the	DT
cord-283382-t890r7xp	134	7	absence	absence	NN
cord-283382-t890r7xp	134	8	of	of	IN
cord-283382-t890r7xp	134	9	cGAS	cgas	NN
cord-283382-t890r7xp	134	10	or	or	CC
cord-283382-t890r7xp	134	11	STING	sting	VB
cord-283382-t890r7xp	134	12	results	result	NNS
cord-283382-t890r7xp	134	13	in	in	IN
cord-283382-t890r7xp	134	14	reduced	reduce	VBN
cord-283382-t890r7xp	134	15	activation	activation	NN
cord-283382-t890r7xp	134	16	of	of	IN
cord-283382-t890r7xp	134	17	early	early	JJ
cord-283382-t890r7xp	134	18	innate	innate	JJ
cord-283382-t890r7xp	134	19	immunity	immunity	NN
cord-283382-t890r7xp	134	20	(	(	-LRB-
cord-283382-t890r7xp	134	21	i.e.	i.e.	FW
cord-283382-t890r7xp	134	22	,	,	,
cord-283382-t890r7xp	134	23	IFN	IFN	NNP
cord-283382-t890r7xp	134	24	-	-	HYPH
cord-283382-t890r7xp	134	25	β	β	NNP
cord-283382-t890r7xp	134	26	,	,	,
cord-283382-t890r7xp	134	27	cytokines	cytokine	NNS
cord-283382-t890r7xp	134	28	,	,	,
cord-283382-t890r7xp	134	29	chemokines	chemokine	NNS
cord-283382-t890r7xp	134	30	)	)	-RRB-
cord-283382-t890r7xp	134	31	but	but	CC
cord-283382-t890r7xp	134	32	does	do	VBZ
cord-283382-t890r7xp	134	33	not	not	RB
cord-283382-t890r7xp	134	34	impact	impact	VB
cord-283382-t890r7xp	134	35	adaptive	adaptive	JJ
cord-283382-t890r7xp	134	36	anti	anti	JJ
cord-283382-t890r7xp	134	37	-	-	JJ
cord-283382-t890r7xp	134	38	vector	vector	JJ
cord-283382-t890r7xp	134	39	immune	immune	JJ
cord-283382-t890r7xp	134	40	responses	response	NNS
cord-283382-t890r7xp	134	41	in	in	IN
cord-283382-t890r7xp	134	42	mice	mouse	NNS
cord-283382-t890r7xp	134	43	.	.	.
cord-283382-t890r7xp	135	1	However	however	RB
cord-283382-t890r7xp	135	2	,	,	,
cord-283382-t890r7xp	135	3	the	the	DT
cord-283382-t890r7xp	135	4	latter	latter	JJ
cord-283382-t890r7xp	135	5	studies	study	NNS
cord-283382-t890r7xp	135	6	were	be	VBD
cord-283382-t890r7xp	135	7	performed	perform	VBN
cord-283382-t890r7xp	135	8	in	in	IN
cord-283382-t890r7xp	135	9	the	the	DT
cord-283382-t890r7xp	135	10	context	context	NN
cord-283382-t890r7xp	135	11	of	of	IN
cord-283382-t890r7xp	135	12	i.v	i.v	NNP
cord-283382-t890r7xp	135	13	.	.	NNP
cord-283382-t890r7xp	135	14	delivery	delivery	NN
cord-283382-t890r7xp	135	15	and	and	CC
cord-283382-t890r7xp	135	16	anti	anti	JJ
cord-283382-t890r7xp	135	17	-	-	JJ
cord-283382-t890r7xp	135	18	vector	vector	NN
cord-283382-t890r7xp	135	19	,	,	,
cord-283382-t890r7xp	135	20	not	not	RB
cord-283382-t890r7xp	135	21	transgene	transgene	NN
cord-283382-t890r7xp	135	22	-	-	HYPH
cord-283382-t890r7xp	135	23	specific	specific	JJ
cord-283382-t890r7xp	135	24	immunity	immunity	NN
cord-283382-t890r7xp	135	25	(	(	-LRB-
cord-283382-t890r7xp	135	26	116	116	CD
cord-283382-t890r7xp	135	27	)	)	-RRB-
cord-283382-t890r7xp	135	28	,	,	,
cord-283382-t890r7xp	135	29	and	and	CC
cord-283382-t890r7xp	135	30	as	as	RB
cord-283382-t890r7xp	135	31	such	such	JJ
cord-283382-t890r7xp	135	32	,	,	,
cord-283382-t890r7xp	135	33	the	the	DT
cord-283382-t890r7xp	135	34	relative	relative	JJ
cord-283382-t890r7xp	135	35	importance	importance	NN
cord-283382-t890r7xp	135	36	of	of	IN
cord-283382-t890r7xp	135	37	DNA	dna	NN
cord-283382-t890r7xp	135	38	sensor	sensor	NN
cord-283382-t890r7xp	135	39	pathways	pathway	NNS
cord-283382-t890r7xp	135	40	in	in	IN
cord-283382-t890r7xp	135	41	the	the	DT
cord-283382-t890r7xp	135	42	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	135	43	of	of	IN
cord-283382-t890r7xp	135	44	Ads	ad	NNS
cord-283382-t890r7xp	135	45	as	as	IN
cord-283382-t890r7xp	135	46	vaccine	vaccine	NN
cord-283382-t890r7xp	135	47	vectors	vector	NNS
cord-283382-t890r7xp	135	48	is	be	VBZ
cord-283382-t890r7xp	135	49	less	less	RBR
cord-283382-t890r7xp	135	50	clear	clear	JJ
cord-283382-t890r7xp	135	51	.	.	.
cord-283382-t890r7xp	136	1	It	-PRON-	PRP
cord-283382-t890r7xp	136	2	has	have	VBZ
cord-283382-t890r7xp	136	3	recently	recently	RB
cord-283382-t890r7xp	136	4	has	have	VBZ
cord-283382-t890r7xp	136	5	been	be	VBN
cord-283382-t890r7xp	136	6	suggested	suggest	VBN
cord-283382-t890r7xp	136	7	that	that	IN
cord-283382-t890r7xp	136	8	Ag	Ag	NNP
cord-283382-t890r7xp	136	9	expression	expression	NN
cord-283382-t890r7xp	136	10	is	be	VBZ
cord-283382-t890r7xp	136	11	a	a	DT
cord-283382-t890r7xp	136	12	more	more	RBR
cord-283382-t890r7xp	136	13	crucial	crucial	JJ
cord-283382-t890r7xp	136	14	predictor	predictor	NN
cord-283382-t890r7xp	136	15	of	of	IN
cord-283382-t890r7xp	136	16	Ag	Ag	NNP
cord-283382-t890r7xp	136	17	-	-	HYPH
cord-283382-t890r7xp	136	18	specific	specific	JJ
cord-283382-t890r7xp	136	19	memory	memory	NN
cord-283382-t890r7xp	136	20	T	t	NN
cord-283382-t890r7xp	136	21	cells	cell	NNS
cord-283382-t890r7xp	136	22	(	(	-LRB-
cord-283382-t890r7xp	136	23	33	33	CD
cord-283382-t890r7xp	136	24	)	)	-RRB-
cord-283382-t890r7xp	136	25	,	,	,
cord-283382-t890r7xp	136	26	as	as	IN
cord-283382-t890r7xp	136	27	abrogation	abrogation	NN
cord-283382-t890r7xp	136	28	of	of	IN
cord-283382-t890r7xp	136	29	STING	sting	NN
cord-283382-t890r7xp	136	30	and	and	CC
cord-283382-t890r7xp	137	1	Type	type	NN
cord-283382-t890r7xp	137	2	I	-PRON-	PRP
cord-283382-t890r7xp	137	3	IFN	IFN	NNP
cord-283382-t890r7xp	137	4	responses	response	NNS
cord-283382-t890r7xp	137	5	during	during	IN
cord-283382-t890r7xp	137	6	Ad	ad	NN
cord-283382-t890r7xp	137	7	vaccination	vaccination	NN
cord-283382-t890r7xp	137	8	in	in	IN
cord-283382-t890r7xp	137	9	mice	mouse	NNS
cord-283382-t890r7xp	137	10	merely	merely	RB
cord-283382-t890r7xp	137	11	altered	alter	VBD
cord-283382-t890r7xp	137	12	the	the	DT
cord-283382-t890r7xp	137	13	early	early	JJ
cord-283382-t890r7xp	137	14	kinetics	kinetic	NNS
cord-283382-t890r7xp	137	15	of	of	IN
cord-283382-t890r7xp	137	16	CD8	CD8	NNP
cord-283382-t890r7xp	137	17	+	+	CC
cord-283382-t890r7xp	137	18	T	T	NNP
cord-283382-t890r7xp	137	19	cells	cell	NNS
cord-283382-t890r7xp	137	20	,	,	,
cord-283382-t890r7xp	137	21	but	but	CC
cord-283382-t890r7xp	137	22	did	do	VBD
cord-283382-t890r7xp	137	23	not	not	RB
cord-283382-t890r7xp	137	24	impair	impair	VB
cord-283382-t890r7xp	137	25	the	the	DT
cord-283382-t890r7xp	137	26	magnitude	magnitude	NN
cord-283382-t890r7xp	137	27	of	of	IN
cord-283382-t890r7xp	137	28	T	T	NNP
cord-283382-t890r7xp	137	29	cell	cell	NN
cord-283382-t890r7xp	137	30	memory	memory	NN
cord-283382-t890r7xp	137	31	responses	response	NNS
cord-283382-t890r7xp	137	32	(	(	-LRB-
cord-283382-t890r7xp	137	33	33	33	CD
cord-283382-t890r7xp	137	34	)	)	-RRB-
cord-283382-t890r7xp	137	35	.	.	.
cord-283382-t890r7xp	138	1	In	in	IN
cord-283382-t890r7xp	138	2	the	the	DT
cord-283382-t890r7xp	138	3	latter	latter	JJ
cord-283382-t890r7xp	138	4	study	study	NN
cord-283382-t890r7xp	138	5	,	,	,
cord-283382-t890r7xp	138	6	it	-PRON-	PRP
cord-283382-t890r7xp	138	7	was	be	VBD
cord-283382-t890r7xp	138	8	shown	show	VBN
cord-283382-t890r7xp	138	9	that	that	IN
cord-283382-t890r7xp	138	10	STING	STING	NNP
cord-283382-t890r7xp	138	11	could	could	MD
cord-283382-t890r7xp	138	12	act	act	VB
cord-283382-t890r7xp	138	13	as	as	IN
cord-283382-t890r7xp	138	14	a	a	DT
cord-283382-t890r7xp	138	15	dominant	dominant	JJ
cord-283382-t890r7xp	138	16	innate	innate	JJ
cord-283382-t890r7xp	138	17	PRR	PRR	NNP
cord-283382-t890r7xp	138	18	sensor	sensor	NN
cord-283382-t890r7xp	138	19	for	for	IN
cord-283382-t890r7xp	138	20	many	many	JJ
cord-283382-t890r7xp	138	21	Ad	ad	NN
cord-283382-t890r7xp	138	22	vectors	vector	NNS
cord-283382-t890r7xp	138	23	.	.	.
cord-283382-t890r7xp	139	1	Interestingly	interestingly	RB
cord-283382-t890r7xp	139	2	,	,	,
cord-283382-t890r7xp	139	3	abrogation	abrogation	NN
cord-283382-t890r7xp	139	4	of	of	IN
cord-283382-t890r7xp	139	5	STING	sting	NN
cord-283382-t890r7xp	139	6	accelerated	accelerate	VBD
cord-283382-t890r7xp	139	7	the	the	DT
cord-283382-t890r7xp	139	8	kinetics	kinetic	NNS
cord-283382-t890r7xp	139	9	of	of	IN
cord-283382-t890r7xp	139	10	Ag	Ag	NNP
cord-283382-t890r7xp	139	11	-	-	HYPH
cord-283382-t890r7xp	139	12	specific	specific	JJ
cord-283382-t890r7xp	139	13	T	T	NNP
cord-283382-t890r7xp	139	14	cell	cell	NN
cord-283382-t890r7xp	139	15	responses	response	NNS
cord-283382-t890r7xp	139	16	following	follow	VBG
cord-283382-t890r7xp	139	17	vaccination	vaccination	NN
cord-283382-t890r7xp	139	18	with	with	IN
cord-283382-t890r7xp	139	19	ChAdV-63	ChAdV-63	NNP
cord-283382-t890r7xp	139	20	,	,	,
cord-283382-t890r7xp	139	21	a	a	DT
cord-283382-t890r7xp	139	22	chimpanzee	chimpanzee	NN
cord-283382-t890r7xp	139	23	Ad	ad	NN
cord-283382-t890r7xp	139	24	vector	vector	NN
cord-283382-t890r7xp	139	25	,	,	,
cord-283382-t890r7xp	139	26	but	but	CC
cord-283382-t890r7xp	139	27	was	be	VBD
cord-283382-t890r7xp	139	28	dispensable	dispensable	JJ
cord-283382-t890r7xp	139	29	for	for	IN
cord-283382-t890r7xp	139	30	the	the	DT
cord-283382-t890r7xp	139	31	early	early	JJ
cord-283382-t890r7xp	139	32	induction	induction	NN
cord-283382-t890r7xp	139	33	of	of	IN
cord-283382-t890r7xp	139	34	CD8	CD8	NNP
cord-283382-t890r7xp	139	35	+	+	CC
cord-283382-t890r7xp	139	36	T	T	NNP
cord-283382-t890r7xp	139	37	cell	cell	NN
cord-283382-t890r7xp	139	38	responses	response	NNS
cord-283382-t890r7xp	139	39	for	for	IN
cord-283382-t890r7xp	139	40	Ad5	ad5	CD
cord-283382-t890r7xp	139	41	and	and	CC
cord-283382-t890r7xp	139	42	rare	rare	JJ
cord-283382-t890r7xp	139	43	species	specie	NNS
cord-283382-t890r7xp	140	1	HAdV	HAdV	NNP
cord-283382-t890r7xp	140	2	-	-	HYPH
cord-283382-t890r7xp	140	3	D28based	d28base	VBN
cord-283382-t890r7xp	140	4	vaccines	vaccine	NNS
cord-283382-t890r7xp	140	5	(	(	-LRB-
cord-283382-t890r7xp	140	6	33	33	CD
cord-283382-t890r7xp	140	7	)	)	-RRB-
cord-283382-t890r7xp	140	8	.	.	.
cord-283382-t890r7xp	141	1	This	this	DT
cord-283382-t890r7xp	141	2	supports	support	VBZ
cord-283382-t890r7xp	141	3	the	the	DT
cord-283382-t890r7xp	141	4	idea	idea	NN
cord-283382-t890r7xp	141	5	that	that	IN
cord-283382-t890r7xp	141	6	a	a	DT
cord-283382-t890r7xp	141	7	complex	complex	JJ
cord-283382-t890r7xp	141	8	interplay	interplay	NN
cord-283382-t890r7xp	141	9	between	between	IN
cord-283382-t890r7xp	141	10	multiple	multiple	JJ
cord-283382-t890r7xp	141	11	PRR	PRR	NNP
cord-283382-t890r7xp	141	12	-	-	HYPH
cord-283382-t890r7xp	141	13	mediated	mediate	VBN
cord-283382-t890r7xp	141	14	signaling	signal	VBG
cord-283382-t890r7xp	141	15	pathways	pathway	NNS
cord-283382-t890r7xp	141	16	exists	exist	VBZ
cord-283382-t890r7xp	141	17	,	,	,
cord-283382-t890r7xp	141	18	and	and	CC
cord-283382-t890r7xp	141	19	that	that	IN
cord-283382-t890r7xp	141	20	different	different	JJ
cord-283382-t890r7xp	141	21	Ad	ad	NN
cord-283382-t890r7xp	141	22	vectors	vector	NNS
cord-283382-t890r7xp	141	23	are	be	VBP
cord-283382-t890r7xp	141	24	differentially	differentially	RB
cord-283382-t890r7xp	141	25	impacted	impact	VBN
cord-283382-t890r7xp	141	26	by	by	IN
cord-283382-t890r7xp	141	27	these	these	DT
cord-283382-t890r7xp	141	28	pathways	pathway	NNS
cord-283382-t890r7xp	141	29	.	.	.
cord-283382-t890r7xp	142	1	Our	-PRON-	PRP$
cord-283382-t890r7xp	142	2	understanding	understanding	NN
cord-283382-t890r7xp	142	3	of	of	IN
cord-283382-t890r7xp	142	4	this	this	DT
cord-283382-t890r7xp	142	5	is	be	VBZ
cord-283382-t890r7xp	142	6	confounded	confound	VBN
cord-283382-t890r7xp	142	7	by	by	IN
cord-283382-t890r7xp	142	8	differences	difference	NNS
cord-283382-t890r7xp	142	9	in	in	IN
cord-283382-t890r7xp	142	10	receptor	receptor	NN
cord-283382-t890r7xp	142	11	usage	usage	NN
cord-283382-t890r7xp	142	12	,	,	,
cord-283382-t890r7xp	142	13	in	in	IN
cord-283382-t890r7xp	142	14	vivo	vivo	NN
cord-283382-t890r7xp	142	15	tropism	tropism	NN
cord-283382-t890r7xp	142	16	,	,	,
cord-283382-t890r7xp	142	17	engagement	engagement	NN
cord-283382-t890r7xp	142	18	of	of	IN
cord-283382-t890r7xp	142	19	PRRs	prr	NNS
cord-283382-t890r7xp	142	20	in	in	IN
cord-283382-t890r7xp	142	21	diverse	diverse	JJ
cord-283382-t890r7xp	142	22	hematopoietic	hematopoietic	JJ
cord-283382-t890r7xp	142	23	and	and	CC
cord-283382-t890r7xp	142	24	non	non	JJ
cord-283382-t890r7xp	142	25	-	-	JJ
cord-283382-t890r7xp	142	26	hematopoietic	hematopoietic	JJ
cord-283382-t890r7xp	142	27	cells	cell	NNS
cord-283382-t890r7xp	142	28	,	,	,
cord-283382-t890r7xp	142	29	and	and	CC
cord-283382-t890r7xp	142	30	by	by	IN
cord-283382-t890r7xp	142	31	differences	difference	NNS
cord-283382-t890r7xp	142	32	in	in	IN
cord-283382-t890r7xp	142	33	putative	putative	JJ
cord-283382-t890r7xp	142	34	PAMPs	pamp	NNS
cord-283382-t890r7xp	142	35	on	on	IN
cord-283382-t890r7xp	142	36	diverse	diverse	JJ
cord-283382-t890r7xp	142	37	Ad	ad	NN
cord-283382-t890r7xp	142	38	particles	particle	NNS
cord-283382-t890r7xp	142	39	.	.	.
cord-283382-t890r7xp	143	1	In	in	IN
cord-283382-t890r7xp	143	2	addition	addition	NN
cord-283382-t890r7xp	143	3	to	to	IN
cord-283382-t890r7xp	143	4	inducing	induce	VBG
cord-283382-t890r7xp	143	5	the	the	DT
cord-283382-t890r7xp	143	6	expression	expression	NN
cord-283382-t890r7xp	143	7	of	of	IN
cord-283382-t890r7xp	143	8	anti	anti	JJ
cord-283382-t890r7xp	143	9	-	-	JJ
cord-283382-t890r7xp	143	10	viral	viral	JJ
cord-283382-t890r7xp	143	11	genes	gene	NNS
cord-283382-t890r7xp	143	12	,	,	,
cord-283382-t890r7xp	143	13	infection	infection	NN
cord-283382-t890r7xp	143	14	with	with	IN
cord-283382-t890r7xp	143	15	Ad	ad	NN
cord-283382-t890r7xp	143	16	vectors	vector	NNS
cord-283382-t890r7xp	143	17	also	also	RB
cord-283382-t890r7xp	143	18	triggers	trigger	VBZ
cord-283382-t890r7xp	143	19	pro	pro	JJ
cord-283382-t890r7xp	143	20	-	-	JJ
cord-283382-t890r7xp	143	21	inflammatory	inflammatory	JJ
cord-283382-t890r7xp	143	22	responses	response	NNS
cord-283382-t890r7xp	143	23	through	through	IN
cord-283382-t890r7xp	143	24	cytosolic	cytosolic	JJ
cord-283382-t890r7xp	143	25	DNA	dna	NN
cord-283382-t890r7xp	143	26	-	-	HYPH
cord-283382-t890r7xp	143	27	sensing	sensing	NN
cord-283382-t890r7xp	143	28	mechanisms	mechanism	NNS
cord-283382-t890r7xp	143	29	which	which	WDT
cord-283382-t890r7xp	143	30	are	be	VBP
cord-283382-t890r7xp	143	31	independent	independent	JJ
cord-283382-t890r7xp	143	32	of	of	IN
cord-283382-t890r7xp	143	33	TLR9	TLR9	NNP
cord-283382-t890r7xp	143	34	and	and	CC
cord-283382-t890r7xp	143	35	IRFs	IRFs	NNP
cord-283382-t890r7xp	143	36	(	(	-LRB-
cord-283382-t890r7xp	143	37	111	111	CD
cord-283382-t890r7xp	143	38	)	)	-RRB-
cord-283382-t890r7xp	143	39	.	.	.
cord-283382-t890r7xp	144	1	In	in	IN
cord-283382-t890r7xp	144	2	macrophages	macrophage	NNS
cord-283382-t890r7xp	144	3	,	,	,
cord-283382-t890r7xp	144	4	recognition	recognition	NN
cord-283382-t890r7xp	144	5	of	of	IN
cord-283382-t890r7xp	144	6	Ad	ad	NN
cord-283382-t890r7xp	144	7	viral	viral	JJ
cord-283382-t890r7xp	144	8	DNA	dna	NN
cord-283382-t890r7xp	144	9	has	have	VBZ
cord-283382-t890r7xp	144	10	been	be	VBN
cord-283382-t890r7xp	144	11	shown	show	VBN
cord-283382-t890r7xp	144	12	to	to	TO
cord-283382-t890r7xp	144	13	be	be	VB
cord-283382-t890r7xp	144	14	mediated	mediate	VBN
cord-283382-t890r7xp	144	15	by	by	IN
cord-283382-t890r7xp	144	16	the	the	DT
cord-283382-t890r7xp	144	17	innate	innate	JJ
cord-283382-t890r7xp	144	18	cytosolic	cytosolic	JJ
cord-283382-t890r7xp	144	19	molecular	molecular	JJ
cord-283382-t890r7xp	144	20	complex	complex	NN
cord-283382-t890r7xp	144	21	,	,	,
cord-283382-t890r7xp	144	22	or	or	CC
cord-283382-t890r7xp	144	23	inflammasome	inflammasome	NNP
cord-283382-t890r7xp	144	24	,	,	,
cord-283382-t890r7xp	144	25	in	in	IN
cord-283382-t890r7xp	144	26	a	a	DT
cord-283382-t890r7xp	144	27	process	process	NN
cord-283382-t890r7xp	144	28	involving	involve	VBG
cord-283382-t890r7xp	144	29	NLRP3	nlrp3	XX
cord-283382-t890r7xp	144	30	and	and	CC
cord-283382-t890r7xp	144	31	(	(	-LRB-
cord-283382-t890r7xp	144	32	ASC	ASC	NNP
cord-283382-t890r7xp	144	33	)	)	-RRB-
cord-283382-t890r7xp	144	34	,	,	,
cord-283382-t890r7xp	144	35	which	which	WDT
cord-283382-t890r7xp	144	36	is	be	VBZ
cord-283382-t890r7xp	144	37	independent	independent	JJ
cord-283382-t890r7xp	144	38	of	of	IN
cord-283382-t890r7xp	144	39	viral	viral	JJ
cord-283382-t890r7xp	144	40	gene	gene	NN
cord-283382-t890r7xp	144	41	expression	expression	NN
cord-283382-t890r7xp	144	42	or	or	CC
cord-283382-t890r7xp	144	43	replication	replication	NN
cord-283382-t890r7xp	144	44	(	(	-LRB-
cord-283382-t890r7xp	144	45	117	117	CD
cord-283382-t890r7xp	144	46	)	)	-RRB-
cord-283382-t890r7xp	144	47	.	.	.
cord-283382-t890r7xp	145	1	The	the	DT
cord-283382-t890r7xp	145	2	multi	multi	JJ
cord-283382-t890r7xp	145	3	-	-	JJ
cord-283382-t890r7xp	145	4	protein	protein	JJ
cord-283382-t890r7xp	145	5	inflammasome	inflammasome	NN
cord-283382-t890r7xp	145	6	complex	complex	NN
cord-283382-t890r7xp	145	7	mediates	mediate	VBZ
cord-283382-t890r7xp	145	8	caspase-1	caspase-1	NNP
cord-283382-t890r7xp	145	9	activity	activity	NN
cord-283382-t890r7xp	145	10	,	,	,
cord-283382-t890r7xp	145	11	resulting	result	VBG
cord-283382-t890r7xp	145	12	in	in	IN
cord-283382-t890r7xp	145	13	the	the	DT
cord-283382-t890r7xp	145	14	processing	processing	NN
cord-283382-t890r7xp	145	15	of	of	IN
cord-283382-t890r7xp	145	16	pro	pro	JJ
cord-283382-t890r7xp	145	17	-	-	JJ
cord-283382-t890r7xp	145	18	interleukin-1β	interleukin-1β	JJ
cord-283382-t890r7xp	145	19	into	into	IN
cord-283382-t890r7xp	145	20	its	-PRON-	PRP$
cord-283382-t890r7xp	145	21	active	active	JJ
cord-283382-t890r7xp	145	22	and	and	CC
cord-283382-t890r7xp	145	23	secreted	secrete	VBN
cord-283382-t890r7xp	145	24	form	form	NN
cord-283382-t890r7xp	145	25	.	.	.
cord-283382-t890r7xp	146	1	IL-1β	IL-1β	NNP
cord-283382-t890r7xp	146	2	subsequently	subsequently	RB
cord-283382-t890r7xp	146	3	induces	induce	VBZ
cord-283382-t890r7xp	146	4	signaling	signal	VBG
cord-283382-t890r7xp	146	5	cascades	cascade	NNS
cord-283382-t890r7xp	146	6	of	of	IN
cord-283382-t890r7xp	146	7	proinflammatory	proinflammatory	JJ
cord-283382-t890r7xp	146	8	cytokines	cytokine	NNS
cord-283382-t890r7xp	146	9	and	and	CC
cord-283382-t890r7xp	146	10	chemokines	chemokine	NNS
cord-283382-t890r7xp	146	11	through	through	IN
cord-283382-t890r7xp	146	12	the	the	DT
cord-283382-t890r7xp	146	13	IL-1RI	IL-1RI	NNP
cord-283382-t890r7xp	146	14	both	both	DT
cord-283382-t890r7xp	146	15	in	in	IN
cord-283382-t890r7xp	146	16	vitro	vitro	FW
cord-283382-t890r7xp	146	17	and	and	CC
cord-283382-t890r7xp	146	18	in	in	IN
cord-283382-t890r7xp	146	19	vivo	vivo	NN
cord-283382-t890r7xp	146	20	in	in	IN
cord-283382-t890r7xp	146	21	response	response	NN
cord-283382-t890r7xp	146	22	to	to	IN
cord-283382-t890r7xp	146	23	Ad	ad	NN
cord-283382-t890r7xp	146	24	infection	infection	NN
cord-283382-t890r7xp	146	25	.	.	.
cord-283382-t890r7xp	147	1	However	however	RB
cord-283382-t890r7xp	147	2	,	,	,
cord-283382-t890r7xp	147	3	alternative	alternative	JJ
cord-283382-t890r7xp	147	4	and	and	CC
cord-283382-t890r7xp	147	5	contradictory	contradictory	JJ
cord-283382-t890r7xp	147	6	mechanisms	mechanism	NNS
cord-283382-t890r7xp	147	7	of	of	IN
cord-283382-t890r7xp	147	8	immune	immune	JJ
cord-283382-t890r7xp	147	9	activation	activation	NN
cord-283382-t890r7xp	147	10	in	in	IN
cord-283382-t890r7xp	147	11	macrophages	macrophage	NNS
cord-283382-t890r7xp	147	12	by	by	IN
cord-283382-t890r7xp	147	13	Ads	ad	NNS
cord-283382-t890r7xp	147	14	have	have	VBP
cord-283382-t890r7xp	147	15	also	also	RB
cord-283382-t890r7xp	147	16	been	be	VBN
cord-283382-t890r7xp	147	17	identified	identify	VBN
cord-283382-t890r7xp	147	18	which	which	WDT
cord-283382-t890r7xp	147	19	are	be	VBP
cord-283382-t890r7xp	147	20	independent	independent	JJ
cord-283382-t890r7xp	147	21	of	of	IN
cord-283382-t890r7xp	147	22	the	the	DT
cord-283382-t890r7xp	147	23	NLRP3	NLRP3	NNP
cord-283382-t890r7xp	147	24	inflammasome	inflammasome	NNP
cord-283382-t890r7xp	147	25	and	and	CC
cord-283382-t890r7xp	147	26	its	-PRON-	PRP$
cord-283382-t890r7xp	147	27	components	component	NNS
cord-283382-t890r7xp	147	28	.	.	.
cord-283382-t890r7xp	148	1	Di	Di	NNP
cord-283382-t890r7xp	148	2	Paolo	Paolo	NNP
cord-283382-t890r7xp	148	3	et	et	FW
cord-283382-t890r7xp	148	4	al	al	NNP
cord-283382-t890r7xp	148	5	.	.	.
cord-283382-t890r7xp	149	1	showed	show	VBD
cord-283382-t890r7xp	149	2	that	that	IN
cord-283382-t890r7xp	149	3	direct	direct	JJ
cord-283382-t890r7xp	149	4	interactions	interaction	NNS
cord-283382-t890r7xp	149	5	between	between	IN
cord-283382-t890r7xp	149	6	the	the	DT
cord-283382-t890r7xp	149	7	RGD	RGD	NNP
cord-283382-t890r7xp	149	8	motif	motif	NN
cord-283382-t890r7xp	149	9	within	within	IN
cord-283382-t890r7xp	149	10	the	the	DT
cord-283382-t890r7xp	149	11	penton	penton	NNP
cord-283382-t890r7xp	149	12	base	base	NN
cord-283382-t890r7xp	149	13	of	of	IN
cord-283382-t890r7xp	149	14	the	the	DT
cord-283382-t890r7xp	149	15	Ad	ad	NN
cord-283382-t890r7xp	149	16	virion	virion	NN
cord-283382-t890r7xp	149	17	and	and	CC
cord-283382-t890r7xp	149	18	the	the	DT
cord-283382-t890r7xp	149	19	β3	β3	NNP
cord-283382-t890r7xp	149	20	subunit	subunit	NN
cord-283382-t890r7xp	149	21	of	of	IN
cord-283382-t890r7xp	149	22	integrins	integrin	NNS
cord-283382-t890r7xp	149	23	on	on	IN
cord-283382-t890r7xp	149	24	the	the	DT
cord-283382-t890r7xp	149	25	surface	surface	NN
cord-283382-t890r7xp	149	26	of	of	IN
cord-283382-t890r7xp	149	27	macrophages	macrophage	NNS
cord-283382-t890r7xp	149	28	were	be	VBD
cord-283382-t890r7xp	149	29	responsible	responsible	JJ
cord-283382-t890r7xp	149	30	for	for	IN
cord-283382-t890r7xp	149	31	activating	activate	VBG
cord-283382-t890r7xp	149	32	IL-1α	il-1α	NN
cord-283382-t890r7xp	149	33	.	.	.
cord-283382-t890r7xp	150	1	The	the	DT
cord-283382-t890r7xp	150	2	authors	author	NNS
cord-283382-t890r7xp	150	3	also	also	RB
cord-283382-t890r7xp	150	4	proposed	propose	VBD
cord-283382-t890r7xp	150	5	that	that	IN
cord-283382-t890r7xp	150	6	IL-1α	IL-1α	NNP
cord-283382-t890r7xp	150	7	,	,	,
cord-283382-t890r7xp	150	8	not	not	RB
cord-283382-t890r7xp	150	9	IL-1β	IL-1β	NNP
cord-283382-t890r7xp	150	10	,	,	,
cord-283382-t890r7xp	150	11	was	be	VBD
cord-283382-t890r7xp	150	12	the	the	DT
cord-283382-t890r7xp	150	13	predominant	predominant	JJ
cord-283382-t890r7xp	150	14	activator	activator	NN
cord-283382-t890r7xp	150	15	of	of	IN
cord-283382-t890r7xp	150	16	innate	innate	JJ
cord-283382-t890r7xp	150	17	immune	immune	JJ
cord-283382-t890r7xp	150	18	responses	response	NNS
cord-283382-t890r7xp	150	19	to	to	IN
cord-283382-t890r7xp	150	20	Ad5	ad5	CD
cord-283382-t890r7xp	150	21	in	in	IN
cord-283382-t890r7xp	150	22	vivo	vivo	NNP
cord-283382-t890r7xp	150	23	(	(	-LRB-
cord-283382-t890r7xp	150	24	77	77	CD
cord-283382-t890r7xp	150	25	)	)	-RRB-
cord-283382-t890r7xp	150	26	.	.	.
cord-283382-t890r7xp	151	1	One	one	CD
cord-283382-t890r7xp	151	2	very	very	RB
cord-283382-t890r7xp	151	3	important	important	JJ
cord-283382-t890r7xp	151	4	caveat	caveat	NN
cord-283382-t890r7xp	151	5	which	which	WDT
cord-283382-t890r7xp	151	6	complicates	complicate	VBZ
cord-283382-t890r7xp	151	7	our	-PRON-	PRP$
cord-283382-t890r7xp	151	8	ability	ability	NN
cord-283382-t890r7xp	151	9	to	to	TO
cord-283382-t890r7xp	151	10	systematically	systematically	RB
cord-283382-t890r7xp	151	11	investigate	investigate	VB
cord-283382-t890r7xp	151	12	how	how	WRB
cord-283382-t890r7xp	151	13	innate	innate	JJ
cord-283382-t890r7xp	151	14	immune	immune	JJ
cord-283382-t890r7xp	151	15	responses	response	NNS
cord-283382-t890r7xp	151	16	contribute	contribute	VBP
cord-283382-t890r7xp	151	17	to	to	IN
cord-283382-t890r7xp	151	18	downstream	downstream	JJ
cord-283382-t890r7xp	151	19	adaptive	adaptive	JJ
cord-283382-t890r7xp	151	20	immunity	immunity	NN
cord-283382-t890r7xp	151	21	to	to	IN
cord-283382-t890r7xp	151	22	Ad	ad	NN
cord-283382-t890r7xp	151	23	vaccines	vaccine	NNS
cord-283382-t890r7xp	151	24	,	,	,
cord-283382-t890r7xp	151	25	is	be	VBZ
cord-283382-t890r7xp	151	26	that	that	IN
cord-283382-t890r7xp	151	27	many	many	JJ
cord-283382-t890r7xp	151	28	studies	study	NNS
cord-283382-t890r7xp	151	29	are	be	VBP
cord-283382-t890r7xp	151	30	performed	perform	VBN
cord-283382-t890r7xp	151	31	in	in	IN
cord-283382-t890r7xp	151	32	vitro	vitro	FW
cord-283382-t890r7xp	151	33	,	,	,
cord-283382-t890r7xp	151	34	using	use	VBG
cord-283382-t890r7xp	151	35	defined	define	VBN
cord-283382-t890r7xp	151	36	non	non	JJ
cord-283382-t890r7xp	151	37	-	-	JJ
cord-283382-t890r7xp	151	38	immune	immune	JJ
cord-283382-t890r7xp	151	39	epithelial	epithelial	JJ
cord-283382-t890r7xp	151	40	/	/	SYM
cord-283382-t890r7xp	151	41	endothelial	endothelial	JJ
cord-283382-t890r7xp	151	42	cells	cell	NNS
cord-283382-t890r7xp	151	43	or	or	CC
cord-283382-t890r7xp	151	44	cultured	cultured	JJ
cord-283382-t890r7xp	151	45	immune	immune	JJ
cord-283382-t890r7xp	151	46	cells	cell	NNS
cord-283382-t890r7xp	151	47	including	include	VBG
cord-283382-t890r7xp	151	48	macrophages	macrophage	NNS
cord-283382-t890r7xp	151	49	or	or	CC
cord-283382-t890r7xp	151	50	dendritic	dendritic	JJ
cord-283382-t890r7xp	151	51	cells	cell	NNS
cord-283382-t890r7xp	151	52	(	(	-LRB-
cord-283382-t890r7xp	151	53	110	110	CD
cord-283382-t890r7xp	151	54	,	,	,
cord-283382-t890r7xp	151	55	115	115	CD
cord-283382-t890r7xp	151	56	,	,	,
cord-283382-t890r7xp	151	57	118	118	CD
cord-283382-t890r7xp	151	58	)	)	-RRB-
cord-283382-t890r7xp	151	59	.	.	.
cord-283382-t890r7xp	152	1	These	these	DT
cord-283382-t890r7xp	152	2	cell	cell	NN
cord-283382-t890r7xp	152	3	type	type	NN
cord-283382-t890r7xp	152	4	-	-	HYPH
cord-283382-t890r7xp	152	5	specific	specific	JJ
cord-283382-t890r7xp	152	6	findings	finding	NNS
cord-283382-t890r7xp	152	7	often	often	RB
cord-283382-t890r7xp	152	8	contradict	contradict	VBP
cord-283382-t890r7xp	152	9	subsequent	subsequent	JJ
cord-283382-t890r7xp	152	10	in	in	IN
cord-283382-t890r7xp	152	11	vivo	vivo	NN
cord-283382-t890r7xp	152	12	studies	study	NNS
cord-283382-t890r7xp	152	13	using	use	VBG
cord-283382-t890r7xp	152	14	transgenic	transgenic	JJ
cord-283382-t890r7xp	152	15	mice	mouse	NNS
cord-283382-t890r7xp	152	16	in	in	IN
cord-283382-t890r7xp	152	17	which	which	WDT
cord-283382-t890r7xp	152	18	these	these	DT
cord-283382-t890r7xp	152	19	"	"	``
cord-283382-t890r7xp	152	20	critical	critical	JJ
cord-283382-t890r7xp	152	21	"	"	''
cord-283382-t890r7xp	152	22	mediators	mediator	NNS
cord-283382-t890r7xp	152	23	of	of	IN
cord-283382-t890r7xp	152	24	innate	innate	JJ
cord-283382-t890r7xp	152	25	immunity	immunity	NN
cord-283382-t890r7xp	152	26	are	be	VBP
cord-283382-t890r7xp	152	27	knocked	knock	VBN
cord-283382-t890r7xp	152	28	-	-	HYPH
cord-283382-t890r7xp	152	29	out	out	NN
cord-283382-t890r7xp	152	30	(	(	-LRB-
cord-283382-t890r7xp	152	31	77	77	CD
cord-283382-t890r7xp	152	32	,	,	,
cord-283382-t890r7xp	152	33	116	116	CD
cord-283382-t890r7xp	152	34	)	)	-RRB-
cord-283382-t890r7xp	152	35	.	.	.
cord-283382-t890r7xp	153	1	For	for	IN
cord-283382-t890r7xp	153	2	example	example	NN
cord-283382-t890r7xp	153	3	,	,	,
cord-283382-t890r7xp	153	4	despite	despite	IN
cord-283382-t890r7xp	153	5	numerous	numerous	JJ
cord-283382-t890r7xp	153	6	reports	report	NNS
cord-283382-t890r7xp	153	7	describing	describe	VBG
cord-283382-t890r7xp	153	8	an	an	DT
cord-283382-t890r7xp	153	9	important	important	JJ
cord-283382-t890r7xp	153	10	role	role	NN
cord-283382-t890r7xp	153	11	for	for	IN
cord-283382-t890r7xp	153	12	TLR9	TLR9	NNP
cord-283382-t890r7xp	153	13	in	in	IN
cord-283382-t890r7xp	153	14	vitro	vitro	FW
cord-283382-t890r7xp	153	15	,	,	,
cord-283382-t890r7xp	153	16	comparisons	comparison	NNS
cord-283382-t890r7xp	153	17	of	of	IN
cord-283382-t890r7xp	153	18	wildtype	wildtype	NN
cord-283382-t890r7xp	153	19	and	and	CC
cord-283382-t890r7xp	153	20	TLR9	TLR9	NNP
cord-283382-t890r7xp	153	21	−/−	−/−	NNP
cord-283382-t890r7xp	153	22	mice	mouse	NNS
cord-283382-t890r7xp	153	23	have	have	VBP
cord-283382-t890r7xp	153	24	demonstrated	demonstrate	VBN
cord-283382-t890r7xp	153	25	that	that	IN
cord-283382-t890r7xp	153	26	the	the	DT
cord-283382-t890r7xp	153	27	impact	impact	NN
cord-283382-t890r7xp	153	28	of	of	IN
cord-283382-t890r7xp	153	29	TLR9	TLR9	NNP
cord-283382-t890r7xp	153	30	in	in	IN
cord-283382-t890r7xp	153	31	innate	innate	JJ
cord-283382-t890r7xp	153	32	immune	immune	JJ
cord-283382-t890r7xp	153	33	sensing	sensing	NN
cord-283382-t890r7xp	153	34	of	of	IN
cord-283382-t890r7xp	153	35	Ad	ad	NN
cord-283382-t890r7xp	153	36	particles	particle	NNS
cord-283382-t890r7xp	153	37	in	in	IN
cord-283382-t890r7xp	153	38	vivo	vivo	NN
cord-283382-t890r7xp	153	39	is	be	VBZ
cord-283382-t890r7xp	153	40	minimal	minimal	JJ
cord-283382-t890r7xp	153	41	(	(	-LRB-
cord-283382-t890r7xp	153	42	77	77	CD
cord-283382-t890r7xp	153	43	)	)	-RRB-
cord-283382-t890r7xp	153	44	,	,	,
cord-283382-t890r7xp	153	45	at	at	IN
cord-283382-t890r7xp	153	46	least	least	JJS
cord-283382-t890r7xp	153	47	for	for	IN
cord-283382-t890r7xp	153	48	i.v	i.v	NNP
cord-283382-t890r7xp	153	49	.	.	NNP
cord-283382-t890r7xp	153	50	administration	administration	NN
cord-283382-t890r7xp	153	51	of	of	IN
cord-283382-t890r7xp	153	52	Ad5	Ad5	NNP
cord-283382-t890r7xp	153	53	.	.	.
cord-283382-t890r7xp	154	1	Similarly	similarly	RB
cord-283382-t890r7xp	154	2	,	,	,
cord-283382-t890r7xp	154	3	although	although	IN
cord-283382-t890r7xp	154	4	cGAS	cgas	NN
cord-283382-t890r7xp	154	5	or	or	CC
cord-283382-t890r7xp	154	6	STING	sting	NN
cord-283382-t890r7xp	154	7	were	be	VBD
cord-283382-t890r7xp	154	8	shown	show	VBN
cord-283382-t890r7xp	154	9	to	to	TO
cord-283382-t890r7xp	154	10	be	be	VB
cord-283382-t890r7xp	154	11	pivotal	pivotal	JJ
cord-283382-t890r7xp	154	12	in	in	IN
cord-283382-t890r7xp	154	13	early	early	JJ
cord-283382-t890r7xp	154	14	immune	immune	JJ
cord-283382-t890r7xp	154	15	sensing	sensing	NN
cord-283382-t890r7xp	154	16	of	of	IN
cord-283382-t890r7xp	154	17	Ad	ad	NN
cord-283382-t890r7xp	154	18	in	in	IN
cord-283382-t890r7xp	154	19	vivo	vivo	NN
cord-283382-t890r7xp	154	20	,	,	,
cord-283382-t890r7xp	154	21	studies	study	NNS
cord-283382-t890r7xp	154	22	using	use	VBG
cord-283382-t890r7xp	154	23	cGAS	cgas	JJ
cord-283382-t890r7xp	154	24	−/−	−/−	NNP
cord-283382-t890r7xp	154	25	or	or	CC
cord-283382-t890r7xp	154	26	STING	sting	VB
cord-283382-t890r7xp	154	27	−/−	−/−	NNP
cord-283382-t890r7xp	154	28	mice	mouse	NNS
cord-283382-t890r7xp	154	29	showed	show	VBD
cord-283382-t890r7xp	154	30	that	that	IN
cord-283382-t890r7xp	154	31	these	these	DT
cord-283382-t890r7xp	154	32	molecular	molecular	JJ
cord-283382-t890r7xp	154	33	effectors	effector	NNS
cord-283382-t890r7xp	154	34	have	have	VBP
cord-283382-t890r7xp	154	35	little	little	JJ
cord-283382-t890r7xp	154	36	impact	impact	NN
cord-283382-t890r7xp	154	37	on	on	IN
cord-283382-t890r7xp	154	38	subsequent	subsequent	JJ
cord-283382-t890r7xp	154	39	adaptive	adaptive	JJ
cord-283382-t890r7xp	154	40	immunity	immunity	NN
cord-283382-t890r7xp	154	41	and	and	CC
cord-283382-t890r7xp	154	42	antibody	antibody	NN
cord-283382-t890r7xp	154	43	production	production	NN
cord-283382-t890r7xp	154	44	(	(	-LRB-
cord-283382-t890r7xp	154	45	116	116	CD
cord-283382-t890r7xp	154	46	)	)	-RRB-
cord-283382-t890r7xp	154	47	.	.	.
cord-283382-t890r7xp	155	1	These	these	DT
cord-283382-t890r7xp	155	2	discrepancies	discrepancy	NNS
cord-283382-t890r7xp	155	3	are	be	VBP
cord-283382-t890r7xp	155	4	obviously	obviously	RB
cord-283382-t890r7xp	155	5	further	further	RB
cord-283382-t890r7xp	155	6	complicated	complicate	VBN
cord-283382-t890r7xp	155	7	by	by	IN
cord-283382-t890r7xp	155	8	the	the	DT
cord-283382-t890r7xp	155	9	known	know	VBN
cord-283382-t890r7xp	155	10	capacity	capacity	NN
cord-283382-t890r7xp	155	11	of	of	IN
cord-283382-t890r7xp	155	12	Ad	ad	NN
cord-283382-t890r7xp	155	13	vectors	vector	NNS
cord-283382-t890r7xp	155	14	to	to	TO
cord-283382-t890r7xp	155	15	engage	engage	VB
cord-283382-t890r7xp	155	16	multiple	multiple	JJ
cord-283382-t890r7xp	155	17	innate	innate	JJ
cord-283382-t890r7xp	155	18	signaling	signal	VBG
cord-283382-t890r7xp	155	19	pathways	pathway	NNS
cord-283382-t890r7xp	155	20	simultaneously	simultaneously	RB
cord-283382-t890r7xp	155	21	,	,	,
cord-283382-t890r7xp	155	22	rendering	render	VBG
cord-283382-t890r7xp	155	23	individual	individual	JJ
cord-283382-t890r7xp	155	24	pathways	pathway	NNS
cord-283382-t890r7xp	155	25	at	at	IN
cord-283382-t890r7xp	155	26	least	least	JJS
cord-283382-t890r7xp	155	27	partially	partially	RB
cord-283382-t890r7xp	155	28	redundant	redundant	JJ
cord-283382-t890r7xp	155	29	in	in	IN
cord-283382-t890r7xp	155	30	vivo	vivo	NNP
cord-283382-t890r7xp	155	31	(	(	-LRB-
cord-283382-t890r7xp	155	32	110	110	CD
cord-283382-t890r7xp	155	33	)	)	-RRB-
cord-283382-t890r7xp	155	34	.	.	.
cord-283382-t890r7xp	156	1	In	in	IN
cord-283382-t890r7xp	156	2	addition	addition	NN
cord-283382-t890r7xp	156	3	to	to	IN
cord-283382-t890r7xp	156	4	this	this	DT
cord-283382-t890r7xp	156	5	,	,	,
cord-283382-t890r7xp	156	6	differences	difference	NNS
cord-283382-t890r7xp	156	7	in	in	IN
cord-283382-t890r7xp	156	8	the	the	DT
cord-283382-t890r7xp	156	9	route	route	NN
cord-283382-t890r7xp	156	10	of	of	IN
cord-283382-t890r7xp	156	11	Ad	ad	NN
cord-283382-t890r7xp	156	12	vector	vector	NN
cord-283382-t890r7xp	156	13	delivery	delivery	NN
cord-283382-t890r7xp	156	14	(	(	-LRB-
cord-283382-t890r7xp	156	15	i.e.	i.e.	FW
cord-283382-t890r7xp	156	16	,	,	,
cord-283382-t890r7xp	156	17	i.m	i.m	NNP
cord-283382-t890r7xp	156	18	,	,	,
cord-283382-t890r7xp	156	19	i.v	i.v	NNP
cord-283382-t890r7xp	156	20	.	.	NNP
cord-283382-t890r7xp	156	21	,	,	,
cord-283382-t890r7xp	156	22	or	or	CC
cord-283382-t890r7xp	156	23	intranasal	intranasal	NN
cord-283382-t890r7xp	156	24	)	)	-RRB-
cord-283382-t890r7xp	156	25	and	and	CC
cord-283382-t890r7xp	156	26	access	access	NN
cord-283382-t890r7xp	156	27	to	to	IN
cord-283382-t890r7xp	156	28	different	different	JJ
cord-283382-t890r7xp	156	29	cell	cell	NN
cord-283382-t890r7xp	156	30	types	type	NNS
cord-283382-t890r7xp	156	31	,	,	,
cord-283382-t890r7xp	156	32	the	the	DT
cord-283382-t890r7xp	156	33	multiplicity	multiplicity	NN
cord-283382-t890r7xp	156	34	of	of	IN
cord-283382-t890r7xp	156	35	infection	infection	NN
cord-283382-t890r7xp	156	36	(	(	-LRB-
cord-283382-t890r7xp	156	37	MOI	MOI	NNP
cord-283382-t890r7xp	156	38	)	)	-RRB-
cord-283382-t890r7xp	156	39	or	or	CC
cord-283382-t890r7xp	156	40	injected	inject	VBN
cord-283382-t890r7xp	156	41	dose	dose	NN
cord-283382-t890r7xp	156	42	,	,	,
cord-283382-t890r7xp	156	43	the	the	DT
cord-283382-t890r7xp	156	44	timing	timing	NN
cord-283382-t890r7xp	156	45	or	or	CC
cord-283382-t890r7xp	156	46	method	method	NN
cord-283382-t890r7xp	156	47	of	of	IN
cord-283382-t890r7xp	156	48	analysis	analysis	NN
cord-283382-t890r7xp	156	49	reported	report	VBN
cord-283382-t890r7xp	156	50	in	in	IN
cord-283382-t890r7xp	156	51	published	publish	VBN
cord-283382-t890r7xp	156	52	work	work	NN
cord-283382-t890r7xp	156	53	and	and	CC
cord-283382-t890r7xp	156	54	the	the	DT
cord-283382-t890r7xp	156	55	use	use	NN
cord-283382-t890r7xp	156	56	of	of	IN
cord-283382-t890r7xp	156	57	non	non	JJ
cord-283382-t890r7xp	156	58	-	-	JJ
cord-283382-t890r7xp	156	59	human	human	JJ
cord-283382-t890r7xp	156	60	or	or	CC
cord-283382-t890r7xp	156	61	rare	rare	JJ
cord-283382-t890r7xp	156	62	species	specie	NNS
cord-283382-t890r7xp	156	63	Ad	ad	NN
cord-283382-t890r7xp	156	64	vectors	vector	NNS
cord-283382-t890r7xp	156	65	with	with	IN
cord-283382-t890r7xp	156	66	differential	differential	JJ
cord-283382-t890r7xp	156	67	receptor	receptor	NN
cord-283382-t890r7xp	156	68	usage	usage	NN
cord-283382-t890r7xp	156	69	,	,	,
cord-283382-t890r7xp	156	70	also	also	RB
cord-283382-t890r7xp	156	71	limits	limit	VBZ
cord-283382-t890r7xp	156	72	our	-PRON-	PRP$
cord-283382-t890r7xp	156	73	ability	ability	NN
cord-283382-t890r7xp	156	74	to	to	TO
cord-283382-t890r7xp	156	75	fully	fully	RB
cord-283382-t890r7xp	156	76	dissect	dissect	VB
cord-283382-t890r7xp	156	77	out	out	RP
cord-283382-t890r7xp	156	78	the	the	DT
cord-283382-t890r7xp	156	79	key	key	JJ
cord-283382-t890r7xp	156	80	contributing	contribute	VBG
cord-283382-t890r7xp	156	81	pathways	pathway	NNS
cord-283382-t890r7xp	156	82	(	(	-LRB-
cord-283382-t890r7xp	156	83	118	118	CD
cord-283382-t890r7xp	156	84	,	,	,
cord-283382-t890r7xp	156	85	119	119	CD
cord-283382-t890r7xp	156	86	)	)	-RRB-
cord-283382-t890r7xp	156	87	.	.	.
cord-283382-t890r7xp	157	1	Collectively	collectively	RB
cord-283382-t890r7xp	157	2	,	,	,
cord-283382-t890r7xp	157	3	these	these	DT
cord-283382-t890r7xp	157	4	factors	factor	NNS
cord-283382-t890r7xp	157	5	highlight	highlight	VBP
cord-283382-t890r7xp	157	6	the	the	DT
cord-283382-t890r7xp	157	7	many	many	JJ
cord-283382-t890r7xp	157	8	challenges	challenge	NNS
cord-283382-t890r7xp	157	9	facing	face	VBG
cord-283382-t890r7xp	157	10	the	the	DT
cord-283382-t890r7xp	157	11	field	field	NN
cord-283382-t890r7xp	157	12	and	and	CC
cord-283382-t890r7xp	157	13	explain	explain	VB
cord-283382-t890r7xp	157	14	why	why	WRB
cord-283382-t890r7xp	157	15	we	-PRON-	PRP
cord-283382-t890r7xp	157	16	currently	currently	RB
cord-283382-t890r7xp	157	17	lack	lack	VBP
cord-283382-t890r7xp	157	18	consensus	consensus	NN
cord-283382-t890r7xp	157	19	on	on	IN
cord-283382-t890r7xp	157	20	precisely	precisely	RB
cord-283382-t890r7xp	157	21	which	which	WDT
cord-283382-t890r7xp	157	22	innate	innate	VBP
cord-283382-t890r7xp	157	23	signaling	signal	VBG
cord-283382-t890r7xp	157	24	pathways	pathway	NNS
cord-283382-t890r7xp	157	25	could	could	MD
cord-283382-t890r7xp	157	26	contribute	contribute	VB
cord-283382-t890r7xp	157	27	to	to	IN
cord-283382-t890r7xp	157	28	protective	protective	JJ
cord-283382-t890r7xp	157	29	immunity	immunity	NN
cord-283382-t890r7xp	157	30	following	follow	VBG
cord-283382-t890r7xp	157	31	vaccination	vaccination	NN
cord-283382-t890r7xp	157	32	with	with	IN
cord-283382-t890r7xp	157	33	diverse	diverse	JJ
cord-283382-t890r7xp	157	34	Ad	ad	NN
cord-283382-t890r7xp	157	35	vectors	vector	NNS
cord-283382-t890r7xp	157	36	.	.	.
cord-283382-t890r7xp	158	1	It	-PRON-	PRP
cord-283382-t890r7xp	158	2	has	have	VBZ
cord-283382-t890r7xp	158	3	been	be	VBN
cord-283382-t890r7xp	158	4	proposed	propose	VBN
cord-283382-t890r7xp	158	5	that	that	IN
cord-283382-t890r7xp	158	6	minimal	minimal	JJ
cord-283382-t890r7xp	158	7	induction	induction	NN
cord-283382-t890r7xp	158	8	of	of	IN
cord-283382-t890r7xp	158	9	Type	type	NN
cord-283382-t890r7xp	158	10	I	I	NNP
cord-283382-t890r7xp	158	11	IFNs	ifns	NN
cord-283382-t890r7xp	158	12	(	(	-LRB-
cord-283382-t890r7xp	158	13	44	44	CD
cord-283382-t890r7xp	158	14	,	,	,
cord-283382-t890r7xp	158	15	102	102	CD
cord-283382-t890r7xp	158	16	,	,	,
cord-283382-t890r7xp	158	17	120	120	CD
cord-283382-t890r7xp	158	18	)	)	-RRB-
cord-283382-t890r7xp	158	19	,	,	,
cord-283382-t890r7xp	158	20	in	in	IN
cord-283382-t890r7xp	158	21	conjunction	conjunction	NN
cord-283382-t890r7xp	158	22	with	with	IN
cord-283382-t890r7xp	158	23	sustained	sustained	JJ
cord-283382-t890r7xp	158	24	transgene	transgene	JJ
cord-283382-t890r7xp	158	25	expression	expression	NN
cord-283382-t890r7xp	158	26	(	(	-LRB-
cord-283382-t890r7xp	158	27	33	33	CD
cord-283382-t890r7xp	158	28	)	)	-RRB-
cord-283382-t890r7xp	158	29	,	,	,
cord-283382-t890r7xp	158	30	are	be	VBP
cord-283382-t890r7xp	158	31	hallmarks	hallmark	VBN
cord-283382-t890r7xp	158	32	of	of	IN
cord-283382-t890r7xp	158	33	potently	potently	RB
cord-283382-t890r7xp	158	34	immunogenic	immunogenic	JJ
cord-283382-t890r7xp	158	35	Ad	ad	NN
cord-283382-t890r7xp	158	36	vaccine	vaccine	NN
cord-283382-t890r7xp	158	37	vectors	vector	NNS
cord-283382-t890r7xp	158	38	in	in	IN
cord-283382-t890r7xp	158	39	vivo	vivo	NN
cord-283382-t890r7xp	158	40	.	.	.
cord-283382-t890r7xp	159	1	Excessive	excessive	JJ
cord-283382-t890r7xp	159	2	stimulation	stimulation	NN
cord-283382-t890r7xp	159	3	of	of	IN
cord-283382-t890r7xp	159	4	Type	type	NN
cord-283382-t890r7xp	159	5	I	-PRON-	PRP
cord-283382-t890r7xp	159	6	IFN	IFN	NNP
cord-283382-t890r7xp	159	7	pathways	pathway	NNS
cord-283382-t890r7xp	159	8	at	at	IN
cord-283382-t890r7xp	159	9	early	early	JJ
cord-283382-t890r7xp	159	10	time	time	NN
cord-283382-t890r7xp	159	11	-	-	HYPH
cord-283382-t890r7xp	159	12	points	point	NNS
cord-283382-t890r7xp	159	13	following	follow	VBG
cord-283382-t890r7xp	159	14	immunization	immunization	NN
cord-283382-t890r7xp	159	15	has	have	VBZ
cord-283382-t890r7xp	159	16	been	be	VBN
cord-283382-t890r7xp	159	17	shown	show	VBN
cord-283382-t890r7xp	159	18	to	to	TO
cord-283382-t890r7xp	159	19	lead	lead	VB
cord-283382-t890r7xp	159	20	to	to	IN
cord-283382-t890r7xp	159	21	decreased	decrease	VBN
cord-283382-t890r7xp	159	22	transgene	transgene	JJ
cord-283382-t890r7xp	159	23	expression	expression	NN
cord-283382-t890r7xp	159	24	and	and	CC
cord-283382-t890r7xp	159	25	subsequently	subsequently	RB
cord-283382-t890r7xp	159	26	reduced	reduce	VBD
cord-283382-t890r7xp	159	27	Ag	Ag	NNP
cord-283382-t890r7xp	159	28	-	-	HYPH
cord-283382-t890r7xp	159	29	specific	specific	JJ
cord-283382-t890r7xp	159	30	antibody	antibody	NN
cord-283382-t890r7xp	159	31	(	(	-LRB-
cord-283382-t890r7xp	159	32	Ab	ab	NN
cord-283382-t890r7xp	159	33	)	)	-RRB-
cord-283382-t890r7xp	159	34	responses	response	NNS
cord-283382-t890r7xp	159	35	,	,	,
cord-283382-t890r7xp	159	36	following	follow	VBG
cord-283382-t890r7xp	159	37	immunization	immunization	NN
cord-283382-t890r7xp	159	38	with	with	IN
cord-283382-t890r7xp	159	39	a	a	DT
cord-283382-t890r7xp	159	40	chimpanzee	chimpanzee	NN
cord-283382-t890r7xp	159	41	Ad	ad	NN
cord-283382-t890r7xp	159	42	vector	vector	NN
cord-283382-t890r7xp	159	43	,	,	,
cord-283382-t890r7xp	159	44	ChAdV-68	chadv-68	NN
cord-283382-t890r7xp	159	45	(	(	-LRB-
cord-283382-t890r7xp	159	46	120	120	CD
cord-283382-t890r7xp	159	47	)	)	-RRB-
cord-283382-t890r7xp	159	48	.	.	.
cord-283382-t890r7xp	160	1	The	the	DT
cord-283382-t890r7xp	160	2	authors	author	NNS
cord-283382-t890r7xp	160	3	demonstrated	demonstrate	VBD
cord-283382-t890r7xp	160	4	that	that	IN
cord-283382-t890r7xp	160	5	these	these	DT
cord-283382-t890r7xp	160	6	effects	effect	NNS
cord-283382-t890r7xp	160	7	could	could	MD
cord-283382-t890r7xp	160	8	be	be	VB
cord-283382-t890r7xp	160	9	reversed	reverse	VBN
cord-283382-t890r7xp	160	10	by	by	IN
cord-283382-t890r7xp	160	11	immunizing	immunize	VBG
cord-283382-t890r7xp	160	12	mice	mouse	NNS
cord-283382-t890r7xp	160	13	which	which	WDT
cord-283382-t890r7xp	160	14	have	have	VBP
cord-283382-t890r7xp	160	15	a	a	DT
cord-283382-t890r7xp	160	16	defective	defective	JJ
cord-283382-t890r7xp	160	17	type	type	NN
cord-283382-t890r7xp	160	18	I	-PRON-	PRP
cord-283382-t890r7xp	160	19	IFN	IFN	NNP
cord-283382-t890r7xp	160	20	receptor	receptor	NN
cord-283382-t890r7xp	160	21	IFNAR	IFNAR	NNP
cord-283382-t890r7xp	160	22	−/−	−/−	NNP
cord-283382-t890r7xp	160	23	,	,	,
cord-283382-t890r7xp	160	24	resulting	result	VBG
cord-283382-t890r7xp	160	25	in	in	IN
cord-283382-t890r7xp	160	26	an	an	DT
cord-283382-t890r7xp	160	27	increased	increased	JJ
cord-283382-t890r7xp	160	28	Ab	Ab	NNP
cord-283382-t890r7xp	160	29	response	response	NN
cord-283382-t890r7xp	160	30	,	,	,
cord-283382-t890r7xp	160	31	thereby	thereby	RB
cord-283382-t890r7xp	160	32	confirming	confirm	VBG
cord-283382-t890r7xp	160	33	that	that	IN
cord-283382-t890r7xp	160	34	Type	type	NN
cord-283382-t890r7xp	160	35	I	-PRON-	PRP
cord-283382-t890r7xp	160	36	IFN	IFN	NNP
cord-283382-t890r7xp	160	37	stimulation	stimulation	NN
cord-283382-t890r7xp	160	38	can	can	MD
cord-283382-t890r7xp	160	39	have	have	VB
cord-283382-t890r7xp	160	40	a	a	DT
cord-283382-t890r7xp	160	41	detrimental	detrimental	JJ
cord-283382-t890r7xp	160	42	impact	impact	NN
cord-283382-t890r7xp	160	43	on	on	IN
cord-283382-t890r7xp	160	44	humoral	humoral	JJ
cord-283382-t890r7xp	160	45	immunity	immunity	NN
cord-283382-t890r7xp	160	46	directed	direct	VBN
cord-283382-t890r7xp	160	47	toward	toward	IN
cord-283382-t890r7xp	160	48	the	the	DT
cord-283382-t890r7xp	160	49	Ad	ad	NN
cord-283382-t890r7xp	160	50	-	-	HYPH
cord-283382-t890r7xp	160	51	encoded	encode	VBN
cord-283382-t890r7xp	160	52	transgene	transgene	NN
cord-283382-t890r7xp	160	53	Ag	Ag	NNP
cord-283382-t890r7xp	160	54	(	(	-LRB-
cord-283382-t890r7xp	160	55	120	120	CD
cord-283382-t890r7xp	160	56	)	)	-RRB-
cord-283382-t890r7xp	160	57	.	.	.
cord-283382-t890r7xp	161	1	In	in	IN
cord-283382-t890r7xp	161	2	support	support	NN
cord-283382-t890r7xp	161	3	of	of	IN
cord-283382-t890r7xp	161	4	these	these	DT
cord-283382-t890r7xp	161	5	findings	finding	NNS
cord-283382-t890r7xp	161	6	,	,	,
cord-283382-t890r7xp	161	7	Quinn	Quinn	NNP
cord-283382-t890r7xp	161	8	et	et	NNP
cord-283382-t890r7xp	161	9	al	al	NNP
cord-283382-t890r7xp	161	10	.	.	.
cord-283382-t890r7xp	161	11	also	also	RB
cord-283382-t890r7xp	161	12	showed	show	VBD
cord-283382-t890r7xp	161	13	that	that	IN
cord-283382-t890r7xp	161	14	abrogation	abrogation	NN
cord-283382-t890r7xp	161	15	of	of	IN
cord-283382-t890r7xp	161	16	Type	type	NN
cord-283382-t890r7xp	161	17	I	-PRON-	PRP
cord-283382-t890r7xp	161	18	IFN	IFN	NNP
cord-283382-t890r7xp	161	19	and	and	CC
cord-283382-t890r7xp	161	20	STING	STING	NNP
cord-283382-t890r7xp	161	21	could	could	MD
cord-283382-t890r7xp	161	22	increase	increase	VB
cord-283382-t890r7xp	161	23	transgene	transgene	JJ
cord-283382-t890r7xp	161	24	expression	expression	NN
cord-283382-t890r7xp	161	25	from	from	IN
cord-283382-t890r7xp	161	26	rAd	rAd	NNP
cord-283382-t890r7xp	161	27	vaccines	vaccine	NNS
cord-283382-t890r7xp	161	28	,	,	,
cord-283382-t890r7xp	161	29	and	and	CC
cord-283382-t890r7xp	161	30	that	that	IN
cord-283382-t890r7xp	161	31	the	the	DT
cord-283382-t890r7xp	161	32	development	development	NN
cord-283382-t890r7xp	161	33	of	of	IN
cord-283382-t890r7xp	161	34	protective	protective	JJ
cord-283382-t890r7xp	161	35	cellular	cellular	JJ
cord-283382-t890r7xp	161	36	immunity	immunity	NN
cord-283382-t890r7xp	161	37	correlated	correlate	VBN
cord-283382-t890r7xp	161	38	with	with	IN
cord-283382-t890r7xp	161	39	this	this	DT
cord-283382-t890r7xp	161	40	increased	increase	VBN
cord-283382-t890r7xp	161	41	transgene	transgene	NN
cord-283382-t890r7xp	161	42	expression	expression	NN
cord-283382-t890r7xp	161	43	(	(	-LRB-
cord-283382-t890r7xp	161	44	33	33	CD
cord-283382-t890r7xp	161	45	)	)	-RRB-
cord-283382-t890r7xp	161	46	.	.	.
cord-283382-t890r7xp	162	1	Following	follow	VBG
cord-283382-t890r7xp	162	2	immunization	immunization	NN
cord-283382-t890r7xp	162	3	with	with	IN
cord-283382-t890r7xp	162	4	rare	rare	JJ
cord-283382-t890r7xp	162	5	species	specie	NNS
cord-283382-t890r7xp	162	6	and	and	CC
cord-283382-t890r7xp	162	7	non	non	JJ
cord-283382-t890r7xp	162	8	-	-	JJ
cord-283382-t890r7xp	162	9	human	human	JJ
cord-283382-t890r7xp	162	10	Ad	ad	NN
cord-283382-t890r7xp	162	11	vectors	vector	NNS
cord-283382-t890r7xp	162	12	,	,	,
cord-283382-t890r7xp	162	13	the	the	DT
cord-283382-t890r7xp	162	14	authors	author	NNS
cord-283382-t890r7xp	162	15	used	use	VBD
cord-283382-t890r7xp	162	16	a	a	DT
cord-283382-t890r7xp	162	17	systems	system	NNS
cord-283382-t890r7xp	162	18	biology	biology	NN
cord-283382-t890r7xp	162	19	-	-	HYPH
cord-283382-t890r7xp	162	20	based	base	VBN
cord-283382-t890r7xp	162	21	,	,	,
cord-283382-t890r7xp	162	22	gene	gene	NN
cord-283382-t890r7xp	162	23	expression	expression	NN
cord-283382-t890r7xp	162	24	analysis	analysis	NN
cord-283382-t890r7xp	162	25	approach	approach	NN
cord-283382-t890r7xp	162	26	at	at	IN
cord-283382-t890r7xp	162	27	several	several	JJ
cord-283382-t890r7xp	162	28	time	time	NN
cord-283382-t890r7xp	162	29	-	-	HYPH
cord-283382-t890r7xp	162	30	points	point	NNS
cord-283382-t890r7xp	162	31	to	to	TO
cord-283382-t890r7xp	162	32	confirm	confirm	VB
cord-283382-t890r7xp	162	33	the	the	DT
cord-283382-t890r7xp	162	34	differential	differential	JJ
cord-283382-t890r7xp	162	35	modulation	modulation	NN
cord-283382-t890r7xp	162	36	of	of	IN
cord-283382-t890r7xp	162	37	IFN	IFN	NNP
cord-283382-t890r7xp	162	38	responsive	responsive	JJ
cord-283382-t890r7xp	162	39	genes	gene	NNS
cord-283382-t890r7xp	162	40	.	.	.
cord-283382-t890r7xp	163	1	They	-PRON-	PRP
cord-283382-t890r7xp	163	2	determined	determine	VBD
cord-283382-t890r7xp	163	3	that	that	IN
cord-283382-t890r7xp	163	4	Type	type	NN
cord-283382-t890r7xp	163	5	I	-PRON-	PRP
cord-283382-t890r7xp	163	6	and	and	CC
cord-283382-t890r7xp	163	7	Type	Type	NNP
cord-283382-t890r7xp	163	8	II	II	NNP
cord-283382-t890r7xp	163	9	IFNs	ifn	NNS
cord-283382-t890r7xp	163	10	were	be	VBD
cord-283382-t890r7xp	163	11	upregulated	upregulate	VBN
cord-283382-t890r7xp	163	12	at	at	IN
cord-283382-t890r7xp	163	13	8	8	CD
cord-283382-t890r7xp	163	14	h	h	NN
cord-283382-t890r7xp	163	15	post	post	NN
cord-283382-t890r7xp	163	16	-	-	NN
cord-283382-t890r7xp	163	17	immunization	immunization	JJ
cord-283382-t890r7xp	163	18	,	,	,
cord-283382-t890r7xp	163	19	which	which	WDT
cord-283382-t890r7xp	163	20	was	be	VBD
cord-283382-t890r7xp	163	21	followed	follow	VBN
cord-283382-t890r7xp	163	22	by	by	IN
cord-283382-t890r7xp	163	23	the	the	DT
cord-283382-t890r7xp	163	24	induction	induction	NN
cord-283382-t890r7xp	163	25	of	of	IN
cord-283382-t890r7xp	163	26	ISGs	ISGs	NNPS
cord-283382-t890r7xp	163	27	by	by	IN
cord-283382-t890r7xp	163	28	24	24	CD
cord-283382-t890r7xp	163	29	h.	h.	NN
cord-283382-t890r7xp	164	1	Interestingly	interestingly	RB
cord-283382-t890r7xp	164	2	,	,	,
cord-283382-t890r7xp	164	3	the	the	DT
cord-283382-t890r7xp	164	4	most	most	RBS
cord-283382-t890r7xp	164	5	protective	protective	JJ
cord-283382-t890r7xp	164	6	rAds	rad	NNS
cord-283382-t890r7xp	164	7	identified	identify	VBN
cord-283382-t890r7xp	164	8	in	in	IN
cord-283382-t890r7xp	164	9	their	-PRON-	PRP$
cord-283382-t890r7xp	164	10	study	study	NN
cord-283382-t890r7xp	164	11	(	(	-LRB-
cord-283382-t890r7xp	164	12	i.e.	i.e.	FW
cord-283382-t890r7xp	164	13	,	,	,
cord-283382-t890r7xp	164	14	Ad5	ad5	CD
cord-283382-t890r7xp	164	15	and	and	CC
cord-283382-t890r7xp	164	16	chimpanzee	chimpanzee	NN
cord-283382-t890r7xp	164	17	Ad	Ad	NNP
cord-283382-t890r7xp	164	18	,	,	,
cord-283382-t890r7xp	164	19	ChAdV-3	ChAdV-3	NNP
cord-283382-t890r7xp	164	20	)	)	-RRB-
cord-283382-t890r7xp	164	21	exhibited	exhibit	VBD
cord-283382-t890r7xp	164	22	the	the	DT
cord-283382-t890r7xp	164	23	weakest	weak	JJS
cord-283382-t890r7xp	164	24	transcriptional	transcriptional	JJ
cord-283382-t890r7xp	164	25	activation	activation	NN
cord-283382-t890r7xp	164	26	of	of	IN
cord-283382-t890r7xp	164	27	these	these	DT
cord-283382-t890r7xp	164	28	pathways	pathway	NNS
cord-283382-t890r7xp	164	29	.	.	.
cord-283382-t890r7xp	165	1	However	however	RB
cord-283382-t890r7xp	165	2	,	,	,
cord-283382-t890r7xp	165	3	only	only	RB
cord-283382-t890r7xp	165	4	the	the	DT
cord-283382-t890r7xp	165	5	impact	impact	NN
cord-283382-t890r7xp	165	6	of	of	IN
cord-283382-t890r7xp	165	7	innate	innate	JJ
cord-283382-t890r7xp	165	8	gene	gene	NN
cord-283382-t890r7xp	165	9	activation	activation	NN
cord-283382-t890r7xp	165	10	on	on	IN
cord-283382-t890r7xp	165	11	CD8	CD8	NNP
cord-283382-t890r7xp	165	12	+	+	CC
cord-283382-t890r7xp	165	13	T	T	NNP
cord-283382-t890r7xp	165	14	cell	cell	NN
cord-283382-t890r7xp	165	15	responses	response	NNS
cord-283382-t890r7xp	165	16	,	,	,
cord-283382-t890r7xp	165	17	but	but	CC
cord-283382-t890r7xp	165	18	not	not	RB
cord-283382-t890r7xp	165	19	transgene	transgene	NN
cord-283382-t890r7xp	165	20	-	-	HYPH
cord-283382-t890r7xp	165	21	specific	specific	JJ
cord-283382-t890r7xp	165	22	Abs	abs	NN
cord-283382-t890r7xp	165	23	,	,	,
cord-283382-t890r7xp	165	24	was	be	VBD
cord-283382-t890r7xp	165	25	investigated	investigate	VBN
cord-283382-t890r7xp	165	26	(	(	-LRB-
cord-283382-t890r7xp	165	27	33	33	CD
cord-283382-t890r7xp	165	28	)	)	-RRB-
cord-283382-t890r7xp	165	29	.	.	.
cord-283382-t890r7xp	166	1	Nonetheless	nonetheless	RB
cord-283382-t890r7xp	166	2	,	,	,
cord-283382-t890r7xp	166	3	collectively	collectively	RB
cord-283382-t890r7xp	166	4	,	,	,
cord-283382-t890r7xp	166	5	these	these	DT
cord-283382-t890r7xp	166	6	studies	study	NNS
cord-283382-t890r7xp	166	7	support	support	VBP
cord-283382-t890r7xp	166	8	the	the	DT
cord-283382-t890r7xp	166	9	concept	concept	NN
cord-283382-t890r7xp	166	10	of	of	IN
cord-283382-t890r7xp	166	11	robust	robust	JJ
cord-283382-t890r7xp	166	12	,	,	,
cord-283382-t890r7xp	166	13	persistent	persistent	JJ
cord-283382-t890r7xp	166	14	Ag	Ag	NNP
cord-283382-t890r7xp	166	15	expression	expression	NN
cord-283382-t890r7xp	166	16	combined	combine	VBN
cord-283382-t890r7xp	166	17	with	with	IN
cord-283382-t890r7xp	166	18	low	low	JJ
cord-283382-t890r7xp	166	19	innate	innate	JJ
cord-283382-t890r7xp	166	20	gene	gene	NN
cord-283382-t890r7xp	166	21	stimulation	stimulation	NN
cord-283382-t890r7xp	166	22	in	in	IN
cord-283382-t890r7xp	166	23	contributing	contribute	VBG
cord-283382-t890r7xp	166	24	to	to	IN
cord-283382-t890r7xp	166	25	the	the	DT
cord-283382-t890r7xp	166	26	potency	potency	NN
cord-283382-t890r7xp	166	27	of	of	IN
cord-283382-t890r7xp	166	28	rAd	rAd	NNP
cord-283382-t890r7xp	166	29	vaccines	vaccine	NNS
cord-283382-t890r7xp	166	30	(	(	-LRB-
cord-283382-t890r7xp	166	31	33	33	CD
cord-283382-t890r7xp	166	32	,	,	,
cord-283382-t890r7xp	166	33	102	102	CD
cord-283382-t890r7xp	166	34	)	)	-RRB-
cord-283382-t890r7xp	166	35	.	.	.
cord-283382-t890r7xp	167	1	This	this	DT
cord-283382-t890r7xp	167	2	is	be	VBZ
cord-283382-t890r7xp	167	3	also	also	RB
cord-283382-t890r7xp	167	4	supported	support	VBN
cord-283382-t890r7xp	167	5	by	by	IN
cord-283382-t890r7xp	167	6	the	the	DT
cord-283382-t890r7xp	167	7	knowledge	knowledge	NN
cord-283382-t890r7xp	167	8	that	that	WDT
cord-283382-t890r7xp	167	9	relative	relative	JJ
cord-283382-t890r7xp	167	10	to	to	IN
cord-283382-t890r7xp	167	11	rare	rare	JJ
cord-283382-t890r7xp	167	12	species	specie	NNS
cord-283382-t890r7xp	167	13	human	human	JJ
cord-283382-t890r7xp	167	14	and	and	CC
cord-283382-t890r7xp	167	15	non	non	JJ
cord-283382-t890r7xp	167	16	-	-	JJ
cord-283382-t890r7xp	167	17	human	human	JJ
cord-283382-t890r7xp	167	18	Ad	ad	NN
cord-283382-t890r7xp	167	19	vectors	vector	NNS
cord-283382-t890r7xp	167	20	(	(	-LRB-
cord-283382-t890r7xp	167	21	33	33	CD
cord-283382-t890r7xp	167	22	,	,	,
cord-283382-t890r7xp	167	23	120	120	CD
cord-283382-t890r7xp	167	24	)	)	-RRB-
cord-283382-t890r7xp	167	25	,	,	,
cord-283382-t890r7xp	167	26	immunization	immunization	NN
cord-283382-t890r7xp	167	27	with	with	IN
cord-283382-t890r7xp	167	28	the	the	DT
cord-283382-t890r7xp	167	29	potently	potently	RB
cord-283382-t890r7xp	167	30	immunogenic	immunogenic	JJ
cord-283382-t890r7xp	167	31	Ad5	ad5	CD
cord-283382-t890r7xp	167	32	vector	vector	NN
cord-283382-t890r7xp	167	33	is	be	VBZ
cord-283382-t890r7xp	167	34	well	well	RB
cord-283382-t890r7xp	167	35	-	-	HYPH
cord-283382-t890r7xp	167	36	established	establish	VBN
cord-283382-t890r7xp	167	37	to	to	TO
cord-283382-t890r7xp	167	38	result	result	VB
cord-283382-t890r7xp	167	39	in	in	IN
cord-283382-t890r7xp	167	40	robust	robust	JJ
cord-283382-t890r7xp	167	41	,	,	,
cord-283382-t890r7xp	167	42	persistent	persistent	JJ
cord-283382-t890r7xp	167	43	Ag	Ag	NNP
cord-283382-t890r7xp	167	44	expression	expression	NN
cord-283382-t890r7xp	167	45	(	(	-LRB-
cord-283382-t890r7xp	167	46	33	33	CD
cord-283382-t890r7xp	167	47	,	,	,
cord-283382-t890r7xp	167	48	36	36	CD
cord-283382-t890r7xp	167	49	,	,	,
cord-283382-t890r7xp	167	50	41	41	CD
cord-283382-t890r7xp	167	51	,	,	,
cord-283382-t890r7xp	167	52	121	121	CD
cord-283382-t890r7xp	167	53	,	,	,
cord-283382-t890r7xp	167	54	122	122	CD
cord-283382-t890r7xp	167	55	)	)	-RRB-
cord-283382-t890r7xp	167	56	,	,	,
cord-283382-t890r7xp	167	57	while	while	IN
cord-283382-t890r7xp	167	58	triggering	trigger	VBG
cord-283382-t890r7xp	167	59	minimal	minimal	JJ
cord-283382-t890r7xp	167	60	Type	type	NN
cord-283382-t890r7xp	167	61	I	-PRON-	PRP
cord-283382-t890r7xp	167	62	IFN	IFN	NNP
cord-283382-t890r7xp	167	63	responses	response	NNS
cord-283382-t890r7xp	167	64	in	in	IN
cord-283382-t890r7xp	167	65	vivo	vivo	NN
cord-283382-t890r7xp	167	66	.	.	.
cord-283382-t890r7xp	168	1	Future	future	JJ
cord-283382-t890r7xp	168	2	studies	study	NNS
cord-283382-t890r7xp	168	3	which	which	WDT
cord-283382-t890r7xp	168	4	aim	aim	VBP
cord-283382-t890r7xp	168	5	to	to	TO
cord-283382-t890r7xp	168	6	comprehensively	comprehensively	RB
cord-283382-t890r7xp	168	7	characterize	characterize	VB
cord-283382-t890r7xp	168	8	the	the	DT
cord-283382-t890r7xp	168	9	contribution	contribution	NN
cord-283382-t890r7xp	168	10	of	of	IN
cord-283382-t890r7xp	168	11	early	early	JJ
cord-283382-t890r7xp	168	12	innate	innate	JJ
cord-283382-t890r7xp	168	13	immune	immune	JJ
cord-283382-t890r7xp	168	14	activation	activation	NN
cord-283382-t890r7xp	168	15	and	and	CC
cord-283382-t890r7xp	168	16	correlate	correlate	VB
cord-283382-t890r7xp	168	17	this	this	DT
cord-283382-t890r7xp	168	18	with	with	IN
cord-283382-t890r7xp	168	19	the	the	DT
cord-283382-t890r7xp	168	20	downstream	downstream	JJ
cord-283382-t890r7xp	168	21	immunological	immunological	JJ
cord-283382-t890r7xp	168	22	potency	potency	NN
cord-283382-t890r7xp	168	23	and	and	CC
cord-283382-t890r7xp	168	24	efficacy	efficacy	NN
cord-283382-t890r7xp	168	25	of	of	IN
cord-283382-t890r7xp	168	26	lead	lead	JJ
cord-283382-t890r7xp	168	27	Ad	ad	NN
cord-283382-t890r7xp	168	28	vaccine	vaccine	NN
cord-283382-t890r7xp	168	29	platforms	platform	NNS
cord-283382-t890r7xp	168	30	will	will	MD
cord-283382-t890r7xp	168	31	be	be	VB
cord-283382-t890r7xp	168	32	required	require	VBN
cord-283382-t890r7xp	168	33	.	.	.
cord-283382-t890r7xp	169	1	Non	non	JJ
cord-283382-t890r7xp	169	2	-	-	JJ
cord-283382-t890r7xp	169	3	replicating	replicate	VBG
cord-283382-t890r7xp	169	4	Ad5-based	ad5-based	JJ
cord-283382-t890r7xp	169	5	vectors	vector	NNS
cord-283382-t890r7xp	169	6	are	be	VBP
cord-283382-t890r7xp	169	7	well	well	RB
cord-283382-t890r7xp	169	8	-	-	HYPH
cord-283382-t890r7xp	169	9	established	establish	VBN
cord-283382-t890r7xp	169	10	for	for	IN
cord-283382-t890r7xp	169	11	their	-PRON-	PRP$
cord-283382-t890r7xp	169	12	ability	ability	NN
cord-283382-t890r7xp	169	13	to	to	TO
cord-283382-t890r7xp	169	14	confer	confer	VB
cord-283382-t890r7xp	169	15	robust	robust	JJ
cord-283382-t890r7xp	169	16	transgene	transgene	NN
cord-283382-t890r7xp	169	17	expression	expression	NN
cord-283382-t890r7xp	169	18	following	follow	VBG
cord-283382-t890r7xp	169	19	immunization	immunization	NN
cord-283382-t890r7xp	169	20	(	(	-LRB-
cord-283382-t890r7xp	169	21	36	36	CD
cord-283382-t890r7xp	169	22	)	)	-RRB-
cord-283382-t890r7xp	169	23	.	.	.
cord-283382-t890r7xp	170	1	Furthermore	furthermore	RB
cord-283382-t890r7xp	170	2	,	,	,
cord-283382-t890r7xp	170	3	low	low	JJ
cord-283382-t890r7xp	170	4	level	level	NN
cord-283382-t890r7xp	170	5	transgene	transgene	NN
cord-283382-t890r7xp	170	6	expression	expression	NN
cord-283382-t890r7xp	170	7	can	can	MD
cord-283382-t890r7xp	170	8	persist	persist	VB
cord-283382-t890r7xp	170	9	long	long	JJ
cord-283382-t890r7xp	170	10	-	-	HYPH
cord-283382-t890r7xp	170	11	term	term	NN
cord-283382-t890r7xp	170	12	(	(	-LRB-
cord-283382-t890r7xp	170	13	41	41	CD
cord-283382-t890r7xp	170	14	,	,	,
cord-283382-t890r7xp	170	15	122	122	CD
cord-283382-t890r7xp	170	16	)	)	-RRB-
cord-283382-t890r7xp	170	17	,	,	,
cord-283382-t890r7xp	170	18	with	with	IN
cord-283382-t890r7xp	170	19	transcriptionally	transcriptionally	RB
cord-283382-t890r7xp	170	20	active	active	JJ
cord-283382-t890r7xp	170	21	Ad	ad	NN
cord-283382-t890r7xp	170	22	vector	vector	NN
cord-283382-t890r7xp	170	23	genomes	genome	NNS
cord-283382-t890r7xp	170	24	being	be	VBG
cord-283382-t890r7xp	170	25	maintained	maintain	VBN
cord-283382-t890r7xp	170	26	in	in	IN
cord-283382-t890r7xp	170	27	muscle	muscle	NN
cord-283382-t890r7xp	170	28	at	at	IN
cord-283382-t890r7xp	170	29	the	the	DT
cord-283382-t890r7xp	170	30	injection	injection	NN
cord-283382-t890r7xp	170	31	site	site	NN
cord-283382-t890r7xp	170	32	,	,	,
cord-283382-t890r7xp	170	33	or	or	CC
cord-283382-t890r7xp	170	34	within	within	IN
cord-283382-t890r7xp	170	35	draining	drain	VBG
cord-283382-t890r7xp	170	36	lymph	lymph	NN
cord-283382-t890r7xp	170	37	nodes	node	NNS
cord-283382-t890r7xp	170	38	(	(	-LRB-
cord-283382-t890r7xp	170	39	36	36	CD
cord-283382-t890r7xp	170	40	,	,	,
cord-283382-t890r7xp	170	41	122	122	CD
cord-283382-t890r7xp	170	42	)	)	-RRB-
cord-283382-t890r7xp	170	43	,	,	,
cord-283382-t890r7xp	170	44	depending	depend	VBG
cord-283382-t890r7xp	170	45	on	on	IN
cord-283382-t890r7xp	170	46	the	the	DT
cord-283382-t890r7xp	170	47	route	route	NN
cord-283382-t890r7xp	170	48	of	of	IN
cord-283382-t890r7xp	170	49	administration	administration	NN
cord-283382-t890r7xp	170	50	.	.	.
cord-283382-t890r7xp	171	1	As	as	IN
cord-283382-t890r7xp	171	2	previously	previously	RB
cord-283382-t890r7xp	171	3	outlined	outline	VBN
cord-283382-t890r7xp	171	4	,	,	,
cord-283382-t890r7xp	171	5	it	-PRON-	PRP
cord-283382-t890r7xp	171	6	has	have	VBZ
cord-283382-t890r7xp	171	7	been	be	VBN
cord-283382-t890r7xp	171	8	proposed	propose	VBN
cord-283382-t890r7xp	171	9	that	that	IN
cord-283382-t890r7xp	171	10	it	-PRON-	PRP
cord-283382-t890r7xp	171	11	is	be	VBZ
cord-283382-t890r7xp	171	12	this	this	DT
cord-283382-t890r7xp	171	13	magnitude	magnitude	NN
cord-283382-t890r7xp	171	14	and	and	CC
cord-283382-t890r7xp	171	15	persistence	persistence	NN
cord-283382-t890r7xp	171	16	of	of	IN
cord-283382-t890r7xp	171	17	transgene	transgene	NN
cord-283382-t890r7xp	171	18	Ag	Ag	NNP
cord-283382-t890r7xp	171	19	expression	expression	NN
cord-283382-t890r7xp	171	20	which	which	WDT
cord-283382-t890r7xp	171	21	is	be	VBZ
cord-283382-t890r7xp	171	22	crucial	crucial	JJ
cord-283382-t890r7xp	171	23	for	for	IN
cord-283382-t890r7xp	171	24	the	the	DT
cord-283382-t890r7xp	171	25	induction	induction	NN
cord-283382-t890r7xp	171	26	of	of	IN
cord-283382-t890r7xp	171	27	robust	robust	JJ
cord-283382-t890r7xp	171	28	and	and	CC
cord-283382-t890r7xp	171	29	protective	protective	JJ
cord-283382-t890r7xp	171	30	T	t	NN
cord-283382-t890r7xp	171	31	cell	cell	NN
cord-283382-t890r7xp	171	32	responses	response	NNS
cord-283382-t890r7xp	171	33	following	follow	VBG
cord-283382-t890r7xp	171	34	Ad	ad	NN
cord-283382-t890r7xp	171	35	vaccination	vaccination	NN
cord-283382-t890r7xp	171	36	(	(	-LRB-
cord-283382-t890r7xp	171	37	33	33	CD
cord-283382-t890r7xp	171	38	)	)	-RRB-
cord-283382-t890r7xp	171	39	.	.	.
cord-283382-t890r7xp	172	1	As	as	IN
cord-283382-t890r7xp	172	2	described	describe	VBN
cord-283382-t890r7xp	172	3	above	above	RB
cord-283382-t890r7xp	172	4	,	,	,
cord-283382-t890r7xp	172	5	Quinn	Quinn	NNP
cord-283382-t890r7xp	172	6	et	et	NNP
cord-283382-t890r7xp	172	7	al	al	NNP
cord-283382-t890r7xp	172	8	.	.	NNP
cord-283382-t890r7xp	172	9	demonstrated	demonstrate	VBD
cord-283382-t890r7xp	172	10	that	that	IN
cord-283382-t890r7xp	172	11	strong	strong	JJ
cord-283382-t890r7xp	172	12	activation	activation	NN
cord-283382-t890r7xp	172	13	of	of	IN
cord-283382-t890r7xp	172	14	innate	innate	JJ
cord-283382-t890r7xp	172	15	immune	immune	JJ
cord-283382-t890r7xp	172	16	gene	gene	NN
cord-283382-t890r7xp	172	17	expression	expression	NN
cord-283382-t890r7xp	172	18	profiles	profile	NNS
cord-283382-t890r7xp	172	19	in	in	IN
cord-283382-t890r7xp	172	20	the	the	DT
cord-283382-t890r7xp	172	21	draining	drain	VBG
cord-283382-t890r7xp	172	22	lymph	lymph	NN
cord-283382-t890r7xp	172	23	nodes	node	NNS
cord-283382-t890r7xp	172	24	(	(	-LRB-
cord-283382-t890r7xp	172	25	dLNs	dLNs	NNP
cord-283382-t890r7xp	172	26	)	)	-RRB-
cord-283382-t890r7xp	172	27	correlated	correlate	VBN
cord-283382-t890r7xp	172	28	with	with	IN
cord-283382-t890r7xp	172	29	limiting	limit	VBG
cord-283382-t890r7xp	172	30	Ad	ad	NN
cord-283382-t890r7xp	172	31	-	-	HYPH
cord-283382-t890r7xp	172	32	mediated	mediate	VBN
cord-283382-t890r7xp	172	33	transgene	transgene	NN
cord-283382-t890r7xp	172	34	expression	expression	NN
cord-283382-t890r7xp	172	35	for	for	IN
cord-283382-t890r7xp	172	36	many	many	JJ
cord-283382-t890r7xp	172	37	rare	rare	JJ
cord-283382-t890r7xp	172	38	or	or	CC
cord-283382-t890r7xp	172	39	non	non	JJ
cord-283382-t890r7xp	172	40	-	-	JJ
cord-283382-t890r7xp	172	41	human	human	JJ
cord-283382-t890r7xp	172	42	Ad	ad	NN
cord-283382-t890r7xp	172	43	types	type	NNS
cord-283382-t890r7xp	172	44	(	(	-LRB-
cord-283382-t890r7xp	172	45	33	33	CD
cord-283382-t890r7xp	172	46	)	)	-RRB-
cord-283382-t890r7xp	172	47	.	.	.
cord-283382-t890r7xp	173	1	The	the	DT
cord-283382-t890r7xp	173	2	Ad	ad	NN
cord-283382-t890r7xp	173	3	vectors	vector	NNS
cord-283382-t890r7xp	173	4	with	with	IN
cord-283382-t890r7xp	173	5	the	the	DT
cord-283382-t890r7xp	173	6	highest	high	JJS
cord-283382-t890r7xp	173	7	levels	level	NNS
cord-283382-t890r7xp	173	8	of	of	IN
cord-283382-t890r7xp	173	9	transgene	transgene	NN
cord-283382-t890r7xp	173	10	Ad	ad	NN
cord-283382-t890r7xp	173	11	expression	expression	NN
cord-283382-t890r7xp	173	12	in	in	IN
cord-283382-t890r7xp	173	13	dLNs	dLNs	NNP
cord-283382-t890r7xp	173	14	,	,	,
cord-283382-t890r7xp	173	15	Ad5	ad5	CD
cord-283382-t890r7xp	173	16	,	,	,
cord-283382-t890r7xp	173	17	and	and	CC
cord-283382-t890r7xp	173	18	chimpanzee	chimpanzee	NN
cord-283382-t890r7xp	173	19	Ad	ad	NN
cord-283382-t890r7xp	173	20	vector	vector	NN
cord-283382-t890r7xp	173	21	ChAdV-3	chadv-3	NN
cord-283382-t890r7xp	173	22	,	,	,
cord-283382-t890r7xp	173	23	also	also	RB
cord-283382-t890r7xp	173	24	had	have	VBD
cord-283382-t890r7xp	173	25	the	the	DT
cord-283382-t890r7xp	173	26	most	most	RBS
cord-283382-t890r7xp	173	27	attenuated	attenuated	JJ
cord-283382-t890r7xp	173	28	IFN	IFN	NNP
cord-283382-t890r7xp	173	29	induction	induction	NN
cord-283382-t890r7xp	173	30	.	.	.
cord-283382-t890r7xp	174	1	The	the	DT
cord-283382-t890r7xp	174	2	latter	latter	JJ
cord-283382-t890r7xp	174	3	vectors	vector	NNS
cord-283382-t890r7xp	174	4	were	be	VBD
cord-283382-t890r7xp	174	5	both	both	DT
cord-283382-t890r7xp	174	6	potently	potently	RB
cord-283382-t890r7xp	174	7	immunogenic	immunogenic	JJ
cord-283382-t890r7xp	174	8	following	follow	VBG
cord-283382-t890r7xp	174	9	immunization	immunization	NN
cord-283382-t890r7xp	174	10	in	in	IN
cord-283382-t890r7xp	174	11	mice	mouse	NNS
cord-283382-t890r7xp	174	12	.	.	.
cord-283382-t890r7xp	175	1	In	in	IN
cord-283382-t890r7xp	175	2	agreement	agreement	NN
cord-283382-t890r7xp	175	3	with	with	IN
cord-283382-t890r7xp	175	4	this	this	DT
cord-283382-t890r7xp	175	5	,	,	,
cord-283382-t890r7xp	175	6	similar	similar	JJ
cord-283382-t890r7xp	175	7	comparative	comparative	JJ
cord-283382-t890r7xp	175	8	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	175	9	studies	study	NNS
cord-283382-t890r7xp	175	10	in	in	IN
cord-283382-t890r7xp	175	11	mice	mouse	NNS
cord-283382-t890r7xp	175	12	have	have	VBP
cord-283382-t890r7xp	175	13	shown	show	VBN
cord-283382-t890r7xp	175	14	that	that	IN
cord-283382-t890r7xp	175	15	transgene	transgene	JJ
cord-283382-t890r7xp	175	16	expression	expression	NN
cord-283382-t890r7xp	175	17	levels	level	NNS
cord-283382-t890r7xp	175	18	within	within	IN
cord-283382-t890r7xp	175	19	muscle	muscle	NN
cord-283382-t890r7xp	175	20	and	and	CC
cord-283382-t890r7xp	175	21	dLNs	dlns	NN
cord-283382-t890r7xp	175	22	are	be	VBP
cord-283382-t890r7xp	175	23	lower	low	JJR
cord-283382-t890r7xp	175	24	following	follow	VBG
cord-283382-t890r7xp	175	25	immunization	immunization	NN
cord-283382-t890r7xp	175	26	with	with	IN
cord-283382-t890r7xp	175	27	a	a	DT
cord-283382-t890r7xp	175	28	chimpanzee	chimpanzee	NN
cord-283382-t890r7xp	175	29	Ad	ad	NN
cord-283382-t890r7xp	175	30	vector	vector	NN
cord-283382-t890r7xp	175	31	,	,	,
cord-283382-t890r7xp	175	32	ChAdOx1	ChAdOx1	NNP
cord-283382-t890r7xp	175	33	,	,	,
cord-283382-t890r7xp	175	34	when	when	WRB
cord-283382-t890r7xp	175	35	compared	compare	VBN
cord-283382-t890r7xp	175	36	with	with	IN
cord-283382-t890r7xp	175	37	Ad5	ad5	CD
cord-283382-t890r7xp	175	38	,	,	,
cord-283382-t890r7xp	175	39	and	and	CC
cord-283382-t890r7xp	175	40	that	that	IN
cord-283382-t890r7xp	175	41	this	this	DT
cord-283382-t890r7xp	175	42	translates	translate	VBZ
cord-283382-t890r7xp	175	43	to	to	TO
cord-283382-t890r7xp	175	44	superior	superior	JJ
cord-283382-t890r7xp	175	45	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	175	46	observed	observe	VBN
cord-283382-t890r7xp	175	47	with	with	IN
cord-283382-t890r7xp	175	48	Ad5	Ad5	NNP
cord-283382-t890r7xp	175	49	(	(	-LRB-
cord-283382-t890r7xp	175	50	123	123	CD
cord-283382-t890r7xp	175	51	)	)	-RRB-
cord-283382-t890r7xp	175	52	.	.	.
cord-283382-t890r7xp	176	1	To	to	TO
cord-283382-t890r7xp	176	2	directly	directly	RB
cord-283382-t890r7xp	176	3	address	address	VB
cord-283382-t890r7xp	176	4	the	the	DT
cord-283382-t890r7xp	176	5	question	question	NN
cord-283382-t890r7xp	176	6	of	of	IN
cord-283382-t890r7xp	176	7	how	how	WRB
cord-283382-t890r7xp	176	8	persistence	persistence	NN
cord-283382-t890r7xp	176	9	of	of	IN
cord-283382-t890r7xp	176	10	Ag	Ag	NNP
cord-283382-t890r7xp	176	11	contributes	contribute	VBZ
cord-283382-t890r7xp	176	12	to	to	IN
cord-283382-t890r7xp	176	13	the	the	DT
cord-283382-t890r7xp	176	14	induction	induction	NN
cord-283382-t890r7xp	176	15	of	of	IN
cord-283382-t890r7xp	176	16	the	the	DT
cord-283382-t890r7xp	176	17	robust	robust	JJ
cord-283382-t890r7xp	176	18	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	176	19	of	of	IN
cord-283382-t890r7xp	176	20	Ad	ad	NN
cord-283382-t890r7xp	176	21	vaccines	vaccine	NNS
cord-283382-t890r7xp	176	22	,	,	,
cord-283382-t890r7xp	176	23	Finn	Finn	NNP
cord-283382-t890r7xp	176	24	et	et	NNP
cord-283382-t890r7xp	176	25	al	al	NNP
cord-283382-t890r7xp	176	26	.	.	.
cord-283382-t890r7xp	177	1	constructed	construct	VBN
cord-283382-t890r7xp	177	2	an	an	DT
cord-283382-t890r7xp	177	3	Ad	ad	NN
cord-283382-t890r7xp	177	4	vaccine	vaccine	NN
cord-283382-t890r7xp	177	5	with	with	IN
cord-283382-t890r7xp	177	6	a	a	DT
cord-283382-t890r7xp	177	7	doxycycline	doxycycline	NN
cord-283382-t890r7xp	177	8	-	-	HYPH
cord-283382-t890r7xp	177	9	regulated	regulate	VBN
cord-283382-t890r7xp	177	10	transgene	transgene	NN
cord-283382-t890r7xp	177	11	expression	expression	NN
cord-283382-t890r7xp	177	12	cassette	cassette	NN
cord-283382-t890r7xp	177	13	(	(	-LRB-
cord-283382-t890r7xp	177	14	121	121	CD
cord-283382-t890r7xp	177	15	)	)	-RRB-
cord-283382-t890r7xp	177	16	.	.	.
cord-283382-t890r7xp	178	1	By	by	IN
cord-283382-t890r7xp	178	2	switching	switch	VBG
cord-283382-t890r7xp	178	3	off	off	RP
cord-283382-t890r7xp	178	4	transgene	transgene	JJ
cord-283382-t890r7xp	178	5	expression	expression	NN
cord-283382-t890r7xp	178	6	at	at	IN
cord-283382-t890r7xp	178	7	early	early	JJ
cord-283382-t890r7xp	178	8	vs.	vs.	CC
cord-283382-t890r7xp	178	9	late	late	JJ
cord-283382-t890r7xp	178	10	time	time	NN
cord-283382-t890r7xp	178	11	-	-	HYPH
cord-283382-t890r7xp	178	12	points	point	NNS
cord-283382-t890r7xp	178	13	post	post	NN
cord-283382-t890r7xp	178	14	-	-	NN
cord-283382-t890r7xp	178	15	immunization	immunization	NN
cord-283382-t890r7xp	178	16	,	,	,
cord-283382-t890r7xp	178	17	the	the	DT
cord-283382-t890r7xp	178	18	authors	author	NNS
cord-283382-t890r7xp	178	19	confirmed	confirm	VBD
cord-283382-t890r7xp	178	20	the	the	DT
cord-283382-t890r7xp	178	21	importance	importance	NN
cord-283382-t890r7xp	178	22	of	of	IN
cord-283382-t890r7xp	178	23	presence	presence	NN
cord-283382-t890r7xp	178	24	of	of	IN
cord-283382-t890r7xp	178	25	Ag	Ag	NNP
cord-283382-t890r7xp	178	26	in	in	IN
cord-283382-t890r7xp	178	27	expanding	expand	VBG
cord-283382-t890r7xp	178	28	and	and	CC
cord-283382-t890r7xp	178	29	maintaining	maintain	VBG
cord-283382-t890r7xp	178	30	memory	memory	NN
cord-283382-t890r7xp	178	31	T	T	NNP
cord-283382-t890r7xp	178	32	cell	cell	NN
cord-283382-t890r7xp	178	33	responses	response	NNS
cord-283382-t890r7xp	178	34	up	up	RP
cord-283382-t890r7xp	178	35	to	to	IN
cord-283382-t890r7xp	178	36	D30	D30	NNP
cord-283382-t890r7xp	178	37	,	,	,
cord-283382-t890r7xp	178	38	but	but	CC
cord-283382-t890r7xp	178	39	showed	show	VBD
cord-283382-t890r7xp	178	40	that	that	IN
cord-283382-t890r7xp	178	41	the	the	DT
cord-283382-t890r7xp	178	42	maintenance	maintenance	NN
cord-283382-t890r7xp	178	43	of	of	IN
cord-283382-t890r7xp	178	44	memory	memory	NN
cord-283382-t890r7xp	178	45	responses	response	NNS
cord-283382-t890r7xp	178	46	at	at	IN
cord-283382-t890r7xp	178	47	later	later	JJ
cord-283382-t890r7xp	178	48	time	time	NN
cord-283382-t890r7xp	178	49	-	-	HYPH
cord-283382-t890r7xp	178	50	points	point	NNS
cord-283382-t890r7xp	178	51	(	(	-LRB-
cord-283382-t890r7xp	178	52	D60	D60	NNP
cord-283382-t890r7xp	178	53	)	)	-RRB-
cord-283382-t890r7xp	178	54	is	be	VBZ
cord-283382-t890r7xp	178	55	independent	independent	JJ
cord-283382-t890r7xp	178	56	of	of	IN
cord-283382-t890r7xp	178	57	transgene	transgene	JJ
cord-283382-t890r7xp	178	58	expression	expression	NN
cord-283382-t890r7xp	178	59	.	.	.
cord-283382-t890r7xp	179	1	As	as	IN
cord-283382-t890r7xp	179	2	discussed	discuss	VBN
cord-283382-t890r7xp	179	3	above	above	RB
cord-283382-t890r7xp	179	4	,	,	,
cord-283382-t890r7xp	179	5	it	-PRON-	PRP
cord-283382-t890r7xp	179	6	is	be	VBZ
cord-283382-t890r7xp	179	7	apparent	apparent	JJ
cord-283382-t890r7xp	179	8	that	that	IN
cord-283382-t890r7xp	179	9	a	a	DT
cord-283382-t890r7xp	179	10	combination	combination	NN
cord-283382-t890r7xp	179	11	of	of	IN
cord-283382-t890r7xp	179	12	multiple	multiple	JJ
cord-283382-t890r7xp	179	13	parameters	parameter	NNS
cord-283382-t890r7xp	179	14	influences	influence	NNS
cord-283382-t890r7xp	179	15	the	the	DT
cord-283382-t890r7xp	179	16	extent	extent	NN
cord-283382-t890r7xp	179	17	of	of	IN
cord-283382-t890r7xp	179	18	transgene	transgene	JJ
cord-283382-t890r7xp	179	19	expression	expression	NN
cord-283382-t890r7xp	179	20	.	.	.
cord-283382-t890r7xp	180	1	These	these	DT
cord-283382-t890r7xp	180	2	factors	factor	NNS
cord-283382-t890r7xp	180	3	include	include	VBP
cord-283382-t890r7xp	180	4	the	the	DT
cord-283382-t890r7xp	180	5	receptor	receptor	NN
cord-283382-t890r7xp	180	6	usage	usage	NN
cord-283382-t890r7xp	180	7	and	and	CC
cord-283382-t890r7xp	180	8	cellular	cellular	JJ
cord-283382-t890r7xp	180	9	tropism	tropism	NN
cord-283382-t890r7xp	180	10	of	of	IN
cord-283382-t890r7xp	180	11	each	each	DT
cord-283382-t890r7xp	180	12	Ad	ad	NN
cord-283382-t890r7xp	180	13	vector	vector	NN
cord-283382-t890r7xp	180	14	,	,	,
cord-283382-t890r7xp	180	15	the	the	DT
cord-283382-t890r7xp	180	16	presence	presence	NN
cord-283382-t890r7xp	180	17	and	and	CC
cord-283382-t890r7xp	180	18	accessibility	accessibility	NN
cord-283382-t890r7xp	180	19	of	of	IN
cord-283382-t890r7xp	180	20	specific	specific	JJ
cord-283382-t890r7xp	180	21	cell	cell	NN
cord-283382-t890r7xp	180	22	types	type	NNS
cord-283382-t890r7xp	180	23	at	at	IN
cord-283382-t890r7xp	180	24	the	the	DT
cord-283382-t890r7xp	180	25	site	site	NN
cord-283382-t890r7xp	180	26	of	of	IN
cord-283382-t890r7xp	180	27	injection	injection	NN
cord-283382-t890r7xp	180	28	,	,	,
cord-283382-t890r7xp	180	29	in	in	IN
cord-283382-t890r7xp	180	30	addition	addition	NN
cord-283382-t890r7xp	180	31	to	to	IN
cord-283382-t890r7xp	180	32	differences	difference	NNS
cord-283382-t890r7xp	180	33	in	in	IN
cord-283382-t890r7xp	180	34	the	the	DT
cord-283382-t890r7xp	180	35	induction	induction	NN
cord-283382-t890r7xp	180	36	of	of	IN
cord-283382-t890r7xp	180	37	early	early	JJ
cord-283382-t890r7xp	180	38	innate	innate	JJ
cord-283382-t890r7xp	180	39	immunity	immunity	NN
cord-283382-t890r7xp	180	40	by	by	IN
cord-283382-t890r7xp	180	41	diverse	diverse	JJ
cord-283382-t890r7xp	180	42	Ad	ad	NN
cord-283382-t890r7xp	180	43	vectors	vector	NNS
cord-283382-t890r7xp	180	44	.	.	.
cord-283382-t890r7xp	181	1	Collectively	collectively	RB
cord-283382-t890r7xp	181	2	,	,	,
cord-283382-t890r7xp	181	3	these	these	DT
cord-283382-t890r7xp	181	4	parameters	parameter	NNS
cord-283382-t890r7xp	181	5	shape	shape	VBP
cord-283382-t890r7xp	181	6	subsequent	subsequent	JJ
cord-283382-t890r7xp	181	7	adaptive	adaptive	JJ
cord-283382-t890r7xp	181	8	immune	immune	JJ
cord-283382-t890r7xp	181	9	responses	response	NNS
cord-283382-t890r7xp	181	10	.	.	.
cord-283382-t890r7xp	182	1	The	the	DT
cord-283382-t890r7xp	182	2	successful	successful	JJ
cord-283382-t890r7xp	182	3	transduction	transduction	NN
cord-283382-t890r7xp	182	4	of	of	IN
cord-283382-t890r7xp	182	5	cells	cell	NNS
cord-283382-t890r7xp	182	6	at	at	IN
cord-283382-t890r7xp	182	7	the	the	DT
cord-283382-t890r7xp	182	8	site	site	NN
cord-283382-t890r7xp	182	9	of	of	IN
cord-283382-t890r7xp	182	10	vaccine	vaccine	NN
cord-283382-t890r7xp	182	11	administration	administration	NN
cord-283382-t890r7xp	182	12	,	,	,
cord-283382-t890r7xp	182	13	and	and	CC
cord-283382-t890r7xp	182	14	subsequent	subsequent	JJ
cord-283382-t890r7xp	182	15	engagement	engagement	NN
cord-283382-t890r7xp	182	16	of	of	IN
cord-283382-t890r7xp	182	17	defined	define	VBN
cord-283382-t890r7xp	182	18	and	and	CC
cord-283382-t890r7xp	182	19	desirable	desirable	JJ
cord-283382-t890r7xp	182	20	PRRs	prr	NNS
cord-283382-t890r7xp	182	21	which	which	WDT
cord-283382-t890r7xp	182	22	result	result	VBP
cord-283382-t890r7xp	182	23	in	in	IN
cord-283382-t890r7xp	182	24	robust	robust	JJ
cord-283382-t890r7xp	182	25	transgene	transgene	NN
cord-283382-t890r7xp	182	26	expression	expression	NN
cord-283382-t890r7xp	182	27	,	,	,
cord-283382-t890r7xp	182	28	depend	depend	VB
cord-283382-t890r7xp	182	29	on	on	IN
cord-283382-t890r7xp	182	30	the	the	DT
cord-283382-t890r7xp	182	31	cell	cell	NN
cord-283382-t890r7xp	182	32	type	type	NN
cord-283382-t890r7xp	182	33	and	and	CC
cord-283382-t890r7xp	182	34	the	the	DT
cord-283382-t890r7xp	182	35	specific	specific	JJ
cord-283382-t890r7xp	182	36	Ad	ad	NN
cord-283382-t890r7xp	182	37	vector	vector	NN
cord-283382-t890r7xp	182	38	being	be	VBG
cord-283382-t890r7xp	182	39	studied	study	VBN
cord-283382-t890r7xp	182	40	.	.	.
cord-283382-t890r7xp	183	1	With	with	IN
cord-283382-t890r7xp	183	2	this	this	DT
cord-283382-t890r7xp	183	3	in	in	IN
cord-283382-t890r7xp	183	4	mind	mind	NN
cord-283382-t890r7xp	183	5	,	,	,
cord-283382-t890r7xp	183	6	much	much	JJ
cord-283382-t890r7xp	183	7	of	of	IN
cord-283382-t890r7xp	183	8	the	the	DT
cord-283382-t890r7xp	183	9	evidence	evidence	NN
cord-283382-t890r7xp	183	10	to	to	IN
cord-283382-t890r7xp	183	11	date	date	NN
cord-283382-t890r7xp	183	12	has	have	VBZ
cord-283382-t890r7xp	183	13	focused	focus	VBN
cord-283382-t890r7xp	183	14	on	on	IN
cord-283382-t890r7xp	183	15	characterizing	characterize	VBG
cord-283382-t890r7xp	183	16	the	the	DT
cord-283382-t890r7xp	183	17	induction	induction	NN
cord-283382-t890r7xp	183	18	of	of	IN
cord-283382-t890r7xp	183	19	innate	innate	JJ
cord-283382-t890r7xp	183	20	immune	immune	JJ
cord-283382-t890r7xp	183	21	responses	response	NNS
cord-283382-t890r7xp	183	22	in	in	IN
cord-283382-t890r7xp	183	23	vitro	vitro	FW
cord-283382-t890r7xp	183	24	in	in	IN
cord-283382-t890r7xp	183	25	APCs	apc	NNS
cord-283382-t890r7xp	183	26	such	such	JJ
cord-283382-t890r7xp	183	27	as	as	IN
cord-283382-t890r7xp	183	28	DCs	dc	NNS
cord-283382-t890r7xp	183	29	or	or	CC
cord-283382-t890r7xp	183	30	macrophages	macrophage	NNS
cord-283382-t890r7xp	183	31	,	,	,
cord-283382-t890r7xp	183	32	which	which	WDT
cord-283382-t890r7xp	183	33	play	play	VBP
cord-283382-t890r7xp	183	34	important	important	JJ
cord-283382-t890r7xp	183	35	roles	role	NNS
cord-283382-t890r7xp	183	36	in	in	IN
cord-283382-t890r7xp	183	37	initiating	initiate	VBG
cord-283382-t890r7xp	183	38	anti	anti	JJ
cord-283382-t890r7xp	183	39	-	-	JJ
cord-283382-t890r7xp	183	40	viral	viral	JJ
cord-283382-t890r7xp	183	41	immune	immune	JJ
cord-283382-t890r7xp	183	42	responses	response	NNS
cord-283382-t890r7xp	183	43	.	.	.
cord-283382-t890r7xp	184	1	It	-PRON-	PRP
cord-283382-t890r7xp	184	2	is	be	VBZ
cord-283382-t890r7xp	184	3	considered	consider	VBN
cord-283382-t890r7xp	184	4	that	that	IN
cord-283382-t890r7xp	184	5	inflammation	inflammation	NN
cord-283382-t890r7xp	184	6	induced	induce	VBN
cord-283382-t890r7xp	184	7	at	at	IN
cord-283382-t890r7xp	184	8	the	the	DT
cord-283382-t890r7xp	184	9	injection	injection	NN
cord-283382-t890r7xp	184	10	site	site	NN
cord-283382-t890r7xp	184	11	,	,	,
cord-283382-t890r7xp	184	12	can	can	MD
cord-283382-t890r7xp	184	13	lead	lead	VB
cord-283382-t890r7xp	184	14	to	to	IN
cord-283382-t890r7xp	184	15	an	an	DT
cord-283382-t890r7xp	184	16	influx	influx	NN
cord-283382-t890r7xp	184	17	of	of	IN
cord-283382-t890r7xp	184	18	APCs	apc	NNS
cord-283382-t890r7xp	184	19	(	(	-LRB-
cord-283382-t890r7xp	184	20	monocytes	monocyte	NNS
cord-283382-t890r7xp	184	21	or	or	CC
cord-283382-t890r7xp	184	22	DCs	DCs	NNP
cord-283382-t890r7xp	184	23	)	)	-RRB-
cord-283382-t890r7xp	184	24	which	which	WDT
cord-283382-t890r7xp	184	25	carry	carry	VBP
cord-283382-t890r7xp	184	26	Ag	Ag	NNP
cord-283382-t890r7xp	184	27	to	to	IN
cord-283382-t890r7xp	184	28	the	the	DT
cord-283382-t890r7xp	184	29	dLNs	dlns	XX
cord-283382-t890r7xp	185	1	(	(	-LRB-
cord-283382-t890r7xp	185	2	124	124	CD
cord-283382-t890r7xp	185	3	)	)	-RRB-
cord-283382-t890r7xp	185	4	.	.	.
cord-283382-t890r7xp	186	1	Immature	immature	JJ
cord-283382-t890r7xp	186	2	DCs	dc	NNS
cord-283382-t890r7xp	186	3	residing	reside	VBG
cord-283382-t890r7xp	186	4	at	at	IN
cord-283382-t890r7xp	186	5	the	the	DT
cord-283382-t890r7xp	186	6	site	site	NN
cord-283382-t890r7xp	186	7	of	of	IN
cord-283382-t890r7xp	186	8	vaccination	vaccination	NN
cord-283382-t890r7xp	186	9	respond	respond	VBP
cord-283382-t890r7xp	186	10	to	to	TO
cord-283382-t890r7xp	186	11	innate	innate	VB
cord-283382-t890r7xp	186	12	immune	immune	JJ
cord-283382-t890r7xp	186	13	signals	signal	NNS
cord-283382-t890r7xp	186	14	(	(	-LRB-
cord-283382-t890r7xp	186	15	i.e.	i.e.	FW
cord-283382-t890r7xp	186	16	,	,	,
cord-283382-t890r7xp	186	17	stimulation	stimulation	NN
cord-283382-t890r7xp	186	18	of	of	IN
cord-283382-t890r7xp	186	19	TLR	TLR	NNP
cord-283382-t890r7xp	186	20	pathways	pathway	NNS
cord-283382-t890r7xp	186	21	)	)	-RRB-
cord-283382-t890r7xp	186	22	by	by	IN
cord-283382-t890r7xp	186	23	undergoing	undergo	VBG
cord-283382-t890r7xp	186	24	maturation	maturation	NN
cord-283382-t890r7xp	186	25	,	,	,
cord-283382-t890r7xp	186	26	upregulating	upregulate	VBG
cord-283382-t890r7xp	186	27	co	co	JJ
cord-283382-t890r7xp	186	28	-	-	JJ
cord-283382-t890r7xp	186	29	stimulatory	stimulatory	JJ
cord-283382-t890r7xp	186	30	molecules	molecule	NNS
cord-283382-t890r7xp	186	31	and	and	CC
cord-283382-t890r7xp	186	32	migrating	migrate	VBG
cord-283382-t890r7xp	186	33	to	to	IN
cord-283382-t890r7xp	186	34	dLNs	dlns	XX
cord-283382-t890r7xp	186	35	where	where	WRB
cord-283382-t890r7xp	186	36	they	-PRON-	PRP
cord-283382-t890r7xp	186	37	present	present	VBP
cord-283382-t890r7xp	186	38	Ag	Ag	NNP
cord-283382-t890r7xp	186	39	to	to	TO
cord-283382-t890r7xp	186	40	naïve	naïve	JJ
cord-283382-t890r7xp	186	41	T	t	NN
cord-283382-t890r7xp	186	42	cells	cell	NNS
cord-283382-t890r7xp	186	43	(	(	-LRB-
cord-283382-t890r7xp	186	44	124	124	CD
cord-283382-t890r7xp	186	45	)	)	-RRB-
cord-283382-t890r7xp	186	46	.	.	.
cord-283382-t890r7xp	187	1	However	however	RB
cord-283382-t890r7xp	187	2	,	,	,
cord-283382-t890r7xp	187	3	non	non	JJ
cord-283382-t890r7xp	187	4	-	-	JJ
cord-283382-t890r7xp	187	5	professional	professional	JJ
cord-283382-t890r7xp	187	6	APCs	apc	NNS
cord-283382-t890r7xp	187	7	expressing	express	VBG
cord-283382-t890r7xp	187	8	MHC	MHC	NNP
cord-283382-t890r7xp	187	9	I	I	NNP
cord-283382-t890r7xp	187	10	(	(	-LRB-
cord-283382-t890r7xp	187	11	125	125	CD
cord-283382-t890r7xp	187	12	,	,	,
cord-283382-t890r7xp	187	13	126	126	CD
cord-283382-t890r7xp	187	14	)	)	-RRB-
cord-283382-t890r7xp	187	15	,	,	,
cord-283382-t890r7xp	187	16	such	such	JJ
cord-283382-t890r7xp	187	17	as	as	IN
cord-283382-t890r7xp	187	18	tissue	tissue	NN
cord-283382-t890r7xp	187	19	-	-	HYPH
cord-283382-t890r7xp	187	20	specific	specific	JJ
cord-283382-t890r7xp	187	21	epithelial	epithelial	JJ
cord-283382-t890r7xp	187	22	or	or	CC
cord-283382-t890r7xp	187	23	endothelial	endothelial	JJ
cord-283382-t890r7xp	187	24	cells	cell	NNS
cord-283382-t890r7xp	187	25	,	,	,
cord-283382-t890r7xp	187	26	could	could	MD
cord-283382-t890r7xp	187	27	also	also	RB
cord-283382-t890r7xp	187	28	contribute	contribute	VB
cord-283382-t890r7xp	187	29	to	to	IN
cord-283382-t890r7xp	187	30	the	the	DT
cord-283382-t890r7xp	187	31	immune	immune	JJ
cord-283382-t890r7xp	187	32	sensing	sensing	NN
cord-283382-t890r7xp	187	33	of	of	IN
cord-283382-t890r7xp	187	34	Ad	ad	NN
cord-283382-t890r7xp	187	35	vectors	vector	NNS
cord-283382-t890r7xp	187	36	at	at	IN
cord-283382-t890r7xp	187	37	the	the	DT
cord-283382-t890r7xp	187	38	site	site	NN
cord-283382-t890r7xp	187	39	of	of	IN
cord-283382-t890r7xp	187	40	injection	injection	NN
cord-283382-t890r7xp	187	41	(	(	-LRB-
cord-283382-t890r7xp	187	42	39	39	CD
cord-283382-t890r7xp	187	43	)	)	-RRB-
cord-283382-t890r7xp	187	44	.	.	.
cord-283382-t890r7xp	188	1	Therefore	therefore	RB
cord-283382-t890r7xp	188	2	,	,	,
cord-283382-t890r7xp	188	3	it	-PRON-	PRP
cord-283382-t890r7xp	188	4	is	be	VBZ
cord-283382-t890r7xp	188	5	clear	clear	JJ
cord-283382-t890r7xp	188	6	that	that	IN
cord-283382-t890r7xp	188	7	the	the	DT
cord-283382-t890r7xp	188	8	route	route	NN
cord-283382-t890r7xp	188	9	of	of	IN
cord-283382-t890r7xp	188	10	vaccine	vaccine	NNP
cord-283382-t890r7xp	188	11	administration	administration	NN
cord-283382-t890r7xp	188	12	(	(	-LRB-
cord-283382-t890r7xp	188	13	45	45	CD
cord-283382-t890r7xp	188	14	,	,	,
cord-283382-t890r7xp	188	15	127	127	CD
cord-283382-t890r7xp	188	16	,	,	,
cord-283382-t890r7xp	188	17	128	128	CD
cord-283382-t890r7xp	188	18	)	)	-RRB-
cord-283382-t890r7xp	188	19	,	,	,
cord-283382-t890r7xp	188	20	the	the	DT
cord-283382-t890r7xp	188	21	abundance	abundance	NN
cord-283382-t890r7xp	188	22	and	and	CC
cord-283382-t890r7xp	188	23	accessibility	accessibility	NN
cord-283382-t890r7xp	188	24	of	of	IN
cord-283382-t890r7xp	188	25	cell	cell	NN
cord-283382-t890r7xp	188	26	types	type	NNS
cord-283382-t890r7xp	188	27	at	at	IN
cord-283382-t890r7xp	188	28	those	those	DT
cord-283382-t890r7xp	188	29	locations	location	NNS
cord-283382-t890r7xp	188	30	,	,	,
cord-283382-t890r7xp	188	31	as	as	RB
cord-283382-t890r7xp	188	32	well	well	RB
cord-283382-t890r7xp	188	33	as	as	IN
cord-283382-t890r7xp	188	34	the	the	DT
cord-283382-t890r7xp	188	35	surface	surface	NN
cord-283382-t890r7xp	188	36	expression	expression	NN
cord-283382-t890r7xp	188	37	of	of	IN
cord-283382-t890r7xp	188	38	suitable	suitable	JJ
cord-283382-t890r7xp	188	39	entry	entry	NN
cord-283382-t890r7xp	188	40	receptors	receptor	NNS
cord-283382-t890r7xp	188	41	,	,	,
cord-283382-t890r7xp	188	42	will	will	MD
cord-283382-t890r7xp	188	43	profoundly	profoundly	RB
cord-283382-t890r7xp	188	44	affect	affect	VB
cord-283382-t890r7xp	188	45	the	the	DT
cord-283382-t890r7xp	188	46	immunological	immunological	JJ
cord-283382-t890r7xp	188	47	potency	potency	NN
cord-283382-t890r7xp	188	48	and	and	CC
cord-283382-t890r7xp	188	49	protective	protective	JJ
cord-283382-t890r7xp	188	50	efficacy	efficacy	NN
cord-283382-t890r7xp	188	51	of	of	IN
cord-283382-t890r7xp	188	52	a	a	DT
cord-283382-t890r7xp	188	53	chosen	choose	VBN
cord-283382-t890r7xp	188	54	Ad	ad	NN
cord-283382-t890r7xp	188	55	vector	vector	NN
cord-283382-t890r7xp	188	56	.	.	.
cord-283382-t890r7xp	189	1	As	as	IN
cord-283382-t890r7xp	189	2	a	a	DT
cord-283382-t890r7xp	189	3	result	result	NN
cord-283382-t890r7xp	189	4	of	of	IN
cord-283382-t890r7xp	189	5	the	the	DT
cord-283382-t890r7xp	189	6	long	long	JJ
cord-283382-t890r7xp	189	7	history	history	NN
cord-283382-t890r7xp	189	8	of	of	IN
cord-283382-t890r7xp	189	9	experimental	experimental	JJ
cord-283382-t890r7xp	189	10	use	use	NN
cord-283382-t890r7xp	189	11	of	of	IN
cord-283382-t890r7xp	189	12	Ad	ad	NN
cord-283382-t890r7xp	189	13	vectors	vector	NNS
cord-283382-t890r7xp	189	14	as	as	IN
cord-283382-t890r7xp	189	15	oncolytic	oncolytic	JJ
cord-283382-t890r7xp	189	16	agents	agent	NNS
cord-283382-t890r7xp	189	17	aimed	aim	VBN
cord-283382-t890r7xp	189	18	at	at	IN
cord-283382-t890r7xp	189	19	treating	treat	VBG
cord-283382-t890r7xp	189	20	disseminated	disseminate	VBN
cord-283382-t890r7xp	189	21	metastases	metastasis	NNS
cord-283382-t890r7xp	189	22	,	,	,
cord-283382-t890r7xp	189	23	a	a	DT
cord-283382-t890r7xp	189	24	significant	significant	JJ
cord-283382-t890r7xp	189	25	amount	amount	NN
cord-283382-t890r7xp	189	26	of	of	IN
cord-283382-t890r7xp	189	27	information	information	NN
cord-283382-t890r7xp	189	28	exists	exist	VBZ
cord-283382-t890r7xp	189	29	in	in	IN
cord-283382-t890r7xp	189	30	the	the	DT
cord-283382-t890r7xp	189	31	literature	literature	NN
cord-283382-t890r7xp	189	32	regarding	regard	VBG
cord-283382-t890r7xp	189	33	interactions	interaction	NNS
cord-283382-t890r7xp	189	34	between	between	IN
cord-283382-t890r7xp	189	35	Ad	ad	NN
cord-283382-t890r7xp	189	36	vectors	vector	NNS
cord-283382-t890r7xp	189	37	,	,	,
cord-283382-t890r7xp	189	38	immune	immune	JJ
cord-283382-t890r7xp	189	39	cells	cell	NNS
cord-283382-t890r7xp	189	40	(	(	-LRB-
cord-283382-t890r7xp	189	41	28	28	CD
cord-283382-t890r7xp	189	42	,	,	,
cord-283382-t890r7xp	189	43	77	77	CD
cord-283382-t890r7xp	189	44	,	,	,
cord-283382-t890r7xp	189	45	129	129	CD
cord-283382-t890r7xp	189	46	)	)	-RRB-
cord-283382-t890r7xp	189	47	,	,	,
cord-283382-t890r7xp	189	48	parenchymal	parenchymal	NN
cord-283382-t890r7xp	189	49	cells	cell	NNS
cord-283382-t890r7xp	189	50	(	(	-LRB-
cord-283382-t890r7xp	189	51	18	18	CD
cord-283382-t890r7xp	189	52	,	,	,
cord-283382-t890r7xp	189	53	63	63	CD
cord-283382-t890r7xp	189	54	,	,	,
cord-283382-t890r7xp	189	55	113	113	CD
cord-283382-t890r7xp	189	56	,	,	,
cord-283382-t890r7xp	189	57	(	(	-LRB-
cord-283382-t890r7xp	189	58	130	130	CD
cord-283382-t890r7xp	189	59	)	)	-RRB-
cord-283382-t890r7xp	189	60	(	(	-LRB-
cord-283382-t890r7xp	189	61	131	131	CD
cord-283382-t890r7xp	189	62	)	)	-RRB-
cord-283382-t890r7xp	189	63	(	(	-LRB-
cord-283382-t890r7xp	189	64	132	132	CD
cord-283382-t890r7xp	189	65	)	)	-RRB-
cord-283382-t890r7xp	189	66	(	(	-LRB-
cord-283382-t890r7xp	189	67	133	133	CD
cord-283382-t890r7xp	189	68	)	)	-RRB-
cord-283382-t890r7xp	189	69	(	(	-LRB-
cord-283382-t890r7xp	189	70	134	134	CD
cord-283382-t890r7xp	189	71	)	)	-RRB-
cord-283382-t890r7xp	189	72	,	,	,
cord-283382-t890r7xp	189	73	and	and	CC
cord-283382-t890r7xp	189	74	stromal	stromal	JJ
cord-283382-t890r7xp	189	75	cells	cell	NNS
cord-283382-t890r7xp	189	76	(	(	-LRB-
cord-283382-t890r7xp	189	77	130	130	CD
cord-283382-t890r7xp	189	78	)	)	-RRB-
cord-283382-t890r7xp	189	79	following	follow	VBG
cord-283382-t890r7xp	189	80	i.v	i.v	NNP
cord-283382-t890r7xp	189	81	.	.	NNP
cord-283382-t890r7xp	189	82	delivery	delivery	NN
cord-283382-t890r7xp	189	83	of	of	IN
cord-283382-t890r7xp	189	84	Ad	ad	NN
cord-283382-t890r7xp	189	85	vectors	vector	NNS
cord-283382-t890r7xp	189	86	(	(	-LRB-
cord-283382-t890r7xp	189	87	18	18	CD
cord-283382-t890r7xp	189	88	,	,	,
cord-283382-t890r7xp	189	89	112	112	CD
cord-283382-t890r7xp	189	90	,	,	,
cord-283382-t890r7xp	189	91	135	135	CD
cord-283382-t890r7xp	189	92	)	)	-RRB-
cord-283382-t890r7xp	189	93	.	.	.
cord-283382-t890r7xp	190	1	However	however	RB
cord-283382-t890r7xp	190	2	,	,	,
cord-283382-t890r7xp	190	3	i.v	i.v	NNP
cord-283382-t890r7xp	190	4	.	.	NNP
cord-283382-t890r7xp	190	5	vaccination	vaccination	NN
cord-283382-t890r7xp	190	6	would	would	MD
cord-283382-t890r7xp	190	7	be	be	VB
cord-283382-t890r7xp	190	8	impractical	impractical	JJ
cord-283382-t890r7xp	190	9	for	for	IN
cord-283382-t890r7xp	190	10	widespread	widespread	JJ
cord-283382-t890r7xp	190	11	population	population	NN
cord-283382-t890r7xp	190	12	use	use	NN
cord-283382-t890r7xp	190	13	and	and	CC
cord-283382-t890r7xp	190	14	so	so	RB
cord-283382-t890r7xp	190	15	immunization	immunization	NN
cord-283382-t890r7xp	190	16	by	by	IN
cord-283382-t890r7xp	190	17	i.m	i.m	NNP
cord-283382-t890r7xp	190	18	.	.	.
cord-283382-t890r7xp	191	1	or	or	CC
cord-283382-t890r7xp	191	2	i.n	i.n	NNP
cord-283382-t890r7xp	191	3	.	.	NNP
cord-283382-t890r7xp	191	4	administration	administration	NN
cord-283382-t890r7xp	191	5	is	be	VBZ
cord-283382-t890r7xp	191	6	preferable	preferable	JJ
cord-283382-t890r7xp	191	7	,	,	,
cord-283382-t890r7xp	191	8	particularly	particularly	RB
cord-283382-t890r7xp	191	9	for	for	IN
cord-283382-t890r7xp	191	10	vaccination	vaccination	NN
cord-283382-t890r7xp	191	11	against	against	IN
cord-283382-t890r7xp	191	12	respiratory	respiratory	JJ
cord-283382-t890r7xp	191	13	pathogens	pathogen	NNS
cord-283382-t890r7xp	191	14	.	.	.
cord-283382-t890r7xp	192	1	Unfortunately	unfortunately	RB
cord-283382-t890r7xp	192	2	,	,	,
cord-283382-t890r7xp	192	3	less	less	RBR
cord-283382-t890r7xp	192	4	is	be	VBZ
cord-283382-t890r7xp	192	5	known	know	VBN
cord-283382-t890r7xp	192	6	about	about	IN
cord-283382-t890r7xp	192	7	the	the	DT
cord-283382-t890r7xp	192	8	precise	precise	JJ
cord-283382-t890r7xp	192	9	interactions	interaction	NNS
cord-283382-t890r7xp	192	10	which	which	WDT
cord-283382-t890r7xp	192	11	occur	occur	VBP
cord-283382-t890r7xp	192	12	at	at	IN
cord-283382-t890r7xp	192	13	the	the	DT
cord-283382-t890r7xp	192	14	site	site	NN
cord-283382-t890r7xp	192	15	of	of	IN
cord-283382-t890r7xp	192	16	injection	injection	NN
cord-283382-t890r7xp	192	17	or	or	CC
cord-283382-t890r7xp	192	18	within	within	IN
cord-283382-t890r7xp	192	19	dLNs	dLNs	NNP
cord-283382-t890r7xp	192	20	in	in	IN
cord-283382-t890r7xp	192	21	vivo	vivo	NNP
cord-283382-t890r7xp	192	22	following	follow	VBG
cord-283382-t890r7xp	192	23	i.m	i.m	NNP
cord-283382-t890r7xp	192	24	.	.	NNP
cord-283382-t890r7xp	192	25	or	or	CC
cord-283382-t890r7xp	192	26	i.n	i.n	NNP
cord-283382-t890r7xp	192	27	.	.	.
cord-283382-t890r7xp	192	28	immunization	immunization	NN
cord-283382-t890r7xp	192	29	with	with	IN
cord-283382-t890r7xp	192	30	Ads	ad	NNS
cord-283382-t890r7xp	192	31	in	in	IN
cord-283382-t890r7xp	192	32	animal	animal	NN
cord-283382-t890r7xp	192	33	models	model	NNS
cord-283382-t890r7xp	192	34	,	,	,
cord-283382-t890r7xp	192	35	and	and	CC
cord-283382-t890r7xp	192	36	these	these	DT
cord-283382-t890r7xp	192	37	questions	question	NNS
cord-283382-t890r7xp	192	38	are	be	VBP
cord-283382-t890r7xp	192	39	even	even	RB
cord-283382-t890r7xp	192	40	more	more	RBR
cord-283382-t890r7xp	192	41	difficult	difficult	JJ
cord-283382-t890r7xp	192	42	to	to	TO
cord-283382-t890r7xp	192	43	address	address	VB
cord-283382-t890r7xp	192	44	in	in	IN
cord-283382-t890r7xp	192	45	humans	human	NNS
cord-283382-t890r7xp	192	46	,	,	,
cord-283382-t890r7xp	192	47	without	without	IN
cord-283382-t890r7xp	192	48	the	the	DT
cord-283382-t890r7xp	192	49	use	use	NN
cord-283382-t890r7xp	192	50	of	of	IN
cord-283382-t890r7xp	192	51	invasive	invasive	JJ
cord-283382-t890r7xp	192	52	procedures	procedure	NNS
cord-283382-t890r7xp	192	53	(	(	-LRB-
cord-283382-t890r7xp	192	54	such	such	JJ
cord-283382-t890r7xp	192	55	as	as	IN
cord-283382-t890r7xp	192	56	fine	fine	JJ
cord-283382-t890r7xp	192	57	needle	needle	NN
cord-283382-t890r7xp	192	58	aspirates	aspirate	NNS
cord-283382-t890r7xp	192	59	of	of	IN
cord-283382-t890r7xp	192	60	lymph	lymph	NN
cord-283382-t890r7xp	192	61	nodes	node	NNS
cord-283382-t890r7xp	192	62	)	)	-RRB-
cord-283382-t890r7xp	192	63	(	(	-LRB-
cord-283382-t890r7xp	192	64	136	136	CD
cord-283382-t890r7xp	192	65	)	)	-RRB-
cord-283382-t890r7xp	192	66	.	.	.
cord-283382-t890r7xp	193	1	The	the	DT
cord-283382-t890r7xp	193	2	cell	cell	NN
cord-283382-t890r7xp	193	3	types	type	NNS
cord-283382-t890r7xp	193	4	present	present	VBP
cord-283382-t890r7xp	193	5	when	when	WRB
cord-283382-t890r7xp	193	6	vaccine	vaccine	NN
cord-283382-t890r7xp	193	7	is	be	VBZ
cord-283382-t890r7xp	193	8	administered	administer	VBN
cord-283382-t890r7xp	193	9	i.m	i.m	NNP
cord-283382-t890r7xp	193	10	.	.	NNP
cord-283382-t890r7xp	193	11	include	include	VBP
cord-283382-t890r7xp	193	12	myocytes	myocyte	NNS
cord-283382-t890r7xp	193	13	,	,	,
cord-283382-t890r7xp	193	14	skeletal	skeletal	JJ
cord-283382-t890r7xp	193	15	muscle	muscle	NN
cord-283382-t890r7xp	193	16	cells	cell	NNS
cord-283382-t890r7xp	193	17	,	,	,
cord-283382-t890r7xp	193	18	fibroblasts	fibroblast	NNS
cord-283382-t890r7xp	193	19	and	and	CC
cord-283382-t890r7xp	193	20	endothelial	endothelial	JJ
cord-283382-t890r7xp	193	21	cells	cell	NNS
cord-283382-t890r7xp	193	22	,	,	,
cord-283382-t890r7xp	193	23	with	with	IN
cord-283382-t890r7xp	193	24	APCs	apc	NNS
cord-283382-t890r7xp	193	25	such	such	JJ
cord-283382-t890r7xp	193	26	as	as	IN
cord-283382-t890r7xp	193	27	DCs	dc	NNS
cord-283382-t890r7xp	193	28	or	or	CC
cord-283382-t890r7xp	193	29	macrophages	macrophage	NNS
cord-283382-t890r7xp	193	30	representing	represent	VBG
cord-283382-t890r7xp	193	31	a	a	DT
cord-283382-t890r7xp	193	32	minority	minority	NN
cord-283382-t890r7xp	193	33	when	when	WRB
cord-283382-t890r7xp	193	34	compared	compare	VBN
cord-283382-t890r7xp	193	35	with	with	IN
cord-283382-t890r7xp	193	36	the	the	DT
cord-283382-t890r7xp	193	37	abundance	abundance	NN
cord-283382-t890r7xp	193	38	of	of	IN
cord-283382-t890r7xp	193	39	murine	murine	JJ
cord-283382-t890r7xp	193	40	skeletal	skeletal	JJ
cord-283382-t890r7xp	193	41	muscle	muscle	NN
cord-283382-t890r7xp	193	42	cells	cell	NNS
cord-283382-t890r7xp	193	43	(	(	-LRB-
cord-283382-t890r7xp	193	44	87	87	CD
cord-283382-t890r7xp	193	45	)	)	-RRB-
cord-283382-t890r7xp	193	46	.	.	.
cord-283382-t890r7xp	194	1	Early	early	JJ
cord-283382-t890r7xp	194	2	studies	study	NNS
cord-283382-t890r7xp	194	3	by	by	IN
cord-283382-t890r7xp	194	4	Mercier	Mercier	NNP
cord-283382-t890r7xp	194	5	et	et	NNP
cord-283382-t890r7xp	194	6	al	al	NNP
cord-283382-t890r7xp	194	7	.	.	NNP
cord-283382-t890r7xp	194	8	demonstrated	demonstrate	VBD
cord-283382-t890r7xp	194	9	that	that	IN
cord-283382-t890r7xp	194	10	transduction	transduction	NN
cord-283382-t890r7xp	194	11	of	of	IN
cord-283382-t890r7xp	194	12	different	different	JJ
cord-283382-t890r7xp	194	13	cell	cell	NN
cord-283382-t890r7xp	194	14	types	type	NNS
cord-283382-t890r7xp	194	15	can	can	MD
cord-283382-t890r7xp	194	16	modulate	modulate	VB
cord-283382-t890r7xp	194	17	the	the	DT
cord-283382-t890r7xp	194	18	outcome	outcome	NN
cord-283382-t890r7xp	194	19	and	and	CC
cord-283382-t890r7xp	194	20	phenotype	phenotype	NN
cord-283382-t890r7xp	194	21	of	of	IN
cord-283382-t890r7xp	194	22	the	the	DT
cord-283382-t890r7xp	194	23	humoral	humoral	JJ
cord-283382-t890r7xp	194	24	immune	immune	JJ
cord-283382-t890r7xp	194	25	response	response	NN
cord-283382-t890r7xp	194	26	following	follow	VBG
cord-283382-t890r7xp	194	27	Ad	ad	NN
cord-283382-t890r7xp	194	28	vaccination	vaccination	NN
cord-283382-t890r7xp	194	29	.	.	.
cord-283382-t890r7xp	195	1	The	the	DT
cord-283382-t890r7xp	195	2	authors	author	NNS
cord-283382-t890r7xp	195	3	transduced	transduce	VBD
cord-283382-t890r7xp	195	4	DCs	DCs	NNP
cord-283382-t890r7xp	195	5	(	(	-LRB-
cord-283382-t890r7xp	195	6	professional	professional	JJ
cord-283382-t890r7xp	195	7	APCs	APCs	NNPS
cord-283382-t890r7xp	195	8	)	)	-RRB-
cord-283382-t890r7xp	195	9	,	,	,
cord-283382-t890r7xp	195	10	myoblasts	myoblasts	NNP
cord-283382-t890r7xp	195	11	(	(	-LRB-
cord-283382-t890r7xp	195	12	progenitor	progenitor	NN
cord-283382-t890r7xp	195	13	cells	cell	NNS
cord-283382-t890r7xp	195	14	which	which	WDT
cord-283382-t890r7xp	195	15	give	give	VBP
cord-283382-t890r7xp	195	16	rise	rise	NN
cord-283382-t890r7xp	195	17	to	to	IN
cord-283382-t890r7xp	195	18	muscle	muscle	NN
cord-283382-t890r7xp	195	19	cells	cell	NNS
cord-283382-t890r7xp	195	20	)	)	-RRB-
cord-283382-t890r7xp	195	21	and	and	CC
cord-283382-t890r7xp	195	22	endothelial	endothelial	JJ
cord-283382-t890r7xp	195	23	cells	cell	NNS
cord-283382-t890r7xp	195	24	ex	ex	FW
cord-283382-t890r7xp	195	25	vivo	vivo	NN
cord-283382-t890r7xp	195	26	with	with	IN
cord-283382-t890r7xp	195	27	Ad5	ad5	CD
cord-283382-t890r7xp	195	28	expressing	express	VBG
cord-283382-t890r7xp	195	29	a	a	DT
cord-283382-t890r7xp	195	30	model	model	NN
cord-283382-t890r7xp	195	31	antigen	antigen	NN
cord-283382-t890r7xp	195	32	β	β	NN
cord-283382-t890r7xp	195	33	-	-	HYPH
cord-283382-t890r7xp	195	34	galactosidase	galactosidase	NNP
cord-283382-t890r7xp	195	35	(	(	-LRB-
cord-283382-t890r7xp	195	36	β	β	NN
cord-283382-t890r7xp	195	37	-	-	HYPH
cord-283382-t890r7xp	195	38	gal	gal	NNP
cord-283382-t890r7xp	195	39	)	)	-RRB-
cord-283382-t890r7xp	195	40	(	(	-LRB-
cord-283382-t890r7xp	195	41	87	87	CD
cord-283382-t890r7xp	195	42	)	)	-RRB-
cord-283382-t890r7xp	195	43	,	,	,
cord-283382-t890r7xp	195	44	and	and	CC
cord-283382-t890r7xp	195	45	vaccinated	vaccinated	JJ
cord-283382-t890r7xp	195	46	mice	mouse	NNS
cord-283382-t890r7xp	196	1	i.m	i.m	NNP
cord-283382-t890r7xp	196	2	.	.	.
cord-283382-t890r7xp	197	1	with	with	IN
cord-283382-t890r7xp	197	2	the	the	DT
cord-283382-t890r7xp	197	3	Ad	ad	NN
cord-283382-t890r7xp	197	4	-	-	HYPH
cord-283382-t890r7xp	197	5	transduced	transduce	VBN
cord-283382-t890r7xp	197	6	cells	cell	NNS
cord-283382-t890r7xp	197	7	.	.	.
cord-283382-t890r7xp	198	1	The	the	DT
cord-283382-t890r7xp	198	2	authors	author	NNS
cord-283382-t890r7xp	198	3	found	find	VBD
cord-283382-t890r7xp	198	4	that	that	IN
cord-283382-t890r7xp	198	5	all	all	DT
cord-283382-t890r7xp	198	6	transduced	transduce	VBN
cord-283382-t890r7xp	198	7	cell	cell	NN
cord-283382-t890r7xp	198	8	types	type	NNS
cord-283382-t890r7xp	198	9	elicited	elicit	VBD
cord-283382-t890r7xp	198	10	humoral	humoral	JJ
cord-283382-t890r7xp	198	11	immune	immune	JJ
cord-283382-t890r7xp	198	12	responses	response	NNS
cord-283382-t890r7xp	198	13	to	to	IN
cord-283382-t890r7xp	198	14	the	the	DT
cord-283382-t890r7xp	198	15	β	β	NN
cord-283382-t890r7xp	198	16	-	-	HYPH
cord-283382-t890r7xp	198	17	gal	gal	NN
cord-283382-t890r7xp	198	18	transgene	transgene	NN
cord-283382-t890r7xp	198	19	to	to	IN
cord-283382-t890r7xp	198	20	a	a	DT
cord-283382-t890r7xp	198	21	similar	similar	JJ
cord-283382-t890r7xp	198	22	extent	extent	NN
cord-283382-t890r7xp	198	23	(	(	-LRB-
cord-283382-t890r7xp	198	24	albeit	albeit	IN
cord-283382-t890r7xp	198	25	with	with	IN
cord-283382-t890r7xp	198	26	differences	difference	NNS
cord-283382-t890r7xp	198	27	in	in	IN
cord-283382-t890r7xp	198	28	their	-PRON-	PRP$
cord-283382-t890r7xp	198	29	temporal	temporal	JJ
cord-283382-t890r7xp	198	30	kinetics	kinetic	NNS
cord-283382-t890r7xp	198	31	)	)	-RRB-
cord-283382-t890r7xp	198	32	,	,	,
cord-283382-t890r7xp	198	33	but	but	CC
cord-283382-t890r7xp	198	34	that	that	IN
cord-283382-t890r7xp	198	35	the	the	DT
cord-283382-t890r7xp	198	36	IgG	igg	NN
cord-283382-t890r7xp	198	37	isotype	isotype	NN
cord-283382-t890r7xp	198	38	subclass	subclass	NN
cord-283382-t890r7xp	198	39	profile	profile	NN
cord-283382-t890r7xp	198	40	differed	differ	VBD
cord-283382-t890r7xp	198	41	.	.	.
cord-283382-t890r7xp	199	1	Injection	injection	NN
cord-283382-t890r7xp	199	2	of	of	IN
cord-283382-t890r7xp	199	3	transduced	transduce	VBN
cord-283382-t890r7xp	199	4	DCs	dc	NNS
cord-283382-t890r7xp	199	5	or	or	CC
cord-283382-t890r7xp	199	6	endothelial	endothelial	JJ
cord-283382-t890r7xp	199	7	cells	cell	NNS
cord-283382-t890r7xp	199	8	resulted	result	VBD
cord-283382-t890r7xp	199	9	in	in	IN
cord-283382-t890r7xp	199	10	production	production	NN
cord-283382-t890r7xp	199	11	of	of	IN
cord-283382-t890r7xp	199	12	Ag	Ag	NNP
cord-283382-t890r7xp	199	13	-	-	HYPH
cord-283382-t890r7xp	199	14	specific	specific	JJ
cord-283382-t890r7xp	199	15	Abs	abs	NN
cord-283382-t890r7xp	199	16	which	which	WDT
cord-283382-t890r7xp	199	17	were	be	VBD
cord-283382-t890r7xp	199	18	exclusively	exclusively	RB
cord-283382-t890r7xp	199	19	IgG	IgG	NNP
cord-283382-t890r7xp	199	20	2a	2a	CD
cord-283382-t890r7xp	199	21	,	,	,
cord-283382-t890r7xp	199	22	whereas	whereas	IN
cord-283382-t890r7xp	199	23	vaccination	vaccination	NN
cord-283382-t890r7xp	199	24	with	with	IN
cord-283382-t890r7xp	199	25	Ad	ad	NN
cord-283382-t890r7xp	199	26	-	-	HYPH
cord-283382-t890r7xp	199	27	transduced	transduce	VBN
cord-283382-t890r7xp	199	28	myoblasts	myoblast	NNS
cord-283382-t890r7xp	199	29	elicited	elicit	VBD
cord-283382-t890r7xp	199	30	a	a	DT
cord-283382-t890r7xp	199	31	more	more	RBR
cord-283382-t890r7xp	199	32	balanced	balanced	JJ
cord-283382-t890r7xp	199	33	Ab	Ab	NNP
cord-283382-t890r7xp	199	34	response	response	NN
cord-283382-t890r7xp	199	35	with	with	IN
cord-283382-t890r7xp	199	36	equivalent	equivalent	JJ
cord-283382-t890r7xp	199	37	IgG	IgG	NNP
cord-283382-t890r7xp	199	38	1	1	CD
cord-283382-t890r7xp	199	39	:	:	:
cord-283382-t890r7xp	199	40	IgG	IgG	NNP
cord-283382-t890r7xp	199	41	2a	2a	CD
cord-283382-t890r7xp	199	42	.	.	.
cord-283382-t890r7xp	200	1	Interestingly	interestingly	RB
cord-283382-t890r7xp	200	2	,	,	,
cord-283382-t890r7xp	200	3	only	only	RB
cord-283382-t890r7xp	200	4	mice	mouse	NNS
cord-283382-t890r7xp	200	5	immunized	immunize	VBN
cord-283382-t890r7xp	200	6	with	with	IN
cord-283382-t890r7xp	200	7	Ad	ad	NN
cord-283382-t890r7xp	200	8	-	-	HYPH
cord-283382-t890r7xp	200	9	transduced	transduce	VBN
cord-283382-t890r7xp	200	10	DCs	DCs	NNP
cord-283382-t890r7xp	200	11	elicited	elicit	VBD
cord-283382-t890r7xp	200	12	robust	robust	JJ
cord-283382-t890r7xp	200	13	CD8	CD8	NNP
cord-283382-t890r7xp	200	14	+	+	CC
cord-283382-t890r7xp	200	15	T	T	NNP
cord-283382-t890r7xp	200	16	cell	cell	NN
cord-283382-t890r7xp	200	17	responses	response	NNS
cord-283382-t890r7xp	200	18	,	,	,
cord-283382-t890r7xp	200	19	as	as	IN
cord-283382-t890r7xp	200	20	did	do	VBD
cord-283382-t890r7xp	200	21	vaccination	vaccination	NN
cord-283382-t890r7xp	200	22	with	with	IN
cord-283382-t890r7xp	200	23	control	control	NN
cord-283382-t890r7xp	200	24	virus	virus	NN
cord-283382-t890r7xp	200	25	Ad	ad	NN
cord-283382-t890r7xp	200	26	-	-	HYPH
cord-283382-t890r7xp	200	27	β	β	NN
cord-283382-t890r7xp	200	28	-	-	HYPH
cord-283382-t890r7xp	200	29	gal	gal	NNP
cord-283382-t890r7xp	200	30	,	,	,
cord-283382-t890r7xp	200	31	suggesting	suggest	VBG
cord-283382-t890r7xp	200	32	that	that	IN
cord-283382-t890r7xp	200	33	Ad	ad	NN
cord-283382-t890r7xp	200	34	interactions	interaction	NNS
cord-283382-t890r7xp	200	35	with	with	IN
cord-283382-t890r7xp	200	36	different	different	JJ
cord-283382-t890r7xp	200	37	cell	cell	NN
cord-283382-t890r7xp	200	38	types	type	NNS
cord-283382-t890r7xp	200	39	in	in	IN
cord-283382-t890r7xp	200	40	vivo	vivo	NN
cord-283382-t890r7xp	200	41	could	could	MD
cord-283382-t890r7xp	200	42	influence	influence	VB
cord-283382-t890r7xp	200	43	divergent	divergent	JJ
cord-283382-t890r7xp	200	44	arms	arm	NNS
cord-283382-t890r7xp	200	45	of	of	IN
cord-283382-t890r7xp	200	46	the	the	DT
cord-283382-t890r7xp	200	47	adaptive	adaptive	JJ
cord-283382-t890r7xp	200	48	immune	immune	JJ
cord-283382-t890r7xp	200	49	response	response	NN
cord-283382-t890r7xp	200	50	.	.	.
cord-283382-t890r7xp	201	1	Bassett	Bassett	NNP
cord-283382-t890r7xp	201	2	et	et	NNP
cord-283382-t890r7xp	201	3	al	al	NNP
cord-283382-t890r7xp	201	4	.	.	.
cord-283382-t890r7xp	202	1	also	also	RB
cord-283382-t890r7xp	202	2	demonstrated	demonstrate	VBD
cord-283382-t890r7xp	202	3	that	that	IN
cord-283382-t890r7xp	202	4	Ag	Ag	NNP
cord-283382-t890r7xp	202	5	presentation	presentation	NN
cord-283382-t890r7xp	202	6	by	by	IN
cord-283382-t890r7xp	202	7	non	non	JJ
cord-283382-t890r7xp	202	8	-	-	JJ
cord-283382-t890r7xp	202	9	lymphoid	lymphoid	JJ
cord-283382-t890r7xp	202	10	cells	cell	NNS
cord-283382-t890r7xp	202	11	,	,	,
cord-283382-t890r7xp	202	12	in	in	IN
cord-283382-t890r7xp	202	13	cooperation	cooperation	NN
cord-283382-t890r7xp	202	14	with	with	IN
cord-283382-t890r7xp	202	15	hematopoietic	hematopoietic	JJ
cord-283382-t890r7xp	202	16	APCs	apc	NNS
cord-283382-t890r7xp	202	17	,	,	,
cord-283382-t890r7xp	202	18	contributes	contribute	VBZ
cord-283382-t890r7xp	202	19	to	to	IN
cord-283382-t890r7xp	202	20	the	the	DT
cord-283382-t890r7xp	202	21	kinetics	kinetic	NNS
cord-283382-t890r7xp	202	22	of	of	IN
cord-283382-t890r7xp	202	23	primary	primary	JJ
cord-283382-t890r7xp	202	24	CD8	CD8	NNP
cord-283382-t890r7xp	202	25	+	+	CC
cord-283382-t890r7xp	202	26	T	T	NNP
cord-283382-t890r7xp	202	27	cell	cell	NN
cord-283382-t890r7xp	202	28	expansion	expansion	NN
cord-283382-t890r7xp	202	29	,	,	,
cord-283382-t890r7xp	202	30	the	the	DT
cord-283382-t890r7xp	202	31	maintenance	maintenance	NN
cord-283382-t890r7xp	202	32	of	of	IN
cord-283382-t890r7xp	202	33	memory	memory	NN
cord-283382-t890r7xp	202	34	responses	response	NNS
cord-283382-t890r7xp	202	35	and	and	CC
cord-283382-t890r7xp	202	36	to	to	IN
cord-283382-t890r7xp	202	37	the	the	DT
cord-283382-t890r7xp	202	38	functional	functional	JJ
cord-283382-t890r7xp	202	39	phenotype	phenotype	NN
cord-283382-t890r7xp	202	40	of	of	IN
cord-283382-t890r7xp	202	41	the	the	DT
cord-283382-t890r7xp	202	42	cellular	cellular	JJ
cord-283382-t890r7xp	202	43	immune	immune	JJ
cord-283382-t890r7xp	202	44	response	response	NN
cord-283382-t890r7xp	202	45	following	follow	VBG
cord-283382-t890r7xp	202	46	Ad	ad	NN
cord-283382-t890r7xp	202	47	vaccination	vaccination	NN
cord-283382-t890r7xp	202	48	(	(	-LRB-
cord-283382-t890r7xp	202	49	39	39	CD
cord-283382-t890r7xp	202	50	)	)	-RRB-
cord-283382-t890r7xp	202	51	.	.	.
cord-283382-t890r7xp	203	1	Through	through	IN
cord-283382-t890r7xp	203	2	a	a	DT
cord-283382-t890r7xp	203	3	series	series	NN
cord-283382-t890r7xp	203	4	of	of	IN
cord-283382-t890r7xp	203	5	investigations	investigation	NNS
cord-283382-t890r7xp	203	6	,	,	,
cord-283382-t890r7xp	203	7	the	the	DT
cord-283382-t890r7xp	203	8	authors	author	NNS
cord-283382-t890r7xp	203	9	showed	show	VBD
cord-283382-t890r7xp	203	10	that	that	IN
cord-283382-t890r7xp	203	11	although	although	IN
cord-283382-t890r7xp	203	12	dLNs	dLNs	NNP
cord-283382-t890r7xp	203	13	act	act	NNP
cord-283382-t890r7xp	203	14	as	as	IN
cord-283382-t890r7xp	203	15	the	the	DT
cord-283382-t890r7xp	203	16	site	site	NN
cord-283382-t890r7xp	203	17	of	of	IN
cord-283382-t890r7xp	203	18	immunological	immunological	JJ
cord-283382-t890r7xp	203	19	priming	priming	NN
cord-283382-t890r7xp	203	20	in	in	IN
cord-283382-t890r7xp	203	21	response	response	NN
cord-283382-t890r7xp	203	22	to	to	IN
cord-283382-t890r7xp	203	23	Ad	ad	NN
cord-283382-t890r7xp	203	24	vaccination	vaccination	NN
cord-283382-t890r7xp	203	25	,	,	,
cord-283382-t890r7xp	203	26	primary	primary	JJ
cord-283382-t890r7xp	203	27	expansion	expansion	NN
cord-283382-t890r7xp	203	28	of	of	IN
cord-283382-t890r7xp	203	29	the	the	DT
cord-283382-t890r7xp	203	30	Ag	Ag	NNP
cord-283382-t890r7xp	203	31	-	-	HYPH
cord-283382-t890r7xp	203	32	specific	specific	JJ
cord-283382-t890r7xp	203	33	CD8	CD8	NNP
cord-283382-t890r7xp	203	34	+	+	CC
cord-283382-t890r7xp	203	35	T	T	NNP
cord-283382-t890r7xp	203	36	cell	cell	NN
cord-283382-t890r7xp	203	37	response	response	NN
cord-283382-t890r7xp	203	38	requires	require	VBZ
cord-283382-t890r7xp	203	39	a	a	DT
cord-283382-t890r7xp	203	40	source	source	NN
cord-283382-t890r7xp	203	41	of	of	IN
cord-283382-t890r7xp	203	42	sustained	sustain	VBN
cord-283382-t890r7xp	203	43	Ag	Ag	NNP
cord-283382-t890r7xp	203	44	expression	expression	NN
cord-283382-t890r7xp	203	45	outside	outside	IN
cord-283382-t890r7xp	203	46	of	of	IN
cord-283382-t890r7xp	203	47	dLNs	dlns	XX
cord-283382-t890r7xp	204	1	(	(	-LRB-
cord-283382-t890r7xp	204	2	39	39	CD
cord-283382-t890r7xp	204	3	)	)	-RRB-
cord-283382-t890r7xp	204	4	.	.	.
cord-283382-t890r7xp	205	1	They	-PRON-	PRP
cord-283382-t890r7xp	205	2	hypothesized	hypothesize	VBD
cord-283382-t890r7xp	205	3	that	that	IN
cord-283382-t890r7xp	205	4	this	this	DT
cord-283382-t890r7xp	205	5	cell	cell	NN
cord-283382-t890r7xp	205	6	type	type	NN
cord-283382-t890r7xp	205	7	was	be	VBD
cord-283382-t890r7xp	205	8	of	of	IN
cord-283382-t890r7xp	205	9	non	non	JJ
cord-283382-t890r7xp	205	10	-	-	JJ
cord-283382-t890r7xp	205	11	hematopoietic	hematopoietic	JJ
cord-283382-t890r7xp	205	12	origin	origin	NN
cord-283382-t890r7xp	205	13	,	,	,
cord-283382-t890r7xp	205	14	due	due	IN
cord-283382-t890r7xp	205	15	to	to	IN
cord-283382-t890r7xp	205	16	their	-PRON-	PRP$
cord-283382-t890r7xp	205	17	prior	prior	JJ
cord-283382-t890r7xp	205	18	findings	finding	NNS
cord-283382-t890r7xp	205	19	that	that	IN
cord-283382-t890r7xp	205	20	a	a	DT
cord-283382-t890r7xp	205	21	radioresistant	radioresistant	NN
cord-283382-t890r7xp	205	22	population	population	NN
cord-283382-t890r7xp	205	23	of	of	IN
cord-283382-t890r7xp	205	24	cells	cell	NNS
cord-283382-t890r7xp	205	25	was	be	VBD
cord-283382-t890r7xp	205	26	capable	capable	JJ
cord-283382-t890r7xp	205	27	of	of	IN
cord-283382-t890r7xp	205	28	priming	prime	VBG
cord-283382-t890r7xp	205	29	CD8	CD8	NNP
cord-283382-t890r7xp	205	30	+	+	CC
cord-283382-t890r7xp	205	31	T	T	NNP
cord-283382-t890r7xp	205	32	cell	cell	NN
cord-283382-t890r7xp	205	33	responses	response	NNS
cord-283382-t890r7xp	205	34	in	in	IN
cord-283382-t890r7xp	205	35	mice	mice	NN
cord-283382-t890r7xp	205	36	leukopenic	leukopenic	JJ
cord-283382-t890r7xp	205	37	mice	mouse	NNS
cord-283382-t890r7xp	205	38	(	(	-LRB-
cord-283382-t890r7xp	205	39	137	137	CD
cord-283382-t890r7xp	205	40	)	)	-RRB-
cord-283382-t890r7xp	205	41	.	.	.
cord-283382-t890r7xp	206	1	Therefore	therefore	RB
cord-283382-t890r7xp	206	2	,	,	,
cord-283382-t890r7xp	206	3	it	-PRON-	PRP
cord-283382-t890r7xp	206	4	is	be	VBZ
cord-283382-t890r7xp	206	5	feasible	feasible	JJ
cord-283382-t890r7xp	206	6	that	that	IN
cord-283382-t890r7xp	206	7	several	several	JJ
cord-283382-t890r7xp	206	8	modes	mode	NNS
cord-283382-t890r7xp	206	9	of	of	IN
cord-283382-t890r7xp	206	10	Ag	Ag	NNP
cord-283382-t890r7xp	206	11	presentation	presentation	NN
cord-283382-t890r7xp	206	12	take	take	VBP
cord-283382-t890r7xp	206	13	place	place	NN
cord-283382-t890r7xp	206	14	following	follow	VBG
cord-283382-t890r7xp	206	15	i.m	i.m	NNP
cord-283382-t890r7xp	206	16	.	.	.
cord-283382-t890r7xp	206	17	immunization	immunization	NN
cord-283382-t890r7xp	206	18	with	with	IN
cord-283382-t890r7xp	206	19	Ad	ad	NN
cord-283382-t890r7xp	206	20	vectors	vector	NNS
cord-283382-t890r7xp	206	21	,	,	,
cord-283382-t890r7xp	206	22	all	all	DT
cord-283382-t890r7xp	206	23	of	of	IN
cord-283382-t890r7xp	206	24	which	which	WDT
cord-283382-t890r7xp	206	25	contribute	contribute	VBP
cord-283382-t890r7xp	206	26	to	to	IN
cord-283382-t890r7xp	206	27	different	different	JJ
cord-283382-t890r7xp	206	28	facets	facet	NNS
cord-283382-t890r7xp	206	29	of	of	IN
cord-283382-t890r7xp	206	30	the	the	DT
cord-283382-t890r7xp	206	31	ensuing	ensue	VBG
cord-283382-t890r7xp	206	32	immune	immune	JJ
cord-283382-t890r7xp	206	33	response	response	NN
cord-283382-t890r7xp	206	34	.	.	.
cord-283382-t890r7xp	207	1	These	these	DT
cord-283382-t890r7xp	207	2	interactions	interaction	NNS
cord-283382-t890r7xp	207	3	are	be	VBP
cord-283382-t890r7xp	207	4	summarized	summarize	VBN
cord-283382-t890r7xp	207	5	in	in	IN
cord-283382-t890r7xp	207	6	Figure	Figure	NNP
cord-283382-t890r7xp	207	7	4	4	CD
cord-283382-t890r7xp	207	8	,	,	,
cord-283382-t890r7xp	207	9	showing	show	VBG
cord-283382-t890r7xp	207	10	that	that	IN
cord-283382-t890r7xp	207	11	Ag	Ag	NNP
cord-283382-t890r7xp	207	12	presentation	presentation	NN
cord-283382-t890r7xp	207	13	could	could	MD
cord-283382-t890r7xp	207	14	take	take	VB
cord-283382-t890r7xp	207	15	place	place	NN
cord-283382-t890r7xp	207	16	not	not	RB
cord-283382-t890r7xp	207	17	only	only	RB
cord-283382-t890r7xp	207	18	within	within	IN
cord-283382-t890r7xp	207	19	dLNs	dlns	XX
cord-283382-t890r7xp	207	20	,	,	,
cord-283382-t890r7xp	207	21	but	but	CC
cord-283382-t890r7xp	207	22	also	also	RB
cord-283382-t890r7xp	207	23	at	at	IN
cord-283382-t890r7xp	207	24	the	the	DT
cord-283382-t890r7xp	207	25	site	site	NN
cord-283382-t890r7xp	207	26	of	of	IN
cord-283382-t890r7xp	207	27	injection	injection	NN
cord-283382-t890r7xp	207	28	,	,	,
cord-283382-t890r7xp	207	29	with	with	IN
cord-283382-t890r7xp	207	30	or	or	CC
cord-283382-t890r7xp	207	31	without	without	IN
cord-283382-t890r7xp	207	32	the	the	DT
cord-283382-t890r7xp	207	33	involvement	involvement	NN
cord-283382-t890r7xp	207	34	of	of	IN
cord-283382-t890r7xp	207	35	professional	professional	JJ
cord-283382-t890r7xp	207	36	APCs	apc	NNS
cord-283382-t890r7xp	207	37	.	.	.
cord-283382-t890r7xp	208	1	It	-PRON-	PRP
cord-283382-t890r7xp	208	2	is	be	VBZ
cord-283382-t890r7xp	208	3	important	important	JJ
cord-283382-t890r7xp	208	4	to	to	TO
cord-283382-t890r7xp	208	5	note	note	VB
cord-283382-t890r7xp	208	6	that	that	IN
cord-283382-t890r7xp	208	7	the	the	DT
cord-283382-t890r7xp	208	8	majority	majority	NN
cord-283382-t890r7xp	208	9	of	of	IN
cord-283382-t890r7xp	208	10	detailed	detailed	JJ
cord-283382-t890r7xp	208	11	mechanistic	mechanistic	JJ
cord-283382-t890r7xp	208	12	studies	study	NNS
cord-283382-t890r7xp	208	13	into	into	IN
cord-283382-t890r7xp	208	14	the	the	DT
cord-283382-t890r7xp	208	15	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	208	16	of	of	IN
cord-283382-t890r7xp	208	17	Ad	ad	NN
cord-283382-t890r7xp	208	18	vectors	vector	NNS
cord-283382-t890r7xp	208	19	have	have	VBP
cord-283382-t890r7xp	208	20	been	be	VBN
cord-283382-t890r7xp	208	21	performed	perform	VBN
cord-283382-t890r7xp	208	22	using	use	VBG
cord-283382-t890r7xp	208	23	Ad5-based	ad5-based	JJ
cord-283382-t890r7xp	208	24	vaccines	vaccine	NNS
cord-283382-t890r7xp	208	25	and	and	CC
cord-283382-t890r7xp	208	26	as	as	RB
cord-283382-t890r7xp	208	27	such	such	JJ
cord-283382-t890r7xp	208	28	,	,	,
cord-283382-t890r7xp	208	29	similar	similar	JJ
cord-283382-t890r7xp	208	30	information	information	NN
cord-283382-t890r7xp	208	31	regarding	regard	VBG
cord-283382-t890r7xp	208	32	the	the	DT
cord-283382-t890r7xp	208	33	in	in	IN
cord-283382-t890r7xp	208	34	vivo	vivo	NN
cord-283382-t890r7xp	208	35	cellular	cellular	JJ
cord-283382-t890r7xp	208	36	tropism	tropism	NN
cord-283382-t890r7xp	208	37	of	of	IN
cord-283382-t890r7xp	208	38	rare	rare	JJ
cord-283382-t890r7xp	208	39	species	specie	NNS
cord-283382-t890r7xp	208	40	or	or	CC
cord-283382-t890r7xp	208	41	non	non	JJ
cord-283382-t890r7xp	208	42	-	-	JJ
cord-283382-t890r7xp	208	43	human	human	JJ
cord-283382-t890r7xp	208	44	Ad	ad	NN
cord-283382-t890r7xp	208	45	vectors	vector	NNS
cord-283382-t890r7xp	208	46	,	,	,
cord-283382-t890r7xp	208	47	is	be	VBZ
cord-283382-t890r7xp	208	48	much	much	RB
cord-283382-t890r7xp	208	49	more	more	RBR
cord-283382-t890r7xp	208	50	limited	limited	JJ
cord-283382-t890r7xp	208	51	(	(	-LRB-
cord-283382-t890r7xp	208	52	123	123	CD
cord-283382-t890r7xp	208	53	)	)	-RRB-
cord-283382-t890r7xp	208	54	.	.	.
cord-283382-t890r7xp	209	1	It	-PRON-	PRP
cord-283382-t890r7xp	209	2	will	will	MD
cord-283382-t890r7xp	209	3	therefore	therefore	RB
cord-283382-t890r7xp	209	4	be	be	VB
cord-283382-t890r7xp	209	5	crucial	crucial	JJ
cord-283382-t890r7xp	209	6	to	to	TO
cord-283382-t890r7xp	209	7	outline	outline	VB
cord-283382-t890r7xp	209	8	the	the	DT
cord-283382-t890r7xp	209	9	precise	precise	JJ
cord-283382-t890r7xp	209	10	factors	factor	NNS
cord-283382-t890r7xp	209	11	which	which	WDT
cord-283382-t890r7xp	209	12	confer	confer	VBP
cord-283382-t890r7xp	209	13	a	a	DT
cord-283382-t890r7xp	209	14	hierarchy	hierarchy	NN
cord-283382-t890r7xp	209	15	of	of	IN
cord-283382-t890r7xp	209	16	potency	potency	NN
cord-283382-t890r7xp	209	17	between	between	IN
cord-283382-t890r7xp	209	18	Ad	ad	NN
cord-283382-t890r7xp	209	19	vectors	vector	NNS
cord-283382-t890r7xp	209	20	in	in	IN
cord-283382-t890r7xp	209	21	the	the	DT
cord-283382-t890r7xp	209	22	future	future	NN
cord-283382-t890r7xp	209	23	,	,	,
cord-283382-t890r7xp	209	24	as	as	IN
cord-283382-t890r7xp	209	25	many	many	JJ
cord-283382-t890r7xp	209	26	Ad	ad	NN
cord-283382-t890r7xp	209	27	vectors	vector	NNS
cord-283382-t890r7xp	209	28	are	be	VBP
cord-283382-t890r7xp	209	29	already	already	RB
cord-283382-t890r7xp	209	30	under	under	IN
cord-283382-t890r7xp	209	31	clinical	clinical	JJ
cord-283382-t890r7xp	209	32	investigation	investigation	NN
cord-283382-t890r7xp	209	33	,	,	,
cord-283382-t890r7xp	209	34	or	or	CC
cord-283382-t890r7xp	209	35	are	be	VBP
cord-283382-t890r7xp	209	36	advancing	advance	VBG
cord-283382-t890r7xp	209	37	rapidly	rapidly	RB
cord-283382-t890r7xp	209	38	into	into	IN
cord-283382-t890r7xp	209	39	clinical	clinical	JJ
cord-283382-t890r7xp	209	40	trials	trial	NNS
cord-283382-t890r7xp	209	41	.	.	.
cord-283382-t890r7xp	210	1	This	this	DT
cord-283382-t890r7xp	210	2	improved	improved	JJ
cord-283382-t890r7xp	210	3	knowledge	knowledge	NN
cord-283382-t890r7xp	210	4	would	would	MD
cord-283382-t890r7xp	210	5	allow	allow	VB
cord-283382-t890r7xp	210	6	us	-PRON-	PRP
cord-283382-t890r7xp	210	7	to	to	TO
cord-283382-t890r7xp	210	8	engineer	engineer	VB
cord-283382-t890r7xp	210	9	optimal	optimal	JJ
cord-283382-t890r7xp	210	10	platform	platform	NN
cord-283382-t890r7xp	210	11	vectors	vector	NNS
cord-283382-t890r7xp	210	12	which	which	WDT
cord-283382-t890r7xp	210	13	combine	combine	VBP
cord-283382-t890r7xp	210	14	multiple	multiple	JJ
cord-283382-t890r7xp	210	15	attributes	attribute	NNS
cord-283382-t890r7xp	210	16	associated	associate	VBN
cord-283382-t890r7xp	210	17	with	with	IN
cord-283382-t890r7xp	210	18	potent	potent	JJ
cord-283382-t890r7xp	210	19	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	210	20	and	and	CC
cord-283382-t890r7xp	210	21	long	long	RB
cord-283382-t890r7xp	210	22	-	-	HYPH
cord-283382-t890r7xp	210	23	lived	live	VBN
cord-283382-t890r7xp	210	24	protective	protective	JJ
cord-283382-t890r7xp	210	25	efficacy	efficacy	NN
cord-283382-t890r7xp	210	26	.	.	.
cord-283382-t890r7xp	211	1	Mucosal	Mucosal	NNP
cord-283382-t890r7xp	211	2	i.n	i.n	NNP
cord-283382-t890r7xp	211	3	.	.	.
cord-283382-t890r7xp	212	1	or	or	CC
cord-283382-t890r7xp	212	2	aerosolized	aerosolize	VBN
cord-283382-t890r7xp	212	3	(	(	-LRB-
cord-283382-t890r7xp	212	4	a.e	a.e	NNP
cord-283382-t890r7xp	212	5	.	.	NNP
cord-283382-t890r7xp	212	6	)	)	-RRB-
cord-283382-t890r7xp	212	7	delivery	delivery	NN
cord-283382-t890r7xp	212	8	of	of	IN
cord-283382-t890r7xp	212	9	Ad	ad	NN
cord-283382-t890r7xp	212	10	vectors	vector	NNS
cord-283382-t890r7xp	212	11	is	be	VBZ
cord-283382-t890r7xp	212	12	particularly	particularly	RB
cord-283382-t890r7xp	212	13	attractive	attractive	JJ
cord-283382-t890r7xp	212	14	for	for	IN
cord-283382-t890r7xp	212	15	the	the	DT
cord-283382-t890r7xp	212	16	development	development	NN
cord-283382-t890r7xp	212	17	of	of	IN
cord-283382-t890r7xp	212	18	vaccines	vaccine	NNS
cord-283382-t890r7xp	212	19	against	against	IN
cord-283382-t890r7xp	212	20	respiratory	respiratory	JJ
cord-283382-t890r7xp	212	21	pathogens	pathogen	NNS
cord-283382-t890r7xp	212	22	(	(	-LRB-
cord-283382-t890r7xp	212	23	108	108	CD
cord-283382-t890r7xp	212	24	,	,	,
cord-283382-t890r7xp	212	25	139	139	CD
cord-283382-t890r7xp	212	26	,	,	,
cord-283382-t890r7xp	212	27	140	140	CD
cord-283382-t890r7xp	212	28	)	)	-RRB-
cord-283382-t890r7xp	212	29	.	.	.
cord-283382-t890r7xp	213	1	Ad	ad	NN
cord-283382-t890r7xp	213	2	vectors	vector	NNS
cord-283382-t890r7xp	213	3	are	be	VBP
cord-283382-t890r7xp	213	4	capable	capable	JJ
cord-283382-t890r7xp	213	5	of	of	IN
cord-283382-t890r7xp	213	6	eliciting	elicit	VBG
cord-283382-t890r7xp	213	7	both	both	DT
cord-283382-t890r7xp	213	8	humoral	humoral	JJ
cord-283382-t890r7xp	213	9	and	and	CC
cord-283382-t890r7xp	213	10	cellular	cellular	JJ
cord-283382-t890r7xp	213	11	immune	immune	JJ
cord-283382-t890r7xp	213	12	responses	response	NNS
cord-283382-t890r7xp	213	13	following	follow	VBG
cord-283382-t890r7xp	214	1	i.n	i.n	NNP
cord-283382-t890r7xp	214	2	.	.	.
cord-283382-t890r7xp	215	1	(	(	-LRB-
cord-283382-t890r7xp	215	2	4	4	CD
cord-283382-t890r7xp	215	3	,	,	,
cord-283382-t890r7xp	215	4	(	(	-LRB-
cord-283382-t890r7xp	215	5	140	140	CD
cord-283382-t890r7xp	215	6	)	)	-RRB-
cord-283382-t890r7xp	215	7	(	(	-LRB-
cord-283382-t890r7xp	215	8	141	141	CD
cord-283382-t890r7xp	215	9	)	)	-RRB-
cord-283382-t890r7xp	215	10	(	(	-LRB-
cord-283382-t890r7xp	215	11	142	142	CD
cord-283382-t890r7xp	215	12	)	)	-RRB-
cord-283382-t890r7xp	215	13	and	and	CC
cord-283382-t890r7xp	215	14	a.e	a.e	NNP
cord-283382-t890r7xp	215	15	.	.	.
cord-283382-t890r7xp	216	1	(	(	-LRB-
cord-283382-t890r7xp	216	2	143	143	CD
cord-283382-t890r7xp	216	3	)	)	-RRB-
cord-283382-t890r7xp	216	4	vaccination	vaccination	NN
cord-283382-t890r7xp	216	5	in	in	IN
cord-283382-t890r7xp	216	6	animal	animal	NN
cord-283382-t890r7xp	216	7	models	model	NNS
cord-283382-t890r7xp	216	8	,	,	,
cord-283382-t890r7xp	216	9	both	both	CC
cord-283382-t890r7xp	216	10	in	in	IN
cord-283382-t890r7xp	216	11	the	the	DT
cord-283382-t890r7xp	216	12	bronchoalveolar	bronchoalveolar	NNP
cord-283382-t890r7xp	216	13	lavage	lavage	NNP
cord-283382-t890r7xp	216	14	(	(	-LRB-
cord-283382-t890r7xp	216	15	BAL	BAL	NNP
cord-283382-t890r7xp	216	16	)	)	-RRB-
cord-283382-t890r7xp	217	1	and	and	CC
cord-283382-t890r7xp	217	2	within	within	IN
cord-283382-t890r7xp	217	3	the	the	DT
cord-283382-t890r7xp	217	4	lung	lung	NNP
cord-283382-t890r7xp	217	5	interstitium	interstitium	NNP
cord-283382-t890r7xp	217	6	(	(	-LRB-
cord-283382-t890r7xp	217	7	15	15	CD
cord-283382-t890r7xp	217	8	,	,	,
cord-283382-t890r7xp	217	9	144	144	CD
cord-283382-t890r7xp	217	10	)	)	-RRB-
cord-283382-t890r7xp	217	11	.	.	.
cord-283382-t890r7xp	218	1	Many	many	JJ
cord-283382-t890r7xp	218	2	wildtype	wildtype	NN
cord-283382-t890r7xp	218	3	adenoviruses	adenovirus	NNS
cord-283382-t890r7xp	218	4	are	be	VBP
cord-283382-t890r7xp	218	5	common	common	JJ
cord-283382-t890r7xp	218	6	respiratory	respiratory	JJ
cord-283382-t890r7xp	218	7	pathogens	pathogen	NNS
cord-283382-t890r7xp	218	8	(	(	-LRB-
cord-283382-t890r7xp	218	9	i.e.	i.e.	FW
cord-283382-t890r7xp	218	10	,	,	,
cord-283382-t890r7xp	218	11	HAdV	HAdV	NNP
cord-283382-t890r7xp	218	12	-	-	HYPH
cord-283382-t890r7xp	218	13	C5	c5	NN
cord-283382-t890r7xp	218	14	,	,	,
cord-283382-t890r7xp	218	15	HAdV	HAdV	NNP
cord-283382-t890r7xp	218	16	-	-	HYPH
cord-283382-t890r7xp	218	17	E4	E4	NNP
cord-283382-t890r7xp	218	18	)	)	-RRB-
cord-283382-t890r7xp	218	19	,	,	,
cord-283382-t890r7xp	218	20	highlighting	highlight	VBG
cord-283382-t890r7xp	218	21	their	-PRON-	PRP$
cord-283382-t890r7xp	218	22	potential	potential	JJ
cord-283382-t890r7xp	218	23	suitability	suitability	NN
cord-283382-t890r7xp	218	24	for	for	IN
cord-283382-t890r7xp	218	25	targeting	target	VBG
cord-283382-t890r7xp	218	26	vaccine	vaccine	NN
cord-283382-t890r7xp	218	27	Ag	Ag	NNP
cord-283382-t890r7xp	218	28	to	to	TO
cord-283382-t890r7xp	218	29	mucosal	mucosal	JJ
cord-283382-t890r7xp	218	30	surfaces	surface	NNS
cord-283382-t890r7xp	218	31	within	within	IN
cord-283382-t890r7xp	218	32	the	the	DT
cord-283382-t890r7xp	218	33	respiratory	respiratory	JJ
cord-283382-t890r7xp	218	34	tract	tract	NN
cord-283382-t890r7xp	218	35	.	.	.
cord-283382-t890r7xp	219	1	However	however	RB
cord-283382-t890r7xp	219	2	,	,	,
cord-283382-t890r7xp	219	3	several	several	JJ
cord-283382-t890r7xp	219	4	chimpanzee	chimpanzee	NN
cord-283382-t890r7xp	219	5	Ad	ad	NN
cord-283382-t890r7xp	219	6	vectors	vector	NNS
cord-283382-t890r7xp	219	7	,	,	,
cord-283382-t890r7xp	219	8	which	which	WDT
cord-283382-t890r7xp	219	9	are	be	VBP
cord-283382-t890r7xp	219	10	not	not	RB
cord-283382-t890r7xp	219	11	associated	associate	VBN
cord-283382-t890r7xp	219	12	with	with	IN
cord-283382-t890r7xp	219	13	respiratory	respiratory	JJ
cord-283382-t890r7xp	219	14	infections	infection	NNS
cord-283382-t890r7xp	219	15	,	,	,
cord-283382-t890r7xp	219	16	have	have	VBP
cord-283382-t890r7xp	219	17	displayed	display	VBN
cord-283382-t890r7xp	219	18	superior	superior	JJ
cord-283382-t890r7xp	219	19	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	219	20	to	to	IN
cord-283382-t890r7xp	219	21	Ad5	Ad5	NNP
cord-283382-t890r7xp	219	22	when	when	WRB
cord-283382-t890r7xp	219	23	Non	non	JJ
cord-283382-t890r7xp	219	24	-	-	JJ
cord-283382-t890r7xp	219	25	professional	professional	JJ
cord-283382-t890r7xp	219	26	APCs	apc	NNS
cord-283382-t890r7xp	219	27	such	such	JJ
cord-283382-t890r7xp	219	28	as	as	IN
cord-283382-t890r7xp	219	29	parenchymal	parenchymal	NN
cord-283382-t890r7xp	219	30	cells	cell	NNS
cord-283382-t890r7xp	219	31	at	at	IN
cord-283382-t890r7xp	219	32	the	the	DT
cord-283382-t890r7xp	219	33	site	site	NN
cord-283382-t890r7xp	219	34	of	of	IN
cord-283382-t890r7xp	219	35	injection	injection	NN
cord-283382-t890r7xp	219	36	(	(	-LRB-
cord-283382-t890r7xp	219	37	muscle	muscle	NN
cord-283382-t890r7xp	219	38	cells	cell	NNS
cord-283382-t890r7xp	219	39	shown	show	VBN
cord-283382-t890r7xp	219	40	as	as	IN
cord-283382-t890r7xp	219	41	an	an	DT
cord-283382-t890r7xp	219	42	example	example	NN
cord-283382-t890r7xp	219	43	)	)	-RRB-
cord-283382-t890r7xp	219	44	can	can	MD
cord-283382-t890r7xp	219	45	present	present	VB
cord-283382-t890r7xp	219	46	antigenic	antigenic	JJ
cord-283382-t890r7xp	219	47	peptide	peptide	NN
cord-283382-t890r7xp	219	48	on	on	IN
cord-283382-t890r7xp	219	49	MHC	MHC	NNP
cord-283382-t890r7xp	219	50	I	-PRON-	PRP
cord-283382-t890r7xp	219	51	to	to	IN
cord-283382-t890r7xp	219	52	infiltrating	infiltrate	VBG
cord-283382-t890r7xp	219	53	CD8	CD8	NNP
cord-283382-t890r7xp	219	54	+	+	CC
cord-283382-t890r7xp	219	55	T	t	NN
cord-283382-t890r7xp	219	56	lymphocytes	lymphocyte	NNS
cord-283382-t890r7xp	219	57	,	,	,
cord-283382-t890r7xp	219	58	outside	outside	RB
cord-283382-t890r7xp	219	59	of	of	IN
cord-283382-t890r7xp	219	60	secondary	secondary	JJ
cord-283382-t890r7xp	219	61	lymphoid	lymphoid	JJ
cord-283382-t890r7xp	219	62	organs	organ	NNS
cord-283382-t890r7xp	219	63	.	.	.
cord-283382-t890r7xp	220	1	Figure	figure	NN
cord-283382-t890r7xp	220	2	is	be	VBZ
cord-283382-t890r7xp	220	3	updated	update	VBN
cord-283382-t890r7xp	220	4	from	from	IN
cord-283382-t890r7xp	220	5	Coughlan	Coughlan	NNP
cord-283382-t890r7xp	220	6	et	et	NNP
cord-283382-t890r7xp	220	7	al	al	NNP
cord-283382-t890r7xp	220	8	.	.	.
cord-283382-t890r7xp	221	1	(	(	-LRB-
cord-283382-t890r7xp	221	2	108	108	CD
cord-283382-t890r7xp	221	3	)	)	-RRB-
cord-283382-t890r7xp	221	4	and	and	CC
cord-283382-t890r7xp	221	5	Holst	Holst	NNP
cord-283382-t890r7xp	221	6	and	and	CC
cord-283382-t890r7xp	221	7	Thomsen	Thomsen	NNP
cord-283382-t890r7xp	221	8	(	(	-LRB-
cord-283382-t890r7xp	221	9	138	138	CD
cord-283382-t890r7xp	221	10	)	)	-RRB-
cord-283382-t890r7xp	222	1	and	and	CC
cord-283382-t890r7xp	222	2	was	be	VBD
cord-283382-t890r7xp	222	3	created	create	VBN
cord-283382-t890r7xp	222	4	with	with	IN
cord-283382-t890r7xp	222	5	©	©	NNP
cord-283382-t890r7xp	222	6	BioRender	BioRender	NNP
cord-283382-t890r7xp	222	7	-biorender.com	-biorender.com	ADD
cord-283382-t890r7xp	222	8	.	.	.
cord-283382-t890r7xp	223	1	administered	administer	VBN
cord-283382-t890r7xp	223	2	by	by	IN
cord-283382-t890r7xp	223	3	the	the	DT
cord-283382-t890r7xp	223	4	i.n	i.n	NNP
cord-283382-t890r7xp	223	5	.	.	NNP
cord-283382-t890r7xp	223	6	route	route	NN
cord-283382-t890r7xp	223	7	in	in	IN
cord-283382-t890r7xp	223	8	mice	mouse	NNS
cord-283382-t890r7xp	223	9	,	,	,
cord-283382-t890r7xp	223	10	including	include	VBG
cord-283382-t890r7xp	223	11	a	a	DT
cord-283382-t890r7xp	223	12	ChAdV-68based	chadv-68base	VBN
cord-283382-t890r7xp	223	13	vaccine	vaccine	NN
cord-283382-t890r7xp	223	14	against	against	IN
cord-283382-t890r7xp	223	15	pulmonary	pulmonary	JJ
cord-283382-t890r7xp	223	16	tuberculosis	tuberculosis	NN
cord-283382-t890r7xp	223	17	(	(	-LRB-
cord-283382-t890r7xp	223	18	TB	TB	NNP
cord-283382-t890r7xp	223	19	)	)	-RRB-
cord-283382-t890r7xp	223	20	(	(	-LRB-
cord-283382-t890r7xp	223	21	144	144	CD
cord-283382-t890r7xp	223	22	)	)	-RRB-
cord-283382-t890r7xp	223	23	and	and	CC
cord-283382-t890r7xp	223	24	a	a	DT
cord-283382-t890r7xp	223	25	ChAdV-7	chadv-7	NN
cord-283382-t890r7xp	223	26	vaccine	vaccine	NN
cord-283382-t890r7xp	223	27	against	against	IN
cord-283382-t890r7xp	223	28	Pseudomonas	Pseudomonas	NNP
cord-283382-t890r7xp	223	29	aeruginosa	aeruginosa	NN
cord-283382-t890r7xp	223	30	(	(	-LRB-
cord-283382-t890r7xp	223	31	145	145	CD
cord-283382-t890r7xp	223	32	)	)	-RRB-
cord-283382-t890r7xp	223	33	.	.	.
cord-283382-t890r7xp	224	1	A	a	DT
cord-283382-t890r7xp	224	2	major	major	JJ
cord-283382-t890r7xp	224	3	limitation	limitation	NN
cord-283382-t890r7xp	224	4	in	in	IN
cord-283382-t890r7xp	224	5	the	the	DT
cord-283382-t890r7xp	224	6	application	application	NN
cord-283382-t890r7xp	224	7	of	of	IN
cord-283382-t890r7xp	224	8	rAd	rAd	NNP
cord-283382-t890r7xp	224	9	vaccines	vaccine	NNS
cord-283382-t890r7xp	224	10	to	to	TO
cord-283382-t890r7xp	224	11	mucosal	mucosal	VB
cord-283382-t890r7xp	224	12	respiratory	respiratory	JJ
cord-283382-t890r7xp	224	13	surfaces	surface	NNS
cord-283382-t890r7xp	224	14	may	may	MD
cord-283382-t890r7xp	224	15	be	be	VB
cord-283382-t890r7xp	224	16	the	the	DT
cord-283382-t890r7xp	224	17	rapid	rapid	JJ
cord-283382-t890r7xp	224	18	scavenging	scavenging	NN
cord-283382-t890r7xp	224	19	and	and	CC
cord-283382-t890r7xp	224	20	degradation	degradation	NN
cord-283382-t890r7xp	224	21	of	of	IN
cord-283382-t890r7xp	224	22	Ad	ad	NN
cord-283382-t890r7xp	224	23	vaccine	vaccine	NN
cord-283382-t890r7xp	224	24	vector	vector	NN
cord-283382-t890r7xp	224	25	particles	particle	NNS
cord-283382-t890r7xp	224	26	by	by	IN
cord-283382-t890r7xp	224	27	tissue	tissue	NN
cord-283382-t890r7xp	224	28	resident	resident	NN
cord-283382-t890r7xp	224	29	alveolar	alveolar	NN
cord-283382-t890r7xp	224	30	macrophages	macrophage	NNS
cord-283382-t890r7xp	224	31	in	in	IN
cord-283382-t890r7xp	224	32	the	the	DT
cord-283382-t890r7xp	224	33	lung	lung	NN
cord-283382-t890r7xp	224	34	,	,	,
cord-283382-t890r7xp	224	35	as	as	IN
cord-283382-t890r7xp	224	36	it	-PRON-	PRP
cord-283382-t890r7xp	224	37	has	have	VBZ
cord-283382-t890r7xp	224	38	previously	previously	RB
cord-283382-t890r7xp	224	39	been	be	VBN
cord-283382-t890r7xp	224	40	estimated	estimate	VBN
cord-283382-t890r7xp	224	41	that	that	IN
cord-283382-t890r7xp	224	42	∼70	∼70	NN
cord-283382-t890r7xp	224	43	%	%	NN
cord-283382-t890r7xp	224	44	of	of	IN
cord-283382-t890r7xp	224	45	Ad	ad	NN
cord-283382-t890r7xp	224	46	vector	vector	NN
cord-283382-t890r7xp	224	47	genomes	genome	NNS
cord-283382-t890r7xp	224	48	are	be	VBP
cord-283382-t890r7xp	224	49	lost	lose	VBN
cord-283382-t890r7xp	224	50	within	within	IN
cord-283382-t890r7xp	224	51	the	the	DT
cord-283382-t890r7xp	224	52	first	first	JJ
cord-283382-t890r7xp	224	53	24h	24h	NNP
cord-283382-t890r7xp	224	54	following	follow	VBG
cord-283382-t890r7xp	224	55	lung	lung	NN
cord-283382-t890r7xp	224	56	delivery	delivery	NN
cord-283382-t890r7xp	224	57	in	in	IN
cord-283382-t890r7xp	224	58	mice	mouse	NNS
cord-283382-t890r7xp	224	59	(	(	-LRB-
cord-283382-t890r7xp	224	60	intratracheal	intratracheal	NN
cord-283382-t890r7xp	224	61	)	)	-RRB-
cord-283382-t890r7xp	224	62	(	(	-LRB-
cord-283382-t890r7xp	224	63	66	66	CD
cord-283382-t890r7xp	224	64	)	)	-RRB-
cord-283382-t890r7xp	224	65	.	.	.
cord-283382-t890r7xp	225	1	Furthermore	furthermore	RB
cord-283382-t890r7xp	225	2	,	,	,
cord-283382-t890r7xp	225	3	alveolar	alveolar	NN
cord-283382-t890r7xp	225	4	macrophages	macrophage	NNS
cord-283382-t890r7xp	225	5	were	be	VBD
cord-283382-t890r7xp	225	6	found	find	VBN
cord-283382-t890r7xp	225	7	to	to	TO
cord-283382-t890r7xp	225	8	be	be	VB
cord-283382-t890r7xp	225	9	the	the	DT
cord-283382-t890r7xp	225	10	predominant	predominant	JJ
cord-283382-t890r7xp	225	11	cell	cell	NN
cord-283382-t890r7xp	225	12	type	type	NN
cord-283382-t890r7xp	225	13	responsible	responsible	JJ
cord-283382-t890r7xp	225	14	for	for	IN
cord-283382-t890r7xp	225	15	initial	initial	JJ
cord-283382-t890r7xp	225	16	inflammatory	inflammatory	JJ
cord-283382-t890r7xp	225	17	cytokine	cytokine	NN
cord-283382-t890r7xp	225	18	induction	induction	NN
cord-283382-t890r7xp	225	19	(	(	-LRB-
cord-283382-t890r7xp	225	20	68	68	CD
cord-283382-t890r7xp	225	21	)	)	-RRB-
cord-283382-t890r7xp	225	22	.	.	.
cord-283382-t890r7xp	226	1	However	however	RB
cord-283382-t890r7xp	226	2	,	,	,
cord-283382-t890r7xp	226	3	depending	depend	VBG
cord-283382-t890r7xp	226	4	on	on	IN
cord-283382-t890r7xp	226	5	the	the	DT
cord-283382-t890r7xp	226	6	balance	balance	NN
cord-283382-t890r7xp	226	7	of	of	IN
cord-283382-t890r7xp	226	8	innate	innate	JJ
cord-283382-t890r7xp	226	9	immune	immune	JJ
cord-283382-t890r7xp	226	10	stimulation	stimulation	NN
cord-283382-t890r7xp	226	11	and	and	CC
cord-283382-t890r7xp	226	12	the	the	DT
cord-283382-t890r7xp	226	13	retention	retention	NN
cord-283382-t890r7xp	226	14	of	of	IN
cord-283382-t890r7xp	226	15	a	a	DT
cord-283382-t890r7xp	226	16	certain	certain	JJ
cord-283382-t890r7xp	226	17	level	level	NN
cord-283382-t890r7xp	226	18	of	of	IN
cord-283382-t890r7xp	226	19	transgene	transgene	JJ
cord-283382-t890r7xp	226	20	expression	expression	NN
cord-283382-t890r7xp	226	21	within	within	IN
cord-283382-t890r7xp	226	22	the	the	DT
cord-283382-t890r7xp	226	23	respiratory	respiratory	JJ
cord-283382-t890r7xp	226	24	tract	tract	NN
cord-283382-t890r7xp	226	25	,	,	,
cord-283382-t890r7xp	226	26	these	these	DT
cord-283382-t890r7xp	226	27	interactions	interaction	NNS
cord-283382-t890r7xp	226	28	could	could	MD
cord-283382-t890r7xp	226	29	be	be	VB
cord-283382-t890r7xp	226	30	beneficial	beneficial	JJ
cord-283382-t890r7xp	226	31	for	for	IN
cord-283382-t890r7xp	226	32	the	the	DT
cord-283382-t890r7xp	226	33	induction	induction	NN
cord-283382-t890r7xp	226	34	of	of	IN
cord-283382-t890r7xp	226	35	subsequent	subsequent	JJ
cord-283382-t890r7xp	226	36	adaptive	adaptive	JJ
cord-283382-t890r7xp	226	37	immune	immune	JJ
cord-283382-t890r7xp	226	38	responses	response	NNS
cord-283382-t890r7xp	226	39	.	.	.
cord-283382-t890r7xp	227	1	Alveolar	alveolar	NN
cord-283382-t890r7xp	227	2	macrophages	macrophage	NNS
cord-283382-t890r7xp	227	3	may	may	MD
cord-283382-t890r7xp	227	4	play	play	VB
cord-283382-t890r7xp	227	5	a	a	DT
cord-283382-t890r7xp	227	6	role	role	NN
cord-283382-t890r7xp	227	7	in	in	IN
cord-283382-t890r7xp	227	8	trafficking	trafficking	NN
cord-283382-t890r7xp	227	9	to	to	IN
cord-283382-t890r7xp	227	10	dLNs	dlns	XX
cord-283382-t890r7xp	227	11	to	to	TO
cord-283382-t890r7xp	227	12	facilitate	facilitate	VB
cord-283382-t890r7xp	227	13	Ag	Ag	NNP
cord-283382-t890r7xp	227	14	priming	priming	NN
cord-283382-t890r7xp	227	15	,	,	,
cord-283382-t890r7xp	227	16	or	or	CC
cord-283382-t890r7xp	227	17	the	the	DT
cord-283382-t890r7xp	227	18	inflammatory	inflammatory	JJ
cord-283382-t890r7xp	227	19	cytokines	cytokine	NNS
cord-283382-t890r7xp	227	20	they	-PRON-	PRP
cord-283382-t890r7xp	227	21	release	release	VBP
cord-283382-t890r7xp	227	22	could	could	MD
cord-283382-t890r7xp	227	23	signal	signal	VB
cord-283382-t890r7xp	227	24	the	the	DT
cord-283382-t890r7xp	227	25	recruitment	recruitment	NN
cord-283382-t890r7xp	227	26	of	of	IN
cord-283382-t890r7xp	227	27	lymphoid	lymphoid	JJ
cord-283382-t890r7xp	227	28	cells	cell	NNS
cord-283382-t890r7xp	227	29	which	which	WDT
cord-283382-t890r7xp	227	30	could	could	MD
cord-283382-t890r7xp	227	31	further	far	RBR
cord-283382-t890r7xp	227	32	potentiate	potentiate	VB
cord-283382-t890r7xp	227	33	immune	immune	JJ
cord-283382-t890r7xp	227	34	responses	response	NNS
cord-283382-t890r7xp	227	35	to	to	IN
cord-283382-t890r7xp	227	36	Ad	ad	NN
cord-283382-t890r7xp	227	37	-	-	HYPH
cord-283382-t890r7xp	227	38	encoded	encode	VBN
cord-283382-t890r7xp	227	39	transgene	transgene	NN
cord-283382-t890r7xp	227	40	Ag	Ag	NNP
cord-283382-t890r7xp	227	41	.	.	.
cord-283382-t890r7xp	228	1	The	the	DT
cord-283382-t890r7xp	228	2	many	many	JJ
cord-283382-t890r7xp	228	3	studies	study	NNS
cord-283382-t890r7xp	228	4	which	which	WDT
cord-283382-t890r7xp	228	5	have	have	VBP
cord-283382-t890r7xp	228	6	confirmed	confirm	VBN
cord-283382-t890r7xp	228	7	the	the	DT
cord-283382-t890r7xp	228	8	induction	induction	NN
cord-283382-t890r7xp	228	9	of	of	IN
cord-283382-t890r7xp	228	10	protective	protective	JJ
cord-283382-t890r7xp	228	11	immunity	immunity	NN
cord-283382-t890r7xp	228	12	following	follow	VBG
cord-283382-t890r7xp	228	13	i.n	i.n	NNP
cord-283382-t890r7xp	228	14	.	.	.
cord-283382-t890r7xp	228	15	vaccination	vaccination	NN
cord-283382-t890r7xp	228	16	with	with	IN
cord-283382-t890r7xp	228	17	Ad	ad	NN
cord-283382-t890r7xp	228	18	vectors	vector	NNS
cord-283382-t890r7xp	228	19	support	support	VBP
cord-283382-t890r7xp	228	20	this	this	DT
cord-283382-t890r7xp	228	21	possibility	possibility	NN
cord-283382-t890r7xp	228	22	,	,	,
cord-283382-t890r7xp	228	23	but	but	CC
cord-283382-t890r7xp	228	24	the	the	DT
cord-283382-t890r7xp	228	25	precise	precise	JJ
cord-283382-t890r7xp	228	26	mechanistic	mechanistic	JJ
cord-283382-t890r7xp	228	27	factors	factor	NNS
cord-283382-t890r7xp	228	28	which	which	WDT
cord-283382-t890r7xp	228	29	underlie	underlie	VBP
cord-283382-t890r7xp	228	30	these	these	DT
cord-283382-t890r7xp	228	31	effects	effect	NNS
cord-283382-t890r7xp	228	32	and	and	CC
cord-283382-t890r7xp	228	33	the	the	DT
cord-283382-t890r7xp	228	34	specific	specific	JJ
cord-283382-t890r7xp	228	35	cell	cell	NN
cord-283382-t890r7xp	228	36	types	type	NNS
cord-283382-t890r7xp	228	37	which	which	WDT
cord-283382-t890r7xp	228	38	contribute	contribute	VBP
cord-283382-t890r7xp	228	39	to	to	IN
cord-283382-t890r7xp	228	40	vaccine	vaccine	NN
cord-283382-t890r7xp	228	41	efficacy	efficacy	NN
cord-283382-t890r7xp	228	42	are	be	VBP
cord-283382-t890r7xp	228	43	not	not	RB
cord-283382-t890r7xp	228	44	extensively	extensively	RB
cord-283382-t890r7xp	228	45	described	describe	VBN
cord-283382-t890r7xp	228	46	.	.	.
cord-283382-t890r7xp	229	1	As	as	IN
cord-283382-t890r7xp	229	2	differences	difference	NNS
cord-283382-t890r7xp	229	3	in	in	IN
cord-283382-t890r7xp	229	4	the	the	DT
cord-283382-t890r7xp	229	5	phenotype	phenotype	NN
cord-283382-t890r7xp	229	6	and	and	CC
cord-283382-t890r7xp	229	7	trafficking	trafficking	NN
cord-283382-t890r7xp	229	8	potential	potential	NN
cord-283382-t890r7xp	229	9	of	of	IN
cord-283382-t890r7xp	229	10	CD8	CD8	NNP
cord-283382-t890r7xp	229	11	+	+	CC
cord-283382-t890r7xp	229	12	T	T	NNP
cord-283382-t890r7xp	229	13	cells	cell	NNS
cord-283382-t890r7xp	229	14	has	have	VBZ
cord-283382-t890r7xp	229	15	been	be	VBN
cord-283382-t890r7xp	229	16	observed	observe	VBN
cord-283382-t890r7xp	229	17	when	when	WRB
cord-283382-t890r7xp	229	18	comparing	compare	VBG
cord-283382-t890r7xp	229	19	i.m	i.m	NNP
cord-283382-t890r7xp	229	20	.	.	NNP
cord-283382-t890r7xp	229	21	vs.	vs.	FW
cord-283382-t890r7xp	229	22	i.n	i.n	NNP
cord-283382-t890r7xp	229	23	.	.	NNP
cord-283382-t890r7xp	229	24	vaccination	vaccination	NN
cord-283382-t890r7xp	229	25	of	of	IN
cord-283382-t890r7xp	229	26	mice	mouse	NNS
cord-283382-t890r7xp	229	27	with	with	IN
cord-283382-t890r7xp	229	28	Ad	ad	NN
cord-283382-t890r7xp	229	29	vectors	vector	NNS
cord-283382-t890r7xp	229	30	,	,	,
cord-283382-t890r7xp	229	31	it	-PRON-	PRP
cord-283382-t890r7xp	229	32	will	will	MD
cord-283382-t890r7xp	229	33	be	be	VB
cord-283382-t890r7xp	229	34	important	important	JJ
cord-283382-t890r7xp	229	35	to	to	TO
cord-283382-t890r7xp	229	36	identify	identify	VB
cord-283382-t890r7xp	229	37	the	the	DT
cord-283382-t890r7xp	229	38	optimal	optimal	JJ
cord-283382-t890r7xp	229	39	Ad	ad	NN
cord-283382-t890r7xp	229	40	vaccine	vaccine	NN
cord-283382-t890r7xp	229	41	platform	platform	NN
cord-283382-t890r7xp	229	42	which	which	WDT
cord-283382-t890r7xp	229	43	elicits	elicit	VBZ
cord-283382-t890r7xp	229	44	the	the	DT
cord-283382-t890r7xp	229	45	correct	correct	JJ
cord-283382-t890r7xp	229	46	correlates	correlate	NNS
cord-283382-t890r7xp	229	47	of	of	IN
cord-283382-t890r7xp	229	48	protection	protection	NN
cord-283382-t890r7xp	229	49	for	for	IN
cord-283382-t890r7xp	229	50	a	a	DT
cord-283382-t890r7xp	229	51	specific	specific	JJ
cord-283382-t890r7xp	229	52	disease	disease	NN
cord-283382-t890r7xp	229	53	target	target	NN
cord-283382-t890r7xp	229	54	,	,	,
cord-283382-t890r7xp	229	55	before	before	IN
cord-283382-t890r7xp	229	56	deciding	decide	VBG
cord-283382-t890r7xp	229	57	on	on	IN
cord-283382-t890r7xp	229	58	the	the	DT
cord-283382-t890r7xp	229	59	ideal	ideal	JJ
cord-283382-t890r7xp	229	60	route	route	NN
cord-283382-t890r7xp	229	61	of	of	IN
cord-283382-t890r7xp	229	62	vaccine	vaccine	NN
cord-283382-t890r7xp	229	63	administration	administration	NN
cord-283382-t890r7xp	229	64	(	(	-LRB-
cord-283382-t890r7xp	229	65	128	128	CD
cord-283382-t890r7xp	229	66	)	)	-RRB-
cord-283382-t890r7xp	229	67	.	.	.
cord-283382-t890r7xp	230	1	The	the	DT
cord-283382-t890r7xp	230	2	ability	ability	NN
cord-283382-t890r7xp	230	3	to	to	TO
cord-283382-t890r7xp	230	4	engage	engage	VB
cord-283382-t890r7xp	230	5	and	and	CC
cord-283382-t890r7xp	230	6	activate	activate	VB
cord-283382-t890r7xp	230	7	multiple	multiple	JJ
cord-283382-t890r7xp	230	8	,	,	,
cord-283382-t890r7xp	230	9	diverse	diverse	JJ
cord-283382-t890r7xp	230	10	innate	innate	JJ
cord-283382-t890r7xp	230	11	immune	immune	JJ
cord-283382-t890r7xp	230	12	signaling	signal	VBG
cord-283382-t890r7xp	230	13	pathways	pathway	NNS
cord-283382-t890r7xp	230	14	simultaneously	simultaneously	RB
cord-283382-t890r7xp	230	15	(	(	-LRB-
cord-283382-t890r7xp	230	16	excluding	exclude	VBG
cord-283382-t890r7xp	230	17	Type	type	NN
cord-283382-t890r7xp	230	18	I	-PRON-	PRP
cord-283382-t890r7xp	230	19	IFN	IFN	NNP
cord-283382-t890r7xp	230	20	)	)	-RRB-
cord-283382-t890r7xp	230	21	can	can	MD
cord-283382-t890r7xp	230	22	allow	allow	VB
cord-283382-t890r7xp	230	23	rAd	rad	NN
cord-283382-t890r7xp	230	24	vectors	vector	NNS
cord-283382-t890r7xp	230	25	to	to	TO
cord-283382-t890r7xp	230	26	act	act	VB
cord-283382-t890r7xp	230	27	as	as	IN
cord-283382-t890r7xp	230	28	an	an	DT
cord-283382-t890r7xp	230	29	effective	effective	JJ
cord-283382-t890r7xp	230	30	selfadjuvant	selfadjuvant	NN
cord-283382-t890r7xp	230	31	,	,	,
cord-283382-t890r7xp	230	32	relative	relative	JJ
cord-283382-t890r7xp	230	33	to	to	IN
cord-283382-t890r7xp	230	34	other	other	JJ
cord-283382-t890r7xp	230	35	vaccination	vaccination	NN
cord-283382-t890r7xp	230	36	platforms	platform	NNS
cord-283382-t890r7xp	230	37	(	(	-LRB-
cord-283382-t890r7xp	230	38	109	109	CD
cord-283382-t890r7xp	230	39	,	,	,
cord-283382-t890r7xp	230	40	110	110	CD
cord-283382-t890r7xp	230	41	,	,	,
cord-283382-t890r7xp	230	42	146	146	CD
cord-283382-t890r7xp	230	43	)	)	-RRB-
cord-283382-t890r7xp	230	44	.	.	.
cord-283382-t890r7xp	231	1	These	these	DT
cord-283382-t890r7xp	231	2	attributes	attribute	NNS
cord-283382-t890r7xp	231	3	suggest	suggest	VBP
cord-283382-t890r7xp	231	4	that	that	IN
cord-283382-t890r7xp	231	5	Ad	ad	NN
cord-283382-t890r7xp	231	6	virions	virion	NNS
cord-283382-t890r7xp	231	7	themselves	-PRON-	PRP
cord-283382-t890r7xp	231	8	possess	possess	VBP
cord-283382-t890r7xp	231	9	several	several	JJ
cord-283382-t890r7xp	231	10	PAMPs	pamp	NNS
cord-283382-t890r7xp	231	11	.	.	.
cord-283382-t890r7xp	232	1	In	in	IN
cord-283382-t890r7xp	232	2	fact	fact	NN
cord-283382-t890r7xp	232	3	,	,	,
cord-283382-t890r7xp	232	4	it	-PRON-	PRP
cord-283382-t890r7xp	232	5	is	be	VBZ
cord-283382-t890r7xp	232	6	considered	consider	VBN
cord-283382-t890r7xp	232	7	that	that	IN
cord-283382-t890r7xp	232	8	the	the	DT
cord-283382-t890r7xp	232	9	native	native	JJ
cord-283382-t890r7xp	232	10	receptor	receptor	NN
cord-283382-t890r7xp	232	11	determinants	determinant	NNS
cord-283382-t890r7xp	232	12	or	or	CC
cord-283382-t890r7xp	232	13	entry	entry	NN
cord-283382-t890r7xp	232	14	factors	factor	NNS
cord-283382-t890r7xp	232	15	of	of	IN
cord-283382-t890r7xp	232	16	a	a	DT
cord-283382-t890r7xp	232	17	particular	particular	JJ
cord-283382-t890r7xp	232	18	Ad	ad	NN
cord-283382-t890r7xp	232	19	vector	vector	NN
cord-283382-t890r7xp	232	20	may	may	MD
cord-283382-t890r7xp	232	21	,	,	,
cord-283382-t890r7xp	232	22	at	at	IN
cord-283382-t890r7xp	232	23	least	least	JJS
cord-283382-t890r7xp	232	24	in	in	IN
cord-283382-t890r7xp	232	25	part	part	NN
cord-283382-t890r7xp	232	26	,	,	,
cord-283382-t890r7xp	232	27	regulate	regulate	VB
cord-283382-t890r7xp	232	28	innate	innate	JJ
cord-283382-t890r7xp	232	29	immune	immune	JJ
cord-283382-t890r7xp	232	30	activation	activation	NN
cord-283382-t890r7xp	232	31	.	.	.
cord-283382-t890r7xp	233	1	In	in	IN
cord-283382-t890r7xp	233	2	support	support	NN
cord-283382-t890r7xp	233	3	of	of	IN
cord-283382-t890r7xp	233	4	this	this	DT
cord-283382-t890r7xp	233	5	,	,	,
cord-283382-t890r7xp	233	6	binding	bind	VBG
cord-283382-t890r7xp	233	7	of	of	IN
cord-283382-t890r7xp	233	8	the	the	DT
cord-283382-t890r7xp	233	9	fiber	fiber	NN
cord-283382-t890r7xp	233	10	knob	knob	NN
cord-283382-t890r7xp	233	11	domain	domain	NN
cord-283382-t890r7xp	233	12	to	to	IN
cord-283382-t890r7xp	233	13	CAR	car	NN
cord-283382-t890r7xp	233	14	is	be	VBZ
cord-283382-t890r7xp	233	15	sufficient	sufficient	JJ
cord-283382-t890r7xp	233	16	to	to	TO
cord-283382-t890r7xp	233	17	activate	activate	VB
cord-283382-t890r7xp	233	18	p38MAPK	p38MAPK	NNPS
cord-283382-t890r7xp	233	19	,	,	,
cord-283382-t890r7xp	233	20	p44/42MAPK	p44/42mapk	JJ
cord-283382-t890r7xp	233	21	(	(	-LRB-
cord-283382-t890r7xp	233	22	ERK1/2	ERK1/2	NNP
cord-283382-t890r7xp	233	23	)	)	-RRB-
cord-283382-t890r7xp	233	24	,	,	,
cord-283382-t890r7xp	233	25	and	and	CC
cord-283382-t890r7xp	233	26	NF	nf	NN
cord-283382-t890r7xp	233	27	-	-	HYPH
cord-283382-t890r7xp	233	28	κB	κB	NNP
cord-283382-t890r7xp	233	29	pathways	pathway	NNS
cord-283382-t890r7xp	233	30	(	(	-LRB-
cord-283382-t890r7xp	233	31	147	147	CD
cord-283382-t890r7xp	233	32	)	)	-RRB-
cord-283382-t890r7xp	233	33	,	,	,
cord-283382-t890r7xp	233	34	resulting	result	VBG
cord-283382-t890r7xp	233	35	in	in	IN
cord-283382-t890r7xp	233	36	the	the	DT
cord-283382-t890r7xp	233	37	transcription	transcription	NN
cord-283382-t890r7xp	233	38	of	of	IN
cord-283382-t890r7xp	233	39	proinflammatory	proinflammatory	JJ
cord-283382-t890r7xp	233	40	cytokines	cytokine	NNS
cord-283382-t890r7xp	233	41	both	both	DT
cord-283382-t890r7xp	233	42	in	in	IN
cord-283382-t890r7xp	233	43	vitro	vitro	FW
cord-283382-t890r7xp	233	44	and	and	CC
cord-283382-t890r7xp	233	45	in	in	IN
cord-283382-t890r7xp	233	46	vivo	vivo	NNP
cord-283382-t890r7xp	233	47	(	(	-LRB-
cord-283382-t890r7xp	233	48	148	148	CD
cord-283382-t890r7xp	233	49	)	)	-RRB-
cord-283382-t890r7xp	233	50	.	.	.
cord-283382-t890r7xp	234	1	Similarly	similarly	RB
cord-283382-t890r7xp	234	2	,	,	,
cord-283382-t890r7xp	234	3	Ad	ad	NN
cord-283382-t890r7xp	234	4	vectors	vector	NNS
cord-283382-t890r7xp	234	5	which	which	WDT
cord-283382-t890r7xp	234	6	are	be	VBP
cord-283382-t890r7xp	234	7	capable	capable	JJ
cord-283382-t890r7xp	234	8	of	of	IN
cord-283382-t890r7xp	234	9	using	use	VBG
cord-283382-t890r7xp	234	10	CD46	CD46	NNP
cord-283382-t890r7xp	234	11	as	as	IN
cord-283382-t890r7xp	234	12	a	a	DT
cord-283382-t890r7xp	234	13	receptor	receptor	NN
cord-283382-t890r7xp	234	14	have	have	VBP
cord-283382-t890r7xp	234	15	been	be	VBN
cord-283382-t890r7xp	234	16	shown	show	VBN
cord-283382-t890r7xp	234	17	to	to	TO
cord-283382-t890r7xp	234	18	display	display	VB
cord-283382-t890r7xp	234	19	preferential	preferential	JJ
cord-283382-t890r7xp	234	20	activation	activation	NN
cord-283382-t890r7xp	234	21	of	of	IN
cord-283382-t890r7xp	234	22	TLR9	TLR9	NNP
cord-283382-t890r7xp	234	23	to	to	IN
cord-283382-t890r7xp	234	24	CARbinding	carbinde	VBG
cord-283382-t890r7xp	234	25	Ad	ad	NN
cord-283382-t890r7xp	234	26	vectors	vector	NNS
cord-283382-t890r7xp	234	27	in	in	IN
cord-283382-t890r7xp	234	28	vitro	vitro	FW
cord-283382-t890r7xp	234	29	(	(	-LRB-
cord-283382-t890r7xp	234	30	61	61	CD
cord-283382-t890r7xp	234	31	)	)	-RRB-
cord-283382-t890r7xp	234	32	.	.	.
cord-283382-t890r7xp	235	1	However	however	RB
cord-283382-t890r7xp	235	2	,	,	,
cord-283382-t890r7xp	235	3	CD46	CD46	NNP
cord-283382-t890r7xp	235	4	distribution	distribution	NN
cord-283382-t890r7xp	235	5	is	be	VBZ
cord-283382-t890r7xp	235	6	limited	limit	VBN
cord-283382-t890r7xp	235	7	to	to	IN
cord-283382-t890r7xp	235	8	the	the	DT
cord-283382-t890r7xp	235	9	expression	expression	NN
cord-283382-t890r7xp	235	10	in	in	IN
cord-283382-t890r7xp	235	11	the	the	DT
cord-283382-t890r7xp	235	12	testes	testis	NNS
cord-283382-t890r7xp	235	13	in	in	IN
cord-283382-t890r7xp	235	14	mice	mouse	NNS
cord-283382-t890r7xp	235	15	,	,	,
cord-283382-t890r7xp	235	16	rats	rat	NNS
cord-283382-t890r7xp	235	17	and	and	CC
cord-283382-t890r7xp	235	18	guinea	guinea	NN
cord-283382-t890r7xp	235	19	pigs	pig	NNS
cord-283382-t890r7xp	235	20	,	,	,
cord-283382-t890r7xp	235	21	in	in	IN
cord-283382-t890r7xp	235	22	contrast	contrast	NN
cord-283382-t890r7xp	235	23	to	to	IN
cord-283382-t890r7xp	235	24	its	-PRON-	PRP$
cord-283382-t890r7xp	235	25	widespread	widespread	JJ
cord-283382-t890r7xp	235	26	expression	expression	NN
cord-283382-t890r7xp	235	27	in	in	IN
cord-283382-t890r7xp	235	28	humans	human	NNS
cord-283382-t890r7xp	235	29	(	(	-LRB-
cord-283382-t890r7xp	235	30	149	149	CD
cord-283382-t890r7xp	235	31	)	)	-RRB-
cord-283382-t890r7xp	235	32	.	.	.
cord-283382-t890r7xp	236	1	Therefore	therefore	RB
cord-283382-t890r7xp	236	2	,	,	,
cord-283382-t890r7xp	236	3	this	this	DT
cord-283382-t890r7xp	236	4	likely	likely	RB
cord-283382-t890r7xp	236	5	has	have	VBZ
cord-283382-t890r7xp	236	6	little	little	JJ
cord-283382-t890r7xp	236	7	contribution	contribution	NN
cord-283382-t890r7xp	236	8	to	to	IN
cord-283382-t890r7xp	236	9	the	the	DT
cord-283382-t890r7xp	236	10	immunological	immunological	JJ
cord-283382-t890r7xp	236	11	potency	potency	NN
cord-283382-t890r7xp	236	12	of	of	IN
cord-283382-t890r7xp	236	13	CD46-using	CD46-using	NNP
cord-283382-t890r7xp	236	14	Ad	ad	NN
cord-283382-t890r7xp	236	15	vectors	vector	NNS
cord-283382-t890r7xp	236	16	in	in	IN
cord-283382-t890r7xp	236	17	murine	murine	JJ
cord-283382-t890r7xp	236	18	models	model	NNS
cord-283382-t890r7xp	236	19	.	.	.
cord-283382-t890r7xp	237	1	The	the	DT
cord-283382-t890r7xp	237	2	fiber	fiber	NN
cord-283382-t890r7xp	237	3	knob	knob	NN
cord-283382-t890r7xp	237	4	domain	domain	NN
cord-283382-t890r7xp	237	5	of	of	IN
cord-283382-t890r7xp	237	6	Ad5-based	ad5-based	JJ
cord-283382-t890r7xp	237	7	vectors	vector	NNS
cord-283382-t890r7xp	237	8	has	have	VBZ
cord-283382-t890r7xp	237	9	been	be	VBN
cord-283382-t890r7xp	237	10	shown	show	VBN
cord-283382-t890r7xp	237	11	to	to	TO
cord-283382-t890r7xp	237	12	contribute	contribute	VB
cord-283382-t890r7xp	237	13	to	to	IN
cord-283382-t890r7xp	237	14	the	the	DT
cord-283382-t890r7xp	237	15	maturation	maturation	NN
cord-283382-t890r7xp	237	16	of	of	IN
cord-283382-t890r7xp	237	17	murine	murine	JJ
cord-283382-t890r7xp	237	18	DCs	dc	NNS
cord-283382-t890r7xp	237	19	,	,	,
cord-283382-t890r7xp	237	20	as	as	IN
cord-283382-t890r7xp	237	21	recombinant	recombinant	JJ
cord-283382-t890r7xp	237	22	knob	knob	NN
cord-283382-t890r7xp	237	23	protein	protein	NN
cord-283382-t890r7xp	237	24	,	,	,
cord-283382-t890r7xp	237	25	full	full	JJ
cord-283382-t890r7xp	237	26	-	-	HYPH
cord-283382-t890r7xp	237	27	length	length	NN
cord-283382-t890r7xp	237	28	fiber	fiber	NN
cord-283382-t890r7xp	237	29	protein	protein	NN
cord-283382-t890r7xp	237	30	and	and	CC
cord-283382-t890r7xp	237	31	penton	penton	NNP
cord-283382-t890r7xp	237	32	capsomers	capsomers	NNP
cord-283382-t890r7xp	237	33	(	(	-LRB-
cord-283382-t890r7xp	237	34	penton	penton	NNP
cord-283382-t890r7xp	237	35	plus	plus	CC
cord-283382-t890r7xp	237	36	fiber	fiber	NNP
cord-283382-t890r7xp	237	37	)	)	-RRB-
cord-283382-t890r7xp	237	38	,	,	,
cord-283382-t890r7xp	237	39	but	but	CC
cord-283382-t890r7xp	237	40	not	not	RB
cord-283382-t890r7xp	237	41	hexon	hexon	NNP
cord-283382-t890r7xp	237	42	or	or	CC
cord-283382-t890r7xp	237	43	penton	penton	NNP
cord-283382-t890r7xp	237	44	alone	alone	RB
cord-283382-t890r7xp	237	45	,	,	,
cord-283382-t890r7xp	237	46	were	be	VBD
cord-283382-t890r7xp	237	47	capable	capable	JJ
cord-283382-t890r7xp	237	48	of	of	IN
cord-283382-t890r7xp	237	49	exerting	exert	VBG
cord-283382-t890r7xp	237	50	this	this	DT
cord-283382-t890r7xp	237	51	effect	effect	NN
cord-283382-t890r7xp	237	52	(	(	-LRB-
cord-283382-t890r7xp	237	53	90	90	CD
cord-283382-t890r7xp	237	54	)	)	-RRB-
cord-283382-t890r7xp	237	55	.	.	.
cord-283382-t890r7xp	238	1	In	in	IN
cord-283382-t890r7xp	238	2	support	support	NN
cord-283382-t890r7xp	238	3	of	of	IN
cord-283382-t890r7xp	238	4	this	this	DT
cord-283382-t890r7xp	238	5	,	,	,
cord-283382-t890r7xp	238	6	Teigler	Teigler	NNP
cord-283382-t890r7xp	238	7	et	et	NNP
cord-283382-t890r7xp	238	8	al	al	NNP
cord-283382-t890r7xp	238	9	.	.	.
cord-283382-t890r7xp	239	1	previously	previously	RB
cord-283382-t890r7xp	239	2	suggested	suggest	VBD
cord-283382-t890r7xp	239	3	that	that	IN
cord-283382-t890r7xp	239	4	fiber	fiber	NN
cord-283382-t890r7xp	239	5	-	-	HYPH
cord-283382-t890r7xp	239	6	receptor	receptor	NN
cord-283382-t890r7xp	239	7	interactions	interaction	NNS
cord-283382-t890r7xp	239	8	were	be	VBD
cord-283382-t890r7xp	239	9	important	important	JJ
cord-283382-t890r7xp	239	10	for	for	IN
cord-283382-t890r7xp	239	11	triggering	trigger	VBG
cord-283382-t890r7xp	239	12	innate	innate	JJ
cord-283382-t890r7xp	239	13	immune	immune	JJ
cord-283382-t890r7xp	239	14	responses	response	NNS
cord-283382-t890r7xp	239	15	to	to	IN
cord-283382-t890r7xp	239	16	rare	rare	JJ
cord-283382-t890r7xp	239	17	species	specie	NNS
cord-283382-t890r7xp	240	1	Ad	ad	NN
cord-283382-t890r7xp	240	2	vectors	vector	NNS
cord-283382-t890r7xp	240	3	(	(	-LRB-
cord-283382-t890r7xp	240	4	26	26	CD
cord-283382-t890r7xp	240	5	)	)	-RRB-
cord-283382-t890r7xp	240	6	.	.	.
cord-283382-t890r7xp	241	1	Furthermore	furthermore	RB
cord-283382-t890r7xp	241	2	,	,	,
cord-283382-t890r7xp	241	3	studies	study	NNS
cord-283382-t890r7xp	241	4	using	use	VBG
cord-283382-t890r7xp	241	5	HAdV	HAdV	NNP
cord-283382-t890r7xp	241	6	-	-	HYPH
cord-283382-t890r7xp	241	7	B35	B35	NNP
cord-283382-t890r7xp	241	8	vectors	vector	NNS
cord-283382-t890r7xp	241	9	pseudotyped	pseudotyped	NNS
cord-283382-t890r7xp	241	10	with	with	IN
cord-283382-t890r7xp	241	11	the	the	DT
cord-283382-t890r7xp	241	12	fiber	fiber	NN
cord-283382-t890r7xp	241	13	knob	knob	NN
cord-283382-t890r7xp	241	14	from	from	IN
cord-283382-t890r7xp	241	15	Ad5	Ad5	NNP
cord-283382-t890r7xp	241	16	were	be	VBD
cord-283382-t890r7xp	241	17	shown	show	VBN
cord-283382-t890r7xp	241	18	to	to	TO
cord-283382-t890r7xp	241	19	be	be	VB
cord-283382-t890r7xp	241	20	more	more	RBR
cord-283382-t890r7xp	241	21	immunogenic	immunogenic	JJ
cord-283382-t890r7xp	241	22	in	in	IN
cord-283382-t890r7xp	241	23	mice	mouse	NNS
cord-283382-t890r7xp	241	24	and	and	CC
cord-283382-t890r7xp	241	25	NHP	NHP	NNP
cord-283382-t890r7xp	241	26	,	,	,
cord-283382-t890r7xp	241	27	suggesting	suggest	VBG
cord-283382-t890r7xp	241	28	that	that	IN
cord-283382-t890r7xp	241	29	the	the	DT
cord-283382-t890r7xp	241	30	fiber	fiber	NN
cord-283382-t890r7xp	241	31	knob	knob	NN
cord-283382-t890r7xp	241	32	domain	domain	NN
cord-283382-t890r7xp	241	33	could	could	MD
cord-283382-t890r7xp	241	34	contribute	contribute	VB
cord-283382-t890r7xp	241	35	substantially	substantially	RB
cord-283382-t890r7xp	241	36	to	to	IN
cord-283382-t890r7xp	241	37	immunological	immunological	JJ
cord-283382-t890r7xp	241	38	potency	potency	NN
cord-283382-t890r7xp	241	39	(	(	-LRB-
cord-283382-t890r7xp	241	40	150	150	CD
cord-283382-t890r7xp	241	41	)	)	-RRB-
cord-283382-t890r7xp	241	42	.	.	.
cord-283382-t890r7xp	242	1	However	however	RB
cord-283382-t890r7xp	242	2	,	,	,
cord-283382-t890r7xp	242	3	similar	similar	JJ
cord-283382-t890r7xp	242	4	studies	study	NNS
cord-283382-t890r7xp	242	5	in	in	IN
cord-283382-t890r7xp	242	6	which	which	WDT
cord-283382-t890r7xp	242	7	the	the	DT
cord-283382-t890r7xp	242	8	entire	entire	JJ
cord-283382-t890r7xp	242	9	fiber	fiber	NN
cord-283382-t890r7xp	242	10	and	and	CC
cord-283382-t890r7xp	242	11	penton	penton	NNP
cord-283382-t890r7xp	242	12	RGD	RGD	NNP
cord-283382-t890r7xp	242	13	motif	motif	NN
cord-283382-t890r7xp	242	14	from	from	IN
cord-283382-t890r7xp	242	15	rAd5	rAd5	NNPS
cord-283382-t890r7xp	242	16	were	be	VBD
cord-283382-t890r7xp	242	17	swapped	swap	VBN
cord-283382-t890r7xp	242	18	into	into	IN
cord-283382-t890r7xp	242	19	chimpanzee	chimpanzee	NN
cord-283382-t890r7xp	242	20	Ad	ad	NN
cord-283382-t890r7xp	242	21	vector	vector	NN
cord-283382-t890r7xp	242	22	ChAdOx1	ChAdOx1	NNP
cord-283382-t890r7xp	242	23	,	,	,
cord-283382-t890r7xp	242	24	failed	fail	VBD
cord-283382-t890r7xp	242	25	to	to	TO
cord-283382-t890r7xp	242	26	increase	increase	VB
cord-283382-t890r7xp	242	27	the	the	DT
cord-283382-t890r7xp	242	28	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	242	29	of	of	IN
cord-283382-t890r7xp	242	30	ChAdOx1	ChAdOx1	NNP
cord-283382-t890r7xp	242	31	relative	relative	JJ
cord-283382-t890r7xp	242	32	to	to	IN
cord-283382-t890r7xp	242	33	Ad5	ad5	CD
cord-283382-t890r7xp	242	34	,	,	,
cord-283382-t890r7xp	242	35	suggesting	suggest	VBG
cord-283382-t890r7xp	242	36	that	that	IN
cord-283382-t890r7xp	242	37	factors	factor	NNS
cord-283382-t890r7xp	242	38	beyond	beyond	IN
cord-283382-t890r7xp	242	39	fiber	fiber	NN
cord-283382-t890r7xp	242	40	/	/	SYM
cord-283382-t890r7xp	242	41	penton	penton	NNP
cord-283382-t890r7xp	242	42	capsomer	capsomer	NNP
cord-283382-t890r7xp	242	43	interactions	interaction	NNS
cord-283382-t890r7xp	242	44	confer	confer	VBP
cord-283382-t890r7xp	242	45	immune	immune	JJ
cord-283382-t890r7xp	242	46	responses	response	NNS
cord-283382-t890r7xp	242	47	to	to	IN
cord-283382-t890r7xp	242	48	ChAdOx1	ChAdOx1	NNP
cord-283382-t890r7xp	242	49	(	(	-LRB-
cord-283382-t890r7xp	242	50	123	123	CD
cord-283382-t890r7xp	242	51	)	)	-RRB-
cord-283382-t890r7xp	242	52	.	.	.
cord-283382-t890r7xp	243	1	More	more	RBR
cord-283382-t890r7xp	243	2	recently	recently	RB
cord-283382-t890r7xp	243	3	it	-PRON-	PRP
cord-283382-t890r7xp	243	4	has	have	VBZ
cord-283382-t890r7xp	243	5	been	be	VBN
cord-283382-t890r7xp	243	6	shown	show	VBN
cord-283382-t890r7xp	243	7	that	that	IN
cord-283382-t890r7xp	243	8	a	a	DT
cord-283382-t890r7xp	243	9	member	member	NN
cord-283382-t890r7xp	243	10	of	of	IN
cord-283382-t890r7xp	243	11	the	the	DT
cord-283382-t890r7xp	243	12	vitamin	vitamin	NN
cord-283382-t890r7xp	243	13	-	-	HYPH
cord-283382-t890r7xp	243	14	K	k	NN
cord-283382-t890r7xp	243	15	dependent	dependent	JJ
cord-283382-t890r7xp	243	16	protein	protein	NN
cord-283382-t890r7xp	243	17	family	family	NN
cord-283382-t890r7xp	243	18	,	,	,
cord-283382-t890r7xp	243	19	growth	growth	NN
cord-283382-t890r7xp	243	20	arrest	arrest	VBP
cord-283382-t890r7xp	243	21	specific	specific	JJ
cord-283382-t890r7xp	243	22	protein	protein	NN
cord-283382-t890r7xp	243	23	(	(	-LRB-
cord-283382-t890r7xp	243	24	Gas6	gas6	NN
cord-283382-t890r7xp	243	25	)	)	-RRB-
cord-283382-t890r7xp	243	26	,	,	,
cord-283382-t890r7xp	243	27	can	can	MD
cord-283382-t890r7xp	243	28	bind	bind	VB
cord-283382-t890r7xp	243	29	differentially	differentially	RB
cord-283382-t890r7xp	243	30	to	to	IN
cord-283382-t890r7xp	243	31	the	the	DT
cord-283382-t890r7xp	243	32	fiber	fiber	NN
cord-283382-t890r7xp	243	33	of	of	IN
cord-283382-t890r7xp	243	34	rAd	rAd	NNP
cord-283382-t890r7xp	243	35	vectors	vector	NNS
cord-283382-t890r7xp	243	36	(	(	-LRB-
cord-283382-t890r7xp	243	37	151	151	CD
cord-283382-t890r7xp	243	38	)	)	-RRB-
cord-283382-t890r7xp	243	39	,	,	,
cord-283382-t890r7xp	243	40	interacting	interact	VBG
cord-283382-t890r7xp	243	41	with	with	IN
cord-283382-t890r7xp	243	42	a	a	DT
cord-283382-t890r7xp	243	43	putative	putative	JJ
cord-283382-t890r7xp	243	44	epitope	epitope	NN
cord-283382-t890r7xp	243	45	which	which	WDT
cord-283382-t890r7xp	243	46	is	be	VBZ
cord-283382-t890r7xp	243	47	outside	outside	RB
cord-283382-t890r7xp	243	48	of	of	IN
cord-283382-t890r7xp	243	49	the	the	DT
cord-283382-t890r7xp	243	50	fiber	fiber	NN
cord-283382-t890r7xp	243	51	knob	knob	NN
cord-283382-t890r7xp	243	52	domain	domain	NN
cord-283382-t890r7xp	243	53	,	,	,
cord-283382-t890r7xp	243	54	such	such	JJ
cord-283382-t890r7xp	243	55	as	as	IN
cord-283382-t890r7xp	243	56	the	the	DT
cord-283382-t890r7xp	243	57	fiber	fiber	NN
cord-283382-t890r7xp	243	58	shaft	shaft	NN
cord-283382-t890r7xp	243	59	.	.	.
cord-283382-t890r7xp	244	1	Interestingly	interestingly	RB
cord-283382-t890r7xp	244	2	,	,	,
cord-283382-t890r7xp	244	3	Gas6	Gas6	NNP
cord-283382-t890r7xp	244	4	bound	bind	VBD
cord-283382-t890r7xp	244	5	efficiently	efficiently	RB
cord-283382-t890r7xp	244	6	to	to	IN
cord-283382-t890r7xp	244	7	the	the	DT
cord-283382-t890r7xp	244	8	fiber	fiber	NN
cord-283382-t890r7xp	244	9	of	of	IN
cord-283382-t890r7xp	244	10	CAR	car	NN
cord-283382-t890r7xp	244	11	-	-	HYPH
cord-283382-t890r7xp	244	12	binding	bind	VBG
cord-283382-t890r7xp	244	13	Ad5	ad5	NN
cord-283382-t890r7xp	244	14	,	,	,
cord-283382-t890r7xp	244	15	without	without	IN
cord-283382-t890r7xp	244	16	affecting	affect	VBG
cord-283382-t890r7xp	244	17	its	-PRON-	PRP$
cord-283382-t890r7xp	244	18	ability	ability	NN
cord-283382-t890r7xp	244	19	to	to	TO
cord-283382-t890r7xp	244	20	enter	enter	VB
cord-283382-t890r7xp	244	21	cells	cell	NNS
cord-283382-t890r7xp	244	22	,	,	,
cord-283382-t890r7xp	244	23	but	but	CC
cord-283382-t890r7xp	244	24	significantly	significantly	RB
cord-283382-t890r7xp	244	25	reduced	reduce	VBD
cord-283382-t890r7xp	244	26	the	the	DT
cord-283382-t890r7xp	244	27	induction	induction	NN
cord-283382-t890r7xp	244	28	of	of	IN
cord-283382-t890r7xp	244	29	type	type	NN
cord-283382-t890r7xp	244	30	I	-PRON-	PRP
cord-283382-t890r7xp	244	31	IFNs	ifns	NN
cord-283382-t890r7xp	244	32	,	,	,
cord-283382-t890r7xp	244	33	resulting	result	VBG
cord-283382-t890r7xp	244	34	in	in	IN
cord-283382-t890r7xp	244	35	prolonged	prolong	VBN
cord-283382-t890r7xp	244	36	transgene	transgene	NN
cord-283382-t890r7xp	244	37	expression	expression	NN
cord-283382-t890r7xp	244	38	.	.	.
cord-283382-t890r7xp	245	1	Conversely	conversely	RB
cord-283382-t890r7xp	245	2	,	,	,
cord-283382-t890r7xp	245	3	Gas6	Gas6	NNP
cord-283382-t890r7xp	245	4	failed	fail	VBD
cord-283382-t890r7xp	245	5	to	to	TO
cord-283382-t890r7xp	245	6	bind	bind	VB
cord-283382-t890r7xp	245	7	to	to	IN
cord-283382-t890r7xp	245	8	the	the	DT
cord-283382-t890r7xp	245	9	fibers	fiber	NNS
cord-283382-t890r7xp	245	10	of	of	IN
cord-283382-t890r7xp	245	11	non	non	JJ
cord-283382-t890r7xp	245	12	-	-	JJ
cord-283382-t890r7xp	245	13	Ad5	ad5	JJ
cord-283382-t890r7xp	245	14	and	and	CC
cord-283382-t890r7xp	245	15	non	non	JJ
cord-283382-t890r7xp	245	16	-	-	JJ
cord-283382-t890r7xp	245	17	CAR	car	JJ
cord-283382-t890r7xp	245	18	binding	binding	NN
cord-283382-t890r7xp	245	19	viruses	virus	NNS
cord-283382-t890r7xp	245	20	,	,	,
cord-283382-t890r7xp	245	21	such	such	JJ
cord-283382-t890r7xp	245	22	as	as	IN
cord-283382-t890r7xp	245	23	a	a	DT
cord-283382-t890r7xp	245	24	species	species	NN
cord-283382-t890r7xp	245	25	D	D	NNP
cord-283382-t890r7xp	245	26	Ad	ad	NN
cord-283382-t890r7xp	245	27	vectors	vector	NNS
cord-283382-t890r7xp	245	28	HAdV	hadv	NN
cord-283382-t890r7xp	245	29	-	-	HYPH
cord-283382-t890r7xp	245	30	D28	D28	NNP
cord-283382-t890r7xp	245	31	,	,	,
cord-283382-t890r7xp	245	32	which	which	WDT
cord-283382-t890r7xp	245	33	has	have	VBZ
cord-283382-t890r7xp	245	34	been	be	VBN
cord-283382-t890r7xp	245	35	shown	show	VBN
cord-283382-t890r7xp	245	36	to	to	TO
cord-283382-t890r7xp	245	37	display	display	VB
cord-283382-t890r7xp	245	38	reduced	reduce	VBN
cord-283382-t890r7xp	245	39	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	245	40	in	in	IN
cord-283382-t890r7xp	245	41	mice	mouse	NNS
cord-283382-t890r7xp	245	42	when	when	WRB
cord-283382-t890r7xp	245	43	compared	compare	VBN
cord-283382-t890r7xp	245	44	with	with	IN
cord-283382-t890r7xp	245	45	rAd5	rAd5	NNS
cord-283382-t890r7xp	245	46	(	(	-LRB-
cord-283382-t890r7xp	245	47	152	152	CD
cord-283382-t890r7xp	245	48	)	)	-RRB-
cord-283382-t890r7xp	245	49	.	.	.
cord-283382-t890r7xp	246	1	In	in	IN
cord-283382-t890r7xp	246	2	support	support	NN
cord-283382-t890r7xp	246	3	of	of	IN
cord-283382-t890r7xp	246	4	this	this	DT
cord-283382-t890r7xp	246	5	,	,	,
cord-283382-t890r7xp	246	6	HAdV	HAdV	NNP
cord-283382-t890r7xp	246	7	-	-	HYPH
cord-283382-t890r7xp	246	8	D28	D28	NNP
cord-283382-t890r7xp	246	9	has	have	VBZ
cord-283382-t890r7xp	246	10	been	be	VBN
cord-283382-t890r7xp	246	11	shown	show	VBN
cord-283382-t890r7xp	246	12	to	to	TO
cord-283382-t890r7xp	246	13	elicit	elicit	VB
cord-283382-t890r7xp	246	14	robust	robust	JJ
cord-283382-t890r7xp	246	15	IFN	IFN	NNP
cord-283382-t890r7xp	246	16	-	-	HYPH
cord-283382-t890r7xp	246	17	α	α	NNP
cord-283382-t890r7xp	246	18	and	and	CC
cord-283382-t890r7xp	246	19	had	have	VBD
cord-283382-t890r7xp	246	20	increased	increase	VBN
cord-283382-t890r7xp	246	21	stimulation	stimulation	NN
cord-283382-t890r7xp	246	22	of	of	IN
cord-283382-t890r7xp	246	23	IFN	IFN	NNP
cord-283382-t890r7xp	246	24	-	-	HYPH
cord-283382-t890r7xp	246	25	responsive	responsive	JJ
cord-283382-t890r7xp	246	26	genes	gene	NNS
cord-283382-t890r7xp	246	27	when	when	WRB
cord-283382-t890r7xp	246	28	compared	compare	VBN
cord-283382-t890r7xp	246	29	with	with	IN
cord-283382-t890r7xp	246	30	Ad5	Ad5	NNP
cord-283382-t890r7xp	246	31	(	(	-LRB-
cord-283382-t890r7xp	246	32	44	44	CD
cord-283382-t890r7xp	246	33	)	)	-RRB-
cord-283382-t890r7xp	246	34	.	.	.
cord-283382-t890r7xp	247	1	Importantly	importantly	RB
cord-283382-t890r7xp	247	2	,	,	,
cord-283382-t890r7xp	247	3	immunization	immunization	NN
cord-283382-t890r7xp	247	4	of	of	IN
cord-283382-t890r7xp	247	5	IFNR1	ifnr1	NN
cord-283382-t890r7xp	247	6	−/−	−/−	NNP
cord-283382-t890r7xp	247	7	mice	mouse	NNS
cord-283382-t890r7xp	247	8	with	with	IN
cord-283382-t890r7xp	247	9	HAdV	HAdV	NNP
cord-283382-t890r7xp	247	10	-	-	HYPH
cord-283382-t890r7xp	247	11	D28	D28	NNP
cord-283382-t890r7xp	247	12	resulted	result	VBD
cord-283382-t890r7xp	247	13	in	in	IN
cord-283382-t890r7xp	247	14	robust	robust	JJ
cord-283382-t890r7xp	247	15	cellular	cellular	JJ
cord-283382-t890r7xp	247	16	immune	immune	JJ
cord-283382-t890r7xp	247	17	responses	response	NNS
cord-283382-t890r7xp	247	18	,	,	,
cord-283382-t890r7xp	247	19	comparable	comparable	JJ
cord-283382-t890r7xp	247	20	to	to	IN
cord-283382-t890r7xp	247	21	Ad5	Ad5	NNP
cord-283382-t890r7xp	247	22	(	(	-LRB-
cord-283382-t890r7xp	247	23	44	44	CD
cord-283382-t890r7xp	247	24	)	)	-RRB-
cord-283382-t890r7xp	247	25	.	.	.
cord-283382-t890r7xp	248	1	These	these	DT
cord-283382-t890r7xp	248	2	data	datum	NNS
cord-283382-t890r7xp	248	3	support	support	VBP
cord-283382-t890r7xp	248	4	the	the	DT
cord-283382-t890r7xp	248	5	hypothesis	hypothesis	NN
cord-283382-t890r7xp	248	6	by	by	IN
cord-283382-t890r7xp	248	7	several	several	JJ
cord-283382-t890r7xp	248	8	other	other	JJ
cord-283382-t890r7xp	248	9	groups	group	NNS
cord-283382-t890r7xp	248	10	that	that	IN
cord-283382-t890r7xp	248	11	Ad	ad	NN
cord-283382-t890r7xp	248	12	vectors	vector	NNS
cord-283382-t890r7xp	248	13	which	which	WDT
cord-283382-t890r7xp	248	14	trigger	trigger	VBP
cord-283382-t890r7xp	248	15	robust	robust	JJ
cord-283382-t890r7xp	248	16	type	type	NN
cord-283382-t890r7xp	249	1	I	-PRON-	PRP
cord-283382-t890r7xp	249	2	IFN	IFN	NNP
cord-283382-t890r7xp	249	3	responses	response	NNS
cord-283382-t890r7xp	249	4	exhibit	exhibit	VBP
cord-283382-t890r7xp	249	5	reduced	reduce	VBN
cord-283382-t890r7xp	249	6	transgene	transgene	NN
cord-283382-t890r7xp	249	7	expression	expression	NN
cord-283382-t890r7xp	249	8	and	and	CC
cord-283382-t890r7xp	249	9	impaired	impaired	JJ
cord-283382-t890r7xp	249	10	vaccine	vaccine	NN
cord-283382-t890r7xp	249	11	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	249	12	(	(	-LRB-
cord-283382-t890r7xp	249	13	33	33	CD
cord-283382-t890r7xp	249	14	,	,	,
cord-283382-t890r7xp	249	15	120	120	CD
cord-283382-t890r7xp	249	16	)	)	-RRB-
cord-283382-t890r7xp	249	17	.	.	.
cord-283382-t890r7xp	250	1	Therefore	therefore	RB
cord-283382-t890r7xp	250	2	,	,	,
cord-283382-t890r7xp	250	3	one	one	CD
cord-283382-t890r7xp	250	4	strategy	strategy	NN
cord-283382-t890r7xp	250	5	to	to	TO
cord-283382-t890r7xp	250	6	overcome	overcome	VB
cord-283382-t890r7xp	250	7	stimulation	stimulation	NN
cord-283382-t890r7xp	250	8	of	of	IN
cord-283382-t890r7xp	250	9	IFN	IFN	NNP
cord-283382-t890r7xp	250	10	-	-	HYPH
cord-283382-t890r7xp	250	11	α	α	NNP
cord-283382-t890r7xp	250	12	could	could	MD
cord-283382-t890r7xp	250	13	be	be	VB
cord-283382-t890r7xp	250	14	to	to	TO
cord-283382-t890r7xp	250	15	identify	identify	VB
cord-283382-t890r7xp	250	16	the	the	DT
cord-283382-t890r7xp	250	17	precise	precise	JJ
cord-283382-t890r7xp	250	18	amino	amino	NN
cord-283382-t890r7xp	250	19	acid	acid	NN
cord-283382-t890r7xp	250	20	binding	bind	VBG
cord-283382-t890r7xp	250	21	epitopes	epitope	NNS
cord-283382-t890r7xp	250	22	for	for	IN
cord-283382-t890r7xp	250	23	Gas6	Gas6	NNP
cord-283382-t890r7xp	250	24	and	and	CC
cord-283382-t890r7xp	250	25	genetically	genetically	RB
cord-283382-t890r7xp	250	26	engineer	engineer	VBP
cord-283382-t890r7xp	250	27	this	this	DT
cord-283382-t890r7xp	250	28	region	region	NN
cord-283382-t890r7xp	250	29	into	into	IN
cord-283382-t890r7xp	250	30	the	the	DT
cord-283382-t890r7xp	250	31	fiber	fiber	NN
cord-283382-t890r7xp	250	32	of	of	IN
cord-283382-t890r7xp	250	33	non	non	JJ
cord-283382-t890r7xp	250	34	-	-	JJ
cord-283382-t890r7xp	250	35	Gas6	gas6	JJ
cord-283382-t890r7xp	250	36	binding	bind	VBG
cord-283382-t890r7xp	250	37	Ad	ad	NN
cord-283382-t890r7xp	250	38	vectors	vector	NNS
cord-283382-t890r7xp	250	39	in	in	IN
cord-283382-t890r7xp	250	40	an	an	DT
cord-283382-t890r7xp	250	41	effort	effort	NN
cord-283382-t890r7xp	250	42	to	to	TO
cord-283382-t890r7xp	250	43	increase	increase	VB
cord-283382-t890r7xp	250	44	their	-PRON-	PRP$
cord-283382-t890r7xp	250	45	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	250	46	(	(	-LRB-
cord-283382-t890r7xp	250	47	151	151	CD
cord-283382-t890r7xp	250	48	)	)	-RRB-
cord-283382-t890r7xp	250	49	.	.	.
cord-283382-t890r7xp	251	1	In	in	IN
cord-283382-t890r7xp	251	2	addition	addition	NN
cord-283382-t890r7xp	251	3	to	to	IN
cord-283382-t890r7xp	251	4	interactions	interaction	NNS
cord-283382-t890r7xp	251	5	with	with	IN
cord-283382-t890r7xp	251	6	CAR	car	NN
cord-283382-t890r7xp	251	7	,	,	,
cord-283382-t890r7xp	251	8	interactions	interaction	NNS
cord-283382-t890r7xp	251	9	between	between	IN
cord-283382-t890r7xp	251	10	the	the	DT
cord-283382-t890r7xp	251	11	RGD	RGD	NNP
cord-283382-t890r7xp	251	12	motif	motif	NN
cord-283382-t890r7xp	251	13	within	within	IN
cord-283382-t890r7xp	251	14	the	the	DT
cord-283382-t890r7xp	251	15	penton	penton	NNP
cord-283382-t890r7xp	251	16	base	base	NN
cord-283382-t890r7xp	251	17	and	and	CC
cord-283382-t890r7xp	251	18	cellular	cellular	JJ
cord-283382-t890r7xp	251	19	integrins	integrin	NNS
cord-283382-t890r7xp	251	20	can	can	MD
cord-283382-t890r7xp	251	21	contribute	contribute	VB
cord-283382-t890r7xp	251	22	to	to	IN
cord-283382-t890r7xp	251	23	the	the	DT
cord-283382-t890r7xp	251	24	induction	induction	NN
cord-283382-t890r7xp	251	25	of	of	IN
cord-283382-t890r7xp	251	26	innate	innate	JJ
cord-283382-t890r7xp	251	27	immune	immune	JJ
cord-283382-t890r7xp	251	28	signaling	signal	VBG
cord-283382-t890r7xp	251	29	pathways	pathway	NNS
cord-283382-t890r7xp	252	1	both	both	DT
cord-283382-t890r7xp	252	2	in	in	IN
cord-283382-t890r7xp	252	3	vitro	vitro	FW
cord-283382-t890r7xp	252	4	(	(	-LRB-
cord-283382-t890r7xp	252	5	153	153	CD
cord-283382-t890r7xp	252	6	)	)	-RRB-
cord-283382-t890r7xp	252	7	and	and	CC
cord-283382-t890r7xp	252	8	in	in	IN
cord-283382-t890r7xp	252	9	vivo	vivo	NNP
cord-283382-t890r7xp	252	10	(	(	-LRB-
cord-283382-t890r7xp	252	11	77	77	CD
cord-283382-t890r7xp	252	12	)	)	-RRB-
cord-283382-t890r7xp	252	13	.	.	.
cord-283382-t890r7xp	253	1	Following	follow	VBG
cord-283382-t890r7xp	253	2	i.v	i.v	NNP
cord-283382-t890r7xp	253	3	.	.	NNP
cord-283382-t890r7xp	253	4	administration	administration	NN
cord-283382-t890r7xp	253	5	of	of	IN
cord-283382-t890r7xp	253	6	Ad5	Ad5	NNP
cord-283382-t890r7xp	253	7	,	,	,
cord-283382-t890r7xp	253	8	interactions	interaction	NNS
cord-283382-t890r7xp	253	9	between	between	IN
cord-283382-t890r7xp	253	10	the	the	DT
cord-283382-t890r7xp	253	11	β3	β3	NNP
cord-283382-t890r7xp	253	12	subunit	subunit	NN
cord-283382-t890r7xp	253	13	of	of	IN
cord-283382-t890r7xp	253	14	cellular	cellular	JJ
cord-283382-t890r7xp	253	15	integrins	integrin	NNS
cord-283382-t890r7xp	253	16	and	and	CC
cord-283382-t890r7xp	253	17	the	the	DT
cord-283382-t890r7xp	253	18	RGD	RGD	NNP
cord-283382-t890r7xp	253	19	motif	motif	NN
cord-283382-t890r7xp	253	20	on	on	IN
cord-283382-t890r7xp	253	21	MARCO	MARCO	NNP
cord-283382-t890r7xp	253	22	+	+	CC
cord-283382-t890r7xp	253	23	marginal	marginal	JJ
cord-283382-t890r7xp	253	24	zone	zone	NN
cord-283382-t890r7xp	253	25	macrophages	macrophage	NNS
cord-283382-t890r7xp	253	26	in	in	IN
cord-283382-t890r7xp	253	27	the	the	DT
cord-283382-t890r7xp	253	28	spleen	spleen	NNS
cord-283382-t890r7xp	253	29	were	be	VBD
cord-283382-t890r7xp	253	30	required	require	VBN
cord-283382-t890r7xp	253	31	for	for	IN
cord-283382-t890r7xp	253	32	triggering	trigger	VBG
cord-283382-t890r7xp	253	33	IL-1α	il-1α	NN
cord-283382-t890r7xp	253	34	-	-	HYPH
cord-283382-t890r7xp	253	35	dependent	dependent	JJ
cord-283382-t890r7xp	253	36	innate	innate	JJ
cord-283382-t890r7xp	253	37	immune	immune	JJ
cord-283382-t890r7xp	253	38	signaling	signaling	NN
cord-283382-t890r7xp	253	39	in	in	IN
cord-283382-t890r7xp	253	40	mice	mouse	NNS
cord-283382-t890r7xp	253	41	(	(	-LRB-
cord-283382-t890r7xp	253	42	77	77	CD
cord-283382-t890r7xp	253	43	)	)	-RRB-
cord-283382-t890r7xp	253	44	.	.	.
cord-283382-t890r7xp	254	1	However	however	RB
cord-283382-t890r7xp	254	2	,	,	,
cord-283382-t890r7xp	254	3	it	-PRON-	PRP
cord-283382-t890r7xp	254	4	is	be	VBZ
cord-283382-t890r7xp	254	5	unclear	unclear	JJ
cord-283382-t890r7xp	254	6	how	how	WRB
cord-283382-t890r7xp	254	7	these	these	DT
cord-283382-t890r7xp	254	8	interactions	interaction	NNS
cord-283382-t890r7xp	254	9	affect	affect	VBP
cord-283382-t890r7xp	254	10	immune	immune	JJ
cord-283382-t890r7xp	254	11	responses	response	NNS
cord-283382-t890r7xp	254	12	following	follow	VBG
cord-283382-t890r7xp	254	13	immunization	immunization	NN
cord-283382-t890r7xp	254	14	by	by	IN
cord-283382-t890r7xp	254	15	other	other	JJ
cord-283382-t890r7xp	254	16	routes	route	NNS
cord-283382-t890r7xp	254	17	of	of	IN
cord-283382-t890r7xp	254	18	administration	administration	NN
cord-283382-t890r7xp	254	19	.	.	.
cord-283382-t890r7xp	255	1	Finally	finally	RB
cord-283382-t890r7xp	255	2	,	,	,
cord-283382-t890r7xp	255	3	the	the	DT
cord-283382-t890r7xp	255	4	Ad	ad	NN
cord-283382-t890r7xp	255	5	virion	virion	NN
cord-283382-t890r7xp	255	6	itself	-PRON-	PRP
cord-283382-t890r7xp	255	7	and	and	CC
cord-283382-t890r7xp	255	8	its	-PRON-	PRP$
cord-283382-t890r7xp	255	9	major	major	JJ
cord-283382-t890r7xp	255	10	capsid	capsid	NN
cord-283382-t890r7xp	255	11	protein	protein	NN
cord-283382-t890r7xp	255	12	,	,	,
cord-283382-t890r7xp	255	13	the	the	DT
cord-283382-t890r7xp	255	14	hexon	hexon	NN
cord-283382-t890r7xp	255	15	,	,	,
cord-283382-t890r7xp	255	16	has	have	VBZ
cord-283382-t890r7xp	255	17	been	be	VBN
cord-283382-t890r7xp	255	18	described	describe	VBN
cord-283382-t890r7xp	255	19	as	as	IN
cord-283382-t890r7xp	255	20	a	a	DT
cord-283382-t890r7xp	255	21	potent	potent	JJ
cord-283382-t890r7xp	255	22	adjuvant	adjuvant	NN
cord-283382-t890r7xp	255	23	,	,	,
cord-283382-t890r7xp	255	24	capable	capable	JJ
cord-283382-t890r7xp	255	25	of	of	IN
cord-283382-t890r7xp	255	26	activating	activate	VBG
cord-283382-t890r7xp	255	27	CD4	CD4	NNP
cord-283382-t890r7xp	255	28	+	+	CC
cord-283382-t890r7xp	255	29	and	and	CC
cord-283382-t890r7xp	255	30	CD8	CD8	NNP
cord-283382-t890r7xp	255	31	+	+	CC
cord-283382-t890r7xp	255	32	cellular	cellular	JJ
cord-283382-t890r7xp	255	33	immune	immune	JJ
cord-283382-t890r7xp	255	34	responses	response	NNS
cord-283382-t890r7xp	255	35	to	to	IN
cord-283382-t890r7xp	255	36	a	a	DT
cord-283382-t890r7xp	255	37	model	model	NN
cord-283382-t890r7xp	255	38	immunogen	immunogen	NN
cord-283382-t890r7xp	255	39	mixture	mixture	NN
cord-283382-t890r7xp	255	40	in	in	IN
cord-283382-t890r7xp	255	41	mice	mouse	NNS
cord-283382-t890r7xp	255	42	(	(	-LRB-
cord-283382-t890r7xp	255	43	146	146	CD
cord-283382-t890r7xp	255	44	)	)	-RRB-
cord-283382-t890r7xp	255	45	.	.	.
cord-283382-t890r7xp	256	1	Although	although	IN
cord-283382-t890r7xp	256	2	the	the	DT
cord-283382-t890r7xp	256	3	precise	precise	JJ
cord-283382-t890r7xp	256	4	mechanism	mechanism	NN
cord-283382-t890r7xp	256	5	underlying	underlie	VBG
cord-283382-t890r7xp	256	6	this	this	DT
cord-283382-t890r7xp	256	7	effect	effect	NN
cord-283382-t890r7xp	256	8	has	have	VBZ
cord-283382-t890r7xp	256	9	not	not	RB
cord-283382-t890r7xp	256	10	been	be	VBN
cord-283382-t890r7xp	256	11	identified	identify	VBN
cord-283382-t890r7xp	256	12	,	,	,
cord-283382-t890r7xp	256	13	subsequent	subsequent	JJ
cord-283382-t890r7xp	256	14	studies	study	NNS
cord-283382-t890r7xp	256	15	have	have	VBP
cord-283382-t890r7xp	256	16	suggested	suggest	VBN
cord-283382-t890r7xp	256	17	that	that	IN
cord-283382-t890r7xp	256	18	the	the	DT
cord-283382-t890r7xp	256	19	HVR	HVR	NNP
cord-283382-t890r7xp	256	20	regions	region	NNS
cord-283382-t890r7xp	256	21	,	,	,
cord-283382-t890r7xp	256	22	particularly	particularly	RB
cord-283382-t890r7xp	256	23	HVR1	HVR1	NNP
cord-283382-t890r7xp	256	24	,	,	,
cord-283382-t890r7xp	256	25	are	be	VBP
cord-283382-t890r7xp	256	26	involved	involve	VBN
cord-283382-t890r7xp	256	27	in	in	IN
cord-283382-t890r7xp	256	28	enhancing	enhance	VBG
cord-283382-t890r7xp	256	29	interactions	interaction	NNS
cord-283382-t890r7xp	256	30	with	with	IN
cord-283382-t890r7xp	256	31	scavenging	scavenging	NN
cord-283382-t890r7xp	256	32	macrophages	macrophage	NNS
cord-283382-t890r7xp	256	33	(	(	-LRB-
cord-283382-t890r7xp	256	34	76	76	CD
cord-283382-t890r7xp	256	35	,	,	,
cord-283382-t890r7xp	256	36	78	78	CD
cord-283382-t890r7xp	256	37	)	)	-RRB-
cord-283382-t890r7xp	256	38	.	.	.
cord-283382-t890r7xp	257	1	One	one	CD
cord-283382-t890r7xp	257	2	approach	approach	NN
cord-283382-t890r7xp	257	3	to	to	IN
cord-283382-t890r7xp	257	4	identifying	identify	VBG
cord-283382-t890r7xp	257	5	lead	lead	JJ
cord-283382-t890r7xp	257	6	vaccine	vaccine	NN
cord-283382-t890r7xp	257	7	candidates	candidate	NNS
cord-283382-t890r7xp	257	8	is	be	VBZ
cord-283382-t890r7xp	257	9	to	to	TO
cord-283382-t890r7xp	257	10	perform	perform	VB
cord-283382-t890r7xp	257	11	head	head	NN
cord-283382-t890r7xp	257	12	-	-	HYPH
cord-283382-t890r7xp	257	13	to	to	IN
cord-283382-t890r7xp	257	14	-	-	HYPH
cord-283382-t890r7xp	257	15	head	head	NN
cord-283382-t890r7xp	257	16	comparisons	comparison	NNS
cord-283382-t890r7xp	257	17	of	of	IN
cord-283382-t890r7xp	257	18	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	257	19	in	in	IN
cord-283382-t890r7xp	257	20	animal	animal	NN
cord-283382-t890r7xp	257	21	models	model	NNS
cord-283382-t890r7xp	257	22	to	to	TO
cord-283382-t890r7xp	257	23	identify	identify	VB
cord-283382-t890r7xp	257	24	the	the	DT
cord-283382-t890r7xp	257	25	most	most	RBS
cord-283382-t890r7xp	257	26	immunogenic	immunogenic	JJ
cord-283382-t890r7xp	257	27	vectors	vector	NNS
cord-283382-t890r7xp	257	28	,	,	,
cord-283382-t890r7xp	257	29	followed	follow	VBN
cord-283382-t890r7xp	257	30	by	by	IN
cord-283382-t890r7xp	257	31	detailed	detailed	JJ
cord-283382-t890r7xp	257	32	and	and	CC
cord-283382-t890r7xp	257	33	systematic	systematic	JJ
cord-283382-t890r7xp	257	34	experimental	experimental	JJ
cord-283382-t890r7xp	257	35	studies	study	NNS
cord-283382-t890r7xp	257	36	to	to	TO
cord-283382-t890r7xp	257	37	try	try	VB
cord-283382-t890r7xp	257	38	to	to	TO
cord-283382-t890r7xp	257	39	identify	identify	VB
cord-283382-t890r7xp	257	40	the	the	DT
cord-283382-t890r7xp	257	41	underlying	underlie	VBG
cord-283382-t890r7xp	257	42	mechanisms	mechanism	NNS
cord-283382-t890r7xp	257	43	which	which	WDT
cord-283382-t890r7xp	257	44	contribute	contribute	VBP
cord-283382-t890r7xp	257	45	to	to	IN
cord-283382-t890r7xp	257	46	immunological	immunological	JJ
cord-283382-t890r7xp	257	47	potency	potency	NN
cord-283382-t890r7xp	257	48	(	(	-LRB-
cord-283382-t890r7xp	257	49	i.e.	i.e.	FW
cord-283382-t890r7xp	257	50	,	,	,
cord-283382-t890r7xp	257	51	transgene	transgene	JJ
cord-283382-t890r7xp	257	52	expression	expression	NN
cord-283382-t890r7xp	257	53	magnitude	magnitude	NN
cord-283382-t890r7xp	257	54	and	and	CC
cord-283382-t890r7xp	257	55	duration	duration	NN
cord-283382-t890r7xp	257	56	,	,	,
cord-283382-t890r7xp	257	57	innate	innate	JJ
cord-283382-t890r7xp	257	58	immune	immune	JJ
cord-283382-t890r7xp	257	59	stimulation	stimulation	NN
cord-283382-t890r7xp	257	60	)	)	-RRB-
cord-283382-t890r7xp	257	61	.	.	.
cord-283382-t890r7xp	258	1	However	however	RB
cord-283382-t890r7xp	258	2	,	,	,
cord-283382-t890r7xp	258	3	in	in	IN
cord-283382-t890r7xp	258	4	the	the	DT
cord-283382-t890r7xp	258	5	interim	interim	NN
cord-283382-t890r7xp	258	6	,	,	,
cord-283382-t890r7xp	258	7	efforts	effort	NNS
cord-283382-t890r7xp	258	8	are	be	VBP
cord-283382-t890r7xp	258	9	ongoing	ongoing	JJ
cord-283382-t890r7xp	258	10	to	to	TO
cord-283382-t890r7xp	258	11	try	try	VB
cord-283382-t890r7xp	258	12	to	to	TO
cord-283382-t890r7xp	258	13	maximize	maximize	VB
cord-283382-t890r7xp	258	14	immune	immune	JJ
cord-283382-t890r7xp	258	15	recognition	recognition	NN
cord-283382-t890r7xp	258	16	of	of	IN
cord-283382-t890r7xp	258	17	the	the	DT
cord-283382-t890r7xp	258	18	Ad	Ad	NNP
cord-283382-t890r7xp	258	19	encoded	encode	VBN
cord-283382-t890r7xp	258	20	Ag	Ag	NNP
cord-283382-t890r7xp	258	21	,	,	,
cord-283382-t890r7xp	258	22	in	in	IN
cord-283382-t890r7xp	258	23	an	an	DT
cord-283382-t890r7xp	258	24	effort	effort	NN
cord-283382-t890r7xp	258	25	to	to	TO
cord-283382-t890r7xp	258	26	compensate	compensate	VB
cord-283382-t890r7xp	258	27	for	for	IN
cord-283382-t890r7xp	258	28	the	the	DT
cord-283382-t890r7xp	258	29	reduced	reduce	VBN
cord-283382-t890r7xp	258	30	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	258	31	associated	associate	VBN
cord-283382-t890r7xp	258	32	with	with	IN
cord-283382-t890r7xp	258	33	certain	certain	JJ
cord-283382-t890r7xp	258	34	Ad	ad	NN
cord-283382-t890r7xp	258	35	vectors	vector	NNS
cord-283382-t890r7xp	258	36	which	which	WDT
cord-283382-t890r7xp	258	37	are	be	VBP
cord-283382-t890r7xp	258	38	otherwise	otherwise	RB
cord-283382-t890r7xp	258	39	an	an	DT
cord-283382-t890r7xp	258	40	ideal	ideal	JJ
cord-283382-t890r7xp	258	41	platform	platform	NN
cord-283382-t890r7xp	258	42	(	(	-LRB-
cord-283382-t890r7xp	258	43	i.e.	i.e.	FW
cord-283382-t890r7xp	258	44	,	,	,
cord-283382-t890r7xp	258	45	low	low	JJ
cord-283382-t890r7xp	258	46	seroprevalence	seroprevalence	NN
cord-283382-t890r7xp	258	47	,	,	,
cord-283382-t890r7xp	258	48	high	high	JJ
cord-283382-t890r7xp	258	49	titer	titer	NN
cord-283382-t890r7xp	258	50	growth	growth	NN
cord-283382-t890r7xp	258	51	,	,	,
cord-283382-t890r7xp	258	52	stability	stability	NN
cord-283382-t890r7xp	258	53	)	)	-RRB-
cord-283382-t890r7xp	258	54	.	.	.
cord-283382-t890r7xp	259	1	Furthermore	furthermore	RB
cord-283382-t890r7xp	259	2	,	,	,
cord-283382-t890r7xp	259	3	this	this	DT
cord-283382-t890r7xp	259	4	type	type	NN
cord-283382-t890r7xp	259	5	of	of	IN
cord-283382-t890r7xp	259	6	modification	modification	NN
cord-283382-t890r7xp	259	7	could	could	MD
cord-283382-t890r7xp	259	8	permit	permit	VB
cord-283382-t890r7xp	259	9	dose	dose	NN
cord-283382-t890r7xp	259	10	-	-	HYPH
cord-283382-t890r7xp	259	11	sparing	sparing	NN
cord-283382-t890r7xp	259	12	,	,	,
cord-283382-t890r7xp	259	13	which	which	WDT
cord-283382-t890r7xp	259	14	would	would	MD
cord-283382-t890r7xp	259	15	have	have	VB
cord-283382-t890r7xp	259	16	cost	cost	NN
cord-283382-t890r7xp	259	17	saving	saving	NN
cord-283382-t890r7xp	259	18	effects	effect	NNS
cord-283382-t890r7xp	259	19	,	,	,
cord-283382-t890r7xp	259	20	as	as	RB
cord-283382-t890r7xp	259	21	well	well	RB
cord-283382-t890r7xp	259	22	as	as	IN
cord-283382-t890r7xp	259	23	minimizing	minimize	VBG
cord-283382-t890r7xp	259	24	any	any	DT
cord-283382-t890r7xp	259	25	vector	vector	NN
cord-283382-t890r7xp	259	26	-	-	HYPH
cord-283382-t890r7xp	259	27	induced	induce	VBN
cord-283382-t890r7xp	259	28	reactogenicity	reactogenicity	NN
cord-283382-t890r7xp	259	29	,	,	,
cord-283382-t890r7xp	259	30	without	without	IN
cord-283382-t890r7xp	259	31	compromising	compromise	VBG
cord-283382-t890r7xp	259	32	on	on	IN
cord-283382-t890r7xp	259	33	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	259	34	.	.	.
cord-283382-t890r7xp	260	1	Such	such	JJ
cord-283382-t890r7xp	260	2	approaches	approach	NNS
cord-283382-t890r7xp	260	3	include	include	VBP
cord-283382-t890r7xp	260	4	the	the	DT
cord-283382-t890r7xp	260	5	use	use	NN
cord-283382-t890r7xp	260	6	of	of	IN
cord-283382-t890r7xp	260	7	molecular	molecular	JJ
cord-283382-t890r7xp	260	8	or	or	CC
cord-283382-t890r7xp	260	9	genetic	genetic	JJ
cord-283382-t890r7xp	260	10	adjuvants	adjuvant	NNS
cord-283382-t890r7xp	260	11	,	,	,
cord-283382-t890r7xp	260	12	namely	namely	RB
cord-283382-t890r7xp	260	13	in	in	IN
cord-283382-t890r7xp	260	14	the	the	DT
cord-283382-t890r7xp	260	15	form	form	NN
cord-283382-t890r7xp	260	16	of	of	IN
cord-283382-t890r7xp	260	17	fusion	fusion	NN
cord-283382-t890r7xp	260	18	proteins	protein	NNS
cord-283382-t890r7xp	260	19	with	with	IN
cord-283382-t890r7xp	260	20	the	the	DT
cord-283382-t890r7xp	260	21	vaccine	vaccine	NN
cord-283382-t890r7xp	260	22	antigen	antigen	NN
cord-283382-t890r7xp	260	23	of	of	IN
cord-283382-t890r7xp	260	24	interest	interest	NN
cord-283382-t890r7xp	260	25	,	,	,
cord-283382-t890r7xp	260	26	which	which	WDT
cord-283382-t890r7xp	260	27	help	help	VBP
cord-283382-t890r7xp	260	28	to	to	TO
cord-283382-t890r7xp	260	29	potentiate	potentiate	VB
cord-283382-t890r7xp	260	30	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	260	31	by	by	IN
cord-283382-t890r7xp	260	32	enhancing	enhance	VBG
cord-283382-t890r7xp	260	33	Ag	Ag	NNP
cord-283382-t890r7xp	260	34	presentation	presentation	NN
cord-283382-t890r7xp	260	35	or	or	CC
cord-283382-t890r7xp	260	36	dissemination	dissemination	NN
cord-283382-t890r7xp	260	37	[	[	-LRB-
cord-283382-t890r7xp	260	38	reviewed	review	VBN
cord-283382-t890r7xp	260	39	in	in	IN
cord-283382-t890r7xp	260	40	detail	detail	NN
cord-283382-t890r7xp	260	41	by	by	IN
cord-283382-t890r7xp	260	42	Neukirch	Neukirch	NNP
cord-283382-t890r7xp	260	43	et	et	NNP
cord-283382-t890r7xp	260	44	al	al	NNP
cord-283382-t890r7xp	260	45	.	.	.
cord-283382-t890r7xp	261	1	(	(	-LRB-
cord-283382-t890r7xp	261	2	154	154	CD
cord-283382-t890r7xp	261	3	)	)	-RRB-
cord-283382-t890r7xp	261	4	]	]	-RRB-
cord-283382-t890r7xp	261	5	.	.	.
cord-283382-t890r7xp	262	1	One	one	CD
cord-283382-t890r7xp	262	2	such	such	JJ
cord-283382-t890r7xp	262	3	approach	approach	NN
cord-283382-t890r7xp	262	4	which	which	WDT
cord-283382-t890r7xp	262	5	has	have	VBZ
cord-283382-t890r7xp	262	6	previously	previously	RB
cord-283382-t890r7xp	262	7	been	be	VBN
cord-283382-t890r7xp	262	8	described	describe	VBN
cord-283382-t890r7xp	262	9	includes	include	VBZ
cord-283382-t890r7xp	262	10	the	the	DT
cord-283382-t890r7xp	262	11	generation	generation	NN
cord-283382-t890r7xp	262	12	of	of	IN
cord-283382-t890r7xp	262	13	fusion	fusion	NN
cord-283382-t890r7xp	262	14	-	-	:
cord-283382-t890r7xp	262	15	Ag	Ag	NNP
cord-283382-t890r7xp	262	16	cassettes	cassette	NNS
cord-283382-t890r7xp	262	17	which	which	WDT
cord-283382-t890r7xp	262	18	enhance	enhance	VBP
cord-283382-t890r7xp	262	19	MHC	MHC	NNP
cord-283382-t890r7xp	262	20	presentation	presentation	NN
cord-283382-t890r7xp	262	21	.	.	.
cord-283382-t890r7xp	263	1	This	this	DT
cord-283382-t890r7xp	263	2	can	can	MD
cord-283382-t890r7xp	263	3	be	be	VB
cord-283382-t890r7xp	263	4	achieved	achieve	VBN
cord-283382-t890r7xp	263	5	by	by	IN
cord-283382-t890r7xp	263	6	fusing	fuse	VBG
cord-283382-t890r7xp	263	7	vaccine	vaccine	NN
cord-283382-t890r7xp	263	8	Ag	Ag	NNP
cord-283382-t890r7xp	263	9	to	to	IN
cord-283382-t890r7xp	263	10	β	β	NN
cord-283382-t890r7xp	263	11	-	-	HYPH
cord-283382-t890r7xp	263	12	microglobulin	microglobulin	NN
cord-283382-t890r7xp	263	13	for	for	IN
cord-283382-t890r7xp	263	14	enhanced	enhance	VBN
cord-283382-t890r7xp	263	15	MHC	MHC	NNP
cord-283382-t890r7xp	263	16	I	i	CD
cord-283382-t890r7xp	263	17	presentation	presentation	NN
cord-283382-t890r7xp	263	18	(	(	-LRB-
cord-283382-t890r7xp	263	19	155	155	CD
cord-283382-t890r7xp	263	20	)	)	-RRB-
cord-283382-t890r7xp	263	21	,	,	,
cord-283382-t890r7xp	263	22	or	or	CC
cord-283382-t890r7xp	263	23	to	to	IN
cord-283382-t890r7xp	263	24	the	the	DT
cord-283382-t890r7xp	263	25	invariant	invariant	JJ
cord-283382-t890r7xp	263	26	chain	chain	NN
cord-283382-t890r7xp	263	27	of	of	IN
cord-283382-t890r7xp	263	28	MHC	MHC	NNP
cord-283382-t890r7xp	263	29	II	II	NNP
cord-283382-t890r7xp	263	30	(	(	-LRB-
cord-283382-t890r7xp	263	31	156	156	CD
cord-283382-t890r7xp	263	32	)	)	-RRB-
cord-283382-t890r7xp	263	33	(	(	-LRB-
cord-283382-t890r7xp	263	34	157	157	CD
cord-283382-t890r7xp	263	35	)	)	-RRB-
cord-283382-t890r7xp	263	36	(	(	-LRB-
cord-283382-t890r7xp	263	37	158	158	CD
cord-283382-t890r7xp	263	38	)	)	-RRB-
cord-283382-t890r7xp	263	39	(	(	-LRB-
cord-283382-t890r7xp	263	40	159	159	CD
cord-283382-t890r7xp	263	41	)	)	-RRB-
cord-283382-t890r7xp	263	42	.	.	.
cord-283382-t890r7xp	264	1	These	these	DT
cord-283382-t890r7xp	264	2	approaches	approach	NNS
cord-283382-t890r7xp	264	3	were	be	VBD
cord-283382-t890r7xp	264	4	capable	capable	JJ
cord-283382-t890r7xp	264	5	of	of	IN
cord-283382-t890r7xp	264	6	enhancing	enhance	VBG
cord-283382-t890r7xp	264	7	antigen	antigen	NN
cord-283382-t890r7xp	264	8	-	-	HYPH
cord-283382-t890r7xp	264	9	specific	specific	JJ
cord-283382-t890r7xp	264	10	CD8	CD8	NNP
cord-283382-t890r7xp	264	11	+	+	CC
cord-283382-t890r7xp	264	12	T	T	NNP
cord-283382-t890r7xp	264	13	cells	cell	NNS
cord-283382-t890r7xp	264	14	responses	response	NNS
cord-283382-t890r7xp	264	15	in	in	IN
cord-283382-t890r7xp	264	16	mice	mice	NN
cord-283382-t890r7xp	264	17	following	follow	VBG
cord-283382-t890r7xp	264	18	immunization	immunization	NN
cord-283382-t890r7xp	264	19	with	with	IN
cord-283382-t890r7xp	264	20	an	an	DT
cord-283382-t890r7xp	264	21	Ad	ad	NN
cord-283382-t890r7xp	264	22	vector	vector	NN
cord-283382-t890r7xp	264	23	encoding	encode	VBG
cord-283382-t890r7xp	264	24	the	the	DT
cord-283382-t890r7xp	264	25	Ii	Ii	NNP
cord-283382-t890r7xp	264	26	or	or	CC
cord-283382-t890r7xp	264	27	β2-microglobulin	β2-microglobulin	NNP
cord-283382-t890r7xp	264	28	fusion	fusion	NN
cord-283382-t890r7xp	264	29	antigen	antigen	NN
cord-283382-t890r7xp	264	30	.	.	.
cord-283382-t890r7xp	265	1	In	in	IN
cord-283382-t890r7xp	265	2	a	a	DT
cord-283382-t890r7xp	265	3	separate	separate	JJ
cord-283382-t890r7xp	265	4	approach	approach	NN
cord-283382-t890r7xp	265	5	,	,	,
cord-283382-t890r7xp	265	6	we	-PRON-	PRP
cord-283382-t890r7xp	265	7	recently	recently	RB
cord-283382-t890r7xp	265	8	have	have	VBP
cord-283382-t890r7xp	265	9	shown	show	VBN
cord-283382-t890r7xp	265	10	that	that	IN
cord-283382-t890r7xp	265	11	encoding	encode	VBG
cord-283382-t890r7xp	265	12	vaccine	vaccine	NN
cord-283382-t890r7xp	265	13	Ag	Ag	NNP
cord-283382-t890r7xp	265	14	cassettes	cassette	NNS
cord-283382-t890r7xp	265	15	in	in	IN
cord-283382-t890r7xp	265	16	which	which	WDT
cord-283382-t890r7xp	265	17	a	a	DT
cord-283382-t890r7xp	265	18	model	model	NN
cord-283382-t890r7xp	265	19	antigen	antigen	NN
cord-283382-t890r7xp	265	20	,	,	,
cord-283382-t890r7xp	265	21	enhanced	enhance	VBN
cord-283382-t890r7xp	265	22	green	green	JJ
cord-283382-t890r7xp	265	23	fluorescent	fluorescent	NN
cord-283382-t890r7xp	265	24	protein	protein	NN
cord-283382-t890r7xp	265	25	(	(	-LRB-
cord-283382-t890r7xp	265	26	EGFP	EGFP	NNP
cord-283382-t890r7xp	265	27	)	)	-RRB-
cord-283382-t890r7xp	265	28	,	,	,
cord-283382-t890r7xp	265	29	is	be	VBZ
cord-283382-t890r7xp	265	30	fused	fuse	VBN
cord-283382-t890r7xp	265	31	to	to	IN
cord-283382-t890r7xp	265	32	a	a	DT
cord-283382-t890r7xp	265	33	protein	protein	NN
cord-283382-t890r7xp	265	34	domain	domain	NN
cord-283382-t890r7xp	265	35	known	know	VBN
cord-283382-t890r7xp	265	36	to	to	TO
cord-283382-t890r7xp	265	37	tether	tether	VB
cord-283382-t890r7xp	265	38	proteins	protein	NNS
cord-283382-t890r7xp	265	39	to	to	IN
cord-283382-t890r7xp	265	40	the	the	DT
cord-283382-t890r7xp	265	41	surface	surface	NN
cord-283382-t890r7xp	265	42	of	of	IN
cord-283382-t890r7xp	265	43	extracellular	extracellular	JJ
cord-283382-t890r7xp	265	44	vesicles	vesicle	NNS
cord-283382-t890r7xp	265	45	(	(	-LRB-
cord-283382-t890r7xp	265	46	EVs	ev	NNS
cord-283382-t890r7xp	265	47	)	)	-RRB-
cord-283382-t890r7xp	265	48	,	,	,
cord-283382-t890r7xp	265	49	can	can	MD
cord-283382-t890r7xp	265	50	dramatically	dramatically	RB
cord-283382-t890r7xp	265	51	improve	improve	VB
cord-283382-t890r7xp	265	52	the	the	DT
cord-283382-t890r7xp	265	53	humoral	humoral	JJ
cord-283382-t890r7xp	265	54	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	265	55	of	of	IN
cord-283382-t890r7xp	265	56	both	both	DT
cord-283382-t890r7xp	265	57	Ad5	ad5	CD
cord-283382-t890r7xp	265	58	and	and	CC
cord-283382-t890r7xp	265	59	chimpanzee	chimpanzee	NN
cord-283382-t890r7xp	265	60	Ad	ad	NN
cord-283382-t890r7xp	265	61	vector	vector	NN
cord-283382-t890r7xp	265	62	ChAdOx1	ChAdOx1	NNP
cord-283382-t890r7xp	265	63	in	in	IN
cord-283382-t890r7xp	265	64	mice	mouse	NNS
cord-283382-t890r7xp	265	65	following	follow	VBG
cord-283382-t890r7xp	265	66	i.m	i.m	NNP
cord-283382-t890r7xp	265	67	.	.	NNP
cord-283382-t890r7xp	265	68	and	and	CC
cord-283382-t890r7xp	265	69	i.n	i.n	NNP
cord-283382-t890r7xp	265	70	vaccination	vaccination	NN
cord-283382-t890r7xp	265	71	.	.	.
cord-283382-t890r7xp	266	1	EVs	ev	NNS
cord-283382-t890r7xp	266	2	play	play	VBP
cord-283382-t890r7xp	266	3	important	important	JJ
cord-283382-t890r7xp	266	4	roles	role	NNS
cord-283382-t890r7xp	266	5	in	in	IN
cord-283382-t890r7xp	266	6	regulating	regulate	VBG
cord-283382-t890r7xp	266	7	immune	immune	JJ
cord-283382-t890r7xp	266	8	responses	response	NNS
cord-283382-t890r7xp	266	9	and	and	CC
cord-283382-t890r7xp	266	10	are	be	VBP
cord-283382-t890r7xp	266	11	conveyors	conveyor	NNS
cord-283382-t890r7xp	266	12	of	of	IN
cord-283382-t890r7xp	266	13	cellular	cellular	JJ
cord-283382-t890r7xp	266	14	communication	communication	NN
cord-283382-t890r7xp	266	15	signals	signal	NNS
cord-283382-t890r7xp	266	16	(	(	-LRB-
cord-283382-t890r7xp	266	17	15	15	CD
cord-283382-t890r7xp	266	18	)	)	-RRB-
cord-283382-t890r7xp	266	19	.	.	.
cord-283382-t890r7xp	267	1	As	as	IN
cord-283382-t890r7xp	267	2	EVs	ev	NNS
cord-283382-t890r7xp	267	3	are	be	VBP
cord-283382-t890r7xp	267	4	frequently	frequently	RB
cord-283382-t890r7xp	267	5	implicated	implicate	VBN
cord-283382-t890r7xp	267	6	in	in	IN
cord-283382-t890r7xp	267	7	host	host	NN
cord-283382-t890r7xp	267	8	-	-	HYPH
cord-283382-t890r7xp	267	9	pathogen	pathogen	NN
cord-283382-t890r7xp	267	10	interactions	interaction	NNS
cord-283382-t890r7xp	267	11	and	and	CC
cord-283382-t890r7xp	267	12	have	have	VBP
cord-283382-t890r7xp	267	13	been	be	VBN
cord-283382-t890r7xp	267	14	shown	show	VBN
cord-283382-t890r7xp	267	15	to	to	TO
cord-283382-t890r7xp	267	16	transfer	transfer	VB
cord-283382-t890r7xp	267	17	antigenic	antigenic	JJ
cord-283382-t890r7xp	267	18	material	material	NN
cord-283382-t890r7xp	267	19	to	to	IN
cord-283382-t890r7xp	267	20	APCs	apc	NNS
cord-283382-t890r7xp	267	21	(	(	-LRB-
cord-283382-t890r7xp	267	22	81	81	CD
cord-283382-t890r7xp	267	23	,	,	,
cord-283382-t890r7xp	267	24	82	82	CD
cord-283382-t890r7xp	267	25	)	)	-RRB-
cord-283382-t890r7xp	267	26	,	,	,
cord-283382-t890r7xp	267	27	we	-PRON-	PRP
cord-283382-t890r7xp	267	28	reasoned	reason	VBD
cord-283382-t890r7xp	267	29	that	that	IN
cord-283382-t890r7xp	267	30	directed	direct	VBD
cord-283382-t890r7xp	267	31	targeting	targeting	NN
cord-283382-t890r7xp	267	32	of	of	IN
cord-283382-t890r7xp	267	33	a	a	DT
cord-283382-t890r7xp	267	34	vaccine	vaccine	NN
cord-283382-t890r7xp	267	35	Ag	Ag	NNP
cord-283382-t890r7xp	267	36	to	to	IN
cord-283382-t890r7xp	267	37	their	-PRON-	PRP$
cord-283382-t890r7xp	267	38	surface	surface	NN
cord-283382-t890r7xp	267	39	could	could	MD
cord-283382-t890r7xp	267	40	potentiate	potentiate	VB
cord-283382-t890r7xp	267	41	immune	immune	JJ
cord-283382-t890r7xp	267	42	responses	response	NNS
cord-283382-t890r7xp	267	43	.	.	.
cord-283382-t890r7xp	268	1	Although	although	IN
cord-283382-t890r7xp	268	2	cellular	cellular	JJ
cord-283382-t890r7xp	268	3	immunity	immunity	NN
cord-283382-t890r7xp	268	4	was	be	VBD
cord-283382-t890r7xp	268	5	largely	largely	RB
cord-283382-t890r7xp	268	6	unaffected	unaffected	JJ
cord-283382-t890r7xp	268	7	,	,	,
cord-283382-t890r7xp	268	8	Ag	Ag	NNP
cord-283382-t890r7xp	268	9	-	-	HYPH
cord-283382-t890r7xp	268	10	specific	specific	JJ
cord-283382-t890r7xp	268	11	humoral	humoral	JJ
cord-283382-t890r7xp	268	12	immune	immune	JJ
cord-283382-t890r7xp	268	13	responses	response	NNS
cord-283382-t890r7xp	268	14	were	be	VBD
cord-283382-t890r7xp	268	15	increased	increase	VBN
cord-283382-t890r7xp	268	16	up	up	IN
cord-283382-t890r7xp	268	17	to	to	IN
cord-283382-t890r7xp	268	18	400-fold	400-fold	CD
cord-283382-t890r7xp	268	19	when	when	WRB
cord-283382-t890r7xp	268	20	compared	compare	VBN
cord-283382-t890r7xp	268	21	with	with	IN
cord-283382-t890r7xp	268	22	unmodified	unmodified	JJ
cord-283382-t890r7xp	268	23	EGFP	EGFP	NNP
cord-283382-t890r7xp	268	24	(	(	-LRB-
cord-283382-t890r7xp	268	25	15	15	CD
cord-283382-t890r7xp	268	26	)	)	-RRB-
cord-283382-t890r7xp	268	27	.	.	.
cord-283382-t890r7xp	269	1	The	the	DT
cord-283382-t890r7xp	269	2	choice	choice	NN
cord-283382-t890r7xp	269	3	of	of	IN
cord-283382-t890r7xp	269	4	molecular	molecular	JJ
cord-283382-t890r7xp	269	5	or	or	CC
cord-283382-t890r7xp	269	6	genetic	genetic	JJ
cord-283382-t890r7xp	269	7	adjuvant	adjuvant	NN
cord-283382-t890r7xp	269	8	will	will	MD
cord-283382-t890r7xp	269	9	depend	depend	VB
cord-283382-t890r7xp	269	10	on	on	IN
cord-283382-t890r7xp	269	11	the	the	DT
cord-283382-t890r7xp	269	12	predicted	predict	VBN
cord-283382-t890r7xp	269	13	correlates	correlate	NNS
cord-283382-t890r7xp	269	14	of	of	IN
cord-283382-t890r7xp	269	15	protection	protection	NN
cord-283382-t890r7xp	269	16	for	for	IN
cord-283382-t890r7xp	269	17	a	a	DT
cord-283382-t890r7xp	269	18	specific	specific	JJ
cord-283382-t890r7xp	269	19	disease	disease	NN
cord-283382-t890r7xp	269	20	target	target	NN
cord-283382-t890r7xp	269	21	:	:	:
cord-283382-t890r7xp	269	22	in	in	IN
cord-283382-t890r7xp	269	23	certain	certain	JJ
cord-283382-t890r7xp	269	24	cases	case	NNS
cord-283382-t890r7xp	269	25	,	,	,
cord-283382-t890r7xp	269	26	a	a	DT
cord-283382-t890r7xp	269	27	robust	robust	JJ
cord-283382-t890r7xp	269	28	humoral	humoral	JJ
cord-283382-t890r7xp	269	29	immune	immune	JJ
cord-283382-t890r7xp	269	30	response	response	NN
cord-283382-t890r7xp	269	31	will	will	MD
cord-283382-t890r7xp	269	32	be	be	VB
cord-283382-t890r7xp	269	33	more	more	RBR
cord-283382-t890r7xp	269	34	important	important	JJ
cord-283382-t890r7xp	269	35	than	than	IN
cord-283382-t890r7xp	269	36	a	a	DT
cord-283382-t890r7xp	269	37	cellular	cellular	JJ
cord-283382-t890r7xp	269	38	immune	immune	JJ
cord-283382-t890r7xp	269	39	response	response	NN
cord-283382-t890r7xp	269	40	.	.	.
cord-283382-t890r7xp	270	1	Further	further	RB
cord-283382-t890r7xp	270	2	to	to	IN
cord-283382-t890r7xp	270	3	this	this	DT
cord-283382-t890r7xp	270	4	,	,	,
cord-283382-t890r7xp	270	5	some	some	DT
cord-283382-t890r7xp	270	6	adjuvanting	adjuvanting	JJ
cord-283382-t890r7xp	270	7	technologies	technology	NNS
cord-283382-t890r7xp	270	8	will	will	MD
cord-283382-t890r7xp	270	9	work	work	VB
cord-283382-t890r7xp	270	10	for	for	IN
cord-283382-t890r7xp	270	11	one	one	CD
cord-283382-t890r7xp	270	12	Ag	Ag	NNP
cord-283382-t890r7xp	270	13	but	but	CC
cord-283382-t890r7xp	270	14	not	not	RB
cord-283382-t890r7xp	270	15	for	for	IN
cord-283382-t890r7xp	270	16	another	another	DT
cord-283382-t890r7xp	270	17	,	,	,
cord-283382-t890r7xp	270	18	and	and	CC
cord-283382-t890r7xp	270	19	structural	structural	JJ
cord-283382-t890r7xp	270	20	constraints	constraint	NNS
cord-283382-t890r7xp	270	21	may	may	MD
cord-283382-t890r7xp	270	22	limit	limit	VB
cord-283382-t890r7xp	270	23	the	the	DT
cord-283382-t890r7xp	270	24	ability	ability	NN
cord-283382-t890r7xp	270	25	to	to	TO
cord-283382-t890r7xp	270	26	modify	modify	VB
cord-283382-t890r7xp	270	27	complex	complex	JJ
cord-283382-t890r7xp	270	28	,	,	,
cord-283382-t890r7xp	270	29	multimeric	multimeric	JJ
cord-283382-t890r7xp	270	30	Ags	Ags	NNP
cord-283382-t890r7xp	270	31	.	.	.
cord-283382-t890r7xp	271	1	This	this	DT
cord-283382-t890r7xp	271	2	will	will	MD
cord-283382-t890r7xp	271	3	require	require	VB
cord-283382-t890r7xp	271	4	the	the	DT
cord-283382-t890r7xp	271	5	optimization	optimization	NN
cord-283382-t890r7xp	271	6	and	and	CC
cord-283382-t890r7xp	271	7	selection	selection	NN
cord-283382-t890r7xp	271	8	of	of	IN
cord-283382-t890r7xp	271	9	different	different	JJ
cord-283382-t890r7xp	271	10	components	component	NNS
cord-283382-t890r7xp	271	11	to	to	TO
cord-283382-t890r7xp	271	12	be	be	VB
cord-283382-t890r7xp	271	13	combined	combine	VBN
cord-283382-t890r7xp	271	14	and	and	CC
cord-283382-t890r7xp	271	15	assembled	assemble	VBN
cord-283382-t890r7xp	271	16	into	into	IN
cord-283382-t890r7xp	271	17	customized	customize	VBN
cord-283382-t890r7xp	271	18	Ad	ad	NN
cord-283382-t890r7xp	271	19	vectors	vector	NNS
cord-283382-t890r7xp	271	20	which	which	WDT
cord-283382-t890r7xp	271	21	are	be	VBP
cord-283382-t890r7xp	271	22	tailored	tailor	VBN
cord-283382-t890r7xp	271	23	to	to	IN
cord-283382-t890r7xp	271	24	specific	specific	JJ
cord-283382-t890r7xp	271	25	pathogens	pathogen	NNS
cord-283382-t890r7xp	271	26	.	.	.
cord-283382-t890r7xp	272	1	Challenges	challenge	VBZ
cord-283382-t890r7xp	272	2	A	a	DT
cord-283382-t890r7xp	272	3	number	number	NN
cord-283382-t890r7xp	272	4	of	of	IN
cord-283382-t890r7xp	272	5	promising	promising	JJ
cord-283382-t890r7xp	272	6	animal	animal	NN
cord-283382-t890r7xp	272	7	studies	study	NNS
cord-283382-t890r7xp	272	8	solidified	solidify	VBD
cord-283382-t890r7xp	272	9	the	the	DT
cord-283382-t890r7xp	272	10	appeal	appeal	NN
cord-283382-t890r7xp	272	11	of	of	IN
cord-283382-t890r7xp	272	12	Ad5	ad5	CD
cord-283382-t890r7xp	272	13	as	as	IN
cord-283382-t890r7xp	272	14	a	a	DT
cord-283382-t890r7xp	272	15	platform	platform	NN
cord-283382-t890r7xp	272	16	vaccine	vaccine	NN
cord-283382-t890r7xp	272	17	vector	vector	NN
cord-283382-t890r7xp	272	18	for	for	IN
cord-283382-t890r7xp	272	19	infectious	infectious	JJ
cord-283382-t890r7xp	272	20	diseases	disease	NNS
cord-283382-t890r7xp	272	21	.	.	.
cord-283382-t890r7xp	273	1	In	in	IN
cord-283382-t890r7xp	273	2	particular	particular	JJ
cord-283382-t890r7xp	273	3	,	,	,
cord-283382-t890r7xp	273	4	a	a	DT
cord-283382-t890r7xp	273	5	study	study	NN
cord-283382-t890r7xp	273	6	by	by	IN
cord-283382-t890r7xp	273	7	Sullivan	Sullivan	NNP
cord-283382-t890r7xp	273	8	et	et	NNP
cord-283382-t890r7xp	273	9	al	al	NNP
cord-283382-t890r7xp	273	10	.	.	NNP
cord-283382-t890r7xp	273	11	demonstrated	demonstrate	VBD
cord-283382-t890r7xp	273	12	that	that	IN
cord-283382-t890r7xp	273	13	a	a	DT
cord-283382-t890r7xp	273	14	singleshot	singleshot	JJ
cord-283382-t890r7xp	273	15	,	,	,
cord-283382-t890r7xp	273	16	low	low	JJ
cord-283382-t890r7xp	273	17	dose	dose	NN
cord-283382-t890r7xp	273	18	(	(	-LRB-
cord-283382-t890r7xp	273	19	1	1	CD
cord-283382-t890r7xp	273	20	×	×	NNP
cord-283382-t890r7xp	273	21	10	10	CD
cord-283382-t890r7xp	273	22	10	10	CD
cord-283382-t890r7xp	273	23	vp	vp	NNP
cord-283382-t890r7xp	273	24	)	)	-RRB-
cord-283382-t890r7xp	273	25	immunization	immunization	NN
cord-283382-t890r7xp	273	26	with	with	IN
cord-283382-t890r7xp	273	27	Ad5	ad5	CD
cord-283382-t890r7xp	273	28	expressing	express	VBG
cord-283382-t890r7xp	273	29	Ebola	Ebola	NNP
cord-283382-t890r7xp	273	30	virus	virus	NN
cord-283382-t890r7xp	273	31	glycoprotein	glycoprotein	NN
cord-283382-t890r7xp	273	32	(	(	-LRB-
cord-283382-t890r7xp	273	33	GP	GP	NNP
cord-283382-t890r7xp	273	34	)	)	-RRB-
cord-283382-t890r7xp	273	35	could	could	MD
cord-283382-t890r7xp	273	36	provide	provide	VB
cord-283382-t890r7xp	273	37	100	100	CD
cord-283382-t890r7xp	273	38	%	%	NN
cord-283382-t890r7xp	273	39	protection	protection	NN
cord-283382-t890r7xp	273	40	from	from	IN
cord-283382-t890r7xp	273	41	challenge	challenge	NN
cord-283382-t890r7xp	273	42	in	in	IN
cord-283382-t890r7xp	273	43	NHPs	nhp	NNS
cord-283382-t890r7xp	273	44	(	(	-LRB-
cord-283382-t890r7xp	273	45	160	160	CD
cord-283382-t890r7xp	273	46	)	)	-RRB-
cord-283382-t890r7xp	273	47	.	.	.
cord-283382-t890r7xp	274	1	Similar	similar	JJ
cord-283382-t890r7xp	274	2	studies	study	NNS
cord-283382-t890r7xp	274	3	using	use	VBG
cord-283382-t890r7xp	274	4	Ad5	Ad5	NNP
cord-283382-t890r7xp	274	5	based	base	VBN
cord-283382-t890r7xp	274	6	vectors	vector	NNS
cord-283382-t890r7xp	274	7	expressing	express	VBG
cord-283382-t890r7xp	274	8	SIV	SIV	NNP
cord-283382-t890r7xp	274	9	gag	gag	NN
cord-283382-t890r7xp	274	10	demonstrated	demonstrate	VBD
cord-283382-t890r7xp	274	11	its	-PRON-	PRP$
cord-283382-t890r7xp	274	12	superiority	superiority	NN
cord-283382-t890r7xp	274	13	to	to	IN
cord-283382-t890r7xp	274	14	plasmid	plasmid	NN
cord-283382-t890r7xp	274	15	DNA	dna	NN
cord-283382-t890r7xp	274	16	or	or	CC
cord-283382-t890r7xp	274	17	modified	modify	VBN
cord-283382-t890r7xp	274	18	vaccinia	vaccinia	NN
cord-283382-t890r7xp	274	19	Ankara	Ankara	NNP
cord-283382-t890r7xp	274	20	(	(	-LRB-
cord-283382-t890r7xp	274	21	MVA	MVA	NNP
cord-283382-t890r7xp	274	22	)	)	-RRB-
cord-283382-t890r7xp	274	23	in	in	IN
cord-283382-t890r7xp	274	24	attenuating	attenuate	VBG
cord-283382-t890r7xp	274	25	viremia	viremia	NN
cord-283382-t890r7xp	274	26	following	follow	VBG
cord-283382-t890r7xp	274	27	virus	virus	NN
cord-283382-t890r7xp	274	28	challenge	challenge	NN
cord-283382-t890r7xp	274	29	(	(	-LRB-
cord-283382-t890r7xp	274	30	12	12	CD
cord-283382-t890r7xp	274	31	)	)	-RRB-
cord-283382-t890r7xp	274	32	.	.	.
cord-283382-t890r7xp	275	1	On	on	IN
cord-283382-t890r7xp	275	2	the	the	DT
cord-283382-t890r7xp	275	3	basis	basis	NN
cord-283382-t890r7xp	275	4	of	of	IN
cord-283382-t890r7xp	275	5	these	these	DT
cord-283382-t890r7xp	275	6	promising	promising	JJ
cord-283382-t890r7xp	275	7	early	early	JJ
cord-283382-t890r7xp	275	8	results	result	NNS
cord-283382-t890r7xp	275	9	,	,	,
cord-283382-t890r7xp	275	10	a	a	DT
cord-283382-t890r7xp	275	11	multicenter	multicenter	JJ
cord-283382-t890r7xp	275	12	Phase	Phase	NNP
cord-283382-t890r7xp	275	13	II	II	NNP
cord-283382-t890r7xp	275	14	clinical	clinical	JJ
cord-283382-t890r7xp	275	15	trial	trial	NN
cord-283382-t890r7xp	275	16	called	call	VBN
cord-283382-t890r7xp	275	17	the	the	DT
cord-283382-t890r7xp	275	18	Merck	Merck	NNP
cord-283382-t890r7xp	275	19	STEP	STEP	NNP
cord-283382-t890r7xp	275	20	study	study	NN
cord-283382-t890r7xp	275	21	was	be	VBD
cord-283382-t890r7xp	275	22	initiated	initiate	VBN
cord-283382-t890r7xp	275	23	,	,	,
cord-283382-t890r7xp	275	24	in	in	IN
cord-283382-t890r7xp	275	25	which	which	WDT
cord-283382-t890r7xp	275	26	a	a	DT
cord-283382-t890r7xp	275	27	vaccine	vaccine	NN
cord-283382-t890r7xp	275	28	composed	compose	VBN
cord-283382-t890r7xp	275	29	of	of	IN
cord-283382-t890r7xp	275	30	a	a	DT
cord-283382-t890r7xp	275	31	mixture	mixture	NN
cord-283382-t890r7xp	275	32	of	of	IN
cord-283382-t890r7xp	275	33	Ad5	ad5	CD
cord-283382-t890r7xp	275	34	vectors	vector	NNS
cord-283382-t890r7xp	275	35	expressing	express	VBG
cord-283382-t890r7xp	275	36	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	275	37	gag	gag	NN
cord-283382-t890r7xp	275	38	,	,	,
cord-283382-t890r7xp	275	39	pol	pol	NN
cord-283382-t890r7xp	275	40	,	,	,
cord-283382-t890r7xp	275	41	and	and	CC
cord-283382-t890r7xp	275	42	nef	nef	NNP
cord-283382-t890r7xp	275	43	genes	gene	NNS
cord-283382-t890r7xp	275	44	was	be	VBD
cord-283382-t890r7xp	275	45	administered	administer	VBN
cord-283382-t890r7xp	275	46	to	to	IN
cord-283382-t890r7xp	275	47	participants	participant	NNS
cord-283382-t890r7xp	275	48	at	at	IN
cord-283382-t890r7xp	275	49	high	high	JJ
cord-283382-t890r7xp	275	50	risk	risk	NN
cord-283382-t890r7xp	275	51	for	for	IN
cord-283382-t890r7xp	275	52	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	275	53	acquisition	acquisition	NN
cord-283382-t890r7xp	275	54	(	(	-LRB-
cord-283382-t890r7xp	275	55	161	161	CD
cord-283382-t890r7xp	275	56	,	,	,
cord-283382-t890r7xp	275	57	162	162	CD
cord-283382-t890r7xp	275	58	)	)	-RRB-
cord-283382-t890r7xp	275	59	.	.	.
cord-283382-t890r7xp	276	1	Phase	phase	NN
cord-283382-t890r7xp	276	2	I	-PRON-	PRP
cord-283382-t890r7xp	276	3	safety	safety	NN
cord-283382-t890r7xp	276	4	and	and	CC
cord-283382-t890r7xp	276	5	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	276	6	studies	study	NNS
cord-283382-t890r7xp	276	7	in	in	IN
cord-283382-t890r7xp	276	8	healthy	healthy	JJ
cord-283382-t890r7xp	277	1	,	,	,
cord-283382-t890r7xp	277	2	HIV	HIV	NNP
cord-283382-t890r7xp	277	3	-	-	HYPH
cord-283382-t890r7xp	277	4	seronegative	seronegative	JJ
cord-283382-t890r7xp	277	5	adults	adult	NNS
cord-283382-t890r7xp	277	6	showed	show	VBD
cord-283382-t890r7xp	277	7	that	that	IN
cord-283382-t890r7xp	277	8	this	this	DT
cord-283382-t890r7xp	277	9	vaccine	vaccine	NN
cord-283382-t890r7xp	277	10	could	could	MD
cord-283382-t890r7xp	277	11	elicit	elicit	VB
cord-283382-t890r7xp	277	12	antigen	antigen	NN
cord-283382-t890r7xp	277	13	-	-	HYPH
cord-283382-t890r7xp	277	14	specific	specific	JJ
cord-283382-t890r7xp	277	15	IFN	IFN	NNP
cord-283382-t890r7xp	277	16	-	-	HYPH
cord-283382-t890r7xp	277	17	γ	γ	NN
cord-283382-t890r7xp	277	18	ELISpot	elispot	NN
cord-283382-t890r7xp	277	19	responses	response	NNS
cord-283382-t890r7xp	277	20	in	in	IN
cord-283382-t890r7xp	277	21	both	both	DT
cord-283382-t890r7xp	277	22	Ad5	ad5	CD
cord-283382-t890r7xp	277	23	seronegative	seronegative	JJ
cord-283382-t890r7xp	277	24	and	and	CC
cord-283382-t890r7xp	277	25	seropositive	seropositive	JJ
cord-283382-t890r7xp	277	26	individuals	individual	NNS
cord-283382-t890r7xp	277	27	(	(	-LRB-
cord-283382-t890r7xp	277	28	163	163	CD
cord-283382-t890r7xp	277	29	)	)	-RRB-
cord-283382-t890r7xp	277	30	.	.	.
cord-283382-t890r7xp	278	1	However	however	RB
cord-283382-t890r7xp	278	2	,	,	,
cord-283382-t890r7xp	278	3	the	the	DT
cord-283382-t890r7xp	278	4	Phase	Phase	NNP
cord-283382-t890r7xp	278	5	II	II	NNP
cord-283382-t890r7xp	278	6	study	study	NN
cord-283382-t890r7xp	278	7	was	be	VBD
cord-283382-t890r7xp	278	8	terminated	terminate	VBN
cord-283382-t890r7xp	278	9	prematurely	prematurely	RB
cord-283382-t890r7xp	278	10	due	due	IN
cord-283382-t890r7xp	278	11	to	to	IN
cord-283382-t890r7xp	278	12	futility	futility	NN
cord-283382-t890r7xp	278	13	and	and	CC
cord-283382-t890r7xp	278	14	failure	failure	NN
cord-283382-t890r7xp	278	15	to	to	TO
cord-283382-t890r7xp	278	16	meet	meet	VB
cord-283382-t890r7xp	278	17	pre	pre	JJ
cord-283382-t890r7xp	278	18	-	-	JJ
cord-283382-t890r7xp	278	19	defined	define	VBN
cord-283382-t890r7xp	278	20	endpoints	endpoint	NNS
cord-283382-t890r7xp	278	21	:	:	:
cord-283382-t890r7xp	278	22	an	an	DT
cord-283382-t890r7xp	278	23	interim	interim	JJ
cord-283382-t890r7xp	278	24	analysis	analysis	NN
cord-283382-t890r7xp	278	25	determined	determine	VBD
cord-283382-t890r7xp	278	26	that	that	IN
cord-283382-t890r7xp	278	27	the	the	DT
cord-283382-t890r7xp	278	28	vaccine	vaccine	NN
cord-283382-t890r7xp	278	29	would	would	MD
cord-283382-t890r7xp	278	30	not	not	RB
cord-283382-t890r7xp	278	31	be	be	VB
cord-283382-t890r7xp	278	32	efficacious	efficacious	JJ
cord-283382-t890r7xp	278	33	in	in	IN
cord-283382-t890r7xp	278	34	preventing	prevent	VBG
cord-283382-t890r7xp	278	35	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	278	36	infection	infection	NN
cord-283382-t890r7xp	278	37	,	,	,
cord-283382-t890r7xp	278	38	or	or	CC
cord-283382-t890r7xp	278	39	in	in	IN
cord-283382-t890r7xp	278	40	reducing	reduce	VBG
cord-283382-t890r7xp	278	41	viral	viral	JJ
cord-283382-t890r7xp	278	42	-	-	HYPH
cord-283382-t890r7xp	278	43	load	load	NN
cord-283382-t890r7xp	278	44	setpoint	setpoint	NN
cord-283382-t890r7xp	278	45	in	in	IN
cord-283382-t890r7xp	278	46	seroconverters	seroconverter	NNS
cord-283382-t890r7xp	278	47	,	,	,
cord-283382-t890r7xp	278	48	despite	despite	IN
cord-283382-t890r7xp	278	49	eliciting	elicit	VBG
cord-283382-t890r7xp	278	50	T	t	NN
cord-283382-t890r7xp	278	51	cell	cell	NN
cord-283382-t890r7xp	278	52	responses	response	NNS
cord-283382-t890r7xp	278	53	in	in	IN
cord-283382-t890r7xp	278	54	most	most	JJS
cord-283382-t890r7xp	278	55	participants	participant	NNS
cord-283382-t890r7xp	278	56	(	(	-LRB-
cord-283382-t890r7xp	278	57	162	162	CD
cord-283382-t890r7xp	278	58	,	,	,
cord-283382-t890r7xp	278	59	163	163	CD
cord-283382-t890r7xp	278	60	)	)	-RRB-
cord-283382-t890r7xp	278	61	.	.	.
cord-283382-t890r7xp	279	1	Subsequent	subsequent	JJ
cord-283382-t890r7xp	279	2	to	to	IN
cord-283382-t890r7xp	279	3	this	this	DT
cord-283382-t890r7xp	279	4	,	,	,
cord-283382-t890r7xp	279	5	a	a	DT
cord-283382-t890r7xp	279	6	post	post	JJ
cord-283382-t890r7xp	279	7	-	-	JJ
cord-283382-t890r7xp	279	8	hoc	hoc	JJ
cord-283382-t890r7xp	279	9	analysis	analysis	NN
cord-283382-t890r7xp	279	10	of	of	IN
cord-283382-t890r7xp	279	11	the	the	DT
cord-283382-t890r7xp	279	12	study	study	NN
cord-283382-t890r7xp	279	13	suggested	suggest	VBD
cord-283382-t890r7xp	279	14	an	an	DT
cord-283382-t890r7xp	279	15	association	association	NN
cord-283382-t890r7xp	279	16	between	between	IN
cord-283382-t890r7xp	279	17	vaccination	vaccination	NN
cord-283382-t890r7xp	279	18	with	with	IN
cord-283382-t890r7xp	279	19	the	the	DT
cord-283382-t890r7xp	279	20	Ad5	ad5	CD
cord-283382-t890r7xp	279	21	vaccine	vaccine	NN
cord-283382-t890r7xp	279	22	and	and	CC
cord-283382-t890r7xp	279	23	increased	increase	VBN
cord-283382-t890r7xp	279	24	acquisition	acquisition	NN
cord-283382-t890r7xp	279	25	of	of	IN
cord-283382-t890r7xp	279	26	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	279	27	(	(	-LRB-
cord-283382-t890r7xp	279	28	161	161	CD
cord-283382-t890r7xp	279	29	)	)	-RRB-
cord-283382-t890r7xp	279	30	.	.	.
cord-283382-t890r7xp	280	1	On	on	IN
cord-283382-t890r7xp	280	2	multivariate	multivariate	JJ
cord-283382-t890r7xp	280	3	analyses	analysis	NNS
cord-283382-t890r7xp	280	4	,	,	,
cord-283382-t890r7xp	280	5	this	this	DT
cord-283382-t890r7xp	280	6	increase	increase	NN
cord-283382-t890r7xp	280	7	was	be	VBD
cord-283382-t890r7xp	280	8	largely	largely	RB
cord-283382-t890r7xp	280	9	restricted	restrict	VBN
cord-283382-t890r7xp	280	10	to	to	IN
cord-283382-t890r7xp	280	11	a	a	DT
cord-283382-t890r7xp	280	12	defined	define	VBN
cord-283382-t890r7xp	280	13	sub	sub	NN
cord-283382-t890r7xp	280	14	-	-	JJ
cord-283382-t890r7xp	280	15	set	set	NN
cord-283382-t890r7xp	280	16	of	of	IN
cord-283382-t890r7xp	280	17	participants	participant	NNS
cord-283382-t890r7xp	280	18	:	:	:
cord-283382-t890r7xp	280	19	uncircumcised	uncircumcised	JJ
cord-283382-t890r7xp	280	20	men	man	NNS
cord-283382-t890r7xp	280	21	with	with	IN
cord-283382-t890r7xp	280	22	high	high	JJ
cord-283382-t890r7xp	280	23	baseline	baseline	JJ
cord-283382-t890r7xp	280	24	antibody	antibody	NN
cord-283382-t890r7xp	280	25	titers	titer	NNS
cord-283382-t890r7xp	280	26	against	against	IN
cord-283382-t890r7xp	280	27	Ad5	ad5	CD
cord-283382-t890r7xp	280	28	.	.	.
cord-283382-t890r7xp	281	1	Several	several	JJ
cord-283382-t890r7xp	281	2	hypotheses	hypothesis	NNS
cord-283382-t890r7xp	281	3	were	be	VBD
cord-283382-t890r7xp	281	4	proposed	propose	VBN
cord-283382-t890r7xp	281	5	to	to	TO
cord-283382-t890r7xp	281	6	explain	explain	VB
cord-283382-t890r7xp	281	7	the	the	DT
cord-283382-t890r7xp	281	8	increase	increase	NN
cord-283382-t890r7xp	281	9	in	in	IN
cord-283382-t890r7xp	281	10	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	281	11	acquisition	acquisition	NN
cord-283382-t890r7xp	281	12	,	,	,
cord-283382-t890r7xp	281	13	including	include	VBG
cord-283382-t890r7xp	281	14	the	the	DT
cord-283382-t890r7xp	281	15	formation	formation	NN
cord-283382-t890r7xp	281	16	of	of	IN
cord-283382-t890r7xp	281	17	immune	immune	JJ
cord-283382-t890r7xp	281	18	complexes	complex	NNS
cord-283382-t890r7xp	281	19	(	(	-LRB-
cord-283382-t890r7xp	281	20	IC	IC	NNP
cord-283382-t890r7xp	281	21	)	)	-RRB-
cord-283382-t890r7xp	281	22	between	between	IN
cord-283382-t890r7xp	281	23	anti	anti	JJ
cord-283382-t890r7xp	281	24	-	-	JJ
cord-283382-t890r7xp	281	25	Ad5	ad5	JJ
cord-283382-t890r7xp	281	26	antibodies	antibody	NNS
cord-283382-t890r7xp	281	27	and	and	CC
cord-283382-t890r7xp	281	28	DCs	DCs	NNP
cord-283382-t890r7xp	281	29	,	,	,
cord-283382-t890r7xp	281	30	which	which	WDT
cord-283382-t890r7xp	281	31	were	be	VBD
cord-283382-t890r7xp	281	32	shown	show	VBN
cord-283382-t890r7xp	281	33	to	to	TO
cord-283382-t890r7xp	281	34	enhance	enhance	VB
cord-283382-t890r7xp	281	35	HIV-1infection	hiv-1infection	NN
cord-283382-t890r7xp	281	36	of	of	IN
cord-283382-t890r7xp	281	37	T	t	NN
cord-283382-t890r7xp	281	38	cells	cell	NNS
cord-283382-t890r7xp	281	39	in	in	IN
cord-283382-t890r7xp	281	40	DC	DC	NNP
cord-283382-t890r7xp	281	41	-	-	HYPH
cord-283382-t890r7xp	281	42	T	T	NNP
cord-283382-t890r7xp	281	43	cell	cell	NN
cord-283382-t890r7xp	281	44	co	co	NNS
cord-283382-t890r7xp	281	45	-	-	NNS
cord-283382-t890r7xp	281	46	cultures	culture	NNS
cord-283382-t890r7xp	281	47	in	in	IN
cord-283382-t890r7xp	281	48	vitro	vitro	FW
cord-283382-t890r7xp	281	49	(	(	-LRB-
cord-283382-t890r7xp	281	50	164	164	CD
cord-283382-t890r7xp	281	51	)	)	-RRB-
cord-283382-t890r7xp	281	52	.	.	.
cord-283382-t890r7xp	282	1	An	an	DT
cord-283382-t890r7xp	282	2	alternative	alternative	JJ
cord-283382-t890r7xp	282	3	hypothesis	hypothesis	NN
cord-283382-t890r7xp	282	4	suggested	suggest	VBD
cord-283382-t890r7xp	282	5	that	that	IN
cord-283382-t890r7xp	282	6	Ad5	ad5	CD
cord-283382-t890r7xp	282	7	immunization	immunization	NN
cord-283382-t890r7xp	282	8	induced	induce	VBD
cord-283382-t890r7xp	282	9	the	the	DT
cord-283382-t890r7xp	282	10	expansion	expansion	NN
cord-283382-t890r7xp	282	11	of	of	IN
cord-283382-t890r7xp	282	12	Ad	ad	NN
cord-283382-t890r7xp	282	13	-	-	HYPH
cord-283382-t890r7xp	282	14	specific	specific	JJ
cord-283382-t890r7xp	282	15	memory	memory	NN
cord-283382-t890r7xp	282	16	CD4	CD4	NNP
cord-283382-t890r7xp	282	17	+	+	CC
cord-283382-t890r7xp	282	18	T	t	NN
cord-283382-t890r7xp	282	19	cells	cell	NNS
cord-283382-t890r7xp	282	20	which	which	WDT
cord-283382-t890r7xp	282	21	upregulate	upregulate	VBP
cord-283382-t890r7xp	282	22	CCR5	ccr5	JJ
cord-283382-t890r7xp	282	23	expression	expression	NN
cord-283382-t890r7xp	282	24	and/or	and/or	CC
cord-283382-t890r7xp	282	25	homing	homing	NN
cord-283382-t890r7xp	282	26	markers	marker	NNS
cord-283382-t890r7xp	282	27	for	for	IN
cord-283382-t890r7xp	282	28	mucosal	mucosal	JJ
cord-283382-t890r7xp	282	29	sites	site	NNS
cord-283382-t890r7xp	282	30	,	,	,
cord-283382-t890r7xp	282	31	thereby	thereby	RB
cord-283382-t890r7xp	282	32	increasing	increase	VBG
cord-283382-t890r7xp	282	33	the	the	DT
cord-283382-t890r7xp	282	34	pool	pool	NN
cord-283382-t890r7xp	282	35	of	of	IN
cord-283382-t890r7xp	282	36	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	282	37	susceptible	susceptible	JJ
cord-283382-t890r7xp	282	38	cells	cell	NNS
cord-283382-t890r7xp	282	39	at	at	IN
cord-283382-t890r7xp	282	40	the	the	DT
cord-283382-t890r7xp	282	41	site	site	NN
cord-283382-t890r7xp	282	42	of	of	IN
cord-283382-t890r7xp	282	43	infection	infection	NN
cord-283382-t890r7xp	282	44	(	(	-LRB-
cord-283382-t890r7xp	282	45	165	165	CD
cord-283382-t890r7xp	282	46	)	)	-RRB-
cord-283382-t890r7xp	282	47	.	.	.
cord-283382-t890r7xp	283	1	Although	although	IN
cord-283382-t890r7xp	283	2	the	the	DT
cord-283382-t890r7xp	283	3	latter	latter	JJ
cord-283382-t890r7xp	283	4	hypothesis	hypothesis	NN
cord-283382-t890r7xp	283	5	has	have	VBZ
cord-283382-t890r7xp	283	6	been	be	VBN
cord-283382-t890r7xp	283	7	challenged	challenge	VBN
cord-283382-t890r7xp	283	8	(	(	-LRB-
cord-283382-t890r7xp	283	9	166	166	CD
cord-283382-t890r7xp	283	10	)	)	-RRB-
cord-283382-t890r7xp	283	11	,	,	,
cord-283382-t890r7xp	283	12	the	the	DT
cord-283382-t890r7xp	283	13	precise	precise	JJ
cord-283382-t890r7xp	283	14	mechanisms	mechanism	NNS
cord-283382-t890r7xp	283	15	underlying	underlie	VBG
cord-283382-t890r7xp	283	16	the	the	DT
cord-283382-t890r7xp	283	17	increased	increase	VBN
cord-283382-t890r7xp	283	18	acquisition	acquisition	NN
cord-283382-t890r7xp	283	19	of	of	IN
cord-283382-t890r7xp	283	20	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	283	21	in	in	IN
cord-283382-t890r7xp	283	22	the	the	DT
cord-283382-t890r7xp	283	23	Merck	Merck	NNP
cord-283382-t890r7xp	283	24	Step	Step	NNP
cord-283382-t890r7xp	283	25	trial	trial	NN
cord-283382-t890r7xp	283	26	remain	remain	VBP
cord-283382-t890r7xp	283	27	inconclusive	inconclusive	JJ
cord-283382-t890r7xp	283	28	(	(	-LRB-
cord-283382-t890r7xp	283	29	166	166	CD
cord-283382-t890r7xp	283	30	)	)	-RRB-
cord-283382-t890r7xp	283	31	.	.	.
cord-283382-t890r7xp	284	1	However	however	RB
cord-283382-t890r7xp	284	2	,	,	,
cord-283382-t890r7xp	284	3	it	-PRON-	PRP
cord-283382-t890r7xp	284	4	is	be	VBZ
cord-283382-t890r7xp	284	5	important	important	JJ
cord-283382-t890r7xp	284	6	to	to	TO
cord-283382-t890r7xp	284	7	note	note	VB
cord-283382-t890r7xp	284	8	that	that	IN
cord-283382-t890r7xp	284	9	the	the	DT
cord-283382-t890r7xp	284	10	effects	effect	NNS
cord-283382-t890r7xp	284	11	were	be	VBD
cord-283382-t890r7xp	284	12	shown	show	VBN
cord-283382-t890r7xp	284	13	to	to	TO
cord-283382-t890r7xp	284	14	wane	wane	VB
cord-283382-t890r7xp	284	15	over	over	IN
cord-283382-t890r7xp	284	16	time	time	NN
cord-283382-t890r7xp	284	17	(	(	-LRB-
cord-283382-t890r7xp	284	18	167	167	CD
cord-283382-t890r7xp	284	19	)	)	-RRB-
cord-283382-t890r7xp	284	20	.	.	.
cord-283382-t890r7xp	285	1	Nonetheless	nonetheless	RB
cord-283382-t890r7xp	285	2	,	,	,
cord-283382-t890r7xp	285	3	this	this	DT
cord-283382-t890r7xp	285	4	outcome	outcome	NN
cord-283382-t890r7xp	285	5	led	lead	VBD
cord-283382-t890r7xp	285	6	to	to	IN
cord-283382-t890r7xp	285	7	a	a	DT
cord-283382-t890r7xp	285	8	dampening	dampening	NN
cord-283382-t890r7xp	285	9	in	in	IN
cord-283382-t890r7xp	285	10	enthusiasm	enthusiasm	NN
cord-283382-t890r7xp	285	11	for	for	IN
cord-283382-t890r7xp	285	12	the	the	DT
cord-283382-t890r7xp	285	13	broad	broad	JJ
cord-283382-t890r7xp	285	14	application	application	NN
cord-283382-t890r7xp	285	15	of	of	IN
cord-283382-t890r7xp	285	16	Ad5-based	ad5-based	JJ
cord-283382-t890r7xp	285	17	vaccines	vaccine	NNS
cord-283382-t890r7xp	285	18	for	for	IN
cord-283382-t890r7xp	285	19	major	major	JJ
cord-283382-t890r7xp	285	20	infectious	infectious	JJ
cord-283382-t890r7xp	285	21	diseases	disease	NNS
cord-283382-t890r7xp	285	22	,	,	,
cord-283382-t890r7xp	285	23	prompting	prompt	VBG
cord-283382-t890r7xp	285	24	the	the	DT
cord-283382-t890r7xp	285	25	investigation	investigation	NN
cord-283382-t890r7xp	285	26	of	of	IN
cord-283382-t890r7xp	285	27	novel	novel	JJ
cord-283382-t890r7xp	285	28	rare	rare	JJ
cord-283382-t890r7xp	285	29	species	specie	NNS
cord-283382-t890r7xp	285	30	human	human	JJ
cord-283382-t890r7xp	285	31	or	or	CC
cord-283382-t890r7xp	285	32	non	non	JJ
cord-283382-t890r7xp	285	33	-	-	JJ
cord-283382-t890r7xp	285	34	human	human	JJ
cord-283382-t890r7xp	285	35	Ad	ad	NN
cord-283382-t890r7xp	285	36	viruses	virus	NNS
cord-283382-t890r7xp	285	37	as	as	IN
cord-283382-t890r7xp	285	38	alternative	alternative	JJ
cord-283382-t890r7xp	285	39	vaccine	vaccine	NN
cord-283382-t890r7xp	285	40	platforms	platform	NNS
cord-283382-t890r7xp	285	41	.	.	.
cord-283382-t890r7xp	286	1	Several	several	JJ
cord-283382-t890r7xp	286	2	rare	rare	JJ
cord-283382-t890r7xp	286	3	species	specie	NNS
cord-283382-t890r7xp	286	4	or	or	CC
cord-283382-t890r7xp	286	5	non	non	JJ
cord-283382-t890r7xp	286	6	-	-	JJ
cord-283382-t890r7xp	286	7	human	human	JJ
cord-283382-t890r7xp	286	8	Ad	ad	NN
cord-283382-t890r7xp	286	9	vaccines	vaccine	NNS
cord-283382-t890r7xp	286	10	are	be	VBP
cord-283382-t890r7xp	286	11	now	now	RB
cord-283382-t890r7xp	286	12	leading	lead	VBG
cord-283382-t890r7xp	286	13	the	the	DT
cord-283382-t890r7xp	286	14	way	way	NN
cord-283382-t890r7xp	286	15	in	in	IN
cord-283382-t890r7xp	286	16	human	human	JJ
cord-283382-t890r7xp	286	17	clinical	clinical	JJ
cord-283382-t890r7xp	286	18	trials	trial	NNS
cord-283382-t890r7xp	286	19	,	,	,
cord-283382-t890r7xp	286	20	namely	namely	RB
cord-283382-t890r7xp	286	21	species	specie	NNS
cord-283382-t890r7xp	286	22	C	c	NN
cord-283382-t890r7xp	286	23	vector	vector	NN
cord-283382-t890r7xp	286	24	HAdV	HAdV	NNP
cord-283382-t890r7xp	286	25	-	-	HYPH
cord-283382-t890r7xp	286	26	C6	C6	NNP
cord-283382-t890r7xp	286	27	and	and	CC
cord-283382-t890r7xp	286	28	species	species	NN
cord-283382-t890r7xp	286	29	D	d	NN
cord-283382-t890r7xp	286	30	vector	vector	NN
cord-283382-t890r7xp	286	31	HAdV-26	HAdV-26	NNP
cord-283382-t890r7xp	286	32	,	,	,
cord-283382-t890r7xp	286	33	as	as	RB
cord-283382-t890r7xp	286	34	well	well	RB
cord-283382-t890r7xp	286	35	as	as	IN
cord-283382-t890r7xp	286	36	chimpanzee	chimpanzee	NN
cord-283382-t890r7xp	286	37	Ad	ad	NN
cord-283382-t890r7xp	286	38	vectors	vector	NNS
cord-283382-t890r7xp	286	39	ChAdV-3	ChAdV-3	NNP
cord-283382-t890r7xp	286	40	,	,	,
cord-283382-t890r7xp	286	41	PanAdV-3	PanAdV-3	NNP
cord-283382-t890r7xp	286	42	,	,	,
cord-283382-t890r7xp	286	43	ChAdV-63	ChAdV-63	NNP
cord-283382-t890r7xp	286	44	,	,	,
cord-283382-t890r7xp	286	45	and	and	CC
cord-283382-t890r7xp	286	46	ChAdOx1	ChAdOx1	NNP
cord-283382-t890r7xp	286	47	,	,	,
cord-283382-t890r7xp	286	48	which	which	WDT
cord-283382-t890r7xp	286	49	cluster	cluster	VBP
cord-283382-t890r7xp	286	50	phylogenetically	phylogenetically	RB
cord-283382-t890r7xp	286	51	with	with	IN
cord-283382-t890r7xp	286	52	species	specie	NNS
cord-283382-t890r7xp	286	53	C	c	NN
cord-283382-t890r7xp	286	54	or	or	CC
cord-283382-t890r7xp	286	55	E	e	NN
cord-283382-t890r7xp	286	56	human	human	JJ
cord-283382-t890r7xp	286	57	Ads	ad	NNS
cord-283382-t890r7xp	286	58	(	(	-LRB-
cord-283382-t890r7xp	286	59	see	see	VB
cord-283382-t890r7xp	286	60	Table	table	NN
cord-283382-t890r7xp	286	61	1	1	CD
cord-283382-t890r7xp	286	62	)	)	-RRB-
cord-283382-t890r7xp	286	63	.	.	.
cord-283382-t890r7xp	287	1	Many	many	JJ
cord-283382-t890r7xp	287	2	of	of	IN
cord-283382-t890r7xp	287	3	these	these	DT
cord-283382-t890r7xp	287	4	vector	vector	NN
cord-283382-t890r7xp	287	5	candidates	candidate	NNS
cord-283382-t890r7xp	287	6	had	have	VBD
cord-283382-t890r7xp	287	7	previously	previously	RB
cord-283382-t890r7xp	287	8	been	be	VBN
cord-283382-t890r7xp	287	9	identified	identify	VBN
cord-283382-t890r7xp	287	10	in	in	IN
cord-283382-t890r7xp	287	11	animal	animal	NN
cord-283382-t890r7xp	287	12	studies	study	NNS
cord-283382-t890r7xp	287	13	as	as	IN
cord-283382-t890r7xp	287	14	being	be	VBG
cord-283382-t890r7xp	287	15	potently	potently	RB
cord-283382-t890r7xp	287	16	immunogenic	immunogenic	JJ
cord-283382-t890r7xp	287	17	,	,	,
cord-283382-t890r7xp	287	18	and	and	CC
cord-283382-t890r7xp	287	19	in	in	IN
cord-283382-t890r7xp	287	20	some	some	DT
cord-283382-t890r7xp	287	21	cases	case	NNS
cord-283382-t890r7xp	287	22	were	be	VBD
cord-283382-t890r7xp	287	23	comparable	comparable	JJ
cord-283382-t890r7xp	287	24	to	to	IN
cord-283382-t890r7xp	287	25	the	the	DT
cord-283382-t890r7xp	287	26	potency	potency	NN
cord-283382-t890r7xp	287	27	of	of	IN
cord-283382-t890r7xp	287	28	Ad5	Ad5	NNP
cord-283382-t890r7xp	287	29	[	[	-LRB-
cord-283382-t890r7xp	287	30	(	(	-LRB-
cord-283382-t890r7xp	287	31	5	5	CD
cord-283382-t890r7xp	287	32	,	,	,
cord-283382-t890r7xp	287	33	168	168	CD
cord-283382-t890r7xp	287	34	)	)	-RRB-
cord-283382-t890r7xp	287	35	;	;	:
cord-283382-t890r7xp	287	36	Table	table	NN
cord-283382-t890r7xp	287	37	2	2	CD
cord-283382-t890r7xp	287	38	]	]	-RRB-
cord-283382-t890r7xp	287	39	.	.	.
cord-283382-t890r7xp	288	1	In	in	IN
cord-283382-t890r7xp	288	2	particular	particular	JJ
cord-283382-t890r7xp	288	3	,	,	,
cord-283382-t890r7xp	288	4	HAdV	HAdV	NNP
cord-283382-t890r7xp	288	5	-	-	HYPH
cord-283382-t890r7xp	288	6	C6	C6	NNP
cord-283382-t890r7xp	288	7	and	and	CC
cord-283382-t890r7xp	288	8	ChAdV-3	ChAdV-3	NNP
cord-283382-t890r7xp	288	9	appear	appear	VB
cord-283382-t890r7xp	288	10	to	to	TO
cord-283382-t890r7xp	288	11	possess	possess	VB
cord-283382-t890r7xp	288	12	attributes	attribute	NNS
cord-283382-t890r7xp	288	13	which	which	WDT
cord-283382-t890r7xp	288	14	make	make	VBP
cord-283382-t890r7xp	288	15	them	-PRON-	PRP
cord-283382-t890r7xp	288	16	an	an	DT
cord-283382-t890r7xp	288	17	attractive	attractive	JJ
cord-283382-t890r7xp	288	18	platform	platform	NN
cord-283382-t890r7xp	288	19	vector	vector	NN
cord-283382-t890r7xp	288	20	(	(	-LRB-
cord-283382-t890r7xp	288	21	22	22	CD
cord-283382-t890r7xp	288	22	%	%	NN
cord-283382-t890r7xp	288	23	,	,	,
cord-283382-t890r7xp	288	24	12	12	CD
cord-283382-t890r7xp	288	25	%	%	NN
cord-283382-t890r7xp	288	26	seroprevalence	seroprevalence	NN
cord-283382-t890r7xp	288	27	,	,	,
cord-283382-t890r7xp	288	28	respectively	respectively	RB
cord-283382-t890r7xp	288	29	)	)	-RRB-
cord-283382-t890r7xp	288	30	(	(	-LRB-
cord-283382-t890r7xp	288	31	2	2	CD
cord-283382-t890r7xp	288	32	,	,	,
cord-283382-t890r7xp	288	33	5	5	CD
cord-283382-t890r7xp	288	34	)	)	-RRB-
cord-283382-t890r7xp	288	35	,	,	,
cord-283382-t890r7xp	288	36	and	and	CC
cord-283382-t890r7xp	288	37	as	as	IN
cord-283382-t890r7xp	288	38	a	a	DT
cord-283382-t890r7xp	288	39	result	result	NN
cord-283382-t890r7xp	288	40	,	,	,
cord-283382-t890r7xp	288	41	have	have	VBP
cord-283382-t890r7xp	288	42	been	be	VBN
cord-283382-t890r7xp	288	43	developed	develop	VBN
cord-283382-t890r7xp	288	44	for	for	IN
cord-283382-t890r7xp	288	45	clinical	clinical	JJ
cord-283382-t890r7xp	288	46	testing	testing	NN
cord-283382-t890r7xp	288	47	as	as	IN
cord-283382-t890r7xp	288	48	vaccines	vaccine	NNS
cord-283382-t890r7xp	288	49	against	against	IN
cord-283382-t890r7xp	288	50	major	major	JJ
cord-283382-t890r7xp	288	51	global	global	JJ
cord-283382-t890r7xp	288	52	pathogens	pathogen	NNS
cord-283382-t890r7xp	288	53	,	,	,
cord-283382-t890r7xp	288	54	hepatitis	hepatitis	NN
cord-283382-t890r7xp	288	55	C	C	NNP
cord-283382-t890r7xp	288	56	virus	virus	NN
cord-283382-t890r7xp	288	57	(	(	-LRB-
cord-283382-t890r7xp	288	58	HCV	HCV	NNP
cord-283382-t890r7xp	288	59	)	)	-RRB-
cord-283382-t890r7xp	288	60	(	(	-LRB-
cord-283382-t890r7xp	288	61	2	2	LS
cord-283382-t890r7xp	288	62	)	)	-RRB-
cord-283382-t890r7xp	288	63	and	and	CC
cord-283382-t890r7xp	288	64	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	288	65	(	(	-LRB-
cord-283382-t890r7xp	288	66	169	169	CD
cord-283382-t890r7xp	288	67	)	)	-RRB-
cord-283382-t890r7xp	288	68	.	.	.
cord-283382-t890r7xp	289	1	Both	both	DT
cord-283382-t890r7xp	289	2	HAdV	HAdV	NNP
cord-283382-t890r7xp	289	3	-	-	HYPH
cord-283382-t890r7xp	289	4	C6	C6	NNP
cord-283382-t890r7xp	289	5	and	and	CC
cord-283382-t890r7xp	289	6	ChAdV-3	ChAdV-3	NNP
cord-283382-t890r7xp	289	7	were	be	VBD
cord-283382-t890r7xp	289	8	shown	show	VBN
cord-283382-t890r7xp	289	9	to	to	TO
cord-283382-t890r7xp	289	10	be	be	VB
cord-283382-t890r7xp	289	11	safe	safe	JJ
cord-283382-t890r7xp	289	12	and	and	CC
cord-283382-t890r7xp	289	13	immunogenic	immunogenic	JJ
cord-283382-t890r7xp	289	14	in	in	IN
cord-283382-t890r7xp	289	15	humans	human	NNS
cord-283382-t890r7xp	289	16	when	when	WRB
cord-283382-t890r7xp	289	17	used	use	VBN
cord-283382-t890r7xp	289	18	as	as	IN
cord-283382-t890r7xp	289	19	a	a	DT
cord-283382-t890r7xp	289	20	vaccine	vaccine	NN
cord-283382-t890r7xp	289	21	to	to	TO
cord-283382-t890r7xp	289	22	elicit	elicit	VB
cord-283382-t890r7xp	289	23	immunity	immunity	NN
cord-283382-t890r7xp	289	24	against	against	IN
cord-283382-t890r7xp	289	25	HCV	HCV	NNP
cord-283382-t890r7xp	289	26	,	,	,
cord-283382-t890r7xp	289	27	although	although	IN
cord-283382-t890r7xp	289	28	HAdV	HAdV	NNP
cord-283382-t890r7xp	289	29	-	-	HYPH
cord-283382-t890r7xp	289	30	C6	C6	NNP
cord-283382-t890r7xp	289	31	appeared	appear	VBD
cord-283382-t890r7xp	289	32	to	to	TO
cord-283382-t890r7xp	289	33	be	be	VB
cord-283382-t890r7xp	289	34	superior	superior	JJ
cord-283382-t890r7xp	289	35	in	in	IN
cord-283382-t890r7xp	289	36	its	-PRON-	PRP$
cord-283382-t890r7xp	289	37	ability	ability	NN
cord-283382-t890r7xp	289	38	to	to	TO
cord-283382-t890r7xp	289	39	cellular	cellular	JJ
cord-283382-t890r7xp	289	40	immune	immune	JJ
cord-283382-t890r7xp	289	41	responses	response	NNS
cord-283382-t890r7xp	289	42	with	with	IN
cord-283382-t890r7xp	289	43	increased	increase	VBN
cord-283382-t890r7xp	289	44	magnitude	magnitude	NN
cord-283382-t890r7xp	289	45	and	and	CC
cord-283382-t890r7xp	289	46	breadth	breadth	NN
cord-283382-t890r7xp	289	47	at	at	IN
cord-283382-t890r7xp	289	48	lower	low	JJR
cord-283382-t890r7xp	289	49	doses	dose	NNS
cord-283382-t890r7xp	289	50	(	(	-LRB-
cord-283382-t890r7xp	289	51	i.e.	i.e.	FW
cord-283382-t890r7xp	289	52	,	,	,
cord-283382-t890r7xp	289	53	5	5	CD
cord-283382-t890r7xp	289	54	×	×	CD
cord-283382-t890r7xp	289	55	10	10	CD
cord-283382-t890r7xp	289	56	8	8	CD
cord-283382-t890r7xp	289	57	vp	vp	NNP
cord-283382-t890r7xp	289	58	)	)	-RRB-
cord-283382-t890r7xp	289	59	(	(	-LRB-
cord-283382-t890r7xp	289	60	2	2	CD
cord-283382-t890r7xp	289	61	)	)	-RRB-
cord-283382-t890r7xp	289	62	.	.	.
cord-283382-t890r7xp	290	1	With	with	IN
cord-283382-t890r7xp	290	2	regard	regard	NN
cord-283382-t890r7xp	290	3	to	to	IN
cord-283382-t890r7xp	290	4	ChAdV-3	chadv-3	NN
cord-283382-t890r7xp	290	5	,	,	,
cord-283382-t890r7xp	290	6	part	part	NN
cord-283382-t890r7xp	290	7	of	of	IN
cord-283382-t890r7xp	290	8	its	-PRON-	PRP$
cord-283382-t890r7xp	290	9	appeal	appeal	NN
cord-283382-t890r7xp	290	10	includes	include	VBZ
cord-283382-t890r7xp	290	11	its	-PRON-	PRP$
cord-283382-t890r7xp	290	12	ability	ability	NN
cord-283382-t890r7xp	290	13	to	to	TO
cord-283382-t890r7xp	290	14	elicit	elicit	VB
cord-283382-t890r7xp	290	15	long	long	RB
cord-283382-t890r7xp	290	16	-	-	HYPH
cord-283382-t890r7xp	290	17	lived	live	VBN
cord-283382-t890r7xp	290	18	cellular	cellular	JJ
cord-283382-t890r7xp	290	19	and	and	CC
cord-283382-t890r7xp	290	20	humoral	humoral	JJ
cord-283382-t890r7xp	290	21	immune	immune	JJ
cord-283382-t890r7xp	290	22	responses	response	NNS
cord-283382-t890r7xp	290	23	directed	direct	VBN
cord-283382-t890r7xp	290	24	toward	toward	IN
cord-283382-t890r7xp	290	25	the	the	DT
cord-283382-t890r7xp	290	26	encoded	encoded	JJ
cord-283382-t890r7xp	290	27	vaccine	vaccine	NN
cord-283382-t890r7xp	290	28	antigen	antigen	NN
cord-283382-t890r7xp	290	29	.	.	.
cord-283382-t890r7xp	291	1	Immunization	immunization	NN
cord-283382-t890r7xp	291	2	of	of	IN
cord-283382-t890r7xp	291	3	NHPs	nhp	NNS
cord-283382-t890r7xp	291	4	with	with	IN
cord-283382-t890r7xp	291	5	ChAdV-3	ChAdV-3	NNP
cord-283382-t890r7xp	291	6	expressing	express	VBG
cord-283382-t890r7xp	291	7	HIV	HIV	NNP
cord-283382-t890r7xp	291	8	gag	gag	NN
cord-283382-t890r7xp	291	9	resulted	result	VBN
cord-283382-t890r7xp	291	10	in	in	IN
cord-283382-t890r7xp	291	11	cellular	cellular	JJ
cord-283382-t890r7xp	291	12	immune	immune	JJ
cord-283382-t890r7xp	291	13	responses	response	NNS
cord-283382-t890r7xp	291	14	which	which	WDT
cord-283382-t890r7xp	291	15	persisted	persist	VBD
cord-283382-t890r7xp	291	16	for	for	IN
cord-283382-t890r7xp	291	17	more	more	JJR
cord-283382-t890r7xp	291	18	than	than	IN
cord-283382-t890r7xp	291	19	5	5	CD
cord-283382-t890r7xp	291	20	years	year	NNS
cord-283382-t890r7xp	291	21	(	(	-LRB-
cord-283382-t890r7xp	291	22	5	5	CD
cord-283382-t890r7xp	291	23	)	)	-RRB-
cord-283382-t890r7xp	291	24	.	.	.
cord-283382-t890r7xp	292	1	A	a	DT
cord-283382-t890r7xp	292	2	heterologous	heterologous	JJ
cord-283382-t890r7xp	292	3	boost	boost	NN
cord-283382-t890r7xp	292	4	with	with	IN
cord-283382-t890r7xp	292	5	PanAdV-3	PanAdV-3	NNP
cord-283382-t890r7xp	292	6	at	at	IN
cord-283382-t890r7xp	292	7	week	week	NN
cord-283382-t890r7xp	292	8	299	299	CD
cord-283382-t890r7xp	292	9	facilitated	facilitate	VBD
cord-283382-t890r7xp	292	10	an	an	DT
cord-283382-t890r7xp	292	11	expansion	expansion	NN
cord-283382-t890r7xp	292	12	of	of	IN
cord-283382-t890r7xp	292	13	gag	gag	NN
cord-283382-t890r7xp	292	14	-	-	HYPH
cord-283382-t890r7xp	292	15	specific	specific	JJ
cord-283382-t890r7xp	292	16	IFN	IFN	NNP
cord-283382-t890r7xp	292	17	-	-	HYPH
cord-283382-t890r7xp	292	18	γ	γ	NN
cord-283382-t890r7xp	292	19	secreting	secrete	VBG
cord-283382-t890r7xp	292	20	T	t	NN
cord-283382-t890r7xp	292	21	cells	cell	NNS
cord-283382-t890r7xp	292	22	,	,	,
cord-283382-t890r7xp	292	23	in	in	IN
cord-283382-t890r7xp	292	24	addition	addition	NN
cord-283382-t890r7xp	292	25	to	to	IN
cord-283382-t890r7xp	292	26	boosting	boost	VBG
cord-283382-t890r7xp	292	27	antibodies	antibody	NNS
cord-283382-t890r7xp	292	28	to	to	IN
cord-283382-t890r7xp	292	29	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	292	30	gag	gag	NN
cord-283382-t890r7xp	292	31	.	.	.
cord-283382-t890r7xp	293	1	As	as	IN
cord-283382-t890r7xp	293	2	such	such	JJ
cord-283382-t890r7xp	293	3	,	,	,
cord-283382-t890r7xp	293	4	there	there	EX
cord-283382-t890r7xp	293	5	is	be	VBZ
cord-283382-t890r7xp	293	6	broad	broad	JJ
cord-283382-t890r7xp	293	7	interest	interest	NN
cord-283382-t890r7xp	293	8	in	in	IN
cord-283382-t890r7xp	293	9	using	use	VBG
cord-283382-t890r7xp	293	10	these	these	DT
cord-283382-t890r7xp	293	11	rare	rare	JJ
cord-283382-t890r7xp	293	12	vectors	vector	NNS
cord-283382-t890r7xp	293	13	in	in	IN
cord-283382-t890r7xp	293	14	heterologous	heterologous	JJ
cord-283382-t890r7xp	293	15	prime	prime	NN
cord-283382-t890r7xp	293	16	:	:	:
cord-283382-t890r7xp	293	17	boost	boost	VB
cord-283382-t890r7xp	293	18	vaccination	vaccination	NN
cord-283382-t890r7xp	293	19	regimens	regimen	NNS
cord-283382-t890r7xp	293	20	in	in	IN
cord-283382-t890r7xp	293	21	an	an	DT
cord-283382-t890r7xp	293	22	effort	effort	NN
cord-283382-t890r7xp	293	23	to	to	TO
cord-283382-t890r7xp	293	24	confer	confer	VB
cord-283382-t890r7xp	293	25	long	long	RB
cord-283382-t890r7xp	293	26	-	-	HYPH
cord-283382-t890r7xp	293	27	lived	live	VBN
cord-283382-t890r7xp	293	28	protective	protective	JJ
cord-283382-t890r7xp	293	29	immunity	immunity	NN
cord-283382-t890r7xp	293	30	against	against	IN
cord-283382-t890r7xp	293	31	challenging	challenging	JJ
cord-283382-t890r7xp	293	32	pathogens	pathogen	NNS
cord-283382-t890r7xp	293	33	.	.	.
cord-283382-t890r7xp	294	1	In	in	IN
cord-283382-t890r7xp	294	2	support	support	NN
cord-283382-t890r7xp	294	3	of	of	IN
cord-283382-t890r7xp	294	4	this	this	DT
cord-283382-t890r7xp	294	5	,	,	,
cord-283382-t890r7xp	294	6	a	a	DT
cord-283382-t890r7xp	294	7	Phase	phase	NN
cord-283382-t890r7xp	294	8	I	-PRON-	PRP
cord-283382-t890r7xp	294	9	clinical	clinical	JJ
cord-283382-t890r7xp	294	10	trial	trial	NN
cord-283382-t890r7xp	294	11	to	to	TO
cord-283382-t890r7xp	294	12	test	test	VB
cord-283382-t890r7xp	294	13	the	the	DT
cord-283382-t890r7xp	294	14	HAdV	HAdV	NNP
cord-283382-t890r7xp	294	15	-	-	HYPH
cord-283382-t890r7xp	294	16	C6	C6	NNP
cord-283382-t890r7xp	294	17	and	and	CC
cord-283382-t890r7xp	294	18	ChAdV-3	ChAdV-3	NNP
cord-283382-t890r7xp	294	19	vectors	vector	NNS
cord-283382-t890r7xp	294	20	expressing	express	VBG
cord-283382-t890r7xp	294	21	HCV	HCV	NNP
cord-283382-t890r7xp	294	22	antigens	antigen	NNS
cord-283382-t890r7xp	294	23	demonstrated	demonstrate	VBD
cord-283382-t890r7xp	294	24	that	that	IN
cord-283382-t890r7xp	294	25	heterologous	heterologous	JJ
cord-283382-t890r7xp	294	26	boost	boost	NN
cord-283382-t890r7xp	294	27	immunizations	immunization	NNS
cord-283382-t890r7xp	294	28	resulted	result	VBD
cord-283382-t890r7xp	294	29	in	in	IN
cord-283382-t890r7xp	294	30	long	long	RB
cord-283382-t890r7xp	294	31	-	-	HYPH
cord-283382-t890r7xp	294	32	lived	live	VBN
cord-283382-t890r7xp	294	33	,	,	,
cord-283382-t890r7xp	294	34	polyfunctional	polyfunctional	JJ
cord-283382-t890r7xp	294	35	effector	effector	NNP
cord-283382-t890r7xp	294	36	,	,	,
cord-283382-t890r7xp	294	37	and	and	CC
cord-283382-t890r7xp	294	38	central	central	JJ
cord-283382-t890r7xp	294	39	memory	memory	NN
cord-283382-t890r7xp	294	40	T	T	NNP
cord-283382-t890r7xp	294	41	cell	cell	NN
cord-283382-t890r7xp	294	42	responses	response	NNS
cord-283382-t890r7xp	294	43	which	which	WDT
cord-283382-t890r7xp	294	44	were	be	VBD
cord-283382-t890r7xp	294	45	sustained	sustain	VBN
cord-283382-t890r7xp	294	46	for	for	IN
cord-283382-t890r7xp	294	47	up	up	IN
cord-283382-t890r7xp	294	48	to	to	TO
cord-283382-t890r7xp	294	49	1	1	CD
cord-283382-t890r7xp	294	50	year	year	NN
cord-283382-t890r7xp	294	51	in	in	IN
cord-283382-t890r7xp	294	52	humans	human	NNS
cord-283382-t890r7xp	294	53	(	(	-LRB-
cord-283382-t890r7xp	294	54	2	2	CD
cord-283382-t890r7xp	294	55	)	)	-RRB-
cord-283382-t890r7xp	294	56	.	.	.
cord-283382-t890r7xp	295	1	PanAdV-3	panadv-3	NN
cord-283382-t890r7xp	295	2	expressing	express	VBG
cord-283382-t890r7xp	295	3	Respiratory	respiratory	JJ
cord-283382-t890r7xp	295	4	Syncytial	Syncytial	NNP
cord-283382-t890r7xp	295	5	Virus	virus	NN
cord-283382-t890r7xp	295	6	(	(	-LRB-
cord-283382-t890r7xp	295	7	RSV	RSV	NNP
cord-283382-t890r7xp	295	8	)	)	-RRB-
cord-283382-t890r7xp	295	9	fusion	fusion	NN
cord-283382-t890r7xp	295	10	(	(	-LRB-
cord-283382-t890r7xp	295	11	F	F	NNP
cord-283382-t890r7xp	295	12	)	)	-RRB-
cord-283382-t890r7xp	295	13	,	,	,
cord-283382-t890r7xp	295	14	nucleocapsid	nucleocapsid	NN
cord-283382-t890r7xp	295	15	(	(	-LRB-
cord-283382-t890r7xp	295	16	N	N	NNP
cord-283382-t890r7xp	295	17	)	)	-RRB-
cord-283382-t890r7xp	295	18	,	,	,
cord-283382-t890r7xp	295	19	and	and	CC
cord-283382-t890r7xp	295	20	matrix	matrix	NNP
cord-283382-t890r7xp	295	21	(	(	-LRB-
cord-283382-t890r7xp	295	22	M2	M2	NNP
cord-283382-t890r7xp	295	23	-	-	HYPH
cord-283382-t890r7xp	295	24	1	1	CD
cord-283382-t890r7xp	295	25	)	)	-RRB-
cord-283382-t890r7xp	295	26	antigens	antigen	NNS
cord-283382-t890r7xp	295	27	has	have	VBZ
cord-283382-t890r7xp	295	28	also	also	RB
cord-283382-t890r7xp	295	29	been	be	VBN
cord-283382-t890r7xp	295	30	tested	test	VBN
cord-283382-t890r7xp	295	31	in	in	IN
cord-283382-t890r7xp	295	32	humans	human	NNS
cord-283382-t890r7xp	295	33	following	follow	VBG
cord-283382-t890r7xp	295	34	i.n	i.n	NNP
cord-283382-t890r7xp	295	35	.	.	.
cord-283382-t890r7xp	296	1	and	and	CC
cord-283382-t890r7xp	296	2	i.m	i.m	NNP
cord-283382-t890r7xp	296	3	.	.	NNP
cord-283382-t890r7xp	296	4	administration	administration	NNP
cord-283382-t890r7xp	296	5	(	(	-LRB-
cord-283382-t890r7xp	296	6	37	37	CD
cord-283382-t890r7xp	296	7	)	)	-RRB-
cord-283382-t890r7xp	296	8	.	.	.
cord-283382-t890r7xp	297	1	Neutralizing	neutralize	VBG
cord-283382-t890r7xp	297	2	antibodies	antibody	NNS
cord-283382-t890r7xp	297	3	to	to	IN
cord-283382-t890r7xp	297	4	RSV	RSV	NNP
cord-283382-t890r7xp	297	5	F	F	NNP
cord-283382-t890r7xp	297	6	were	be	VBD
cord-283382-t890r7xp	297	7	increased	increase	VBN
cord-283382-t890r7xp	297	8	following	follow	VBG
cord-283382-t890r7xp	297	9	i.m	i.m	NNP
cord-283382-t890r7xp	297	10	.	.	NNP
cord-283382-t890r7xp	297	11	,	,	,
cord-283382-t890r7xp	297	12	but	but	CC
cord-283382-t890r7xp	297	13	not	not	RB
cord-283382-t890r7xp	297	14	i.n	i.n	NNP
cord-283382-t890r7xp	297	15	.	.	NNP
cord-283382-t890r7xp	297	16	prime	prime	JJ
cord-283382-t890r7xp	297	17	immunization	immunization	NN
cord-283382-t890r7xp	297	18	.	.	.
cord-283382-t890r7xp	298	1	Similar	similar	JJ
cord-283382-t890r7xp	298	2	trends	trend	NNS
cord-283382-t890r7xp	298	3	were	be	VBD
cord-283382-t890r7xp	298	4	observed	observe	VBN
cord-283382-t890r7xp	298	5	for	for	IN
cord-283382-t890r7xp	298	6	antigen	antigen	NN
cord-283382-t890r7xp	298	7	-	-	HYPH
cord-283382-t890r7xp	298	8	specific	specific	JJ
cord-283382-t890r7xp	298	9	T	t	NN
cord-283382-t890r7xp	298	10	cell	cell	NN
cord-283382-t890r7xp	298	11	responses	response	NNS
cord-283382-t890r7xp	298	12	to	to	IN
cord-283382-t890r7xp	298	13	the	the	DT
cord-283382-t890r7xp	298	14	vaccine	vaccine	NN
cord-283382-t890r7xp	298	15	inserts	insert	NNS
cord-283382-t890r7xp	298	16	,	,	,
cord-283382-t890r7xp	298	17	although	although	IN
cord-283382-t890r7xp	298	18	increases	increase	NNS
cord-283382-t890r7xp	298	19	were	be	VBD
cord-283382-t890r7xp	298	20	minimal	minimal	JJ
cord-283382-t890r7xp	298	21	following	follow	VBG
cord-283382-t890r7xp	298	22	PanAdV-3	PanAdV-3	NNP
cord-283382-t890r7xp	298	23	i.m	i.m	NNP
cord-283382-t890r7xp	298	24	.	.	NNP
cord-283382-t890r7xp	298	25	prime	prime	NNP
cord-283382-t890r7xp	298	26	only	only	RB
cord-283382-t890r7xp	298	27	.	.	.
cord-283382-t890r7xp	299	1	This	this	DT
cord-283382-t890r7xp	299	2	vaccine	vaccine	NN
cord-283382-t890r7xp	299	3	was	be	VBD
cord-283382-t890r7xp	299	4	also	also	RB
cord-283382-t890r7xp	299	5	evaluated	evaluate	VBN
cord-283382-t890r7xp	299	6	in	in	IN
cord-283382-t890r7xp	299	7	older	old	JJR
cord-283382-t890r7xp	299	8	adults	adult	NNS
cord-283382-t890r7xp	299	9	(	(	-LRB-
cord-283382-t890r7xp	299	10	60	60	CD
cord-283382-t890r7xp	299	11	-	-	SYM
cord-283382-t890r7xp	299	12	75	75	CD
cord-283382-t890r7xp	299	13	years	year	NNS
cord-283382-t890r7xp	299	14	)	)	-RRB-
cord-283382-t890r7xp	299	15	who	who	WP
cord-283382-t890r7xp	299	16	are	be	VBP
cord-283382-t890r7xp	299	17	at	at	IN
cord-283382-t890r7xp	299	18	increased	increase	VBN
cord-283382-t890r7xp	299	19	risk	risk	NN
cord-283382-t890r7xp	299	20	of	of	IN
cord-283382-t890r7xp	299	21	severe	severe	JJ
cord-283382-t890r7xp	299	22	RSV	RSV	NNP
cord-283382-t890r7xp	299	23	disease	disease	NN
cord-283382-t890r7xp	299	24	,	,	,
cord-283382-t890r7xp	299	25	with	with	IN
cord-283382-t890r7xp	299	26	similar	similar	JJ
cord-283382-t890r7xp	299	27	results	result	NNS
cord-283382-t890r7xp	299	28	(	(	-LRB-
cord-283382-t890r7xp	299	29	170	170	CD
cord-283382-t890r7xp	299	30	)	)	-RRB-
cord-283382-t890r7xp	299	31	.	.	.
cord-283382-t890r7xp	300	1	Immune	immune	JJ
cord-283382-t890r7xp	300	2	responses	response	NNS
cord-283382-t890r7xp	300	3	elicited	elicit	VBN
cord-283382-t890r7xp	300	4	by	by	IN
cord-283382-t890r7xp	300	5	PanAdV-3	PanAdV-3	NNP
cord-283382-t890r7xp	300	6	were	be	VBD
cord-283382-t890r7xp	300	7	improved	improve	VBN
cord-283382-t890r7xp	300	8	upon	upon	IN
cord-283382-t890r7xp	300	9	boosting	boost	VBG
cord-283382-t890r7xp	300	10	with	with	IN
cord-283382-t890r7xp	300	11	an	an	DT
cord-283382-t890r7xp	300	12	MVA	MVA	NNP
cord-283382-t890r7xp	300	13	vector	vector	NN
cord-283382-t890r7xp	300	14	which	which	WDT
cord-283382-t890r7xp	300	15	also	also	RB
cord-283382-t890r7xp	300	16	encoded	encode	VBD
cord-283382-t890r7xp	300	17	the	the	DT
cord-283382-t890r7xp	300	18	RSV	RSV	NNP
cord-283382-t890r7xp	300	19	transgene	transgene	NN
cord-283382-t890r7xp	300	20	antigen	antigen	NN
cord-283382-t890r7xp	300	21	.	.	.
cord-283382-t890r7xp	301	1	ChAdV-63	ChAdV-63	NNP
cord-283382-t890r7xp	301	2	,	,	,
cord-283382-t890r7xp	301	3	also	also	RB
cord-283382-t890r7xp	301	4	identified	identify	VBD
cord-283382-t890r7xp	301	5	as	as	IN
cord-283382-t890r7xp	301	6	a	a	DT
cord-283382-t890r7xp	301	7	clinically	clinically	RB
cord-283382-t890r7xp	301	8	viable	viable	JJ
cord-283382-t890r7xp	301	9	Ad	ad	NN
cord-283382-t890r7xp	301	10	vector	vector	NN
cord-283382-t890r7xp	301	11	with	with	IN
cord-283382-t890r7xp	301	12	low	low	JJ
cord-283382-t890r7xp	301	13	seroprevalence	seroprevalence	NN
cord-283382-t890r7xp	301	14	which	which	WDT
cord-283382-t890r7xp	301	15	displayed	display	VBD
cord-283382-t890r7xp	301	16	protective	protective	JJ
cord-283382-t890r7xp	301	17	efficacy	efficacy	NN
cord-283382-t890r7xp	301	18	in	in	IN
cord-283382-t890r7xp	301	19	animal	animal	NN
cord-283382-t890r7xp	301	20	studies	study	NNS
cord-283382-t890r7xp	301	21	(	(	-LRB-
cord-283382-t890r7xp	301	22	Table	Table	NNP
cord-283382-t890r7xp	301	23	2	2	CD
cord-283382-t890r7xp	301	24	)	)	-RRB-
cord-283382-t890r7xp	301	25	,	,	,
cord-283382-t890r7xp	301	26	has	have	VBZ
cord-283382-t890r7xp	301	27	been	be	VBN
cord-283382-t890r7xp	301	28	shown	show	VBN
cord-283382-t890r7xp	301	29	to	to	TO
cord-283382-t890r7xp	301	30	be	be	VB
cord-283382-t890r7xp	301	31	safe	safe	JJ
cord-283382-t890r7xp	301	32	and	and	CC
cord-283382-t890r7xp	301	33	immunogenic	immunogenic	JJ
cord-283382-t890r7xp	301	34	in	in	IN
cord-283382-t890r7xp	301	35	children	child	NNS
cord-283382-t890r7xp	301	36	and	and	CC
cord-283382-t890r7xp	301	37	adults	adult	NNS
cord-283382-t890r7xp	301	38	(	(	-LRB-
cord-283382-t890r7xp	301	39	171	171	CD
cord-283382-t890r7xp	301	40	)	)	-RRB-
cord-283382-t890r7xp	301	41	(	(	-LRB-
cord-283382-t890r7xp	301	42	172	172	CD
cord-283382-t890r7xp	301	43	)	)	-RRB-
cord-283382-t890r7xp	301	44	(	(	-LRB-
cord-283382-t890r7xp	301	45	173	173	CD
cord-283382-t890r7xp	301	46	)	)	-RRB-
cord-283382-t890r7xp	301	47	(	(	-LRB-
cord-283382-t890r7xp	301	48	174	174	CD
cord-283382-t890r7xp	301	49	)	)	-RRB-
cord-283382-t890r7xp	301	50	.	.	.
cord-283382-t890r7xp	302	1	When	when	WRB
cord-283382-t890r7xp	302	2	ChAdV-63	ChAdV-63	NNP
cord-283382-t890r7xp	302	3	has	have	VBZ
cord-283382-t890r7xp	302	4	been	be	VBN
cord-283382-t890r7xp	302	5	used	use	VBN
cord-283382-t890r7xp	302	6	in	in	IN
cord-283382-t890r7xp	302	7	a	a	DT
cord-283382-t890r7xp	302	8	prime	prime	NN
cord-283382-t890r7xp	302	9	:	:	:
cord-283382-t890r7xp	302	10	boost	boost	NN
cord-283382-t890r7xp	302	11	vaccination	vaccination	NN
cord-283382-t890r7xp	302	12	regimen	regimen	NN
cord-283382-t890r7xp	302	13	with	with	IN
cord-283382-t890r7xp	302	14	MVA	MVA	NNP
cord-283382-t890r7xp	302	15	expressing	express	VBG
cord-283382-t890r7xp	302	16	malaria	malaria	NN
cord-283382-t890r7xp	302	17	antigens	antigen	NNS
cord-283382-t890r7xp	302	18	,	,	,
cord-283382-t890r7xp	302	19	promising	promising	JJ
cord-283382-t890r7xp	302	20	efficacy	efficacy	NN
cord-283382-t890r7xp	302	21	was	be	VBD
cord-283382-t890r7xp	302	22	observed	observe	VBN
cord-283382-t890r7xp	302	23	in	in	IN
cord-283382-t890r7xp	302	24	UK	UK	NNP
cord-283382-t890r7xp	302	25	and	and	CC
cord-283382-t890r7xp	302	26	Kenyan	kenyan	JJ
cord-283382-t890r7xp	302	27	adults	adult	NNS
cord-283382-t890r7xp	302	28	(	(	-LRB-
cord-283382-t890r7xp	302	29	175	175	CD
cord-283382-t890r7xp	302	30	,	,	,
cord-283382-t890r7xp	302	31	176	176	CD
cord-283382-t890r7xp	302	32	)	)	-RRB-
cord-283382-t890r7xp	302	33	,	,	,
cord-283382-t890r7xp	302	34	but	but	CC
cord-283382-t890r7xp	302	35	has	have	VBZ
cord-283382-t890r7xp	302	36	recently	recently	RB
cord-283382-t890r7xp	302	37	been	be	VBN
cord-283382-t890r7xp	302	38	associated	associate	VBN
cord-283382-t890r7xp	302	39	with	with	IN
cord-283382-t890r7xp	302	40	disappointing	disappointing	JJ
cord-283382-t890r7xp	302	41	efficacy	efficacy	NN
cord-283382-t890r7xp	302	42	in	in	IN
cord-283382-t890r7xp	302	43	field	field	NN
cord-283382-t890r7xp	302	44	trials	trial	NNS
cord-283382-t890r7xp	302	45	in	in	IN
cord-283382-t890r7xp	302	46	young	young	JJ
cord-283382-t890r7xp	302	47	children	child	NNS
cord-283382-t890r7xp	302	48	in	in	IN
cord-283382-t890r7xp	302	49	Burkina	Burkina	NNP
cord-283382-t890r7xp	302	50	Faso	Faso	NNP
cord-283382-t890r7xp	302	51	,	,	,
cord-283382-t890r7xp	302	52	a	a	DT
cord-283382-t890r7xp	302	53	highly	highly	RB
cord-283382-t890r7xp	302	54	endemic	endemic	JJ
cord-283382-t890r7xp	302	55	malaria	malaria	NN
cord-283382-t890r7xp	302	56	transmission	transmission	NN
cord-283382-t890r7xp	302	57	region	region	NN
cord-283382-t890r7xp	302	58	(	(	-LRB-
cord-283382-t890r7xp	302	59	177	177	CD
cord-283382-t890r7xp	302	60	)	)	-RRB-
cord-283382-t890r7xp	302	61	.	.	.
cord-283382-t890r7xp	303	1	ChAdOx-1	ChAdOx-1	NNP
cord-283382-t890r7xp	303	2	is	be	VBZ
cord-283382-t890r7xp	303	3	a	a	DT
cord-283382-t890r7xp	303	4	species	species	NN
cord-283382-t890r7xp	303	5	E	e	NN
cord-283382-t890r7xp	303	6	chimpanzee	chimpanzee	NN
cord-283382-t890r7xp	303	7	Ad	ad	NN
cord-283382-t890r7xp	303	8	vector	vector	NN
cord-283382-t890r7xp	303	9	developed	develop	VBN
cord-283382-t890r7xp	303	10	by	by	IN
cord-283382-t890r7xp	303	11	the	the	DT
cord-283382-t890r7xp	303	12	Jenner	Jenner	NNP
cord-283382-t890r7xp	303	13	Institute	Institute	NNP
cord-283382-t890r7xp	303	14	at	at	IN
cord-283382-t890r7xp	303	15	University	University	NNP
cord-283382-t890r7xp	303	16	of	of	IN
cord-283382-t890r7xp	303	17	Oxford	Oxford	NNP
cord-283382-t890r7xp	303	18	which	which	WDT
cord-283382-t890r7xp	303	19	has	have	VBZ
cord-283382-t890r7xp	303	20	been	be	VBN
cord-283382-t890r7xp	303	21	tested	test	VBN
cord-283382-t890r7xp	303	22	clinically	clinically	RB
cord-283382-t890r7xp	303	23	as	as	IN
cord-283382-t890r7xp	303	24	a	a	DT
cord-283382-t890r7xp	303	25	vaccine	vaccine	NN
cord-283382-t890r7xp	303	26	for	for	IN
cord-283382-t890r7xp	303	27	influenza	influenza	NN
cord-283382-t890r7xp	303	28	virus	virus	NN
cord-283382-t890r7xp	303	29	as	as	IN
cord-283382-t890r7xp	303	30	a	a	DT
cord-283382-t890r7xp	303	31	standalone	standalone	JJ
cord-283382-t890r7xp	303	32	vector	vector	NN
cord-283382-t890r7xp	303	33	or	or	CC
cord-283382-t890r7xp	303	34	for	for	IN
cord-283382-t890r7xp	303	35	use	use	NN
cord-283382-t890r7xp	303	36	in	in	IN
cord-283382-t890r7xp	303	37	prime	prime	NN
cord-283382-t890r7xp	303	38	:	:	:
cord-283382-t890r7xp	303	39	boost	boost	NN
cord-283382-t890r7xp	303	40	with	with	IN
cord-283382-t890r7xp	303	41	MVA	MVA	NNP
cord-283382-t890r7xp	303	42	(	(	-LRB-
cord-283382-t890r7xp	303	43	1	1	CD
cord-283382-t890r7xp	303	44	,	,	,
cord-283382-t890r7xp	303	45	3	3	CD
cord-283382-t890r7xp	303	46	)	)	-RRB-
cord-283382-t890r7xp	303	47	,	,	,
cord-283382-t890r7xp	303	48	and	and	CC
cord-283382-t890r7xp	303	49	for	for	IN
cord-283382-t890r7xp	303	50	several	several	JJ
cord-283382-t890r7xp	303	51	other	other	JJ
cord-283382-t890r7xp	303	52	infectious	infectious	JJ
cord-283382-t890r7xp	303	53	disease	disease	NN
cord-283382-t890r7xp	303	54	targets	target	NNS
cord-283382-t890r7xp	303	55	such	such	JJ
cord-283382-t890r7xp	303	56	as	as	IN
cord-283382-t890r7xp	303	57	Chikungunya	Chikungunya	NNP
cord-283382-t890r7xp	303	58	Fever	Fever	NNP
cord-283382-t890r7xp	303	59	(	(	-LRB-
cord-283382-t890r7xp	303	60	NCT03590392	nct03590392	CD
cord-283382-t890r7xp	303	61	)	)	-RRB-
cord-283382-t890r7xp	303	62	,	,	,
cord-283382-t890r7xp	303	63	malaria	malaria	FW
cord-283382-t890r7xp	303	64	(	(	-LRB-
cord-283382-t890r7xp	303	65	NCT03203421	NCT03203421	NNP
cord-283382-t890r7xp	303	66	)	)	-RRB-
cord-283382-t890r7xp	303	67	,	,	,
cord-283382-t890r7xp	303	68	and	and	CC
cord-283382-t890r7xp	303	69	tuberculosis	tuberculosis	NN
cord-283382-t890r7xp	303	70	(	(	-LRB-
cord-283382-t890r7xp	303	71	NCT01829490	NCT01829490	NNP
cord-283382-t890r7xp	303	72	)	)	-RRB-
cord-283382-t890r7xp	303	73	.	.	.
cord-283382-t890r7xp	304	1	Numerous	numerous	JJ
cord-283382-t890r7xp	304	2	additional	additional	JJ
cord-283382-t890r7xp	304	3	trials	trial	NNS
cord-283382-t890r7xp	304	4	are	be	VBP
cord-283382-t890r7xp	304	5	currently	currently	RB
cord-283382-t890r7xp	304	6	ongoing	ongoing	JJ
cord-283382-t890r7xp	304	7	or	or	CC
cord-283382-t890r7xp	304	8	actively	actively	RB
cord-283382-t890r7xp	304	9	recruiting	recruit	VBG
cord-283382-t890r7xp	304	10	participants	participant	NNS
cord-283382-t890r7xp	304	11	,	,	,
cord-283382-t890r7xp	304	12	including	include	VBG
cord-283382-t890r7xp	304	13	a	a	DT
cord-283382-t890r7xp	304	14	recently	recently	RB
cord-283382-t890r7xp	304	15	initiated	initiate	VBN
cord-283382-t890r7xp	304	16	study	study	NN
cord-283382-t890r7xp	304	17	to	to	TO
cord-283382-t890r7xp	304	18	test	test	VB
cord-283382-t890r7xp	304	19	a	a	DT
cord-283382-t890r7xp	304	20	novel	novel	JJ
cord-283382-t890r7xp	304	21	vaccine	vaccine	NN
cord-283382-t890r7xp	304	22	for	for	IN
cord-283382-t890r7xp	304	23	COVID-19	COVID-19	NNP
cord-283382-t890r7xp	304	24	(	(	-LRB-
cord-283382-t890r7xp	304	25	NCT04324606	NCT04324606	NNP
cord-283382-t890r7xp	304	26	)	)	-RRB-
cord-283382-t890r7xp	304	27	.	.	.
cord-283382-t890r7xp	305	1	In	in	IN
cord-283382-t890r7xp	305	2	addition	addition	NN
cord-283382-t890r7xp	305	3	to	to	IN
cord-283382-t890r7xp	305	4	vectors	vector	NNS
cord-283382-t890r7xp	305	5	derived	derive	VBN
cord-283382-t890r7xp	305	6	from	from	IN
cord-283382-t890r7xp	305	7	NHPs	nhp	NNS
cord-283382-t890r7xp	305	8	,	,	,
cord-283382-t890r7xp	305	9	promising	promise	VBG
cord-283382-t890r7xp	305	10	advances	advance	NNS
cord-283382-t890r7xp	305	11	have	have	VBP
cord-283382-t890r7xp	305	12	been	be	VBN
cord-283382-t890r7xp	305	13	the	the	DT
cord-283382-t890r7xp	305	14	development	development	NN
cord-283382-t890r7xp	305	15	of	of	IN
cord-283382-t890r7xp	305	16	HAdV	HAdV	NNP
cord-283382-t890r7xp	305	17	-	-	HYPH
cord-283382-t890r7xp	305	18	D26	D26	NNP
cord-283382-t890r7xp	305	19	vectors	vector	NNS
cord-283382-t890r7xp	305	20	.	.	.
cord-283382-t890r7xp	306	1	With	with	IN
cord-283382-t890r7xp	306	2	a	a	DT
cord-283382-t890r7xp	306	3	number	number	NN
cord-283382-t890r7xp	306	4	of	of	IN
cord-283382-t890r7xp	306	5	clinical	clinical	JJ
cord-283382-t890r7xp	306	6	trials	trial	NNS
cord-283382-t890r7xp	306	7	registered	register	VBN
cord-283382-t890r7xp	306	8	on	on	IN
cord-283382-t890r7xp	306	9	ClinicalTrials.gov	ClinicalTrials.gov	NNP
cord-283382-t890r7xp	306	10	,	,	,
cord-283382-t890r7xp	306	11	this	this	DT
cord-283382-t890r7xp	306	12	platform	platform	NN
cord-283382-t890r7xp	306	13	has	have	VBZ
cord-283382-t890r7xp	306	14	advanced	advance	VBN
cord-283382-t890r7xp	306	15	into	into	IN
cord-283382-t890r7xp	306	16	clinical	clinical	JJ
cord-283382-t890r7xp	306	17	studies	study	NNS
cord-283382-t890r7xp	306	18	as	as	IN
cord-283382-t890r7xp	306	19	a	a	DT
cord-283382-t890r7xp	306	20	vaccine	vaccine	NN
cord-283382-t890r7xp	306	21	against	against	IN
cord-283382-t890r7xp	306	22	Ebola	Ebola	NNP
cord-283382-t890r7xp	306	23	virus	virus	NN
cord-283382-t890r7xp	306	24	(	(	-LRB-
cord-283382-t890r7xp	306	25	178	178	CD
cord-283382-t890r7xp	306	26	)	)	-RRB-
cord-283382-t890r7xp	306	27	(	(	-LRB-
cord-283382-t890r7xp	306	28	179	179	LS
cord-283382-t890r7xp	306	29	)	)	-RRB-
cord-283382-t890r7xp	306	30	(	(	-LRB-
cord-283382-t890r7xp	306	31	180	180	CD
cord-283382-t890r7xp	306	32	)	)	-RRB-
cord-283382-t890r7xp	306	33	,	,	,
cord-283382-t890r7xp	306	34	RSV	RSV	NNP
cord-283382-t890r7xp	306	35	(	(	-LRB-
cord-283382-t890r7xp	306	36	181	181	CD
cord-283382-t890r7xp	306	37	)	)	-RRB-
cord-283382-t890r7xp	306	38	,	,	,
cord-283382-t890r7xp	306	39	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	306	40	(	(	-LRB-
cord-283382-t890r7xp	306	41	6	6	CD
cord-283382-t890r7xp	306	42	,	,	,
cord-283382-t890r7xp	306	43	182	182	CD
cord-283382-t890r7xp	306	44	,	,	,
cord-283382-t890r7xp	306	45	183	183	CD
cord-283382-t890r7xp	306	46	)	)	-RRB-
cord-283382-t890r7xp	306	47	,	,	,
cord-283382-t890r7xp	306	48	and	and	CC
cord-283382-t890r7xp	306	49	has	have	VBZ
cord-283382-t890r7xp	306	50	also	also	RB
cord-283382-t890r7xp	306	51	very	very	RB
cord-283382-t890r7xp	306	52	recently	recently	RB
cord-283382-t890r7xp	306	53	been	be	VBN
cord-283382-t890r7xp	306	54	announced	announce	VBN
cord-283382-t890r7xp	306	55	as	as	IN
cord-283382-t890r7xp	306	56	a	a	DT
cord-283382-t890r7xp	306	57	candidate	candidate	NN
cord-283382-t890r7xp	306	58	vectored	vectore	VBD
cord-283382-t890r7xp	306	59	vaccine	vaccine	NN
cord-283382-t890r7xp	306	60	against	against	IN
cord-283382-t890r7xp	306	61	COVID-19	COVID-19	NNP
cord-283382-t890r7xp	306	62	.	.	.
cord-283382-t890r7xp	307	1	The	the	DT
cord-283382-t890r7xp	307	2	first	first	JJ
cord-283382-t890r7xp	307	3	-	-	HYPH
cord-283382-t890r7xp	307	4	in	in	IN
cord-283382-t890r7xp	307	5	-	-	HYPH
cord-283382-t890r7xp	307	6	human	human	JJ
cord-283382-t890r7xp	307	7	testing	testing	NN
cord-283382-t890r7xp	307	8	of	of	IN
cord-283382-t890r7xp	307	9	HAdV	HAdV	NNP
cord-283382-t890r7xp	307	10	-	-	HYPH
cord-283382-t890r7xp	307	11	D26	D26	NNP
cord-283382-t890r7xp	307	12	expressing	express	VBG
cord-283382-t890r7xp	307	13	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	307	14	Env	Env	NNP
cord-283382-t890r7xp	307	15	demonstrated	demonstrate	VBD
cord-283382-t890r7xp	307	16	that	that	IN
cord-283382-t890r7xp	307	17	the	the	DT
cord-283382-t890r7xp	307	18	vaccine	vaccine	NN
cord-283382-t890r7xp	307	19	was	be	VBD
cord-283382-t890r7xp	307	20	safe	safe	JJ
cord-283382-t890r7xp	307	21	and	and	CC
cord-283382-t890r7xp	307	22	well	well	RB
cord-283382-t890r7xp	307	23	-	-	HYPH
cord-283382-t890r7xp	307	24	tolerated	tolerate	VBN
cord-283382-t890r7xp	307	25	and	and	CC
cord-283382-t890r7xp	307	26	elicited	elicit	VBN
cord-283382-t890r7xp	307	27	Env	env	NN
cord-283382-t890r7xp	307	28	-	-	HYPH
cord-283382-t890r7xp	307	29	specific	specific	JJ
cord-283382-t890r7xp	307	30	antibodies	antibody	NNS
cord-283382-t890r7xp	307	31	and	and	CC
cord-283382-t890r7xp	307	32	antigen	antigen	NN
cord-283382-t890r7xp	307	33	-	-	HYPH
cord-283382-t890r7xp	307	34	specific	specific	JJ
cord-283382-t890r7xp	307	35	ELISpot	elispot	NN
cord-283382-t890r7xp	307	36	responses	response	NNS
cord-283382-t890r7xp	307	37	in	in	IN
cord-283382-t890r7xp	307	38	all	all	DT
cord-283382-t890r7xp	307	39	participants	participant	NNS
cord-283382-t890r7xp	307	40	(	(	-LRB-
cord-283382-t890r7xp	307	41	182	182	CD
cord-283382-t890r7xp	307	42	)	)	-RRB-
cord-283382-t890r7xp	307	43	.	.	.
cord-283382-t890r7xp	308	1	Although	although	IN
cord-283382-t890r7xp	308	2	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	308	3	specific	specific	JJ
cord-283382-t890r7xp	308	4	neutralizing	neutralize	VBG
cord-283382-t890r7xp	308	5	antibodies	antibody	NNS
cord-283382-t890r7xp	308	6	were	be	VBD
cord-283382-t890r7xp	308	7	not	not	RB
cord-283382-t890r7xp	308	8	detected	detect	VBN
cord-283382-t890r7xp	308	9	,	,	,
cord-283382-t890r7xp	308	10	the	the	DT
cord-283382-t890r7xp	308	11	study	study	NN
cord-283382-t890r7xp	308	12	reported	report	VBD
cord-283382-t890r7xp	308	13	multi	multi	JJ
cord-283382-t890r7xp	308	14	-	-	JJ
cord-283382-t890r7xp	308	15	functional	functional	JJ
cord-283382-t890r7xp	308	16	readouts	readout	NNS
cord-283382-t890r7xp	308	17	for	for	IN
cord-283382-t890r7xp	308	18	the	the	DT
cord-283382-t890r7xp	308	19	non	non	JJ
cord-283382-t890r7xp	308	20	-	-	JJ
cord-283382-t890r7xp	308	21	neutralizing	neutralize	VBG
cord-283382-t890r7xp	308	22	antibodies	antibody	NNS
cord-283382-t890r7xp	308	23	elicited	elicit	VBN
cord-283382-t890r7xp	308	24	,	,	,
cord-283382-t890r7xp	308	25	including	include	VBG
cord-283382-t890r7xp	308	26	effector	effector	NN
cord-283382-t890r7xp	308	27	functions	function	NNS
cord-283382-t890r7xp	308	28	such	such	JJ
cord-283382-t890r7xp	308	29	as	as	IN
cord-283382-t890r7xp	308	30	antibody	antibody	NN
cord-283382-t890r7xp	308	31	-	-	HYPH
cord-283382-t890r7xp	308	32	dependent	dependent	JJ
cord-283382-t890r7xp	308	33	cell	cell	NN
cord-283382-t890r7xp	308	34	-	-	HYPH
cord-283382-t890r7xp	308	35	mediated	mediate	VBN
cord-283382-t890r7xp	308	36	phagocytosis	phagocytosis	NN
cord-283382-t890r7xp	308	37	(	(	-LRB-
cord-283382-t890r7xp	308	38	ADCP	ADCP	NNP
cord-283382-t890r7xp	308	39	)	)	-RRB-
cord-283382-t890r7xp	308	40	,	,	,
cord-283382-t890r7xp	308	41	antibody	antibody	NN
cord-283382-t890r7xp	308	42	-	-	HYPH
cord-283382-t890r7xp	308	43	dependent	dependent	JJ
cord-283382-t890r7xp	308	44	cell	cell	NN
cord-283382-t890r7xp	308	45	-	-	HYPH
cord-283382-t890r7xp	308	46	mediated	mediate	VBN
cord-283382-t890r7xp	308	47	virus	virus	NN
cord-283382-t890r7xp	308	48	inhibition	inhibition	NN
cord-283382-t890r7xp	308	49	(	(	-LRB-
cord-283382-t890r7xp	308	50	ADCVI	ADCVI	NNP
cord-283382-t890r7xp	308	51	)	)	-RRB-
cord-283382-t890r7xp	308	52	(	(	-LRB-
cord-283382-t890r7xp	308	53	183	183	CD
cord-283382-t890r7xp	308	54	)	)	-RRB-
cord-283382-t890r7xp	308	55	.	.	.
cord-283382-t890r7xp	309	1	This	this	DT
cord-283382-t890r7xp	309	2	vaccine	vaccine	NN
cord-283382-t890r7xp	309	3	platform	platform	NN
cord-283382-t890r7xp	309	4	was	be	VBD
cord-283382-t890r7xp	309	5	subsequently	subsequently	RB
cord-283382-t890r7xp	309	6	improved	improve	VBN
cord-283382-t890r7xp	309	7	upon	upon	IN
cord-283382-t890r7xp	309	8	by	by	IN
cord-283382-t890r7xp	309	9	encoding	encode	VBG
cord-283382-t890r7xp	309	10	polyvalent	polyvalent	JJ
cord-283382-t890r7xp	309	11	"	"	``
cord-283382-t890r7xp	309	12	mosaic	mosaic	JJ
cord-283382-t890r7xp	309	13	"	"	''
cord-283382-t890r7xp	309	14	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	309	15	antigens	antigen	NNS
cord-283382-t890r7xp	309	16	,	,	,
cord-283382-t890r7xp	309	17	Env	Env	NNP
cord-283382-t890r7xp	309	18	,	,	,
cord-283382-t890r7xp	309	19	Gag	Gag	NNP
cord-283382-t890r7xp	309	20	and	and	CC
cord-283382-t890r7xp	309	21	Pol	Pol	NNP
cord-283382-t890r7xp	309	22	,	,	,
cord-283382-t890r7xp	309	23	representing	represent	VBG
cord-283382-t890r7xp	309	24	computationally	computationally	RB
cord-283382-t890r7xp	309	25	optimized	optimize	VBN
cord-283382-t890r7xp	309	26	sequences	sequence	NNS
cord-283382-t890r7xp	309	27	aimed	aim	VBN
cord-283382-t890r7xp	309	28	at	at	IN
cord-283382-t890r7xp	309	29	maximizing	maximize	VBG
cord-283382-t890r7xp	309	30	recognition	recognition	NN
cord-283382-t890r7xp	309	31	of	of	IN
cord-283382-t890r7xp	309	32	T	T	NNP
cord-283382-t890r7xp	309	33	cell	cell	NN
cord-283382-t890r7xp	309	34	epitopes	epitope	NNS
cord-283382-t890r7xp	309	35	(	(	-LRB-
cord-283382-t890r7xp	309	36	184	184	CD
cord-283382-t890r7xp	309	37	)	)	-RRB-
cord-283382-t890r7xp	309	38	.	.	.
cord-283382-t890r7xp	310	1	Evaluation	evaluation	NN
cord-283382-t890r7xp	310	2	of	of	IN
cord-283382-t890r7xp	310	3	the	the	DT
cord-283382-t890r7xp	310	4	HAdV	HAdV	NNP
cord-283382-t890r7xp	310	5	-	-	HYPH
cord-283382-t890r7xp	310	6	D26	D26	NNP
cord-283382-t890r7xp	310	7	platform	platform	NN
cord-283382-t890r7xp	310	8	in	in	IN
cord-283382-t890r7xp	310	9	various	various	JJ
cord-283382-t890r7xp	310	10	prime	prime	NN
cord-283382-t890r7xp	310	11	:	:	:
cord-283382-t890r7xp	310	12	boost	boost	NN
cord-283382-t890r7xp	310	13	regimens	regimen	NNS
cord-283382-t890r7xp	310	14	is	be	VBZ
cord-283382-t890r7xp	310	15	ongoing	ongoing	JJ
cord-283382-t890r7xp	310	16	and	and	CC
cord-283382-t890r7xp	310	17	preliminary	preliminary	JJ
cord-283382-t890r7xp	310	18	data	datum	NNS
cord-283382-t890r7xp	310	19	suggest	suggest	VBP
cord-283382-t890r7xp	310	20	that	that	IN
cord-283382-t890r7xp	310	21	it	-PRON-	PRP
cord-283382-t890r7xp	310	22	is	be	VBZ
cord-283382-t890r7xp	310	23	immunogenic	immunogenic	JJ
cord-283382-t890r7xp	310	24	,	,	,
cord-283382-t890r7xp	310	25	capable	capable	JJ
cord-283382-t890r7xp	310	26	of	of	IN
cord-283382-t890r7xp	310	27	eliciting	elicit	VBG
cord-283382-t890r7xp	310	28	Env	env	NN
cord-283382-t890r7xp	310	29	-	-	HYPH
cord-283382-t890r7xp	310	30	specific	specific	JJ
cord-283382-t890r7xp	310	31	antibodies	antibody	NNS
cord-283382-t890r7xp	310	32	which	which	WDT
cord-283382-t890r7xp	310	33	exhibit	exhibit	VBP
cord-283382-t890r7xp	310	34	ADCP	ADCP	NNP
cord-283382-t890r7xp	310	35	and	and	CC
cord-283382-t890r7xp	310	36	cellular	cellular	JJ
cord-283382-t890r7xp	310	37	immune	immune	JJ
cord-283382-t890r7xp	310	38	responses	response	NNS
cord-283382-t890r7xp	310	39	out	out	IN
cord-283382-t890r7xp	310	40	to	to	IN
cord-283382-t890r7xp	310	41	week	week	NN
cord-283382-t890r7xp	310	42	50	50	CD
cord-283382-t890r7xp	310	43	.	.	.
cord-283382-t890r7xp	311	1	Importantly	importantly	RB
cord-283382-t890r7xp	311	2	,	,	,
cord-283382-t890r7xp	311	3	these	these	DT
cord-283382-t890r7xp	311	4	assays	assay	NNS
cord-283382-t890r7xp	311	5	were	be	VBD
cord-283382-t890r7xp	311	6	found	find	VBN
cord-283382-t890r7xp	311	7	to	to	TO
cord-283382-t890r7xp	311	8	be	be	VB
cord-283382-t890r7xp	311	9	correlates	correlate	NNS
cord-283382-t890r7xp	311	10	of	of	IN
cord-283382-t890r7xp	311	11	protection	protection	NN
cord-283382-t890r7xp	311	12	in	in	IN
cord-283382-t890r7xp	311	13	a	a	DT
cord-283382-t890r7xp	311	14	parallel	parallel	JJ
cord-283382-t890r7xp	311	15	SHIV	SHIV	NNP
cord-283382-t890r7xp	311	16	challenge	challenge	NN
cord-283382-t890r7xp	311	17	model	model	NN
cord-283382-t890r7xp	311	18	in	in	IN
cord-283382-t890r7xp	311	19	rhesus	rhesu	NNS
cord-283382-t890r7xp	311	20	monkeys	monkey	NNS
cord-283382-t890r7xp	311	21	(	(	-LRB-
cord-283382-t890r7xp	311	22	Macaca	Macaca	NNP
cord-283382-t890r7xp	311	23	mulatta	mulatta	NNP
cord-283382-t890r7xp	311	24	)	)	-RRB-
cord-283382-t890r7xp	311	25	(	(	-LRB-
cord-283382-t890r7xp	311	26	6	6	CD
cord-283382-t890r7xp	311	27	)	)	-RRB-
cord-283382-t890r7xp	311	28	.	.	.
cord-283382-t890r7xp	312	1	The	the	DT
cord-283382-t890r7xp	312	2	HAdV	HAdV	NNP
cord-283382-t890r7xp	312	3	-	-	HYPH
cord-283382-t890r7xp	312	4	D26	D26	NNP
cord-283382-t890r7xp	312	5	mosaic	mosaic	NN
cord-283382-t890r7xp	312	6	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	312	7	vaccine	vaccine	NN
cord-283382-t890r7xp	312	8	is	be	VBZ
cord-283382-t890r7xp	312	9	currently	currently	RB
cord-283382-t890r7xp	312	10	in	in	IN
cord-283382-t890r7xp	312	11	Phase	phase	NN
cord-283382-t890r7xp	312	12	IIb	iib	JJ
cord-283382-t890r7xp	312	13	efficacy	efficacy	NN
cord-283382-t890r7xp	312	14	studies	study	NNS
cord-283382-t890r7xp	312	15	in	in	IN
cord-283382-t890r7xp	312	16	sub	sub	JJ
cord-283382-t890r7xp	312	17	-	-	JJ
cord-283382-t890r7xp	312	18	saharan	saharan	JJ
cord-283382-t890r7xp	312	19	Africa	Africa	NNP
cord-283382-t890r7xp	313	1	(	(	-LRB-
cord-283382-t890r7xp	313	2	NCT03060629	NCT03060629	NNP
cord-283382-t890r7xp	313	3	)	)	-RRB-
cord-283382-t890r7xp	313	4	.	.	.
cord-283382-t890r7xp	314	1	Based	base	VBN
cord-283382-t890r7xp	314	2	on	on	IN
cord-283382-t890r7xp	314	3	the	the	DT
cord-283382-t890r7xp	314	4	literature	literature	NN
cord-283382-t890r7xp	314	5	,	,	,
cord-283382-t890r7xp	314	6	it	-PRON-	PRP
cord-283382-t890r7xp	314	7	appears	appear	VBZ
cord-283382-t890r7xp	314	8	that	that	IN
cord-283382-t890r7xp	314	9	Ad	ad	NN
cord-283382-t890r7xp	314	10	vectors	vector	NNS
cord-283382-t890r7xp	314	11	derived	derive	VBN
cord-283382-t890r7xp	314	12	from	from	IN
cord-283382-t890r7xp	314	13	species	specie	NNS
cord-283382-t890r7xp	314	14	C	C	NNP
cord-283382-t890r7xp	314	15	,	,	,
cord-283382-t890r7xp	314	16	D	D	NNP
cord-283382-t890r7xp	314	17	,	,	,
cord-283382-t890r7xp	314	18	or	or	CC
cord-283382-t890r7xp	314	19	E	e	NN
cord-283382-t890r7xp	314	20	are	be	VBP
cord-283382-t890r7xp	314	21	most	most	RBS
cord-283382-t890r7xp	314	22	likely	likely	JJ
cord-283382-t890r7xp	314	23	to	to	TO
cord-283382-t890r7xp	314	24	be	be	VB
cord-283382-t890r7xp	314	25	immunogenic	immunogenic	JJ
cord-283382-t890r7xp	314	26	vectors	vector	NNS
cord-283382-t890r7xp	314	27	.	.	.
cord-283382-t890r7xp	315	1	Requirements	requirement	NNS
cord-283382-t890r7xp	315	2	for	for	IN
cord-283382-t890r7xp	315	3	selecting	select	VBG
cord-283382-t890r7xp	315	4	specific	specific	JJ
cord-283382-t890r7xp	315	5	vectors	vector	NNS
cord-283382-t890r7xp	315	6	will	will	MD
cord-283382-t890r7xp	315	7	vary	vary	VB
cord-283382-t890r7xp	315	8	depending	depend	VBG
cord-283382-t890r7xp	315	9	on	on	IN
cord-283382-t890r7xp	315	10	whether	whether	IN
cord-283382-t890r7xp	315	11	the	the	DT
cord-283382-t890r7xp	315	12	required	required	JJ
cord-283382-t890r7xp	315	13	application	application	NN
cord-283382-t890r7xp	315	14	is	be	VBZ
cord-283382-t890r7xp	315	15	as	as	IN
cord-283382-t890r7xp	315	16	a	a	DT
cord-283382-t890r7xp	315	17	stand	stand	VB
cord-283382-t890r7xp	315	18	-	-	HYPH
cord-283382-t890r7xp	315	19	alone	alone	RB
cord-283382-t890r7xp	315	20	vaccine	vaccine	NN
cord-283382-t890r7xp	315	21	or	or	CC
cord-283382-t890r7xp	315	22	as	as	IN
cord-283382-t890r7xp	315	23	part	part	NN
cord-283382-t890r7xp	315	24	of	of	IN
cord-283382-t890r7xp	315	25	a	a	DT
cord-283382-t890r7xp	315	26	prime	prime	NN
cord-283382-t890r7xp	315	27	:	:	:
cord-283382-t890r7xp	315	28	boost	boost	VB
cord-283382-t890r7xp	315	29	regimen	regimen	NN
cord-283382-t890r7xp	315	30	.	.	.
cord-283382-t890r7xp	316	1	For	for	IN
cord-283382-t890r7xp	316	2	standalone	standalone	JJ
cord-283382-t890r7xp	316	3	vaccination	vaccination	NN
cord-283382-t890r7xp	316	4	regimens	regimen	NNS
cord-283382-t890r7xp	316	5	aimed	aim	VBN
cord-283382-t890r7xp	316	6	at	at	IN
cord-283382-t890r7xp	316	7	eliciting	elicit	VBG
cord-283382-t890r7xp	316	8	a	a	DT
cord-283382-t890r7xp	316	9	rapid	rapid	JJ
cord-283382-t890r7xp	316	10	,	,	,
cord-283382-t890r7xp	316	11	protective	protective	JJ
cord-283382-t890r7xp	316	12	response	response	NN
cord-283382-t890r7xp	316	13	during	during	IN
cord-283382-t890r7xp	316	14	an	an	DT
cord-283382-t890r7xp	316	15	emerging	emerge	VBG
cord-283382-t890r7xp	316	16	pandemic	pandemic	NN
cord-283382-t890r7xp	316	17	,	,	,
cord-283382-t890r7xp	316	18	the	the	DT
cord-283382-t890r7xp	316	19	magnitude	magnitude	NN
cord-283382-t890r7xp	316	20	of	of	IN
cord-283382-t890r7xp	316	21	response	response	NN
cord-283382-t890r7xp	316	22	to	to	IN
cord-283382-t890r7xp	316	23	an	an	DT
cord-283382-t890r7xp	316	24	identified	identify	VBN
cord-283382-t890r7xp	316	25	correlate	correlate	NN
cord-283382-t890r7xp	316	26	of	of	IN
cord-283382-t890r7xp	316	27	protection	protection	NN
cord-283382-t890r7xp	316	28	following	follow	VBG
cord-283382-t890r7xp	316	29	a	a	DT
cord-283382-t890r7xp	316	30	single	single	JJ
cord-283382-t890r7xp	316	31	shot	shot	NN
cord-283382-t890r7xp	316	32	is	be	VBZ
cord-283382-t890r7xp	316	33	crucial	crucial	JJ
cord-283382-t890r7xp	316	34	.	.	.
cord-283382-t890r7xp	317	1	Secondary	secondary	JJ
cord-283382-t890r7xp	317	2	considerations	consideration	NNS
cord-283382-t890r7xp	317	3	for	for	IN
cord-283382-t890r7xp	317	4	an	an	DT
cord-283382-t890r7xp	317	5	evolving	evolve	VBG
cord-283382-t890r7xp	317	6	pandemic	pandemic	NN
cord-283382-t890r7xp	317	7	scenario	scenario	NN
cord-283382-t890r7xp	317	8	would	would	MD
cord-283382-t890r7xp	317	9	be	be	VB
cord-283382-t890r7xp	317	10	rapid	rapid	JJ
cord-283382-t890r7xp	317	11	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	317	12	at	at	IN
cord-283382-t890r7xp	317	13	a	a	DT
cord-283382-t890r7xp	317	14	low	low	JJ
cord-283382-t890r7xp	317	15	dose	dose	NN
cord-283382-t890r7xp	317	16	,	,	,
cord-283382-t890r7xp	317	17	and	and	CC
cord-283382-t890r7xp	317	18	the	the	DT
cord-283382-t890r7xp	317	19	capacity	capacity	NN
cord-283382-t890r7xp	317	20	for	for	IN
cord-283382-t890r7xp	317	21	lyophilization	lyophilization	NN
cord-283382-t890r7xp	317	22	or	or	CC
cord-283382-t890r7xp	317	23	stabilization	stabilization	NN
cord-283382-t890r7xp	317	24	,	,	,
cord-283382-t890r7xp	317	25	to	to	TO
cord-283382-t890r7xp	317	26	facilitate	facilitate	VB
cord-283382-t890r7xp	317	27	dose	dose	NN
cord-283382-t890r7xp	317	28	-	-	HYPH
cord-283382-t890r7xp	317	29	sparing	sparing	NN
cord-283382-t890r7xp	317	30	,	,	,
cord-283382-t890r7xp	317	31	vaccine	vaccine	NN
cord-283382-t890r7xp	317	32	cost	cost	NN
cord-283382-t890r7xp	317	33	-	-	HYPH
cord-283382-t890r7xp	317	34	effectiveness	effectiveness	NN
cord-283382-t890r7xp	317	35	and	and	CC
cord-283382-t890r7xp	317	36	pandemic	pandemic	NN
cord-283382-t890r7xp	317	37	preparedness	preparedness	NN
cord-283382-t890r7xp	317	38	.	.	.
cord-283382-t890r7xp	318	1	In	in	IN
cord-283382-t890r7xp	318	2	this	this	DT
cord-283382-t890r7xp	318	3	regard	regard	NN
cord-283382-t890r7xp	318	4	,	,	,
cord-283382-t890r7xp	318	5	of	of	IN
cord-283382-t890r7xp	318	6	the	the	DT
cord-283382-t890r7xp	318	7	Ad	ad	NN
cord-283382-t890r7xp	318	8	vectors	vector	NNS
cord-283382-t890r7xp	318	9	evaluated	evaluate	VBN
cord-283382-t890r7xp	318	10	to	to	IN
cord-283382-t890r7xp	318	11	date	date	NN
cord-283382-t890r7xp	318	12	,	,	,
cord-283382-t890r7xp	318	13	ChAdV-3	chadv-3	NN
cord-283382-t890r7xp	318	14	and	and	CC
cord-283382-t890r7xp	318	15	HAdV	HAdV	NNP
cord-283382-t890r7xp	318	16	-	-	HYPH
cord-283382-t890r7xp	318	17	C6	C6	NNP
cord-283382-t890r7xp	318	18	appear	appear	VBP
cord-283382-t890r7xp	318	19	promising	promising	JJ
cord-283382-t890r7xp	318	20	.	.	.
cord-283382-t890r7xp	319	1	For	for	IN
cord-283382-t890r7xp	319	2	protection	protection	NN
cord-283382-t890r7xp	319	3	against	against	IN
cord-283382-t890r7xp	319	4	more	more	JJR
cord-283382-t890r7xp	319	5	complex	complex	JJ
cord-283382-t890r7xp	319	6	pathogens	pathogen	NNS
cord-283382-t890r7xp	319	7	which	which	WDT
cord-283382-t890r7xp	319	8	require	require	VBP
cord-283382-t890r7xp	319	9	long	long	RB
cord-283382-t890r7xp	319	10	-	-	HYPH
cord-283382-t890r7xp	319	11	lived	live	VBN
cord-283382-t890r7xp	319	12	polyfunctional	polyfunctional	JJ
cord-283382-t890r7xp	319	13	responses	response	NNS
cord-283382-t890r7xp	319	14	,	,	,
cord-283382-t890r7xp	319	15	or	or	CC
cord-283382-t890r7xp	319	16	sustained	sustain	VBN
cord-283382-t890r7xp	319	17	humoral	humoral	JJ
cord-283382-t890r7xp	319	18	immunity	immunity	NN
cord-283382-t890r7xp	319	19	with	with	IN
cord-283382-t890r7xp	319	20	extensive	extensive	JJ
cord-283382-t890r7xp	319	21	breadth	breadth	NN
cord-283382-t890r7xp	319	22	(	(	-LRB-
cord-283382-t890r7xp	319	23	i.e.	i.e.	FW
cord-283382-t890r7xp	319	24	,	,	,
cord-283382-t890r7xp	319	25	universal	universal	JJ
cord-283382-t890r7xp	319	26	influenza	influenza	NN
cord-283382-t890r7xp	319	27	vaccine	vaccine	NN
cord-283382-t890r7xp	319	28	,	,	,
cord-283382-t890r7xp	319	29	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	319	30	or	or	CC
cord-283382-t890r7xp	319	31	HCV	HCV	NNP
cord-283382-t890r7xp	319	32	)	)	-RRB-
cord-283382-t890r7xp	319	33	,	,	,
cord-283382-t890r7xp	319	34	heterologous	heterologous	JJ
cord-283382-t890r7xp	319	35	prime	prime	NN
cord-283382-t890r7xp	319	36	:	:	:
cord-283382-t890r7xp	319	37	boost	boost	VB
cord-283382-t890r7xp	319	38	vaccination	vaccination	NN
cord-283382-t890r7xp	319	39	regimens	regimen	NNS
cord-283382-t890r7xp	319	40	should	should	MD
cord-283382-t890r7xp	319	41	be	be	VB
cord-283382-t890r7xp	319	42	evaluated	evaluate	VBN
cord-283382-t890r7xp	319	43	using	use	VBG
cord-283382-t890r7xp	319	44	diverse	diverse	JJ
cord-283382-t890r7xp	319	45	Ad	ad	NN
cord-283382-t890r7xp	319	46	vectors	vector	NNS
cord-283382-t890r7xp	319	47	,	,	,
cord-283382-t890r7xp	319	48	or	or	CC
cord-283382-t890r7xp	319	49	Ads	ad	NNS
cord-283382-t890r7xp	319	50	in	in	IN
cord-283382-t890r7xp	319	51	combination	combination	NN
cord-283382-t890r7xp	319	52	with	with	IN
cord-283382-t890r7xp	319	53	MVA	MVA	NNP
cord-283382-t890r7xp	319	54	or	or	CC
cord-283382-t890r7xp	319	55	protein	protein	NN
cord-283382-t890r7xp	319	56	based	base	VBN
cord-283382-t890r7xp	319	57	immunogens	immunogen	NNS
cord-283382-t890r7xp	319	58	at	at	IN
cord-283382-t890r7xp	319	59	different	different	JJ
cord-283382-t890r7xp	319	60	intervals	interval	NNS
cord-283382-t890r7xp	319	61	.	.	.
cord-283382-t890r7xp	320	1	It	-PRON-	PRP
cord-283382-t890r7xp	320	2	is	be	VBZ
cord-283382-t890r7xp	320	3	difficult	difficult	JJ
cord-283382-t890r7xp	320	4	to	to	TO
cord-283382-t890r7xp	320	5	predict	predict	VB
cord-283382-t890r7xp	320	6	which	which	WDT
cord-283382-t890r7xp	320	7	Ad	ad	NN
cord-283382-t890r7xp	320	8	vectors	vector	NNS
cord-283382-t890r7xp	320	9	should	should	MD
cord-283382-t890r7xp	320	10	take	take	VB
cord-283382-t890r7xp	320	11	precedence	precedence	NN
cord-283382-t890r7xp	320	12	as	as	IN
cord-283382-t890r7xp	320	13	the	the	DT
cord-283382-t890r7xp	320	14	encoded	encoded	JJ
cord-283382-t890r7xp	320	15	antigen	antigen	NN
cord-283382-t890r7xp	320	16	will	will	MD
cord-283382-t890r7xp	320	17	need	need	VB
cord-283382-t890r7xp	320	18	to	to	TO
cord-283382-t890r7xp	320	19	be	be	VB
cord-283382-t890r7xp	320	20	tailored	tailor	VBN
cord-283382-t890r7xp	320	21	to	to	TO
cord-283382-t890r7xp	320	22	elicit	elicit	VB
cord-283382-t890r7xp	320	23	the	the	DT
cord-283382-t890r7xp	320	24	correct	correct	JJ
cord-283382-t890r7xp	320	25	phenotype	phenotype	NN
cord-283382-t890r7xp	320	26	of	of	IN
cord-283382-t890r7xp	320	27	immunity	immunity	NN
cord-283382-t890r7xp	320	28	against	against	IN
cord-283382-t890r7xp	320	29	a	a	DT
cord-283382-t890r7xp	320	30	defined	define	VBN
cord-283382-t890r7xp	320	31	correlate	correlate	NN
cord-283382-t890r7xp	320	32	of	of	IN
cord-283382-t890r7xp	320	33	protection	protection	NN
cord-283382-t890r7xp	320	34	for	for	IN
cord-283382-t890r7xp	320	35	each	each	DT
cord-283382-t890r7xp	320	36	specific	specific	JJ
cord-283382-t890r7xp	320	37	disease	disease	NN
cord-283382-t890r7xp	320	38	target	target	NN
cord-283382-t890r7xp	320	39	.	.	.
cord-283382-t890r7xp	321	1	However	however	RB
cord-283382-t890r7xp	321	2	,	,	,
cord-283382-t890r7xp	321	3	underpinning	underpin	VBG
cord-283382-t890r7xp	321	4	the	the	DT
cord-283382-t890r7xp	321	5	evaluation	evaluation	NN
cord-283382-t890r7xp	321	6	of	of	IN
cord-283382-t890r7xp	321	7	all	all	DT
cord-283382-t890r7xp	321	8	Ad	ad	NN
cord-283382-t890r7xp	321	9	-	-	HYPH
cord-283382-t890r7xp	321	10	based	base	VBN
cord-283382-t890r7xp	321	11	vaccines	vaccine	NNS
cord-283382-t890r7xp	321	12	in	in	IN
cord-283382-t890r7xp	321	13	pre	pre	JJ
cord-283382-t890r7xp	321	14	-	-	JJ
cord-283382-t890r7xp	321	15	clinical	clinical	JJ
cord-283382-t890r7xp	321	16	animal	animal	NN
cord-283382-t890r7xp	321	17	studies	study	NNS
cord-283382-t890r7xp	321	18	,	,	,
cord-283382-t890r7xp	321	19	should	should	MD
cord-283382-t890r7xp	321	20	be	be	VB
cord-283382-t890r7xp	321	21	the	the	DT
cord-283382-t890r7xp	321	22	inclusion	inclusion	NN
cord-283382-t890r7xp	321	23	of	of	IN
cord-283382-t890r7xp	321	24	species	specie	NNS
cord-283382-t890r7xp	321	25	C	C	NNP
cord-283382-t890r7xp	321	26	Ad5	ad5	CD
cord-283382-t890r7xp	321	27	vector	vector	NN
cord-283382-t890r7xp	321	28	controls	control	NNS
cord-283382-t890r7xp	321	29	to	to	TO
cord-283382-t890r7xp	321	30	represent	represent	VB
cord-283382-t890r7xp	321	31	a	a	DT
cord-283382-t890r7xp	321	32	benchmark	benchmark	NN
cord-283382-t890r7xp	321	33	of	of	IN
cord-283382-t890r7xp	321	34	immunological	immunological	JJ
cord-283382-t890r7xp	321	35	potency	potency	NN
cord-283382-t890r7xp	321	36	.	.	.
cord-283382-t890r7xp	322	1	In	in	IN
cord-283382-t890r7xp	322	2	addition	addition	NN
cord-283382-t890r7xp	322	3	,	,	,
cord-283382-t890r7xp	322	4	Ad	ad	NN
cord-283382-t890r7xp	322	5	vaccine	vaccine	NN
cord-283382-t890r7xp	322	6	candidates	candidate	NNS
cord-283382-t890r7xp	322	7	should	should	MD
cord-283382-t890r7xp	322	8	be	be	VB
cord-283382-t890r7xp	322	9	compared	compare	VBN
cord-283382-t890r7xp	322	10	at	at	IN
cord-283382-t890r7xp	322	11	several	several	JJ
cord-283382-t890r7xp	322	12	doses	dose	NNS
cord-283382-t890r7xp	322	13	to	to	TO
cord-283382-t890r7xp	322	14	evaluate	evaluate	VB
cord-283382-t890r7xp	322	15	the	the	DT
cord-283382-t890r7xp	322	16	maintenance	maintenance	NN
cord-283382-t890r7xp	322	17	of	of	IN
cord-283382-t890r7xp	322	18	vaccine	vaccine	NN
cord-283382-t890r7xp	322	19	potency	potency	NN
cord-283382-t890r7xp	322	20	upon	upon	IN
cord-283382-t890r7xp	322	21	dose	dose	NN
cord-283382-t890r7xp	322	22	de	de	NN
cord-283382-t890r7xp	322	23	-	-	NN
cord-283382-t890r7xp	322	24	escalation	escalation	NN
cord-283382-t890r7xp	322	25	.	.	.
cord-283382-t890r7xp	323	1	The	the	DT
cord-283382-t890r7xp	323	2	field	field	NN
cord-283382-t890r7xp	323	3	should	should	MD
cord-283382-t890r7xp	323	4	also	also	RB
cord-283382-t890r7xp	323	5	make	make	VB
cord-283382-t890r7xp	323	6	efforts	effort	NNS
cord-283382-t890r7xp	323	7	to	to	TO
cord-283382-t890r7xp	323	8	improve	improve	VB
cord-283382-t890r7xp	323	9	our	-PRON-	PRP$
cord-283382-t890r7xp	323	10	understanding	understanding	NN
cord-283382-t890r7xp	323	11	of	of	IN
cord-283382-t890r7xp	323	12	the	the	DT
cord-283382-t890r7xp	323	13	basic	basic	JJ
cord-283382-t890r7xp	323	14	biology	biology	NN
cord-283382-t890r7xp	323	15	of	of	IN
cord-283382-t890r7xp	323	16	many	many	JJ
cord-283382-t890r7xp	323	17	of	of	IN
cord-283382-t890r7xp	323	18	these	these	DT
cord-283382-t890r7xp	323	19	novel	novel	JJ
cord-283382-t890r7xp	323	20	Ad	ad	NN
cord-283382-t890r7xp	323	21	vectors	vector	NNS
cord-283382-t890r7xp	323	22	,	,	,
cord-283382-t890r7xp	323	23	as	as	IN
cord-283382-t890r7xp	323	24	insights	insight	NNS
cord-283382-t890r7xp	323	25	into	into	IN
cord-283382-t890r7xp	323	26	the	the	DT
cord-283382-t890r7xp	323	27	receptor	receptor	NN
cord-283382-t890r7xp	323	28	usage	usage	NN
cord-283382-t890r7xp	323	29	,	,	,
cord-283382-t890r7xp	323	30	interactions	interaction	NNS
cord-283382-t890r7xp	323	31	of	of	IN
cord-283382-t890r7xp	323	32	Ad	ad	NN
cord-283382-t890r7xp	323	33	vectors	vector	NNS
cord-283382-t890r7xp	323	34	with	with	IN
cord-283382-t890r7xp	323	35	different	different	JJ
cord-283382-t890r7xp	323	36	cell	cell	NN
cord-283382-t890r7xp	323	37	types	type	NNS
cord-283382-t890r7xp	323	38	following	follow	VBG
cord-283382-t890r7xp	323	39	immunization	immunization	NN
cord-283382-t890r7xp	323	40	and	and	CC
cord-283382-t890r7xp	323	41	subsequent	subsequent	JJ
cord-283382-t890r7xp	323	42	stimulation	stimulation	NN
cord-283382-t890r7xp	323	43	of	of	IN
cord-283382-t890r7xp	323	44	differential	differential	JJ
cord-283382-t890r7xp	323	45	innate	innate	JJ
cord-283382-t890r7xp	323	46	signaling	signal	VBG
cord-283382-t890r7xp	323	47	pathways	pathway	NNS
cord-283382-t890r7xp	323	48	will	will	MD
cord-283382-t890r7xp	323	49	all	all	DT
cord-283382-t890r7xp	323	50	impact	impact	VB
cord-283382-t890r7xp	323	51	on	on	IN
cord-283382-t890r7xp	323	52	their	-PRON-	PRP$
cord-283382-t890r7xp	323	53	downstream	downstream	JJ
cord-283382-t890r7xp	323	54	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	323	55	and	and	CC
cord-283382-t890r7xp	323	56	ability	ability	NN
cord-283382-t890r7xp	323	57	to	to	TO
cord-283382-t890r7xp	323	58	confer	confer	VB
cord-283382-t890r7xp	323	59	protective	protective	JJ
cord-283382-t890r7xp	323	60	efficacy	efficacy	NN
cord-283382-t890r7xp	323	61	.	.	.
cord-283382-t890r7xp	324	1	Unfortunately	unfortunately	RB
cord-283382-t890r7xp	324	2	,	,	,
cord-283382-t890r7xp	324	3	one	one	CD
cord-283382-t890r7xp	324	4	major	major	JJ
cord-283382-t890r7xp	324	5	challenge	challenge	NN
cord-283382-t890r7xp	324	6	in	in	IN
cord-283382-t890r7xp	324	7	performing	perform	VBG
cord-283382-t890r7xp	324	8	these	these	DT
cord-283382-t890r7xp	324	9	types	type	NNS
cord-283382-t890r7xp	324	10	of	of	IN
cord-283382-t890r7xp	324	11	head	head	NN
cord-283382-t890r7xp	324	12	-	-	HYPH
cord-283382-t890r7xp	324	13	to	to	IN
cord-283382-t890r7xp	324	14	-	-	HYPH
cord-283382-t890r7xp	324	15	head	head	NN
cord-283382-t890r7xp	324	16	comparisons	comparison	NNS
cord-283382-t890r7xp	324	17	is	be	VBZ
cord-283382-t890r7xp	324	18	the	the	DT
cord-283382-t890r7xp	324	19	lack	lack	NN
cord-283382-t890r7xp	324	20	of	of	IN
cord-283382-t890r7xp	324	21	widespread	widespread	JJ
cord-283382-t890r7xp	324	22	availability	availability	NN
cord-283382-t890r7xp	324	23	of	of	IN
cord-283382-t890r7xp	324	24	many	many	JJ
cord-283382-t890r7xp	324	25	of	of	IN
cord-283382-t890r7xp	324	26	these	these	DT
cord-283382-t890r7xp	324	27	rare	rare	JJ
cord-283382-t890r7xp	324	28	species	specie	NNS
cord-283382-t890r7xp	324	29	or	or	CC
cord-283382-t890r7xp	324	30	non	non	JJ
cord-283382-t890r7xp	324	31	-	-	JJ
cord-283382-t890r7xp	324	32	human	human	JJ
cord-283382-t890r7xp	324	33	Ad	ad	NN
cord-283382-t890r7xp	324	34	vectors	vector	NNS
cord-283382-t890r7xp	324	35	to	to	IN
cord-283382-t890r7xp	324	36	academic	academic	JJ
cord-283382-t890r7xp	324	37	investigators	investigator	NNS
cord-283382-t890r7xp	324	38	,	,	,
cord-283382-t890r7xp	324	39	as	as	IN
cord-283382-t890r7xp	324	40	many	many	JJ
cord-283382-t890r7xp	324	41	of	of	IN
cord-283382-t890r7xp	324	42	these	these	DT
cord-283382-t890r7xp	324	43	are	be	VBP
cord-283382-t890r7xp	324	44	being	be	VBG
cord-283382-t890r7xp	324	45	developed	develop	VBN
cord-283382-t890r7xp	324	46	by	by	IN
cord-283382-t890r7xp	324	47	large	large	JJ
cord-283382-t890r7xp	324	48	pharmaceutical	pharmaceutical	JJ
cord-283382-t890r7xp	324	49	companies	company	NNS
cord-283382-t890r7xp	324	50	.	.	.
cord-283382-t890r7xp	325	1	It	-PRON-	PRP
cord-283382-t890r7xp	325	2	is	be	VBZ
cord-283382-t890r7xp	325	3	clear	clear	JJ
cord-283382-t890r7xp	325	4	that	that	IN
cord-283382-t890r7xp	325	5	a	a	DT
cord-283382-t890r7xp	325	6	hierarchy	hierarchy	NN
cord-283382-t890r7xp	325	7	exists	exist	VBZ
cord-283382-t890r7xp	325	8	in	in	IN
cord-283382-t890r7xp	325	9	the	the	DT
cord-283382-t890r7xp	325	10	immunological	immunological	JJ
cord-283382-t890r7xp	325	11	potency	potency	NN
cord-283382-t890r7xp	325	12	observed	observe	VBN
cord-283382-t890r7xp	325	13	between	between	IN
cord-283382-t890r7xp	325	14	rare	rare	JJ
cord-283382-t890r7xp	325	15	species	specie	NNS
cord-283382-t890r7xp	325	16	human	human	JJ
cord-283382-t890r7xp	325	17	and	and	CC
cord-283382-t890r7xp	325	18	non	non	JJ
cord-283382-t890r7xp	325	19	-	-	JJ
cord-283382-t890r7xp	325	20	human	human	JJ
cord-283382-t890r7xp	325	21	Ad	ad	NN
cord-283382-t890r7xp	325	22	vectors	vector	NNS
cord-283382-t890r7xp	325	23	in	in	IN
cord-283382-t890r7xp	325	24	various	various	JJ
cord-283382-t890r7xp	325	25	animal	animal	NN
cord-283382-t890r7xp	325	26	species	specie	NNS
cord-283382-t890r7xp	325	27	.	.	.
cord-283382-t890r7xp	326	1	As	as	IN
cord-283382-t890r7xp	326	2	outlined	outline	VBN
cord-283382-t890r7xp	326	3	above	above	RB
cord-283382-t890r7xp	326	4	,	,	,
cord-283382-t890r7xp	326	5	Ad	ad	NN
cord-283382-t890r7xp	326	6	vector	vector	NN
cord-283382-t890r7xp	326	7	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	326	8	is	be	VBZ
cord-283382-t890r7xp	326	9	most	most	RBS
cord-283382-t890r7xp	326	10	likely	likely	RB
cord-283382-t890r7xp	326	11	dependent	dependent	JJ
cord-283382-t890r7xp	326	12	on	on	IN
cord-283382-t890r7xp	326	13	a	a	DT
cord-283382-t890r7xp	326	14	complex	complex	JJ
cord-283382-t890r7xp	326	15	combination	combination	NN
cord-283382-t890r7xp	326	16	of	of	IN
cord-283382-t890r7xp	326	17	factors	factor	NNS
cord-283382-t890r7xp	326	18	,	,	,
cord-283382-t890r7xp	326	19	rather	rather	RB
cord-283382-t890r7xp	326	20	than	than	IN
cord-283382-t890r7xp	326	21	any	any	DT
cord-283382-t890r7xp	326	22	particular	particular	JJ
cord-283382-t890r7xp	326	23	factor	factor	NN
cord-283382-t890r7xp	326	24	in	in	IN
cord-283382-t890r7xp	326	25	isolation	isolation	NN
cord-283382-t890r7xp	326	26	.	.	.
cord-283382-t890r7xp	327	1	An	an	DT
cord-283382-t890r7xp	327	2	ideal	ideal	JJ
cord-283382-t890r7xp	327	3	Ad	ad	NN
cord-283382-t890r7xp	327	4	vaccine	vaccine	NN
cord-283382-t890r7xp	327	5	platform	platform	NN
cord-283382-t890r7xp	327	6	will	will	MD
cord-283382-t890r7xp	327	7	combine	combine	VB
cord-283382-t890r7xp	327	8	the	the	DT
cord-283382-t890r7xp	327	9	following	follow	VBG
cord-283382-t890r7xp	327	10	attributes	attribute	NNS
cord-283382-t890r7xp	327	11	;	;	,
cord-283382-t890r7xp	327	12	(	(	-LRB-
cord-283382-t890r7xp	327	13	i	i	NN
cord-283382-t890r7xp	327	14	)	)	-RRB-
cord-283382-t890r7xp	327	15	low	low	JJ
cord-283382-t890r7xp	327	16	seroprevalence	seroprevalence	NN
cord-283382-t890r7xp	327	17	in	in	IN
cord-283382-t890r7xp	327	18	humans	human	NNS
cord-283382-t890r7xp	327	19	,	,	,
cord-283382-t890r7xp	327	20	(	(	-LRB-
cord-283382-t890r7xp	327	21	ii	ii	NN
cord-283382-t890r7xp	327	22	)	)	-RRB-
cord-283382-t890r7xp	327	23	robust	robust	JJ
cord-283382-t890r7xp	327	24	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	327	25	with	with	IN
cord-283382-t890r7xp	327	26	potential	potential	NN
cord-283382-t890r7xp	327	27	for	for	IN
cord-283382-t890r7xp	327	28	dose	dose	NN
cord-283382-t890r7xp	327	29	-	-	HYPH
cord-283382-t890r7xp	327	30	sparing	sparing	NN
cord-283382-t890r7xp	327	31	,	,	,
cord-283382-t890r7xp	327	32	and	and	CC
cord-283382-t890r7xp	327	33	(	(	-LRB-
cord-283382-t890r7xp	327	34	iii	iii	NN
cord-283382-t890r7xp	327	35	)	)	-RRB-
cord-283382-t890r7xp	327	36	suitable	suitable	JJ
cord-283382-t890r7xp	327	37	manufacturing	manufacturing	NN
cord-283382-t890r7xp	327	38	characteristics	characteristic	NNS
cord-283382-t890r7xp	327	39	(	(	-LRB-
cord-283382-t890r7xp	327	40	i.e.	i.e.	FW
cord-283382-t890r7xp	327	41	,	,	,
cord-283382-t890r7xp	327	42	growth	growth	NN
cord-283382-t890r7xp	327	43	to	to	IN
cord-283382-t890r7xp	327	44	high	high	JJ
cord-283382-t890r7xp	327	45	titers	titer	NNS
cord-283382-t890r7xp	327	46	,	,	,
cord-283382-t890r7xp	327	47	genome	genome	NN
cord-283382-t890r7xp	327	48	stability	stability	NN
cord-283382-t890r7xp	327	49	)	)	-RRB-
cord-283382-t890r7xp	327	50	.	.	.
cord-283382-t890r7xp	328	1	Better	well	JJR
cord-283382-t890r7xp	328	2	understanding	understanding	NN
cord-283382-t890r7xp	328	3	of	of	IN
cord-283382-t890r7xp	328	4	the	the	DT
cord-283382-t890r7xp	328	5	mechanisms	mechanism	NNS
cord-283382-t890r7xp	328	6	which	which	WDT
cord-283382-t890r7xp	328	7	define	define	VBP
cord-283382-t890r7xp	328	8	effective	effective	JJ
cord-283382-t890r7xp	328	9	vaccines	vaccine	NNS
cord-283382-t890r7xp	328	10	,	,	,
cord-283382-t890r7xp	328	11	will	will	MD
cord-283382-t890r7xp	328	12	enable	enable	VB
cord-283382-t890r7xp	328	13	us	-PRON-	PRP
cord-283382-t890r7xp	328	14	to	to	TO
cord-283382-t890r7xp	328	15	design	design	VB
cord-283382-t890r7xp	328	16	and	and	CC
cord-283382-t890r7xp	328	17	customize	customize	VB
cord-283382-t890r7xp	328	18	improvements	improvement	NNS
cord-283382-t890r7xp	328	19	to	to	IN
cord-283382-t890r7xp	328	20	existing	exist	VBG
cord-283382-t890r7xp	328	21	Ad	ad	NN
cord-283382-t890r7xp	328	22	vaccine	vaccine	NN
cord-283382-t890r7xp	328	23	vectors	vector	NNS
cord-283382-t890r7xp	328	24	,	,	,
cord-283382-t890r7xp	328	25	enhancing	enhance	VBG
cord-283382-t890r7xp	328	26	their	-PRON-	PRP$
cord-283382-t890r7xp	328	27	potential	potential	NN
cord-283382-t890r7xp	328	28	for	for	IN
cord-283382-t890r7xp	328	29	future	future	JJ
cord-283382-t890r7xp	328	30	clinical	clinical	JJ
cord-283382-t890r7xp	328	31	use	use	NN
cord-283382-t890r7xp	328	32	.	.	.
cord-283382-t890r7xp	329	1	LC	LC	NNP
cord-283382-t890r7xp	329	2	:	:	:
cord-283382-t890r7xp	329	3	writing	writing	NN
cord-283382-t890r7xp	329	4	and	and	CC
cord-283382-t890r7xp	329	5	editing	editing	NN
cord-283382-t890r7xp	329	6	-	-	HYPH
cord-283382-t890r7xp	329	7	original	original	JJ
cord-283382-t890r7xp	329	8	and	and	CC
cord-283382-t890r7xp	329	9	final	final	JJ
cord-283382-t890r7xp	329	10	draft	draft	NN
cord-283382-t890r7xp	329	11	.	.	.
cord-283382-t890r7xp	329	12	 	 	_SP
cord-283382-t890r7xp	330	1	Clinical	clinical	JJ
cord-283382-t890r7xp	330	2	assessment	assessment	NN
cord-283382-t890r7xp	330	3	of	of	IN
cord-283382-t890r7xp	330	4	a	a	DT
cord-283382-t890r7xp	330	5	novel	novel	JJ
cord-283382-t890r7xp	330	6	recombinant	recombinant	JJ
cord-283382-t890r7xp	330	7	simian	simian	JJ
cord-283382-t890r7xp	330	8	adenovirus	adenovirus	NN
cord-283382-t890r7xp	330	9	ChAdOx1	ChAdOx1	NNP
cord-283382-t890r7xp	330	10	as	as	IN
cord-283382-t890r7xp	330	11	a	a	DT
cord-283382-t890r7xp	330	12	vectored	vectore	VBN
cord-283382-t890r7xp	330	13	vaccine	vaccine	NN
cord-283382-t890r7xp	330	14	expressing	express	VBG
cord-283382-t890r7xp	331	1	conserved	conserve	VBN
cord-283382-t890r7xp	331	2	Influenza	Influenza	NNP
cord-283382-t890r7xp	331	3	A	A	NNP
cord-283382-t890r7xp	331	4	antigens	antigen	NNS
cord-283382-t890r7xp	331	5	Novel	Novel	NNP
cord-283382-t890r7xp	331	6	adenovirus	adenovirus	NN
cord-283382-t890r7xp	331	7	-	-	HYPH
cord-283382-t890r7xp	331	8	based	base	VBN
cord-283382-t890r7xp	331	9	vaccines	vaccine	NNS
cord-283382-t890r7xp	331	10	induce	induce	VBP
cord-283382-t890r7xp	331	11	broad	broad	JJ
cord-283382-t890r7xp	331	12	and	and	CC
cord-283382-t890r7xp	331	13	sustained	sustain	VBD
cord-283382-t890r7xp	331	14	T	t	NN
cord-283382-t890r7xp	331	15	cell	cell	NN
cord-283382-t890r7xp	331	16	responses	response	NNS
cord-283382-t890r7xp	331	17	to	to	IN
cord-283382-t890r7xp	331	18	HCV	HCV	NNP
cord-283382-t890r7xp	331	19	in	in	IN
cord-283382-t890r7xp	331	20	man	man	NN
cord-283382-t890r7xp	332	1	Heterologous	heterologous	JJ
cord-283382-t890r7xp	332	2	two	two	CD
cord-283382-t890r7xp	332	3	-	-	HYPH
cord-283382-t890r7xp	332	4	dose	dose	NN
cord-283382-t890r7xp	332	5	vaccination	vaccination	NN
cord-283382-t890r7xp	332	6	with	with	IN
cord-283382-t890r7xp	332	7	simian	simian	JJ
cord-283382-t890r7xp	332	8	adenovirus	adenovirus	NN
cord-283382-t890r7xp	332	9	and	and	CC
cord-283382-t890r7xp	332	10	poxvirus	poxvirus	NNP
cord-283382-t890r7xp	332	11	vectors	vector	NNS
cord-283382-t890r7xp	332	12	elicits	elicit	VBZ
cord-283382-t890r7xp	332	13	long	long	RB
cord-283382-t890r7xp	332	14	-	-	HYPH
cord-283382-t890r7xp	332	15	lasting	last	VBG
cord-283382-t890r7xp	332	16	cellular	cellular	JJ
cord-283382-t890r7xp	332	17	immunity	immunity	NN
cord-283382-t890r7xp	332	18	to	to	IN
cord-283382-t890r7xp	332	19	influenza	influenza	NN
cord-283382-t890r7xp	332	20	virus	virus	NN
cord-283382-t890r7xp	332	21	A	a	DT
cord-283382-t890r7xp	332	22	in	in	IN
cord-283382-t890r7xp	332	23	healthy	healthy	JJ
cord-283382-t890r7xp	332	24	adults	adult	NNS
cord-283382-t890r7xp	332	25	Safety	safety	NN
cord-283382-t890r7xp	332	26	and	and	CC
cord-283382-t890r7xp	332	27	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	332	28	of	of	IN
cord-283382-t890r7xp	332	29	novel	novel	JJ
cord-283382-t890r7xp	332	30	respiratory	respiratory	JJ
cord-283382-t890r7xp	332	31	syncytial	syncytial	JJ
cord-283382-t890r7xp	332	32	virus	virus	NN
cord-283382-t890r7xp	332	33	(	(	-LRB-
cord-283382-t890r7xp	332	34	RSV	RSV	NNP
cord-283382-t890r7xp	332	35	)	)	-RRB-
cord-283382-t890r7xp	332	36	vaccines	vaccine	NNS
cord-283382-t890r7xp	332	37	based	base	VBN
cord-283382-t890r7xp	332	38	on	on	IN
cord-283382-t890r7xp	332	39	the	the	DT
cord-283382-t890r7xp	332	40	RSV	RSV	NNP
cord-283382-t890r7xp	332	41	viral	viral	JJ
cord-283382-t890r7xp	332	42	proteins	protein	NNS
cord-283382-t890r7xp	332	43	F	F	NNP
cord-283382-t890r7xp	332	44	,	,	,
cord-283382-t890r7xp	332	45	N	N	NNP
cord-283382-t890r7xp	332	46	and	and	CC
cord-283382-t890r7xp	332	47	M2	M2	NNP
cord-283382-t890r7xp	332	48	-	-	HYPH
cord-283382-t890r7xp	332	49	1	1	CD
cord-283382-t890r7xp	332	50	encoded	encode	VBN
cord-283382-t890r7xp	332	51	by	by	IN
cord-283382-t890r7xp	332	52	simian	simian	JJ
cord-283382-t890r7xp	332	53	adenovirus	adenovirus	NN
cord-283382-t890r7xp	332	54	(	(	-LRB-
cord-283382-t890r7xp	332	55	PanAd3-RSV	PanAd3-RSV	NNP
cord-283382-t890r7xp	332	56	)	)	-RRB-
cord-283382-t890r7xp	332	57	and	and	CC
cord-283382-t890r7xp	332	58	MVA	MVA	NNP
cord-283382-t890r7xp	332	59	(	(	-LRB-
cord-283382-t890r7xp	332	60	MVA	MVA	NNP
cord-283382-t890r7xp	332	61	-	-	HYPH
cord-283382-t890r7xp	332	62	RSV	RSV	NNP
cord-283382-t890r7xp	332	63	)	)	-RRB-
cord-283382-t890r7xp	332	64	;	;	:
cord-283382-t890r7xp	332	65	protocol	protocol	NN
cord-283382-t890r7xp	332	66	for	for	IN
cord-283382-t890r7xp	332	67	an	an	DT
cord-283382-t890r7xp	332	68	open	open	JJ
cord-283382-t890r7xp	332	69	-	-	HYPH
cord-283382-t890r7xp	332	70	label	label	NN
cord-283382-t890r7xp	332	71	,	,	,
cord-283382-t890r7xp	332	72	doseescalation	doseescalation	NN
cord-283382-t890r7xp	332	73	,	,	,
cord-283382-t890r7xp	332	74	single	single	JJ
cord-283382-t890r7xp	332	75	-	-	HYPH
cord-283382-t890r7xp	332	76	centre	centre	NN
cord-283382-t890r7xp	332	77	,	,	,
cord-283382-t890r7xp	332	78	phase	phase	NN
cord-283382-t890r7xp	332	79	.	.	.
cord-283382-t890r7xp	333	1	1	1	CD
cord-283382-t890r7xp	333	2	clinical	clinical	JJ
cord-283382-t890r7xp	333	3	trial	trial	NN
cord-283382-t890r7xp	333	4	in	in	IN
cord-283382-t890r7xp	333	5	healthy	healthy	JJ
cord-283382-t890r7xp	333	6	adults	adult	NNS
cord-283382-t890r7xp	333	7	Vaccine	vaccine	NN
cord-283382-t890r7xp	333	8	vectors	vector	NNS
cord-283382-t890r7xp	333	9	derived	derive	VBN
cord-283382-t890r7xp	333	10	from	from	IN
cord-283382-t890r7xp	333	11	a	a	DT
cord-283382-t890r7xp	333	12	large	large	JJ
cord-283382-t890r7xp	333	13	collection	collection	NN
cord-283382-t890r7xp	333	14	of	of	IN
cord-283382-t890r7xp	333	15	simian	simian	JJ
cord-283382-t890r7xp	333	16	adenoviruses	adenovirus	NNS
cord-283382-t890r7xp	333	17	induce	induce	VBP
cord-283382-t890r7xp	333	18	potent	potent	JJ
cord-283382-t890r7xp	333	19	cellular	cellular	JJ
cord-283382-t890r7xp	333	20	immunity	immunity	NN
cord-283382-t890r7xp	333	21	across	across	IN
cord-283382-t890r7xp	333	22	multiple	multiple	JJ
cord-283382-t890r7xp	333	23	species	specie	NNS
cord-283382-t890r7xp	333	24	Evaluation	evaluation	NN
cord-283382-t890r7xp	333	25	of	of	IN
cord-283382-t890r7xp	333	26	a	a	DT
cord-283382-t890r7xp	333	27	mosaic	mosaic	JJ
cord-283382-t890r7xp	333	28	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	333	29	vaccine	vaccine	NN
cord-283382-t890r7xp	333	30	in	in	IN
cord-283382-t890r7xp	333	31	a	a	DT
cord-283382-t890r7xp	333	32	multicentre	multicentre	NNP
cord-283382-t890r7xp	333	33	,	,	,
cord-283382-t890r7xp	333	34	randomised	randomised	JJ
cord-283382-t890r7xp	333	35	,	,	,
cord-283382-t890r7xp	333	36	double	double	JJ
cord-283382-t890r7xp	333	37	-	-	HYPH
cord-283382-t890r7xp	333	38	blind	blind	JJ
cord-283382-t890r7xp	333	39	,	,	,
cord-283382-t890r7xp	333	40	placebo	placebo	NN
cord-283382-t890r7xp	333	41	-	-	HYPH
cord-283382-t890r7xp	333	42	controlled	control	VBN
cord-283382-t890r7xp	333	43	,	,	,
cord-283382-t890r7xp	333	44	phase	phase	NN
cord-283382-t890r7xp	333	45	1/2a	1/2a	JJ
cord-283382-t890r7xp	333	46	clinical	clinical	JJ
cord-283382-t890r7xp	333	47	trial	trial	NN
cord-283382-t890r7xp	333	48	(	(	-LRB-
cord-283382-t890r7xp	333	49	APPROACH	APPROACH	NNP
cord-283382-t890r7xp	333	50	)	)	-RRB-
cord-283382-t890r7xp	333	51	and	and	CC
cord-283382-t890r7xp	333	52	in	in	IN
cord-283382-t890r7xp	333	53	rhesus	rhesu	NNS
cord-283382-t890r7xp	333	54	monkeys	monkey	NNS
cord-283382-t890r7xp	333	55	(	(	-LRB-
cord-283382-t890r7xp	333	56	NHP	NHP	NNP
cord-283382-t890r7xp	333	57	13	13	CD
cord-283382-t890r7xp	333	58	-	-	SYM
cord-283382-t890r7xp	333	59	19	19	CD
cord-283382-t890r7xp	333	60	)	)	-RRB-
cord-283382-t890r7xp	334	1	A	a	DT
cord-283382-t890r7xp	334	2	monovalent	monovalent	JJ
cord-283382-t890r7xp	334	3	chimpanzee	chimpanzee	NN
cord-283382-t890r7xp	334	4	adenovirus	adenovirus	NN
cord-283382-t890r7xp	334	5	Ebola	Ebola	NNP
cord-283382-t890r7xp	334	6	vaccine	vaccine	NN
cord-283382-t890r7xp	334	7	boosted	boost	VBD
cord-283382-t890r7xp	334	8	with	with	IN
cord-283382-t890r7xp	334	9	MVA	MVA	NNP
cord-283382-t890r7xp	334	10	Comparative	Comparative	NNP
cord-283382-t890r7xp	334	11	analysis	analysis	NN
cord-283382-t890r7xp	334	12	of	of	IN
cord-283382-t890r7xp	334	13	the	the	DT
cord-283382-t890r7xp	334	14	magnitude	magnitude	NN
cord-283382-t890r7xp	334	15	,	,	,
cord-283382-t890r7xp	334	16	quality	quality	NN
cord-283382-t890r7xp	334	17	,	,	,
cord-283382-t890r7xp	334	18	phenotype	phenotype	NN
cord-283382-t890r7xp	334	19	,	,	,
cord-283382-t890r7xp	334	20	and	and	CC
cord-283382-t890r7xp	334	21	protective	protective	JJ
cord-283382-t890r7xp	334	22	capacity	capacity	NN
cord-283382-t890r7xp	334	23	of	of	IN
cord-283382-t890r7xp	334	24	simian	simian	JJ
cord-283382-t890r7xp	334	25	immunodeficiency	immunodeficiency	NN
cord-283382-t890r7xp	334	26	virus	virus	NN
cord-283382-t890r7xp	334	27	gag	gag	NN
cord-283382-t890r7xp	334	28	-	-	HYPH
cord-283382-t890r7xp	334	29	specific	specific	JJ
cord-283382-t890r7xp	334	30	CD8	CD8	NNP
cord-283382-t890r7xp	334	31	+	+	CC
cord-283382-t890r7xp	334	32	T	t	NN
cord-283382-t890r7xp	334	33	cells	cell	NNS
cord-283382-t890r7xp	334	34	following	follow	VBG
cord-283382-t890r7xp	334	35	human-	human-	NN
cord-283382-t890r7xp	334	36	,	,	,
cord-283382-t890r7xp	334	37	simian-	simian-	NN
cord-283382-t890r7xp	334	38	,	,	,
cord-283382-t890r7xp	334	39	and	and	CC
cord-283382-t890r7xp	334	40	chimpanzee	chimpanzee	NN
cord-283382-t890r7xp	334	41	-	-	HYPH
cord-283382-t890r7xp	334	42	derived	derive	VBN
cord-283382-t890r7xp	334	43	recombinant	recombinant	JJ
cord-283382-t890r7xp	334	44	adenoviral	adenoviral	JJ
cord-283382-t890r7xp	334	45	vector	vector	NN
cord-283382-t890r7xp	334	46	immunization	immunization	NN
cord-283382-t890r7xp	334	47	Comparative	comparative	JJ
cord-283382-t890r7xp	334	48	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	334	49	in	in	IN
cord-283382-t890r7xp	334	50	rhesus	rhesu	NNS
cord-283382-t890r7xp	334	51	monkeys	monkey	NNS
cord-283382-t890r7xp	334	52	of	of	IN
cord-283382-t890r7xp	334	53	DNA	dna	NN
cord-283382-t890r7xp	334	54	plasmid	plasmid	NN
cord-283382-t890r7xp	334	55	,	,	,
cord-283382-t890r7xp	334	56	recombinant	recombinant	JJ
cord-283382-t890r7xp	334	57	vaccinia	vaccinia	NN
cord-283382-t890r7xp	334	58	virus	virus	NN
cord-283382-t890r7xp	334	59	,	,	,
cord-283382-t890r7xp	334	60	and	and	CC
cord-283382-t890r7xp	334	61	replication	replication	NN
cord-283382-t890r7xp	334	62	-	-	HYPH
cord-283382-t890r7xp	334	63	defective	defective	JJ
cord-283382-t890r7xp	334	64	adenovirus	adenovirus	NN
cord-283382-t890r7xp	334	65	vectors	vector	NNS
cord-283382-t890r7xp	334	66	expressing	express	VBG
cord-283382-t890r7xp	334	67	a	a	DT
cord-283382-t890r7xp	334	68	human	human	JJ
cord-283382-t890r7xp	334	69	immunodeficiency	immunodeficiency	NN
cord-283382-t890r7xp	334	70	virus	virus	NN
cord-283382-t890r7xp	334	71	type	type	NN
cord-283382-t890r7xp	334	72	1	1	CD
cord-283382-t890r7xp	334	73	gag	gag	NN
cord-283382-t890r7xp	334	74	gene	gene	NN
cord-283382-t890r7xp	334	75	Adenoviruses	adenovirus	NNS
cord-283382-t890r7xp	334	76	as	as	IN
cord-283382-t890r7xp	334	77	vaccine	vaccine	NN
cord-283382-t890r7xp	334	78	vectors	vector	NNS
cord-283382-t890r7xp	334	79	Recombinant	recombinant	JJ
cord-283382-t890r7xp	334	80	adenovirus	adenovirus	NN
cord-283382-t890r7xp	334	81	serotype	serotype	NN
cord-283382-t890r7xp	334	82	26	26	CD
cord-283382-t890r7xp	334	83	(	(	-LRB-
cord-283382-t890r7xp	334	84	Ad26	Ad26	NNP
cord-283382-t890r7xp	334	85	)	)	-RRB-
cord-283382-t890r7xp	334	86	and	and	CC
cord-283382-t890r7xp	334	87	Ad35	Ad35	NNP
cord-283382-t890r7xp	334	88	vaccine	vaccine	NN
cord-283382-t890r7xp	334	89	vectors	vector	NNS
cord-283382-t890r7xp	334	90	bypass	bypass	VBP
cord-283382-t890r7xp	334	91	immunity	immunity	NN
cord-283382-t890r7xp	334	92	to	to	IN
cord-283382-t890r7xp	334	93	Ad5	ad5	CD
cord-283382-t890r7xp	334	94	and	and	CC
cord-283382-t890r7xp	334	95	protect	protect	VB
cord-283382-t890r7xp	334	96	nonhuman	nonhuman	NN
cord-283382-t890r7xp	334	97	primates	primate	NNS
cord-283382-t890r7xp	334	98	against	against	IN
cord-283382-t890r7xp	334	99	Ebolavirus	Ebolavirus	NNP
cord-283382-t890r7xp	334	100	challenge	challenge	NN
cord-283382-t890r7xp	334	101	Replication	replication	NN
cord-283382-t890r7xp	334	102	-	-	HYPH
cord-283382-t890r7xp	334	103	incompetent	incompetent	JJ
cord-283382-t890r7xp	334	104	adenoviral	adenoviral	JJ
cord-283382-t890r7xp	334	105	vaccine	vaccine	NN
cord-283382-t890r7xp	334	106	vector	vector	NN
cord-283382-t890r7xp	335	1	elicits	elicit	VBZ
cord-283382-t890r7xp	335	2	effective	effective	JJ
cord-283382-t890r7xp	335	3	anti	anti	JJ
cord-283382-t890r7xp	335	4	-	-	JJ
cord-283382-t890r7xp	335	5	immunodeficiency	immunodeficiency	JJ
cord-283382-t890r7xp	335	6	-	-	HYPH
cord-283382-t890r7xp	335	7	virus	virus	NN
cord-283382-t890r7xp	335	8	immunity	immunity	NN
cord-283382-t890r7xp	335	9	Molecular	molecular	JJ
cord-283382-t890r7xp	335	10	evolution	evolution	NN
cord-283382-t890r7xp	335	11	of	of	IN
cord-283382-t890r7xp	335	12	human	human	JJ
cord-283382-t890r7xp	335	13	adenoviruses	adenovirus	NNS
cord-283382-t890r7xp	335	14	Overreliance	overreliance	JJ
cord-283382-t890r7xp	335	15	on	on	IN
cord-283382-t890r7xp	335	16	the	the	DT
cord-283382-t890r7xp	335	17	hexon	hexon	NNP
cord-283382-t890r7xp	335	18	gene	gene	NN
cord-283382-t890r7xp	335	19	,	,	,
cord-283382-t890r7xp	335	20	leading	lead	VBG
cord-283382-t890r7xp	335	21	to	to	IN
cord-283382-t890r7xp	335	22	misclassification	misclassification	NN
cord-283382-t890r7xp	335	23	of	of	IN
cord-283382-t890r7xp	335	24	human	human	JJ
cord-283382-t890r7xp	335	25	adenoviruses	adenovirus	NNS
cord-283382-t890r7xp	335	26	Targeting	target	VBG
cord-283382-t890r7xp	335	27	antigen	antigen	NN
cord-283382-t890r7xp	335	28	to	to	IN
cord-283382-t890r7xp	335	29	the	the	DT
cord-283382-t890r7xp	335	30	surface	surface	NN
cord-283382-t890r7xp	335	31	of	of	IN
cord-283382-t890r7xp	335	32	EVs	ev	NNS
cord-283382-t890r7xp	335	33	improves	improve	VBZ
cord-283382-t890r7xp	335	34	the	the	DT
cord-283382-t890r7xp	335	35	in	in	IN
cord-283382-t890r7xp	335	36	vivo	vivo	NN
cord-283382-t890r7xp	335	37	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	335	38	of	of	IN
cord-283382-t890r7xp	335	39	human	human	JJ
cord-283382-t890r7xp	335	40	and	and	CC
cord-283382-t890r7xp	335	41	non	non	JJ
cord-283382-t890r7xp	335	42	-	-	JJ
cord-283382-t890r7xp	335	43	human	human	JJ
cord-283382-t890r7xp	335	44	adenoviral	adenoviral	JJ
cord-283382-t890r7xp	335	45	vaccines	vaccine	NNS
cord-283382-t890r7xp	335	46	in	in	IN
cord-283382-t890r7xp	335	47	mice	mouse	NNS
cord-283382-t890r7xp	336	1	An	an	DT
cord-283382-t890r7xp	336	2	engineered	engineer	VBN
cord-283382-t890r7xp	336	3	virus	virus	NN
cord-283382-t890r7xp	336	4	library	library	NN
cord-283382-t890r7xp	336	5	as	as	IN
cord-283382-t890r7xp	336	6	a	a	DT
cord-283382-t890r7xp	336	7	resource	resource	NN
cord-283382-t890r7xp	336	8	for	for	IN
cord-283382-t890r7xp	336	9	the	the	DT
cord-283382-t890r7xp	336	10	spectrum	spectrum	JJ
cord-283382-t890r7xp	336	11	-	-	HYPH
cord-283382-t890r7xp	336	12	wide	wide	JJ
cord-283382-t890r7xp	336	13	exploration	exploration	NN
cord-283382-t890r7xp	336	14	of	of	IN
cord-283382-t890r7xp	336	15	virus	virus	NN
cord-283382-t890r7xp	336	16	and	and	CC
cord-283382-t890r7xp	336	17	vector	vector	NN
cord-283382-t890r7xp	336	18	diversity	diversity	NN
cord-283382-t890r7xp	336	19	Adenoviruses	adenovirus	NNS
cord-283382-t890r7xp	336	20	:	:	:
cord-283382-t890r7xp	336	21	update	update	VB
cord-283382-t890r7xp	336	22	on	on	IN
cord-283382-t890r7xp	336	23	structure	structure	NN
cord-283382-t890r7xp	336	24	and	and	CC
cord-283382-t890r7xp	336	25	function	function	VB
cord-283382-t890r7xp	336	26	Tropism	tropism	NN
cord-283382-t890r7xp	336	27	-	-	HYPH
cord-283382-t890r7xp	336	28	modification	modification	NN
cord-283382-t890r7xp	336	29	strategies	strategy	NNS
cord-283382-t890r7xp	336	30	for	for	IN
cord-283382-t890r7xp	336	31	targeted	target	VBN
cord-283382-t890r7xp	336	32	gene	gene	NN
cord-283382-t890r7xp	336	33	delivery	delivery	NN
cord-283382-t890r7xp	336	34	using	use	VBG
cord-283382-t890r7xp	336	35	adenoviral	adenoviral	NNP
cord-283382-t890r7xp	336	36	vectors	vector	NNS
cord-283382-t890r7xp	336	37	Novel	Novel	NNP
cord-283382-t890r7xp	336	38	vector	vector	NN
cord-283382-t890r7xp	336	39	construction	construction	NN
cord-283382-t890r7xp	336	40	based	base	VBN
cord-283382-t890r7xp	336	41	on	on	IN
cord-283382-t890r7xp	336	42	alternative	alternative	JJ
cord-283382-t890r7xp	336	43	adenovirus	adenovirus	NN
cord-283382-t890r7xp	336	44	types	type	NNS
cord-283382-t890r7xp	336	45	via	via	IN
cord-283382-t890r7xp	336	46	homologous	homologous	JJ
cord-283382-t890r7xp	336	47	recombination	recombination	NN
cord-283382-t890r7xp	336	48	Generation	generation	NN
cord-283382-t890r7xp	336	49	and	and	CC
cord-283382-t890r7xp	336	50	characterization	characterization	NN
cord-283382-t890r7xp	336	51	of	of	IN
cord-283382-t890r7xp	336	52	a	a	DT
cord-283382-t890r7xp	336	53	novel	novel	JJ
cord-283382-t890r7xp	336	54	candidate	candidate	NN
cord-283382-t890r7xp	336	55	gene	gene	NN
cord-283382-t890r7xp	336	56	therapy	therapy	NN
cord-283382-t890r7xp	336	57	and	and	CC
cord-283382-t890r7xp	336	58	vaccination	vaccination	NN
cord-283382-t890r7xp	336	59	vector	vector	NN
cord-283382-t890r7xp	336	60	based	base	VBN
cord-283382-t890r7xp	336	61	on	on	IN
cord-283382-t890r7xp	336	62	human	human	JJ
cord-283382-t890r7xp	336	63	species	specie	NNS
cord-283382-t890r7xp	336	64	D	d	NN
cord-283382-t890r7xp	336	65	adenovirus	adenovirus	NN
cord-283382-t890r7xp	336	66	type	type	NN
cord-283382-t890r7xp	336	67	56	56	CD
cord-283382-t890r7xp	336	68	Characterization	characterization	NN
cord-283382-t890r7xp	336	69	of	of	IN
cord-283382-t890r7xp	336	70	a	a	DT
cord-283382-t890r7xp	336	71	family	family	NN
cord-283382-t890r7xp	336	72	of	of	IN
cord-283382-t890r7xp	336	73	chimpanzee	chimpanzee	NN
cord-283382-t890r7xp	336	74	adenoviruses	adenovirus	NNS
cord-283382-t890r7xp	336	75	and	and	CC
cord-283382-t890r7xp	336	76	development	development	NN
cord-283382-t890r7xp	336	77	of	of	IN
cord-283382-t890r7xp	336	78	molecular	molecular	JJ
cord-283382-t890r7xp	336	79	clones	clone	NNS
cord-283382-t890r7xp	336	80	for	for	IN
cord-283382-t890r7xp	336	81	gene	gene	NN
cord-283382-t890r7xp	336	82	transfer	transfer	NN
cord-283382-t890r7xp	336	83	vectors	vector	NNS
cord-283382-t890r7xp	336	84	Adenoviral	Adenoviral	NNP
cord-283382-t890r7xp	336	85	producer	producer	NN
cord-283382-t890r7xp	336	86	cells	cell	VBZ
cord-283382-t890r7xp	336	87	Safety	safety	NN
cord-283382-t890r7xp	336	88	and	and	CC
cord-283382-t890r7xp	336	89	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	336	90	of	of	IN
cord-283382-t890r7xp	336	91	an	an	DT
cord-283382-t890r7xp	336	92	oral	oral	JJ
cord-283382-t890r7xp	336	93	,	,	,
cord-283382-t890r7xp	336	94	replicating	replicate	VBG
cord-283382-t890r7xp	336	95	adenovirus	adenovirus	NN
cord-283382-t890r7xp	336	96	serotype	serotype	NN
cord-283382-t890r7xp	336	97	4	4	CD
cord-283382-t890r7xp	336	98	vector	vector	NN
cord-283382-t890r7xp	336	99	vaccine	vaccine	NN
cord-283382-t890r7xp	336	100	for	for	IN
cord-283382-t890r7xp	336	101	H5N1	H5N1	NNP
cord-283382-t890r7xp	336	102	influenza	influenza	NN
cord-283382-t890r7xp	336	103	:	:	:
cord-283382-t890r7xp	336	104	a	a	DT
cord-283382-t890r7xp	336	105	randomised	randomised	JJ
cord-283382-t890r7xp	336	106	,	,	,
cord-283382-t890r7xp	336	107	double	double	JJ
cord-283382-t890r7xp	336	108	-	-	HYPH
cord-283382-t890r7xp	336	109	blind	blind	JJ
cord-283382-t890r7xp	336	110	,	,	,
cord-283382-t890r7xp	336	111	placebo	placebo	NN
cord-283382-t890r7xp	336	112	-	-	HYPH
cord-283382-t890r7xp	336	113	controlled	control	VBN
cord-283382-t890r7xp	336	114	,	,	,
cord-283382-t890r7xp	336	115	phase	phase	NN
cord-283382-t890r7xp	336	116	1	1	CD
cord-283382-t890r7xp	336	117	study	study	NN
cord-283382-t890r7xp	336	118	Efficacy	Efficacy	NNP
cord-283382-t890r7xp	336	119	,	,	,
cord-283382-t890r7xp	336	120	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	336	121	,	,	,
cord-283382-t890r7xp	336	122	and	and	CC
cord-283382-t890r7xp	336	123	safety	safety	NN
cord-283382-t890r7xp	336	124	of	of	IN
cord-283382-t890r7xp	336	125	an	an	DT
cord-283382-t890r7xp	336	126	oral	oral	JJ
cord-283382-t890r7xp	336	127	influenza	influenza	NN
cord-283382-t890r7xp	336	128	vaccine	vaccine	NN
cord-283382-t890r7xp	336	129	:	:	:
cord-283382-t890r7xp	336	130	a	a	DT
cord-283382-t890r7xp	336	131	placebocontrolled	placebocontrolled	JJ
cord-283382-t890r7xp	336	132	and	and	CC
cord-283382-t890r7xp	336	133	active	active	RB
cord-283382-t890r7xp	336	134	-	-	HYPH
cord-283382-t890r7xp	336	135	controlled	control	VBN
cord-283382-t890r7xp	336	136	phase	phase	NN
cord-283382-t890r7xp	336	137	2	2	CD
cord-283382-t890r7xp	336	138	human	human	JJ
cord-283382-t890r7xp	336	139	challenge	challenge	NN
cord-283382-t890r7xp	336	140	study	study	NN
cord-283382-t890r7xp	336	141	Clinical	clinical	JJ
cord-283382-t890r7xp	336	142	advances	advance	NNS
cord-283382-t890r7xp	336	143	in	in	IN
cord-283382-t890r7xp	336	144	viral	viral	RB
cord-283382-t890r7xp	336	145	-	-	HYPH
cord-283382-t890r7xp	336	146	vectored	vectore	VBN
cord-283382-t890r7xp	336	147	influenza	influenza	NN
cord-283382-t890r7xp	336	148	vaccines	vaccine	NNS
cord-283382-t890r7xp	336	149	Vaccination	Vaccination	NNP
cord-283382-t890r7xp	336	150	with	with	IN
cord-283382-t890r7xp	336	151	adenovirus	adenovirus	NN
cord-283382-t890r7xp	336	152	serotypes	serotype	NNS
cord-283382-t890r7xp	336	153	35	35	CD
cord-283382-t890r7xp	336	154	,	,	,
cord-283382-t890r7xp	336	155	26	26	CD
cord-283382-t890r7xp	336	156	,	,	,
cord-283382-t890r7xp	336	157	and	and	CC
cord-283382-t890r7xp	336	158	48	48	CD
cord-283382-t890r7xp	336	159	elicits	elicit	VBZ
cord-283382-t890r7xp	336	160	higher	high	JJR
cord-283382-t890r7xp	336	161	levels	level	NNS
cord-283382-t890r7xp	336	162	of	of	IN
cord-283382-t890r7xp	336	163	innate	innate	JJ
cord-283382-t890r7xp	336	164	cytokine	cytokine	NN
cord-283382-t890r7xp	336	165	responses	response	NNS
cord-283382-t890r7xp	336	166	than	than	IN
cord-283382-t890r7xp	336	167	adenovirus	adenovirus	NN
cord-283382-t890r7xp	336	168	serotype	serotype	NN
cord-283382-t890r7xp	336	169	5	5	CD
cord-283382-t890r7xp	336	170	in	in	IN
cord-283382-t890r7xp	336	171	rhesus	rhesu	NNS
cord-283382-t890r7xp	336	172	monkeys	monkey	NNS
cord-283382-t890r7xp	337	1	A	a	DT
cord-283382-t890r7xp	337	2	novel	novel	JJ
cord-283382-t890r7xp	337	3	chimpanzee	chimpanzee	NN
cord-283382-t890r7xp	337	4	adenovirus	adenovirus	NN
cord-283382-t890r7xp	337	5	vector	vector	NN
cord-283382-t890r7xp	337	6	with	with	IN
cord-283382-t890r7xp	337	7	low	low	JJ
cord-283382-t890r7xp	337	8	human	human	JJ
cord-283382-t890r7xp	337	9	seroprevalence	seroprevalence	NN
cord-283382-t890r7xp	337	10	:	:	:
cord-283382-t890r7xp	337	11	improved	improve	VBN
cord-283382-t890r7xp	337	12	systems	system	NNS
cord-283382-t890r7xp	337	13	for	for	IN
cord-283382-t890r7xp	337	14	vector	vector	NN
cord-283382-t890r7xp	337	15	derivation	derivation	NN
cord-283382-t890r7xp	337	16	and	and	CC
cord-283382-t890r7xp	337	17	comparative	comparative	JJ
cord-283382-t890r7xp	337	18	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	337	19	Ad48	Ad48	.
cord-283382-t890r7xp	338	1	hexon	hexon	NNP
cord-283382-t890r7xp	338	2	hypervariable	hypervariable	NNP
cord-283382-t890r7xp	338	3	region	region	NN
cord-283382-t890r7xp	338	4	substitutions	substitution	NNS
cord-283382-t890r7xp	338	5	lead	lead	VBP
cord-283382-t890r7xp	338	6	to	to	IN
cord-283382-t890r7xp	338	7	toxicity	toxicity	NN
cord-283382-t890r7xp	338	8	and	and	CC
cord-283382-t890r7xp	338	9	increased	increase	VBN
cord-283382-t890r7xp	338	10	inflammatory	inflammatory	JJ
cord-283382-t890r7xp	338	11	responses	response	NNS
cord-283382-t890r7xp	338	12	following	follow	VBG
cord-283382-t890r7xp	338	13	intravenous	intravenous	JJ
cord-283382-t890r7xp	338	14	delivery	delivery	NN
cord-283382-t890r7xp	338	15	Comparative	comparative	JJ
cord-283382-t890r7xp	338	16	seroprevalence	seroprevalence	NN
cord-283382-t890r7xp	338	17	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	338	18	of	of	IN
cord-283382-t890r7xp	338	19	six	six	CD
cord-283382-t890r7xp	338	20	rare	rare	JJ
cord-283382-t890r7xp	338	21	serotype	serotype	NN
cord-283382-t890r7xp	338	22	recombinant	recombinant	JJ
cord-283382-t890r7xp	338	23	adenovirus	adenovirus	NN
cord-283382-t890r7xp	338	24	vaccine	vaccine	NN
cord-283382-t890r7xp	338	25	vectors	vector	NNS
cord-283382-t890r7xp	338	26	from	from	IN
cord-283382-t890r7xp	338	27	subgroups	subgroup	NNS
cord-283382-t890r7xp	338	28	B	B	NNP
cord-283382-t890r7xp	338	29	and	and	CC
cord-283382-t890r7xp	338	30	D	D	NNP
cord-283382-t890r7xp	338	31	A	a	DT
cord-283382-t890r7xp	338	32	review	review	NN
cord-283382-t890r7xp	338	33	of	of	IN
cord-283382-t890r7xp	338	34	65	65	CD
cord-283382-t890r7xp	338	35	years	year	NNS
cord-283382-t890r7xp	338	36	of	of	IN
cord-283382-t890r7xp	338	37	human	human	JJ
cord-283382-t890r7xp	338	38	adenovirus	adenovirus	NN
cord-283382-t890r7xp	338	39	seroprevalence	seroprevalence	NN
cord-283382-t890r7xp	338	40	A	a	DT
cord-283382-t890r7xp	338	41	bovine	bovine	JJ
cord-283382-t890r7xp	338	42	adenoviral	adenoviral	JJ
cord-283382-t890r7xp	338	43	vector	vector	NN
cord-283382-t890r7xp	338	44	-	-	HYPH
cord-283382-t890r7xp	338	45	based	base	VBN
cord-283382-t890r7xp	338	46	H5N1	H5N1	NNP
cord-283382-t890r7xp	338	47	influenza	influenza	NN
cord-283382-t890r7xp	338	48	-vaccine	-vaccine	.
cord-283382-t890r7xp	339	1	provides	provide	VBZ
cord-283382-t890r7xp	339	2	enhanced	enhance	VBN
cord-283382-t890r7xp	339	3	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	339	4	and	and	CC
cord-283382-t890r7xp	339	5	protection	protection	NN
cord-283382-t890r7xp	339	6	at	at	IN
cord-283382-t890r7xp	339	7	a	a	DT
cord-283382-t890r7xp	339	8	significantly	significantly	RB
cord-283382-t890r7xp	339	9	low	low	JJ
cord-283382-t890r7xp	339	10	dose	dose	NN
cord-283382-t890r7xp	339	11	Antigen	Antigen	NNP
cord-283382-t890r7xp	339	12	expression	expression	NN
cord-283382-t890r7xp	340	1	determines	determine	VBZ
cord-283382-t890r7xp	340	2	adenoviral	adenoviral	NNP
cord-283382-t890r7xp	340	3	vaccine	vaccine	NN
cord-283382-t890r7xp	340	4	potency	potency	NN
cord-283382-t890r7xp	340	5	independent	independent	JJ
cord-283382-t890r7xp	340	6	of	of	IN
cord-283382-t890r7xp	340	7	IFN	IFN	NNP
cord-283382-t890r7xp	340	8	and	and	CC
cord-283382-t890r7xp	340	9	STING	STING	NNP
cord-283382-t890r7xp	340	10	signaling	signal	VBG
cord-283382-t890r7xp	340	11	Detailed	detailed	JJ
cord-283382-t890r7xp	340	12	analysis	analysis	NN
cord-283382-t890r7xp	340	13	of	of	IN
cord-283382-t890r7xp	340	14	the	the	DT
cord-283382-t890r7xp	340	15	CD8	CD8	NNP
cord-283382-t890r7xp	340	16	+	+	CC
cord-283382-t890r7xp	340	17	Tcell	Tcell	NNP
cord-283382-t890r7xp	340	18	response	response	NN
cord-283382-t890r7xp	340	19	following	follow	VBG
cord-283382-t890r7xp	340	20	adenovirus	adenovirus	NN
cord-283382-t890r7xp	340	21	vaccination	vaccination	NN
cord-283382-t890r7xp	340	22	CD8	CD8	NNP
cord-283382-t890r7xp	340	23	+	+	CC
cord-283382-t890r7xp	340	24	cellular	cellular	JJ
cord-283382-t890r7xp	340	25	immunity	immunity	NN
cord-283382-t890r7xp	341	1	mediates	mediate	VBZ
cord-283382-t890r7xp	341	2	rAd5	rad5	PRP$
cord-283382-t890r7xp	341	3	vaccine	vaccine	NN
cord-283382-t890r7xp	341	4	protection	protection	NN
cord-283382-t890r7xp	341	5	against	against	IN
cord-283382-t890r7xp	341	6	Ebola	Ebola	NNP
cord-283382-t890r7xp	341	7	virus	virus	NN
cord-283382-t890r7xp	341	8	infection	infection	NN
cord-283382-t890r7xp	341	9	of	of	IN
cord-283382-t890r7xp	341	10	nonhuman	nonhuman	NN
cord-283382-t890r7xp	341	11	primates	primate	NNS
cord-283382-t890r7xp	341	12	Adenoviral	Adenoviral	NNP
cord-283382-t890r7xp	341	13	vectors	vector	NNS
cord-283382-t890r7xp	341	14	persist	persist	VBP
cord-283382-t890r7xp	341	15	in	in	IN
cord-283382-t890r7xp	341	16	vivo	vivo	NN
cord-283382-t890r7xp	341	17	and	and	CC
cord-283382-t890r7xp	341	18	maintain	maintain	VB
cord-283382-t890r7xp	341	19	activated	activate	VBN
cord-283382-t890r7xp	341	20	CD8	CD8	NNP
cord-283382-t890r7xp	341	21	+	+	CC
cord-283382-t890r7xp	341	22	T	T	NNP
cord-283382-t890r7xp	341	23	cells	cell	NNS
cord-283382-t890r7xp	341	24	:	:	:
cord-283382-t890r7xp	341	25	implications	implication	NNS
cord-283382-t890r7xp	341	26	for	for	IN
cord-283382-t890r7xp	341	27	their	-PRON-	PRP$
cord-283382-t890r7xp	341	28	use	use	NN
cord-283382-t890r7xp	341	29	as	as	IN
cord-283382-t890r7xp	341	30	vaccines	vaccine	NNS
cord-283382-t890r7xp	341	31	Chimpanzee	Chimpanzee	NNP
cord-283382-t890r7xp	341	32	adenovirus	adenovirus	NN
cord-283382-t890r7xp	341	33	-	-	:
cord-283382-t890r7xp	341	34	and	and	CC
cord-283382-t890r7xp	341	35	MVA	MVA	NNP
cord-283382-t890r7xp	341	36	-	-	HYPH
cord-283382-t890r7xp	341	37	vectored	vectore	VBN
cord-283382-t890r7xp	341	38	respiratory	respiratory	JJ
cord-283382-t890r7xp	341	39	syncytial	syncytial	JJ
cord-283382-t890r7xp	341	40	virus	virus	NN
cord-283382-t890r7xp	341	41	vaccine	vaccine	NN
cord-283382-t890r7xp	341	42	is	be	VBZ
cord-283382-t890r7xp	341	43	safe	safe	JJ
cord-283382-t890r7xp	341	44	and	and	CC
cord-283382-t890r7xp	341	45	immunogenic	immunogenic	JJ
cord-283382-t890r7xp	341	46	in	in	IN
cord-283382-t890r7xp	341	47	adults	adult	NNS
cord-283382-t890r7xp	341	48	Adenovirus	Adenovirus	NNP
cord-283382-t890r7xp	341	49	-	-	HYPH
cord-283382-t890r7xp	341	50	triggered	trigger	VBN
cord-283382-t890r7xp	341	51	innate	innate	JJ
cord-283382-t890r7xp	341	52	signalling	signal	VBG
cord-283382-t890r7xp	341	53	pathways	pathway	NNS
cord-283382-t890r7xp	341	54	CD8	CD8	NNP
cord-283382-t890r7xp	341	55	+	+	CC
cord-283382-t890r7xp	341	56	T	t	NN
cord-283382-t890r7xp	341	57	-	-	HYPH
cord-283382-t890r7xp	341	58	cell	cell	NN
cord-283382-t890r7xp	341	59	expansion	expansion	NN
cord-283382-t890r7xp	341	60	and	and	CC
cord-283382-t890r7xp	341	61	maintenance	maintenance	NN
cord-283382-t890r7xp	341	62	after	after	IN
cord-283382-t890r7xp	341	63	recombinant	recombinant	JJ
cord-283382-t890r7xp	341	64	adenovirus	adenovirus	NN
cord-283382-t890r7xp	341	65	immunization	immunization	NN
cord-283382-t890r7xp	341	66	rely	rely	VBP
cord-283382-t890r7xp	341	67	upon	upon	IN
cord-283382-t890r7xp	341	68	cooperation	cooperation	NN
cord-283382-t890r7xp	341	69	between	between	IN
cord-283382-t890r7xp	341	70	hematopoietic	hematopoietic	JJ
cord-283382-t890r7xp	341	71	and	and	CC
cord-283382-t890r7xp	341	72	nonhematopoietic	nonhematopoietic	JJ
cord-283382-t890r7xp	341	73	antigen	antigen	NN
cord-283382-t890r7xp	341	74	-	-	HYPH
cord-283382-t890r7xp	341	75	presenting	present	VBG
cord-283382-t890r7xp	341	76	cells	cell	NNS
cord-283382-t890r7xp	342	1	Increased	increase	VBN
cord-283382-t890r7xp	342	2	glucose	glucose	NN
cord-283382-t890r7xp	342	3	disposal	disposal	NN
cord-283382-t890r7xp	342	4	induced	induce	VBN
cord-283382-t890r7xp	342	5	by	by	IN
cord-283382-t890r7xp	342	6	adenovirus	adenovirus	NN
cord-283382-t890r7xp	342	7	-	-	HYPH
cord-283382-t890r7xp	342	8	mediated	mediate	VBN
cord-283382-t890r7xp	342	9	transfer	transfer	NN
cord-283382-t890r7xp	342	10	of	of	IN
cord-283382-t890r7xp	342	11	glucokinase	glucokinase	NN
cord-283382-t890r7xp	342	12	to	to	IN
cord-283382-t890r7xp	342	13	skeletal	skeletal	JJ
cord-283382-t890r7xp	342	14	muscle	muscle	NN
cord-283382-t890r7xp	342	15	in	in	IN
cord-283382-t890r7xp	342	16	vivo	vivo	NNP
cord-283382-t890r7xp	342	17	Longterm	Longterm	NNP
cord-283382-t890r7xp	342	18	humoral	humoral	JJ
cord-283382-t890r7xp	342	19	and	and	CC
cord-283382-t890r7xp	342	20	cellular	cellular	JJ
cord-283382-t890r7xp	342	21	immunity	immunity	NN
cord-283382-t890r7xp	342	22	induced	induce	VBN
cord-283382-t890r7xp	342	23	by	by	IN
cord-283382-t890r7xp	342	24	a	a	DT
cord-283382-t890r7xp	342	25	single	single	JJ
cord-283382-t890r7xp	342	26	immunization	immunization	NN
cord-283382-t890r7xp	342	27	with	with	IN
cord-283382-t890r7xp	342	28	replication	replication	NN
cord-283382-t890r7xp	342	29	-	-	HYPH
cord-283382-t890r7xp	342	30	defective	defective	JJ
cord-283382-t890r7xp	342	31	adenovirus	adenovirus	NN
cord-283382-t890r7xp	342	32	recombinant	recombinant	NN
cord-283382-t890r7xp	342	33	vector	vector	NN
cord-283382-t890r7xp	342	34	Comparative	Comparative	NNP
cord-283382-t890r7xp	342	35	analysis	analysis	NN
cord-283382-t890r7xp	342	36	of	of	IN
cord-283382-t890r7xp	342	37	simian	simian	JJ
cord-283382-t890r7xp	342	38	immunodeficiency	immunodeficiency	NN
cord-283382-t890r7xp	342	39	virus	virus	NN
cord-283382-t890r7xp	342	40	gag	gag	NN
cord-283382-t890r7xp	342	41	-	-	HYPH
cord-283382-t890r7xp	342	42	specific	specific	JJ
cord-283382-t890r7xp	342	43	effector	effector	NN
cord-283382-t890r7xp	342	44	and	and	CC
cord-283382-t890r7xp	342	45	memory	memory	NN
cord-283382-t890r7xp	342	46	CD8	CD8	NNP
cord-283382-t890r7xp	342	47	+	+	CC
cord-283382-t890r7xp	342	48	T	T	NNP
cord-283382-t890r7xp	342	49	cells	cell	NNS
cord-283382-t890r7xp	342	50	induced	induce	VBN
cord-283382-t890r7xp	342	51	by	by	IN
cord-283382-t890r7xp	342	52	different	different	JJ
cord-283382-t890r7xp	342	53	adenovirus	adenovirus	NN
cord-283382-t890r7xp	342	54	vectors	vector	NNS
cord-283382-t890r7xp	342	55	Alternative	alternative	JJ
cord-283382-t890r7xp	342	56	serotype	serotype	NN
cord-283382-t890r7xp	342	57	adenovirus	adenovirus	NN
cord-283382-t890r7xp	342	58	vaccine	vaccine	NN
cord-283382-t890r7xp	342	59	vectors	vector	NNS
cord-283382-t890r7xp	342	60	elicit	elicit	VBP
cord-283382-t890r7xp	342	61	memory	memory	NN
cord-283382-t890r7xp	342	62	T	t	NN
cord-283382-t890r7xp	342	63	cells	cell	NNS
cord-283382-t890r7xp	342	64	with	with	IN
cord-283382-t890r7xp	342	65	enhanced	enhance	VBN
cord-283382-t890r7xp	342	66	anamnestic	anamnestic	JJ
cord-283382-t890r7xp	342	67	capacity	capacity	NN
cord-283382-t890r7xp	342	68	compared	compare	VBN
cord-283382-t890r7xp	342	69	to	to	IN
cord-283382-t890r7xp	342	70	Ad5	Ad5	NNP
cord-283382-t890r7xp	342	71	vectors	vector	NNS
cord-283382-t890r7xp	342	72	Type	type	NN
cord-283382-t890r7xp	343	1	I	-PRON-	PRP
cord-283382-t890r7xp	343	2	IFN	IFN	NNP
cord-283382-t890r7xp	343	3	induced	induce	VBN
cord-283382-t890r7xp	343	4	by	by	IN
cord-283382-t890r7xp	343	5	adenovirus	adenovirus	NN
cord-283382-t890r7xp	343	6	serotypes	serotype	NNS
cord-283382-t890r7xp	343	7	28	28	CD
cord-283382-t890r7xp	343	8	and	and	CC
cord-283382-t890r7xp	343	9	35	35	CD
cord-283382-t890r7xp	344	1	has	have	VBZ
cord-283382-t890r7xp	344	2	multiple	multiple	JJ
cord-283382-t890r7xp	344	3	effects	effect	NNS
cord-283382-t890r7xp	344	4	on	on	IN
cord-283382-t890r7xp	344	5	T	t	NN
cord-283382-t890r7xp	344	6	cell	cell	NN
cord-283382-t890r7xp	344	7	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	344	8	Quality	quality	NN
cord-283382-t890r7xp	344	9	of	of	IN
cord-283382-t890r7xp	344	10	the	the	DT
cord-283382-t890r7xp	344	11	transgenespecific	transgenespecific	NN
cord-283382-t890r7xp	345	1	CD8	CD8	NNP
cord-283382-t890r7xp	345	2	+	+	CC
cord-283382-t890r7xp	345	3	T	T	NNP
cord-283382-t890r7xp	345	4	cell	cell	NN
cord-283382-t890r7xp	345	5	response	response	NN
cord-283382-t890r7xp	345	6	induced	induce	VBN
cord-283382-t890r7xp	345	7	by	by	IN
cord-283382-t890r7xp	345	8	adenoviral	adenoviral	NNP
cord-283382-t890r7xp	345	9	vector	vector	NN
cord-283382-t890r7xp	345	10	immunization	immunization	NN
cord-283382-t890r7xp	345	11	is	be	VBZ
cord-283382-t890r7xp	345	12	critically	critically	RB
cord-283382-t890r7xp	345	13	influenced	influence	VBN
cord-283382-t890r7xp	345	14	by	by	IN
cord-283382-t890r7xp	345	15	virus	virus	NN
cord-283382-t890r7xp	345	16	dose	dose	NN
cord-283382-t890r7xp	345	17	and	and	CC
cord-283382-t890r7xp	345	18	route	route	NN
cord-283382-t890r7xp	345	19	of	of	IN
cord-283382-t890r7xp	345	20	vaccination	vaccination	NN
cord-283382-t890r7xp	345	21	Analysis	Analysis	NNP
cord-283382-t890r7xp	345	22	of	of	IN
cord-283382-t890r7xp	345	23	the	the	DT
cord-283382-t890r7xp	345	24	interaction	interaction	NN
cord-283382-t890r7xp	345	25	between	between	IN
cord-283382-t890r7xp	345	26	RGD	RGD	NNP
cord-283382-t890r7xp	345	27	-	-	HYPH
cord-283382-t890r7xp	345	28	expressing	express	VBG
cord-283382-t890r7xp	345	29	adenovirus	adenovirus	NN
cord-283382-t890r7xp	345	30	type	type	NN
cord-283382-t890r7xp	345	31	5	5	CD
cord-283382-t890r7xp	345	32	fiber	fiber	NN
cord-283382-t890r7xp	345	33	knob	knob	NN
cord-283382-t890r7xp	345	34	domains	domain	NNS
cord-283382-t890r7xp	345	35	and	and	CC
cord-283382-t890r7xp	345	36	alphavbeta3	alphavbeta3	NN
cord-283382-t890r7xp	345	37	integrin	integrin	NN
cord-283382-t890r7xp	345	38	reveals	reveal	VBZ
cord-283382-t890r7xp	345	39	distinct	distinct	JJ
cord-283382-t890r7xp	345	40	binding	bind	VBG
cord-283382-t890r7xp	345	41	profiles	profile	NNS
cord-283382-t890r7xp	345	42	and	and	CC
cord-283382-t890r7xp	345	43	intracellular	intracellular	JJ
cord-283382-t890r7xp	345	44	trafficking	trafficking	NN
cord-283382-t890r7xp	345	45	Integrins	Integrins	NNP
cord-283382-t890r7xp	345	46	alpha	alpha	NN
cord-283382-t890r7xp	345	47	v	v	NN
cord-283382-t890r7xp	345	48	beta	beta	NN
cord-283382-t890r7xp	345	49	3	3	CD
cord-283382-t890r7xp	345	50	and	and	CC
cord-283382-t890r7xp	345	51	alpha	alpha	NN
cord-283382-t890r7xp	345	52	v	v	NN
cord-283382-t890r7xp	345	53	beta	beta	NN
cord-283382-t890r7xp	345	54	5	5	CD
cord-283382-t890r7xp	345	55	promote	promote	VBP
cord-283382-t890r7xp	345	56	adenovirus	adenovirus	NN
cord-283382-t890r7xp	345	57	internalization	internalization	NN
cord-283382-t890r7xp	345	58	but	but	CC
cord-283382-t890r7xp	346	1	not	not	RB
cord-283382-t890r7xp	346	2	virus	virus	NN
cord-283382-t890r7xp	346	3	attachment	attachment	NN
cord-283382-t890r7xp	347	1	A	a	DT
cord-283382-t890r7xp	347	2	direct	direct	JJ
cord-283382-t890r7xp	347	3	and	and	CC
cord-283382-t890r7xp	347	4	versatile	versatile	JJ
cord-283382-t890r7xp	347	5	assay	assay	NN
cord-283382-t890r7xp	347	6	measuring	measure	VBG
cord-283382-t890r7xp	347	7	membrane	membrane	NN
cord-283382-t890r7xp	347	8	penetration	penetration	NN
cord-283382-t890r7xp	347	9	of	of	IN
cord-283382-t890r7xp	347	10	adenovirus	adenovirus	NN
cord-283382-t890r7xp	347	11	in	in	IN
cord-283382-t890r7xp	347	12	single	single	JJ
cord-283382-t890r7xp	347	13	cells	cell	NNS
cord-283382-t890r7xp	347	14	Drifting	drift	VBG
cord-283382-t890r7xp	347	15	motions	motion	NNS
cord-283382-t890r7xp	347	16	of	of	IN
cord-283382-t890r7xp	347	17	the	the	DT
cord-283382-t890r7xp	347	18	adenovirus	adenovirus	NN
cord-283382-t890r7xp	347	19	receptor	receptor	NN
cord-283382-t890r7xp	347	20	CAR	car	NN
cord-283382-t890r7xp	347	21	and	and	CC
cord-283382-t890r7xp	347	22	immobile	immobile	JJ
cord-283382-t890r7xp	347	23	integrins	integrin	NNS
cord-283382-t890r7xp	347	24	initiate	initiate	VBP
cord-283382-t890r7xp	347	25	virus	virus	NN
cord-283382-t890r7xp	347	26	uncoating	uncoating	NN
cord-283382-t890r7xp	347	27	and	and	CC
cord-283382-t890r7xp	347	28	membrane	membrane	NN
cord-283382-t890r7xp	347	29	lytic	lytic	JJ
cord-283382-t890r7xp	347	30	protein	protein	NN
cord-283382-t890r7xp	347	31	exposure	exposure	NN
cord-283382-t890r7xp	348	1	Stepwise	Stepwise	NNP
cord-283382-t890r7xp	348	2	dismantling	dismantle	VBG
cord-283382-t890r7xp	348	3	of	of	IN
cord-283382-t890r7xp	348	4	adenovirus	adenovirus	NN
cord-283382-t890r7xp	348	5	2	2	CD
cord-283382-t890r7xp	348	6	during	during	IN
cord-283382-t890r7xp	348	7	entry	entry	NN
cord-283382-t890r7xp	348	8	into	into	IN
cord-283382-t890r7xp	348	9	cells	cell	NNS
cord-283382-t890r7xp	348	10	Difference	difference	NN
cord-283382-t890r7xp	348	11	imaging	imaging	NN
cord-283382-t890r7xp	348	12	of	of	IN
cord-283382-t890r7xp	348	13	adenovirus	adenovirus	NN
cord-283382-t890r7xp	348	14	:	:	:
cord-283382-t890r7xp	348	15	bridging	bridge	VBG
cord-283382-t890r7xp	348	16	the	the	DT
cord-283382-t890r7xp	348	17	resolution	resolution	NN
cord-283382-t890r7xp	348	18	gap	gap	NN
cord-283382-t890r7xp	348	19	between	between	IN
cord-283382-t890r7xp	348	20	X	x	NN
cord-283382-t890r7xp	348	21	-	-	NN
cord-283382-t890r7xp	348	22	ray	ray	JJ
cord-283382-t890r7xp	348	23	crystallography	crystallography	NN
cord-283382-t890r7xp	348	24	and	and	CC
cord-283382-t890r7xp	348	25	electron	electron	NN
cord-283382-t890r7xp	348	26	microscopy	microscopy	NN
cord-283382-t890r7xp	349	1	A	a	DT
cord-283382-t890r7xp	349	2	capsid	capsid	RB
cord-283382-t890r7xp	349	3	-	-	HYPH
cord-283382-t890r7xp	349	4	encoded	encode	VBN
cord-283382-t890r7xp	349	5	PPxY	ppxy	NN
cord-283382-t890r7xp	349	6	-	-	HYPH
cord-283382-t890r7xp	349	7	motif	motif	NN
cord-283382-t890r7xp	349	8	facilitates	facilitate	VBZ
cord-283382-t890r7xp	349	9	adenovirus	adenovirus	NN
cord-283382-t890r7xp	349	10	entry	entry	NN
cord-283382-t890r7xp	349	11	Spatiotemporal	spatiotemporal	JJ
cord-283382-t890r7xp	349	12	dynamics	dynamic	NNS
cord-283382-t890r7xp	349	13	of	of	IN
cord-283382-t890r7xp	349	14	adenovirus	adenovirus	NN
cord-283382-t890r7xp	349	15	membrane	membrane	NN
cord-283382-t890r7xp	349	16	rupture	rupture	NN
cord-283382-t890r7xp	349	17	and	and	CC
cord-283382-t890r7xp	349	18	endosomal	endosomal	NNP
cord-283382-t890r7xp	349	19	escape	escape	VB
cord-283382-t890r7xp	350	1	Adenovirus	Adenovirus	NNP
cord-283382-t890r7xp	350	2	protein	protein	NN
cord-283382-t890r7xp	350	3	VI	VI	NNP
cord-283382-t890r7xp	350	4	mediates	mediate	VBZ
cord-283382-t890r7xp	350	5	membrane	membrane	NN
cord-283382-t890r7xp	350	6	disruption	disruption	NN
cord-283382-t890r7xp	350	7	following	follow	VBG
cord-283382-t890r7xp	350	8	capsid	capsid	NN
cord-283382-t890r7xp	350	9	disassembly	disassembly	NN
cord-283382-t890r7xp	350	10	Localization	localization	NN
cord-283382-t890r7xp	350	11	of	of	IN
cord-283382-t890r7xp	350	12	regions	region	NNS
cord-283382-t890r7xp	350	13	in	in	IN
cord-283382-t890r7xp	350	14	CD46	CD46	NNP
cord-283382-t890r7xp	350	15	that	that	WDT
cord-283382-t890r7xp	350	16	interact	interact	VBP
cord-283382-t890r7xp	350	17	with	with	IN
cord-283382-t890r7xp	350	18	adenovirus	adenovirus	NN
cord-283382-t890r7xp	351	1	The	the	DT
cord-283382-t890r7xp	351	2	human	human	JJ
cord-283382-t890r7xp	351	3	membrane	membrane	NN
cord-283382-t890r7xp	351	4	cofactor	cofactor	NN
cord-283382-t890r7xp	351	5	CD46	CD46	NNP
cord-283382-t890r7xp	351	6	is	be	VBZ
cord-283382-t890r7xp	351	7	a	a	DT
cord-283382-t890r7xp	351	8	receptor	receptor	NN
cord-283382-t890r7xp	351	9	for	for	IN
cord-283382-t890r7xp	351	10	species	specie	NNS
cord-283382-t890r7xp	351	11	B	B	NNP
cord-283382-t890r7xp	351	12	adenovirus	adenovirus	NN
cord-283382-t890r7xp	351	13	serotype	serotype	NN
cord-283382-t890r7xp	352	1	3	3	LS
cord-283382-t890r7xp	352	2	CD46	CD46	NNP
cord-283382-t890r7xp	352	3	is	be	VBZ
cord-283382-t890r7xp	352	4	a	a	DT
cord-283382-t890r7xp	352	5	cellular	cellular	JJ
cord-283382-t890r7xp	352	6	receptor	receptor	NN
cord-283382-t890r7xp	352	7	for	for	IN
cord-283382-t890r7xp	352	8	group	group	NN
cord-283382-t890r7xp	352	9	B	b	NN
cord-283382-t890r7xp	352	10	adenoviruses	adenovirus	NNS
cord-283382-t890r7xp	353	1	Desmoglein	Desmoglein	NNP
cord-283382-t890r7xp	353	2	2	2	CD
cord-283382-t890r7xp	353	3	is	be	VBZ
cord-283382-t890r7xp	353	4	a	a	DT
cord-283382-t890r7xp	353	5	receptor	receptor	NN
cord-283382-t890r7xp	353	6	for	for	IN
cord-283382-t890r7xp	353	7	adenovirus	adenovirus	NN
cord-283382-t890r7xp	353	8	serotypes	serotype	NNS
cord-283382-t890r7xp	353	9	3	3	CD
cord-283382-t890r7xp	353	10	,	,	,
cord-283382-t890r7xp	353	11	7	7	CD
cord-283382-t890r7xp	353	12	,	,	,
cord-283382-t890r7xp	353	13	11	11	CD
cord-283382-t890r7xp	353	14	and	and	CC
cord-283382-t890r7xp	353	15	14	14	CD
cord-283382-t890r7xp	353	16	Human	human	JJ
cord-283382-t890r7xp	353	17	adenovirus	adenovirus	NN
cord-283382-t890r7xp	353	18	type	type	NN
cord-283382-t890r7xp	353	19	26	26	CD
cord-283382-t890r7xp	353	20	uses	use	VBZ
cord-283382-t890r7xp	353	21	sialic	sialic	JJ
cord-283382-t890r7xp	353	22	acid	acid	NN
cord-283382-t890r7xp	353	23	-	-	HYPH
cord-283382-t890r7xp	353	24	bearing	bear	VBG
cord-283382-t890r7xp	353	25	glycans	glycan	NNS
cord-283382-t890r7xp	353	26	as	as	IN
cord-283382-t890r7xp	353	27	a	a	DT
cord-283382-t890r7xp	353	28	primary	primary	JJ
cord-283382-t890r7xp	353	29	cell	cell	NN
cord-283382-t890r7xp	353	30	entry	entry	NN
cord-283382-t890r7xp	353	31	receptor	receptor	NN
cord-283382-t890r7xp	354	1	The	the	DT
cord-283382-t890r7xp	354	2	interaction	interaction	NN
cord-283382-t890r7xp	354	3	between	between	IN
cord-283382-t890r7xp	354	4	the	the	DT
cord-283382-t890r7xp	354	5	fiber	fiber	NN
cord-283382-t890r7xp	354	6	knob	knob	NN
cord-283382-t890r7xp	354	7	domain	domain	NN
cord-283382-t890r7xp	354	8	and	and	CC
cord-283382-t890r7xp	354	9	the	the	DT
cord-283382-t890r7xp	354	10	cellular	cellular	JJ
cord-283382-t890r7xp	354	11	attachment	attachment	NN
cord-283382-t890r7xp	354	12	receptor	receptor	NN
cord-283382-t890r7xp	354	13	determines	determine	VBZ
cord-283382-t890r7xp	354	14	the	the	DT
cord-283382-t890r7xp	354	15	intracellular	intracellular	JJ
cord-283382-t890r7xp	354	16	trafficking	trafficking	NN
cord-283382-t890r7xp	354	17	route	route	NN
cord-283382-t890r7xp	354	18	of	of	IN
cord-283382-t890r7xp	354	19	adenoviruses	adenovirus	NNS
cord-283382-t890r7xp	354	20	Preferential	preferential	JJ
cord-283382-t890r7xp	354	21	activation	activation	NN
cord-283382-t890r7xp	354	22	of	of	IN
cord-283382-t890r7xp	354	23	Toll	Toll	NNP
cord-283382-t890r7xp	354	24	-	-	HYPH
cord-283382-t890r7xp	354	25	like	like	JJ
cord-283382-t890r7xp	354	26	receptor	receptor	NN
cord-283382-t890r7xp	354	27	nine	nine	CD
cord-283382-t890r7xp	354	28	by	by	IN
cord-283382-t890r7xp	354	29	CD46-utilizing	cd46-utilize	VBG
cord-283382-t890r7xp	354	30	adenoviruses	adenovirus	NNS
cord-283382-t890r7xp	355	1	Key	key	JJ
cord-283382-t890r7xp	355	2	role	role	NN
cord-283382-t890r7xp	355	3	of	of	IN
cord-283382-t890r7xp	355	4	the	the	DT
cord-283382-t890r7xp	355	5	scavenger	scavenger	NN
cord-283382-t890r7xp	355	6	receptor	receptor	NN
cord-283382-t890r7xp	355	7	MARCO	MARCO	NNP
cord-283382-t890r7xp	355	8	in	in	IN
cord-283382-t890r7xp	355	9	mediating	mediate	VBG
cord-283382-t890r7xp	355	10	adenovirus	adenovirus	NN
cord-283382-t890r7xp	355	11	infection	infection	NN
cord-283382-t890r7xp	355	12	and	and	CC
cord-283382-t890r7xp	355	13	subsequent	subsequent	JJ
cord-283382-t890r7xp	355	14	innate	innate	JJ
cord-283382-t890r7xp	355	15	responses	response	NNS
cord-283382-t890r7xp	355	16	of	of	IN
cord-283382-t890r7xp	355	17	macrophages	macrophage	NNS
cord-283382-t890r7xp	355	18	.	.	.
cord-283382-t890r7xp	356	1	mBio	mBio	NNP
cord-283382-t890r7xp	356	2	Analysis	Analysis	NNP
cord-283382-t890r7xp	356	3	of	of	IN
cord-283382-t890r7xp	356	4	adenovirus	adenovirus	NN
cord-283382-t890r7xp	356	5	sequestration	sequestration	NN
cord-283382-t890r7xp	356	6	in	in	IN
cord-283382-t890r7xp	356	7	the	the	DT
cord-283382-t890r7xp	356	8	liver	liver	NN
cord-283382-t890r7xp	356	9	,	,	,
cord-283382-t890r7xp	356	10	transduction	transduction	NN
cord-283382-t890r7xp	356	11	of	of	IN
cord-283382-t890r7xp	356	12	hepatic	hepatic	JJ
cord-283382-t890r7xp	356	13	cells	cell	NNS
cord-283382-t890r7xp	356	14	,	,	,
cord-283382-t890r7xp	356	15	and	and	CC
cord-283382-t890r7xp	356	16	innate	innate	JJ
cord-283382-t890r7xp	356	17	toxicity	toxicity	NN
cord-283382-t890r7xp	356	18	after	after	IN
cord-283382-t890r7xp	356	19	injection	injection	NN
cord-283382-t890r7xp	356	20	of	of	IN
cord-283382-t890r7xp	356	21	fiber	fiber	NN
cord-283382-t890r7xp	356	22	-	-	HYPH
cord-283382-t890r7xp	356	23	modified	modify	VBN
cord-283382-t890r7xp	356	24	vectors	vector	NNS
cord-283382-t890r7xp	356	25	Sequestration	Sequestration	NNP
cord-283382-t890r7xp	356	26	of	of	IN
cord-283382-t890r7xp	356	27	adenoviral	adenoviral	JJ
cord-283382-t890r7xp	356	28	vector	vector	NN
cord-283382-t890r7xp	356	29	by	by	IN
cord-283382-t890r7xp	356	30	Kupffer	Kupffer	NNP
cord-283382-t890r7xp	356	31	cells	cell	NNS
cord-283382-t890r7xp	356	32	leads	lead	VBZ
cord-283382-t890r7xp	356	33	to	to	IN
cord-283382-t890r7xp	356	34	a	a	DT
cord-283382-t890r7xp	356	35	nonlinear	nonlinear	JJ
cord-283382-t890r7xp	356	36	dose	dose	JJ
cord-283382-t890r7xp	356	37	response	response	NN
cord-283382-t890r7xp	356	38	of	of	IN
cord-283382-t890r7xp	356	39	transduction	transduction	NN
cord-283382-t890r7xp	356	40	in	in	IN
cord-283382-t890r7xp	356	41	liver	liver	NN
cord-283382-t890r7xp	356	42	PU.1	PU.1	NNP
cord-283382-t890r7xp	356	43	redirects	redirect	VBZ
cord-283382-t890r7xp	356	44	adenovirus	adenovirus	NN
cord-283382-t890r7xp	356	45	to	to	IN
cord-283382-t890r7xp	356	46	lysosomes	lysosome	NNS
cord-283382-t890r7xp	356	47	in	in	IN
cord-283382-t890r7xp	356	48	alveolar	alveolar	JJ
cord-283382-t890r7xp	356	49	macrophages	macrophage	NNS
cord-283382-t890r7xp	356	50	,	,	.
cord-283382-t890r7xp	357	1	uncoupling	uncoupling	JJ
cord-283382-t890r7xp	357	2	internalization	internalization	NN
cord-283382-t890r7xp	357	3	from	from	IN
cord-283382-t890r7xp	357	4	infection	infection	NN
cord-283382-t890r7xp	357	5	Role	role	NN
cord-283382-t890r7xp	357	6	of	of	IN
cord-283382-t890r7xp	357	7	alveolar	alveolar	JJ
cord-283382-t890r7xp	357	8	macrophages	macrophage	NNS
cord-283382-t890r7xp	357	9	in	in	IN
cord-283382-t890r7xp	357	10	rapid	rapid	JJ
cord-283382-t890r7xp	357	11	elimination	elimination	NN
cord-283382-t890r7xp	357	12	of	of	IN
cord-283382-t890r7xp	357	13	adenovirus	adenovirus	NN
cord-283382-t890r7xp	357	14	vectors	vector	NNS
cord-283382-t890r7xp	357	15	administered	administer	VBN
cord-283382-t890r7xp	357	16	to	to	IN
cord-283382-t890r7xp	357	17	the	the	DT
cord-283382-t890r7xp	357	18	epithelial	epithelial	JJ
cord-283382-t890r7xp	357	19	surface	surface	NN
cord-283382-t890r7xp	357	20	of	of	IN
cord-283382-t890r7xp	357	21	the	the	DT
cord-283382-t890r7xp	357	22	respiratory	respiratory	JJ
cord-283382-t890r7xp	357	23	tract	tract	NN
cord-283382-t890r7xp	357	24	Lung	Lung	NNP
cord-283382-t890r7xp	357	25	macrophage	macrophage	NN
cord-283382-t890r7xp	357	26	scavenger	scavenger	NN
cord-283382-t890r7xp	357	27	receptor	receptor	NN
cord-283382-t890r7xp	357	28	SR	SR	NNP
cord-283382-t890r7xp	357	29	-	-	HYPH
cord-283382-t890r7xp	357	30	A6	A6	NNP
cord-283382-t890r7xp	357	31	(	(	-LRB-
cord-283382-t890r7xp	357	32	MARCO	MARCO	NNP
cord-283382-t890r7xp	357	33	)	)	-RRB-
cord-283382-t890r7xp	357	34	is	be	VBZ
cord-283382-t890r7xp	357	35	an	an	DT
cord-283382-t890r7xp	357	36	adenovirus	adenovirus	NN
cord-283382-t890r7xp	357	37	type	type	NN
cord-283382-t890r7xp	357	38	-	-	HYPH
cord-283382-t890r7xp	357	39	specific	specific	JJ
cord-283382-t890r7xp	357	40	virus	virus	NN
cord-283382-t890r7xp	357	41	entry	entry	NN
cord-283382-t890r7xp	357	42	receptor	receptor	NN
cord-283382-t890r7xp	357	43	Internalization	internalization	NN
cord-283382-t890r7xp	357	44	of	of	IN
cord-283382-t890r7xp	357	45	adenovirus	adenovirus	NN
cord-283382-t890r7xp	357	46	by	by	IN
cord-283382-t890r7xp	357	47	alveolar	alveolar	JJ
cord-283382-t890r7xp	357	48	macrophages	macrophage	NNS
cord-283382-t890r7xp	357	49	initiates	initiate	VBZ
cord-283382-t890r7xp	357	50	early	early	JJ
cord-283382-t890r7xp	357	51	proinflammatory	proinflammatory	JJ
cord-283382-t890r7xp	357	52	signaling	signaling	NN
cord-283382-t890r7xp	357	53	during	during	IN
cord-283382-t890r7xp	357	54	acute	acute	JJ
cord-283382-t890r7xp	357	55	respiratory	respiratory	JJ
cord-283382-t890r7xp	357	56	tract	tract	NN
cord-283382-t890r7xp	357	57	infection	infection	NN
cord-283382-t890r7xp	357	58	Rapid	Rapid	NNP
cord-283382-t890r7xp	357	59	Kupffer	Kupffer	NNP
cord-283382-t890r7xp	357	60	cell	cell	NN
cord-283382-t890r7xp	357	61	death	death	NN
cord-283382-t890r7xp	357	62	after	after	IN
cord-283382-t890r7xp	357	63	intravenous	intravenous	JJ
cord-283382-t890r7xp	357	64	injection	injection	NN
cord-283382-t890r7xp	357	65	of	of	IN
cord-283382-t890r7xp	357	66	adenovirus	adenovirus	NN
cord-283382-t890r7xp	357	67	vectors	vector	NNS
cord-283382-t890r7xp	358	1	A	a	DT
cord-283382-t890r7xp	358	2	hemodynamic	hemodynamic	JJ
cord-283382-t890r7xp	358	3	response	response	NN
cord-283382-t890r7xp	358	4	to	to	IN
cord-283382-t890r7xp	358	5	intravenous	intravenous	JJ
cord-283382-t890r7xp	358	6	adenovirus	adenovirus	NN
cord-283382-t890r7xp	358	7	vector	vector	NN
cord-283382-t890r7xp	358	8	particles	particle	NNS
cord-283382-t890r7xp	358	9	is	be	VBZ
cord-283382-t890r7xp	358	10	caused	cause	VBN
cord-283382-t890r7xp	358	11	by	by	IN
cord-283382-t890r7xp	358	12	systemic	systemic	JJ
cord-283382-t890r7xp	358	13	kupffer	kupffer	NNP
cord-283382-t890r7xp	358	14	cell	cell	NN
cord-283382-t890r7xp	358	15	-	-	HYPH
cord-283382-t890r7xp	358	16	mediated	mediate	VBN
cord-283382-t890r7xp	358	17	activation	activation	NN
cord-283382-t890r7xp	358	18	of	of	IN
cord-283382-t890r7xp	358	19	endothelial	endothelial	JJ
cord-283382-t890r7xp	358	20	cells	cell	NNS
cord-283382-t890r7xp	358	21	Clearance	clearance	NN
cord-283382-t890r7xp	358	22	of	of	IN
cord-283382-t890r7xp	358	23	adenovirus	adenovirus	NN
cord-283382-t890r7xp	358	24	by	by	IN
cord-283382-t890r7xp	358	25	Kupffer	Kupffer	NNP
cord-283382-t890r7xp	358	26	cells	cell	NNS
cord-283382-t890r7xp	358	27	is	be	VBZ
cord-283382-t890r7xp	358	28	mediated	mediate	VBN
cord-283382-t890r7xp	358	29	by	by	IN
cord-283382-t890r7xp	358	30	scavenger	scavenger	NN
cord-283382-t890r7xp	358	31	receptors	receptor	NNS
cord-283382-t890r7xp	358	32	,	,	,
cord-283382-t890r7xp	358	33	natural	natural	JJ
cord-283382-t890r7xp	358	34	antibodies	antibody	NNS
cord-283382-t890r7xp	358	35	,	,	,
cord-283382-t890r7xp	358	36	and	and	CC
cord-283382-t890r7xp	358	37	complement	complement	VB
cord-283382-t890r7xp	358	38	Neutrophils	Neutrophils	NNP
cord-283382-t890r7xp	358	39	interact	interact	VBP
cord-283382-t890r7xp	358	40	with	with	IN
cord-283382-t890r7xp	358	41	adenovirus	adenovirus	NN
cord-283382-t890r7xp	358	42	vectors	vector	NNS
cord-283382-t890r7xp	358	43	via	via	IN
cord-283382-t890r7xp	358	44	Fc	Fc	NNP
cord-283382-t890r7xp	358	45	receptors	receptor	NNS
cord-283382-t890r7xp	358	46	and	and	CC
cord-283382-t890r7xp	358	47	complement	complement	VB
cord-283382-t890r7xp	358	48	receptor	receptor	NN
cord-283382-t890r7xp	358	49	1	1	CD
cord-283382-t890r7xp	358	50	Antiviral	Antiviral	NNP
cord-283382-t890r7xp	358	51	antibodies	antibody	NNS
cord-283382-t890r7xp	358	52	target	target	VBP
cord-283382-t890r7xp	358	53	adenovirus	adenovirus	NN
cord-283382-t890r7xp	358	54	to	to	IN
cord-283382-t890r7xp	358	55	phagolysosomes	phagolysosome	NNS
cord-283382-t890r7xp	358	56	and	and	CC
cord-283382-t890r7xp	358	57	amplify	amplify	VB
cord-283382-t890r7xp	358	58	the	the	DT
cord-283382-t890r7xp	358	59	innate	innate	JJ
cord-283382-t890r7xp	358	60	immune	immune	JJ
cord-283382-t890r7xp	358	61	response	response	NN
cord-283382-t890r7xp	358	62	Scavenger	Scavenger	NNP
cord-283382-t890r7xp	358	63	receptor	receptor	NN
cord-283382-t890r7xp	358	64	A	A	NNP
cord-283382-t890r7xp	358	65	:	:	:
cord-283382-t890r7xp	358	66	a	a	DT
cord-283382-t890r7xp	358	67	new	new	JJ
cord-283382-t890r7xp	358	68	route	route	NN
cord-283382-t890r7xp	358	69	for	for	IN
cord-283382-t890r7xp	358	70	adenovirus	adenovirus	NN
cord-283382-t890r7xp	358	71	5	5	CD
cord-283382-t890r7xp	358	72	Scavenger	Scavenger	NNP
cord-283382-t890r7xp	358	73	receptors	receptor	NNS
cord-283382-t890r7xp	358	74	in	in	IN
cord-283382-t890r7xp	358	75	homeostasis	homeostasis	NN
cord-283382-t890r7xp	358	76	and	and	CC
cord-283382-t890r7xp	358	77	immunity	immunity	NN
cord-283382-t890r7xp	358	78	Identification	identification	NN
cord-283382-t890r7xp	358	79	of	of	IN
cord-283382-t890r7xp	358	80	adenovirus	adenovirus	NN
cord-283382-t890r7xp	358	81	serotype	serotype	NN
cord-283382-t890r7xp	358	82	5	5	CD
cord-283382-t890r7xp	358	83	hexon	hexon	NN
cord-283382-t890r7xp	358	84	regions	region	NNS
cord-283382-t890r7xp	358	85	that	that	WDT
cord-283382-t890r7xp	358	86	interact	interact	VBP
cord-283382-t890r7xp	358	87	with	with	IN
cord-283382-t890r7xp	358	88	scavenger	scavenger	NN
cord-283382-t890r7xp	358	89	receptors	receptor	NNS
cord-283382-t890r7xp	358	90	Virus	Virus	NNP
cord-283382-t890r7xp	358	91	binding	bind	VBG
cord-283382-t890r7xp	358	92	to	to	IN
cord-283382-t890r7xp	358	93	a	a	DT
cord-283382-t890r7xp	358	94	plasma	plasma	NN
cord-283382-t890r7xp	358	95	membrane	membrane	NN
cord-283382-t890r7xp	358	96	receptor	receptor	NN
cord-283382-t890r7xp	358	97	triggers	trigger	VBZ
cord-283382-t890r7xp	358	98	interleukin-1	interleukin-1	NNP
cord-283382-t890r7xp	358	99	alpha	alpha	NN
cord-283382-t890r7xp	358	100	-	-	HYPH
cord-283382-t890r7xp	358	101	mediated	mediate	VBN
cord-283382-t890r7xp	358	102	proinflammatory	proinflammatory	JJ
cord-283382-t890r7xp	358	103	macrophage	macrophage	NN
cord-283382-t890r7xp	358	104	response	response	NN
cord-283382-t890r7xp	358	105	in	in	IN
cord-283382-t890r7xp	358	106	vivo	vivo	NNP
cord-283382-t890r7xp	358	107	Blood	blood	NN
cord-283382-t890r7xp	358	108	clearance	clearance	NN
cord-283382-t890r7xp	358	109	rates	rate	NNS
cord-283382-t890r7xp	358	110	of	of	IN
cord-283382-t890r7xp	358	111	adenovirus	adenovirus	NN
cord-283382-t890r7xp	358	112	type	type	NN
cord-283382-t890r7xp	358	113	5	5	CD
cord-283382-t890r7xp	358	114	in	in	IN
cord-283382-t890r7xp	358	115	mice	mouse	NNS
cord-283382-t890r7xp	358	116	Hepatic	hepatic	JJ
cord-283382-t890r7xp	358	117	uptake	uptake	NN
cord-283382-t890r7xp	358	118	of	of	IN
cord-283382-t890r7xp	358	119	negatively	negatively	RB
cord-283382-t890r7xp	358	120	charged	charge	VBN
cord-283382-t890r7xp	358	121	particles	particle	NNS
cord-283382-t890r7xp	358	122	in	in	IN
cord-283382-t890r7xp	358	123	rats	rat	NNS
cord-283382-t890r7xp	358	124	:	:	:
cord-283382-t890r7xp	358	125	possible	possible	JJ
cord-283382-t890r7xp	358	126	involvement	involvement	NN
cord-283382-t890r7xp	358	127	of	of	IN
cord-283382-t890r7xp	358	128	serum	serum	NN
cord-283382-t890r7xp	358	129	proteins	protein	NNS
cord-283382-t890r7xp	358	130	in	in	IN
cord-283382-t890r7xp	358	131	recognition	recognition	NN
cord-283382-t890r7xp	358	132	by	by	IN
cord-283382-t890r7xp	358	133	scavenger	scavenger	NN
cord-283382-t890r7xp	358	134	receptor	receptor	NN
cord-283382-t890r7xp	358	135	Dendritic	Dendritic	NNP
cord-283382-t890r7xp	358	136	cells	cell	NNS
cord-283382-t890r7xp	358	137	cross	cross	VBP
cord-283382-t890r7xp	358	138	-	-	JJ
cord-283382-t890r7xp	358	139	dressed	dressed	JJ
cord-283382-t890r7xp	358	140	with	with	IN
cord-283382-t890r7xp	358	141	peptide	peptide	NN
cord-283382-t890r7xp	358	142	MHC	MHC	NNP
cord-283382-t890r7xp	358	143	class	class	NN
cord-283382-t890r7xp	359	1	I	-PRON-	PRP
cord-283382-t890r7xp	359	2	complexes	complex	NNS
cord-283382-t890r7xp	360	1	prime	prime	NNP
cord-283382-t890r7xp	360	2	CD8	CD8	NNP
cord-283382-t890r7xp	360	3	+	+	CC
cord-283382-t890r7xp	360	4	T	T	NNP
cord-283382-t890r7xp	360	5	cells	cell	NNS
cord-283382-t890r7xp	361	1	Indirect	indirect	JJ
cord-283382-t890r7xp	361	2	activation	activation	NN
cord-283382-t890r7xp	361	3	of	of	IN
cord-283382-t890r7xp	361	4	naive	naive	JJ
cord-283382-t890r7xp	361	5	CD4	CD4	NNP
cord-283382-t890r7xp	361	6	+	+	CC
cord-283382-t890r7xp	361	7	T	t	NN
cord-283382-t890r7xp	361	8	cells	cell	NNS
cord-283382-t890r7xp	361	9	by	by	IN
cord-283382-t890r7xp	361	10	dendritic	dendritic	JJ
cord-283382-t890r7xp	361	11	cell	cell	NN
cord-283382-t890r7xp	361	12	-	-	HYPH
cord-283382-t890r7xp	361	13	derived	derive	VBN
cord-283382-t890r7xp	361	14	exosomes	exosome	NNS
cord-283382-t890r7xp	361	15	Membrane	membrane	NN
cord-283382-t890r7xp	361	16	vesicles	vesicle	NNS
cord-283382-t890r7xp	361	17	as	as	IN
cord-283382-t890r7xp	361	18	conveyors	conveyor	NNS
cord-283382-t890r7xp	361	19	of	of	IN
cord-283382-t890r7xp	361	20	immune	immune	JJ
cord-283382-t890r7xp	361	21	responses	response	NNS
cord-283382-t890r7xp	361	22	Follicular	follicular	JJ
cord-283382-t890r7xp	361	23	dendritic	dendritic	JJ
cord-283382-t890r7xp	361	24	cells	cell	NNS
cord-283382-t890r7xp	361	25	carry	carry	VBP
cord-283382-t890r7xp	361	26	MHC	MHC	NNP
cord-283382-t890r7xp	361	27	class	class	NN
cord-283382-t890r7xp	361	28	II	II	NNP
cord-283382-t890r7xp	361	29	-	-	HYPH
cord-283382-t890r7xp	361	30	expressing	express	VBG
cord-283382-t890r7xp	361	31	microvesicles	microvesicle	NNS
cord-283382-t890r7xp	361	32	at	at	IN
cord-283382-t890r7xp	361	33	their	-PRON-	PRP$
cord-283382-t890r7xp	361	34	surface	surface	NN
cord-283382-t890r7xp	361	35	CD8	CD8	NNS
cord-283382-t890r7xp	361	36	+	+	CC
cord-283382-t890r7xp	361	37	dendritic	dendritic	JJ
cord-283382-t890r7xp	361	38	cells	cell	NNS
cord-283382-t890r7xp	361	39	use	use	VBP
cord-283382-t890r7xp	361	40	LFA-1	LFA-1	NNP
cord-283382-t890r7xp	361	41	to	to	TO
cord-283382-t890r7xp	361	42	capture	capture	VB
cord-283382-t890r7xp	361	43	MHC	MHC	NNP
cord-283382-t890r7xp	361	44	-	-	HYPH
cord-283382-t890r7xp	361	45	peptide	peptide	NN
cord-283382-t890r7xp	361	46	complexes	complex	NNS
cord-283382-t890r7xp	361	47	from	from	IN
cord-283382-t890r7xp	361	48	exosomes	exosome	NNS
cord-283382-t890r7xp	361	49	in	in	IN
cord-283382-t890r7xp	361	50	vivo	vivo	NNP
cord-283382-t890r7xp	361	51	Immunology	Immunology	NNP
cord-283382-t890r7xp	362	1	:	:	:
cord-283382-t890r7xp	362	2	cross	cross	NN
cord-283382-t890r7xp	362	3	-	-	NNS
cord-283382-t890r7xp	362	4	dressers	dresser	NNS
cord-283382-t890r7xp	362	5	turn	turn	VB
cord-283382-t890r7xp	362	6	on	on	RP
cord-283382-t890r7xp	362	7	T	t	NN
cord-283382-t890r7xp	362	8	cells	cell	NNS
cord-283382-t890r7xp	362	9	CD8	CD8	NNP
cord-283382-t890r7xp	362	10	+	+	CC
cord-283382-t890r7xp	362	11	T	t	NN
cord-283382-t890r7xp	362	12	cell	cell	NN
cord-283382-t890r7xp	362	13	responses	response	NNS
cord-283382-t890r7xp	362	14	following	follow	VBG
cord-283382-t890r7xp	362	15	replication	replication	NN
cord-283382-t890r7xp	362	16	-	-	HYPH
cord-283382-t890r7xp	362	17	defective	defective	JJ
cord-283382-t890r7xp	362	18	adenovirus	adenovirus	NN
cord-283382-t890r7xp	362	19	serotype	serotype	NN
cord-283382-t890r7xp	362	20	5	5	CD
cord-283382-t890r7xp	362	21	immunization	immunization	NN
cord-283382-t890r7xp	363	1	are	be	VBP
cord-283382-t890r7xp	363	2	dependent	dependent	JJ
cord-283382-t890r7xp	363	3	on	on	IN
cord-283382-t890r7xp	363	4	CD11c+	CD11c+	NNP
cord-283382-t890r7xp	363	5	dendritic	dendritic	JJ
cord-283382-t890r7xp	363	6	cells	cell	NNS
cord-283382-t890r7xp	363	7	but	but	CC
cord-283382-t890r7xp	363	8	show	show	VBP
cord-283382-t890r7xp	363	9	redundancy	redundancy	NN
cord-283382-t890r7xp	363	10	in	in	IN
cord-283382-t890r7xp	363	11	their	-PRON-	PRP$
cord-283382-t890r7xp	363	12	requirement	requirement	NN
cord-283382-t890r7xp	363	13	of	of	IN
cord-283382-t890r7xp	363	14	TLR	TLR	NNP
cord-283382-t890r7xp	363	15	and	and	CC
cord-283382-t890r7xp	363	16	nucleotidebinding	nucleotidebinde	VBG
cord-283382-t890r7xp	363	17	oligomerization	oligomerization	NN
cord-283382-t890r7xp	363	18	domain	domain	NN
cord-283382-t890r7xp	363	19	-	-	HYPH
cord-283382-t890r7xp	363	20	like	like	JJ
cord-283382-t890r7xp	363	21	receptor	receptor	NN
cord-283382-t890r7xp	363	22	signaling	signal	VBG
cord-283382-t890r7xp	363	23	Distinct	distinct	JJ
cord-283382-t890r7xp	363	24	roles	role	NNS
cord-283382-t890r7xp	363	25	of	of	IN
cord-283382-t890r7xp	363	26	adenovirus	adenovirus	NN
cord-283382-t890r7xp	363	27	vector	vector	NN
cord-283382-t890r7xp	363	28	-	-	HYPH
cord-283382-t890r7xp	363	29	transduced	transduce	VBN
cord-283382-t890r7xp	363	30	dendritic	dendritic	JJ
cord-283382-t890r7xp	363	31	cells	cell	NNS
cord-283382-t890r7xp	363	32	,	,	,
cord-283382-t890r7xp	363	33	myoblasts	myoblast	NNS
cord-283382-t890r7xp	363	34	,	,	,
cord-283382-t890r7xp	363	35	and	and	CC
cord-283382-t890r7xp	363	36	endothelial	endothelial	JJ
cord-283382-t890r7xp	363	37	cells	cell	NNS
cord-283382-t890r7xp	363	38	in	in	IN
cord-283382-t890r7xp	363	39	mediating	mediate	VBG
cord-283382-t890r7xp	363	40	an	an	DT
cord-283382-t890r7xp	363	41	immune	immune	JJ
cord-283382-t890r7xp	363	42	response	response	NN
cord-283382-t890r7xp	363	43	against	against	IN
cord-283382-t890r7xp	363	44	a	a	DT
cord-283382-t890r7xp	363	45	transgene	transgene	NN
cord-283382-t890r7xp	363	46	product	product	NN
cord-283382-t890r7xp	363	47	Effect	effect	NN
cord-283382-t890r7xp	363	48	of	of	IN
cord-283382-t890r7xp	363	49	adenovirus	adenovirus	NN
cord-283382-t890r7xp	363	50	gene	gene	NN
cord-283382-t890r7xp	363	51	transfer	transfer	NN
cord-283382-t890r7xp	363	52	vectors	vector	NNS
cord-283382-t890r7xp	363	53	on	on	IN
cord-283382-t890r7xp	363	54	the	the	DT
cord-283382-t890r7xp	363	55	immunologic	immunologic	JJ
cord-283382-t890r7xp	363	56	functions	function	NNS
cord-283382-t890r7xp	363	57	of	of	IN
cord-283382-t890r7xp	363	58	mouse	mouse	NN
cord-283382-t890r7xp	363	59	dendritic	dendritic	JJ
cord-283382-t890r7xp	363	60	cells	cell	NNS
cord-283382-t890r7xp	363	61	Recombinant	recombinant	JJ
cord-283382-t890r7xp	363	62	adenovirus	adenovirus	NN
cord-283382-t890r7xp	363	63	induces	induce	VBZ
cord-283382-t890r7xp	363	64	maturation	maturation	NN
cord-283382-t890r7xp	363	65	of	of	IN
cord-283382-t890r7xp	363	66	dendritic	dendritic	JJ
cord-283382-t890r7xp	363	67	cells	cell	NNS
cord-283382-t890r7xp	363	68	via	via	IN
cord-283382-t890r7xp	363	69	an	an	DT
cord-283382-t890r7xp	363	70	NF	nf	NN
cord-283382-t890r7xp	363	71	-	-	HYPH
cord-283382-t890r7xp	363	72	kappaB	kappaB	NNP
cord-283382-t890r7xp	363	73	-	-	HYPH
cord-283382-t890r7xp	363	74	dependent	dependent	JJ
cord-283382-t890r7xp	363	75	pathway	pathway	NN
cord-283382-t890r7xp	363	76	The	the	DT
cord-283382-t890r7xp	363	77	maturation	maturation	NN
cord-283382-t890r7xp	363	78	of	of	IN
cord-283382-t890r7xp	363	79	murine	murine	JJ
cord-283382-t890r7xp	363	80	dendritic	dendritic	JJ
cord-283382-t890r7xp	363	81	cells	cell	NNS
cord-283382-t890r7xp	363	82	induced	induce	VBN
cord-283382-t890r7xp	363	83	by	by	IN
cord-283382-t890r7xp	363	84	human	human	JJ
cord-283382-t890r7xp	363	85	adenovirus	adenovirus	NN
cord-283382-t890r7xp	363	86	is	be	VBZ
cord-283382-t890r7xp	363	87	mediated	mediate	VBN
cord-283382-t890r7xp	363	88	by	by	IN
cord-283382-t890r7xp	363	89	the	the	DT
cord-283382-t890r7xp	363	90	fiber	fiber	NN
cord-283382-t890r7xp	363	91	knob	knob	NN
cord-283382-t890r7xp	363	92	domain	domain	NN
cord-283382-t890r7xp	363	93	Efficient	efficient	JJ
cord-283382-t890r7xp	363	94	targeting	targeting	NN
cord-283382-t890r7xp	363	95	of	of	IN
cord-283382-t890r7xp	363	96	protein	protein	NN
cord-283382-t890r7xp	363	97	antigen	antigen	NN
cord-283382-t890r7xp	363	98	to	to	IN
cord-283382-t890r7xp	363	99	the	the	DT
cord-283382-t890r7xp	363	100	dendritic	dendritic	JJ
cord-283382-t890r7xp	363	101	cell	cell	NN
cord-283382-t890r7xp	363	102	receptor	receptor	NN
cord-283382-t890r7xp	363	103	DEC-205	DEC-205	NNP
cord-283382-t890r7xp	363	104	in	in	IN
cord-283382-t890r7xp	363	105	the	the	DT
cord-283382-t890r7xp	363	106	steady	steady	JJ
cord-283382-t890r7xp	363	107	state	state	NN
cord-283382-t890r7xp	363	108	leads	lead	VBZ
cord-283382-t890r7xp	363	109	to	to	IN
cord-283382-t890r7xp	363	110	antigen	antigen	NN
cord-283382-t890r7xp	363	111	presentation	presentation	NN
cord-283382-t890r7xp	363	112	on	on	IN
cord-283382-t890r7xp	363	113	major	major	JJ
cord-283382-t890r7xp	363	114	histocompatibility	histocompatibility	NN
cord-283382-t890r7xp	363	115	complex	complex	JJ
cord-283382-t890r7xp	363	116	class	class	NN
cord-283382-t890r7xp	363	117	I	-PRON-	PRP
cord-283382-t890r7xp	363	118	products	product	NNS
cord-283382-t890r7xp	363	119	and	and	CC
cord-283382-t890r7xp	363	120	peripheral	peripheral	JJ
cord-283382-t890r7xp	363	121	CD8	CD8	NNP
cord-283382-t890r7xp	363	122	+	+	CC
cord-283382-t890r7xp	363	123	T	T	NNP
cord-283382-t890r7xp	363	124	cell	cell	NN
cord-283382-t890r7xp	363	125	tolerance	tolerance	NN
cord-283382-t890r7xp	363	126	Inhibition	inhibition	NN
cord-283382-t890r7xp	363	127	of	of	IN
cord-283382-t890r7xp	363	128	melanoma	melanoma	NN
cord-283382-t890r7xp	363	129	growth	growth	NN
cord-283382-t890r7xp	363	130	by	by	IN
cord-283382-t890r7xp	363	131	targeting	target	VBG
cord-283382-t890r7xp	363	132	of	of	IN
cord-283382-t890r7xp	363	133	antigen	antigen	NN
cord-283382-t890r7xp	363	134	to	to	IN
cord-283382-t890r7xp	363	135	dendritic	dendritic	JJ
cord-283382-t890r7xp	363	136	cells	cell	NNS
cord-283382-t890r7xp	363	137	via	via	IN
cord-283382-t890r7xp	363	138	an	an	DT
cord-283382-t890r7xp	363	139	anti	anti	JJ
cord-283382-t890r7xp	363	140	-	-	JJ
cord-283382-t890r7xp	363	141	DEC-205	dec-205	JJ
cord-283382-t890r7xp	363	142	single	single	JJ
cord-283382-t890r7xp	363	143	-	-	HYPH
cord-283382-t890r7xp	363	144	chain	chain	NN
cord-283382-t890r7xp	363	145	fragment	fragment	NN
cord-283382-t890r7xp	363	146	variable	variable	NN
cord-283382-t890r7xp	363	147	molecule	molecule	NN
cord-283382-t890r7xp	363	148	Enhanced	enhance	VBN
cord-283382-t890r7xp	363	149	gene	gene	NN
cord-283382-t890r7xp	363	150	transfer	transfer	NN
cord-283382-t890r7xp	363	151	to	to	IN
cord-283382-t890r7xp	363	152	mouse	mouse	NN
cord-283382-t890r7xp	363	153	dendritic	dendritic	JJ
cord-283382-t890r7xp	363	154	cells	cell	NNS
cord-283382-t890r7xp	363	155	using	use	VBG
cord-283382-t890r7xp	363	156	adenoviral	adenoviral	NNP
cord-283382-t890r7xp	363	157	vectors	vector	NNS
cord-283382-t890r7xp	363	158	coated	coat	VBN
cord-283382-t890r7xp	363	159	with	with	IN
cord-283382-t890r7xp	363	160	a	a	DT
cord-283382-t890r7xp	363	161	novel	novel	JJ
cord-283382-t890r7xp	363	162	adapter	adapter	NN
cord-283382-t890r7xp	363	163	molecule	molecule	NN
cord-283382-t890r7xp	363	164	High	high	JJ
cord-283382-t890r7xp	363	165	efficiency	efficiency	NN
cord-283382-t890r7xp	363	166	transduction	transduction	NN
cord-283382-t890r7xp	363	167	of	of	IN
cord-283382-t890r7xp	363	168	dendritic	dendritic	JJ
cord-283382-t890r7xp	363	169	cells	cell	NNS
cord-283382-t890r7xp	363	170	by	by	IN
cord-283382-t890r7xp	363	171	adenoviral	adenoviral	JJ
cord-283382-t890r7xp	363	172	vectors	vector	NNS
cord-283382-t890r7xp	363	173	targeted	target	VBN
cord-283382-t890r7xp	363	174	to	to	IN
cord-283382-t890r7xp	363	175	DC	DC	NNP
cord-283382-t890r7xp	363	176	-	-	HYPH
cord-283382-t890r7xp	363	177	SIGN	SIGN	NNP
cord-283382-t890r7xp	363	178	Adenovirus	Adenovirus	NNP
cord-283382-t890r7xp	363	179	serotype	serotype	NN
cord-283382-t890r7xp	363	180	5	5	CD
cord-283382-t890r7xp	363	181	infects	infect	VBZ
cord-283382-t890r7xp	363	182	human	human	JJ
cord-283382-t890r7xp	363	183	dendritic	dendritic	JJ
cord-283382-t890r7xp	363	184	cells	cell	NNS
cord-283382-t890r7xp	363	185	via	via	IN
cord-283382-t890r7xp	363	186	a	a	DT
cord-283382-t890r7xp	363	187	coxsackievirus	coxsackievirus	NN
cord-283382-t890r7xp	363	188	-	-	HYPH
cord-283382-t890r7xp	363	189	adenovirus	adenovirus	NN
cord-283382-t890r7xp	363	190	receptor	receptor	NN
cord-283382-t890r7xp	363	191	-	-	HYPH
cord-283382-t890r7xp	363	192	independent	independent	JJ
cord-283382-t890r7xp	363	193	receptor	receptor	NN
cord-283382-t890r7xp	363	194	pathway	pathway	NN
cord-283382-t890r7xp	363	195	mediated	mediate	VBN
cord-283382-t890r7xp	363	196	by	by	IN
cord-283382-t890r7xp	363	197	lactoferrin	lactoferrin	NNP
cord-283382-t890r7xp	363	198	DC	DC	NNP
cord-283382-t890r7xp	363	199	-	-	HYPH
cord-283382-t890r7xp	363	200	SIGN	SIGN	NNP
cord-283382-t890r7xp	363	201	Myeloid	Myeloid	NNP
cord-283382-t890r7xp	363	202	and	and	CC
cord-283382-t890r7xp	363	203	plasmacytoid	plasmacytoid	NN
cord-283382-t890r7xp	363	204	dendritic	dendritic	JJ
cord-283382-t890r7xp	363	205	cells	cell	NNS
cord-283382-t890r7xp	363	206	are	be	VBP
cord-283382-t890r7xp	363	207	susceptible	susceptible	JJ
cord-283382-t890r7xp	363	208	to	to	IN
cord-283382-t890r7xp	363	209	recombinant	recombinant	JJ
cord-283382-t890r7xp	363	210	adenovirus	adenovirus	NN
cord-283382-t890r7xp	363	211	vectors	vector	NNS
cord-283382-t890r7xp	363	212	and	and	CC
cord-283382-t890r7xp	363	213	stimulate	stimulate	VB
cord-283382-t890r7xp	363	214	polyfunctional	polyfunctional	JJ
cord-283382-t890r7xp	363	215	memory	memory	NN
cord-283382-t890r7xp	363	216	T	T	NNP
cord-283382-t890r7xp	363	217	cell	cell	NN
cord-283382-t890r7xp	363	218	responses	response	NNS
cord-283382-t890r7xp	363	219	A	a	DT
cord-283382-t890r7xp	363	220	CD46-binding	cd46-binde	VBG
cord-283382-t890r7xp	363	221	chimpanzee	chimpanzee	NN
cord-283382-t890r7xp	363	222	adenovirus	adenovirus	NN
cord-283382-t890r7xp	363	223	vector	vector	NN
cord-283382-t890r7xp	363	224	as	as	IN
cord-283382-t890r7xp	363	225	a	a	DT
cord-283382-t890r7xp	363	226	vaccine	vaccine	NN
cord-283382-t890r7xp	363	227	carrier	carrier	NN
cord-283382-t890r7xp	363	228	Adenovirus	Adenovirus	NNP
cord-283382-t890r7xp	363	229	serotype	serotype	NN
cord-283382-t890r7xp	363	230	3	3	CD
cord-283382-t890r7xp	363	231	utilizes	utilize	VBZ
cord-283382-t890r7xp	363	232	CD80	CD80	NNP
cord-283382-t890r7xp	363	233	(	(	-LRB-
cord-283382-t890r7xp	363	234	B7.1	B7.1	NNP
cord-283382-t890r7xp	363	235	)	)	-RRB-
cord-283382-t890r7xp	363	236	and	and	CC
cord-283382-t890r7xp	363	237	CD86	CD86	NNP
cord-283382-t890r7xp	363	238	(	(	-LRB-
cord-283382-t890r7xp	363	239	B7.2	B7.2	JJS
cord-283382-t890r7xp	363	240	)	)	-RRB-
cord-283382-t890r7xp	363	241	as	as	IN
cord-283382-t890r7xp	363	242	cellular	cellular	JJ
cord-283382-t890r7xp	363	243	attachment	attachment	NN
cord-283382-t890r7xp	363	244	receptors	receptor	NNS
cord-283382-t890r7xp	363	245	Improved	improve	VBD
cord-283382-t890r7xp	363	246	induction	induction	NN
cord-283382-t890r7xp	363	247	of	of	IN
cord-283382-t890r7xp	363	248	anti	anti	JJ
cord-283382-t890r7xp	363	249	-	-	JJ
cord-283382-t890r7xp	363	250	melanoma	melanoma	JJ
cord-283382-t890r7xp	363	251	t	t	NN
cord-283382-t890r7xp	363	252	cells	cell	NNS
cord-283382-t890r7xp	363	253	by	by	IN
cord-283382-t890r7xp	363	254	adenovirus-5/3	adenovirus-5/3	JJ
cord-283382-t890r7xp	363	255	fiber	fiber	NN
cord-283382-t890r7xp	363	256	modification	modification	NN
cord-283382-t890r7xp	363	257	to	to	TO
cord-283382-t890r7xp	363	258	target	target	VB
cord-283382-t890r7xp	363	259	human	human	JJ
cord-283382-t890r7xp	363	260	DCs	DCs	NNP
cord-283382-t890r7xp	363	261	Incorporation	Incorporation	NNP
cord-283382-t890r7xp	363	262	of	of	IN
cord-283382-t890r7xp	363	263	porcine	porcine	JJ
cord-283382-t890r7xp	363	264	adenovirus	adenovirus	NN
cord-283382-t890r7xp	363	265	4	4	CD
cord-283382-t890r7xp	363	266	fiber	fiber	NN
cord-283382-t890r7xp	363	267	protein	protein	NN
cord-283382-t890r7xp	363	268	enhances	enhance	VBZ
cord-283382-t890r7xp	363	269	infectivity	infectivity	NN
cord-283382-t890r7xp	363	270	of	of	IN
cord-283382-t890r7xp	363	271	adenovirus	adenovirus	NN
cord-283382-t890r7xp	363	272	vector	vector	NN
cord-283382-t890r7xp	363	273	on	on	IN
cord-283382-t890r7xp	363	274	dendritic	dendritic	JJ
cord-283382-t890r7xp	363	275	cells	cell	NNS
cord-283382-t890r7xp	363	276	:	:	:
cord-283382-t890r7xp	363	277	implications	implication	NNS
cord-283382-t890r7xp	363	278	for	for	IN
cord-283382-t890r7xp	363	279	immune	immune	NN
cord-283382-t890r7xp	363	280	-	-	HYPH
cord-283382-t890r7xp	363	281	mediated	mediate	VBN
cord-283382-t890r7xp	363	282	cancer	cancer	NN
cord-283382-t890r7xp	363	283	therapy	therapy	NN
cord-283382-t890r7xp	364	1	In	in	IN
cord-283382-t890r7xp	364	2	vitro	vitro	FW
cord-283382-t890r7xp	364	3	dendritic	dendritic	JJ
cord-283382-t890r7xp	364	4	cell	cell	NN
cord-283382-t890r7xp	364	5	infection	infection	NN
cord-283382-t890r7xp	364	6	by	by	IN
cord-283382-t890r7xp	364	7	pseudotyped	pseudotyped	NNP
cord-283382-t890r7xp	364	8	adenoviral	adenoviral	NNP
cord-283382-t890r7xp	364	9	vectors	vector	NNS
cord-283382-t890r7xp	364	10	does	do	VBZ
cord-283382-t890r7xp	364	11	not	not	RB
cord-283382-t890r7xp	364	12	correlate	correlate	VB
cord-283382-t890r7xp	364	13	with	with	IN
cord-283382-t890r7xp	364	14	their	-PRON-	PRP$
cord-283382-t890r7xp	364	15	in	in	IN
cord-283382-t890r7xp	364	16	vivo	vivo	NN
cord-283382-t890r7xp	364	17	immunogenicity	immunogenicity	IN
cord-283382-t890r7xp	364	18	Chimpanzee	Chimpanzee	NNP
cord-283382-t890r7xp	364	19	adenoviral	adenoviral	JJ
cord-283382-t890r7xp	364	20	vectors	vector	NNS
cord-283382-t890r7xp	364	21	as	as	IN
cord-283382-t890r7xp	364	22	vaccines	vaccine	NNS
cord-283382-t890r7xp	364	23	-challenges	-challenges	,
cord-283382-t890r7xp	364	24	to	to	TO
cord-283382-t890r7xp	364	25	move	move	VB
cord-283382-t890r7xp	364	26	the	the	DT
cord-283382-t890r7xp	364	27	technology	technology	NN
cord-283382-t890r7xp	364	28	into	into	IN
cord-283382-t890r7xp	364	29	the	the	DT
cord-283382-t890r7xp	364	30	fast	fast	JJ
cord-283382-t890r7xp	364	31	lane	lane	NN
cord-283382-t890r7xp	364	32	Production	production	NN
cord-283382-t890r7xp	364	33	of	of	IN
cord-283382-t890r7xp	364	34	adenovirus	adenovirus	NN
cord-283382-t890r7xp	364	35	vectors	vector	NNS
cord-283382-t890r7xp	364	36	and	and	CC
cord-283382-t890r7xp	364	37	their	-PRON-	PRP$
cord-283382-t890r7xp	364	38	use	use	NN
cord-283382-t890r7xp	364	39	as	as	IN
cord-283382-t890r7xp	364	40	a	a	DT
cord-283382-t890r7xp	364	41	delivery	delivery	NN
cord-283382-t890r7xp	364	42	system	system	NN
cord-283382-t890r7xp	364	43	for	for	IN
cord-283382-t890r7xp	364	44	influenza	influenza	NN
cord-283382-t890r7xp	364	45	vaccines	vaccine	NNS
cord-283382-t890r7xp	364	46	Stability	stability	NN
cord-283382-t890r7xp	364	47	and	and	CC
cord-283382-t890r7xp	364	48	suitability	suitability	NN
cord-283382-t890r7xp	364	49	for	for	IN
cord-283382-t890r7xp	364	50	storage	storage	NN
cord-283382-t890r7xp	364	51	and	and	CC
cord-283382-t890r7xp	364	52	distribution	distribution	NN
cord-283382-t890r7xp	364	53	of	of	IN
cord-283382-t890r7xp	364	54	Ad26.ZEBOV	Ad26.ZEBOV	NNP
cord-283382-t890r7xp	364	55	/	/	SYM
cord-283382-t890r7xp	364	56	MVA-	MVA-	NNP
cord-283382-t890r7xp	365	1	BN(R)-Filo	bn(r)-filo	IN
cord-283382-t890r7xp	365	2	heterologous	heterologous	JJ
cord-283382-t890r7xp	365	3	prime	prime	JJ
cord-283382-t890r7xp	365	4	-	-	HYPH
cord-283382-t890r7xp	365	5	boost	boost	NN
cord-283382-t890r7xp	365	6	Ebola	Ebola	NNP
cord-283382-t890r7xp	365	7	vaccine	vaccine	NN
cord-283382-t890r7xp	365	8	Spray	Spray	NNP
cord-283382-t890r7xp	365	9	dried	dry	VBD
cord-283382-t890r7xp	365	10	human	human	JJ
cord-283382-t890r7xp	365	11	and	and	CC
cord-283382-t890r7xp	365	12	chimpanzee	chimpanzee	NN
cord-283382-t890r7xp	365	13	adenoviral	adenoviral	NN
cord-283382-t890r7xp	365	14	-	-	HYPH
cord-283382-t890r7xp	365	15	vectored	vectore	VBN
cord-283382-t890r7xp	365	16	vaccines	vaccine	NNS
cord-283382-t890r7xp	365	17	are	be	VBP
cord-283382-t890r7xp	365	18	thermally	thermally	RB
cord-283382-t890r7xp	365	19	stable	stable	JJ
cord-283382-t890r7xp	365	20	and	and	CC
cord-283382-t890r7xp	365	21	immunogenic	immunogenic	JJ
cord-283382-t890r7xp	365	22	in	in	IN
cord-283382-t890r7xp	365	23	vivo	vivo	NNP
cord-283382-t890r7xp	365	24	Long	long	JJ
cord-283382-t890r7xp	365	25	-	-	HYPH
cord-283382-t890r7xp	365	26	term	term	NN
cord-283382-t890r7xp	365	27	thermostabilization	thermostabilization	NN
cord-283382-t890r7xp	365	28	of	of	IN
cord-283382-t890r7xp	365	29	live	live	JJ
cord-283382-t890r7xp	365	30	poxviral	poxviral	NNP
cord-283382-t890r7xp	365	31	and	and	CC
cord-283382-t890r7xp	365	32	adenoviral	adenoviral	JJ
cord-283382-t890r7xp	365	33	vaccine	vaccine	NN
cord-283382-t890r7xp	365	34	vectors	vector	NNS
cord-283382-t890r7xp	365	35	at	at	IN
cord-283382-t890r7xp	365	36	supraphysiological	supraphysiological	JJ
cord-283382-t890r7xp	365	37	temperatures	temperature	NNS
cord-283382-t890r7xp	365	38	in	in	IN
cord-283382-t890r7xp	365	39	carbohydrate	carbohydrate	NN
cord-283382-t890r7xp	365	40	glass	glass	NN
cord-283382-t890r7xp	365	41	A	a	DT
cord-283382-t890r7xp	365	42	simian	simian	JJ
cord-283382-t890r7xp	365	43	-	-	HYPH
cord-283382-t890r7xp	365	44	adenovirus	adenovirus	NN
cord-283382-t890r7xp	365	45	-	-	HYPH
cord-283382-t890r7xp	365	46	vectored	vectore	VBN
cord-283382-t890r7xp	365	47	rabies	rabie	NNS
cord-283382-t890r7xp	365	48	vaccine	vaccine	NN
cord-283382-t890r7xp	365	49	suitable	suitable	JJ
cord-283382-t890r7xp	365	50	for	for	IN
cord-283382-t890r7xp	365	51	thermostabilisation	thermostabilisation	NN
cord-283382-t890r7xp	365	52	and	and	CC
cord-283382-t890r7xp	365	53	clinical	clinical	JJ
cord-283382-t890r7xp	365	54	development	development	NN
cord-283382-t890r7xp	365	55	for	for	IN
cord-283382-t890r7xp	365	56	low	low	JJ
cord-283382-t890r7xp	365	57	-	-	HYPH
cord-283382-t890r7xp	365	58	cost	cost	NN
cord-283382-t890r7xp	365	59	single	single	JJ
cord-283382-t890r7xp	365	60	-	-	HYPH
cord-283382-t890r7xp	365	61	dose	dose	NN
cord-283382-t890r7xp	365	62	pre	pre	JJ
cord-283382-t890r7xp	365	63	-	-	JJ
cord-283382-t890r7xp	365	64	exposure	exposure	JJ
cord-283382-t890r7xp	365	65	prophylaxis	prophylaxis	NN
cord-283382-t890r7xp	365	66	Adenoviral	Adenoviral	NNP
cord-283382-t890r7xp	365	67	vectors	vector	NNS
cord-283382-t890r7xp	365	68	as	as	IN
cord-283382-t890r7xp	365	69	novel	novel	JJ
cord-283382-t890r7xp	365	70	vaccines	vaccine	NNS
cord-283382-t890r7xp	365	71	for	for	IN
cord-283382-t890r7xp	365	72	influenza	influenza	JJ
cord-283382-t890r7xp	365	73	Multiple	multiple	JJ
cord-283382-t890r7xp	365	74	innate	innate	JJ
cord-283382-t890r7xp	365	75	immune	immune	JJ
cord-283382-t890r7xp	365	76	pathways	pathway	NNS
cord-283382-t890r7xp	365	77	contribute	contribute	VBP
cord-283382-t890r7xp	365	78	to	to	IN
cord-283382-t890r7xp	365	79	the	the	DT
cord-283382-t890r7xp	365	80	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	365	81	of	of	IN
cord-283382-t890r7xp	365	82	recombinant	recombinant	JJ
cord-283382-t890r7xp	365	83	adenovirus	adenovirus	NN
cord-283382-t890r7xp	365	84	vaccine	vaccine	NN
cord-283382-t890r7xp	365	85	vectors	vector	NNS
cord-283382-t890r7xp	365	86	Innate	innate	VBP
cord-283382-t890r7xp	365	87	immune	immune	JJ
cord-283382-t890r7xp	365	88	response	response	NN
cord-283382-t890r7xp	365	89	to	to	IN
cord-283382-t890r7xp	365	90	adenoviral	adenoviral	NNP
cord-283382-t890r7xp	365	91	vectors	vector	NNS
cord-283382-t890r7xp	365	92	is	be	VBZ
cord-283382-t890r7xp	365	93	mediated	mediate	VBN
cord-283382-t890r7xp	365	94	by	by	IN
cord-283382-t890r7xp	365	95	both	both	CC
cord-283382-t890r7xp	365	96	Toll	Toll	NNP
cord-283382-t890r7xp	365	97	-	-	HYPH
cord-283382-t890r7xp	365	98	like	like	JJ
cord-283382-t890r7xp	365	99	receptor	receptor	NN
cord-283382-t890r7xp	365	100	-	-	HYPH
cord-283382-t890r7xp	365	101	dependent	dependent	JJ
cord-283382-t890r7xp	365	102	and	and	CC
cord-283382-t890r7xp	365	103	-independent	-independent	JJ
cord-283382-t890r7xp	365	104	pathways	pathway	NNS
cord-283382-t890r7xp	366	1	The	the	DT
cord-283382-t890r7xp	366	2	inflammasome	inflammasome	NN
cord-283382-t890r7xp	366	3	recognizes	recognize	VBZ
cord-283382-t890r7xp	366	4	cytosolic	cytosolic	JJ
cord-283382-t890r7xp	366	5	microbial	microbial	NN
cord-283382-t890r7xp	366	6	and	and	CC
cord-283382-t890r7xp	366	7	host	host	NN
cord-283382-t890r7xp	366	8	DNA	dna	NN
cord-283382-t890r7xp	366	9	and	and	CC
cord-283382-t890r7xp	366	10	triggers	trigger	VBZ
cord-283382-t890r7xp	366	11	an	an	DT
cord-283382-t890r7xp	366	12	innate	innate	JJ
cord-283382-t890r7xp	366	13	immune	immune	JJ
cord-283382-t890r7xp	366	14	response	response	NN
cord-283382-t890r7xp	366	15	Adenovirus	Adenovirus	NNP
cord-283382-t890r7xp	366	16	sensing	sensing	NN
cord-283382-t890r7xp	366	17	by	by	IN
cord-283382-t890r7xp	366	18	the	the	DT
cord-283382-t890r7xp	366	19	immune	immune	JJ
cord-283382-t890r7xp	366	20	system	system	NN
cord-283382-t890r7xp	367	1	Adenovirus	Adenovirus	NNP
cord-283382-t890r7xp	367	2	vector	vector	NN
cord-283382-t890r7xp	367	3	-	-	HYPH
cord-283382-t890r7xp	367	4	induced	induce	VBN
cord-283382-t890r7xp	367	5	innate	innate	JJ
cord-283382-t890r7xp	367	6	inflammatory	inflammatory	JJ
cord-283382-t890r7xp	367	7	mediators	mediator	NNS
cord-283382-t890r7xp	367	8	,	,	,
cord-283382-t890r7xp	367	9	MAPK	MAPK	NNP
cord-283382-t890r7xp	367	10	signaling	signal	VBG
cord-283382-t890r7xp	367	11	,	,	,
cord-283382-t890r7xp	367	12	as	as	RB
cord-283382-t890r7xp	367	13	well	well	RB
cord-283382-t890r7xp	367	14	as	as	IN
cord-283382-t890r7xp	367	15	adaptive	adaptive	JJ
cord-283382-t890r7xp	367	16	immune	immune	JJ
cord-283382-t890r7xp	367	17	responses	response	NNS
cord-283382-t890r7xp	367	18	are	be	VBP
cord-283382-t890r7xp	367	19	dependent	dependent	JJ
cord-283382-t890r7xp	367	20	upon	upon	IN
cord-283382-t890r7xp	367	21	both	both	DT
cord-283382-t890r7xp	367	22	TLR2	TLR2	NNP
cord-283382-t890r7xp	367	23	and	and	CC
cord-283382-t890r7xp	367	24	TLR9	TLR9	NNP
cord-283382-t890r7xp	367	25	in	in	IN
cord-283382-t890r7xp	368	1	vivo	vivo	NNP
cord-283382-t890r7xp	368	2	TLRs	TLRs	NNP
cord-283382-t890r7xp	368	3	differentially	differentially	RB
cord-283382-t890r7xp	368	4	modulate	modulate	VBP
cord-283382-t890r7xp	368	5	several	several	JJ
cord-283382-t890r7xp	368	6	adenovirus	adenovirus	NN
cord-283382-t890r7xp	368	7	vector	vector	NN
cord-283382-t890r7xp	368	8	-	-	HYPH
cord-283382-t890r7xp	368	9	induced	induce	VBN
cord-283382-t890r7xp	368	10	immune	immune	JJ
cord-283382-t890r7xp	368	11	responses	response	NNS
cord-283382-t890r7xp	368	12	Adenovirus	Adenovirus	NNP
cord-283382-t890r7xp	368	13	detection	detection	NN
cord-283382-t890r7xp	368	14	by	by	IN
cord-283382-t890r7xp	368	15	the	the	DT
cord-283382-t890r7xp	368	16	cGAS	cgas	NN
cord-283382-t890r7xp	368	17	/	/	SYM
cord-283382-t890r7xp	368	18	STING	sting	NN
cord-283382-t890r7xp	368	19	/	/	SYM
cord-283382-t890r7xp	368	20	TBK1	TBK1	NNP
cord-283382-t890r7xp	368	21	DNA	dna	NN
cord-283382-t890r7xp	368	22	sensing	sensing	NN
cord-283382-t890r7xp	368	23	cascade	cascade	NN
cord-283382-t890r7xp	368	24	Diminished	diminish	VBN
cord-283382-t890r7xp	368	25	innate	innate	JJ
cord-283382-t890r7xp	368	26	antiviral	antiviral	JJ
cord-283382-t890r7xp	368	27	response	response	NN
cord-283382-t890r7xp	368	28	to	to	IN
cord-283382-t890r7xp	368	29	adenovirus	adenovirus	NN
cord-283382-t890r7xp	368	30	vectors	vector	NNS
cord-283382-t890r7xp	368	31	in	in	IN
cord-283382-t890r7xp	368	32	cGAS	cgas	JJ
cord-283382-t890r7xp	368	33	/	/	SYM
cord-283382-t890r7xp	368	34	STING	sting	NN
cord-283382-t890r7xp	368	35	-	-	HYPH
cord-283382-t890r7xp	368	36	deficient	deficient	JJ
cord-283382-t890r7xp	368	37	mice	mouse	NNS
cord-283382-t890r7xp	368	38	minimally	minimally	RB
cord-283382-t890r7xp	368	39	impacts	impact	VBZ
cord-283382-t890r7xp	368	40	adaptive	adaptive	JJ
cord-283382-t890r7xp	368	41	immunity	immunity	NN
cord-283382-t890r7xp	368	42	STING	sting	NN
cord-283382-t890r7xp	368	43	is	be	VBZ
cord-283382-t890r7xp	368	44	a	a	DT
cord-283382-t890r7xp	368	45	direct	direct	JJ
cord-283382-t890r7xp	368	46	innate	innate	JJ
cord-283382-t890r7xp	368	47	immune	immune	JJ
cord-283382-t890r7xp	368	48	sensor	sensor	NN
cord-283382-t890r7xp	368	49	of	of	IN
cord-283382-t890r7xp	368	50	cyclic	cyclic	JJ
cord-283382-t890r7xp	368	51	di	di	FW
cord-283382-t890r7xp	368	52	-	-	HYPH
cord-283382-t890r7xp	368	53	GMP	GMP	NNP
cord-283382-t890r7xp	368	54	Adenovirus	Adenovirus	NNP
cord-283382-t890r7xp	368	55	vector	vector	NN
cord-283382-t890r7xp	368	56	induced	induce	VBN
cord-283382-t890r7xp	368	57	innate	innate	JJ
cord-283382-t890r7xp	368	58	immune	immune	JJ
cord-283382-t890r7xp	368	59	responses	response	NNS
cord-283382-t890r7xp	368	60	:	:	:
cord-283382-t890r7xp	368	61	impact	impact	NN
cord-283382-t890r7xp	368	62	upon	upon	IN
cord-283382-t890r7xp	368	63	efficacy	efficacy	NN
cord-283382-t890r7xp	368	64	and	and	CC
cord-283382-t890r7xp	368	65	toxicity	toxicity	NN
cord-283382-t890r7xp	368	66	in	in	IN
cord-283382-t890r7xp	368	67	gene	gene	NN
cord-283382-t890r7xp	368	68	therapy	therapy	NN
cord-283382-t890r7xp	368	69	and	and	CC
cord-283382-t890r7xp	368	70	vaccine	vaccine	NN
cord-283382-t890r7xp	368	71	applications	application	NNS
cord-283382-t890r7xp	369	1	Innate	innate	JJ
cord-283382-t890r7xp	369	2	immunity	immunity	NN
cord-283382-t890r7xp	369	3	to	to	IN
cord-283382-t890r7xp	369	4	adenovirus	adenovirus	NN
cord-283382-t890r7xp	369	5	Type	type	NN
cord-283382-t890r7xp	370	1	I	-PRON-	PRP
cord-283382-t890r7xp	370	2	interferon	interferon	RB
cord-283382-t890r7xp	370	3	inhibits	inhibit	VBZ
cord-283382-t890r7xp	370	4	antibody	antibody	NN
cord-283382-t890r7xp	370	5	responses	response	NNS
cord-283382-t890r7xp	370	6	induced	induce	VBN
cord-283382-t890r7xp	370	7	by	by	IN
cord-283382-t890r7xp	370	8	a	a	DT
cord-283382-t890r7xp	370	9	chimpanzee	chimpanzee	NN
cord-283382-t890r7xp	370	10	adenovirus	adenovirus	NN
cord-283382-t890r7xp	370	11	vector	vector	NN
cord-283382-t890r7xp	370	12	Persistence	persistence	NN
cord-283382-t890r7xp	370	13	of	of	IN
cord-283382-t890r7xp	370	14	transgene	transgene	JJ
cord-283382-t890r7xp	370	15	expression	expression	NN
cord-283382-t890r7xp	370	16	influences	influence	VBZ
cord-283382-t890r7xp	370	17	CD8	CD8	NNP
cord-283382-t890r7xp	370	18	+	+	CC
cord-283382-t890r7xp	370	19	T	t	NN
cord-283382-t890r7xp	370	20	-	-	HYPH
cord-283382-t890r7xp	370	21	cell	cell	NN
cord-283382-t890r7xp	370	22	expansion	expansion	NN
cord-283382-t890r7xp	370	23	and	and	CC
cord-283382-t890r7xp	370	24	maintenance	maintenance	NN
cord-283382-t890r7xp	370	25	following	follow	VBG
cord-283382-t890r7xp	370	26	immunization	immunization	NN
cord-283382-t890r7xp	370	27	with	with	IN
cord-283382-t890r7xp	370	28	recombinant	recombinant	JJ
cord-283382-t890r7xp	370	29	adenovirus	adenovirus	NN
cord-283382-t890r7xp	371	1	The	the	DT
cord-283382-t890r7xp	371	2	CD8	CD8	NNP
cord-283382-t890r7xp	371	3	+	+	CC
cord-283382-t890r7xp	371	4	T	T	NNP
cord-283382-t890r7xp	371	5	cell	cell	NN
cord-283382-t890r7xp	371	6	population	population	NN
cord-283382-t890r7xp	371	7	elicited	elicit	VBN
cord-283382-t890r7xp	371	8	by	by	IN
cord-283382-t890r7xp	371	9	recombinant	recombinant	JJ
cord-283382-t890r7xp	371	10	adenovirus	adenovirus	NN
cord-283382-t890r7xp	371	11	displays	display	VBZ
cord-283382-t890r7xp	371	12	a	a	DT
cord-283382-t890r7xp	371	13	novel	novel	NN
cord-283382-t890r7xp	371	14	partially	partially	RB
cord-283382-t890r7xp	371	15	exhausted	exhaust	VBN
cord-283382-t890r7xp	371	16	phenotype	phenotype	NN
cord-283382-t890r7xp	371	17	associated	associate	VBN
cord-283382-t890r7xp	371	18	with	with	IN
cord-283382-t890r7xp	371	19	prolonged	prolong	VBN
cord-283382-t890r7xp	371	20	antigen	antigen	NN
cord-283382-t890r7xp	371	21	presentation	presentation	NN
cord-283382-t890r7xp	371	22	that	that	WDT
cord-283382-t890r7xp	371	23	nonetheless	nonetheless	RB
cord-283382-t890r7xp	371	24	provides	provide	VBZ
cord-283382-t890r7xp	371	25	long	long	JJ
cord-283382-t890r7xp	371	26	-	-	HYPH
cord-283382-t890r7xp	371	27	term	term	NN
cord-283382-t890r7xp	371	28	immunity	immunity	NN
cord-283382-t890r7xp	371	29	Differential	differential	JJ
cord-283382-t890r7xp	371	30	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	371	31	between	between	IN
cord-283382-t890r7xp	371	32	HAdV-5	HAdV-5	NNP
cord-283382-t890r7xp	372	1	and	and	CC
cord-283382-t890r7xp	372	2	chimpanzee	chimpanzee	NN
cord-283382-t890r7xp	372	3	adenovirus	adenovirus	NN
cord-283382-t890r7xp	372	4	vector	vector	NN
cord-283382-t890r7xp	372	5	ChAdOx1	ChAdOx1	NNP
cord-283382-t890r7xp	372	6	is	be	VBZ
cord-283382-t890r7xp	372	7	independent	independent	JJ
cord-283382-t890r7xp	372	8	of	of	IN
cord-283382-t890r7xp	372	9	fiber	fiber	NN
cord-283382-t890r7xp	372	10	and	and	CC
cord-283382-t890r7xp	372	11	penton	penton	NNP
cord-283382-t890r7xp	372	12	RGD	RGD	NNP
cord-283382-t890r7xp	372	13	loop	loop	NN
cord-283382-t890r7xp	372	14	sequences	sequence	NNS
cord-283382-t890r7xp	372	15	in	in	IN
cord-283382-t890r7xp	372	16	mice	mouse	NNS
cord-283382-t890r7xp	372	17	Translating	translate	VBG
cord-283382-t890r7xp	372	18	innate	innate	JJ
cord-283382-t890r7xp	372	19	immunity	immunity	NN
cord-283382-t890r7xp	372	20	into	into	IN
cord-283382-t890r7xp	372	21	immunological	immunological	JJ
cord-283382-t890r7xp	372	22	memory	memory	NN
cord-283382-t890r7xp	372	23	:	:	:
cord-283382-t890r7xp	373	1	implications	implication	NNS
cord-283382-t890r7xp	373	2	for	for	IN
cord-283382-t890r7xp	373	3	vaccine	vaccine	NN
cord-283382-t890r7xp	373	4	development	development	NN
cord-283382-t890r7xp	373	5	Antigen	Antigen	NNP
cord-283382-t890r7xp	373	6	presentation	presentation	NN
cord-283382-t890r7xp	373	7	by	by	IN
cord-283382-t890r7xp	373	8	nonhemopoietic	nonhemopoietic	JJ
cord-283382-t890r7xp	373	9	cells	cell	NNS
cord-283382-t890r7xp	373	10	amplifies	amplify	VBZ
cord-283382-t890r7xp	373	11	clonal	clonal	JJ
cord-283382-t890r7xp	373	12	expansion	expansion	NN
cord-283382-t890r7xp	373	13	of	of	IN
cord-283382-t890r7xp	373	14	effector	effector	NN
cord-283382-t890r7xp	373	15	CD8	CD8	NNP
cord-283382-t890r7xp	373	16	T	T	NNP
cord-283382-t890r7xp	373	17	cells	cell	NNS
cord-283382-t890r7xp	373	18	in	in	IN
cord-283382-t890r7xp	373	19	a	a	DT
cord-283382-t890r7xp	373	20	pathogen	pathogen	NN
cord-283382-t890r7xp	373	21	-	-	HYPH
cord-283382-t890r7xp	373	22	specific	specific	JJ
cord-283382-t890r7xp	373	23	manner	manner	JJ
cord-283382-t890r7xp	373	24	Presentation	presentation	NN
cord-283382-t890r7xp	373	25	of	of	IN
cord-283382-t890r7xp	373	26	Toxoplasma	Toxoplasma	NNP
cord-283382-t890r7xp	373	27	gondii	gondii	NN
cord-283382-t890r7xp	373	28	antigens	antigen	NNS
cord-283382-t890r7xp	373	29	via	via	IN
cord-283382-t890r7xp	373	30	the	the	DT
cord-283382-t890r7xp	373	31	endogenous	endogenous	JJ
cord-283382-t890r7xp	373	32	major	major	JJ
cord-283382-t890r7xp	373	33	histocompatibility	histocompatibility	NN
cord-283382-t890r7xp	373	34	complex	complex	JJ
cord-283382-t890r7xp	373	35	class	class	NN
cord-283382-t890r7xp	373	36	I	-PRON-	PRP
cord-283382-t890r7xp	373	37	pathway	pathway	VBP
cord-283382-t890r7xp	373	38	in	in	IN
cord-283382-t890r7xp	373	39	nonprofessional	nonprofessional	JJ
cord-283382-t890r7xp	373	40	and	and	CC
cord-283382-t890r7xp	373	41	professional	professional	JJ
cord-283382-t890r7xp	373	42	antigen	antigen	NN
cord-283382-t890r7xp	373	43	-	-	HYPH
cord-283382-t890r7xp	373	44	presenting	present	VBG
cord-283382-t890r7xp	373	45	cells	cell	NNS
cord-283382-t890r7xp	373	46	Immunity	immunity	NN
cord-283382-t890r7xp	373	47	against	against	IN
cord-283382-t890r7xp	373	48	heterosubtypic	heterosubtypic	NNP
cord-283382-t890r7xp	373	49	influenza	influenza	NN
cord-283382-t890r7xp	373	50	virus	virus	NN
cord-283382-t890r7xp	373	51	induced	induce	VBN
cord-283382-t890r7xp	373	52	by	by	IN
cord-283382-t890r7xp	373	53	adenovirus	adenovirus	NN
cord-283382-t890r7xp	373	54	and	and	CC
cord-283382-t890r7xp	373	55	MVA	MVA	NNP
cord-283382-t890r7xp	373	56	expressing	express	VBG
cord-283382-t890r7xp	373	57	nucleoprotein	nucleoprotein	NNP
cord-283382-t890r7xp	373	58	and	and	CC
cord-283382-t890r7xp	373	59	matrix	matrix	NNP
cord-283382-t890r7xp	373	60	protein-1	protein-1	NNP
cord-283382-t890r7xp	373	61	Route	Route	NNP
cord-283382-t890r7xp	373	62	of	of	IN
cord-283382-t890r7xp	373	63	adenovirus	adenovirus	NN
cord-283382-t890r7xp	373	64	-	-	HYPH
cord-283382-t890r7xp	373	65	based	base	VBN
cord-283382-t890r7xp	373	66	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	373	67	vaccine	vaccine	NN
cord-283382-t890r7xp	373	68	delivery	delivery	NN
cord-283382-t890r7xp	373	69	impacts	impact	VBZ
cord-283382-t890r7xp	373	70	the	the	DT
cord-283382-t890r7xp	373	71	phenotype	phenotype	NN
cord-283382-t890r7xp	373	72	and	and	CC
cord-283382-t890r7xp	373	73	trafficking	trafficking	NN
cord-283382-t890r7xp	373	74	of	of	IN
cord-283382-t890r7xp	373	75	vaccine	vaccine	NN
cord-283382-t890r7xp	373	76	-	-	HYPH
cord-283382-t890r7xp	373	77	elicited	elicit	VBN
cord-283382-t890r7xp	373	78	CD8	CD8	NNP
cord-283382-t890r7xp	373	79	+	+	CC
cord-283382-t890r7xp	373	80	T	t	NN
cord-283382-t890r7xp	373	81	lymphocytes	lymphocyte	NNS
cord-283382-t890r7xp	373	82	Combined	combine	VBN
cord-283382-t890r7xp	373	83	fiber	fiber	NN
cord-283382-t890r7xp	373	84	modifications	modification	NNS
cord-283382-t890r7xp	373	85	both	both	DT
cord-283382-t890r7xp	373	86	to	to	TO
cord-283382-t890r7xp	373	87	target	target	VB
cord-283382-t890r7xp	373	88	alpha(v)beta(6	alpha(v)beta(6	NNP
cord-283382-t890r7xp	373	89	)	)	-RRB-
cord-283382-t890r7xp	373	90	and	and	CC
cord-283382-t890r7xp	373	91	detarget	detarget	VB
cord-283382-t890r7xp	373	92	the	the	DT
cord-283382-t890r7xp	373	93	coxsackievirus	coxsackievirus	NNP
cord-283382-t890r7xp	373	94	-	-	HYPH
cord-283382-t890r7xp	373	95	adenovirus	adenovirus	NN
cord-283382-t890r7xp	373	96	receptor	receptor	NN
cord-283382-t890r7xp	373	97	improve	improve	VB
cord-283382-t890r7xp	373	98	virus	virus	NN
cord-283382-t890r7xp	373	99	toxicity	toxicity	NN
cord-283382-t890r7xp	373	100	profiles	profile	NNS
cord-283382-t890r7xp	373	101	in	in	IN
cord-283382-t890r7xp	373	102	vivo	vivo	NN
cord-283382-t890r7xp	373	103	but	but	CC
cord-283382-t890r7xp	373	104	fail	fail	VBP
cord-283382-t890r7xp	373	105	to	to	TO
cord-283382-t890r7xp	373	106	improve	improve	VB
cord-283382-t890r7xp	373	107	antitumoral	antitumoral	JJ
cord-283382-t890r7xp	373	108	efficacy	efficacy	NN
cord-283382-t890r7xp	373	109	relative	relative	JJ
cord-283382-t890r7xp	373	110	to	to	IN
cord-283382-t890r7xp	373	111	adenovirus	adenovirus	NN
cord-283382-t890r7xp	373	112	serotype	serotype	NN
cord-283382-t890r7xp	373	113	5	5	CD
cord-283382-t890r7xp	373	114	Biodistribution	Biodistribution	NNP
cord-283382-t890r7xp	373	115	and	and	CC
cord-283382-t890r7xp	373	116	retargeting	retargeting	NN
cord-283382-t890r7xp	373	117	of	of	IN
cord-283382-t890r7xp	373	118	FX	FX	NNP
cord-283382-t890r7xp	373	119	-	-	HYPH
cord-283382-t890r7xp	373	120	binding	bind	VBG
cord-283382-t890r7xp	373	121	ablated	ablate	VBN
cord-283382-t890r7xp	373	122	adenovirus	adenovirus	NN
cord-283382-t890r7xp	373	123	serotype	serotype	NN
cord-283382-t890r7xp	373	124	5	5	CD
cord-283382-t890r7xp	373	125	Adenovirus	Adenovirus	NNP
cord-283382-t890r7xp	373	126	binding	bind	VBG
cord-283382-t890r7xp	373	127	to	to	IN
cord-283382-t890r7xp	373	128	blood	blood	NN
cord-283382-t890r7xp	373	129	factors	factor	NNS
cord-283382-t890r7xp	373	130	results	result	NNS
cord-283382-t890r7xp	373	131	in	in	IN
cord-283382-t890r7xp	373	132	liver	liver	NN
cord-283382-t890r7xp	373	133	cell	cell	NN
cord-283382-t890r7xp	373	134	infection	infection	NN
cord-283382-t890r7xp	373	135	and	and	CC
cord-283382-t890r7xp	374	1	hepatotoxicity	hepatotoxicity	NNP
cord-283382-t890r7xp	374	2	Adenovirus	Adenovirus	NNP
cord-283382-t890r7xp	374	3	serotype	serotype	NN
cord-283382-t890r7xp	374	4	5	5	CD
cord-283382-t890r7xp	374	5	hexon	hexon	NNP
cord-283382-t890r7xp	374	6	mediates	mediate	VBZ
cord-283382-t890r7xp	374	7	liver	liver	NN
cord-283382-t890r7xp	374	8	gene	gene	NN
cord-283382-t890r7xp	374	9	transfer	transfer	NN
cord-283382-t890r7xp	374	10	Biodistribution	Biodistribution	NNP
cord-283382-t890r7xp	374	11	and	and	CC
cord-283382-t890r7xp	374	12	inflammatory	inflammatory	JJ
cord-283382-t890r7xp	374	13	profiles	profile	NNS
cord-283382-t890r7xp	374	14	of	of	IN
cord-283382-t890r7xp	374	15	novel	novel	NNP
cord-283382-t890r7xp	374	16	penton	penton	NNP
cord-283382-t890r7xp	374	17	and	and	CC
cord-283382-t890r7xp	374	18	hexon	hexon	NNP
cord-283382-t890r7xp	374	19	double	double	JJ
cord-283382-t890r7xp	374	20	-	-	HYPH
cord-283382-t890r7xp	374	21	mutant	mutant	JJ
cord-283382-t890r7xp	374	22	serotype	serotype	NN
cord-283382-t890r7xp	375	1	5	5	CD
cord-283382-t890r7xp	375	2	adenoviruses	adenovirus	NNS
cord-283382-t890r7xp	375	3	Requirements	requirement	NNS
cord-283382-t890r7xp	375	4	for	for	IN
cord-283382-t890r7xp	375	5	receptor	receptor	NN
cord-283382-t890r7xp	375	6	engagement	engagement	NN
cord-283382-t890r7xp	375	7	during	during	IN
cord-283382-t890r7xp	375	8	infection	infection	NN
cord-283382-t890r7xp	375	9	by	by	IN
cord-283382-t890r7xp	375	10	adenovirus	adenovirus	NN
cord-283382-t890r7xp	375	11	complexed	complexe	VBN
cord-283382-t890r7xp	375	12	with	with	IN
cord-283382-t890r7xp	375	13	blood	blood	NN
cord-283382-t890r7xp	375	14	coagulation	coagulation	NN
cord-283382-t890r7xp	375	15	factor	factor	NN
cord-283382-t890r7xp	375	16	X	x	NN
cord-283382-t890r7xp	375	17	Innate	innate	JJ
cord-283382-t890r7xp	375	18	immunity	immunity	NN
cord-283382-t890r7xp	375	19	to	to	IN
cord-283382-t890r7xp	375	20	adenovirus	adenovirus	NN
cord-283382-t890r7xp	375	21	:	:	:
cord-283382-t890r7xp	375	22	lessons	lesson	NNS
cord-283382-t890r7xp	375	23	from	from	IN
cord-283382-t890r7xp	375	24	mice	mouse	NNS
cord-283382-t890r7xp	376	1	Normal	normal	JJ
cord-283382-t890r7xp	376	2	human	human	JJ
cord-283382-t890r7xp	376	3	lymph	lymph	NN
cord-283382-t890r7xp	376	4	node	node	NN
cord-283382-t890r7xp	376	5	T	T	NNP
cord-283382-t890r7xp	376	6	follicular	follicular	JJ
cord-283382-t890r7xp	376	7	helper	helper	NN
cord-283382-t890r7xp	376	8	cells	cell	NNS
cord-283382-t890r7xp	376	9	and	and	CC
cord-283382-t890r7xp	376	10	germinal	germinal	JJ
cord-283382-t890r7xp	376	11	center	center	NN
cord-283382-t890r7xp	376	12	B	B	NNP
cord-283382-t890r7xp	376	13	cells	cell	NNS
cord-283382-t890r7xp	376	14	accessed	access	VBN
cord-283382-t890r7xp	376	15	via	via	IN
cord-283382-t890r7xp	376	16	fine	fine	JJ
cord-283382-t890r7xp	376	17	needle	needle	NN
cord-283382-t890r7xp	376	18	aspirations	aspiration	NNS
cord-283382-t890r7xp	377	1	Recombinant	recombinant	JJ
cord-283382-t890r7xp	377	2	adenovirus	adenovirus	NN
cord-283382-t890r7xp	377	3	vaccines	vaccine	NNS
cord-283382-t890r7xp	377	4	can	can	MD
cord-283382-t890r7xp	377	5	successfully	successfully	RB
cord-283382-t890r7xp	377	6	elicit	elicit	VB
cord-283382-t890r7xp	377	7	CD8	CD8	NNP
cord-283382-t890r7xp	377	8	+	+	CC
cord-283382-t890r7xp	377	9	T	t	NN
cord-283382-t890r7xp	377	10	cell	cell	NN
cord-283382-t890r7xp	377	11	immunity	immunity	NN
cord-283382-t890r7xp	377	12	under	under	IN
cord-283382-t890r7xp	377	13	conditions	condition	NNS
cord-283382-t890r7xp	377	14	of	of	IN
cord-283382-t890r7xp	377	15	extreme	extreme	JJ
cord-283382-t890r7xp	377	16	leukopenia	leukopenia	NN
cord-283382-t890r7xp	377	17	Harnessing	harness	VBG
cord-283382-t890r7xp	377	18	the	the	DT
cord-283382-t890r7xp	377	19	potential	potential	NN
cord-283382-t890r7xp	377	20	of	of	IN
cord-283382-t890r7xp	377	21	adenovirus	adenovirus	NN
cord-283382-t890r7xp	377	22	vectored	vectore	VBN
cord-283382-t890r7xp	377	23	vaccines	vaccine	NNS
cord-283382-t890r7xp	377	24	Overcoming	overcome	VBG
cord-283382-t890r7xp	377	25	barriers	barrier	NNS
cord-283382-t890r7xp	377	26	in	in	IN
cord-283382-t890r7xp	377	27	the	the	DT
cord-283382-t890r7xp	377	28	path	path	NN
cord-283382-t890r7xp	377	29	to	to	IN
cord-283382-t890r7xp	377	30	a	a	DT
cord-283382-t890r7xp	377	31	universal	universal	JJ
cord-283382-t890r7xp	377	32	influenza	influenza	NN
cord-283382-t890r7xp	377	33	virus	virus	NN
cord-283382-t890r7xp	377	34	vaccine	vaccine	NN
cord-283382-t890r7xp	377	35	Superior	Superior	NNP
cord-283382-t890r7xp	377	36	immune	immune	JJ
cord-283382-t890r7xp	377	37	responses	response	NNS
cord-283382-t890r7xp	377	38	induced	induce	VBN
cord-283382-t890r7xp	377	39	by	by	IN
cord-283382-t890r7xp	377	40	intranasal	intranasal	NN
cord-283382-t890r7xp	377	41	immunization	immunization	NN
cord-283382-t890r7xp	377	42	with	with	IN
cord-283382-t890r7xp	377	43	recombinant	recombinant	JJ
cord-283382-t890r7xp	377	44	adenovirus	adenovirus	NN
cord-283382-t890r7xp	377	45	-	-	HYPH
cord-283382-t890r7xp	377	46	based	base	VBN
cord-283382-t890r7xp	377	47	vaccine	vaccine	NN
cord-283382-t890r7xp	377	48	expressing	express	VBG
cord-283382-t890r7xp	377	49	full	full	JJ
cord-283382-t890r7xp	377	50	-	-	HYPH
cord-283382-t890r7xp	377	51	length	length	NN
cord-283382-t890r7xp	377	52	Spike	Spike	NNP
cord-283382-t890r7xp	377	53	Protein	Protein	NNP
cord-283382-t890r7xp	377	54	of	of	IN
cord-283382-t890r7xp	377	55	Middle	Middle	NNP
cord-283382-t890r7xp	377	56	East	East	NNP
cord-283382-t890r7xp	377	57	respiratory	respiratory	JJ
cord-283382-t890r7xp	377	58	syndrome	syndrome	NN
cord-283382-t890r7xp	377	59	coronavirus	coronavirus	NN
cord-283382-t890r7xp	377	60	Single	single	JJ
cord-283382-t890r7xp	377	61	intranasal	intranasal	NN
cord-283382-t890r7xp	377	62	immunization	immunization	NN
cord-283382-t890r7xp	377	63	with	with	IN
cord-283382-t890r7xp	377	64	chimpanzee	chimpanzee	NN
cord-283382-t890r7xp	377	65	adenovirusbased	adenovirusbase	VBN
cord-283382-t890r7xp	377	66	vaccine	vaccine	NN
cord-283382-t890r7xp	377	67	induces	induce	VBZ
cord-283382-t890r7xp	377	68	sustained	sustained	JJ
cord-283382-t890r7xp	377	69	and	and	CC
cord-283382-t890r7xp	377	70	protective	protective	JJ
cord-283382-t890r7xp	377	71	immunity	immunity	NN
cord-283382-t890r7xp	377	72	against	against	IN
cord-283382-t890r7xp	377	73	MERS	MERS	NNP
cord-283382-t890r7xp	377	74	-	-	HYPH
cord-283382-t890r7xp	377	75	CoV	CoV	NNP
cord-283382-t890r7xp	377	76	infection	infection	NN
cord-283382-t890r7xp	377	77	Comparison	comparison	NN
cord-283382-t890r7xp	377	78	of	of	IN
cord-283382-t890r7xp	377	79	systemic	systemic	JJ
cord-283382-t890r7xp	377	80	and	and	CC
cord-283382-t890r7xp	377	81	mucosal	mucosal	JJ
cord-283382-t890r7xp	377	82	immunization	immunization	NN
cord-283382-t890r7xp	377	83	with	with	IN
cord-283382-t890r7xp	377	84	replicating	replicate	VBG
cord-283382-t890r7xp	377	85	Single	single	JJ
cord-283382-t890r7xp	377	86	cycle	cycle	NN
cord-283382-t890r7xp	377	87	Adenoviruses	adenovirus	NNS
cord-283382-t890r7xp	377	88	Unique	Unique	NNP
cord-283382-t890r7xp	377	89	cellular	cellular	JJ
cord-283382-t890r7xp	377	90	and	and	CC
cord-283382-t890r7xp	377	91	humoral	humoral	JJ
cord-283382-t890r7xp	377	92	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	377	93	profiles	profile	NNS
cord-283382-t890r7xp	377	94	generated	generate	VBN
cord-283382-t890r7xp	377	95	by	by	IN
cord-283382-t890r7xp	377	96	aerosol	aerosol	NN
cord-283382-t890r7xp	377	97	,	,	,
cord-283382-t890r7xp	377	98	intranasal	intranasal	NN
cord-283382-t890r7xp	377	99	,	,	,
cord-283382-t890r7xp	377	100	or	or	CC
cord-283382-t890r7xp	377	101	parenteral	parenteral	JJ
cord-283382-t890r7xp	377	102	vaccination	vaccination	NN
cord-283382-t890r7xp	377	103	in	in	IN
cord-283382-t890r7xp	377	104	rhesus	rhesu	NNS
cord-283382-t890r7xp	377	105	macaques	macaque	NNS
cord-283382-t890r7xp	377	106	Novel	Novel	NNP
cord-283382-t890r7xp	377	107	chimpanzee	chimpanzee	NN
cord-283382-t890r7xp	377	108	adenovirus	adenovirus	NN
cord-283382-t890r7xp	377	109	-	-	HYPH
cord-283382-t890r7xp	377	110	vectored	vectore	VBN
cord-283382-t890r7xp	377	111	respiratory	respiratory	JJ
cord-283382-t890r7xp	377	112	mucosal	mucosal	JJ
cord-283382-t890r7xp	377	113	tuberculosis	tuberculosis	NN
cord-283382-t890r7xp	377	114	vaccine	vaccine	NN
cord-283382-t890r7xp	377	115	:	:	:
cord-283382-t890r7xp	377	116	overcoming	overcome	VBG
cord-283382-t890r7xp	377	117	local	local	JJ
cord-283382-t890r7xp	377	118	anti	anti	JJ
cord-283382-t890r7xp	377	119	-	-	JJ
cord-283382-t890r7xp	377	120	human	human	JJ
cord-283382-t890r7xp	377	121	adenovirus	adenovirus	NN
cord-283382-t890r7xp	377	122	immunity	immunity	NN
cord-283382-t890r7xp	377	123	for	for	IN
cord-283382-t890r7xp	377	124	potent	potent	JJ
cord-283382-t890r7xp	377	125	TB	TB	NNP
cord-283382-t890r7xp	377	126	protection	protection	NN
cord-283382-t890r7xp	377	127	Protective	protective	JJ
cord-283382-t890r7xp	377	128	anti	anti	JJ
cord-283382-t890r7xp	377	129	-	-	JJ
cord-283382-t890r7xp	377	130	Pseudomonas	Pseudomonas	NNP
cord-283382-t890r7xp	377	131	aeruginosa	aeruginosa	NN
cord-283382-t890r7xp	377	132	humoral	humoral	JJ
cord-283382-t890r7xp	377	133	and	and	CC
cord-283382-t890r7xp	377	134	cellular	cellular	JJ
cord-283382-t890r7xp	377	135	mucosal	mucosal	JJ
cord-283382-t890r7xp	377	136	immunity	immunity	NN
cord-283382-t890r7xp	377	137	by	by	IN
cord-283382-t890r7xp	377	138	AdC7-mediated	adc7-mediated	JJ
cord-283382-t890r7xp	377	139	expression	expression	NN
cord-283382-t890r7xp	377	140	of	of	IN
cord-283382-t890r7xp	377	141	the	the	DT
cord-283382-t890r7xp	377	142	P.	P.	NNP
cord-283382-t890r7xp	377	143	aeruginosa	aeruginosa	NN
cord-283382-t890r7xp	377	144	protein	protein	NN
cord-283382-t890r7xp	377	145	OprF	OprF	NNP
cord-283382-t890r7xp	377	146	Adenovirus	Adenovirus	NNP
cord-283382-t890r7xp	378	1	hexon	hexon	NNP
cord-283382-t890r7xp	378	2	protein	protein	NNP
cord-283382-t890r7xp	378	3	is	be	VBZ
cord-283382-t890r7xp	378	4	a	a	DT
cord-283382-t890r7xp	378	5	potent	potent	JJ
cord-283382-t890r7xp	378	6	adjuvant	adjuvant	NN
cord-283382-t890r7xp	378	7	for	for	IN
cord-283382-t890r7xp	378	8	activation	activation	NN
cord-283382-t890r7xp	378	9	of	of	IN
cord-283382-t890r7xp	378	10	a	a	DT
cord-283382-t890r7xp	378	11	cellular	cellular	JJ
cord-283382-t890r7xp	378	12	immune	immune	JJ
cord-283382-t890r7xp	378	13	response	response	NN
cord-283382-t890r7xp	378	14	Interaction	Interaction	NNP
cord-283382-t890r7xp	378	15	of	of	IN
cord-283382-t890r7xp	378	16	adenovirus	adenovirus	NN
cord-283382-t890r7xp	378	17	type	type	NN
cord-283382-t890r7xp	378	18	5	5	CD
cord-283382-t890r7xp	378	19	fiber	fiber	NN
cord-283382-t890r7xp	378	20	with	with	IN
cord-283382-t890r7xp	378	21	the	the	DT
cord-283382-t890r7xp	378	22	coxsackievirus	coxsackievirus	NNP
cord-283382-t890r7xp	378	23	and	and	CC
cord-283382-t890r7xp	378	24	adenovirus	adenovirus	NN
cord-283382-t890r7xp	378	25	receptor	receptor	NN
cord-283382-t890r7xp	379	1	activates	activate	VBZ
cord-283382-t890r7xp	379	2	inflammatory	inflammatory	JJ
cord-283382-t890r7xp	379	3	response	response	NN
cord-283382-t890r7xp	379	4	in	in	IN
cord-283382-t890r7xp	379	5	human	human	JJ
cord-283382-t890r7xp	379	6	respiratory	respiratory	JJ
cord-283382-t890r7xp	379	7	cells	cell	NNS
cord-283382-t890r7xp	379	8	Influence	influence	NN
cord-283382-t890r7xp	379	9	of	of	IN
cord-283382-t890r7xp	379	10	fiber	fiber	NN
cord-283382-t890r7xp	379	11	detargeting	detargeting	NN
cord-283382-t890r7xp	379	12	on	on	IN
cord-283382-t890r7xp	379	13	adenovirus	adenovirus	NN
cord-283382-t890r7xp	379	14	-	-	HYPH
cord-283382-t890r7xp	379	15	mediated	mediate	VBN
cord-283382-t890r7xp	379	16	innate	innate	JJ
cord-283382-t890r7xp	379	17	and	and	CC
cord-283382-t890r7xp	379	18	adaptive	adaptive	JJ
cord-283382-t890r7xp	379	19	immune	immune	JJ
cord-283382-t890r7xp	379	20	activation	activation	NN
cord-283382-t890r7xp	379	21	Molecular	molecular	JJ
cord-283382-t890r7xp	379	22	cloning	cloning	NN
cord-283382-t890r7xp	379	23	of	of	IN
cord-283382-t890r7xp	379	24	rat	rat	NN
cord-283382-t890r7xp	379	25	and	and	CC
cord-283382-t890r7xp	379	26	mouse	mouse	NN
cord-283382-t890r7xp	379	27	membrane	membrane	NN
cord-283382-t890r7xp	379	28	cofactor	cofactor	NN
cord-283382-t890r7xp	379	29	protein	protein	NN
cord-283382-t890r7xp	379	30	(	(	-LRB-
cord-283382-t890r7xp	379	31	MCP	MCP	NNP
cord-283382-t890r7xp	379	32	,	,	,
cord-283382-t890r7xp	379	33	CD46	CD46	NNP
cord-283382-t890r7xp	379	34	)	)	-RRB-
cord-283382-t890r7xp	379	35	:	:	:
cord-283382-t890r7xp	379	36	preferential	preferential	JJ
cord-283382-t890r7xp	379	37	expression	expression	NN
cord-283382-t890r7xp	379	38	in	in	IN
cord-283382-t890r7xp	379	39	testis	testis	NN
cord-283382-t890r7xp	379	40	and	and	CC
cord-283382-t890r7xp	379	41	close	close	JJ
cord-283382-t890r7xp	379	42	linkage	linkage	NN
cord-283382-t890r7xp	379	43	between	between	IN
cord-283382-t890r7xp	379	44	the	the	DT
cord-283382-t890r7xp	379	45	mouse	mouse	NN
cord-283382-t890r7xp	379	46	Mcp	Mcp	NNP
cord-283382-t890r7xp	379	47	and	and	CC
cord-283382-t890r7xp	379	48	Cr2	cr2	NN
cord-283382-t890r7xp	379	49	genes	gene	NNS
cord-283382-t890r7xp	379	50	on	on	IN
cord-283382-t890r7xp	379	51	distal	distal	JJ
cord-283382-t890r7xp	379	52	chromosome	chromosome	NN
cord-283382-t890r7xp	379	53	1	1	CD
cord-283382-t890r7xp	379	54	Immunogenicity	Immunogenicity	NNP
cord-283382-t890r7xp	379	55	of	of	IN
cord-283382-t890r7xp	379	56	recombinant	recombinant	JJ
cord-283382-t890r7xp	379	57	fiber	fiber	NN
cord-283382-t890r7xp	379	58	-	-	HYPH
cord-283382-t890r7xp	379	59	chimeric	chimeric	JJ
cord-283382-t890r7xp	379	60	adenovirus	adenovirus	NN
cord-283382-t890r7xp	379	61	serotype	serotype	NN
cord-283382-t890r7xp	379	62	35	35	CD
cord-283382-t890r7xp	379	63	vector	vector	NN
cord-283382-t890r7xp	379	64	-	-	HYPH
cord-283382-t890r7xp	379	65	based	base	VBN
cord-283382-t890r7xp	379	66	vaccines	vaccine	NNS
cord-283382-t890r7xp	379	67	in	in	IN
cord-283382-t890r7xp	379	68	mice	mouse	NNS
cord-283382-t890r7xp	379	69	and	and	CC
cord-283382-t890r7xp	379	70	rhesus	rhesu	NNS
cord-283382-t890r7xp	379	71	monkeys	monkey	NNS
cord-283382-t890r7xp	379	72	Inhibition	Inhibition	NNP
cord-283382-t890r7xp	379	73	of	of	IN
cord-283382-t890r7xp	379	74	type	type	NN
cord-283382-t890r7xp	380	1	I	-PRON-	PRP
cord-283382-t890r7xp	381	1	interferon	interferon	NN
cord-283382-t890r7xp	381	2	responses	response	NNS
cord-283382-t890r7xp	381	3	by	by	IN
cord-283382-t890r7xp	381	4	adenovirus	adenovirus	NN
cord-283382-t890r7xp	381	5	serotype	serotype	NN
cord-283382-t890r7xp	381	6	-	-	HYPH
cord-283382-t890r7xp	381	7	dependent	dependent	JJ
cord-283382-t890r7xp	381	8	Gas6	Gas6	NNP
cord-283382-t890r7xp	381	9	binding	bind	VBG
cord-283382-t890r7xp	381	10	Potent	potent	JJ
cord-283382-t890r7xp	381	11	immune	immune	JJ
cord-283382-t890r7xp	381	12	responses	response	NNS
cord-283382-t890r7xp	381	13	and	and	CC
cord-283382-t890r7xp	381	14	in	in	IN
cord-283382-t890r7xp	381	15	vitro	vitro	FW
cord-283382-t890r7xp	381	16	pro	pro	JJ
cord-283382-t890r7xp	381	17	-	-	JJ
cord-283382-t890r7xp	381	18	inflammatory	inflammatory	JJ
cord-283382-t890r7xp	381	19	cytokine	cytokine	NN
cord-283382-t890r7xp	381	20	suppression	suppression	NN
cord-283382-t890r7xp	381	21	by	by	IN
cord-283382-t890r7xp	381	22	a	a	DT
cord-283382-t890r7xp	381	23	novel	novel	JJ
cord-283382-t890r7xp	381	24	adenovirus	adenovirus	NN
cord-283382-t890r7xp	381	25	vaccine	vaccine	NN
cord-283382-t890r7xp	381	26	vector	vector	NN
cord-283382-t890r7xp	381	27	based	base	VBN
cord-283382-t890r7xp	381	28	on	on	IN
cord-283382-t890r7xp	381	29	rare	rare	JJ
cord-283382-t890r7xp	381	30	human	human	JJ
cord-283382-t890r7xp	381	31	serotype	serotype	NN
cord-283382-t890r7xp	381	32	28	28	CD
cord-283382-t890r7xp	381	33	Activation	Activation	NNP
cord-283382-t890r7xp	381	34	of	of	IN
cord-283382-t890r7xp	381	35	p38	p38	NNP
cord-283382-t890r7xp	381	36	and	and	CC
cord-283382-t890r7xp	381	37	ERK	ERK	NNP
cord-283382-t890r7xp	381	38	signaling	signal	VBG
cord-283382-t890r7xp	381	39	during	during	IN
cord-283382-t890r7xp	381	40	adenovirus	adenovirus	NN
cord-283382-t890r7xp	381	41	vector	vector	NN
cord-283382-t890r7xp	381	42	cell	cell	NN
cord-283382-t890r7xp	381	43	entry	entry	NN
cord-283382-t890r7xp	381	44	lead	lead	NN
cord-283382-t890r7xp	381	45	to	to	IN
cord-283382-t890r7xp	381	46	expression	expression	NN
cord-283382-t890r7xp	381	47	of	of	IN
cord-283382-t890r7xp	381	48	the	the	DT
cord-283382-t890r7xp	381	49	C	C	NNP
cord-283382-t890r7xp	381	50	-	-	HYPH
cord-283382-t890r7xp	381	51	X	x	NN
cord-283382-t890r7xp	381	52	-	-	HYPH
cord-283382-t890r7xp	381	53	C	c	NN
cord-283382-t890r7xp	381	54	chemokine	chemokine	NN
cord-283382-t890r7xp	381	55	IP-10	IP-10	NNP
cord-283382-t890r7xp	382	1	The	the	DT
cord-283382-t890r7xp	382	2	potential	potential	NN
cord-283382-t890r7xp	382	3	of	of	IN
cord-283382-t890r7xp	382	4	adenoviral	adenoviral	JJ
cord-283382-t890r7xp	382	5	vaccine	vaccine	NN
cord-283382-t890r7xp	382	6	vectors	vector	NNS
cord-283382-t890r7xp	382	7	with	with	IN
cord-283382-t890r7xp	382	8	altered	altered	JJ
cord-283382-t890r7xp	382	9	antigen	antigen	NN
cord-283382-t890r7xp	382	10	presentation	presentation	NN
cord-283382-t890r7xp	382	11	capabilities	capability	NNS
cord-283382-t890r7xp	382	12	Rapid	Rapid	NNP
cord-283382-t890r7xp	382	13	and	and	CC
cord-283382-t890r7xp	382	14	sustained	sustain	VBD
cord-283382-t890r7xp	382	15	CD4(+	CD4(+	NNP
cord-283382-t890r7xp	382	16	)	)	-RRB-
cord-283382-t890r7xp	382	17	T	t	NN
cord-283382-t890r7xp	382	18	-	-	HYPH
cord-283382-t890r7xp	382	19	cell	cell	NN
cord-283382-t890r7xp	382	20	-	-	HYPH
cord-283382-t890r7xp	382	21	independent	independent	JJ
cord-283382-t890r7xp	382	22	immunity	immunity	NN
cord-283382-t890r7xp	382	23	from	from	IN
cord-283382-t890r7xp	382	24	adenovirus	adenovirus	NN
cord-283382-t890r7xp	382	25	-	-	HYPH
cord-283382-t890r7xp	382	26	encoded	encode	VBN
cord-283382-t890r7xp	382	27	vaccine	vaccine	NN
cord-283382-t890r7xp	382	28	antigens	antigen	NNS
cord-283382-t890r7xp	382	29	Enhanced	enhance	VBN
cord-283382-t890r7xp	382	30	and	and	CC
cord-283382-t890r7xp	382	31	sustained	sustain	VBD
cord-283382-t890r7xp	382	32	CD8	CD8	NNP
cord-283382-t890r7xp	382	33	+	+	CC
cord-283382-t890r7xp	382	34	T	T	NNP
cord-283382-t890r7xp	382	35	cell	cell	NN
cord-283382-t890r7xp	382	36	responses	response	NNS
cord-283382-t890r7xp	382	37	with	with	IN
cord-283382-t890r7xp	382	38	an	an	DT
cord-283382-t890r7xp	382	39	adenoviral	adenoviral	JJ
cord-283382-t890r7xp	382	40	vector	vector	NN
cord-283382-t890r7xp	382	41	-	-	HYPH
cord-283382-t890r7xp	382	42	based	base	VBN
cord-283382-t890r7xp	382	43	hepatitis	hepatitis	NN
cord-283382-t890r7xp	382	44	C	C	NNP
cord-283382-t890r7xp	382	45	virus	virus	NN
cord-283382-t890r7xp	382	46	vaccine	vaccine	NN
cord-283382-t890r7xp	382	47	encoding	encoding	NN
cord-283382-t890r7xp	382	48	NS3	ns3	RB
cord-283382-t890r7xp	382	49	linked	link	VBN
cord-283382-t890r7xp	382	50	to	to	IN
cord-283382-t890r7xp	382	51	the	the	DT
cord-283382-t890r7xp	382	52	MHC	MHC	NNP
cord-283382-t890r7xp	382	53	class	class	NN
cord-283382-t890r7xp	382	54	II	II	NNP
cord-283382-t890r7xp	382	55	chaperone	chaperone	NN
cord-283382-t890r7xp	382	56	protein	protein	NN
cord-283382-t890r7xp	382	57	invariant	invariant	JJ
cord-283382-t890r7xp	382	58	chain	chain	NN
cord-283382-t890r7xp	382	59	Enhanced	enhanced	JJ
cord-283382-t890r7xp	382	60	vaccine	vaccine	NN
cord-283382-t890r7xp	382	61	-	-	HYPH
cord-283382-t890r7xp	382	62	induced	induce	VBN
cord-283382-t890r7xp	382	63	CD8	CD8	NNP
cord-283382-t890r7xp	382	64	+	+	CC
cord-283382-t890r7xp	382	65	T	T	NNP
cord-283382-t890r7xp	382	66	cell	cell	NN
cord-283382-t890r7xp	382	67	responses	response	NNS
cord-283382-t890r7xp	382	68	to	to	IN
cord-283382-t890r7xp	382	69	malaria	malaria	NN
cord-283382-t890r7xp	382	70	antigen	antigen	NN
cord-283382-t890r7xp	382	71	ME	ME	NNP
cord-283382-t890r7xp	382	72	-	-	HYPH
cord-283382-t890r7xp	382	73	TRAP	trap	NN
cord-283382-t890r7xp	382	74	by	by	IN
cord-283382-t890r7xp	382	75	fusion	fusion	NN
cord-283382-t890r7xp	382	76	to	to	IN
cord-283382-t890r7xp	382	77	MHC	MHC	NNP
cord-283382-t890r7xp	382	78	class	class	NN
cord-283382-t890r7xp	382	79	ii	ii	NN
cord-283382-t890r7xp	382	80	invariant	invariant	JJ
cord-283382-t890r7xp	382	81	chain	chain	NN
cord-283382-t890r7xp	382	82	Adenovirus	Adenovirus	NNP
cord-283382-t890r7xp	382	83	-	-	HYPH
cord-283382-t890r7xp	382	84	based	base	VBN
cord-283382-t890r7xp	382	85	vaccine	vaccine	NN
cord-283382-t890r7xp	382	86	against	against	IN
cord-283382-t890r7xp	382	87	listeria	listeria	NNP
cord-283382-t890r7xp	382	88	monocytogenes	monocytogenes	NNP
cord-283382-t890r7xp	382	89	:	:	:
cord-283382-t890r7xp	382	90	extending	extend	VBG
cord-283382-t890r7xp	382	91	the	the	DT
cord-283382-t890r7xp	382	92	concept	concept	NN
cord-283382-t890r7xp	382	93	of	of	IN
cord-283382-t890r7xp	382	94	invariant	invariant	JJ
cord-283382-t890r7xp	382	95	chain	chain	NN
cord-283382-t890r7xp	382	96	linkage	linkage	NN
cord-283382-t890r7xp	382	97	Development	development	NN
cord-283382-t890r7xp	382	98	of	of	IN
cord-283382-t890r7xp	382	99	a	a	DT
cord-283382-t890r7xp	382	100	molecular	molecular	JJ
cord-283382-t890r7xp	382	101	adjuvant	adjuvant	NN
cord-283382-t890r7xp	382	102	to	to	TO
cord-283382-t890r7xp	382	103	enhance	enhance	VB
cord-283382-t890r7xp	382	104	antigen	antigen	NN
cord-283382-t890r7xp	382	105	-	-	HYPH
cord-283382-t890r7xp	382	106	specific	specific	JJ
cord-283382-t890r7xp	382	107	CD8(+	CD8(+	NNS
cord-283382-t890r7xp	382	108	)	)	-RRB-
cord-283382-t890r7xp	383	1	T	T	NNP
cord-283382-t890r7xp	383	2	cell	cell	NN
cord-283382-t890r7xp	383	3	responses	response	NNS
cord-283382-t890r7xp	383	4	Immune	immune	VBP
cord-283382-t890r7xp	383	5	protection	protection	NN
cord-283382-t890r7xp	383	6	of	of	IN
cord-283382-t890r7xp	383	7	nonhuman	nonhuman	NN
cord-283382-t890r7xp	383	8	primates	primate	NNS
cord-283382-t890r7xp	383	9	against	against	IN
cord-283382-t890r7xp	383	10	Ebola	Ebola	NNP
cord-283382-t890r7xp	383	11	virus	virus	NN
cord-283382-t890r7xp	383	12	with	with	IN
cord-283382-t890r7xp	383	13	single	single	JJ
cord-283382-t890r7xp	383	14	low	low	JJ
cord-283382-t890r7xp	383	15	-	-	HYPH
cord-283382-t890r7xp	383	16	dose	dose	NN
cord-283382-t890r7xp	383	17	adenovirus	adenovirus	NN
cord-283382-t890r7xp	383	18	vectors	vector	NNS
cord-283382-t890r7xp	383	19	encoding	encode	VBG
cord-283382-t890r7xp	383	20	modified	modify	VBN
cord-283382-t890r7xp	383	21	GPs	GPs	NNP
cord-283382-t890r7xp	383	22	Efficacy	Efficacy	NNP
cord-283382-t890r7xp	383	23	assessment	assessment	NN
cord-283382-t890r7xp	383	24	of	of	IN
cord-283382-t890r7xp	383	25	a	a	DT
cord-283382-t890r7xp	383	26	cell	cell	NN
cord-283382-t890r7xp	383	27	-	-	HYPH
cord-283382-t890r7xp	383	28	mediated	mediate	VBN
cord-283382-t890r7xp	383	29	immunity	immunity	NN
cord-283382-t890r7xp	383	30	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	383	31	vaccine	vaccine	NN
cord-283382-t890r7xp	383	32	(	(	-LRB-
cord-283382-t890r7xp	383	33	the	the	DT
cord-283382-t890r7xp	383	34	Step	Step	NNP
cord-283382-t890r7xp	383	35	Study	Study	NNP
cord-283382-t890r7xp	383	36	)	)	-RRB-
cord-283382-t890r7xp	383	37	:	:	:
cord-283382-t890r7xp	383	38	a	a	DT
cord-283382-t890r7xp	383	39	double	double	JJ
cord-283382-t890r7xp	383	40	-	-	HYPH
cord-283382-t890r7xp	383	41	blind	blind	JJ
cord-283382-t890r7xp	383	42	,	,	,
cord-283382-t890r7xp	383	43	randomised	randomised	JJ
cord-283382-t890r7xp	383	44	,	,	,
cord-283382-t890r7xp	383	45	placebo	placebo	NN
cord-283382-t890r7xp	383	46	-	-	HYPH
cord-283382-t890r7xp	383	47	controlled	control	VBN
cord-283382-t890r7xp	383	48	,	,	,
cord-283382-t890r7xp	383	49	test	test	NN
cord-283382-t890r7xp	383	50	-	-	HYPH
cord-283382-t890r7xp	383	51	of	of	IN
cord-283382-t890r7xp	383	52	-	-	HYPH
cord-283382-t890r7xp	383	53	concept	concept	NN
cord-283382-t890r7xp	383	54	trial	trial	NN
cord-283382-t890r7xp	383	55	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	383	56	vaccine	vaccine	NN
cord-283382-t890r7xp	383	57	-	-	HYPH
cord-283382-t890r7xp	383	58	induced	induce	VBN
cord-283382-t890r7xp	383	59	immunity	immunity	NN
cord-283382-t890r7xp	383	60	in	in	IN
cord-283382-t890r7xp	383	61	the	the	DT
cord-283382-t890r7xp	383	62	test	test	NN
cord-283382-t890r7xp	383	63	-	-	HYPH
cord-283382-t890r7xp	383	64	of	of	IN
cord-283382-t890r7xp	383	65	-	-	HYPH
cord-283382-t890r7xp	383	66	concept	concept	NN
cord-283382-t890r7xp	383	67	Step	Step	NNP
cord-283382-t890r7xp	383	68	Study	Study	NNP
cord-283382-t890r7xp	383	69	:	:	:
cord-283382-t890r7xp	383	70	a	a	DT
cord-283382-t890r7xp	383	71	case	case	NN
cord-283382-t890r7xp	383	72	-	-	HYPH
cord-283382-t890r7xp	383	73	cohort	cohort	NN
cord-283382-t890r7xp	383	74	analysis	analysis	NN
cord-283382-t890r7xp	383	75	Safety	safety	NN
cord-283382-t890r7xp	383	76	and	and	CC
cord-283382-t890r7xp	383	77	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	383	78	of	of	IN
cord-283382-t890r7xp	383	79	a	a	DT
cord-283382-t890r7xp	383	80	replication	replication	NN
cord-283382-t890r7xp	383	81	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	383	82	clade	clade	NN
cord-283382-t890r7xp	383	83	B	B	NNP
cord-283382-t890r7xp	383	84	gag	gag	NN
cord-283382-t890r7xp	383	85	/	/	SYM
cord-283382-t890r7xp	383	86	pol	pol	NN
cord-283382-t890r7xp	383	87	/	/	SYM
cord-283382-t890r7xp	383	88	nef	nef	NNP
cord-283382-t890r7xp	383	89	vaccine	vaccine	NN
cord-283382-t890r7xp	383	90	in	in	IN
cord-283382-t890r7xp	383	91	healthy	healthy	JJ
cord-283382-t890r7xp	383	92	adults	adult	NNS
cord-283382-t890r7xp	383	93	Activation	Activation	NNP
cord-283382-t890r7xp	383	94	of	of	IN
cord-283382-t890r7xp	383	95	a	a	DT
cord-283382-t890r7xp	383	96	dendritic	dendritic	JJ
cord-283382-t890r7xp	383	97	cell	cell	NN
cord-283382-t890r7xp	383	98	-	-	HYPH
cord-283382-t890r7xp	383	99	T	t	NN
cord-283382-t890r7xp	383	100	cell	cell	NN
cord-283382-t890r7xp	383	101	axis	axis	NN
cord-283382-t890r7xp	383	102	by	by	IN
cord-283382-t890r7xp	383	103	Ad5	ad5	CD
cord-283382-t890r7xp	383	104	immune	immune	JJ
cord-283382-t890r7xp	383	105	complexes	complex	NNS
cord-283382-t890r7xp	383	106	creates	create	VBZ
cord-283382-t890r7xp	383	107	an	an	DT
cord-283382-t890r7xp	383	108	improved	improved	JJ
cord-283382-t890r7xp	383	109	environment	environment	NN
cord-283382-t890r7xp	383	110	for	for	IN
cord-283382-t890r7xp	383	111	replication	replication	NN
cord-283382-t890r7xp	383	112	of	of	IN
cord-283382-t890r7xp	383	113	HIV	HIV	NNP
cord-283382-t890r7xp	383	114	in	in	IN
cord-283382-t890r7xp	383	115	T	T	NNP
cord-283382-t890r7xp	383	116	cells	cell	NNS
cord-283382-t890r7xp	384	1	Adenovirus	Adenovirus	NNP
cord-283382-t890r7xp	384	2	vector	vector	NN
cord-283382-t890r7xp	384	3	vaccination	vaccination	NN
cord-283382-t890r7xp	384	4	induces	induce	VBZ
cord-283382-t890r7xp	384	5	expansion	expansion	NN
cord-283382-t890r7xp	384	6	of	of	IN
cord-283382-t890r7xp	384	7	memory	memory	NN
cord-283382-t890r7xp	384	8	CD4	CD4	NNP
cord-283382-t890r7xp	384	9	T	T	NNP
cord-283382-t890r7xp	384	10	cells	cell	NNS
cord-283382-t890r7xp	384	11	with	with	IN
cord-283382-t890r7xp	384	12	a	a	DT
cord-283382-t890r7xp	384	13	mucosal	mucosal	JJ
cord-283382-t890r7xp	384	14	homing	homing	NN
cord-283382-t890r7xp	384	15	phenotype	phenotype	NN
cord-283382-t890r7xp	384	16	that	that	WDT
cord-283382-t890r7xp	384	17	are	be	VBP
cord-283382-t890r7xp	384	18	readily	readily	RB
cord-283382-t890r7xp	384	19	susceptible	susceptible	JJ
cord-283382-t890r7xp	384	20	to	to	IN
cord-283382-t890r7xp	384	21	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	384	22	Adenovirus	Adenovirus	NNP
cord-283382-t890r7xp	384	23	-	-	HYPH
cord-283382-t890r7xp	384	24	specific	specific	JJ
cord-283382-t890r7xp	384	25	immunity	immunity	NN
cord-283382-t890r7xp	384	26	after	after	IN
cord-283382-t890r7xp	384	27	immunization	immunization	NN
cord-283382-t890r7xp	384	28	with	with	IN
cord-283382-t890r7xp	384	29	an	an	DT
cord-283382-t890r7xp	384	30	Ad5	Ad5	NNP
cord-283382-t890r7xp	384	31	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	384	32	vaccine	vaccine	NN
cord-283382-t890r7xp	384	33	candidate	candidate	NN
cord-283382-t890r7xp	384	34	in	in	IN
cord-283382-t890r7xp	384	35	humans	human	NNS
cord-283382-t890r7xp	385	1	Extended	extend	VBN
cord-283382-t890r7xp	385	2	follow	follow	NN
cord-283382-t890r7xp	385	3	-	-	HYPH
cord-283382-t890r7xp	385	4	up	up	NN
cord-283382-t890r7xp	385	5	confirms	confirm	VBZ
cord-283382-t890r7xp	385	6	early	early	JJ
cord-283382-t890r7xp	385	7	vaccine	vaccine	NN
cord-283382-t890r7xp	385	8	-	-	HYPH
cord-283382-t890r7xp	385	9	enhanced	enhance	VBN
cord-283382-t890r7xp	385	10	risk	risk	NN
cord-283382-t890r7xp	385	11	of	of	IN
cord-283382-t890r7xp	385	12	HIV	HIV	NNP
cord-283382-t890r7xp	385	13	acquisition	acquisition	NN
cord-283382-t890r7xp	385	14	and	and	CC
cord-283382-t890r7xp	385	15	demonstrates	demonstrate	VBZ
cord-283382-t890r7xp	385	16	waning	wane	VBG
cord-283382-t890r7xp	385	17	effect	effect	NN
cord-283382-t890r7xp	385	18	over	over	IN
cord-283382-t890r7xp	385	19	time	time	NN
cord-283382-t890r7xp	385	20	among	among	IN
cord-283382-t890r7xp	385	21	participants	participant	NNS
cord-283382-t890r7xp	385	22	in	in	IN
cord-283382-t890r7xp	385	23	a	a	DT
cord-283382-t890r7xp	385	24	randomized	randomized	JJ
cord-283382-t890r7xp	385	25	trial	trial	NN
cord-283382-t890r7xp	385	26	of	of	IN
cord-283382-t890r7xp	385	27	recombinant	recombinant	JJ
cord-283382-t890r7xp	385	28	adenovirus	adenovirus	NN
cord-283382-t890r7xp	385	29	HIV	HIV	NNP
cord-283382-t890r7xp	385	30	vaccine	vaccine	NN
cord-283382-t890r7xp	385	31	(	(	-LRB-
cord-283382-t890r7xp	385	32	Step	Step	NNP
cord-283382-t890r7xp	385	33	Study	Study	NNP
cord-283382-t890r7xp	385	34	)	)	-RRB-
cord-283382-t890r7xp	386	1	A	a	DT
cord-283382-t890r7xp	386	2	novel	novel	JJ
cord-283382-t890r7xp	386	3	adenovirus	adenovirus	NN
cord-283382-t890r7xp	386	4	type	type	NN
cord-283382-t890r7xp	386	5	6	6	CD
cord-283382-t890r7xp	387	1	(	(	-LRB-
cord-283382-t890r7xp	387	2	Ad6)-based	ad6)-based	JJ
cord-283382-t890r7xp	387	3	hepatitis	hepatitis	NN
cord-283382-t890r7xp	387	4	C	c	NN
cord-283382-t890r7xp	387	5	virus	virus	NN
cord-283382-t890r7xp	387	6	vector	vector	NN
cord-283382-t890r7xp	387	7	that	that	WDT
cord-283382-t890r7xp	387	8	overcomes	overcome	VBZ
cord-283382-t890r7xp	387	9	preexisting	preexist	VBG
cord-283382-t890r7xp	387	10	anti	anti	JJ
cord-283382-t890r7xp	387	11	-	-	JJ
cord-283382-t890r7xp	387	12	ad5	ad5	JJ
cord-283382-t890r7xp	387	13	immunity	immunity	NN
cord-283382-t890r7xp	387	14	and	and	CC
cord-283382-t890r7xp	387	15	induces	induce	VBZ
cord-283382-t890r7xp	387	16	potent	potent	JJ
cord-283382-t890r7xp	387	17	and	and	CC
cord-283382-t890r7xp	387	18	broad	broad	JJ
cord-283382-t890r7xp	387	19	cellular	cellular	JJ
cord-283382-t890r7xp	387	20	immune	immune	JJ
cord-283382-t890r7xp	387	21	responses	response	NNS
cord-283382-t890r7xp	387	22	in	in	IN
cord-283382-t890r7xp	387	23	rhesus	rhesu	NNS
cord-283382-t890r7xp	387	24	macaques	macaque	NNS
cord-283382-t890r7xp	387	25	Safety	safety	NN
cord-283382-t890r7xp	387	26	and	and	CC
cord-283382-t890r7xp	387	27	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	387	28	of	of	IN
cord-283382-t890r7xp	387	29	the	the	DT
cord-283382-t890r7xp	387	30	Merck	Merck	NNP
cord-283382-t890r7xp	387	31	adenovirus	adenovirus	NN
cord-283382-t890r7xp	387	32	serotype	serotype	NN
cord-283382-t890r7xp	387	33	5	5	CD
cord-283382-t890r7xp	387	34	(	(	-LRB-
cord-283382-t890r7xp	387	35	MRKAd5	mrkad5	NN
cord-283382-t890r7xp	387	36	)	)	-RRB-
cord-283382-t890r7xp	387	37	and	and	CC
cord-283382-t890r7xp	387	38	MRKAd6	MRKAd6	NNP
cord-283382-t890r7xp	387	39	human	human	JJ
cord-283382-t890r7xp	387	40	immunodeficiency	immunodeficiency	NN
cord-283382-t890r7xp	387	41	virus	virus	NN
cord-283382-t890r7xp	387	42	type	type	NN
cord-283382-t890r7xp	387	43	1	1	CD
cord-283382-t890r7xp	387	44	trigene	trigene	NN
cord-283382-t890r7xp	387	45	vaccines	vaccine	NNS
cord-283382-t890r7xp	387	46	alone	alone	RB
cord-283382-t890r7xp	387	47	and	and	CC
cord-283382-t890r7xp	387	48	in	in	IN
cord-283382-t890r7xp	387	49	combination	combination	NN
cord-283382-t890r7xp	387	50	in	in	IN
cord-283382-t890r7xp	387	51	healthy	healthy	JJ
cord-283382-t890r7xp	387	52	adults	adult	NNS
cord-283382-t890r7xp	388	1	Novel	novel	JJ
cord-283382-t890r7xp	388	2	genetically	genetically	RB
cord-283382-t890r7xp	388	3	-	-	HYPH
cord-283382-t890r7xp	388	4	modified	modify	VBN
cord-283382-t890r7xp	388	5	chimpanzee	chimpanzee	NN
cord-283382-t890r7xp	388	6	adenovirus	adenovirus	NN
cord-283382-t890r7xp	388	7	and	and	CC
cord-283382-t890r7xp	388	8	MVAvectored	mvavectored	JJ
cord-283382-t890r7xp	388	9	respiratory	respiratory	JJ
cord-283382-t890r7xp	388	10	syncytial	syncytial	JJ
cord-283382-t890r7xp	388	11	virus	virus	NN
cord-283382-t890r7xp	388	12	vaccine	vaccine	NN
cord-283382-t890r7xp	388	13	safely	safely	RB
cord-283382-t890r7xp	388	14	boosts	boost	VBZ
cord-283382-t890r7xp	388	15	humoral	humoral	JJ
cord-283382-t890r7xp	388	16	and	and	CC
cord-283382-t890r7xp	388	17	cellular	cellular	JJ
cord-283382-t890r7xp	388	18	immunity	immunity	NN
cord-283382-t890r7xp	388	19	in	in	IN
cord-283382-t890r7xp	388	20	healthy	healthy	JJ
cord-283382-t890r7xp	388	21	older	old	JJR
cord-283382-t890r7xp	388	22	adults	adult	NNS
cord-283382-t890r7xp	388	23	Safety	safety	NN
cord-283382-t890r7xp	388	24	and	and	CC
cord-283382-t890r7xp	388	25	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	388	26	of	of	IN
cord-283382-t890r7xp	388	27	malaria	malaria	NN
cord-283382-t890r7xp	388	28	vectored	vectore	VBN
cord-283382-t890r7xp	388	29	vaccines	vaccine	NNS
cord-283382-t890r7xp	388	30	given	give	VBN
cord-283382-t890r7xp	388	31	with	with	IN
cord-283382-t890r7xp	388	32	routine	routine	JJ
cord-283382-t890r7xp	388	33	expanded	expand	VBN
cord-283382-t890r7xp	388	34	program	program	NN
cord-283382-t890r7xp	388	35	on	on	IN
cord-283382-t890r7xp	388	36	immunization	immunization	NN
cord-283382-t890r7xp	388	37	vaccines	vaccine	NNS
cord-283382-t890r7xp	388	38	in	in	IN
cord-283382-t890r7xp	388	39	Gambian	gambian	JJ
cord-283382-t890r7xp	388	40	infants	infant	NNS
cord-283382-t890r7xp	388	41	and	and	CC
cord-283382-t890r7xp	388	42	neonates	neonate	NNS
cord-283382-t890r7xp	388	43	:	:	:
cord-283382-t890r7xp	388	44	a	a	DT
cord-283382-t890r7xp	388	45	randomized	randomized	JJ
cord-283382-t890r7xp	388	46	controlled	control	VBN
cord-283382-t890r7xp	388	47	trial	trial	NN
cord-283382-t890r7xp	388	48	.	.	.
cord-283382-t890r7xp	389	1	Front	Front	NNP
cord-283382-t890r7xp	389	2	Immunol	Immunol	NNP
cord-283382-t890r7xp	389	3	Viral	Viral	NNP
cord-283382-t890r7xp	389	4	Vector	Vector	NNP
cord-283382-t890r7xp	389	5	malaria	malaria	NN
cord-283382-t890r7xp	389	6	vaccines	vaccine	NNS
cord-283382-t890r7xp	389	7	induce	induce	VBP
cord-283382-t890r7xp	389	8	high	high	JJ
cord-283382-t890r7xp	389	9	-	-	HYPH
cord-283382-t890r7xp	389	10	level	level	NN
cord-283382-t890r7xp	389	11	T	t	NN
cord-283382-t890r7xp	389	12	cell	cell	NN
cord-283382-t890r7xp	389	13	and	and	CC
cord-283382-t890r7xp	389	14	antibody	antibody	NN
cord-283382-t890r7xp	389	15	responses	response	NNS
cord-283382-t890r7xp	389	16	in	in	IN
cord-283382-t890r7xp	389	17	West	west	JJ
cord-283382-t890r7xp	389	18	African	african	JJ
cord-283382-t890r7xp	389	19	children	child	NNS
cord-283382-t890r7xp	389	20	and	and	CC
cord-283382-t890r7xp	389	21	infants	infant	NNS
cord-283382-t890r7xp	389	22	Assessment	Assessment	NNP
cord-283382-t890r7xp	389	23	of	of	IN
cord-283382-t890r7xp	389	24	novel	novel	JJ
cord-283382-t890r7xp	389	25	vaccination	vaccination	NN
cord-283382-t890r7xp	389	26	regimens	regimen	NNS
cord-283382-t890r7xp	389	27	using	use	VBG
cord-283382-t890r7xp	389	28	viral	viral	JJ
cord-283382-t890r7xp	389	29	vectored	vectore	VBN
cord-283382-t890r7xp	389	30	liver	liver	NN
cord-283382-t890r7xp	389	31	stage	stage	NN
cord-283382-t890r7xp	389	32	malaria	malaria	NN
cord-283382-t890r7xp	389	33	vaccines	vaccine	NNS
cord-283382-t890r7xp	389	34	encoding	encode	VBG
cord-283382-t890r7xp	389	35	ME	ME	NNP
cord-283382-t890r7xp	389	36	-	-	HYPH
cord-283382-t890r7xp	389	37	TRAP	trap	NN
cord-283382-t890r7xp	389	38	Safety	Safety	NNP
cord-283382-t890r7xp	389	39	and	and	CC
cord-283382-t890r7xp	389	40	Immunogenicity	Immunogenicity	NNP
cord-283382-t890r7xp	389	41	of	of	IN
cord-283382-t890r7xp	389	42	ChAd63	ChAd63	NNP
cord-283382-t890r7xp	389	43	and	and	CC
cord-283382-t890r7xp	389	44	MVA	MVA	NNP
cord-283382-t890r7xp	389	45	ME	ME	NNP
cord-283382-t890r7xp	389	46	-	-	HYPH
cord-283382-t890r7xp	389	47	TRAP	trap	NN
cord-283382-t890r7xp	389	48	in	in	IN
cord-283382-t890r7xp	389	49	West	west	JJ
cord-283382-t890r7xp	389	50	African	african	JJ
cord-283382-t890r7xp	389	51	children	child	NNS
cord-283382-t890r7xp	389	52	and	and	CC
cord-283382-t890r7xp	389	53	infants	infant	NNS
cord-283382-t890r7xp	389	54	Evaluation	Evaluation	NNP
cord-283382-t890r7xp	389	55	of	of	IN
cord-283382-t890r7xp	389	56	the	the	DT
cord-283382-t890r7xp	389	57	efficacy	efficacy	NN
cord-283382-t890r7xp	389	58	of	of	IN
cord-283382-t890r7xp	389	59	ChAd63-MVA	chad63-mva	JJ
cord-283382-t890r7xp	389	60	vectored	vectore	VBN
cord-283382-t890r7xp	389	61	vaccines	vaccine	NNS
cord-283382-t890r7xp	389	62	expressing	express	VBG
cord-283382-t890r7xp	389	63	circumsporozoite	circumsporozoite	JJ
cord-283382-t890r7xp	389	64	protein	protein	NN
cord-283382-t890r7xp	389	65	and	and	CC
cord-283382-t890r7xp	389	66	ME	ME	NNP
cord-283382-t890r7xp	389	67	-	-	HYPH
cord-283382-t890r7xp	389	68	TRAP	trap	NN
cord-283382-t890r7xp	389	69	against	against	IN
cord-283382-t890r7xp	389	70	controlled	control	VBN
cord-283382-t890r7xp	389	71	human	human	JJ
cord-283382-t890r7xp	389	72	malaria	malaria	NN
cord-283382-t890r7xp	389	73	infection	infection	NN
cord-283382-t890r7xp	389	74	in	in	IN
cord-283382-t890r7xp	389	75	malaria	malaria	NN
cord-283382-t890r7xp	389	76	-	-	HYPH
cord-283382-t890r7xp	389	77	naive	naive	JJ
cord-283382-t890r7xp	389	78	individuals	individual	NNS
cord-283382-t890r7xp	389	79	Prime	prime	JJ
cord-283382-t890r7xp	389	80	-	-	HYPH
cord-283382-t890r7xp	389	81	boost	boost	NN
cord-283382-t890r7xp	389	82	vaccination	vaccination	NN
cord-283382-t890r7xp	389	83	with	with	IN
cord-283382-t890r7xp	389	84	chimpanzee	chimpanzee	NN
cord-283382-t890r7xp	389	85	adenovirus	adenovirus	NN
cord-283382-t890r7xp	389	86	and	and	CC
cord-283382-t890r7xp	389	87	modified	modify	VBN
cord-283382-t890r7xp	389	88	vaccinia	vaccinia	NN
cord-283382-t890r7xp	389	89	Ankara	Ankara	NNP
cord-283382-t890r7xp	389	90	encoding	encoding	NN
cord-283382-t890r7xp	389	91	TRAP	trap	NN
cord-283382-t890r7xp	389	92	provides	provide	VBZ
cord-283382-t890r7xp	389	93	partial	partial	JJ
cord-283382-t890r7xp	389	94	protection	protection	NN
cord-283382-t890r7xp	389	95	against	against	IN
cord-283382-t890r7xp	389	96	plasmodium	plasmodium	NN
cord-283382-t890r7xp	389	97	falciparum	falciparum	NN
cord-283382-t890r7xp	389	98	infection	infection	NN
cord-283382-t890r7xp	389	99	in	in	IN
cord-283382-t890r7xp	389	100	Kenyan	kenyan	JJ
cord-283382-t890r7xp	389	101	adults	adult	NNS
cord-283382-t890r7xp	390	1	First	first	JJ
cord-283382-t890r7xp	390	2	field	field	NN
cord-283382-t890r7xp	390	3	efficacy	efficacy	NN
cord-283382-t890r7xp	390	4	trial	trial	NN
cord-283382-t890r7xp	390	5	of	of	IN
cord-283382-t890r7xp	390	6	the	the	DT
cord-283382-t890r7xp	390	7	ChAd63	ChAd63	NNP
cord-283382-t890r7xp	390	8	MVA	MVA	NNP
cord-283382-t890r7xp	390	9	ME	ME	NNP
cord-283382-t890r7xp	390	10	-	-	HYPH
cord-283382-t890r7xp	390	11	TRAP	trap	NN
cord-283382-t890r7xp	390	12	vectored	vectore	VBD
cord-283382-t890r7xp	390	13	malaria	malaria	NN
cord-283382-t890r7xp	390	14	vaccine	vaccine	NN
cord-283382-t890r7xp	390	15	candidate	candidate	NN
cord-283382-t890r7xp	390	16	in	in	IN
cord-283382-t890r7xp	390	17	5	5	CD
cord-283382-t890r7xp	390	18	-	-	SYM
cord-283382-t890r7xp	390	19	17	17	CD
cord-283382-t890r7xp	390	20	months	month	NNS
cord-283382-t890r7xp	390	21	old	old	JJ
cord-283382-t890r7xp	390	22	infants	infant	NNS
cord-283382-t890r7xp	390	23	and	and	CC
cord-283382-t890r7xp	390	24	children	child	NNS
cord-283382-t890r7xp	390	25	A	a	DT
cord-283382-t890r7xp	390	26	prophylactic	prophylactic	JJ
cord-283382-t890r7xp	390	27	multivalent	multivalent	JJ
cord-283382-t890r7xp	390	28	vaccine	vaccine	NN
cord-283382-t890r7xp	390	29	against	against	IN
cord-283382-t890r7xp	390	30	different	different	JJ
cord-283382-t890r7xp	390	31	filovirus	filovirus	NN
cord-283382-t890r7xp	390	32	species	species	NN
cord-283382-t890r7xp	390	33	is	be	VBZ
cord-283382-t890r7xp	390	34	immunogenic	immunogenic	JJ
cord-283382-t890r7xp	390	35	and	and	CC
cord-283382-t890r7xp	390	36	provides	provide	VBZ
cord-283382-t890r7xp	390	37	protection	protection	NN
cord-283382-t890r7xp	390	38	from	from	IN
cord-283382-t890r7xp	390	39	lethal	lethal	JJ
cord-283382-t890r7xp	390	40	infections	infection	NNS
cord-283382-t890r7xp	390	41	with	with	IN
cord-283382-t890r7xp	390	42	Ebolavirus	Ebolavirus	NNP
cord-283382-t890r7xp	390	43	and	and	CC
cord-283382-t890r7xp	390	44	Marburgvirus	Marburgvirus	NNP
cord-283382-t890r7xp	390	45	species	specie	NNS
cord-283382-t890r7xp	390	46	in	in	IN
cord-283382-t890r7xp	390	47	non	non	JJ
cord-283382-t890r7xp	390	48	-	-	JJ
cord-283382-t890r7xp	390	49	human	human	JJ
cord-283382-t890r7xp	390	50	primates	primate	NNS
cord-283382-t890r7xp	390	51	Safety	Safety	NNP
cord-283382-t890r7xp	390	52	and	and	CC
cord-283382-t890r7xp	390	53	Immunogenicity	Immunogenicity	NNP
cord-283382-t890r7xp	390	54	of	of	IN
cord-283382-t890r7xp	390	55	a	a	DT
cord-283382-t890r7xp	390	56	2-dose	2-dose	CD
cord-283382-t890r7xp	390	57	heterologous	heterologous	JJ
cord-283382-t890r7xp	390	58	vaccination	vaccination	NN
cord-283382-t890r7xp	390	59	regimen	regimen	NN
cord-283382-t890r7xp	390	60	with	with	IN
cord-283382-t890r7xp	390	61	Ad26.ZEBOV	Ad26.ZEBOV	NNP
cord-283382-t890r7xp	390	62	and	and	CC
cord-283382-t890r7xp	390	63	MVA	MVA	NNP
cord-283382-t890r7xp	390	64	-	-	HYPH
cord-283382-t890r7xp	390	65	BN	BN	NNP
cord-283382-t890r7xp	390	66	-	-	HYPH
cord-283382-t890r7xp	390	67	Filo	Filo	NNP
cord-283382-t890r7xp	390	68	Ebola	Ebola	NNP
cord-283382-t890r7xp	390	69	vaccines	vaccine	NNS
cord-283382-t890r7xp	390	70	:	:	:
cord-283382-t890r7xp	390	71	12-month	12-month	JJ
cord-283382-t890r7xp	390	72	data	datum	NNS
cord-283382-t890r7xp	390	73	from	from	IN
cord-283382-t890r7xp	390	74	a	a	DT
cord-283382-t890r7xp	390	75	phase	phase	NN
cord-283382-t890r7xp	390	76	1	1	CD
cord-283382-t890r7xp	390	77	randomized	randomized	JJ
cord-283382-t890r7xp	390	78	clinical	clinical	JJ
cord-283382-t890r7xp	390	79	trial	trial	NN
cord-283382-t890r7xp	390	80	in	in	IN
cord-283382-t890r7xp	390	81	Uganda	Uganda	NNP
cord-283382-t890r7xp	390	82	and	and	CC
cord-283382-t890r7xp	390	83	Tanzania	Tanzania	NNP
cord-283382-t890r7xp	390	84	Safety	Safety	NNP
cord-283382-t890r7xp	390	85	and	and	CC
cord-283382-t890r7xp	390	86	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	390	87	of	of	IN
cord-283382-t890r7xp	390	88	novel	novel	JJ
cord-283382-t890r7xp	390	89	adenovirus	adenovirus	NN
cord-283382-t890r7xp	390	90	type	type	NN
cord-283382-t890r7xp	390	91	26-and	26-and	CD
cord-283382-t890r7xp	390	92	modified	modify	VBN
cord-283382-t890r7xp	390	93	vaccinia	vaccinia	NN
cord-283382-t890r7xp	390	94	Ankara	Ankara	NNP
cord-283382-t890r7xp	390	95	-	-	HYPH
cord-283382-t890r7xp	390	96	vectored	vectore	VBN
cord-283382-t890r7xp	390	97	Ebola	Ebola	NNP
cord-283382-t890r7xp	390	98	vaccines	vaccine	NNS
cord-283382-t890r7xp	390	99	:	:	:
cord-283382-t890r7xp	391	1	a	a	DT
cord-283382-t890r7xp	391	2	randomized	randomized	JJ
cord-283382-t890r7xp	391	3	clinical	clinical	JJ
cord-283382-t890r7xp	391	4	trial	trial	NN
cord-283382-t890r7xp	391	5	Adenovectors	Adenovectors	NNP
cord-283382-t890r7xp	391	6	encoding	encode	VBG
cord-283382-t890r7xp	391	7	RSV	RSV	NNP
cord-283382-t890r7xp	391	8	-	-	HYPH
cord-283382-t890r7xp	391	9	F	F	NNP
cord-283382-t890r7xp	391	10	protein	protein	NN
cord-283382-t890r7xp	391	11	induce	induce	VBP
cord-283382-t890r7xp	391	12	durable	durable	JJ
cord-283382-t890r7xp	391	13	and	and	CC
cord-283382-t890r7xp	391	14	mucosal	mucosal	JJ
cord-283382-t890r7xp	391	15	immunity	immunity	NN
cord-283382-t890r7xp	391	16	in	in	IN
cord-283382-t890r7xp	391	17	macaques	macaque	NNS
cord-283382-t890r7xp	391	18	after	after	IN
cord-283382-t890r7xp	391	19	two	two	CD
cord-283382-t890r7xp	391	20	intramuscular	intramuscular	JJ
cord-283382-t890r7xp	391	21	administrations	administration	NNS
cord-283382-t890r7xp	391	22	Firstin	Firstin	NNP
cord-283382-t890r7xp	391	23	-	-	HYPH
cord-283382-t890r7xp	391	24	human	human	JJ
cord-283382-t890r7xp	391	25	evaluation	evaluation	NN
cord-283382-t890r7xp	391	26	of	of	IN
cord-283382-t890r7xp	391	27	the	the	DT
cord-283382-t890r7xp	391	28	safety	safety	NN
cord-283382-t890r7xp	391	29	and	and	CC
cord-283382-t890r7xp	391	30	immunogenicity	immunogenicity	NN
cord-283382-t890r7xp	391	31	of	of	IN
cord-283382-t890r7xp	391	32	a	a	DT
cord-283382-t890r7xp	391	33	recombinant	recombinant	JJ
cord-283382-t890r7xp	391	34	adenovirus	adenovirus	NN
cord-283382-t890r7xp	391	35	serotype	serotype	NN
cord-283382-t890r7xp	391	36	26	26	CD
cord-283382-t890r7xp	391	37	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	391	38	Env	Env	NNP
cord-283382-t890r7xp	391	39	vaccine	vaccine	NN
cord-283382-t890r7xp	391	40	(	(	-LRB-
cord-283382-t890r7xp	391	41	IPCAVD	IPCAVD	NNP
cord-283382-t890r7xp	391	42	001	001	CD
cord-283382-t890r7xp	391	43	)	)	-RRB-
cord-283382-t890r7xp	392	1	Characterization	characterization	NN
cord-283382-t890r7xp	392	2	of	of	IN
cord-283382-t890r7xp	392	3	humoral	humoral	JJ
cord-283382-t890r7xp	392	4	and	and	CC
cord-283382-t890r7xp	392	5	cellular	cellular	JJ
cord-283382-t890r7xp	392	6	immune	immune	JJ
cord-283382-t890r7xp	392	7	responses	response	NNS
cord-283382-t890r7xp	392	8	elicited	elicit	VBN
cord-283382-t890r7xp	392	9	by	by	IN
cord-283382-t890r7xp	392	10	a	a	DT
cord-283382-t890r7xp	392	11	recombinant	recombinant	JJ
cord-283382-t890r7xp	392	12	adenovirus	adenovirus	NN
cord-283382-t890r7xp	392	13	serotype	serotype	NN
cord-283382-t890r7xp	392	14	26	26	CD
cord-283382-t890r7xp	392	15	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	392	16	Env	Env	NNP
cord-283382-t890r7xp	392	17	vaccine	vaccine	NN
cord-283382-t890r7xp	392	18	in	in	IN
cord-283382-t890r7xp	392	19	healthy	healthy	JJ
cord-283382-t890r7xp	392	20	adults	adult	NNS
cord-283382-t890r7xp	392	21	(	(	-LRB-
cord-283382-t890r7xp	392	22	IPCAVD	IPCAVD	NNP
cord-283382-t890r7xp	392	23	001	001	CD
cord-283382-t890r7xp	392	24	)	)	-RRB-
cord-283382-t890r7xp	393	1	Mosaic	Mosaic	NNP
cord-283382-t890r7xp	393	2	HIV-1	HIV-1	NNP
cord-283382-t890r7xp	393	3	vaccines	vaccine	NNS
cord-283382-t890r7xp	393	4	expand	expand	VBP
cord-283382-t890r7xp	393	5	the	the	DT
cord-283382-t890r7xp	393	6	breadth	breadth	NN
cord-283382-t890r7xp	393	7	and	and	CC
cord-283382-t890r7xp	393	8	depth	depth	NN
cord-283382-t890r7xp	393	9	of	of	IN
cord-283382-t890r7xp	393	10	cellular	cellular	JJ
cord-283382-t890r7xp	393	11	immune	immune	JJ
cord-283382-t890r7xp	393	12	responses	response	NNS
cord-283382-t890r7xp	393	13	in	in	IN
cord-283382-t890r7xp	393	14	rhesus	rhesu	NNS
cord-283382-t890r7xp	393	15	monkeys	monkey	NNS
cord-283382-t890r7xp	393	16	Thanks	thank	NNS
cord-283382-t890r7xp	393	17	to	to	IN
cord-283382-t890r7xp	393	18	Prof.	Prof.	NNP
cord-283382-t890r7xp	393	19	Peter	Peter	NNP
cord-283382-t890r7xp	393	20	Palese	Palese	NNP
cord-283382-t890r7xp	393	21	,	,	,
cord-283382-t890r7xp	393	22	ISMMS	ISMMS	NNP
cord-283382-t890r7xp	393	23	,	,	,
cord-283382-t890r7xp	393	24	for	for	IN
cord-283382-t890r7xp	393	25	helpful	helpful	JJ
cord-283382-t890r7xp	393	26	and	and	CC
cord-283382-t890r7xp	393	27	constructive	constructive	JJ
cord-283382-t890r7xp	393	28	discussion	discussion	NN
cord-283382-t890r7xp	393	29	of	of	IN
cord-283382-t890r7xp	393	30	this	this	DT
cord-283382-t890r7xp	393	31	review	review	NN
cord-283382-t890r7xp	393	32	.	.	.
cord-283382-t890r7xp	394	1	Figures	figure	NNS
cord-283382-t890r7xp	394	2	were	be	VBD
cord-283382-t890r7xp	394	3	created	create	VBN
cord-283382-t890r7xp	394	4	with	with	IN
cord-283382-t890r7xp	394	5	©	©	NNP
cord-283382-t890r7xp	394	6	BioRender	BioRender	NNP
cord-283382-t890r7xp	394	7	-biorender.com	-biorender.com	ADD
cord-283382-t890r7xp	394	8	.	.	.
cord-283382-t890r7xp	395	1	The	the	DT
cord-283382-t890r7xp	395	2	author	author	NN
cord-283382-t890r7xp	395	3	declares	declare	VBZ
cord-283382-t890r7xp	395	4	that	that	IN
cord-283382-t890r7xp	395	5	the	the	DT
cord-283382-t890r7xp	395	6	research	research	NN
cord-283382-t890r7xp	395	7	was	be	VBD
cord-283382-t890r7xp	395	8	conducted	conduct	VBN
cord-283382-t890r7xp	395	9	in	in	IN
cord-283382-t890r7xp	395	10	the	the	DT
cord-283382-t890r7xp	395	11	absence	absence	NN
cord-283382-t890r7xp	395	12	of	of	IN
cord-283382-t890r7xp	395	13	any	any	DT
cord-283382-t890r7xp	395	14	commercial	commercial	JJ
cord-283382-t890r7xp	395	15	or	or	CC
cord-283382-t890r7xp	395	16	financial	financial	JJ
cord-283382-t890r7xp	395	17	relationships	relationship	NNS
cord-283382-t890r7xp	395	18	that	that	WDT
cord-283382-t890r7xp	395	19	could	could	MD
cord-283382-t890r7xp	395	20	be	be	VB
cord-283382-t890r7xp	395	21	construed	construe	VBN
cord-283382-t890r7xp	395	22	as	as	IN
cord-283382-t890r7xp	395	23	a	a	DT
cord-283382-t890r7xp	395	24	potential	potential	JJ
cord-283382-t890r7xp	395	25	conflict	conflict	NN
cord-283382-t890r7xp	395	26	of	of	IN
cord-283382-t890r7xp	395	27	interest	interest	NN
cord-283382-t890r7xp	395	28	.	.	.
cord-283382-t890r7xp	396	1	Copyright	copyright	NN
cord-283382-t890r7xp	396	2	©	©	NNP
cord-283382-t890r7xp	396	3	2020	2020	CD
cord-283382-t890r7xp	396	4	Coughlan	Coughlan	NNP
cord-283382-t890r7xp	396	5	.	.	.
cord-283382-t890r7xp	397	1	This	this	DT
cord-283382-t890r7xp	397	2	is	be	VBZ
cord-283382-t890r7xp	397	3	an	an	DT
cord-283382-t890r7xp	397	4	open	open	JJ
cord-283382-t890r7xp	397	5	-	-	HYPH
cord-283382-t890r7xp	397	6	access	access	NN
cord-283382-t890r7xp	397	7	article	article	NN
cord-283382-t890r7xp	397	8	distributed	distribute	VBN
cord-283382-t890r7xp	397	9	under	under	IN
cord-283382-t890r7xp	397	10	the	the	DT
cord-283382-t890r7xp	397	11	terms	term	NNS
cord-283382-t890r7xp	397	12	of	of	IN
cord-283382-t890r7xp	397	13	the	the	DT
cord-283382-t890r7xp	397	14	Creative	Creative	NNP
cord-283382-t890r7xp	397	15	Commons	Commons	NNP
cord-283382-t890r7xp	397	16	Attribution	Attribution	NNP
cord-283382-t890r7xp	397	17	License	License	NNP
cord-283382-t890r7xp	397	18	(	(	-LRB-
cord-283382-t890r7xp	397	19	CC	CC	NNP
cord-283382-t890r7xp	397	20	BY	BY	NNP
cord-283382-t890r7xp	397	21	)	)	-RRB-
cord-283382-t890r7xp	397	22	.	.	.
cord-283382-t890r7xp	398	1	The	the	DT
cord-283382-t890r7xp	398	2	use	use	NN
cord-283382-t890r7xp	398	3	,	,	,
cord-283382-t890r7xp	398	4	distribution	distribution	NN
cord-283382-t890r7xp	398	5	or	or	CC
cord-283382-t890r7xp	398	6	reproduction	reproduction	NN
cord-283382-t890r7xp	398	7	in	in	IN
cord-283382-t890r7xp	398	8	other	other	JJ
cord-283382-t890r7xp	398	9	forums	forum	NNS
cord-283382-t890r7xp	398	10	is	be	VBZ
cord-283382-t890r7xp	398	11	permitted	permit	VBN
cord-283382-t890r7xp	398	12	,	,	,
cord-283382-t890r7xp	398	13	provided	provide	VBD
cord-283382-t890r7xp	398	14	the	the	DT
cord-283382-t890r7xp	398	15	original	original	JJ
cord-283382-t890r7xp	398	16	author(s	author(s	NNP
cord-283382-t890r7xp	398	17	)	)	-RRB-
cord-283382-t890r7xp	398	18	and	and	CC
cord-283382-t890r7xp	398	19	the	the	DT
cord-283382-t890r7xp	398	20	copyright	copyright	NN
cord-283382-t890r7xp	398	21	owner(s	owner(s	NNP
cord-283382-t890r7xp	398	22	)	)	-RRB-
cord-283382-t890r7xp	398	23	are	be	VBP
cord-283382-t890r7xp	398	24	credited	credit	VBN
cord-283382-t890r7xp	398	25	and	and	CC
cord-283382-t890r7xp	398	26	that	that	IN
cord-283382-t890r7xp	398	27	the	the	DT
cord-283382-t890r7xp	398	28	original	original	JJ
cord-283382-t890r7xp	398	29	publication	publication	NN
cord-283382-t890r7xp	398	30	in	in	IN
cord-283382-t890r7xp	398	31	this	this	DT
cord-283382-t890r7xp	398	32	journal	journal	NN
cord-283382-t890r7xp	398	33	is	be	VBZ
cord-283382-t890r7xp	398	34	cited	cite	VBN
cord-283382-t890r7xp	398	35	,	,	,
cord-283382-t890r7xp	398	36	in	in	IN
cord-283382-t890r7xp	398	37	accordance	accordance	NN
cord-283382-t890r7xp	398	38	with	with	IN
cord-283382-t890r7xp	398	39	accepted	accepted	JJ
cord-283382-t890r7xp	398	40	academic	academic	JJ
cord-283382-t890r7xp	398	41	practice	practice	NN
cord-283382-t890r7xp	398	42	.	.	.
cord-283382-t890r7xp	399	1	No	no	DT
cord-283382-t890r7xp	399	2	use	use	NN
cord-283382-t890r7xp	399	3	,	,	,
cord-283382-t890r7xp	399	4	distribution	distribution	NN
cord-283382-t890r7xp	399	5	or	or	CC
cord-283382-t890r7xp	399	6	reproduction	reproduction	NN
cord-283382-t890r7xp	399	7	is	be	VBZ
cord-283382-t890r7xp	399	8	permitted	permit	VBN
cord-283382-t890r7xp	399	9	which	which	WDT
cord-283382-t890r7xp	399	10	does	do	VBZ
cord-283382-t890r7xp	399	11	not	not	RB
cord-283382-t890r7xp	399	12	comply	comply	VB
cord-283382-t890r7xp	399	13	with	with	IN
cord-283382-t890r7xp	399	14	these	these	DT
cord-283382-t890r7xp	399	15	terms	term	NNS
cord-283382-t890r7xp	399	16	.	.	.