id	sid	tid	token	lemma	pos
cord-321401-w4ne60fn	1	1	key	key	NN
cord-321401-w4ne60fn	1	2	:	:	:
cord-321401-w4ne60fn	2	1	cord-321401-w4ne60fn	cord-321401-w4ne60fn	JJ
cord-321401-w4ne60fn	2	2	authors	author	NNS
cord-321401-w4ne60fn	2	3	:	:	:
cord-321401-w4ne60fn	2	4	Schrumpf	Schrumpf	NNP
cord-321401-w4ne60fn	2	5	,	,	,
cord-321401-w4ne60fn	2	6	Jasmijn	Jasmijn	NNP
cord-321401-w4ne60fn	2	7	A.	a.	NN
cord-321401-w4ne60fn	2	8	;	;	:
cord-321401-w4ne60fn	2	9	van	van	NNP
cord-321401-w4ne60fn	2	10	der	der	NNP
cord-321401-w4ne60fn	2	11	Does	Does	NNP
cord-321401-w4ne60fn	2	12	,	,	,
cord-321401-w4ne60fn	2	13	Anne	Anne	NNP
cord-321401-w4ne60fn	2	14	M.	M.	NNP
cord-321401-w4ne60fn	2	15	;	;	:
cord-321401-w4ne60fn	2	16	Hiemstra	Hiemstra	NNP
cord-321401-w4ne60fn	2	17	,	,	,
cord-321401-w4ne60fn	2	18	Pieter	Pieter	NNP
cord-321401-w4ne60fn	2	19	S.	S.	NNP
cord-321401-w4ne60fn	2	20	title	title	NN
cord-321401-w4ne60fn	2	21	:	:	:
cord-321401-w4ne60fn	2	22	Impact	impact	NN
cord-321401-w4ne60fn	2	23	of	of	IN
cord-321401-w4ne60fn	2	24	the	the	DT
cord-321401-w4ne60fn	2	25	Local	Local	NNP
cord-321401-w4ne60fn	2	26	Inflammatory	Inflammatory	NNP
cord-321401-w4ne60fn	2	27	Environment	Environment	NNP
cord-321401-w4ne60fn	2	28	on	on	IN
cord-321401-w4ne60fn	2	29	Mucosal	Mucosal	NNP
cord-321401-w4ne60fn	2	30	Vitamin	vitamin	NN
cord-321401-w4ne60fn	2	31	D	d	NN
cord-321401-w4ne60fn	2	32	Metabolism	metabolism	NN
cord-321401-w4ne60fn	2	33	and	and	CC
cord-321401-w4ne60fn	2	34	Signaling	signal	VBG
cord-321401-w4ne60fn	2	35	in	in	IN
cord-321401-w4ne60fn	2	36	Chronic	Chronic	NNP
cord-321401-w4ne60fn	2	37	Inflammatory	Inflammatory	NNP
cord-321401-w4ne60fn	2	38	Lung	Lung	NNP
cord-321401-w4ne60fn	2	39	Diseases	Diseases	NNPS
cord-321401-w4ne60fn	2	40	date	date	NN
cord-321401-w4ne60fn	2	41	:	:	:
cord-321401-w4ne60fn	2	42	2020	2020	CD
cord-321401-w4ne60fn	2	43	-	-	HYPH
cord-321401-w4ne60fn	2	44	07	07	CD
cord-321401-w4ne60fn	2	45	-	-	SYM
cord-321401-w4ne60fn	2	46	10	10	CD
cord-321401-w4ne60fn	2	47	journal	journal	NN
cord-321401-w4ne60fn	2	48	:	:	:
cord-321401-w4ne60fn	3	1	Front	Front	NNP
cord-321401-w4ne60fn	3	2	Immunol	Immunol	NNP
cord-321401-w4ne60fn	3	3	DOI	doi	NN
cord-321401-w4ne60fn	3	4	:	:	:
cord-321401-w4ne60fn	4	1	10.3389	10.3389	CD
cord-321401-w4ne60fn	5	1	/fimmu.2020.01433	/fimmu.2020.01433	,
cord-321401-w4ne60fn	5	2	sha	sha	NNP
cord-321401-w4ne60fn	5	3	:	:	:
cord-321401-w4ne60fn	5	4	ef8f4547ea7ea48e8b861a7a8aed909da4f6d53b	ef8f4547ea7ea48e8b861a7a8aed909da4f6d53b	.
cord-321401-w4ne60fn	6	1	doc_id	doc_id	CD
cord-321401-w4ne60fn	6	2	:	:	:
cord-321401-w4ne60fn	7	1	321401	321401	CD
cord-321401-w4ne60fn	7	2	cord_uid	cord_uid	NN
cord-321401-w4ne60fn	7	3	:	:	:
cord-321401-w4ne60fn	8	1	w4ne60fn	w4ne60fn	``
cord-321401-w4ne60fn	8	2	Vitamin	vitamin	NN
cord-321401-w4ne60fn	8	3	D	d	NN
cord-321401-w4ne60fn	8	4	plays	play	VBZ
cord-321401-w4ne60fn	8	5	an	an	DT
cord-321401-w4ne60fn	8	6	active	active	JJ
cord-321401-w4ne60fn	8	7	role	role	NN
cord-321401-w4ne60fn	8	8	in	in	IN
cord-321401-w4ne60fn	8	9	the	the	DT
cord-321401-w4ne60fn	8	10	modulation	modulation	NN
cord-321401-w4ne60fn	8	11	of	of	IN
cord-321401-w4ne60fn	8	12	innate	innate	JJ
cord-321401-w4ne60fn	8	13	and	and	CC
cord-321401-w4ne60fn	8	14	adaptive	adaptive	JJ
cord-321401-w4ne60fn	8	15	immune	immune	JJ
cord-321401-w4ne60fn	8	16	responses	response	NNS
cord-321401-w4ne60fn	8	17	as	as	RB
cord-321401-w4ne60fn	8	18	well	well	RB
cord-321401-w4ne60fn	8	19	as	as	IN
cord-321401-w4ne60fn	8	20	in	in	IN
cord-321401-w4ne60fn	8	21	the	the	DT
cord-321401-w4ne60fn	8	22	protection	protection	NN
cord-321401-w4ne60fn	8	23	against	against	IN
cord-321401-w4ne60fn	8	24	respiratory	respiratory	JJ
cord-321401-w4ne60fn	8	25	pathogens	pathogen	NNS
cord-321401-w4ne60fn	8	26	.	.	.
cord-321401-w4ne60fn	9	1	Evidence	evidence	NN
cord-321401-w4ne60fn	9	2	for	for	IN
cord-321401-w4ne60fn	9	3	this	this	DT
cord-321401-w4ne60fn	9	4	immunomodulatory	immunomodulatory	JJ
cord-321401-w4ne60fn	9	5	and	and	CC
cord-321401-w4ne60fn	9	6	protective	protective	JJ
cord-321401-w4ne60fn	9	7	role	role	NN
cord-321401-w4ne60fn	9	8	is	be	VBZ
cord-321401-w4ne60fn	9	9	derived	derive	VBN
cord-321401-w4ne60fn	9	10	from	from	IN
cord-321401-w4ne60fn	9	11	observational	observational	JJ
cord-321401-w4ne60fn	9	12	studies	study	NNS
cord-321401-w4ne60fn	9	13	showing	show	VBG
cord-321401-w4ne60fn	9	14	an	an	DT
cord-321401-w4ne60fn	9	15	association	association	NN
cord-321401-w4ne60fn	9	16	between	between	IN
cord-321401-w4ne60fn	9	17	vitamin	vitamin	NN
cord-321401-w4ne60fn	9	18	D	D	NNP
cord-321401-w4ne60fn	9	19	deficiency	deficiency	NN
cord-321401-w4ne60fn	9	20	,	,	,
cord-321401-w4ne60fn	9	21	chronic	chronic	JJ
cord-321401-w4ne60fn	9	22	airway	airway	NN
cord-321401-w4ne60fn	9	23	diseases	disease	NNS
cord-321401-w4ne60fn	9	24	and	and	CC
cord-321401-w4ne60fn	9	25	respiratory	respiratory	JJ
cord-321401-w4ne60fn	9	26	infections	infection	NNS
cord-321401-w4ne60fn	9	27	,	,	,
cord-321401-w4ne60fn	9	28	and	and	CC
cord-321401-w4ne60fn	9	29	is	be	VBZ
cord-321401-w4ne60fn	9	30	supported	support	VBN
cord-321401-w4ne60fn	9	31	by	by	IN
cord-321401-w4ne60fn	9	32	a	a	DT
cord-321401-w4ne60fn	9	33	range	range	NN
cord-321401-w4ne60fn	9	34	of	of	IN
cord-321401-w4ne60fn	9	35	experimental	experimental	JJ
cord-321401-w4ne60fn	9	36	studies	study	NNS
cord-321401-w4ne60fn	9	37	using	use	VBG
cord-321401-w4ne60fn	9	38	cell	cell	NN
cord-321401-w4ne60fn	9	39	culture	culture	NN
cord-321401-w4ne60fn	9	40	and	and	CC
cord-321401-w4ne60fn	9	41	animal	animal	NN
cord-321401-w4ne60fn	9	42	models	model	NNS
cord-321401-w4ne60fn	9	43	.	.	.
cord-321401-w4ne60fn	10	1	Furthermore	furthermore	RB
cord-321401-w4ne60fn	10	2	,	,	,
cord-321401-w4ne60fn	10	3	recent	recent	JJ
cord-321401-w4ne60fn	10	4	intervention	intervention	NN
cord-321401-w4ne60fn	10	5	studies	study	NNS
cord-321401-w4ne60fn	10	6	have	have	VBP
cord-321401-w4ne60fn	10	7	now	now	RB
cord-321401-w4ne60fn	10	8	shown	show	VBN
cord-321401-w4ne60fn	10	9	that	that	IN
cord-321401-w4ne60fn	10	10	vitamin	vitamin	NN
cord-321401-w4ne60fn	10	11	D	D	NNP
cord-321401-w4ne60fn	10	12	supplementation	supplementation	NN
cord-321401-w4ne60fn	10	13	reduces	reduce	VBZ
cord-321401-w4ne60fn	10	14	exacerbation	exacerbation	NN
cord-321401-w4ne60fn	10	15	rates	rate	NNS
cord-321401-w4ne60fn	10	16	in	in	IN
cord-321401-w4ne60fn	10	17	vitamin	vitamin	NN
cord-321401-w4ne60fn	10	18	D	d	NN
cord-321401-w4ne60fn	10	19	-	-	HYPH
cord-321401-w4ne60fn	10	20	deficient	deficient	JJ
cord-321401-w4ne60fn	10	21	patients	patient	NNS
cord-321401-w4ne60fn	10	22	with	with	IN
cord-321401-w4ne60fn	10	23	chronic	chronic	JJ
cord-321401-w4ne60fn	10	24	obstructive	obstructive	JJ
cord-321401-w4ne60fn	10	25	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	10	26	disease	disease	NN
cord-321401-w4ne60fn	10	27	(	(	-LRB-
cord-321401-w4ne60fn	10	28	COPD	COPD	NNP
cord-321401-w4ne60fn	10	29	)	)	-RRB-
cord-321401-w4ne60fn	10	30	or	or	CC
cord-321401-w4ne60fn	10	31	asthma	asthma	NN
cord-321401-w4ne60fn	10	32	and	and	CC
cord-321401-w4ne60fn	10	33	decreases	decrease	VBZ
cord-321401-w4ne60fn	10	34	the	the	DT
cord-321401-w4ne60fn	10	35	incidence	incidence	NN
cord-321401-w4ne60fn	10	36	of	of	IN
cord-321401-w4ne60fn	10	37	acute	acute	JJ
cord-321401-w4ne60fn	10	38	respiratory	respiratory	JJ
cord-321401-w4ne60fn	10	39	tract	tract	NN
cord-321401-w4ne60fn	10	40	infections	infection	NNS
cord-321401-w4ne60fn	10	41	.	.	.
cord-321401-w4ne60fn	11	1	The	the	DT
cord-321401-w4ne60fn	11	2	active	active	JJ
cord-321401-w4ne60fn	11	3	vitamin	vitamin	NN
cord-321401-w4ne60fn	11	4	D	d	NN
cord-321401-w4ne60fn	11	5	metabolite	metabolite	NN
cord-321401-w4ne60fn	11	6	,	,	,
cord-321401-w4ne60fn	11	7	1,25-dihydroxy	1,25-dihydroxy	CD
cord-321401-w4ne60fn	11	8	-	-	HYPH
cord-321401-w4ne60fn	11	9	vitamin	vitamin	NN
cord-321401-w4ne60fn	11	10	D	d	NN
cord-321401-w4ne60fn	11	11	(	(	-LRB-
cord-321401-w4ne60fn	11	12	1,25(OH)(2)D	1,25(oh)(2)d	CD
cord-321401-w4ne60fn	11	13	)	)	-RRB-
cord-321401-w4ne60fn	11	14	,	,	,
cord-321401-w4ne60fn	11	15	is	be	VBZ
cord-321401-w4ne60fn	11	16	known	know	VBN
cord-321401-w4ne60fn	11	17	to	to	TO
cord-321401-w4ne60fn	11	18	contribute	contribute	VB
cord-321401-w4ne60fn	11	19	to	to	IN
cord-321401-w4ne60fn	11	20	the	the	DT
cord-321401-w4ne60fn	11	21	integrity	integrity	NN
cord-321401-w4ne60fn	11	22	of	of	IN
cord-321401-w4ne60fn	11	23	the	the	DT
cord-321401-w4ne60fn	11	24	mucosal	mucosal	JJ
cord-321401-w4ne60fn	11	25	barrier	barrier	NN
cord-321401-w4ne60fn	11	26	,	,	,
cord-321401-w4ne60fn	11	27	promote	promote	VB
cord-321401-w4ne60fn	11	28	killing	killing	NN
cord-321401-w4ne60fn	11	29	of	of	IN
cord-321401-w4ne60fn	11	30	pathogens	pathogen	NNS
cord-321401-w4ne60fn	11	31	(	(	-LRB-
cord-321401-w4ne60fn	11	32	via	via	IN
cord-321401-w4ne60fn	11	33	the	the	DT
cord-321401-w4ne60fn	11	34	induction	induction	NN
cord-321401-w4ne60fn	11	35	of	of	IN
cord-321401-w4ne60fn	11	36	antimicrobial	antimicrobial	JJ
cord-321401-w4ne60fn	11	37	peptides	peptide	NNS
cord-321401-w4ne60fn	11	38	)	)	-RRB-
cord-321401-w4ne60fn	11	39	,	,	,
cord-321401-w4ne60fn	11	40	and	and	CC
cord-321401-w4ne60fn	11	41	to	to	TO
cord-321401-w4ne60fn	11	42	modulate	modulate	VB
cord-321401-w4ne60fn	11	43	inflammation	inflammation	NN
cord-321401-w4ne60fn	11	44	and	and	CC
cord-321401-w4ne60fn	11	45	immune	immune	JJ
cord-321401-w4ne60fn	11	46	responses	response	NNS
cord-321401-w4ne60fn	11	47	.	.	.
cord-321401-w4ne60fn	12	1	These	these	DT
cord-321401-w4ne60fn	12	2	mechanisms	mechanism	NNS
cord-321401-w4ne60fn	12	3	may	may	MD
cord-321401-w4ne60fn	12	4	partly	partly	RB
cord-321401-w4ne60fn	12	5	explain	explain	VB
cord-321401-w4ne60fn	12	6	its	-PRON-	PRP$
cord-321401-w4ne60fn	12	7	protective	protective	JJ
cord-321401-w4ne60fn	12	8	role	role	NN
cord-321401-w4ne60fn	12	9	against	against	IN
cord-321401-w4ne60fn	12	10	infections	infection	NNS
cord-321401-w4ne60fn	12	11	and	and	CC
cord-321401-w4ne60fn	12	12	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	12	13	in	in	IN
cord-321401-w4ne60fn	12	14	COPD	COPD	NNP
cord-321401-w4ne60fn	12	15	and	and	CC
cord-321401-w4ne60fn	12	16	asthma	asthma	NN
cord-321401-w4ne60fn	12	17	patients	patient	NNS
cord-321401-w4ne60fn	12	18	.	.	.
cord-321401-w4ne60fn	13	1	The	the	DT
cord-321401-w4ne60fn	13	2	respiratory	respiratory	JJ
cord-321401-w4ne60fn	13	3	mucosa	mucosa	NN
cord-321401-w4ne60fn	13	4	is	be	VBZ
cord-321401-w4ne60fn	13	5	an	an	DT
cord-321401-w4ne60fn	13	6	important	important	JJ
cord-321401-w4ne60fn	13	7	site	site	NN
cord-321401-w4ne60fn	13	8	of	of	IN
cord-321401-w4ne60fn	13	9	local	local	JJ
cord-321401-w4ne60fn	13	10	1,25(OH)(2)D	1,25(oh)(2)d	CD
cord-321401-w4ne60fn	13	11	synthesis	synthesis	NN
cord-321401-w4ne60fn	13	12	,	,	,
cord-321401-w4ne60fn	13	13	degradation	degradation	NN
cord-321401-w4ne60fn	13	14	and	and	CC
cord-321401-w4ne60fn	13	15	signaling	signaling	NN
cord-321401-w4ne60fn	13	16	,	,	,
cord-321401-w4ne60fn	13	17	a	a	DT
cord-321401-w4ne60fn	13	18	process	process	NN
cord-321401-w4ne60fn	13	19	that	that	WDT
cord-321401-w4ne60fn	13	20	can	can	MD
cord-321401-w4ne60fn	13	21	be	be	VB
cord-321401-w4ne60fn	13	22	affected	affect	VBN
cord-321401-w4ne60fn	13	23	by	by	IN
cord-321401-w4ne60fn	13	24	exposure	exposure	NN
cord-321401-w4ne60fn	13	25	to	to	IN
cord-321401-w4ne60fn	13	26	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	13	27	mediators	mediator	NNS
cord-321401-w4ne60fn	13	28	.	.	.
cord-321401-w4ne60fn	14	1	As	as	IN
cord-321401-w4ne60fn	14	2	a	a	DT
cord-321401-w4ne60fn	14	3	consequence	consequence	NN
cord-321401-w4ne60fn	14	4	,	,	,
cord-321401-w4ne60fn	14	5	mucosal	mucosal	JJ
cord-321401-w4ne60fn	14	6	inflammation	inflammation	NN
cord-321401-w4ne60fn	14	7	and	and	CC
cord-321401-w4ne60fn	14	8	other	other	JJ
cord-321401-w4ne60fn	14	9	disease	disease	NN
cord-321401-w4ne60fn	14	10	-	-	HYPH
cord-321401-w4ne60fn	14	11	associated	associate	VBN
cord-321401-w4ne60fn	14	12	factors	factor	NNS
cord-321401-w4ne60fn	14	13	,	,	,
cord-321401-w4ne60fn	14	14	as	as	IN
cord-321401-w4ne60fn	14	15	observed	observe	VBN
cord-321401-w4ne60fn	14	16	in	in	IN
cord-321401-w4ne60fn	14	17	e.g.	e.g.	RB
cord-321401-w4ne60fn	14	18	,	,	,
cord-321401-w4ne60fn	14	19	COPD	COPD	NNP
cord-321401-w4ne60fn	14	20	and	and	CC
cord-321401-w4ne60fn	14	21	asthma	asthma	NN
cord-321401-w4ne60fn	14	22	,	,	,
cord-321401-w4ne60fn	14	23	may	may	MD
cord-321401-w4ne60fn	14	24	modulate	modulate	VB
cord-321401-w4ne60fn	14	25	the	the	DT
cord-321401-w4ne60fn	14	26	protective	protective	JJ
cord-321401-w4ne60fn	14	27	actions	action	NNS
cord-321401-w4ne60fn	14	28	of	of	IN
cord-321401-w4ne60fn	14	29	1,25(OH)(2)D.	1,25(oh)(2)d.	CD
cord-321401-w4ne60fn	14	30	Here	here	RB
cord-321401-w4ne60fn	14	31	,	,	,
cord-321401-w4ne60fn	14	32	we	-PRON-	PRP
cord-321401-w4ne60fn	14	33	discuss	discuss	VBP
cord-321401-w4ne60fn	14	34	the	the	DT
cord-321401-w4ne60fn	14	35	potential	potential	JJ
cord-321401-w4ne60fn	14	36	consequences	consequence	NNS
cord-321401-w4ne60fn	14	37	of	of	IN
cord-321401-w4ne60fn	14	38	various	various	JJ
cord-321401-w4ne60fn	14	39	disease	disease	NN
cord-321401-w4ne60fn	14	40	-	-	HYPH
cord-321401-w4ne60fn	14	41	associated	associate	VBN
cord-321401-w4ne60fn	14	42	processes	process	NNS
cord-321401-w4ne60fn	14	43	such	such	JJ
cord-321401-w4ne60fn	14	44	as	as	IN
cord-321401-w4ne60fn	14	45	inflammation	inflammation	NN
cord-321401-w4ne60fn	14	46	and	and	CC
cord-321401-w4ne60fn	14	47	exposure	exposure	NN
cord-321401-w4ne60fn	14	48	to	to	IN
cord-321401-w4ne60fn	14	49	pathogens	pathogen	NNS
cord-321401-w4ne60fn	14	50	and	and	CC
cord-321401-w4ne60fn	14	51	inhaled	inhale	VBN
cord-321401-w4ne60fn	14	52	toxicants	toxicant	NNS
cord-321401-w4ne60fn	14	53	on	on	IN
cord-321401-w4ne60fn	14	54	vitamin	vitamin	NN
cord-321401-w4ne60fn	14	55	D	d	NN
cord-321401-w4ne60fn	14	56	metabolism	metabolism	NN
cord-321401-w4ne60fn	14	57	and	and	CC
cord-321401-w4ne60fn	14	58	local	local	JJ
cord-321401-w4ne60fn	14	59	responses	response	NNS
cord-321401-w4ne60fn	14	60	to	to	IN
cord-321401-w4ne60fn	14	61	1,25(OH)(2)D	1,25(oh)(2)d	CD
cord-321401-w4ne60fn	14	62	in	in	IN
cord-321401-w4ne60fn	14	63	both	both	CC
cord-321401-w4ne60fn	14	64	immune-	immune-	JJ
cord-321401-w4ne60fn	14	65	and	and	CC
cord-321401-w4ne60fn	14	66	epithelial	epithelial	JJ
cord-321401-w4ne60fn	14	67	cells	cell	NNS
cord-321401-w4ne60fn	14	68	.	.	.
cord-321401-w4ne60fn	15	1	We	-PRON-	PRP
cord-321401-w4ne60fn	15	2	furthermore	furthermore	RB
cord-321401-w4ne60fn	15	3	discuss	discuss	VBP
cord-321401-w4ne60fn	15	4	potential	potential	JJ
cord-321401-w4ne60fn	15	5	consequences	consequence	NNS
cord-321401-w4ne60fn	15	6	of	of	IN
cord-321401-w4ne60fn	15	7	disturbed	disturbed	JJ
cord-321401-w4ne60fn	15	8	local	local	JJ
cord-321401-w4ne60fn	15	9	levels	level	NNS
cord-321401-w4ne60fn	15	10	of	of	IN
cord-321401-w4ne60fn	15	11	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	15	12	and	and	CC
cord-321401-w4ne60fn	15	13	1,25(OH)(2)D	1,25(oh)(2)d	CD
cord-321401-w4ne60fn	15	14	for	for	IN
cord-321401-w4ne60fn	15	15	chronic	chronic	JJ
cord-321401-w4ne60fn	15	16	lung	lung	NN
cord-321401-w4ne60fn	15	17	diseases	disease	NNS
cord-321401-w4ne60fn	15	18	.	.	.
cord-321401-w4ne60fn	16	1	Additional	additional	JJ
cord-321401-w4ne60fn	16	2	insight	insight	NN
cord-321401-w4ne60fn	16	3	into	into	IN
cord-321401-w4ne60fn	16	4	the	the	DT
cord-321401-w4ne60fn	16	5	relationship	relationship	NN
cord-321401-w4ne60fn	16	6	between	between	IN
cord-321401-w4ne60fn	16	7	disease	disease	NN
cord-321401-w4ne60fn	16	8	-	-	HYPH
cord-321401-w4ne60fn	16	9	associated	associate	VBN
cord-321401-w4ne60fn	16	10	mechanisms	mechanism	NNS
cord-321401-w4ne60fn	16	11	and	and	CC
cord-321401-w4ne60fn	16	12	local	local	JJ
cord-321401-w4ne60fn	16	13	effects	effect	NNS
cord-321401-w4ne60fn	16	14	of	of	IN
cord-321401-w4ne60fn	16	15	1,25(OH)(2)D	1,25(oh)(2)d	CD
cord-321401-w4ne60fn	16	16	is	be	VBZ
cord-321401-w4ne60fn	16	17	expected	expect	VBN
cord-321401-w4ne60fn	16	18	to	to	TO
cord-321401-w4ne60fn	16	19	contribute	contribute	VB
cord-321401-w4ne60fn	16	20	to	to	IN
cord-321401-w4ne60fn	16	21	the	the	DT
cord-321401-w4ne60fn	16	22	design	design	NN
cord-321401-w4ne60fn	16	23	of	of	IN
cord-321401-w4ne60fn	16	24	future	future	JJ
cord-321401-w4ne60fn	16	25	strategies	strategy	NNS
cord-321401-w4ne60fn	16	26	aimed	aim	VBN
cord-321401-w4ne60fn	16	27	at	at	IN
cord-321401-w4ne60fn	16	28	improving	improve	VBG
cord-321401-w4ne60fn	16	29	local	local	JJ
cord-321401-w4ne60fn	16	30	levels	level	NNS
cord-321401-w4ne60fn	16	31	of	of	IN
cord-321401-w4ne60fn	16	32	1,25(OH)(2)D	1,25(oh)(2)d	CD
cord-321401-w4ne60fn	16	33	and	and	CC
cord-321401-w4ne60fn	16	34	signaling	signal	VBG
cord-321401-w4ne60fn	16	35	in	in	IN
cord-321401-w4ne60fn	16	36	chronic	chronic	JJ
cord-321401-w4ne60fn	16	37	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	16	38	lung	lung	NN
cord-321401-w4ne60fn	16	39	diseases	disease	NNS
cord-321401-w4ne60fn	16	40	.	.	.
cord-321401-w4ne60fn	17	1	Vitamin	vitamin	NN
cord-321401-w4ne60fn	17	2	D	d	NN
cord-321401-w4ne60fn	17	3	is	be	VBZ
cord-321401-w4ne60fn	17	4	a	a	DT
cord-321401-w4ne60fn	17	5	pleiotropic	pleiotropic	JJ
cord-321401-w4ne60fn	17	6	hormone	hormone	NN
cord-321401-w4ne60fn	17	7	that	that	WDT
cord-321401-w4ne60fn	17	8	is	be	VBZ
cord-321401-w4ne60fn	17	9	well	well	RB
cord-321401-w4ne60fn	17	10	-	-	HYPH
cord-321401-w4ne60fn	17	11	known	know	VBN
cord-321401-w4ne60fn	17	12	for	for	IN
cord-321401-w4ne60fn	17	13	its	-PRON-	PRP$
cord-321401-w4ne60fn	17	14	role	role	NN
cord-321401-w4ne60fn	17	15	in	in	IN
cord-321401-w4ne60fn	17	16	the	the	DT
cord-321401-w4ne60fn	17	17	regulation	regulation	NN
cord-321401-w4ne60fn	17	18	of	of	IN
cord-321401-w4ne60fn	17	19	calcium	calcium	NN
cord-321401-w4ne60fn	17	20	and	and	CC
cord-321401-w4ne60fn	17	21	phosphate	phosphate	NN
cord-321401-w4ne60fn	17	22	homeostasis	homeostasis	NN
cord-321401-w4ne60fn	17	23	and	and	CC
cord-321401-w4ne60fn	17	24	bone	bone	NN
cord-321401-w4ne60fn	17	25	mineralization	mineralization	NN
cord-321401-w4ne60fn	17	26	.	.	.
cord-321401-w4ne60fn	18	1	The	the	DT
cord-321401-w4ne60fn	18	2	vitamin	vitamin	NN
cord-321401-w4ne60fn	18	3	D	d	NN
cord-321401-w4ne60fn	18	4	receptor	receptor	NN
cord-321401-w4ne60fn	18	5	(	(	-LRB-
cord-321401-w4ne60fn	18	6	VDR	VDR	NNP
cord-321401-w4ne60fn	18	7	)	)	-RRB-
cord-321401-w4ne60fn	18	8	acts	act	VBZ
cord-321401-w4ne60fn	18	9	as	as	IN
cord-321401-w4ne60fn	18	10	the	the	DT
cord-321401-w4ne60fn	18	11	receptor	receptor	NN
cord-321401-w4ne60fn	18	12	for	for	IN
cord-321401-w4ne60fn	18	13	the	the	DT
cord-321401-w4ne60fn	18	14	active	active	JJ
cord-321401-w4ne60fn	18	15	form	form	NN
cord-321401-w4ne60fn	18	16	of	of	IN
cord-321401-w4ne60fn	18	17	vitamin	vitamin	NN
cord-321401-w4ne60fn	18	18	D	d	NN
cord-321401-w4ne60fn	18	19	,	,	,
cord-321401-w4ne60fn	18	20	i.e.	i.e.	FW
cord-321401-w4ne60fn	18	21	,	,	,
cord-321401-w4ne60fn	18	22	1,25dihydroxy	1,25dihydroxy	CD
cord-321401-w4ne60fn	18	23	-	-	HYPH
cord-321401-w4ne60fn	18	24	vitamin	vitamin	NN
cord-321401-w4ne60fn	18	25	D	d	NN
cord-321401-w4ne60fn	18	26	[	[	-LRB-
cord-321401-w4ne60fn	18	27	1	1	CD
cord-321401-w4ne60fn	18	28	,	,	,
cord-321401-w4ne60fn	18	29	25(OH	25(oh	CD
cord-321401-w4ne60fn	18	30	)	)	-RRB-
cord-321401-w4ne60fn	18	31	2	2	CD
cord-321401-w4ne60fn	18	32	D	D	NNP
cord-321401-w4ne60fn	18	33	]	]	-RRB-
cord-321401-w4ne60fn	18	34	,	,	,
cord-321401-w4ne60fn	18	35	and	and	CC
cord-321401-w4ne60fn	18	36	is	be	VBZ
cord-321401-w4ne60fn	18	37	expressed	express	VBN
cord-321401-w4ne60fn	18	38	in	in	IN
cord-321401-w4ne60fn	18	39	nearly	nearly	RB
cord-321401-w4ne60fn	18	40	all	all	DT
cord-321401-w4ne60fn	18	41	tissues	tissue	NNS
cord-321401-w4ne60fn	18	42	and	and	CC
cord-321401-w4ne60fn	18	43	cell	cell	NN
cord-321401-w4ne60fn	18	44	-	-	HYPH
cord-321401-w4ne60fn	18	45	types	type	NNS
cord-321401-w4ne60fn	18	46	and	and	CC
cord-321401-w4ne60fn	18	47	regulates	regulate	VBZ
cord-321401-w4ne60fn	18	48	a	a	DT
cord-321401-w4ne60fn	18	49	large	large	JJ
cord-321401-w4ne60fn	18	50	number	number	NN
cord-321401-w4ne60fn	18	51	of	of	IN
cord-321401-w4ne60fn	18	52	genes	gene	NNS
cord-321401-w4ne60fn	18	53	(	(	-LRB-
cord-321401-w4ne60fn	18	54	∼0.8	∼0.8	NN
cord-321401-w4ne60fn	18	55	-	-	:
cord-321401-w4ne60fn	18	56	5	5	CD
cord-321401-w4ne60fn	18	57	%	%	NN
cord-321401-w4ne60fn	18	58	of	of	IN
cord-321401-w4ne60fn	18	59	the	the	DT
cord-321401-w4ne60fn	18	60	total	total	JJ
cord-321401-w4ne60fn	18	61	genome	genome	NN
cord-321401-w4ne60fn	18	62	)	)	-RRB-
cord-321401-w4ne60fn	18	63	(	(	-LRB-
cord-321401-w4ne60fn	18	64	1	1	CD
cord-321401-w4ne60fn	18	65	,	,	,
cord-321401-w4ne60fn	18	66	2	2	CD
cord-321401-w4ne60fn	18	67	)	)	-RRB-
cord-321401-w4ne60fn	18	68	.	.	.
cord-321401-w4ne60fn	19	1	As	as	IN
cord-321401-w4ne60fn	19	2	a	a	DT
cord-321401-w4ne60fn	19	3	result	result	NN
cord-321401-w4ne60fn	19	4	,	,	,
cord-321401-w4ne60fn	19	5	vitamin	vitamin	NN
cord-321401-w4ne60fn	19	6	D	d	NN
cord-321401-w4ne60fn	19	7	affects	affect	VBZ
cord-321401-w4ne60fn	19	8	many	many	JJ
cord-321401-w4ne60fn	19	9	additional	additional	JJ
cord-321401-w4ne60fn	19	10	processes	process	NNS
cord-321401-w4ne60fn	19	11	including	include	VBG
cord-321401-w4ne60fn	19	12	cell	cell	NN
cord-321401-w4ne60fn	19	13	proliferation	proliferation	NN
cord-321401-w4ne60fn	19	14	and	and	CC
cord-321401-w4ne60fn	19	15	differentiation	differentiation	NN
cord-321401-w4ne60fn	19	16	,	,	,
cord-321401-w4ne60fn	19	17	apoptosis	apoptosis	NN
cord-321401-w4ne60fn	19	18	,	,	,
cord-321401-w4ne60fn	19	19	DNA	dna	NN
cord-321401-w4ne60fn	19	20	repair	repair	NN
cord-321401-w4ne60fn	19	21	,	,	,
cord-321401-w4ne60fn	19	22	ion	ion	NN
cord-321401-w4ne60fn	19	23	transport	transport	NN
cord-321401-w4ne60fn	19	24	,	,	,
cord-321401-w4ne60fn	19	25	metabolism	metabolism	NN
cord-321401-w4ne60fn	19	26	,	,	,
cord-321401-w4ne60fn	19	27	cell	cell	NN
cord-321401-w4ne60fn	19	28	adhesion	adhesion	NN
cord-321401-w4ne60fn	19	29	,	,	,
cord-321401-w4ne60fn	19	30	and	and	CC
cord-321401-w4ne60fn	19	31	oxidative	oxidative	JJ
cord-321401-w4ne60fn	19	32	stress	stress	NN
cord-321401-w4ne60fn	19	33	responses	response	NNS
cord-321401-w4ne60fn	19	34	(	(	-LRB-
cord-321401-w4ne60fn	19	35	1	1	CD
cord-321401-w4ne60fn	19	36	,	,	,
cord-321401-w4ne60fn	19	37	3	3	CD
cord-321401-w4ne60fn	19	38	)	)	-RRB-
cord-321401-w4ne60fn	19	39	.	.	.
cord-321401-w4ne60fn	20	1	Vitamin	vitamin	NN
cord-321401-w4ne60fn	20	2	D	d	NN
cord-321401-w4ne60fn	20	3	deficiency	deficiency	NN
cord-321401-w4ne60fn	20	4	[	[	-LRB-
cord-321401-w4ne60fn	20	5	serum	serum	NN
cord-321401-w4ne60fn	20	6	25-hydroxy	25-hydroxy	CD
cord-321401-w4ne60fn	20	7	-	-	HYPH
cord-321401-w4ne60fn	20	8	vitamin	vitamin	NN
cord-321401-w4ne60fn	20	9	D	d	NN
cord-321401-w4ne60fn	20	10	[	[	-LRB-
cord-321401-w4ne60fn	20	11	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	20	12	]	]	-RRB-
cord-321401-w4ne60fn	20	13	<	<	XX
cord-321401-w4ne60fn	20	14	50	50	CD
cord-321401-w4ne60fn	20	15	nmol	nmol	JJ
cord-321401-w4ne60fn	20	16	/	/	SYM
cord-321401-w4ne60fn	20	17	L	l	NN
cord-321401-w4ne60fn	20	18	;	;	:
cord-321401-w4ne60fn	20	19	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	20	20	is	be	VBZ
cord-321401-w4ne60fn	20	21	the	the	DT
cord-321401-w4ne60fn	20	22	main	main	JJ
cord-321401-w4ne60fn	20	23	circulating	circulate	VBG
cord-321401-w4ne60fn	20	24	form	form	NN
cord-321401-w4ne60fn	20	25	of	of	IN
cord-321401-w4ne60fn	20	26	vitamin	vitamin	NN
cord-321401-w4ne60fn	20	27	D	d	NN
cord-321401-w4ne60fn	20	28	and	and	CC
cord-321401-w4ne60fn	20	29	its	-PRON-	PRP$
cord-321401-w4ne60fn	20	30	levels	level	NNS
cord-321401-w4ne60fn	20	31	are	be	VBP
cord-321401-w4ne60fn	20	32	used	use	VBN
cord-321401-w4ne60fn	20	33	to	to	TO
cord-321401-w4ne60fn	20	34	assess	assess	VB
cord-321401-w4ne60fn	20	35	vitamin	vitamin	NN
cord-321401-w4ne60fn	20	36	D	d	NN
cord-321401-w4ne60fn	20	37	status	status	NN
cord-321401-w4ne60fn	20	38	in	in	IN
cord-321401-w4ne60fn	20	39	the	the	DT
cord-321401-w4ne60fn	20	40	clinic	clinic	NN
cord-321401-w4ne60fn	20	41	(	(	-LRB-
cord-321401-w4ne60fn	20	42	4	4	CD
cord-321401-w4ne60fn	20	43	,	,	,
cord-321401-w4ne60fn	20	44	5	5	CD
cord-321401-w4ne60fn	20	45	)	)	-RRB-
cord-321401-w4ne60fn	20	46	affects	affect	VBZ
cord-321401-w4ne60fn	20	47	more	more	JJR
cord-321401-w4ne60fn	20	48	than	than	IN
cord-321401-w4ne60fn	20	49	30	30	CD
cord-321401-w4ne60fn	20	50	%	%	NN
cord-321401-w4ne60fn	20	51	of	of	IN
cord-321401-w4ne60fn	20	52	the	the	DT
cord-321401-w4ne60fn	20	53	children	child	NNS
cord-321401-w4ne60fn	20	54	and	and	CC
cord-321401-w4ne60fn	20	55	adults	adult	NNS
cord-321401-w4ne60fn	20	56	worldwide	worldwide	RB
cord-321401-w4ne60fn	20	57	and	and	CC
cord-321401-w4ne60fn	20	58	is	be	VBZ
cord-321401-w4ne60fn	20	59	a	a	DT
cord-321401-w4ne60fn	20	60	major	major	JJ
cord-321401-w4ne60fn	20	61	cause	cause	NN
cord-321401-w4ne60fn	20	62	of	of	IN
cord-321401-w4ne60fn	20	63	bone	bone	NN
cord-321401-w4ne60fn	20	64	diseases	disease	NNS
cord-321401-w4ne60fn	20	65	such	such	JJ
cord-321401-w4ne60fn	20	66	as	as	IN
cord-321401-w4ne60fn	20	67	rickets	ricket	NNS
cord-321401-w4ne60fn	20	68	and	and	CC
cord-321401-w4ne60fn	20	69	osteoporosis	osteoporosis	NN
cord-321401-w4ne60fn	20	70	(	(	-LRB-
cord-321401-w4ne60fn	20	71	6	6	CD
cord-321401-w4ne60fn	20	72	)	)	-RRB-
cord-321401-w4ne60fn	20	73	.	.	.
cord-321401-w4ne60fn	21	1	Increasing	increase	VBG
cord-321401-w4ne60fn	21	2	evidence	evidence	NN
cord-321401-w4ne60fn	21	3	has	have	VBZ
cord-321401-w4ne60fn	21	4	indicated	indicate	VBN
cord-321401-w4ne60fn	21	5	that	that	IN
cord-321401-w4ne60fn	21	6	vitamin	vitamin	NN
cord-321401-w4ne60fn	21	7	D	d	NN
cord-321401-w4ne60fn	21	8	deficiency	deficiency	NN
cord-321401-w4ne60fn	21	9	is	be	VBZ
cord-321401-w4ne60fn	21	10	also	also	RB
cord-321401-w4ne60fn	21	11	associated	associate	VBN
cord-321401-w4ne60fn	21	12	with	with	IN
cord-321401-w4ne60fn	21	13	various	various	JJ
cord-321401-w4ne60fn	21	14	other	other	JJ
cord-321401-w4ne60fn	21	15	diseases	disease	NNS
cord-321401-w4ne60fn	21	16	such	such	JJ
cord-321401-w4ne60fn	21	17	as	as	IN
cord-321401-w4ne60fn	21	18	cancer	cancer	NN
cord-321401-w4ne60fn	21	19	,	,	,
cord-321401-w4ne60fn	21	20	cardiovascular	cardiovascular	JJ
cord-321401-w4ne60fn	21	21	disease	disease	NN
cord-321401-w4ne60fn	21	22	,	,	,
cord-321401-w4ne60fn	21	23	Alzheimer	Alzheimer	NNP
cord-321401-w4ne60fn	21	24	's	's	POS
cord-321401-w4ne60fn	21	25	disease	disease	NN
cord-321401-w4ne60fn	21	26	and	and	CC
cord-321401-w4ne60fn	21	27	muscle	muscle	NN
cord-321401-w4ne60fn	21	28	myopathy	myopathy	NN
cord-321401-w4ne60fn	21	29	,	,	,
cord-321401-w4ne60fn	21	30	as	as	RB
cord-321401-w4ne60fn	21	31	well	well	RB
cord-321401-w4ne60fn	21	32	as	as	IN
cord-321401-w4ne60fn	21	33	several	several	JJ
cord-321401-w4ne60fn	21	34	immune	immune	NN
cord-321401-w4ne60fn	21	35	-	-	HYPH
cord-321401-w4ne60fn	21	36	related	relate	VBN
cord-321401-w4ne60fn	21	37	diseases	disease	NNS
cord-321401-w4ne60fn	21	38	such	such	JJ
cord-321401-w4ne60fn	21	39	as	as	IN
cord-321401-w4ne60fn	21	40	type	type	NN
cord-321401-w4ne60fn	21	41	1	1	CD
cord-321401-w4ne60fn	21	42	diabetes	diabetes	NN
cord-321401-w4ne60fn	21	43	,	,	,
cord-321401-w4ne60fn	21	44	multiple	multiple	JJ
cord-321401-w4ne60fn	21	45	sclerosis	sclerosis	NN
cord-321401-w4ne60fn	21	46	,	,	,
cord-321401-w4ne60fn	21	47	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	21	48	bowel	bowel	NN
cord-321401-w4ne60fn	21	49	disease	disease	NN
cord-321401-w4ne60fn	21	50	(	(	-LRB-
cord-321401-w4ne60fn	21	51	IBD	IBD	NNP
cord-321401-w4ne60fn	21	52	)	)	-RRB-
cord-321401-w4ne60fn	21	53	,	,	,
cord-321401-w4ne60fn	21	54	psoriasis	psoriasis	NN
cord-321401-w4ne60fn	21	55	and	and	CC
cord-321401-w4ne60fn	21	56	chronic	chronic	JJ
cord-321401-w4ne60fn	21	57	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	21	58	lung	lung	NN
cord-321401-w4ne60fn	21	59	diseases	disease	NNS
cord-321401-w4ne60fn	21	60	including	include	VBG
cord-321401-w4ne60fn	21	61	asthma	asthma	NN
cord-321401-w4ne60fn	21	62	,	,	,
cord-321401-w4ne60fn	21	63	cystic	cystic	JJ
cord-321401-w4ne60fn	21	64	fibrosis	fibrosis	NN
cord-321401-w4ne60fn	21	65	(	(	-LRB-
cord-321401-w4ne60fn	21	66	CF	CF	NNP
cord-321401-w4ne60fn	21	67	)	)	-RRB-
cord-321401-w4ne60fn	21	68	,	,	,
cord-321401-w4ne60fn	21	69	and	and	CC
cord-321401-w4ne60fn	21	70	chronic	chronic	JJ
cord-321401-w4ne60fn	21	71	obstructive	obstructive	JJ
cord-321401-w4ne60fn	21	72	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	21	73	disease	disease	NN
cord-321401-w4ne60fn	21	74	(	(	-LRB-
cord-321401-w4ne60fn	21	75	COPD	COPD	NNP
cord-321401-w4ne60fn	21	76	)	)	-RRB-
cord-321401-w4ne60fn	21	77	(	(	-LRB-
cord-321401-w4ne60fn	21	78	6	6	LS
cord-321401-w4ne60fn	21	79	)	)	-RRB-
cord-321401-w4ne60fn	21	80	(	(	-LRB-
cord-321401-w4ne60fn	21	81	7	7	LS
cord-321401-w4ne60fn	21	82	)	)	-RRB-
cord-321401-w4ne60fn	21	83	(	(	-LRB-
cord-321401-w4ne60fn	21	84	8)	8)	NNP
cord-321401-w4ne60fn	21	85	(	(	-LRB-
cord-321401-w4ne60fn	21	86	9	9	CD
cord-321401-w4ne60fn	21	87	)	)	-RRB-
cord-321401-w4ne60fn	21	88	.	.	.
cord-321401-w4ne60fn	22	1	Several	several	JJ
cord-321401-w4ne60fn	22	2	studies	study	NNS
cord-321401-w4ne60fn	22	3	have	have	VBP
cord-321401-w4ne60fn	22	4	now	now	RB
cord-321401-w4ne60fn	22	5	shown	show	VBN
cord-321401-w4ne60fn	22	6	that	that	IN
cord-321401-w4ne60fn	22	7	vitamin	vitamin	NN
cord-321401-w4ne60fn	22	8	D	d	NN
cord-321401-w4ne60fn	22	9	deficiency	deficiency	NN
cord-321401-w4ne60fn	22	10	is	be	VBZ
cord-321401-w4ne60fn	22	11	prevalent	prevalent	JJ
cord-321401-w4ne60fn	22	12	in	in	IN
cord-321401-w4ne60fn	22	13	COPD	COPD	NNP
cord-321401-w4ne60fn	22	14	patients	patient	NNS
cord-321401-w4ne60fn	22	15	and	and	CC
cord-321401-w4ne60fn	22	16	inversely	inversely	RB
cord-321401-w4ne60fn	22	17	correlated	correlate	VBD
cord-321401-w4ne60fn	22	18	with	with	IN
cord-321401-w4ne60fn	22	19	lung	lung	NN
cord-321401-w4ne60fn	22	20	function	function	NN
cord-321401-w4ne60fn	22	21	and	and	CC
cord-321401-w4ne60fn	22	22	severity	severity	NN
cord-321401-w4ne60fn	22	23	of	of	IN
cord-321401-w4ne60fn	22	24	the	the	DT
cord-321401-w4ne60fn	22	25	disease	disease	NN
cord-321401-w4ne60fn	22	26	(	(	-LRB-
cord-321401-w4ne60fn	22	27	8)	8)	NNP
cord-321401-w4ne60fn	22	28	(	(	-LRB-
cord-321401-w4ne60fn	22	29	9	9	CD
cord-321401-w4ne60fn	22	30	)	)	-RRB-
cord-321401-w4ne60fn	22	31	(	(	-LRB-
cord-321401-w4ne60fn	22	32	10	10	CD
cord-321401-w4ne60fn	22	33	)	)	-RRB-
cord-321401-w4ne60fn	22	34	(	(	-LRB-
cord-321401-w4ne60fn	22	35	11	11	CD
cord-321401-w4ne60fn	22	36	)	)	-RRB-
cord-321401-w4ne60fn	22	37	(	(	-LRB-
cord-321401-w4ne60fn	22	38	12	12	CD
cord-321401-w4ne60fn	22	39	)	)	-RRB-
cord-321401-w4ne60fn	22	40	.	.	.
cord-321401-w4ne60fn	23	1	It	-PRON-	PRP
cord-321401-w4ne60fn	23	2	is	be	VBZ
cord-321401-w4ne60fn	23	3	currently	currently	RB
cord-321401-w4ne60fn	23	4	unknown	unknown	JJ
cord-321401-w4ne60fn	23	5	whether	whether	IN
cord-321401-w4ne60fn	23	6	vitamin	vitamin	NN
cord-321401-w4ne60fn	23	7	D	d	NN
cord-321401-w4ne60fn	23	8	deficiency	deficiency	NN
cord-321401-w4ne60fn	23	9	is	be	VBZ
cord-321401-w4ne60fn	23	10	a	a	DT
cord-321401-w4ne60fn	23	11	cause	cause	NN
cord-321401-w4ne60fn	23	12	or	or	CC
cord-321401-w4ne60fn	23	13	consequence	consequence	NN
cord-321401-w4ne60fn	23	14	of	of	IN
cord-321401-w4ne60fn	23	15	COPD	COPD	NNP
cord-321401-w4ne60fn	23	16	,	,	,
cord-321401-w4ne60fn	23	17	since	since	IN
cord-321401-w4ne60fn	23	18	many	many	JJ
cord-321401-w4ne60fn	23	19	COPD	COPD	NNP
cord-321401-w4ne60fn	23	20	patients	patient	NNS
cord-321401-w4ne60fn	23	21	have	have	VBP
cord-321401-w4ne60fn	23	22	low	low	JJ
cord-321401-w4ne60fn	23	23	physical	physical	JJ
cord-321401-w4ne60fn	23	24	activity	activity	NN
cord-321401-w4ne60fn	23	25	levels	level	NNS
cord-321401-w4ne60fn	23	26	and	and	CC
cord-321401-w4ne60fn	23	27	spend	spend	VB
cord-321401-w4ne60fn	23	28	most	most	JJS
cord-321401-w4ne60fn	23	29	time	time	NN
cord-321401-w4ne60fn	23	30	indoors	indoors	RB
cord-321401-w4ne60fn	23	31	(	(	-LRB-
cord-321401-w4ne60fn	23	32	13	13	CD
cord-321401-w4ne60fn	23	33	)	)	-RRB-
cord-321401-w4ne60fn	23	34	.	.	.
cord-321401-w4ne60fn	24	1	There	there	EX
cord-321401-w4ne60fn	24	2	are	be	VBP
cord-321401-w4ne60fn	24	3	however	however	RB
cord-321401-w4ne60fn	24	4	studies	study	NNS
cord-321401-w4ne60fn	24	5	suggesting	suggest	VBG
cord-321401-w4ne60fn	24	6	that	that	IN
cord-321401-w4ne60fn	24	7	low	low	JJ
cord-321401-w4ne60fn	24	8	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	24	9	levels	level	NNS
cord-321401-w4ne60fn	24	10	are	be	VBP
cord-321401-w4ne60fn	24	11	associated	associate	VBN
cord-321401-w4ne60fn	24	12	with	with	IN
cord-321401-w4ne60fn	24	13	development	development	NN
cord-321401-w4ne60fn	24	14	of	of	IN
cord-321401-w4ne60fn	24	15	COPD	COPD	NNP
cord-321401-w4ne60fn	24	16	,	,	,
cord-321401-w4ne60fn	24	17	based	base	VBN
cord-321401-w4ne60fn	24	18	on	on	IN
cord-321401-w4ne60fn	24	19	observed	observed	JJ
cord-321401-w4ne60fn	24	20	associations	association	NNS
cord-321401-w4ne60fn	24	21	between	between	IN
cord-321401-w4ne60fn	24	22	polymorphisms	polymorphism	NNS
cord-321401-w4ne60fn	24	23	in	in	IN
cord-321401-w4ne60fn	24	24	the	the	DT
cord-321401-w4ne60fn	24	25	vitamin	vitamin	NN
cord-321401-w4ne60fn	24	26	D	d	NN
cord-321401-w4ne60fn	24	27	binding	bind	VBG
cord-321401-w4ne60fn	24	28	protein	protein	NN
cord-321401-w4ne60fn	24	29	(	(	-LRB-
cord-321401-w4ne60fn	24	30	VDBP	VDBP	NNP
cord-321401-w4ne60fn	24	31	)	)	-RRB-
cord-321401-w4ne60fn	24	32	,	,	,
cord-321401-w4ne60fn	24	33	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	24	34	serum	serum	NN
cord-321401-w4ne60fn	24	35	levels	level	NNS
cord-321401-w4ne60fn	24	36	and	and	CC
cord-321401-w4ne60fn	24	37	COPD	COPD	NNP
cord-321401-w4ne60fn	24	38	severity	severity	NN
cord-321401-w4ne60fn	24	39	(	(	-LRB-
cord-321401-w4ne60fn	24	40	8	8	CD
cord-321401-w4ne60fn	24	41	,	,	,
cord-321401-w4ne60fn	24	42	10	10	CD
cord-321401-w4ne60fn	24	43	,	,	,
cord-321401-w4ne60fn	24	44	11	11	CD
cord-321401-w4ne60fn	24	45	,	,	,
cord-321401-w4ne60fn	24	46	14	14	CD
cord-321401-w4ne60fn	24	47	)	)	-RRB-
cord-321401-w4ne60fn	24	48	.	.	.
cord-321401-w4ne60fn	25	1	In	in	IN
cord-321401-w4ne60fn	25	2	addition	addition	NN
cord-321401-w4ne60fn	25	3	,	,	,
cord-321401-w4ne60fn	25	4	one	one	CD
cord-321401-w4ne60fn	25	5	study	study	NN
cord-321401-w4ne60fn	25	6	in	in	IN
cord-321401-w4ne60fn	25	7	mice	mouse	NNS
cord-321401-w4ne60fn	25	8	showed	show	VBD
cord-321401-w4ne60fn	25	9	that	that	IN
cord-321401-w4ne60fn	25	10	maternal	maternal	JJ
cord-321401-w4ne60fn	25	11	vitamin	vitamin	NN
cord-321401-w4ne60fn	25	12	D	D	NNP
cord-321401-w4ne60fn	25	13	deficiency	deficiency	NN
cord-321401-w4ne60fn	25	14	can	can	MD
cord-321401-w4ne60fn	25	15	impair	impair	VB
cord-321401-w4ne60fn	25	16	lung	lung	NN
cord-321401-w4ne60fn	25	17	-development	-development	NN
cord-321401-w4ne60fn	25	18	,	,	,
cord-321401-w4ne60fn	26	1	-structure	-structure	JJ
cord-321401-w4ne60fn	26	2	andfunction	andfunction	NN
cord-321401-w4ne60fn	26	3	in	in	IN
cord-321401-w4ne60fn	26	4	the	the	DT
cord-321401-w4ne60fn	26	5	offspring	offspring	NN
cord-321401-w4ne60fn	26	6	and	and	CC
cord-321401-w4ne60fn	26	7	suggests	suggest	VBZ
cord-321401-w4ne60fn	26	8	that	that	IN
cord-321401-w4ne60fn	26	9	even	even	RB
cord-321401-w4ne60fn	26	10	before	before	IN
cord-321401-w4ne60fn	26	11	birth	birth	NN
cord-321401-w4ne60fn	26	12	,	,	,
cord-321401-w4ne60fn	26	13	maternal	maternal	JJ
cord-321401-w4ne60fn	26	14	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	26	15	serum	serum	NN
cord-321401-w4ne60fn	26	16	levels	level	NNS
cord-321401-w4ne60fn	26	17	are	be	VBP
cord-321401-w4ne60fn	26	18	important	important	JJ
cord-321401-w4ne60fn	26	19	for	for	IN
cord-321401-w4ne60fn	26	20	a	a	DT
cord-321401-w4ne60fn	26	21	healthy	healthy	JJ
cord-321401-w4ne60fn	26	22	lung	lung	NN
cord-321401-w4ne60fn	26	23	development	development	NN
cord-321401-w4ne60fn	26	24	(	(	-LRB-
cord-321401-w4ne60fn	26	25	15	15	CD
cord-321401-w4ne60fn	26	26	)	)	-RRB-
cord-321401-w4ne60fn	26	27	.	.	.
cord-321401-w4ne60fn	27	1	This	this	DT
cord-321401-w4ne60fn	27	2	might	may	MD
cord-321401-w4ne60fn	27	3	be	be	VB
cord-321401-w4ne60fn	27	4	relevant	relevant	JJ
cord-321401-w4ne60fn	27	5	,	,	,
cord-321401-w4ne60fn	27	6	since	since	IN
cord-321401-w4ne60fn	27	7	associations	association	NNS
cord-321401-w4ne60fn	27	8	have	have	VBP
cord-321401-w4ne60fn	27	9	been	be	VBN
cord-321401-w4ne60fn	27	10	found	find	VBN
cord-321401-w4ne60fn	27	11	between	between	IN
cord-321401-w4ne60fn	27	12	lower	low	JJR
cord-321401-w4ne60fn	27	13	childhood	childhood	NN
cord-321401-w4ne60fn	27	14	lung	lung	NN
cord-321401-w4ne60fn	27	15	function	function	NN
cord-321401-w4ne60fn	27	16	and	and	CC
cord-321401-w4ne60fn	27	17	development	development	NN
cord-321401-w4ne60fn	27	18	of	of	IN
cord-321401-w4ne60fn	27	19	COPD	COPD	NNP
cord-321401-w4ne60fn	27	20	later	later	RB
cord-321401-w4ne60fn	27	21	in	in	IN
cord-321401-w4ne60fn	27	22	life	life	NN
cord-321401-w4ne60fn	27	23	(	(	-LRB-
cord-321401-w4ne60fn	27	24	16	16	CD
cord-321401-w4ne60fn	27	25	)	)	-RRB-
cord-321401-w4ne60fn	27	26	.	.	.
cord-321401-w4ne60fn	28	1	The	the	DT
cord-321401-w4ne60fn	28	2	link	link	NN
cord-321401-w4ne60fn	28	3	between	between	IN
cord-321401-w4ne60fn	28	4	maternal	maternal	JJ
cord-321401-w4ne60fn	28	5	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	28	6	status	status	NN
cord-321401-w4ne60fn	28	7	and	and	CC
cord-321401-w4ne60fn	28	8	asthma	asthma	NN
cord-321401-w4ne60fn	28	9	development	development	NN
cord-321401-w4ne60fn	28	10	is	be	VBZ
cord-321401-w4ne60fn	28	11	however	however	RB
cord-321401-w4ne60fn	28	12	much	much	RB
cord-321401-w4ne60fn	28	13	clearer	clear	JJR
cord-321401-w4ne60fn	28	14	,	,	,
cord-321401-w4ne60fn	28	15	since	since	IN
cord-321401-w4ne60fn	28	16	two	two	CD
cord-321401-w4ne60fn	28	17	recent	recent	JJ
cord-321401-w4ne60fn	28	18	randomized	randomize	VBN
cord-321401-w4ne60fn	28	19	controlled	control	VBN
cord-321401-w4ne60fn	28	20	trials	trial	NNS
cord-321401-w4ne60fn	28	21	(	(	-LRB-
cord-321401-w4ne60fn	28	22	RCTs	RCTs	NNP
cord-321401-w4ne60fn	28	23	)	)	-RRB-
cord-321401-w4ne60fn	28	24	have	have	VBP
cord-321401-w4ne60fn	28	25	shown	show	VBN
cord-321401-w4ne60fn	28	26	that	that	IN
cord-321401-w4ne60fn	28	27	maternal	maternal	JJ
cord-321401-w4ne60fn	28	28	vitamin	vitamin	NN
cord-321401-w4ne60fn	28	29	D	D	NNP
cord-321401-w4ne60fn	28	30	supplementation	supplementation	NN
cord-321401-w4ne60fn	28	31	reduces	reduce	VBZ
cord-321401-w4ne60fn	28	32	the	the	DT
cord-321401-w4ne60fn	28	33	risk	risk	NN
cord-321401-w4ne60fn	28	34	of	of	IN
cord-321401-w4ne60fn	28	35	childhood	childhood	NN
cord-321401-w4ne60fn	28	36	asthma	asthma	NN
cord-321401-w4ne60fn	28	37	/	/	SYM
cord-321401-w4ne60fn	28	38	recurrent	recurrent	JJ
cord-321401-w4ne60fn	28	39	wheeze	wheeze	NN
cord-321401-w4ne60fn	28	40	(	(	-LRB-
cord-321401-w4ne60fn	28	41	17	17	CD
cord-321401-w4ne60fn	28	42	)	)	-RRB-
cord-321401-w4ne60fn	28	43	.	.	.
cord-321401-w4ne60fn	29	1	This	this	DT
cord-321401-w4ne60fn	29	2	might	may	MD
cord-321401-w4ne60fn	29	3	be	be	VB
cord-321401-w4ne60fn	29	4	explained	explain	VBN
cord-321401-w4ne60fn	29	5	by	by	IN
cord-321401-w4ne60fn	29	6	the	the	DT
cord-321401-w4ne60fn	29	7	fact	fact	NN
cord-321401-w4ne60fn	29	8	that	that	IN
cord-321401-w4ne60fn	29	9	multiple	multiple	JJ
cord-321401-w4ne60fn	29	10	vitamin	vitamin	NN
cord-321401-w4ne60fn	29	11	D	d	NN
cord-321401-w4ne60fn	29	12	-	-	HYPH
cord-321401-w4ne60fn	29	13	regulated	regulate	VBN
cord-321401-w4ne60fn	29	14	genes	gene	NNS
cord-321401-w4ne60fn	29	15	are	be	VBP
cord-321401-w4ne60fn	29	16	transcriptionally	transcriptionally	RB
cord-321401-w4ne60fn	29	17	active	active	JJ
cord-321401-w4ne60fn	29	18	during	during	IN
cord-321401-w4ne60fn	29	19	alveolar	alveolar	JJ
cord-321401-w4ne60fn	29	20	maturation	maturation	NN
cord-321401-w4ne60fn	29	21	and	and	CC
cord-321401-w4ne60fn	29	22	a	a	DT
cord-321401-w4ne60fn	29	23	number	number	NN
cord-321401-w4ne60fn	29	24	of	of	IN
cord-321401-w4ne60fn	29	25	these	these	DT
cord-321401-w4ne60fn	29	26	genes	gene	NNS
cord-321401-w4ne60fn	29	27	are	be	VBP
cord-321401-w4ne60fn	29	28	differentially	differentially	RB
cord-321401-w4ne60fn	29	29	expressed	express	VBN
cord-321401-w4ne60fn	29	30	in	in	IN
cord-321401-w4ne60fn	29	31	asthma	asthma	NN
cord-321401-w4ne60fn	29	32	(	(	-LRB-
cord-321401-w4ne60fn	29	33	18	18	CD
cord-321401-w4ne60fn	29	34	)	)	-RRB-
cord-321401-w4ne60fn	29	35	.	.	.
cord-321401-w4ne60fn	30	1	Additionally	additionally	RB
cord-321401-w4ne60fn	30	2	,	,	,
cord-321401-w4ne60fn	30	3	this	this	DT
cord-321401-w4ne60fn	30	4	protective	protective	JJ
cord-321401-w4ne60fn	30	5	effect	effect	NN
cord-321401-w4ne60fn	30	6	was	be	VBD
cord-321401-w4ne60fn	30	7	linked	link	VBN
cord-321401-w4ne60fn	30	8	to	to	IN
cord-321401-w4ne60fn	30	9	the	the	DT
cord-321401-w4ne60fn	30	10	GGgenotype	GGgenotype	NNP
cord-321401-w4ne60fn	30	11	of	of	IN
cord-321401-w4ne60fn	30	12	the	the	DT
cord-321401-w4ne60fn	30	13	17q21	17q21	CD
cord-321401-w4ne60fn	30	14	functional	functional	JJ
cord-321401-w4ne60fn	30	15	SNP	SNP	NNP
cord-321401-w4ne60fn	30	16	rs12936231	rs12936231	NN
cord-321401-w4ne60fn	30	17	,	,	,
cord-321401-w4ne60fn	30	18	which	which	WDT
cord-321401-w4ne60fn	30	19	is	be	VBZ
cord-321401-w4ne60fn	30	20	associated	associate	VBN
cord-321401-w4ne60fn	30	21	with	with	IN
cord-321401-w4ne60fn	30	22	lower	low	JJR
cord-321401-w4ne60fn	30	23	expression	expression	NN
cord-321401-w4ne60fn	30	24	of	of	IN
cord-321401-w4ne60fn	30	25	ORMDL3	ormdl3	NN
cord-321401-w4ne60fn	30	26	and	and	CC
cord-321401-w4ne60fn	30	27	increased	increase	VBN
cord-321401-w4ne60fn	30	28	sphingolipid	sphingolipid	NN
cord-321401-w4ne60fn	30	29	metabolism	metabolism	NN
cord-321401-w4ne60fn	30	30	(	(	-LRB-
cord-321401-w4ne60fn	30	31	19	19	CD
cord-321401-w4ne60fn	30	32	)	)	-RRB-
cord-321401-w4ne60fn	30	33	.	.	.
cord-321401-w4ne60fn	31	1	Moreover	moreover	RB
cord-321401-w4ne60fn	31	2	,	,	,
cord-321401-w4ne60fn	31	3	maternal	maternal	JJ
cord-321401-w4ne60fn	31	4	circulating	circulate	VBG
cord-321401-w4ne60fn	31	5	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	31	6	levels	level	NNS
cord-321401-w4ne60fn	31	7	affect	affect	VBP
cord-321401-w4ne60fn	31	8	the	the	DT
cord-321401-w4ne60fn	31	9	gut	gut	NN
cord-321401-w4ne60fn	31	10	microbiota	microbiota	NN
cord-321401-w4ne60fn	31	11	and	and	CC
cord-321401-w4ne60fn	31	12	can	can	MD
cord-321401-w4ne60fn	31	13	therefore	therefore	RB
cord-321401-w4ne60fn	31	14	indirectly	indirectly	RB
cord-321401-w4ne60fn	31	15	modulate	modulate	VB
cord-321401-w4ne60fn	31	16	immune	immune	JJ
cord-321401-w4ne60fn	31	17	responses	response	NNS
cord-321401-w4ne60fn	31	18	in	in	IN
cord-321401-w4ne60fn	31	19	the	the	DT
cord-321401-w4ne60fn	31	20	lung	lung	NN
cord-321401-w4ne60fn	31	21	via	via	IN
cord-321401-w4ne60fn	31	22	the	the	DT
cord-321401-w4ne60fn	31	23	gutlung	gutlung	NNP
cord-321401-w4ne60fn	31	24	-	-	HYPH
cord-321401-w4ne60fn	31	25	axis	axis	NN
cord-321401-w4ne60fn	31	26	(	(	-LRB-
cord-321401-w4ne60fn	31	27	20	20	CD
cord-321401-w4ne60fn	31	28	)	)	-RRB-
cord-321401-w4ne60fn	31	29	.	.	.
cord-321401-w4ne60fn	32	1	Also	also	RB
cord-321401-w4ne60fn	32	2	later	later	RB
cord-321401-w4ne60fn	32	3	in	in	IN
cord-321401-w4ne60fn	32	4	life	life	NN
cord-321401-w4ne60fn	32	5	,	,	,
cord-321401-w4ne60fn	32	6	optimal	optimal	JJ
cord-321401-w4ne60fn	32	7	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	32	8	levels	level	NNS
cord-321401-w4ne60fn	32	9	remain	remain	VBP
cord-321401-w4ne60fn	32	10	crucial	crucial	JJ
cord-321401-w4ne60fn	32	11	for	for	IN
cord-321401-w4ne60fn	32	12	keeping	keep	VBG
cord-321401-w4ne60fn	32	13	the	the	DT
cord-321401-w4ne60fn	32	14	lungs	lung	NNS
cord-321401-w4ne60fn	32	15	healthy	healthy	JJ
cord-321401-w4ne60fn	32	16	.	.	.
cord-321401-w4ne60fn	33	1	For	for	IN
cord-321401-w4ne60fn	33	2	example	example	NN
cord-321401-w4ne60fn	33	3	,	,	,
cord-321401-w4ne60fn	33	4	Heulens	Heulens	NNP
cord-321401-w4ne60fn	33	5	et	et	NNP
cord-321401-w4ne60fn	33	6	al	al	NNP
cord-321401-w4ne60fn	33	7	.	.	NNP
cord-321401-w4ne60fn	33	8	showed	show	VBD
cord-321401-w4ne60fn	33	9	that	that	IN
cord-321401-w4ne60fn	33	10	subacute	subacute	JJ
cord-321401-w4ne60fn	33	11	and	and	CC
cord-321401-w4ne60fn	33	12	chronic	chronic	JJ
cord-321401-w4ne60fn	33	13	cigarette	cigarette	NN
cord-321401-w4ne60fn	33	14	smoke	smoke	NN
cord-321401-w4ne60fn	33	15	(	(	-LRB-
cord-321401-w4ne60fn	33	16	CS	CS	NNP
cord-321401-w4ne60fn	33	17	)	)	-RRB-
cord-321401-w4ne60fn	33	18	exposure	exposure	NN
cord-321401-w4ne60fn	33	19	decreased	decrease	VBD
cord-321401-w4ne60fn	33	20	lung	lung	NN
cord-321401-w4ne60fn	33	21	function	function	NN
cord-321401-w4ne60fn	33	22	and	and	CC
cord-321401-w4ne60fn	33	23	promoted	promote	VBD
cord-321401-w4ne60fn	33	24	early	early	JJ
cord-321401-w4ne60fn	33	25	signs	sign	NNS
cord-321401-w4ne60fn	33	26	of	of	IN
cord-321401-w4ne60fn	33	27	emphysema	emphysema	NN
cord-321401-w4ne60fn	33	28	and	and	CC
cord-321401-w4ne60fn	33	29	airway	airway	NN
cord-321401-w4ne60fn	33	30	inflammation	inflammation	NN
cord-321401-w4ne60fn	33	31	in	in	IN
cord-321401-w4ne60fn	33	32	vitamin	vitamin	NN
cord-321401-w4ne60fn	33	33	D	d	NN
cord-321401-w4ne60fn	33	34	-	-	HYPH
cord-321401-w4ne60fn	33	35	deficient	deficient	JJ
cord-321401-w4ne60fn	33	36	mice	mouse	NNS
cord-321401-w4ne60fn	33	37	compared	compare	VBN
cord-321401-w4ne60fn	33	38	to	to	IN
cord-321401-w4ne60fn	33	39	vitamin	vitamin	NN
cord-321401-w4ne60fn	33	40	D	d	NN
cord-321401-w4ne60fn	33	41	-	-	HYPH
cord-321401-w4ne60fn	33	42	sufficient	sufficient	JJ
cord-321401-w4ne60fn	33	43	animals	animal	NNS
cord-321401-w4ne60fn	33	44	(	(	-LRB-
cord-321401-w4ne60fn	33	45	21	21	CD
cord-321401-w4ne60fn	33	46	)	)	-RRB-
cord-321401-w4ne60fn	33	47	.	.	.
cord-321401-w4ne60fn	34	1	Similarly	similarly	RB
cord-321401-w4ne60fn	34	2	in	in	IN
cord-321401-w4ne60fn	34	3	an	an	DT
cord-321401-w4ne60fn	34	4	elastase	elastase	NN
cord-321401-w4ne60fn	34	5	-	-	HYPH
cord-321401-w4ne60fn	34	6	induced	induce	VBN
cord-321401-w4ne60fn	34	7	COPD	COPD	NNP
cord-321401-w4ne60fn	34	8	mouse	mouse	NN
cord-321401-w4ne60fn	34	9	model	model	NN
cord-321401-w4ne60fn	34	10	,	,	,
cord-321401-w4ne60fn	34	11	topical	topical	JJ
cord-321401-w4ne60fn	34	12	administration	administration	NN
cord-321401-w4ne60fn	34	13	of	of	IN
cord-321401-w4ne60fn	34	14	vitamin	vitamin	NN
cord-321401-w4ne60fn	34	15	D	D	NNP
cord-321401-w4ne60fn	34	16	in	in	IN
cord-321401-w4ne60fn	34	17	the	the	DT
cord-321401-w4ne60fn	34	18	lungs	lung	NNS
cord-321401-w4ne60fn	34	19	counteracted	counteract	VBD
cord-321401-w4ne60fn	34	20	alveolar	alveolar	JJ
cord-321401-w4ne60fn	34	21	damage	damage	NN
cord-321401-w4ne60fn	34	22	and	and	CC
cord-321401-w4ne60fn	34	23	improved	improved	JJ
cord-321401-w4ne60fn	34	24	lung	lung	NN
cord-321401-w4ne60fn	34	25	function	function	NN
cord-321401-w4ne60fn	34	26	(	(	-LRB-
cord-321401-w4ne60fn	34	27	22	22	CD
cord-321401-w4ne60fn	34	28	)	)	-RRB-
cord-321401-w4ne60fn	34	29	.	.	.
cord-321401-w4ne60fn	35	1	Yet	yet	CC
cord-321401-w4ne60fn	35	2	in	in	IN
cord-321401-w4ne60fn	35	3	humans	human	NNS
cord-321401-w4ne60fn	35	4	,	,	,
cord-321401-w4ne60fn	35	5	it	-PRON-	PRP
cord-321401-w4ne60fn	35	6	is	be	VBZ
cord-321401-w4ne60fn	35	7	still	still	RB
cord-321401-w4ne60fn	35	8	unclear	unclear	JJ
cord-321401-w4ne60fn	35	9	whether	whether	IN
cord-321401-w4ne60fn	35	10	vitamin	vitamin	NN
cord-321401-w4ne60fn	35	11	D	d	NN
cord-321401-w4ne60fn	35	12	status	status	NN
cord-321401-w4ne60fn	35	13	influences	influence	VBZ
cord-321401-w4ne60fn	35	14	COPD	COPD	NNP
cord-321401-w4ne60fn	35	15	development	development	NN
cord-321401-w4ne60fn	35	16	and	and	CC
cord-321401-w4ne60fn	35	17	disease	disease	NN
cord-321401-w4ne60fn	35	18	progression	progression	NN
cord-321401-w4ne60fn	35	19	.	.	.
cord-321401-w4ne60fn	36	1	Taken	take	VBN
cord-321401-w4ne60fn	36	2	together	together	RB
cord-321401-w4ne60fn	36	3	,	,	,
cord-321401-w4ne60fn	36	4	these	these	DT
cord-321401-w4ne60fn	36	5	observations	observation	NNS
cord-321401-w4ne60fn	36	6	suggest	suggest	VBP
cord-321401-w4ne60fn	36	7	an	an	DT
cord-321401-w4ne60fn	36	8	important	important	JJ
cord-321401-w4ne60fn	36	9	role	role	NN
cord-321401-w4ne60fn	36	10	for	for	IN
cord-321401-w4ne60fn	36	11	vitamin	vitamin	NN
cord-321401-w4ne60fn	36	12	D	d	NN
cord-321401-w4ne60fn	36	13	during	during	IN
cord-321401-w4ne60fn	36	14	fetal	fetal	JJ
cord-321401-w4ne60fn	36	15	and	and	CC
cord-321401-w4ne60fn	36	16	childhood	childhood	NN
cord-321401-w4ne60fn	36	17	lung	lung	NN
cord-321401-w4ne60fn	36	18	maturation	maturation	NN
cord-321401-w4ne60fn	36	19	,	,	,
cord-321401-w4ne60fn	36	20	and	and	CC
cord-321401-w4ne60fn	36	21	indicate	indicate	VBP
cord-321401-w4ne60fn	36	22	that	that	IN
cord-321401-w4ne60fn	36	23	sufficient	sufficient	JJ
cord-321401-w4ne60fn	36	24	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	36	25	levels	level	NNS
cord-321401-w4ne60fn	36	26	might	may	MD
cord-321401-w4ne60fn	36	27	contribute	contribute	VB
cord-321401-w4ne60fn	36	28	to	to	IN
cord-321401-w4ne60fn	36	29	protection	protection	NN
cord-321401-w4ne60fn	36	30	against	against	IN
cord-321401-w4ne60fn	36	31	development	development	NN
cord-321401-w4ne60fn	36	32	of	of	IN
cord-321401-w4ne60fn	36	33	childhood	childhood	NN
cord-321401-w4ne60fn	36	34	asthma	asthma	NN
cord-321401-w4ne60fn	36	35	and	and	CC
cord-321401-w4ne60fn	36	36	possibly	possibly	RB
cord-321401-w4ne60fn	36	37	COPD	COPD	NNP
cord-321401-w4ne60fn	36	38	at	at	IN
cord-321401-w4ne60fn	36	39	older	old	JJR
cord-321401-w4ne60fn	36	40	age	age	NN
cord-321401-w4ne60fn	36	41	.	.	.
cord-321401-w4ne60fn	37	1	Systemic	systemic	JJ
cord-321401-w4ne60fn	37	2	levels	level	NNS
cord-321401-w4ne60fn	37	3	of	of	IN
cord-321401-w4ne60fn	37	4	biologically	biologically	RB
cord-321401-w4ne60fn	37	5	active	active	JJ
cord-321401-w4ne60fn	37	6	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	37	7	)	)	-RRB-
cord-321401-w4ne60fn	38	1	2	2	LS
cord-321401-w4ne60fn	38	2	D	d	NN
cord-321401-w4ne60fn	38	3	are	be	VBP
cord-321401-w4ne60fn	38	4	tightly	tightly	RB
cord-321401-w4ne60fn	38	5	regulated	regulate	VBN
cord-321401-w4ne60fn	38	6	to	to	TO
cord-321401-w4ne60fn	38	7	preserve	preserve	VB
cord-321401-w4ne60fn	38	8	sufficient	sufficient	JJ
cord-321401-w4ne60fn	38	9	levels	level	NNS
cord-321401-w4ne60fn	38	10	of	of	IN
cord-321401-w4ne60fn	38	11	calcium	calcium	NN
cord-321401-w4ne60fn	39	1	(	(	-LRB-
cord-321401-w4ne60fn	39	2	Ca	Ca	NNP
cord-321401-w4ne60fn	39	3	2	2	CD
cord-321401-w4ne60fn	39	4	+	+	SYM
cord-321401-w4ne60fn	39	5	)	)	-RRB-
cord-321401-w4ne60fn	39	6	and	and	CC
cord-321401-w4ne60fn	39	7	phosphate	phosphate	NN
cord-321401-w4ne60fn	39	8	(	(	-LRB-
cord-321401-w4ne60fn	39	9	PO	PO	NNP
cord-321401-w4ne60fn	39	10	4	4	CD
cord-321401-w4ne60fn	39	11	2−	2−	CD
cord-321401-w4ne60fn	39	12	)	)	-RRB-
cord-321401-w4ne60fn	39	13	for	for	IN
cord-321401-w4ne60fn	39	14	optimal	optimal	JJ
cord-321401-w4ne60fn	39	15	bone	bone	NN
cord-321401-w4ne60fn	39	16	mineralization	mineralization	NN
cord-321401-w4ne60fn	39	17	,	,	,
cord-321401-w4ne60fn	39	18	whereas	whereas	IN
cord-321401-w4ne60fn	39	19	in	in	IN
cord-321401-w4ne60fn	39	20	mucosal	mucosal	JJ
cord-321401-w4ne60fn	39	21	tissues	tissue	NNS
cord-321401-w4ne60fn	39	22	locally	locally	RB
cord-321401-w4ne60fn	39	23	produced	produce	VBN
cord-321401-w4ne60fn	39	24	(	(	-LRB-
cord-321401-w4ne60fn	39	25	autocrine	autocrine	NN
cord-321401-w4ne60fn	39	26	)	)	-RRB-
cord-321401-w4ne60fn	39	27	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	39	28	)	)	-RRB-
cord-321401-w4ne60fn	39	29	2	2	CD
cord-321401-w4ne60fn	39	30	D	d	NN
cord-321401-w4ne60fn	39	31	levels	level	NNS
cord-321401-w4ne60fn	39	32	and	and	CC
cord-321401-w4ne60fn	39	33	signaling	signaling	NN
cord-321401-w4ne60fn	39	34	can	can	MD
cord-321401-w4ne60fn	39	35	be	be	VB
cord-321401-w4ne60fn	39	36	elevated	elevate	VBN
cord-321401-w4ne60fn	39	37	or	or	CC
cord-321401-w4ne60fn	39	38	decreased	decrease	VBN
cord-321401-w4ne60fn	39	39	upon	upon	IN
cord-321401-w4ne60fn	39	40	exposure	exposure	NN
cord-321401-w4ne60fn	39	41	to	to	IN
cord-321401-w4ne60fn	39	42	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	39	43	mediators	mediator	NNS
cord-321401-w4ne60fn	39	44	,	,	,
cord-321401-w4ne60fn	39	45	pathogens	pathogen	NNS
cord-321401-w4ne60fn	39	46	or	or	CC
cord-321401-w4ne60fn	39	47	inhaled	inhale	VBN
cord-321401-w4ne60fn	39	48	toxicants	toxicant	NNS
cord-321401-w4ne60fn	39	49	(	(	-LRB-
cord-321401-w4ne60fn	39	50	6	6	CD
cord-321401-w4ne60fn	39	51	)	)	-RRB-
cord-321401-w4ne60fn	39	52	.	.	.
cord-321401-w4ne60fn	40	1	This	this	DT
cord-321401-w4ne60fn	40	2	could	could	MD
cord-321401-w4ne60fn	40	3	be	be	VB
cord-321401-w4ne60fn	40	4	important	important	JJ
cord-321401-w4ne60fn	40	5	,	,	,
cord-321401-w4ne60fn	40	6	since	since	IN
cord-321401-w4ne60fn	40	7	the	the	DT
cord-321401-w4ne60fn	40	8	inflamed	inflamed	JJ
cord-321401-w4ne60fn	40	9	airway	airway	NN
cord-321401-w4ne60fn	40	10	mucosa	mucosa	NN
cord-321401-w4ne60fn	40	11	of	of	IN
cord-321401-w4ne60fn	40	12	patients	patient	NNS
cord-321401-w4ne60fn	40	13	suffering	suffer	VBG
cord-321401-w4ne60fn	40	14	from	from	IN
cord-321401-w4ne60fn	40	15	chronic	chronic	JJ
cord-321401-w4ne60fn	40	16	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	40	17	lung	lung	NN
cord-321401-w4ne60fn	40	18	diseases	disease	NNS
cord-321401-w4ne60fn	40	19	is	be	VBZ
cord-321401-w4ne60fn	40	20	constantly	constantly	RB
cord-321401-w4ne60fn	40	21	exposed	expose	VBN
cord-321401-w4ne60fn	40	22	to	to	IN
cord-321401-w4ne60fn	40	23	these	these	DT
cord-321401-w4ne60fn	40	24	disease	disease	NN
cord-321401-w4ne60fn	40	25	-	-	HYPH
cord-321401-w4ne60fn	40	26	associated	associate	VBN
cord-321401-w4ne60fn	40	27	factors	factor	NNS
cord-321401-w4ne60fn	40	28	(	(	-LRB-
cord-321401-w4ne60fn	40	29	8	8	CD
cord-321401-w4ne60fn	40	30	,	,	,
cord-321401-w4ne60fn	40	31	23	23	CD
cord-321401-w4ne60fn	40	32	,	,	,
cord-321401-w4ne60fn	40	33	24	24	CD
cord-321401-w4ne60fn	40	34	)	)	-RRB-
cord-321401-w4ne60fn	40	35	.	.	.
cord-321401-w4ne60fn	41	1	Impaired	impaired	JJ
cord-321401-w4ne60fn	41	2	local	local	JJ
cord-321401-w4ne60fn	41	3	levels	level	NNS
cord-321401-w4ne60fn	41	4	of	of	IN
cord-321401-w4ne60fn	41	5	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	41	6	)	)	-RRB-
cord-321401-w4ne60fn	41	7	2	2	CD
cord-321401-w4ne60fn	41	8	D	d	NN
cord-321401-w4ne60fn	41	9	and	and	CC
cord-321401-w4ne60fn	41	10	VDR	VDR	NNP
cord-321401-w4ne60fn	41	11	signaling	signal	VBG
cord-321401-w4ne60fn	41	12	might	may	MD
cord-321401-w4ne60fn	41	13	have	have	VB
cord-321401-w4ne60fn	41	14	consequences	consequence	NNS
cord-321401-w4ne60fn	41	15	for	for	IN
cord-321401-w4ne60fn	41	16	disease	disease	NN
cord-321401-w4ne60fn	41	17	pathogenesis	pathogenesis	NN
cord-321401-w4ne60fn	41	18	and	and	CC
cord-321401-w4ne60fn	41	19	progression	progression	NN
cord-321401-w4ne60fn	41	20	.	.	.
cord-321401-w4ne60fn	42	1	Dysregulated	dysregulated	JJ
cord-321401-w4ne60fn	42	2	host	host	NN
cord-321401-w4ne60fn	42	3	defenses	defense	NNS
cord-321401-w4ne60fn	42	4	as	as	IN
cord-321401-w4ne60fn	42	5	found	find	VBN
cord-321401-w4ne60fn	42	6	in	in	IN
cord-321401-w4ne60fn	42	7	patients	patient	NNS
cord-321401-w4ne60fn	42	8	with	with	IN
cord-321401-w4ne60fn	42	9	chronic	chronic	JJ
cord-321401-w4ne60fn	42	10	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	42	11	airway	airway	NN
cord-321401-w4ne60fn	42	12	diseases	disease	NNS
cord-321401-w4ne60fn	42	13	include	include	VBP
cord-321401-w4ne60fn	42	14	aberrant	aberrant	JJ
cord-321401-w4ne60fn	42	15	immune	immune	JJ
cord-321401-w4ne60fn	42	16	responses	response	NNS
cord-321401-w4ne60fn	42	17	,	,	,
cord-321401-w4ne60fn	42	18	altered	alter	VBN
cord-321401-w4ne60fn	42	19	microbiome	microbiome	NN
cord-321401-w4ne60fn	42	20	composition	composition	NN
cord-321401-w4ne60fn	42	21	,	,	,
cord-321401-w4ne60fn	42	22	impaired	impair	VBN
cord-321401-w4ne60fn	42	23	epithelial	epithelial	JJ
cord-321401-w4ne60fn	42	24	barrier	barrier	NN
cord-321401-w4ne60fn	42	25	function	function	NN
cord-321401-w4ne60fn	42	26	,	,	,
cord-321401-w4ne60fn	42	27	and	and	CC
cord-321401-w4ne60fn	42	28	aberrant	aberrant	JJ
cord-321401-w4ne60fn	42	29	secretion	secretion	NN
cord-321401-w4ne60fn	42	30	of	of	IN
cord-321401-w4ne60fn	42	31	host	host	NN
cord-321401-w4ne60fn	42	32	defense	defense	NN
cord-321401-w4ne60fn	42	33	molecules	molecule	NNS
cord-321401-w4ne60fn	42	34	(	(	-LRB-
cord-321401-w4ne60fn	42	35	25	25	CD
cord-321401-w4ne60fn	42	36	)	)	-RRB-
cord-321401-w4ne60fn	42	37	(	(	-LRB-
cord-321401-w4ne60fn	42	38	26	26	CD
cord-321401-w4ne60fn	42	39	)	)	-RRB-
cord-321401-w4ne60fn	42	40	(	(	-LRB-
cord-321401-w4ne60fn	42	41	27	27	CD
cord-321401-w4ne60fn	42	42	)	)	-RRB-
cord-321401-w4ne60fn	42	43	.	.	.
cord-321401-w4ne60fn	43	1	Adequate	adequate	JJ
cord-321401-w4ne60fn	43	2	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	43	3	)	)	-RRB-
cord-321401-w4ne60fn	43	4	2	2	CD
cord-321401-w4ne60fn	43	5	D	d	NN
cord-321401-w4ne60fn	43	6	levels	level	NNS
cord-321401-w4ne60fn	43	7	may	may	MD
cord-321401-w4ne60fn	43	8	provide	provide	VB
cord-321401-w4ne60fn	43	9	protection	protection	NN
cord-321401-w4ne60fn	43	10	against	against	IN
cord-321401-w4ne60fn	43	11	these	these	DT
cord-321401-w4ne60fn	43	12	dysregulated	dysregulate	VBN
cord-321401-w4ne60fn	43	13	processes	process	NNS
cord-321401-w4ne60fn	43	14	by	by	IN
cord-321401-w4ne60fn	43	15	maintaining	maintain	VBG
cord-321401-w4ne60fn	43	16	the	the	DT
cord-321401-w4ne60fn	43	17	integrity	integrity	NN
cord-321401-w4ne60fn	43	18	of	of	IN
cord-321401-w4ne60fn	43	19	the	the	DT
cord-321401-w4ne60fn	43	20	mucosal	mucosal	JJ
cord-321401-w4ne60fn	43	21	barrier	barrier	NN
cord-321401-w4ne60fn	43	22	and	and	CC
cord-321401-w4ne60fn	43	23	promotion	promotion	NN
cord-321401-w4ne60fn	43	24	of	of	IN
cord-321401-w4ne60fn	43	25	killing	killing	NN
cord-321401-w4ne60fn	43	26	of	of	IN
cord-321401-w4ne60fn	43	27	pathogens	pathogen	NNS
cord-321401-w4ne60fn	43	28	(	(	-LRB-
cord-321401-w4ne60fn	43	29	e.g.	e.g.	RB
cord-321401-w4ne60fn	43	30	,	,	,
cord-321401-w4ne60fn	43	31	via	via	IN
cord-321401-w4ne60fn	43	32	the	the	DT
cord-321401-w4ne60fn	43	33	induction	induction	NN
cord-321401-w4ne60fn	43	34	of	of	IN
cord-321401-w4ne60fn	43	35	the	the	DT
cord-321401-w4ne60fn	43	36	antimicrobial	antimicrobial	JJ
cord-321401-w4ne60fn	43	37	peptide	peptide	NN
cord-321401-w4ne60fn	43	38	[	[	-LRB-
cord-321401-w4ne60fn	43	39	AMP	AMP	NNP
cord-321401-w4ne60fn	43	40	]	]	-RRB-
cord-321401-w4ne60fn	44	1	hCAP18	hCAP18	NNP
cord-321401-w4ne60fn	44	2	/	/	SYM
cord-321401-w4ne60fn	44	3	LL-37	LL-37	NNP
cord-321401-w4ne60fn	44	4	)	)	-RRB-
cord-321401-w4ne60fn	45	1	and	and	CC
cord-321401-w4ne60fn	45	2	via	via	IN
cord-321401-w4ne60fn	45	3	the	the	DT
cord-321401-w4ne60fn	45	4	modulation	modulation	NN
cord-321401-w4ne60fn	45	5	of	of	IN
cord-321401-w4ne60fn	45	6	both	both	DT
cord-321401-w4ne60fn	45	7	innate	innate	JJ
cord-321401-w4ne60fn	45	8	and	and	CC
cord-321401-w4ne60fn	45	9	adaptive	adaptive	JJ
cord-321401-w4ne60fn	45	10	immune	immune	JJ
cord-321401-w4ne60fn	45	11	responses	response	NNS
cord-321401-w4ne60fn	45	12	(	(	-LRB-
cord-321401-w4ne60fn	45	13	7	7	CD
cord-321401-w4ne60fn	45	14	,	,	,
cord-321401-w4ne60fn	45	15	28	28	CD
cord-321401-w4ne60fn	45	16	,	,	,
cord-321401-w4ne60fn	45	17	29	29	CD
cord-321401-w4ne60fn	45	18	)	)	-RRB-
cord-321401-w4ne60fn	45	19	.	.	.
cord-321401-w4ne60fn	46	1	In	in	IN
cord-321401-w4ne60fn	46	2	this	this	DT
cord-321401-w4ne60fn	46	3	review	review	NN
cord-321401-w4ne60fn	46	4	,	,	,
cord-321401-w4ne60fn	46	5	we	-PRON-	PRP
cord-321401-w4ne60fn	46	6	first	first	RB
cord-321401-w4ne60fn	46	7	discuss	discuss	VBP
cord-321401-w4ne60fn	46	8	the	the	DT
cord-321401-w4ne60fn	46	9	effects	effect	NNS
cord-321401-w4ne60fn	46	10	of	of	IN
cord-321401-w4ne60fn	46	11	these	these	DT
cord-321401-w4ne60fn	46	12	disease	disease	NN
cord-321401-w4ne60fn	46	13	-	-	HYPH
cord-321401-w4ne60fn	46	14	associated	associate	VBN
cord-321401-w4ne60fn	46	15	factors	factor	NNS
cord-321401-w4ne60fn	46	16	on	on	IN
cord-321401-w4ne60fn	46	17	local	local	JJ
cord-321401-w4ne60fn	46	18	synthesis	synthesis	NN
cord-321401-w4ne60fn	46	19	and	and	CC
cord-321401-w4ne60fn	46	20	availability	availability	NN
cord-321401-w4ne60fn	46	21	of	of	IN
cord-321401-w4ne60fn	46	22	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	46	23	)	)	-RRB-
cord-321401-w4ne60fn	46	24	2	2	CD
cord-321401-w4ne60fn	46	25	D	d	NN
cord-321401-w4ne60fn	46	26	and	and	CC
cord-321401-w4ne60fn	46	27	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	46	28	)	)	-RRB-
cord-321401-w4ne60fn	46	29	2	2	CD
cord-321401-w4ne60fn	46	30	D	d	NN
cord-321401-w4ne60fn	46	31	-	-	HYPH
cord-321401-w4ne60fn	46	32	induced	induce	VBN
cord-321401-w4ne60fn	46	33	responses	response	NNS
cord-321401-w4ne60fn	46	34	in	in	IN
cord-321401-w4ne60fn	46	35	the	the	DT
cord-321401-w4ne60fn	46	36	lung	lung	NN
cord-321401-w4ne60fn	46	37	mucosa	mucosa	RB
cord-321401-w4ne60fn	46	38	.	.	.
cord-321401-w4ne60fn	47	1	In	in	IN
cord-321401-w4ne60fn	47	2	the	the	DT
cord-321401-w4ne60fn	47	3	second	second	JJ
cord-321401-w4ne60fn	47	4	part	part	NN
cord-321401-w4ne60fn	47	5	of	of	IN
cord-321401-w4ne60fn	47	6	the	the	DT
cord-321401-w4ne60fn	47	7	review	review	NN
cord-321401-w4ne60fn	47	8	we	-PRON-	PRP
cord-321401-w4ne60fn	47	9	will	will	MD
cord-321401-w4ne60fn	47	10	describe	describe	VB
cord-321401-w4ne60fn	47	11	the	the	DT
cord-321401-w4ne60fn	47	12	mechanistic	mechanistic	JJ
cord-321401-w4ne60fn	47	13	links	link	NNS
cord-321401-w4ne60fn	47	14	between	between	IN
cord-321401-w4ne60fn	47	15	vitamin	vitamin	NN
cord-321401-w4ne60fn	47	16	D	d	NN
cord-321401-w4ne60fn	47	17	deficiency	deficiency	NN
cord-321401-w4ne60fn	47	18	and	and	CC
cord-321401-w4ne60fn	47	19	the	the	DT
cord-321401-w4ne60fn	47	20	pathogenesis	pathogenesis	NN
cord-321401-w4ne60fn	47	21	of	of	IN
cord-321401-w4ne60fn	47	22	chronic	chronic	JJ
cord-321401-w4ne60fn	47	23	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	47	24	lung	lung	NN
cord-321401-w4ne60fn	47	25	diseases	disease	NNS
cord-321401-w4ne60fn	47	26	such	such	JJ
cord-321401-w4ne60fn	47	27	as	as	IN
cord-321401-w4ne60fn	47	28	asthma	asthma	NN
cord-321401-w4ne60fn	47	29	,	,	,
cord-321401-w4ne60fn	47	30	CF	CF	NNP
cord-321401-w4ne60fn	47	31	and	and	CC
cord-321401-w4ne60fn	47	32	COPD	COPD	NNP
cord-321401-w4ne60fn	47	33	,	,	,
cord-321401-w4ne60fn	47	34	and	and	CC
cord-321401-w4ne60fn	47	35	discuss	discuss	VB
cord-321401-w4ne60fn	47	36	recent	recent	JJ
cord-321401-w4ne60fn	47	37	evidence	evidence	NN
cord-321401-w4ne60fn	47	38	related	relate	VBN
cord-321401-w4ne60fn	47	39	to	to	IN
cord-321401-w4ne60fn	47	40	the	the	DT
cord-321401-w4ne60fn	47	41	protective	protective	JJ
cord-321401-w4ne60fn	47	42	effects	effect	NNS
cord-321401-w4ne60fn	47	43	of	of	IN
cord-321401-w4ne60fn	47	44	vitamin	vitamin	NN
cord-321401-w4ne60fn	47	45	D	d	NN
cord-321401-w4ne60fn	47	46	on	on	IN
cord-321401-w4ne60fn	47	47	COPD	COPD	NNP
cord-321401-w4ne60fn	47	48	and	and	CC
cord-321401-w4ne60fn	47	49	on	on	IN
cord-321401-w4ne60fn	47	50	COPD	COPD	NNP
cord-321401-w4ne60fn	47	51	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	47	52	.	.	.
cord-321401-w4ne60fn	48	1	Vitamin	vitamin	NN
cord-321401-w4ne60fn	48	2	D	d	NN
cord-321401-w4ne60fn	48	3	enters	enter	VBZ
cord-321401-w4ne60fn	48	4	the	the	DT
cord-321401-w4ne60fn	48	5	circulation	circulation	NN
cord-321401-w4ne60fn	48	6	either	either	CC
cord-321401-w4ne60fn	48	7	via	via	IN
cord-321401-w4ne60fn	48	8	food	food	NN
cord-321401-w4ne60fn	48	9	intake	intake	NN
cord-321401-w4ne60fn	48	10	(	(	-LRB-
cord-321401-w4ne60fn	48	11	plantbased	plantbased	JJ
cord-321401-w4ne60fn	48	12	:	:	:
cord-321401-w4ne60fn	48	13	vitamin	vitamin	NN
cord-321401-w4ne60fn	48	14	D	D	NNP
cord-321401-w4ne60fn	48	15	2	2	CD
cord-321401-w4ne60fn	48	16	/animal	/animal	.
cord-321401-w4ne60fn	49	1	-based	-based	JJ
cord-321401-w4ne60fn	49	2	:	:	:
cord-321401-w4ne60fn	49	3	vitamin	vitamin	NN
cord-321401-w4ne60fn	49	4	D	D	NNP
cord-321401-w4ne60fn	49	5	3	3	CD
cord-321401-w4ne60fn	49	6	)	)	-RRB-
cord-321401-w4ne60fn	49	7	or	or	CC
cord-321401-w4ne60fn	49	8	as	as	IN
cord-321401-w4ne60fn	49	9	a	a	DT
cord-321401-w4ne60fn	49	10	result	result	NN
cord-321401-w4ne60fn	49	11	of	of	IN
cord-321401-w4ne60fn	49	12	its	-PRON-	PRP$
cord-321401-w4ne60fn	49	13	synthesis	synthesis	NN
cord-321401-w4ne60fn	49	14	in	in	IN
cord-321401-w4ne60fn	49	15	the	the	DT
cord-321401-w4ne60fn	49	16	skin	skin	NN
cord-321401-w4ne60fn	49	17	by	by	IN
cord-321401-w4ne60fn	49	18	UVB	uvb	NN
cord-321401-w4ne60fn	49	19	radiation	radiation	NN
cord-321401-w4ne60fn	49	20	.	.	.
cord-321401-w4ne60fn	50	1	It	-PRON-	PRP
cord-321401-w4ne60fn	50	2	subsequently	subsequently	RB
cord-321401-w4ne60fn	50	3	binds	bind	VBZ
cord-321401-w4ne60fn	50	4	to	to	IN
cord-321401-w4ne60fn	50	5	the	the	DT
cord-321401-w4ne60fn	50	6	VDBP	VDBP	NNP
cord-321401-w4ne60fn	50	7	(	(	-LRB-
cord-321401-w4ne60fn	50	8	30	30	CD
cord-321401-w4ne60fn	50	9	,	,	,
cord-321401-w4ne60fn	50	10	31	31	CD
cord-321401-w4ne60fn	50	11	)	)	-RRB-
cord-321401-w4ne60fn	50	12	,	,	,
cord-321401-w4ne60fn	50	13	after	after	IN
cord-321401-w4ne60fn	50	14	which	which	WDT
cord-321401-w4ne60fn	50	15	this	this	DT
cord-321401-w4ne60fn	50	16	complex	complex	NN
cord-321401-w4ne60fn	50	17	is	be	VBZ
cord-321401-w4ne60fn	50	18	transported	transport	VBN
cord-321401-w4ne60fn	50	19	to	to	IN
cord-321401-w4ne60fn	50	20	the	the	DT
cord-321401-w4ne60fn	50	21	liver	liver	NN
cord-321401-w4ne60fn	50	22	where	where	WRB
cord-321401-w4ne60fn	50	23	it	-PRON-	PRP
cord-321401-w4ne60fn	50	24	is	be	VBZ
cord-321401-w4ne60fn	50	25	converted	convert	VBN
cord-321401-w4ne60fn	50	26	by	by	IN
cord-321401-w4ne60fn	50	27	vitamin	vitamin	NN
cord-321401-w4ne60fn	50	28	D-25hydroxylases	D-25hydroxylases	NNP
cord-321401-w4ne60fn	50	29	(	(	-LRB-
cord-321401-w4ne60fn	50	30	CYP2RI	CYP2RI	NNP
cord-321401-w4ne60fn	50	31	and	and	CC
cord-321401-w4ne60fn	50	32	CYP27A1	CYP27A1	NNP
cord-321401-w4ne60fn	50	33	)	)	-RRB-
cord-321401-w4ne60fn	50	34	into	into	IN
cord-321401-w4ne60fn	50	35	25(OH)D.	25(oh)d.	CD
cord-321401-w4ne60fn	51	1	However	however	RB
cord-321401-w4ne60fn	51	2	,	,	,
cord-321401-w4ne60fn	51	3	recent	recent	JJ
cord-321401-w4ne60fn	51	4	studies	study	NNS
cord-321401-w4ne60fn	51	5	showed	show	VBD
cord-321401-w4ne60fn	51	6	that	that	IN
cord-321401-w4ne60fn	51	7	also	also	RB
cord-321401-w4ne60fn	51	8	other	other	JJ
cord-321401-w4ne60fn	51	9	cell	cell	NN
cord-321401-w4ne60fn	51	10	types	type	NNS
cord-321401-w4ne60fn	51	11	such	such	JJ
cord-321401-w4ne60fn	51	12	as	as	IN
cord-321401-w4ne60fn	51	13	airway	airway	NN
cord-321401-w4ne60fn	51	14	epithelial	epithelial	JJ
cord-321401-w4ne60fn	51	15	cells	cell	NNS
cord-321401-w4ne60fn	51	16	,	,	,
cord-321401-w4ne60fn	51	17	keratinocytes	keratinocyte	NNS
cord-321401-w4ne60fn	51	18	,	,	,
cord-321401-w4ne60fn	51	19	intestinal	intestinal	JJ
cord-321401-w4ne60fn	51	20	epithelial	epithelial	JJ
cord-321401-w4ne60fn	51	21	cells	cell	NNS
cord-321401-w4ne60fn	51	22	,	,	,
cord-321401-w4ne60fn	51	23	and	and	CC
cord-321401-w4ne60fn	51	24	monocytes	monocyte	NNS
cord-321401-w4ne60fn	51	25	/	/	SYM
cord-321401-w4ne60fn	51	26	macrophages	macrophage	NNS
cord-321401-w4ne60fn	51	27	express	express	VBP
cord-321401-w4ne60fn	51	28	CYP2RI	CYP2RI	NNP
cord-321401-w4ne60fn	51	29	and	and	CC
cord-321401-w4ne60fn	51	30	CYP27A1	CYP27A1	NNP
cord-321401-w4ne60fn	51	31	,	,	,
cord-321401-w4ne60fn	51	32	and	and	CC
cord-321401-w4ne60fn	51	33	thus	thus	RB
cord-321401-w4ne60fn	51	34	are	be	VBP
cord-321401-w4ne60fn	51	35	able	able	JJ
cord-321401-w4ne60fn	51	36	to	to	TO
cord-321401-w4ne60fn	51	37	(	(	-LRB-
cord-321401-w4ne60fn	51	38	locally	locally	RB
cord-321401-w4ne60fn	51	39	)	)	-RRB-
cord-321401-w4ne60fn	51	40	convert	convert	VB
cord-321401-w4ne60fn	51	41	vitamin	vitamin	NN
cord-321401-w4ne60fn	51	42	D	d	NN
cord-321401-w4ne60fn	51	43	3	3	CD
cord-321401-w4ne60fn	51	44	into	into	IN
cord-321401-w4ne60fn	51	45	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	51	46	3	3	CD
cord-321401-w4ne60fn	51	47	(	(	-LRB-
cord-321401-w4ne60fn	51	48	32	32	CD
cord-321401-w4ne60fn	51	49	,	,	,
cord-321401-w4ne60fn	51	50	33	33	CD
cord-321401-w4ne60fn	51	51	)	)	-RRB-
cord-321401-w4ne60fn	51	52	.	.	.
cord-321401-w4ne60fn	52	1	This	this	DT
cord-321401-w4ne60fn	52	2	inactive	inactive	JJ
cord-321401-w4ne60fn	52	3	25(OH)D	25(oh)d	NN
cord-321401-w4ne60fn	52	4	needs	need	VBZ
cord-321401-w4ne60fn	52	5	to	to	TO
cord-321401-w4ne60fn	52	6	be	be	VB
cord-321401-w4ne60fn	52	7	converted	convert	VBN
cord-321401-w4ne60fn	52	8	into	into	IN
cord-321401-w4ne60fn	52	9	the	the	DT
cord-321401-w4ne60fn	52	10	active	active	JJ
cord-321401-w4ne60fn	52	11	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	52	12	)	)	-RRB-
cord-321401-w4ne60fn	52	13	2	2	CD
cord-321401-w4ne60fn	52	14	D	d	NN
cord-321401-w4ne60fn	52	15	by	by	IN
cord-321401-w4ne60fn	52	16	25-hydroxyvitamin	25-hydroxyvitamin	CD
cord-321401-w4ne60fn	52	17	D-1α	d-1α	NN
cord-321401-w4ne60fn	52	18	-	-	HYPH
cord-321401-w4ne60fn	52	19	hydroxylase	hydroxylase	NN
cord-321401-w4ne60fn	52	20	(	(	-LRB-
cord-321401-w4ne60fn	52	21	CYP27B1	cyp27b1	NN
cord-321401-w4ne60fn	52	22	)	)	-RRB-
cord-321401-w4ne60fn	52	23	in	in	IN
cord-321401-w4ne60fn	52	24	the	the	DT
cord-321401-w4ne60fn	52	25	kidney	kidney	NN
cord-321401-w4ne60fn	52	26	and	and	CC
cord-321401-w4ne60fn	52	27	in	in	IN
cord-321401-w4ne60fn	52	28	other	other	JJ
cord-321401-w4ne60fn	52	29	cells	cell	NNS
cord-321401-w4ne60fn	52	30	,	,	,
cord-321401-w4ne60fn	52	31	including	include	VBG
cord-321401-w4ne60fn	52	32	several	several	JJ
cord-321401-w4ne60fn	52	33	immune	immune	NN
cord-321401-w4ne60fn	52	34	-	-	HYPH
cord-321401-w4ne60fn	52	35	and	and	CC
cord-321401-w4ne60fn	52	36	epithelial	epithelial	JJ
cord-321401-w4ne60fn	52	37	cells	cell	NNS
cord-321401-w4ne60fn	52	38	(	(	-LRB-
cord-321401-w4ne60fn	52	39	34	34	CD
cord-321401-w4ne60fn	52	40	)	)	-RRB-
cord-321401-w4ne60fn	52	41	(	(	-LRB-
cord-321401-w4ne60fn	52	42	35	35	CD
cord-321401-w4ne60fn	52	43	)	)	-RRB-
cord-321401-w4ne60fn	52	44	(	(	-LRB-
cord-321401-w4ne60fn	52	45	36	36	CD
cord-321401-w4ne60fn	52	46	)	)	-RRB-
cord-321401-w4ne60fn	52	47	(	(	-LRB-
cord-321401-w4ne60fn	52	48	37	37	CD
cord-321401-w4ne60fn	52	49	)	)	-RRB-
cord-321401-w4ne60fn	52	50	(	(	-LRB-
cord-321401-w4ne60fn	52	51	38	38	CD
cord-321401-w4ne60fn	52	52	)	)	-RRB-
cord-321401-w4ne60fn	52	53	(	(	-LRB-
cord-321401-w4ne60fn	52	54	39	39	CD
cord-321401-w4ne60fn	52	55	)	)	-RRB-
cord-321401-w4ne60fn	52	56	(	(	-LRB-
cord-321401-w4ne60fn	52	57	40	40	CD
cord-321401-w4ne60fn	52	58	)	)	-RRB-
cord-321401-w4ne60fn	52	59	.	.	.
cord-321401-w4ne60fn	53	1	1,25(OH	1,25(oh	LS
cord-321401-w4ne60fn	53	2	)	)	-RRB-
cord-321401-w4ne60fn	54	1	2	2	LS
cord-321401-w4ne60fn	54	2	D	d	NN
cord-321401-w4ne60fn	54	3	regulates	regulate	VBZ
cord-321401-w4ne60fn	54	4	expression	expression	NN
cord-321401-w4ne60fn	54	5	of	of	IN
cord-321401-w4ne60fn	54	6	several	several	JJ
cord-321401-w4ne60fn	54	7	genes	gene	NNS
cord-321401-w4ne60fn	54	8	by	by	IN
cord-321401-w4ne60fn	54	9	binding	bind	VBG
cord-321401-w4ne60fn	54	10	the	the	DT
cord-321401-w4ne60fn	54	11	nuclear	nuclear	JJ
cord-321401-w4ne60fn	54	12	VDR	VDR	NNP
cord-321401-w4ne60fn	54	13	,	,	,
cord-321401-w4ne60fn	54	14	which	which	WDT
cord-321401-w4ne60fn	54	15	heterodimerizes	heterodimerize	VBD
cord-321401-w4ne60fn	54	16	with	with	IN
cord-321401-w4ne60fn	54	17	the	the	DT
cord-321401-w4ne60fn	54	18	retinoic	retinoic	JJ
cord-321401-w4ne60fn	54	19	acid	acid	NN
cord-321401-w4ne60fn	54	20	receptor	receptor	NN
cord-321401-w4ne60fn	54	21	(	(	-LRB-
cord-321401-w4ne60fn	54	22	RXR	rxr	UH
cord-321401-w4ne60fn	54	23	)	)	-RRB-
cord-321401-w4ne60fn	54	24	to	to	TO
cord-321401-w4ne60fn	54	25	interact	interact	VB
cord-321401-w4ne60fn	54	26	with	with	IN
cord-321401-w4ne60fn	54	27	vitamin	vitamin	NN
cord-321401-w4ne60fn	54	28	D	d	NN
cord-321401-w4ne60fn	54	29	response	response	NN
cord-321401-w4ne60fn	54	30	elements	element	NNS
cord-321401-w4ne60fn	54	31	(	(	-LRB-
cord-321401-w4ne60fn	54	32	VDREs	VDREs	NNP
cord-321401-w4ne60fn	54	33	)	)	-RRB-
cord-321401-w4ne60fn	54	34	that	that	WDT
cord-321401-w4ne60fn	54	35	are	be	VBP
cord-321401-w4ne60fn	54	36	present	present	JJ
cord-321401-w4ne60fn	54	37	on	on	IN
cord-321401-w4ne60fn	54	38	the	the	DT
cord-321401-w4ne60fn	54	39	promoter	promoter	NN
cord-321401-w4ne60fn	54	40	region	region	NN
cord-321401-w4ne60fn	54	41	of	of	IN
cord-321401-w4ne60fn	54	42	these	these	DT
cord-321401-w4ne60fn	54	43	genes	gene	NNS
cord-321401-w4ne60fn	54	44	(	(	-LRB-
cord-321401-w4ne60fn	54	45	1	1	CD
cord-321401-w4ne60fn	54	46	,	,	,
cord-321401-w4ne60fn	54	47	2	2	CD
cord-321401-w4ne60fn	54	48	)	)	-RRB-
cord-321401-w4ne60fn	54	49	.	.	.
cord-321401-w4ne60fn	55	1	VDR	VDR	NNP
cord-321401-w4ne60fn	55	2	is	be	VBZ
cord-321401-w4ne60fn	55	3	most	most	RBS
cord-321401-w4ne60fn	55	4	abundantly	abundantly	RB
cord-321401-w4ne60fn	55	5	expressed	express	VBN
cord-321401-w4ne60fn	55	6	in	in	IN
cord-321401-w4ne60fn	55	7	intestinal	intestinal	JJ
cord-321401-w4ne60fn	55	8	enterocytes	enterocyte	NNS
cord-321401-w4ne60fn	55	9	,	,	,
cord-321401-w4ne60fn	55	10	pancreatic	pancreatic	JJ
cord-321401-w4ne60fn	55	11	islets	islet	NNS
cord-321401-w4ne60fn	55	12	,	,	,
cord-321401-w4ne60fn	55	13	renal	renal	JJ
cord-321401-w4ne60fn	55	14	distal	distal	JJ
cord-321401-w4ne60fn	55	15	tubules	tubule	NNS
cord-321401-w4ne60fn	55	16	and	and	CC
cord-321401-w4ne60fn	55	17	osteoblasts	osteoblast	NNS
cord-321401-w4ne60fn	55	18	,	,	,
cord-321401-w4ne60fn	55	19	but	but	CC
cord-321401-w4ne60fn	55	20	is	be	VBZ
cord-321401-w4ne60fn	55	21	also	also	RB
cord-321401-w4ne60fn	55	22	present	present	JJ
cord-321401-w4ne60fn	55	23	at	at	IN
cord-321401-w4ne60fn	55	24	lower	low	JJR
cord-321401-w4ne60fn	55	25	levels	level	NNS
cord-321401-w4ne60fn	55	26	in	in	IN
cord-321401-w4ne60fn	55	27	most	most	JJS
cord-321401-w4ne60fn	55	28	other	other	JJ
cord-321401-w4ne60fn	55	29	tissues	tissue	NNS
cord-321401-w4ne60fn	55	30	and	and	CC
cord-321401-w4ne60fn	55	31	several	several	JJ
cord-321401-w4ne60fn	55	32	other	other	JJ
cord-321401-w4ne60fn	55	33	epithelial	epithelial	NN
cord-321401-w4ne60fn	55	34	-	-	HYPH
cord-321401-w4ne60fn	55	35	and	and	CC
cord-321401-w4ne60fn	55	36	immune	immune	JJ
cord-321401-w4ne60fn	55	37	cells	cell	NNS
cord-321401-w4ne60fn	55	38	(	(	-LRB-
cord-321401-w4ne60fn	55	39	41	41	CD
cord-321401-w4ne60fn	55	40	)	)	-RRB-
cord-321401-w4ne60fn	55	41	(	(	-LRB-
cord-321401-w4ne60fn	55	42	42	42	CD
cord-321401-w4ne60fn	55	43	)	)	-RRB-
cord-321401-w4ne60fn	56	1	(	(	-LRB-
cord-321401-w4ne60fn	56	2	43	43	CD
cord-321401-w4ne60fn	56	3	)	)	-RRB-
cord-321401-w4ne60fn	56	4	(	(	-LRB-
cord-321401-w4ne60fn	56	5	44	44	CD
cord-321401-w4ne60fn	56	6	)	)	-RRB-
cord-321401-w4ne60fn	56	7	(	(	-LRB-
cord-321401-w4ne60fn	56	8	45	45	CD
cord-321401-w4ne60fn	56	9	)	)	-RRB-
cord-321401-w4ne60fn	56	10	.	.	.
cord-321401-w4ne60fn	57	1	Expression	expression	NN
cord-321401-w4ne60fn	57	2	of	of	IN
cord-321401-w4ne60fn	57	3	VDR	VDR	NNP
cord-321401-w4ne60fn	57	4	is	be	VBZ
cord-321401-w4ne60fn	57	5	classically	classically	RB
cord-321401-w4ne60fn	57	6	regulated	regulate	VBN
cord-321401-w4ne60fn	57	7	by	by	IN
cord-321401-w4ne60fn	57	8	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	57	9	)	)	-RRB-
cord-321401-w4ne60fn	57	10	2	2	CD
cord-321401-w4ne60fn	57	11	D	d	NN
cord-321401-w4ne60fn	57	12	,	,	,
cord-321401-w4ne60fn	57	13	growth	growth	NN
cord-321401-w4ne60fn	57	14	factors	factor	NNS
cord-321401-w4ne60fn	57	15	and	and	CC
cord-321401-w4ne60fn	57	16	hormones	hormone	NNS
cord-321401-w4ne60fn	57	17	such	such	JJ
cord-321401-w4ne60fn	57	18	as	as	IN
cord-321401-w4ne60fn	57	19	FGF-23	FGF-23	NNPS
cord-321401-w4ne60fn	57	20	and	and	CC
cord-321401-w4ne60fn	57	21	PTH	PTH	NNP
cord-321401-w4ne60fn	57	22	,	,	,
cord-321401-w4ne60fn	57	23	respectively	respectively	RB
cord-321401-w4ne60fn	57	24	,	,	,
cord-321401-w4ne60fn	57	25	circulating	circulate	VBG
cord-321401-w4ne60fn	57	26	calcium	calcium	NN
cord-321401-w4ne60fn	57	27	levels	level	NNS
cord-321401-w4ne60fn	57	28	,	,	,
cord-321401-w4ne60fn	57	29	bile	bile	NN
cord-321401-w4ne60fn	57	30	acids	acid	NNS
cord-321401-w4ne60fn	57	31	,	,	,
cord-321401-w4ne60fn	57	32	transcriptional	transcriptional	JJ
cord-321401-w4ne60fn	57	33	co	co	NNS
cord-321401-w4ne60fn	57	34	-	-	NNS
cord-321401-w4ne60fn	57	35	activators	activator	NNS
cord-321401-w4ne60fn	57	36	/	/	SYM
cord-321401-w4ne60fn	57	37	repressors	repressor	NNS
cord-321401-w4ne60fn	57	38	,	,	,
cord-321401-w4ne60fn	57	39	and	and	CC
cord-321401-w4ne60fn	57	40	genetic	genetic	JJ
cord-321401-w4ne60fn	57	41	-	-	HYPH
cord-321401-w4ne60fn	57	42	and	and	CC
cord-321401-w4ne60fn	57	43	epigenetic	epigenetic	JJ
cord-321401-w4ne60fn	57	44	modifications	modification	NNS
cord-321401-w4ne60fn	57	45	,	,	,
cord-321401-w4ne60fn	57	46	which	which	WDT
cord-321401-w4ne60fn	57	47	is	be	VBZ
cord-321401-w4ne60fn	57	48	tissue	tissue	NN
cord-321401-w4ne60fn	57	49	specific	specific	JJ
cord-321401-w4ne60fn	57	50	(	(	-LRB-
cord-321401-w4ne60fn	57	51	46	46	CD
cord-321401-w4ne60fn	57	52	)	)	-RRB-
cord-321401-w4ne60fn	57	53	(	(	-LRB-
cord-321401-w4ne60fn	57	54	47	47	CD
cord-321401-w4ne60fn	57	55	)	)	-RRB-
cord-321401-w4ne60fn	57	56	(	(	-LRB-
cord-321401-w4ne60fn	57	57	48	48	CD
cord-321401-w4ne60fn	57	58	)	)	-RRB-
cord-321401-w4ne60fn	57	59	(	(	-LRB-
cord-321401-w4ne60fn	57	60	49	49	CD
cord-321401-w4ne60fn	57	61	)	)	-RRB-
cord-321401-w4ne60fn	57	62	.	.	.
cord-321401-w4ne60fn	58	1	1,25(OH	1,25(oh	LS
cord-321401-w4ne60fn	58	2	)	)	-RRB-
cord-321401-w4ne60fn	59	1	2	2	LS
cord-321401-w4ne60fn	59	2	D	D	NNP
cord-321401-w4ne60fn	59	3	regulates	regulate	VBZ
cord-321401-w4ne60fn	59	4	its	-PRON-	PRP$
cord-321401-w4ne60fn	59	5	own	own	JJ
cord-321401-w4ne60fn	59	6	negative	negative	JJ
cord-321401-w4ne60fn	59	7	feedback	feedback	NN
cord-321401-w4ne60fn	59	8	by	by	IN
cord-321401-w4ne60fn	59	9	several	several	JJ
cord-321401-w4ne60fn	59	10	mechanisms	mechanism	NNS
cord-321401-w4ne60fn	59	11	,	,	,
cord-321401-w4ne60fn	59	12	including	include	VBG
cord-321401-w4ne60fn	59	13	induction	induction	NN
cord-321401-w4ne60fn	59	14	of	of	IN
cord-321401-w4ne60fn	59	15	expression	expression	NN
cord-321401-w4ne60fn	59	16	of	of	IN
cord-321401-w4ne60fn	59	17	the	the	DT
cord-321401-w4ne60fn	59	18	catabolic	catabolic	JJ
cord-321401-w4ne60fn	59	19	enzymes	enzyme	NNS
cord-321401-w4ne60fn	59	20	25-hydroxyvitamin	25-hydroxyvitamin	CD
cord-321401-w4ne60fn	59	21	D-24-hydroxylase	D-24-hydroxylase	NNP
cord-321401-w4ne60fn	59	22	(	(	-LRB-
cord-321401-w4ne60fn	59	23	CYP24A1	CYP24A1	NNP
cord-321401-w4ne60fn	59	24	)	)	-RRB-
cord-321401-w4ne60fn	59	25	and	and	CC
cord-321401-w4ne60fn	59	26	CYP3A4	CYP3A4	NNP
cord-321401-w4ne60fn	59	27	(	(	-LRB-
cord-321401-w4ne60fn	59	28	50	50	CD
cord-321401-w4ne60fn	59	29	,	,	,
cord-321401-w4ne60fn	59	30	51	51	CD
cord-321401-w4ne60fn	59	31	)	)	-RRB-
cord-321401-w4ne60fn	59	32	.	.	.
cord-321401-w4ne60fn	60	1	CYP24A1	CYP24A1	NNP
cord-321401-w4ne60fn	60	2	is	be	VBZ
cord-321401-w4ne60fn	60	3	expressed	express	VBN
cord-321401-w4ne60fn	60	4	in	in	IN
cord-321401-w4ne60fn	60	5	most	most	JJS
cord-321401-w4ne60fn	60	6	tissues	tissue	NNS
cord-321401-w4ne60fn	60	7	and	and	CC
cord-321401-w4ne60fn	60	8	converts	convert	VBZ
cord-321401-w4ne60fn	60	9	both	both	DT
cord-321401-w4ne60fn	60	10	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	60	11	and	and	CC
cord-321401-w4ne60fn	60	12	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	60	13	)	)	-RRB-
cord-321401-w4ne60fn	60	14	2	2	CD
cord-321401-w4ne60fn	60	15	D	d	NN
cord-321401-w4ne60fn	60	16	into	into	IN
cord-321401-w4ne60fn	60	17	23,25(OH	23,25(oh	CD
cord-321401-w4ne60fn	60	18	)	)	-RRB-
cord-321401-w4ne60fn	60	19	2	2	CD
cord-321401-w4ne60fn	60	20	D	d	NN
cord-321401-w4ne60fn	60	21	or	or	CC
cord-321401-w4ne60fn	60	22	24,25(OH	24,25(oh	CD
cord-321401-w4ne60fn	60	23	)	)	-RRB-
cord-321401-w4ne60fn	60	24	2	2	CD
cord-321401-w4ne60fn	60	25	D	d	NN
cord-321401-w4ne60fn	60	26	and	and	CC
cord-321401-w4ne60fn	60	27	1,23,25(OH	1,23,25(oh	CD
cord-321401-w4ne60fn	60	28	)	)	-RRB-
cord-321401-w4ne60fn	60	29	3	3	CD
cord-321401-w4ne60fn	60	30	D	d	NN
cord-321401-w4ne60fn	60	31	or	or	CC
cord-321401-w4ne60fn	60	32	1,24,25(OH	1,24,25(oh	CD
cord-321401-w4ne60fn	60	33	)	)	-RRB-
cord-321401-w4ne60fn	60	34	3	3	CD
cord-321401-w4ne60fn	60	35	D	d	NN
cord-321401-w4ne60fn	60	36	,	,	,
cord-321401-w4ne60fn	60	37	respectively	respectively	RB
cord-321401-w4ne60fn	60	38	(	(	-LRB-
cord-321401-w4ne60fn	60	39	dependent	dependent	JJ
cord-321401-w4ne60fn	60	40	on	on	IN
cord-321401-w4ne60fn	60	41	whether	whether	IN
cord-321401-w4ne60fn	60	42	CYP24A1	CYP24A1	NNP
cord-321401-w4ne60fn	60	43	hydroxylates	hydroxylate	NNS
cord-321401-w4ne60fn	60	44	at	at	IN
cord-321401-w4ne60fn	60	45	C-23	C-23	NNP
cord-321401-w4ne60fn	60	46	or	or	CC
cord-321401-w4ne60fn	60	47	at	at	IN
cord-321401-w4ne60fn	60	48	C-24	C-24	NNP
cord-321401-w4ne60fn	60	49	)	)	-RRB-
cord-321401-w4ne60fn	60	50	.	.	.
cord-321401-w4ne60fn	61	1	These	these	DT
cord-321401-w4ne60fn	61	2	are	be	VBP
cord-321401-w4ne60fn	61	3	further	further	RB
cord-321401-w4ne60fn	61	4	converted	convert	VBN
cord-321401-w4ne60fn	61	5	into	into	IN
cord-321401-w4ne60fn	61	6	metabolites	metabolite	NNS
cord-321401-w4ne60fn	61	7	that	that	WDT
cord-321401-w4ne60fn	61	8	have	have	VBP
cord-321401-w4ne60fn	61	9	been	be	VBN
cord-321401-w4ne60fn	61	10	found	find	VBN
cord-321401-w4ne60fn	61	11	to	to	TO
cord-321401-w4ne60fn	61	12	be	be	VB
cord-321401-w4ne60fn	61	13	excreted	excrete	VBN
cord-321401-w4ne60fn	61	14	into	into	IN
cord-321401-w4ne60fn	61	15	the	the	DT
cord-321401-w4ne60fn	61	16	bile	bile	NN
cord-321401-w4ne60fn	61	17	(	(	-LRB-
cord-321401-w4ne60fn	61	18	summarized	summarize	VBN
cord-321401-w4ne60fn	61	19	in	in	IN
cord-321401-w4ne60fn	61	20	Figure	Figure	NNP
cord-321401-w4ne60fn	61	21	1	1	CD
cord-321401-w4ne60fn	61	22	)	)	-RRB-
cord-321401-w4ne60fn	61	23	(	(	-LRB-
cord-321401-w4ne60fn	61	24	50	50	CD
cord-321401-w4ne60fn	61	25	,	,	,
cord-321401-w4ne60fn	61	26	52	52	CD
cord-321401-w4ne60fn	61	27	,	,	,
cord-321401-w4ne60fn	61	28	56	56	CD
cord-321401-w4ne60fn	61	29	)	)	-RRB-
cord-321401-w4ne60fn	61	30	.	.	.
cord-321401-w4ne60fn	62	1	CYP3A4	CYP3A4	NNP
cord-321401-w4ne60fn	62	2	is	be	VBZ
cord-321401-w4ne60fn	62	3	mainly	mainly	RB
cord-321401-w4ne60fn	62	4	expressed	express	VBN
cord-321401-w4ne60fn	62	5	in	in	IN
cord-321401-w4ne60fn	62	6	the	the	DT
cord-321401-w4ne60fn	62	7	liver	liver	NN
cord-321401-w4ne60fn	62	8	and	and	CC
cord-321401-w4ne60fn	62	9	small	small	JJ
cord-321401-w4ne60fn	62	10	intestines	intestine	NNS
cord-321401-w4ne60fn	62	11	and	and	CC
cord-321401-w4ne60fn	62	12	contributes	contribute	VBZ
cord-321401-w4ne60fn	62	13	to	to	IN
cord-321401-w4ne60fn	62	14	the	the	DT
cord-321401-w4ne60fn	62	15	metabolic	metabolic	JJ
cord-321401-w4ne60fn	62	16	clearance	clearance	NN
cord-321401-w4ne60fn	62	17	of	of	IN
cord-321401-w4ne60fn	62	18	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	62	19	and	and	CC
cord-321401-w4ne60fn	62	20	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	62	21	)	)	-RRB-
cord-321401-w4ne60fn	63	1	2	2	LS
cord-321401-w4ne60fn	63	2	D	d	NN
cord-321401-w4ne60fn	63	3	by	by	IN
cord-321401-w4ne60fn	63	4	converting	convert	VBG
cord-321401-w4ne60fn	63	5	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	63	6	into	into	IN
cord-321401-w4ne60fn	63	7	4β,25(OH	4β,25(oh	CD
cord-321401-w4ne60fn	63	8	)	)	-RRB-
cord-321401-w4ne60fn	63	9	2	2	CD
cord-321401-w4ne60fn	63	10	D	d	NN
cord-321401-w4ne60fn	63	11	,	,	,
cord-321401-w4ne60fn	63	12	and	and	CC
cord-321401-w4ne60fn	63	13	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	63	14	)	)	-RRB-
cord-321401-w4ne60fn	63	15	2	2	CD
cord-321401-w4ne60fn	63	16	D	d	NN
cord-321401-w4ne60fn	63	17	into	into	IN
cord-321401-w4ne60fn	63	18	Frontiers	Frontiers	NNPS
cord-321401-w4ne60fn	63	19	in	in	IN
cord-321401-w4ne60fn	63	20	Immunology	Immunology	NNP
cord-321401-w4ne60fn	63	21	|	|	NNP
cord-321401-w4ne60fn	63	22	www.frontiersin.org	www.frontiersin.org	NNP
cord-321401-w4ne60fn	63	23	1,23R,25(OH	1,23r,25(oh	CD
cord-321401-w4ne60fn	63	24	)	)	-RRB-
cord-321401-w4ne60fn	63	25	2	2	CD
cord-321401-w4ne60fn	63	26	D	d	NN
cord-321401-w4ne60fn	63	27	or	or	CC
cord-321401-w4ne60fn	63	28	1,24S,25(OH	1,24s,25(oh	CD
cord-321401-w4ne60fn	63	29	)	)	-RRB-
cord-321401-w4ne60fn	63	30	2	2	CD
cord-321401-w4ne60fn	63	31	D	d	NN
cord-321401-w4ne60fn	63	32	(	(	-LRB-
cord-321401-w4ne60fn	63	33	51	51	CD
cord-321401-w4ne60fn	63	34	)	)	-RRB-
cord-321401-w4ne60fn	63	35	.	.	.
cord-321401-w4ne60fn	64	1	Expression	expression	NN
cord-321401-w4ne60fn	64	2	of	of	IN
cord-321401-w4ne60fn	64	3	both	both	DT
cord-321401-w4ne60fn	64	4	CYP27B1	cyp27b1	NN
cord-321401-w4ne60fn	64	5	and	and	CC
cord-321401-w4ne60fn	64	6	CYP24A1	cyp24a1	VB
cord-321401-w4ne60fn	64	7	in	in	IN
cord-321401-w4ne60fn	64	8	the	the	DT
cord-321401-w4ne60fn	64	9	kidneys	kidney	NNS
cord-321401-w4ne60fn	64	10	is	be	VBZ
cord-321401-w4ne60fn	64	11	tightly	tightly	RB
cord-321401-w4ne60fn	64	12	regulated	regulate	VBN
cord-321401-w4ne60fn	64	13	to	to	TO
cord-321401-w4ne60fn	64	14	maintain	maintain	VB
cord-321401-w4ne60fn	64	15	optimal	optimal	JJ
cord-321401-w4ne60fn	65	1	Ca	ca	NN
cord-321401-w4ne60fn	65	2	2	2	CD
cord-321401-w4ne60fn	65	3	+	+	SYM
cord-321401-w4ne60fn	65	4	-and	-and	CC
cord-321401-w4ne60fn	65	5	PO	po	NN
cord-321401-w4ne60fn	65	6	4	4	CD
cord-321401-w4ne60fn	66	1	2−	2−	JJ
cord-321401-w4ne60fn	66	2	levels	level	NNS
cord-321401-w4ne60fn	66	3	in	in	IN
cord-321401-w4ne60fn	66	4	the	the	DT
cord-321401-w4ne60fn	66	5	circulation	circulation	NN
cord-321401-w4ne60fn	66	6	,	,	,
cord-321401-w4ne60fn	66	7	which	which	WDT
cord-321401-w4ne60fn	66	8	are	be	VBP
cord-321401-w4ne60fn	66	9	important	important	JJ
cord-321401-w4ne60fn	66	10	for	for	IN
cord-321401-w4ne60fn	66	11	bone	bone	NN
cord-321401-w4ne60fn	66	12	mineralization	mineralization	NN
cord-321401-w4ne60fn	66	13	(	(	-LRB-
cord-321401-w4ne60fn	66	14	57	57	CD
cord-321401-w4ne60fn	66	15	)	)	-RRB-
cord-321401-w4ne60fn	66	16	.	.	.
cord-321401-w4ne60fn	67	1	In	in	IN
cord-321401-w4ne60fn	67	2	short	short	JJ
cord-321401-w4ne60fn	67	3	,	,	,
cord-321401-w4ne60fn	67	4	in	in	IN
cord-321401-w4ne60fn	67	5	response	response	NN
cord-321401-w4ne60fn	67	6	to	to	IN
cord-321401-w4ne60fn	67	7	low	low	JJ
cord-321401-w4ne60fn	67	8	Ca	Ca	NNP
cord-321401-w4ne60fn	67	9	2	2	CD
cord-321401-w4ne60fn	67	10	+	+	SYM
cord-321401-w4ne60fn	67	11	levels	level	NNS
cord-321401-w4ne60fn	67	12	,	,	,
cord-321401-w4ne60fn	67	13	parathyroid	parathyroid	JJ
cord-321401-w4ne60fn	67	14	hormone	hormone	NN
cord-321401-w4ne60fn	67	15	(	(	-LRB-
cord-321401-w4ne60fn	67	16	PTH	PTH	NNP
cord-321401-w4ne60fn	67	17	)	)	-RRB-
cord-321401-w4ne60fn	67	18	is	be	VBZ
cord-321401-w4ne60fn	67	19	secreted	secrete	VBN
cord-321401-w4ne60fn	67	20	by	by	IN
cord-321401-w4ne60fn	67	21	the	the	DT
cord-321401-w4ne60fn	67	22	pituitary	pituitary	JJ
cord-321401-w4ne60fn	67	23	glands	gland	NNS
cord-321401-w4ne60fn	67	24	,	,	,
cord-321401-w4ne60fn	67	25	which	which	WDT
cord-321401-w4ne60fn	67	26	in	in	IN
cord-321401-w4ne60fn	67	27	turn	turn	NN
cord-321401-w4ne60fn	67	28	reduces	reduce	VBZ
cord-321401-w4ne60fn	68	1	Ca	ca	NN
cord-321401-w4ne60fn	68	2	2	2	CD
cord-321401-w4ne60fn	68	3	+	+	CC
cord-321401-w4ne60fn	68	4	excretion	excretion	NN
cord-321401-w4ne60fn	68	5	and	and	CC
cord-321401-w4ne60fn	68	6	reabsorption	reabsorption	NN
cord-321401-w4ne60fn	68	7	of	of	IN
cord-321401-w4ne60fn	68	8	PO	PO	NNP
cord-321401-w4ne60fn	68	9	4	4	CD
cord-321401-w4ne60fn	68	10	2−	2−	CD
cord-321401-w4ne60fn	68	11	(	(	-LRB-
cord-321401-w4ne60fn	68	12	57	57	CD
cord-321401-w4ne60fn	68	13	)	)	-RRB-
cord-321401-w4ne60fn	68	14	.	.	.
cord-321401-w4ne60fn	69	1	PTH	PTH	NNP
cord-321401-w4ne60fn	69	2	further	further	RB
cord-321401-w4ne60fn	69	3	induces	induce	VBZ
cord-321401-w4ne60fn	69	4	expression	expression	NN
cord-321401-w4ne60fn	69	5	of	of	IN
cord-321401-w4ne60fn	69	6	CYP27B1	cyp27b1	NN
cord-321401-w4ne60fn	69	7	and	and	CC
cord-321401-w4ne60fn	69	8	represses	repress	VBZ
cord-321401-w4ne60fn	69	9	expression	expression	NN
cord-321401-w4ne60fn	69	10	of	of	IN
cord-321401-w4ne60fn	69	11	CYP24A1	CYP24A1	NNP
cord-321401-w4ne60fn	69	12	in	in	IN
cord-321401-w4ne60fn	69	13	the	the	DT
cord-321401-w4ne60fn	69	14	kidneys	kidney	NNS
cord-321401-w4ne60fn	69	15	(	(	-LRB-
cord-321401-w4ne60fn	69	16	57	57	CD
cord-321401-w4ne60fn	69	17	)	)	-RRB-
cord-321401-w4ne60fn	69	18	.	.	.
cord-321401-w4ne60fn	70	1	This	this	DT
cord-321401-w4ne60fn	70	2	will	will	MD
cord-321401-w4ne60fn	70	3	increase	increase	VB
cord-321401-w4ne60fn	70	4	the	the	DT
cord-321401-w4ne60fn	70	5	levels	level	NNS
cord-321401-w4ne60fn	70	6	of	of	IN
cord-321401-w4ne60fn	70	7	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	70	8	)	)	-RRB-
cord-321401-w4ne60fn	70	9	2	2	CD
cord-321401-w4ne60fn	70	10	D	d	NN
cord-321401-w4ne60fn	70	11	in	in	IN
cord-321401-w4ne60fn	70	12	the	the	DT
cord-321401-w4ne60fn	70	13	circulation	circulation	NN
cord-321401-w4ne60fn	70	14	,	,	,
cord-321401-w4ne60fn	70	15	which	which	WDT
cord-321401-w4ne60fn	70	16	promotes	promote	VBZ
cord-321401-w4ne60fn	70	17	intestinal	intestinal	JJ
cord-321401-w4ne60fn	70	18	Ca	Ca	NNP
cord-321401-w4ne60fn	70	19	2	2	CD
cord-321401-w4ne60fn	70	20	+	+	SYM
cord-321401-w4ne60fn	70	21	and	and	CC
cord-321401-w4ne60fn	70	22	PO	PO	NNP
cord-321401-w4ne60fn	70	23	4	4	CD
cord-321401-w4ne60fn	71	1	2−	2−	JJ
cord-321401-w4ne60fn	71	2	absorption	absorption	NN
cord-321401-w4ne60fn	71	3	(	(	-LRB-
cord-321401-w4ne60fn	71	4	57	57	CD
cord-321401-w4ne60fn	71	5	)	)	-RRB-
cord-321401-w4ne60fn	71	6	.	.	.
cord-321401-w4ne60fn	72	1	These	these	DT
cord-321401-w4ne60fn	72	2	elevated	elevated	JJ
cord-321401-w4ne60fn	72	3	circulating	circulating	NN
cord-321401-w4ne60fn	73	1	Ca	ca	NN
cord-321401-w4ne60fn	73	2	2	2	CD
cord-321401-w4ne60fn	73	3	+	+	SYM
cord-321401-w4ne60fn	73	4	and	and	CC
cord-321401-w4ne60fn	73	5	PO	PO	NNP
cord-321401-w4ne60fn	73	6	4	4	CD
cord-321401-w4ne60fn	74	1	2−	2−	JJ
cord-321401-w4ne60fn	74	2	levels	level	NNS
cord-321401-w4ne60fn	74	3	will	will	MD
cord-321401-w4ne60fn	74	4	subsequently	subsequently	RB
cord-321401-w4ne60fn	74	5	induce	induce	VB
cord-321401-w4ne60fn	74	6	expression	expression	NN
cord-321401-w4ne60fn	74	7	of	of	IN
cord-321401-w4ne60fn	74	8	fibroblast	fibroblast	NN
cord-321401-w4ne60fn	74	9	growth	growth	NN
cord-321401-w4ne60fn	74	10	factor	factor	NN
cord-321401-w4ne60fn	74	11	23	23	CD
cord-321401-w4ne60fn	74	12	(	(	-LRB-
cord-321401-w4ne60fn	74	13	FGF-23	FGF-23	NNP
cord-321401-w4ne60fn	74	14	)	)	-RRB-
cord-321401-w4ne60fn	74	15	in	in	IN
cord-321401-w4ne60fn	74	16	osteocytes	osteocyte	NNS
cord-321401-w4ne60fn	74	17	and	and	CC
cord-321401-w4ne60fn	74	18	osteoblasts	osteoblast	NNS
cord-321401-w4ne60fn	74	19	and	and	CC
cord-321401-w4ne60fn	74	20	impair	impair	VB
cord-321401-w4ne60fn	74	21	secretion	secretion	NN
cord-321401-w4ne60fn	74	22	of	of	IN
cord-321401-w4ne60fn	74	23	parathyroid	parathyroid	JJ
cord-321401-w4ne60fn	74	24	hormone	hormone	NN
cord-321401-w4ne60fn	74	25	(	(	-LRB-
cord-321401-w4ne60fn	74	26	PTH	PTH	NNP
cord-321401-w4ne60fn	74	27	)	)	-RRB-
cord-321401-w4ne60fn	74	28	by	by	IN
cord-321401-w4ne60fn	74	29	the	the	DT
cord-321401-w4ne60fn	74	30	parathyroid	parathyroid	JJ
cord-321401-w4ne60fn	74	31	glands	gland	NNS
cord-321401-w4ne60fn	74	32	(	(	-LRB-
cord-321401-w4ne60fn	74	33	3	3	CD
cord-321401-w4ne60fn	74	34	)	)	-RRB-
cord-321401-w4ne60fn	74	35	.	.	.
cord-321401-w4ne60fn	75	1	In	in	IN
cord-321401-w4ne60fn	75	2	the	the	DT
cord-321401-w4ne60fn	75	3	kidneys	kidney	NNS
cord-321401-w4ne60fn	75	4	,	,	,
cord-321401-w4ne60fn	75	5	FGF-23	FGF-23	NNP
cord-321401-w4ne60fn	75	6	suppresses	suppress	VBZ
cord-321401-w4ne60fn	75	7	expression	expression	NN
cord-321401-w4ne60fn	75	8	of	of	IN
cord-321401-w4ne60fn	75	9	CYP27B1	cyp27b1	NN
cord-321401-w4ne60fn	75	10	and	and	CC
cord-321401-w4ne60fn	75	11	induces	induce	VBZ
cord-321401-w4ne60fn	75	12	expression	expression	NN
cord-321401-w4ne60fn	75	13	of	of	IN
cord-321401-w4ne60fn	75	14	CYP24A1	CYP24A1	NNP
cord-321401-w4ne60fn	75	15	,	,	,
cord-321401-w4ne60fn	75	16	thereby	thereby	RB
cord-321401-w4ne60fn	75	17	inhibiting	inhibit	VBG
cord-321401-w4ne60fn	75	18	the	the	DT
cord-321401-w4ne60fn	75	19	synthesis	synthesis	NN
cord-321401-w4ne60fn	75	20	and	and	CC
cord-321401-w4ne60fn	75	21	promoting	promote	VBG
cord-321401-w4ne60fn	75	22	degradation	degradation	NN
cord-321401-w4ne60fn	75	23	of	of	IN
cord-321401-w4ne60fn	75	24	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	75	25	)	)	-RRB-
cord-321401-w4ne60fn	75	26	2	2	CD
cord-321401-w4ne60fn	75	27	D	d	NN
cord-321401-w4ne60fn	75	28	(	(	-LRB-
cord-321401-w4ne60fn	75	29	3	3	CD
cord-321401-w4ne60fn	75	30	)	)	-RRB-
cord-321401-w4ne60fn	75	31	.	.	.
cord-321401-w4ne60fn	76	1	These	these	DT
cord-321401-w4ne60fn	76	2	complex	complex	JJ
cord-321401-w4ne60fn	76	3	mechanisms	mechanism	NNS
cord-321401-w4ne60fn	76	4	that	that	WDT
cord-321401-w4ne60fn	76	5	explain	explain	VBP
cord-321401-w4ne60fn	76	6	how	how	WRB
cord-321401-w4ne60fn	76	7	vitamin	vitamin	NN
cord-321401-w4ne60fn	76	8	D	d	NN
cord-321401-w4ne60fn	76	9	and	and	CC
cord-321401-w4ne60fn	76	10	its	-PRON-	PRP$
cord-321401-w4ne60fn	76	11	metabolic	metabolic	JJ
cord-321401-w4ne60fn	76	12	enzymes	enzyme	NNS
cord-321401-w4ne60fn	76	13	maintain	maintain	VBP
cord-321401-w4ne60fn	76	14	sufficient	sufficient	JJ
cord-321401-w4ne60fn	77	1	Ca	ca	NN
cord-321401-w4ne60fn	77	2	2	2	CD
cord-321401-w4ne60fn	77	3	+	+	SYM
cord-321401-w4ne60fn	77	4	and	and	CC
cord-321401-w4ne60fn	77	5	PO	PO	NNP
cord-321401-w4ne60fn	77	6	4	4	CD
cord-321401-w4ne60fn	78	1	2−	2−	JJ
cord-321401-w4ne60fn	78	2	levels	level	NNS
cord-321401-w4ne60fn	78	3	in	in	IN
cord-321401-w4ne60fn	78	4	the	the	DT
cord-321401-w4ne60fn	78	5	circulation	circulation	NN
cord-321401-w4ne60fn	78	6	are	be	VBP
cord-321401-w4ne60fn	78	7	more	more	RBR
cord-321401-w4ne60fn	78	8	extensively	extensively	RB
cord-321401-w4ne60fn	78	9	discussed	discuss	VBN
cord-321401-w4ne60fn	78	10	by	by	IN
cord-321401-w4ne60fn	78	11	Quarles	Quarles	NNP
cord-321401-w4ne60fn	78	12	et	et	NNP
cord-321401-w4ne60fn	78	13	al	al	NNP
cord-321401-w4ne60fn	78	14	.	.	.
cord-321401-w4ne60fn	79	1	(	(	-LRB-
cord-321401-w4ne60fn	79	2	57	57	CD
cord-321401-w4ne60fn	79	3	)	)	-RRB-
cord-321401-w4ne60fn	79	4	.	.	.
cord-321401-w4ne60fn	80	1	In	in	IN
cord-321401-w4ne60fn	80	2	summary	summary	NN
cord-321401-w4ne60fn	80	3	,	,	,
cord-321401-w4ne60fn	80	4	it	-PRON-	PRP
cord-321401-w4ne60fn	80	5	has	have	VBZ
cord-321401-w4ne60fn	80	6	become	become	VBN
cord-321401-w4ne60fn	80	7	increasingly	increasingly	RB
cord-321401-w4ne60fn	80	8	evident	evident	JJ
cord-321401-w4ne60fn	80	9	that	that	IN
cord-321401-w4ne60fn	80	10	the	the	DT
cord-321401-w4ne60fn	80	11	effects	effect	NNS
cord-321401-w4ne60fn	80	12	of	of	IN
cord-321401-w4ne60fn	80	13	vitamin	vitamin	NN
cord-321401-w4ne60fn	80	14	D	d	NN
cord-321401-w4ne60fn	80	15	are	be	VBP
cord-321401-w4ne60fn	80	16	not	not	RB
cord-321401-w4ne60fn	80	17	limited	limit	VBN
cord-321401-w4ne60fn	80	18	to	to	IN
cord-321401-w4ne60fn	80	19	homeostasis	homeostasis	NN
cord-321401-w4ne60fn	80	20	of	of	IN
cord-321401-w4ne60fn	80	21	Ca	Ca	NNP
cord-321401-w4ne60fn	80	22	2	2	CD
cord-321401-w4ne60fn	81	1	+	+	CC
cord-321401-w4ne60fn	82	1	and	and	CC
cord-321401-w4ne60fn	82	2	PO	PO	NNP
cord-321401-w4ne60fn	82	3	4	4	CD
cord-321401-w4ne60fn	82	4	2−	2−	CD
cord-321401-w4ne60fn	82	5	and	and	CC
cord-321401-w4ne60fn	82	6	bone	bone	NN
cord-321401-w4ne60fn	82	7	mineralization	mineralization	NN
cord-321401-w4ne60fn	82	8	,	,	,
cord-321401-w4ne60fn	82	9	because	because	IN
cord-321401-w4ne60fn	82	10	several	several	JJ
cord-321401-w4ne60fn	82	11	extra	extra	JJ
cord-321401-w4ne60fn	82	12	-	-	JJ
cord-321401-w4ne60fn	82	13	renal	renal	JJ
cord-321401-w4ne60fn	82	14	cells	cell	NNS
cord-321401-w4ne60fn	82	15	such	such	JJ
cord-321401-w4ne60fn	82	16	as	as	IN
cord-321401-w4ne60fn	82	17	airway	airway	NN
cord-321401-w4ne60fn	82	18	epithelial	epithelial	JJ
cord-321401-w4ne60fn	82	19	cells	cell	NNS
cord-321401-w4ne60fn	82	20	and	and	CC
cord-321401-w4ne60fn	82	21	immune	immune	JJ
cord-321401-w4ne60fn	82	22	cells	cell	NNS
cord-321401-w4ne60fn	82	23	express	express	VBP
cord-321401-w4ne60fn	82	24	the	the	DT
cord-321401-w4ne60fn	82	25	VDR	VDR	NNP
cord-321401-w4ne60fn	82	26	and	and	CC
cord-321401-w4ne60fn	82	27	are	be	VBP
cord-321401-w4ne60fn	82	28	capable	capable	JJ
cord-321401-w4ne60fn	82	29	of	of	IN
cord-321401-w4ne60fn	82	30	converting	convert	VBG
cord-321401-w4ne60fn	82	31	circulating	circulate	VBG
cord-321401-w4ne60fn	82	32	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	82	33	into	into	IN
cord-321401-w4ne60fn	82	34	the	the	DT
cord-321401-w4ne60fn	82	35	active	active	JJ
cord-321401-w4ne60fn	82	36	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	82	37	)	)	-RRB-
cord-321401-w4ne60fn	82	38	2	2	CD
cord-321401-w4ne60fn	82	39	D	d	NN
cord-321401-w4ne60fn	82	40	metabolite	metabolite	NN
cord-321401-w4ne60fn	82	41	.	.	.
cord-321401-w4ne60fn	83	1	Local	local	JJ
cord-321401-w4ne60fn	83	2	levels	level	NNS
cord-321401-w4ne60fn	83	3	and	and	CC
cord-321401-w4ne60fn	83	4	activity	activity	NN
cord-321401-w4ne60fn	83	5	of	of	IN
cord-321401-w4ne60fn	83	6	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	83	7	)	)	-RRB-
cord-321401-w4ne60fn	83	8	2	2	CD
cord-321401-w4ne60fn	83	9	D	d	NN
cord-321401-w4ne60fn	83	10	are	be	VBP
cord-321401-w4ne60fn	83	11	in	in	IN
cord-321401-w4ne60fn	83	12	part	part	NN
cord-321401-w4ne60fn	83	13	determined	determine	VBN
cord-321401-w4ne60fn	83	14	by	by	IN
cord-321401-w4ne60fn	83	15	expression	expression	NN
cord-321401-w4ne60fn	83	16	of	of	IN
cord-321401-w4ne60fn	83	17	VDR	VDR	NNP
cord-321401-w4ne60fn	83	18	and	and	CC
cord-321401-w4ne60fn	83	19	the	the	DT
cord-321401-w4ne60fn	83	20	equilibrium	equilibrium	NN
cord-321401-w4ne60fn	83	21	between	between	IN
cord-321401-w4ne60fn	83	22	the	the	DT
cord-321401-w4ne60fn	83	23	vitamin	vitamin	NN
cord-321401-w4ne60fn	83	24	D	d	NN
cord-321401-w4ne60fn	83	25	metabolic	metabolic	JJ
cord-321401-w4ne60fn	83	26	enzymes	enzyme	NNS
cord-321401-w4ne60fn	83	27	CYP27B1	cyp27b1	VBP
cord-321401-w4ne60fn	83	28	and	and	CC
cord-321401-w4ne60fn	83	29	CYP24A1	CYP24A1	NNP
cord-321401-w4ne60fn	83	30	.	.	.
cord-321401-w4ne60fn	84	1	It	-PRON-	PRP
cord-321401-w4ne60fn	84	2	is	be	VBZ
cord-321401-w4ne60fn	84	3	important	important	JJ
cord-321401-w4ne60fn	84	4	to	to	TO
cord-321401-w4ne60fn	84	5	realize	realize	VB
cord-321401-w4ne60fn	84	6	that	that	IN
cord-321401-w4ne60fn	84	7	mucosal	mucosal	JJ
cord-321401-w4ne60fn	84	8	expression	expression	NN
cord-321401-w4ne60fn	84	9	of	of	IN
cord-321401-w4ne60fn	84	10	CYP24A1	CYP24A1	NNP
cord-321401-w4ne60fn	84	11	,	,	,
cord-321401-w4ne60fn	84	12	CYP27B1	cyp27b1	NN
cord-321401-w4ne60fn	84	13	and	and	CC
cord-321401-w4ne60fn	84	14	also	also	RB
cord-321401-w4ne60fn	84	15	VDR	VDR	NNP
cord-321401-w4ne60fn	84	16	can	can	MD
cord-321401-w4ne60fn	84	17	be	be	VB
cord-321401-w4ne60fn	84	18	affected	affect	VBN
cord-321401-w4ne60fn	84	19	by	by	IN
cord-321401-w4ne60fn	84	20	several	several	JJ
cord-321401-w4ne60fn	84	21	disease	disease	NN
cord-321401-w4ne60fn	84	22	-	-	HYPH
cord-321401-w4ne60fn	84	23	associated	associate	VBN
cord-321401-w4ne60fn	84	24	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	84	25	mediators	mediator	NNS
cord-321401-w4ne60fn	84	26	,	,	,
cord-321401-w4ne60fn	84	27	toxicants	toxicant	NNS
cord-321401-w4ne60fn	84	28	and	and	CC
cord-321401-w4ne60fn	84	29	pathogens	pathogen	NNS
cord-321401-w4ne60fn	84	30	,	,	,
cord-321401-w4ne60fn	84	31	summarized	summarize	VBN
cord-321401-w4ne60fn	84	32	in	in	IN
cord-321401-w4ne60fn	84	33	Table	Table	NNP
cord-321401-w4ne60fn	84	34	1	1	CD
cord-321401-w4ne60fn	84	35	.	.	.
cord-321401-w4ne60fn	85	1	As	as	IN
cord-321401-w4ne60fn	85	2	a	a	DT
cord-321401-w4ne60fn	85	3	consequence	consequence	NN
cord-321401-w4ne60fn	85	4	of	of	IN
cord-321401-w4ne60fn	85	5	this	this	DT
cord-321401-w4ne60fn	85	6	,	,	,
cord-321401-w4ne60fn	85	7	the	the	DT
cord-321401-w4ne60fn	85	8	local	local	JJ
cord-321401-w4ne60fn	85	9	availability	availability	NN
cord-321401-w4ne60fn	85	10	of	of	IN
cord-321401-w4ne60fn	85	11	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	85	12	)	)	-RRB-
cord-321401-w4ne60fn	85	13	2	2	CD
cord-321401-w4ne60fn	85	14	D	d	NN
cord-321401-w4ne60fn	85	15	and/or	and/or	CC
cord-321401-w4ne60fn	85	16	VDR	VDR	NNP
cord-321401-w4ne60fn	85	17	signaling	signal	VBG
cord-321401-w4ne60fn	85	18	in	in	IN
cord-321401-w4ne60fn	85	19	tissues	tissue	NNS
cord-321401-w4ne60fn	85	20	such	such	JJ
cord-321401-w4ne60fn	85	21	as	as	IN
cord-321401-w4ne60fn	85	22	the	the	DT
cord-321401-w4ne60fn	85	23	inflamed	inflamed	JJ
cord-321401-w4ne60fn	85	24	airways	airway	NNS
cord-321401-w4ne60fn	85	25	of	of	IN
cord-321401-w4ne60fn	85	26	patients	patient	NNS
cord-321401-w4ne60fn	85	27	that	that	WDT
cord-321401-w4ne60fn	85	28	suffer	suffer	VBP
cord-321401-w4ne60fn	85	29	from	from	IN
cord-321401-w4ne60fn	85	30	chronic	chronic	JJ
cord-321401-w4ne60fn	85	31	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	85	32	airway	airway	NN
cord-321401-w4ne60fn	85	33	diseases	disease	NNS
cord-321401-w4ne60fn	85	34	might	may	MD
cord-321401-w4ne60fn	85	35	be	be	VB
cord-321401-w4ne60fn	85	36	reduced	reduce	VBN
cord-321401-w4ne60fn	85	37	.	.	.
cord-321401-w4ne60fn	86	1	Chronic	chronic	JJ
cord-321401-w4ne60fn	86	2	lung	lung	NN
cord-321401-w4ne60fn	86	3	diseases	disease	NNS
cord-321401-w4ne60fn	86	4	are	be	VBP
cord-321401-w4ne60fn	86	5	characterized	characterize	VBN
cord-321401-w4ne60fn	86	6	by	by	IN
cord-321401-w4ne60fn	86	7	airway	airway	NN
cord-321401-w4ne60fn	86	8	inflammation	inflammation	NN
cord-321401-w4ne60fn	86	9	and	and	CC
cord-321401-w4ne60fn	86	10	impaired	impaired	JJ
cord-321401-w4ne60fn	86	11	respiratory	respiratory	JJ
cord-321401-w4ne60fn	86	12	host	host	NN
cord-321401-w4ne60fn	86	13	defense	defense	NN
cord-321401-w4ne60fn	86	14	,	,	,
cord-321401-w4ne60fn	86	15	which	which	WDT
cord-321401-w4ne60fn	86	16	is	be	VBZ
cord-321401-w4ne60fn	86	17	illustrated	illustrate	VBN
cord-321401-w4ne60fn	86	18	by	by	IN
cord-321401-w4ne60fn	86	19	the	the	DT
cord-321401-w4ne60fn	86	20	increased	increase	VBN
cord-321401-w4ne60fn	86	21	susceptibility	susceptibility	NN
cord-321401-w4ne60fn	86	22	for	for	IN
cord-321401-w4ne60fn	86	23	respiratory	respiratory	JJ
cord-321401-w4ne60fn	86	24	infections	infection	NNS
cord-321401-w4ne60fn	86	25	and	and	CC
cord-321401-w4ne60fn	86	26	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	86	27	(	(	-LRB-
cord-321401-w4ne60fn	86	28	25	25	CD
cord-321401-w4ne60fn	86	29	,	,	,
cord-321401-w4ne60fn	86	30	80	80	CD
cord-321401-w4ne60fn	86	31	,	,	,
cord-321401-w4ne60fn	86	32	81	81	CD
cord-321401-w4ne60fn	86	33	)	)	-RRB-
cord-321401-w4ne60fn	86	34	.	.	.
cord-321401-w4ne60fn	87	1	Furthermore	furthermore	RB
cord-321401-w4ne60fn	87	2	,	,	,
cord-321401-w4ne60fn	87	3	exposure	exposure	NN
cord-321401-w4ne60fn	87	4	to	to	IN
cord-321401-w4ne60fn	87	5	inhaled	inhale	VBN
cord-321401-w4ne60fn	87	6	toxicants	toxicant	NNS
cord-321401-w4ne60fn	87	7	such	such	JJ
cord-321401-w4ne60fn	87	8	as	as	IN
cord-321401-w4ne60fn	87	9	cigarette	cigarette	NN
cord-321401-w4ne60fn	87	10	smoke	smoke	NN
cord-321401-w4ne60fn	87	11	and	and	CC
cord-321401-w4ne60fn	87	12	air	air	NN
cord-321401-w4ne60fn	87	13	pollutants	pollutant	NNS
cord-321401-w4ne60fn	87	14	are	be	VBP
cord-321401-w4ne60fn	87	15	associated	associate	VBN
cord-321401-w4ne60fn	87	16	with	with	IN
cord-321401-w4ne60fn	87	17	disease	disease	NN
cord-321401-w4ne60fn	87	18	pathogenesis	pathogenesis	NN
cord-321401-w4ne60fn	87	19	and	and	CC
cord-321401-w4ne60fn	87	20	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	87	21	in	in	IN
cord-321401-w4ne60fn	87	22	COPD	COPD	NNP
cord-321401-w4ne60fn	87	23	,	,	,
cord-321401-w4ne60fn	87	24	CF	CF	NNP
cord-321401-w4ne60fn	87	25	and	and	CC
cord-321401-w4ne60fn	87	26	in	in	IN
cord-321401-w4ne60fn	87	27	asthma	asthma	NN
cord-321401-w4ne60fn	87	28	patients	patient	NNS
cord-321401-w4ne60fn	87	29	(	(	-LRB-
cord-321401-w4ne60fn	87	30	82	82	CD
cord-321401-w4ne60fn	87	31	)	)	-RRB-
cord-321401-w4ne60fn	88	1	(	(	-LRB-
cord-321401-w4ne60fn	88	2	83	83	CD
cord-321401-w4ne60fn	88	3	)	)	-RRB-
cord-321401-w4ne60fn	89	1	(	(	-LRB-
cord-321401-w4ne60fn	89	2	84	84	CD
cord-321401-w4ne60fn	89	3	)	)	-RRB-
cord-321401-w4ne60fn	89	4	.	.	.
cord-321401-w4ne60fn	90	1	It	-PRON-	PRP
cord-321401-w4ne60fn	90	2	would	would	MD
cord-321401-w4ne60fn	90	3	therefore	therefore	RB
cord-321401-w4ne60fn	90	4	be	be	VB
cord-321401-w4ne60fn	90	5	of	of	IN
cord-321401-w4ne60fn	90	6	great	great	JJ
cord-321401-w4ne60fn	90	7	interest	interest	NN
cord-321401-w4ne60fn	90	8	to	to	TO
cord-321401-w4ne60fn	90	9	investigate	investigate	VB
cord-321401-w4ne60fn	90	10	these	these	DT
cord-321401-w4ne60fn	90	11	effects	effect	NNS
cord-321401-w4ne60fn	90	12	on	on	IN
cord-321401-w4ne60fn	90	13	local	local	JJ
cord-321401-w4ne60fn	90	14	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	90	15	)	)	-RRB-
cord-321401-w4ne60fn	90	16	2	2	CD
cord-321401-w4ne60fn	90	17	D	d	NN
cord-321401-w4ne60fn	90	18	levels	level	NNS
cord-321401-w4ne60fn	90	19	and	and	CC
cord-321401-w4ne60fn	90	20	on	on	IN
cord-321401-w4ne60fn	90	21	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	90	22	)	)	-RRB-
cord-321401-w4ne60fn	90	23	2	2	CD
cord-321401-w4ne60fn	90	24	D	d	NN
cord-321401-w4ne60fn	90	25	-	-	HYPH
cord-321401-w4ne60fn	90	26	mediated	mediate	VBN
cord-321401-w4ne60fn	90	27	respiratory	respiratory	JJ
cord-321401-w4ne60fn	90	28	host	host	NN
cord-321401-w4ne60fn	90	29	defense	defense	NN
cord-321401-w4ne60fn	90	30	in	in	IN
cord-321401-w4ne60fn	90	31	the	the	DT
cord-321401-w4ne60fn	90	32	airway	airway	NN
cord-321401-w4ne60fn	90	33	mucosa	mucosa	NN
cord-321401-w4ne60fn	90	34	.	.	.
cord-321401-w4ne60fn	91	1	Studies	study	NNS
cord-321401-w4ne60fn	91	2	in	in	IN
cord-321401-w4ne60fn	91	3	airway	airway	NN
cord-321401-w4ne60fn	91	4	epithelial	epithelial	JJ
cord-321401-w4ne60fn	91	5	cells	cell	NNS
cord-321401-w4ne60fn	91	6	have	have	VBP
cord-321401-w4ne60fn	91	7	shown	show	VBN
cord-321401-w4ne60fn	91	8	that	that	DT
cord-321401-w4ne60fn	91	9	exposure	exposure	NN
cord-321401-w4ne60fn	91	10	to	to	IN
cord-321401-w4ne60fn	91	11	UV	uv	NN
cord-321401-w4ne60fn	91	12	-	-	HYPH
cord-321401-w4ne60fn	91	13	inactivated	inactivate	VBN
cord-321401-w4ne60fn	91	14	non	non	JJ
cord-321401-w4ne60fn	91	15	-	-	JJ
cord-321401-w4ne60fn	91	16	typeable	typeable	JJ
cord-321401-w4ne60fn	91	17	Haemophilus	haemophilus	NN
cord-321401-w4ne60fn	91	18	influenzae	influenzae	NN
cord-321401-w4ne60fn	91	19	(	(	-LRB-
cord-321401-w4ne60fn	91	20	NTHi	NTHi	NNS
cord-321401-w4ne60fn	91	21	)	)	-RRB-
cord-321401-w4ne60fn	91	22	increased	increase	VBN
cord-321401-w4ne60fn	91	23	expression	expression	NN
cord-321401-w4ne60fn	91	24	of	of	IN
cord-321401-w4ne60fn	91	25	the	the	DT
cord-321401-w4ne60fn	91	26	 	 	_SP
cord-321401-w4ne60fn	91	27	COGA-1A	COGA-1A	NNP
cord-321401-w4ne60fn	91	28	(	(	-LRB-
cord-321401-w4ne60fn	91	29	colon	colon	NN
cord-321401-w4ne60fn	91	30	cancer	cancer	NN
cord-321401-w4ne60fn	91	31	epithelial	epithelial	JJ
cord-321401-w4ne60fn	91	32	cell	cell	NN
cord-321401-w4ne60fn	91	33	line	line	NN
cord-321401-w4ne60fn	91	34	)	)	-RRB-
cord-321401-w4ne60fn	92	1	Trophoblasts	Trophoblasts	NNP
cord-321401-w4ne60fn	92	2	TNF	TNF	NNP
cord-321401-w4ne60fn	92	3	-	-	HYPH
cord-321401-w4ne60fn	92	4	α	α	NNP
cord-321401-w4ne60fn	92	5	;	;	:
cord-321401-w4ne60fn	92	6	IL-1β	il-1β	ADD
cord-321401-w4ne60fn	92	7	;	;	:
cord-321401-w4ne60fn	92	8	IL-6	IL-6	NNP
cord-321401-w4ne60fn	92	9	CYP24A1	cyp24a1	NN
cord-321401-w4ne60fn	92	10	↑	↑	NN
cord-321401-w4ne60fn	92	11	Macrophages	macrophages	NN
cord-321401-w4ne60fn	92	12	Macrophages	macrophage	NNS
cord-321401-w4ne60fn	92	13	(	(	-LRB-
cord-321401-w4ne60fn	92	14	derived	derive	VBN
cord-321401-w4ne60fn	92	15	from	from	IN
cord-321401-w4ne60fn	92	16	THP-1	THP-1	NNP
cord-321401-w4ne60fn	92	17	)	)	-RRB-
cord-321401-w4ne60fn	92	18	Macrophages	macrophages	NN
cord-321401-w4ne60fn	92	19	(	(	-LRB-
cord-321401-w4ne60fn	92	20	derived	derive	VBN
cord-321401-w4ne60fn	92	21	from	from	IN
cord-321401-w4ne60fn	92	22	THP-1	THP-1	NNP
cord-321401-w4ne60fn	92	23	)	)	-RRB-
cord-321401-w4ne60fn	92	24	 	 	_SP
cord-321401-w4ne60fn	92	25	T	t	NN
cord-321401-w4ne60fn	92	26	cells	cell	NNS
cord-321401-w4ne60fn	92	27	T	t	NN
cord-321401-w4ne60fn	92	28	cell	cell	NN
cord-321401-w4ne60fn	92	29	activators	activator	NNS
cord-321401-w4ne60fn	92	30	(	(	-LRB-
cord-321401-w4ne60fn	92	31	anti	anti	JJ
cord-321401-w4ne60fn	92	32	-	-	JJ
cord-321401-w4ne60fn	92	33	CD3	cd3	JJ
cord-321401-w4ne60fn	92	34	/	/	SYM
cord-321401-w4ne60fn	92	35	anti	anti	NNP
cord-321401-w4ne60fn	92	36	-	-	NNP
cord-321401-w4ne60fn	92	37	CD28	CD28	NNP
cord-321401-w4ne60fn	92	38	;	;	:
cord-321401-w4ne60fn	92	39	PHA	PHA	NNP
cord-321401-w4ne60fn	92	40	;	;	:
cord-321401-w4ne60fn	92	41	PMA	PMA	NNP
cord-321401-w4ne60fn	92	42	/	/	SYM
cord-321401-w4ne60fn	92	43	ionomycin	ionomycin	NNP
cord-321401-w4ne60fn	92	44	)	)	-RRB-
cord-321401-w4ne60fn	93	1	other	other	JJ
cord-321401-w4ne60fn	93	2	hand	hand	NN
cord-321401-w4ne60fn	93	3	,	,	,
cord-321401-w4ne60fn	93	4	in	in	IN
cord-321401-w4ne60fn	93	5	the	the	DT
cord-321401-w4ne60fn	93	6	bronchial	bronchial	JJ
cord-321401-w4ne60fn	93	7	cell	cell	NN
cord-321401-w4ne60fn	93	8	line	line	NN
cord-321401-w4ne60fn	93	9	BEAS-2B	BEAS-2B	NNP
cord-321401-w4ne60fn	93	10	expression	expression	NN
cord-321401-w4ne60fn	93	11	of	of	IN
cord-321401-w4ne60fn	93	12	VDR	VDR	NNP
cord-321401-w4ne60fn	93	13	was	be	VBD
cord-321401-w4ne60fn	93	14	decreased	decrease	VBN
cord-321401-w4ne60fn	93	15	after	after	IN
cord-321401-w4ne60fn	93	16	infection	infection	NN
cord-321401-w4ne60fn	93	17	with	with	IN
cord-321401-w4ne60fn	93	18	respiratory	respiratory	JJ
cord-321401-w4ne60fn	93	19	viruses	virus	NNS
cord-321401-w4ne60fn	93	20	such	such	JJ
cord-321401-w4ne60fn	93	21	as	as	IN
cord-321401-w4ne60fn	93	22	human	human	JJ
cord-321401-w4ne60fn	93	23	rhinovirus	rhinovirus	NN
cord-321401-w4ne60fn	93	24	(	(	-LRB-
cord-321401-w4ne60fn	93	25	HRV	HRV	NNP
cord-321401-w4ne60fn	93	26	)	)	-RRB-
cord-321401-w4ne60fn	93	27	and	and	CC
cord-321401-w4ne60fn	93	28	respiratory	respiratory	JJ
cord-321401-w4ne60fn	93	29	syncytial	syncytial	JJ
cord-321401-w4ne60fn	93	30	virus	virus	NN
cord-321401-w4ne60fn	93	31	(	(	-LRB-
cord-321401-w4ne60fn	93	32	RSV	RSV	NNP
cord-321401-w4ne60fn	93	33	)	)	-RRB-
cord-321401-w4ne60fn	93	34	(	(	-LRB-
cord-321401-w4ne60fn	93	35	58	58	CD
cord-321401-w4ne60fn	93	36	)	)	-RRB-
cord-321401-w4ne60fn	93	37	.	.	.
cord-321401-w4ne60fn	94	1	Collectively	collectively	RB
cord-321401-w4ne60fn	94	2	,	,	,
cord-321401-w4ne60fn	94	3	these	these	DT
cord-321401-w4ne60fn	94	4	studies	study	NNS
cord-321401-w4ne60fn	94	5	have	have	VBP
cord-321401-w4ne60fn	94	6	shown	show	VBN
cord-321401-w4ne60fn	94	7	in	in	IN
cord-321401-w4ne60fn	94	8	airway	airway	NN
cord-321401-w4ne60fn	94	9	epithelial	epithelial	JJ
cord-321401-w4ne60fn	94	10	cells	cell	NNS
cord-321401-w4ne60fn	94	11	that	that	WDT
cord-321401-w4ne60fn	94	12	respiratory	respiratory	JJ
cord-321401-w4ne60fn	94	13	viral	viral	JJ
cord-321401-w4ne60fn	94	14	-	-	HYPH
cord-321401-w4ne60fn	94	15	and	and	CC
cord-321401-w4ne60fn	94	16	bacterial	bacterial	JJ
cord-321401-w4ne60fn	94	17	infections	infection	NNS
cord-321401-w4ne60fn	94	18	can	can	MD
cord-321401-w4ne60fn	94	19	either	either	CC
cord-321401-w4ne60fn	94	20	promote	promote	VB
cord-321401-w4ne60fn	94	21	or	or	CC
cord-321401-w4ne60fn	94	22	impair	impair	VB
cord-321401-w4ne60fn	94	23	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	94	24	)	)	-RRB-
cord-321401-w4ne60fn	94	25	2	2	CD
cord-321401-w4ne60fn	94	26	D	d	NN
cord-321401-w4ne60fn	94	27	synthesis	synthesis	NN
cord-321401-w4ne60fn	94	28	and	and	CC
cord-321401-w4ne60fn	94	29	responses	response	NNS
cord-321401-w4ne60fn	94	30	.	.	.
cord-321401-w4ne60fn	95	1	A	a	DT
cord-321401-w4ne60fn	95	2	local	local	JJ
cord-321401-w4ne60fn	95	3	airway	airway	NN
cord-321401-w4ne60fn	95	4	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	95	5	milieu	milieu	NN
cord-321401-w4ne60fn	95	6	can	can	MD
cord-321401-w4ne60fn	95	7	also	also	RB
cord-321401-w4ne60fn	95	8	exert	exert	VB
cord-321401-w4ne60fn	95	9	differential	differential	JJ
cord-321401-w4ne60fn	95	10	effects	effect	NNS
cord-321401-w4ne60fn	95	11	on	on	IN
cord-321401-w4ne60fn	95	12	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	95	13	)	)	-RRB-
cord-321401-w4ne60fn	95	14	2	2	CD
cord-321401-w4ne60fn	95	15	D	d	NN
cord-321401-w4ne60fn	95	16	synthesis	synthesis	NN
cord-321401-w4ne60fn	95	17	and	and	CC
cord-321401-w4ne60fn	95	18	signaling	signaling	NN
cord-321401-w4ne60fn	95	19	,	,	,
cord-321401-w4ne60fn	95	20	dependent	dependent	JJ
cord-321401-w4ne60fn	95	21	on	on	IN
cord-321401-w4ne60fn	95	22	the	the	DT
cord-321401-w4ne60fn	95	23	type	type	NN
cord-321401-w4ne60fn	95	24	of	of	IN
cord-321401-w4ne60fn	95	25	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	95	26	mediators	mediator	NNS
cord-321401-w4ne60fn	95	27	that	that	WDT
cord-321401-w4ne60fn	95	28	are	be	VBP
cord-321401-w4ne60fn	95	29	predominantly	predominantly	RB
cord-321401-w4ne60fn	95	30	present	present	JJ
cord-321401-w4ne60fn	95	31	.	.	.
cord-321401-w4ne60fn	96	1	We	-PRON-	PRP
cord-321401-w4ne60fn	96	2	have	have	VBP
cord-321401-w4ne60fn	96	3	shown	show	VBN
cord-321401-w4ne60fn	96	4	in	in	IN
cord-321401-w4ne60fn	96	5	differentiated	differentiated	JJ
cord-321401-w4ne60fn	96	6	primary	primary	JJ
cord-321401-w4ne60fn	96	7	airway	airway	NN
cord-321401-w4ne60fn	96	8	epithelial	epithelial	JJ
cord-321401-w4ne60fn	96	9	cells	cell	NNS
cord-321401-w4ne60fn	96	10	that	that	WDT
cord-321401-w4ne60fn	96	11	Th2	th2	CD
cord-321401-w4ne60fn	96	12	cytokines	cytokine	NNS
cord-321401-w4ne60fn	96	13	such	such	JJ
cord-321401-w4ne60fn	96	14	as	as	IN
cord-321401-w4ne60fn	96	15	IL-4	IL-4	NNP
cord-321401-w4ne60fn	96	16	and	and	CC
cord-321401-w4ne60fn	96	17	IL-13	IL-13	NNP
cord-321401-w4ne60fn	96	18	,	,	,
cord-321401-w4ne60fn	96	19	enhance	enhance	VB
cord-321401-w4ne60fn	96	20	expression	expression	NN
cord-321401-w4ne60fn	96	21	of	of	IN
cord-321401-w4ne60fn	96	22	CYP27B1	cyp27b1	NN
cord-321401-w4ne60fn	96	23	and	and	CC
cord-321401-w4ne60fn	96	24	expression	expression	NN
cord-321401-w4ne60fn	96	25	of	of	IN
cord-321401-w4ne60fn	96	26	hCAP18	hCAP18	NNP
cord-321401-w4ne60fn	96	27	/	/	SYM
cord-321401-w4ne60fn	96	28	LL-37	LL-37	NNP
cord-321401-w4ne60fn	96	29	upon	upon	IN
cord-321401-w4ne60fn	96	30	25(OH)D3	25(oh)d3	CD
cord-321401-w4ne60fn	96	31	treatment	treatment	NN
cord-321401-w4ne60fn	96	32	,	,	,
cord-321401-w4ne60fn	96	33	which	which	WDT
cord-321401-w4ne60fn	96	34	suggests	suggest	VBZ
cord-321401-w4ne60fn	96	35	that	that	IN
cord-321401-w4ne60fn	96	36	a	a	DT
cord-321401-w4ne60fn	96	37	Th2-inflammatory	Th2-inflammatory	NNP
cord-321401-w4ne60fn	96	38	environment	environment	NN
cord-321401-w4ne60fn	96	39	,	,	,
cord-321401-w4ne60fn	96	40	as	as	IN
cord-321401-w4ne60fn	96	41	found	find	VBN
cord-321401-w4ne60fn	96	42	in	in	IN
cord-321401-w4ne60fn	96	43	allergic	allergic	JJ
cord-321401-w4ne60fn	96	44	airway	airway	NN
cord-321401-w4ne60fn	96	45	inflammation	inflammation	NN
cord-321401-w4ne60fn	96	46	,	,	,
cord-321401-w4ne60fn	96	47	increases	increase	VBZ
cord-321401-w4ne60fn	96	48	the	the	DT
cord-321401-w4ne60fn	96	49	conversion	conversion	NN
cord-321401-w4ne60fn	96	50	of	of	IN
cord-321401-w4ne60fn	96	51	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	96	52	into	into	IN
cord-321401-w4ne60fn	96	53	the	the	DT
cord-321401-w4ne60fn	96	54	active	active	JJ
cord-321401-w4ne60fn	96	55	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	96	56	)	)	-RRB-
cord-321401-w4ne60fn	96	57	2	2	CD
cord-321401-w4ne60fn	96	58	D	d	NN
cord-321401-w4ne60fn	96	59	(	(	-LRB-
cord-321401-w4ne60fn	96	60	83	83	CD
cord-321401-w4ne60fn	96	61	,	,	,
cord-321401-w4ne60fn	96	62	85	85	CD
cord-321401-w4ne60fn	96	63	)	)	-RRB-
cord-321401-w4ne60fn	96	64	.	.	.
cord-321401-w4ne60fn	97	1	The	the	DT
cord-321401-w4ne60fn	97	2	observation	observation	NN
cord-321401-w4ne60fn	97	3	that	that	IN
cord-321401-w4ne60fn	97	4	levels	level	NNS
cord-321401-w4ne60fn	97	5	of	of	IN
cord-321401-w4ne60fn	97	6	both	both	DT
cord-321401-w4ne60fn	97	7	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	97	8	)	)	-RRB-
cord-321401-w4ne60fn	97	9	2	2	CD
cord-321401-w4ne60fn	97	10	D	d	NN
cord-321401-w4ne60fn	97	11	and	and	CC
cord-321401-w4ne60fn	97	12	hCAP18	hCAP18	NNP
cord-321401-w4ne60fn	97	13	/	/	SYM
cord-321401-w4ne60fn	97	14	LL-37	LL-37	NNP
cord-321401-w4ne60fn	97	15	were	be	VBD
cord-321401-w4ne60fn	97	16	increased	increase	VBN
cord-321401-w4ne60fn	97	17	in	in	IN
cord-321401-w4ne60fn	97	18	bronchoalveolar	bronchoalveolar	NNP
cord-321401-w4ne60fn	97	19	lavage	lavage	NNP
cord-321401-w4ne60fn	97	20	(	(	-LRB-
cord-321401-w4ne60fn	97	21	BAL	BAL	NNP
cord-321401-w4ne60fn	97	22	)	)	-RRB-
cord-321401-w4ne60fn	97	23	after	after	IN
cord-321401-w4ne60fn	97	24	allergen	allergen	NN
cord-321401-w4ne60fn	97	25	challenge	challenge	NN
cord-321401-w4ne60fn	97	26	is	be	VBZ
cord-321401-w4ne60fn	97	27	in	in	IN
cord-321401-w4ne60fn	97	28	line	line	NN
cord-321401-w4ne60fn	97	29	with	with	IN
cord-321401-w4ne60fn	97	30	this	this	DT
cord-321401-w4ne60fn	97	31	proposed	propose	VBN
cord-321401-w4ne60fn	97	32	mechanism	mechanism	NN
cord-321401-w4ne60fn	97	33	(	(	-LRB-
cord-321401-w4ne60fn	97	34	86	86	CD
cord-321401-w4ne60fn	97	35	)	)	-RRB-
cord-321401-w4ne60fn	97	36	.	.	.
cord-321401-w4ne60fn	98	1	This	this	DT
cord-321401-w4ne60fn	98	2	effect	effect	NN
cord-321401-w4ne60fn	98	3	of	of	IN
cord-321401-w4ne60fn	98	4	Th2	Th2	NNP
cord-321401-w4ne60fn	98	5	cytokines	cytokine	NNS
cord-321401-w4ne60fn	98	6	was	be	VBD
cord-321401-w4ne60fn	98	7	in	in	IN
cord-321401-w4ne60fn	98	8	contrast	contrast	NN
cord-321401-w4ne60fn	98	9	to	to	IN
cord-321401-w4ne60fn	98	10	the	the	DT
cord-321401-w4ne60fn	98	11	effects	effect	NNS
cord-321401-w4ne60fn	98	12	(	(	-LRB-
cord-321401-w4ne60fn	98	13	chronic	chronic	JJ
cord-321401-w4ne60fn	98	14	)	)	-RRB-
cord-321401-w4ne60fn	98	15	exposures	exposure	NNS
cord-321401-w4ne60fn	98	16	to	to	IN
cord-321401-w4ne60fn	98	17	the	the	DT
cord-321401-w4ne60fn	98	18	proinflammatory	proinflammatory	JJ
cord-321401-w4ne60fn	98	19	cytokines	cytokine	NNS
cord-321401-w4ne60fn	98	20	IL-1β	IL-1β	NNP
cord-321401-w4ne60fn	98	21	,	,	,
cord-321401-w4ne60fn	98	22	TNF	TNF	NNP
cord-321401-w4ne60fn	98	23	-	-	HYPH
cord-321401-w4ne60fn	98	24	α	α	NNP
cord-321401-w4ne60fn	98	25	and	and	CC
cord-321401-w4ne60fn	98	26	IL-17A	IL-17A	NNP
cord-321401-w4ne60fn	98	27	that	that	WDT
cord-321401-w4ne60fn	98	28	strongly	strongly	RB
cord-321401-w4ne60fn	98	29	increased	increase	VBD
cord-321401-w4ne60fn	98	30	the	the	DT
cord-321401-w4ne60fn	98	31	expression	expression	NN
cord-321401-w4ne60fn	98	32	of	of	IN
cord-321401-w4ne60fn	98	33	the	the	DT
cord-321401-w4ne60fn	98	34	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	98	35	-	-	:
cord-321401-w4ne60fn	98	36	and	and	CC
cord-321401-w4ne60fn	98	37	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	98	38	)	)	-RRB-
cord-321401-w4ne60fn	99	1	2	2	LS
cord-321401-w4ne60fn	99	2	D	d	NN
cord-321401-w4ne60fn	99	3	-	-	HYPH
cord-321401-w4ne60fn	99	4	degrading	degrade	VBG
cord-321401-w4ne60fn	99	5	CYP24A1	cyp24a1	NN
cord-321401-w4ne60fn	99	6	,	,	,
cord-321401-w4ne60fn	99	7	even	even	RB
cord-321401-w4ne60fn	99	8	in	in	IN
cord-321401-w4ne60fn	99	9	absence	absence	NN
cord-321401-w4ne60fn	99	10	of	of	IN
cord-321401-w4ne60fn	99	11	its	-PRON-	PRP$
cord-321401-w4ne60fn	99	12	inducer	inducer	NN
cord-321401-w4ne60fn	99	13	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	99	14	)	)	-RRB-
cord-321401-w4ne60fn	99	15	2	2	CD
cord-321401-w4ne60fn	99	16	D	d	NN
cord-321401-w4ne60fn	99	17	(	(	-LRB-
cord-321401-w4ne60fn	99	18	61	61	CD
cord-321401-w4ne60fn	99	19	)	)	-RRB-
cord-321401-w4ne60fn	99	20	.	.	.
cord-321401-w4ne60fn	100	1	Furthermore	furthermore	RB
cord-321401-w4ne60fn	100	2	,	,	,
cord-321401-w4ne60fn	100	3	shortterm	shortterm	JJ
cord-321401-w4ne60fn	100	4	exposures	exposure	NNS
cord-321401-w4ne60fn	100	5	to	to	IN
cord-321401-w4ne60fn	100	6	TGF	TGF	NNP
cord-321401-w4ne60fn	100	7	-	-	HYPH
cord-321401-w4ne60fn	100	8	β1	β1	NNP
cord-321401-w4ne60fn	100	9	,	,	,
cord-321401-w4ne60fn	100	10	a	a	DT
cord-321401-w4ne60fn	100	11	pleiotropic	pleiotropic	JJ
cord-321401-w4ne60fn	100	12	growth	growth	NN
cord-321401-w4ne60fn	100	13	factor	factor	NN
cord-321401-w4ne60fn	100	14	which	which	WDT
cord-321401-w4ne60fn	100	15	is	be	VBZ
cord-321401-w4ne60fn	100	16	elevated	elevate	VBN
cord-321401-w4ne60fn	100	17	in	in	IN
cord-321401-w4ne60fn	100	18	the	the	DT
cord-321401-w4ne60fn	100	19	lungs	lung	NNS
cord-321401-w4ne60fn	100	20	of	of	IN
cord-321401-w4ne60fn	100	21	COPD	COPD	NNP
cord-321401-w4ne60fn	100	22	,	,	,
cord-321401-w4ne60fn	100	23	CF	CF	NNP
cord-321401-w4ne60fn	100	24	and	and	CC
cord-321401-w4ne60fn	100	25	asthma	asthma	NN
cord-321401-w4ne60fn	100	26	patients	patient	NNS
cord-321401-w4ne60fn	100	27	,	,	,
cord-321401-w4ne60fn	100	28	also	also	RB
cord-321401-w4ne60fn	100	29	increases	increase	VBZ
cord-321401-w4ne60fn	100	30	the	the	DT
cord-321401-w4ne60fn	100	31	expression	expression	NN
cord-321401-w4ne60fn	100	32	of	of	IN
cord-321401-w4ne60fn	100	33	CYP24A1	CYP24A1	NNP
cord-321401-w4ne60fn	100	34	(	(	-LRB-
cord-321401-w4ne60fn	100	35	62	62	CD
cord-321401-w4ne60fn	100	36	)	)	-RRB-
cord-321401-w4ne60fn	100	37	.	.	.
cord-321401-w4ne60fn	101	1	As	as	IN
cord-321401-w4ne60fn	101	2	a	a	DT
cord-321401-w4ne60fn	101	3	consequence	consequence	NN
cord-321401-w4ne60fn	101	4	,	,	,
cord-321401-w4ne60fn	101	5	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	101	6	)	)	-RRB-
cord-321401-w4ne60fn	101	7	2	2	CD
cord-321401-w4ne60fn	101	8	D	d	NN
cord-321401-w4ne60fn	101	9	-	-	HYPH
cord-321401-w4ne60fn	101	10	mediated	mediate	VBN
cord-321401-w4ne60fn	101	11	expression	expression	NN
cord-321401-w4ne60fn	101	12	of	of	IN
cord-321401-w4ne60fn	101	13	the	the	DT
cord-321401-w4ne60fn	101	14	AMP	amp	NN
cord-321401-w4ne60fn	102	1	hCAP18	hCAP18	NNP
cord-321401-w4ne60fn	102	2	/	/	SYM
cord-321401-w4ne60fn	102	3	LL-37	LL-37	NNP
cord-321401-w4ne60fn	102	4	was	be	VBD
cord-321401-w4ne60fn	102	5	impaired	impair	VBN
cord-321401-w4ne60fn	102	6	,	,	,
cord-321401-w4ne60fn	102	7	which	which	WDT
cord-321401-w4ne60fn	102	8	was	be	VBD
cord-321401-w4ne60fn	102	9	likely	likely	RB
cord-321401-w4ne60fn	102	10	the	the	DT
cord-321401-w4ne60fn	102	11	result	result	NN
cord-321401-w4ne60fn	102	12	of	of	IN
cord-321401-w4ne60fn	102	13	the	the	DT
cord-321401-w4ne60fn	102	14	enhanced	enhanced	JJ
cord-321401-w4ne60fn	102	15	degradation	degradation	NN
cord-321401-w4ne60fn	102	16	of	of	IN
cord-321401-w4ne60fn	102	17	both	both	DT
cord-321401-w4ne60fn	102	18	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	102	19	and	and	CC
cord-321401-w4ne60fn	102	20	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	102	21	)	)	-RRB-
cord-321401-w4ne60fn	102	22	2	2	CD
cord-321401-w4ne60fn	102	23	D	d	NN
cord-321401-w4ne60fn	102	24	by	by	IN
cord-321401-w4ne60fn	102	25	this	this	DT
cord-321401-w4ne60fn	102	26	enzyme	enzyme	NN
cord-321401-w4ne60fn	102	27	(	(	-LRB-
cord-321401-w4ne60fn	102	28	61	61	CD
cord-321401-w4ne60fn	102	29	,	,	,
cord-321401-w4ne60fn	102	30	62	62	CD
cord-321401-w4ne60fn	102	31	)	)	-RRB-
cord-321401-w4ne60fn	102	32	.	.	.
cord-321401-w4ne60fn	103	1	In	in	IN
cord-321401-w4ne60fn	103	2	addition	addition	NN
cord-321401-w4ne60fn	103	3	to	to	IN
cord-321401-w4ne60fn	103	4	pathogens	pathogen	NNS
cord-321401-w4ne60fn	103	5	and	and	CC
cord-321401-w4ne60fn	103	6	cytokines	cytokine	NNS
cord-321401-w4ne60fn	103	7	,	,	,
cord-321401-w4ne60fn	103	8	exposure	exposure	NN
cord-321401-w4ne60fn	103	9	to	to	IN
cord-321401-w4ne60fn	103	10	inhaled	inhale	VBN
cord-321401-w4ne60fn	103	11	toxicants	toxicant	NNS
cord-321401-w4ne60fn	103	12	such	such	JJ
cord-321401-w4ne60fn	103	13	as	as	IN
cord-321401-w4ne60fn	103	14	cigarette	cigarette	NN
cord-321401-w4ne60fn	103	15	smoke	smoke	NN
cord-321401-w4ne60fn	103	16	(	(	-LRB-
cord-321401-w4ne60fn	103	17	CS	CS	NNP
cord-321401-w4ne60fn	103	18	)	)	-RRB-
cord-321401-w4ne60fn	103	19	and	and	CC
cord-321401-w4ne60fn	103	20	particulate	particulate	NN
cord-321401-w4ne60fn	103	21	matter	matter	NN
cord-321401-w4ne60fn	103	22	(	(	-LRB-
cord-321401-w4ne60fn	103	23	PM	pm	NN
cord-321401-w4ne60fn	103	24	)	)	-RRB-
cord-321401-w4ne60fn	103	25	may	may	MD
cord-321401-w4ne60fn	103	26	also	also	RB
cord-321401-w4ne60fn	103	27	alter	alter	VB
cord-321401-w4ne60fn	103	28	expression	expression	NN
cord-321401-w4ne60fn	103	29	or	or	CC
cord-321401-w4ne60fn	103	30	activity	activity	NN
cord-321401-w4ne60fn	103	31	of	of	IN
cord-321401-w4ne60fn	103	32	VDR	VDR	NNP
cord-321401-w4ne60fn	103	33	and	and	CC
cord-321401-w4ne60fn	103	34	CYP27B1	cyp27b1	NN
cord-321401-w4ne60fn	103	35	.	.	.
cord-321401-w4ne60fn	104	1	Studies	study	NNS
cord-321401-w4ne60fn	104	2	have	have	VBP
cord-321401-w4ne60fn	104	3	demonstrated	demonstrate	VBN
cord-321401-w4ne60fn	104	4	that	that	IN
cord-321401-w4ne60fn	104	5	cigarette	cigarette	NN
cord-321401-w4ne60fn	104	6	smoking	smoking	NN
cord-321401-w4ne60fn	104	7	or	or	CC
cord-321401-w4ne60fn	104	8	exposure	exposure	NN
cord-321401-w4ne60fn	104	9	to	to	IN
cord-321401-w4ne60fn	104	10	CS	CS	NNP
cord-321401-w4ne60fn	104	11	extract	extract	NN
cord-321401-w4ne60fn	104	12	(	(	-LRB-
cord-321401-w4ne60fn	104	13	CSE	CSE	NNP
cord-321401-w4ne60fn	104	14	)	)	-RRB-
cord-321401-w4ne60fn	104	15	decreases	decrease	VBZ
cord-321401-w4ne60fn	104	16	expression	expression	NN
cord-321401-w4ne60fn	104	17	of	of	IN
cord-321401-w4ne60fn	104	18	CYP27B1	cyp27b1	NN
cord-321401-w4ne60fn	104	19	and	and	CC
cord-321401-w4ne60fn	104	20	inhibited	inhibited	JJ
cord-321401-w4ne60fn	104	21	membrane	membrane	NN
cord-321401-w4ne60fn	104	22	bound	bind	VBN
cord-321401-w4ne60fn	104	23	(	(	-LRB-
cord-321401-w4ne60fn	104	24	m)VDR	m)vdr	NN
cord-321401-w4ne60fn	104	25	translocation	translocation	NN
cord-321401-w4ne60fn	104	26	to	to	IN
cord-321401-w4ne60fn	104	27	the	the	DT
cord-321401-w4ne60fn	104	28	cell	cell	NN
cord-321401-w4ne60fn	104	29	membrane	membrane	NN
cord-321401-w4ne60fn	104	30	in	in	IN
cord-321401-w4ne60fn	104	31	airway	airway	JJ
cord-321401-w4ne60fn	104	32	epithelial	epithelial	JJ
cord-321401-w4ne60fn	104	33	cells	cell	NNS
cord-321401-w4ne60fn	104	34	and	and	CC
cord-321401-w4ne60fn	104	35	A549	a549	JJ
cord-321401-w4ne60fn	104	36	cells	cell	NNS
cord-321401-w4ne60fn	104	37	(	(	-LRB-
cord-321401-w4ne60fn	104	38	an	an	DT
cord-321401-w4ne60fn	104	39	alveolar	alveolar	JJ
cord-321401-w4ne60fn	104	40	tumor	tumor	NN
cord-321401-w4ne60fn	104	41	cell	cell	NN
cord-321401-w4ne60fn	104	42	line	line	NN
cord-321401-w4ne60fn	104	43	)	)	-RRB-
cord-321401-w4ne60fn	104	44	,	,	,
cord-321401-w4ne60fn	104	45	respectively	respectively	RB
cord-321401-w4ne60fn	104	46	(	(	-LRB-
cord-321401-w4ne60fn	104	47	63	63	CD
cord-321401-w4ne60fn	104	48	,	,	,
cord-321401-w4ne60fn	104	49	64	64	CD
cord-321401-w4ne60fn	104	50	,	,	,
cord-321401-w4ne60fn	104	51	66	66	CD
cord-321401-w4ne60fn	104	52	)	)	-RRB-
cord-321401-w4ne60fn	104	53	.	.	.
cord-321401-w4ne60fn	105	1	This	this	DT
cord-321401-w4ne60fn	105	2	inhibition	inhibition	NN
cord-321401-w4ne60fn	105	3	reduces	reduce	VBZ
cord-321401-w4ne60fn	105	4	the	the	DT
cord-321401-w4ne60fn	105	5	conversion	conversion	NN
cord-321401-w4ne60fn	105	6	of	of	IN
cord-321401-w4ne60fn	105	7	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	105	8	to	to	IN
cord-321401-w4ne60fn	105	9	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	105	10	)	)	-RRB-
cord-321401-w4ne60fn	105	11	2	2	CD
cord-321401-w4ne60fn	105	12	D	d	NN
cord-321401-w4ne60fn	105	13	and	and	CC
cord-321401-w4ne60fn	105	14	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	105	15	)	)	-RRB-
cord-321401-w4ne60fn	105	16	2	2	CD
cord-321401-w4ne60fn	105	17	D	d	NN
cord-321401-w4ne60fn	105	18	-	-	HYPH
cord-321401-w4ne60fn	105	19	mediated	mediate	VBN
cord-321401-w4ne60fn	105	20	gene	gene	NN
cord-321401-w4ne60fn	105	21	expression	expression	NN
cord-321401-w4ne60fn	105	22	as	as	RB
cord-321401-w4ne60fn	105	23	well	well	RB
cord-321401-w4ne60fn	105	24	as	as	IN
cord-321401-w4ne60fn	105	25	nongenomic	nongenomic	JJ
cord-321401-w4ne60fn	105	26	actions	action	NNS
cord-321401-w4ne60fn	105	27	of	of	IN
cord-321401-w4ne60fn	105	28	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	105	29	)	)	-RRB-
cord-321401-w4ne60fn	105	30	2	2	CD
cord-321401-w4ne60fn	105	31	D	d	NN
cord-321401-w4ne60fn	105	32	-	-	HYPH
cord-321401-w4ne60fn	105	33	membrane	membrane	NN
cord-321401-w4ne60fn	105	34	associated	associate	VBN
cord-321401-w4ne60fn	105	35	,	,	,
cord-321401-w4ne60fn	105	36	rapid	rapid	JJ
cord-321401-w4ne60fn	105	37	response	response	NN
cord-321401-w4ne60fn	105	38	steroid	steroid	NN
cord-321401-w4ne60fn	105	39	-	-	HYPH
cord-321401-w4ne60fn	105	40	binding	bind	VBG
cord-321401-w4ne60fn	105	41	(	(	-LRB-
cord-321401-w4ne60fn	105	42	MARRS)-signaling	marrs)-signale	VBG
cord-321401-w4ne60fn	105	43	(	(	-LRB-
cord-321401-w4ne60fn	105	44	63	63	CD
cord-321401-w4ne60fn	105	45	,	,	,
cord-321401-w4ne60fn	105	46	64	64	CD
cord-321401-w4ne60fn	105	47	,	,	,
cord-321401-w4ne60fn	105	48	66	66	CD
cord-321401-w4ne60fn	105	49	)	)	-RRB-
cord-321401-w4ne60fn	105	50	.	.	.
cord-321401-w4ne60fn	106	1	This	this	DT
cord-321401-w4ne60fn	106	2	adverse	adverse	JJ
cord-321401-w4ne60fn	106	3	effect	effect	NN
cord-321401-w4ne60fn	106	4	of	of	IN
cord-321401-w4ne60fn	106	5	cigarette	cigarette	NN
cord-321401-w4ne60fn	106	6	smoking	smoking	NN
cord-321401-w4ne60fn	106	7	on	on	IN
cord-321401-w4ne60fn	106	8	the	the	DT
cord-321401-w4ne60fn	106	9	synthesis	synthesis	NN
cord-321401-w4ne60fn	106	10	and	and	CC
cord-321401-w4ne60fn	106	11	effects	effect	NNS
cord-321401-w4ne60fn	106	12	of	of	IN
cord-321401-w4ne60fn	106	13	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	106	14	)	)	-RRB-
cord-321401-w4ne60fn	106	15	2	2	CD
cord-321401-w4ne60fn	106	16	D	d	NN
cord-321401-w4ne60fn	106	17	in	in	IN
cord-321401-w4ne60fn	106	18	airway	airway	NN
cord-321401-w4ne60fn	106	19	epithelial	epithelial	JJ
cord-321401-w4ne60fn	106	20	cells	cell	NNS
cord-321401-w4ne60fn	106	21	was	be	VBD
cord-321401-w4ne60fn	106	22	recently	recently	RB
cord-321401-w4ne60fn	106	23	confirmed	confirm	VBN
cord-321401-w4ne60fn	106	24	in	in	IN
cord-321401-w4ne60fn	106	25	vivo	vivo	NN
cord-321401-w4ne60fn	106	26	by	by	IN
cord-321401-w4ne60fn	106	27	Vargas	Vargas	NNP
cord-321401-w4ne60fn	106	28	Buonfiglio	Buonfiglio	NNP
cord-321401-w4ne60fn	106	29	et	et	NNP
cord-321401-w4ne60fn	106	30	al	al	NNP
cord-321401-w4ne60fn	106	31	.	.	.
cord-321401-w4ne60fn	107	1	who	who	WP
cord-321401-w4ne60fn	107	2	demonstrated	demonstrate	VBD
cord-321401-w4ne60fn	107	3	that	that	IN
cord-321401-w4ne60fn	107	4	vitamin	vitamin	NN
cord-321401-w4ne60fn	107	5	D	D	NNP
cord-321401-w4ne60fn	107	6	supplementation	supplementation	NN
cord-321401-w4ne60fn	107	7	increased	increase	VBD
cord-321401-w4ne60fn	107	8	antimicrobial	antimicrobial	JJ
cord-321401-w4ne60fn	107	9	activity	activity	NN
cord-321401-w4ne60fn	107	10	in	in	IN
cord-321401-w4ne60fn	107	11	apical	apical	JJ
cord-321401-w4ne60fn	107	12	surface	surface	NN
cord-321401-w4ne60fn	107	13	liquid	liquid	NN
cord-321401-w4ne60fn	107	14	(	(	-LRB-
cord-321401-w4ne60fn	107	15	ASL	ASL	NNP
cord-321401-w4ne60fn	107	16	)	)	-RRB-
cord-321401-w4ne60fn	107	17	in	in	IN
cord-321401-w4ne60fn	107	18	the	the	DT
cord-321401-w4ne60fn	107	19	airway	airway	NN
cord-321401-w4ne60fn	107	20	of	of	IN
cord-321401-w4ne60fn	107	21	healthy	healthy	JJ
cord-321401-w4ne60fn	107	22	non	non	NNS
cord-321401-w4ne60fn	107	23	-	-	NNS
cord-321401-w4ne60fn	107	24	smokers	smoker	NNS
cord-321401-w4ne60fn	107	25	,	,	,
cord-321401-w4ne60fn	107	26	but	but	CC
cord-321401-w4ne60fn	107	27	not	not	RB
cord-321401-w4ne60fn	107	28	in	in	IN
cord-321401-w4ne60fn	107	29	smokers	smoker	NNS
cord-321401-w4ne60fn	107	30	(	(	-LRB-
cord-321401-w4ne60fn	107	31	64	64	CD
cord-321401-w4ne60fn	107	32	)	)	-RRB-
cord-321401-w4ne60fn	107	33	.	.	.
cord-321401-w4ne60fn	108	1	On	on	IN
cord-321401-w4ne60fn	108	2	the	the	DT
cord-321401-w4ne60fn	108	3	other	other	JJ
cord-321401-w4ne60fn	108	4	hand	hand	NN
cord-321401-w4ne60fn	108	5	,	,	,
cord-321401-w4ne60fn	108	6	exposure	exposure	NN
cord-321401-w4ne60fn	108	7	to	to	IN
cord-321401-w4ne60fn	108	8	PM	pm	NN
cord-321401-w4ne60fn	108	9	increases	increase	VBZ
cord-321401-w4ne60fn	108	10	the	the	DT
cord-321401-w4ne60fn	108	11	expression	expression	NN
cord-321401-w4ne60fn	108	12	of	of	IN
cord-321401-w4ne60fn	108	13	both	both	DT
cord-321401-w4ne60fn	108	14	CYP27B1	cyp27b1	NN
cord-321401-w4ne60fn	108	15	and	and	CC
cord-321401-w4ne60fn	108	16	VDR	VDR	NNP
cord-321401-w4ne60fn	108	17	in	in	IN
cord-321401-w4ne60fn	108	18	airway	airway	JJ
cord-321401-w4ne60fn	108	19	epithelial	epithelial	JJ
cord-321401-w4ne60fn	108	20	cells	cell	NNS
cord-321401-w4ne60fn	108	21	,	,	,
cord-321401-w4ne60fn	108	22	thereby	thereby	RB
cord-321401-w4ne60fn	108	23	possibly	possibly	RB
cord-321401-w4ne60fn	108	24	promoting	promote	VBG
cord-321401-w4ne60fn	108	25	the	the	DT
cord-321401-w4ne60fn	108	26	synthesis	synthesis	NN
cord-321401-w4ne60fn	108	27	and	and	CC
cord-321401-w4ne60fn	108	28	effects	effect	NNS
cord-321401-w4ne60fn	108	29	of	of	IN
cord-321401-w4ne60fn	108	30	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	108	31	)	)	-RRB-
cord-321401-w4ne60fn	108	32	2	2	CD
cord-321401-w4ne60fn	108	33	D	d	NN
cord-321401-w4ne60fn	108	34	(	(	-LRB-
cord-321401-w4ne60fn	108	35	59	59	CD
cord-321401-w4ne60fn	108	36	)	)	-RRB-
cord-321401-w4ne60fn	108	37	.	.	.
cord-321401-w4ne60fn	109	1	It	-PRON-	PRP
cord-321401-w4ne60fn	109	2	is	be	VBZ
cord-321401-w4ne60fn	109	3	however	however	RB
cord-321401-w4ne60fn	109	4	important	important	JJ
cord-321401-w4ne60fn	109	5	to	to	TO
cord-321401-w4ne60fn	109	6	consider	consider	VB
cord-321401-w4ne60fn	109	7	that	that	IN
cord-321401-w4ne60fn	109	8	several	several	JJ
cord-321401-w4ne60fn	109	9	retrospective	retrospective	JJ
cord-321401-w4ne60fn	109	10	and	and	CC
cord-321401-w4ne60fn	109	11	observational	observational	JJ
cord-321401-w4ne60fn	109	12	studies	study	NNS
cord-321401-w4ne60fn	109	13	have	have	VBP
cord-321401-w4ne60fn	109	14	demonstrated	demonstrate	VBN
cord-321401-w4ne60fn	109	15	that	that	IN
cord-321401-w4ne60fn	109	16	air	air	NN
cord-321401-w4ne60fn	109	17	pollution	pollution	NN
cord-321401-w4ne60fn	109	18	is	be	VBZ
cord-321401-w4ne60fn	109	19	an	an	DT
cord-321401-w4ne60fn	109	20	independent	independent	JJ
cord-321401-w4ne60fn	109	21	risk	risk	NN
cord-321401-w4ne60fn	109	22	factor	factor	NN
cord-321401-w4ne60fn	109	23	for	for	IN
cord-321401-w4ne60fn	109	24	developing	develop	VBG
cord-321401-w4ne60fn	109	25	vitamin	vitamin	NN
cord-321401-w4ne60fn	109	26	D	D	NNP
cord-321401-w4ne60fn	109	27	deficiency	deficiency	NN
cord-321401-w4ne60fn	109	28	(	(	-LRB-
cord-321401-w4ne60fn	109	29	87	87	CD
cord-321401-w4ne60fn	109	30	)	)	-RRB-
cord-321401-w4ne60fn	109	31	.	.	.
cord-321401-w4ne60fn	110	1	In	in	IN
cord-321401-w4ne60fn	110	2	conclusion	conclusion	NN
cord-321401-w4ne60fn	110	3	,	,	,
cord-321401-w4ne60fn	110	4	exposure	exposure	NN
cord-321401-w4ne60fn	110	5	to	to	IN
cord-321401-w4ne60fn	110	6	CS	CS	NNP
cord-321401-w4ne60fn	110	7	,	,	,
cord-321401-w4ne60fn	110	8	TGF	TGF	NNP
cord-321401-w4ne60fn	110	9	-	-	HYPH
cord-321401-w4ne60fn	110	10	β1	β1	NNP
cord-321401-w4ne60fn	110	11	and	and	CC
cord-321401-w4ne60fn	110	12	presence	presence	NN
cord-321401-w4ne60fn	110	13	of	of	IN
cord-321401-w4ne60fn	110	14	a	a	DT
cord-321401-w4ne60fn	110	15	proinflammatory	proinflammatory	JJ
cord-321401-w4ne60fn	110	16	milieu	milieu	NN
cord-321401-w4ne60fn	110	17	appeared	appear	VBD
cord-321401-w4ne60fn	110	18	to	to	IN
cord-321401-w4ne60fn	110	19	most	most	RBS
cord-321401-w4ne60fn	110	20	strongly	strongly	RB
cord-321401-w4ne60fn	110	21	decrease	decrease	VB
cord-321401-w4ne60fn	110	22	local	local	JJ
cord-321401-w4ne60fn	110	23	presence	presence	NN
cord-321401-w4ne60fn	110	24	and	and	CC
cord-321401-w4ne60fn	110	25	signaling	signaling	NN
cord-321401-w4ne60fn	110	26	of	of	IN
cord-321401-w4ne60fn	110	27	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	110	28	)	)	-RRB-
cord-321401-w4ne60fn	111	1	2	2	LS
cord-321401-w4ne60fn	111	2	D	d	NN
cord-321401-w4ne60fn	111	3	in	in	IN
cord-321401-w4ne60fn	111	4	airway	airway	NN
cord-321401-w4ne60fn	111	5	epithelial	epithelial	JJ
cord-321401-w4ne60fn	111	6	cells	cell	NNS
cord-321401-w4ne60fn	111	7	.	.	.
cord-321401-w4ne60fn	112	1	IgM	IgM	NNP
cord-321401-w4ne60fn	112	2	/	/	SYM
cord-321401-w4ne60fn	112	3	anti	anti	JJ
cord-321401-w4ne60fn	112	4	-	-	NNP
cord-321401-w4ne60fn	112	5	CD40	CD40	NNP
cord-321401-w4ne60fn	112	6	/	/	SYM
cord-321401-w4ne60fn	112	7	IL-21	IL-21	NNP
cord-321401-w4ne60fn	112	8	)	)	-RRB-
cord-321401-w4ne60fn	112	9	CYP27B1	cyp27b1	NN
cord-321401-w4ne60fn	112	10	↑	↑	NN
cord-321401-w4ne60fn	112	11	VDR	VDR	NNP
cord-321401-w4ne60fn	112	12	↑(79	↑(79	CD
cord-321401-w4ne60fn	112	13	)	)	-RRB-
cord-321401-w4ne60fn	113	1	Whereas	whereas	IN
cord-321401-w4ne60fn	113	2	,	,	,
cord-321401-w4ne60fn	113	3	various	various	JJ
cord-321401-w4ne60fn	113	4	studies	study	NNS
cord-321401-w4ne60fn	113	5	show	show	VBP
cord-321401-w4ne60fn	113	6	that	that	IN
cord-321401-w4ne60fn	113	7	exposure	exposure	NN
cord-321401-w4ne60fn	113	8	to	to	IN
cord-321401-w4ne60fn	113	9	proinflammatory	proinflammatory	JJ
cord-321401-w4ne60fn	113	10	stimuli	stimulus	NNS
cord-321401-w4ne60fn	113	11	most	most	RBS
cord-321401-w4ne60fn	113	12	likely	likely	RB
cord-321401-w4ne60fn	113	13	affects	affect	VBZ
cord-321401-w4ne60fn	113	14	local	local	JJ
cord-321401-w4ne60fn	113	15	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	113	16	and	and	CC
cord-321401-w4ne60fn	113	17	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	113	18	)	)	-RRB-
cord-321401-w4ne60fn	113	19	2	2	CD
cord-321401-w4ne60fn	113	20	Dlevels	Dlevels	NNPS
cord-321401-w4ne60fn	113	21	and	and	CC
cord-321401-w4ne60fn	113	22	reduces	reduce	VBZ
cord-321401-w4ne60fn	113	23	the	the	DT
cord-321401-w4ne60fn	113	24	effects	effect	NNS
cord-321401-w4ne60fn	113	25	of	of	IN
cord-321401-w4ne60fn	113	26	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	113	27	and	and	CC
cord-321401-w4ne60fn	113	28	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	113	29	)	)	-RRB-
cord-321401-w4ne60fn	113	30	2	2	CD
cord-321401-w4ne60fn	113	31	D	d	NN
cord-321401-w4ne60fn	113	32	in	in	IN
cord-321401-w4ne60fn	113	33	(	(	-LRB-
cord-321401-w4ne60fn	113	34	airway	airway	NN
cord-321401-w4ne60fn	113	35	)	)	-RRB-
cord-321401-w4ne60fn	113	36	epithelial	epithelial	JJ
cord-321401-w4ne60fn	113	37	cells	cell	NNS
cord-321401-w4ne60fn	113	38	,	,	,
cord-321401-w4ne60fn	113	39	the	the	DT
cord-321401-w4ne60fn	113	40	opposite	opposite	NN
cord-321401-w4ne60fn	113	41	appears	appear	VBZ
cord-321401-w4ne60fn	113	42	to	to	TO
cord-321401-w4ne60fn	113	43	be	be	VB
cord-321401-w4ne60fn	113	44	the	the	DT
cord-321401-w4ne60fn	113	45	case	case	NN
cord-321401-w4ne60fn	113	46	for	for	IN
cord-321401-w4ne60fn	113	47	immune	immune	JJ
cord-321401-w4ne60fn	113	48	cells	cell	NNS
cord-321401-w4ne60fn	113	49	.	.	.
cord-321401-w4ne60fn	114	1	In	in	IN
cord-321401-w4ne60fn	114	2	monocytes	monocyte	NNS
cord-321401-w4ne60fn	114	3	,	,	,
cord-321401-w4ne60fn	114	4	macrophages	macrophage	NNS
cord-321401-w4ne60fn	114	5	and	and	CC
cord-321401-w4ne60fn	114	6	neutrophils	neutrophil	NNS
cord-321401-w4ne60fn	114	7	,	,	,
cord-321401-w4ne60fn	114	8	effects	effect	NNS
cord-321401-w4ne60fn	114	9	on	on	IN
cord-321401-w4ne60fn	114	10	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	114	11	)	)	-RRB-
cord-321401-w4ne60fn	114	12	2	2	CD
cord-321401-w4ne60fn	114	13	D	d	NN
cord-321401-w4ne60fn	114	14	synthesis	synthesis	NN
cord-321401-w4ne60fn	114	15	and	and	CC
cord-321401-w4ne60fn	114	16	antimicrobial	antimicrobial	JJ
cord-321401-w4ne60fn	114	17	responses	response	NNS
cord-321401-w4ne60fn	114	18	upon	upon	IN
cord-321401-w4ne60fn	114	19	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	114	20	treatment	treatment	NN
cord-321401-w4ne60fn	114	21	were	be	VBD
cord-321401-w4ne60fn	114	22	generally	generally	RB
cord-321401-w4ne60fn	114	23	enhanced	enhance	VBN
cord-321401-w4ne60fn	114	24	by	by	IN
cord-321401-w4ne60fn	114	25	these	these	DT
cord-321401-w4ne60fn	114	26	proinflammatory	proinflammatory	JJ
cord-321401-w4ne60fn	114	27	stimuli	stimulus	NNS
cord-321401-w4ne60fn	114	28	as	as	IN
cord-321401-w4ne60fn	114	29	illustrated	illustrate	VBN
cord-321401-w4ne60fn	114	30	by	by	IN
cord-321401-w4ne60fn	114	31	increased	increase	VBN
cord-321401-w4ne60fn	114	32	expression	expression	NN
cord-321401-w4ne60fn	114	33	of	of	IN
cord-321401-w4ne60fn	114	34	both	both	CC
cord-321401-w4ne60fn	114	35	VDR	VDR	NNP
cord-321401-w4ne60fn	114	36	and	and	CC
cord-321401-w4ne60fn	114	37	CYP27B1	cyp27b1	NN
cord-321401-w4ne60fn	114	38	(	(	-LRB-
cord-321401-w4ne60fn	114	39	39	39	CD
cord-321401-w4ne60fn	114	40	,	,	,
cord-321401-w4ne60fn	114	41	71	71	CD
cord-321401-w4ne60fn	114	42	,	,	,
cord-321401-w4ne60fn	114	43	(	(	-LRB-
cord-321401-w4ne60fn	114	44	74	74	CD
cord-321401-w4ne60fn	114	45	)	)	-RRB-
cord-321401-w4ne60fn	114	46	(	(	-LRB-
cord-321401-w4ne60fn	114	47	75	75	CD
cord-321401-w4ne60fn	114	48	)	)	-RRB-
cord-321401-w4ne60fn	114	49	(	(	-LRB-
cord-321401-w4ne60fn	114	50	76	76	CD
cord-321401-w4ne60fn	114	51	)	)	-RRB-
cord-321401-w4ne60fn	114	52	(	(	-LRB-
cord-321401-w4ne60fn	114	53	77	77	CD
cord-321401-w4ne60fn	114	54	)	)	-RRB-
cord-321401-w4ne60fn	114	55	.	.	.
cord-321401-w4ne60fn	115	1	It	-PRON-	PRP
cord-321401-w4ne60fn	115	2	is	be	VBZ
cord-321401-w4ne60fn	115	3	therefore	therefore	RB
cord-321401-w4ne60fn	115	4	tempting	tempt	VBG
cord-321401-w4ne60fn	115	5	to	to	TO
cord-321401-w4ne60fn	115	6	speculate	speculate	VB
cord-321401-w4ne60fn	115	7	that	that	IN
cord-321401-w4ne60fn	115	8	this	this	DT
cord-321401-w4ne60fn	115	9	apparent	apparent	JJ
cord-321401-w4ne60fn	115	10	increase	increase	NN
cord-321401-w4ne60fn	115	11	in	in	IN
cord-321401-w4ne60fn	115	12	antimicrobial	antimicrobial	JJ
cord-321401-w4ne60fn	115	13	responses	response	NNS
cord-321401-w4ne60fn	115	14	upon	upon	IN
cord-321401-w4ne60fn	115	15	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	115	16	treatment	treatment	NN
cord-321401-w4ne60fn	115	17	in	in	IN
cord-321401-w4ne60fn	115	18	immune	immune	JJ
cord-321401-w4ne60fn	115	19	cells	cell	NNS
cord-321401-w4ne60fn	115	20	in	in	IN
cord-321401-w4ne60fn	115	21	an	an	DT
cord-321401-w4ne60fn	115	22	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	115	23	environment	environment	NN
cord-321401-w4ne60fn	115	24	may	may	MD
cord-321401-w4ne60fn	115	25	serve	serve	VB
cord-321401-w4ne60fn	115	26	as	as	IN
cord-321401-w4ne60fn	115	27	a	a	DT
cord-321401-w4ne60fn	115	28	second	second	JJ
cord-321401-w4ne60fn	115	29	line	line	NN
cord-321401-w4ne60fn	115	30	of	of	IN
cord-321401-w4ne60fn	115	31	defense	defense	NN
cord-321401-w4ne60fn	115	32	and	and	CC
cord-321401-w4ne60fn	115	33	compensate	compensate	VB
cord-321401-w4ne60fn	115	34	for	for	IN
cord-321401-w4ne60fn	115	35	the	the	DT
cord-321401-w4ne60fn	115	36	enhanced	enhance	VBN
cord-321401-w4ne60fn	115	37	epithelial	epithelial	JJ
cord-321401-w4ne60fn	115	38	degradation	degradation	NN
cord-321401-w4ne60fn	115	39	of	of	IN
cord-321401-w4ne60fn	115	40	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	115	41	and	and	CC
cord-321401-w4ne60fn	115	42	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	115	43	)	)	-RRB-
cord-321401-w4ne60fn	115	44	2	2	CD
cord-321401-w4ne60fn	115	45	D	d	NN
cord-321401-w4ne60fn	115	46	during	during	IN
cord-321401-w4ne60fn	115	47	inflammation	inflammation	NN
cord-321401-w4ne60fn	115	48	.	.	.
cord-321401-w4ne60fn	116	1	Inhaled	inhale	VBN
cord-321401-w4ne60fn	116	2	toxicants	toxicant	NNS
cord-321401-w4ne60fn	116	3	may	may	MD
cord-321401-w4ne60fn	116	4	also	also	RB
cord-321401-w4ne60fn	116	5	affect	affect	VB
cord-321401-w4ne60fn	116	6	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	116	7	)	)	-RRB-
cord-321401-w4ne60fn	116	8	2	2	CD
cord-321401-w4ne60fn	116	9	D	d	NN
cord-321401-w4ne60fn	116	10	availability	availability	NN
cord-321401-w4ne60fn	116	11	and	and	CC
cord-321401-w4ne60fn	116	12	responsiveness	responsiveness	NN
cord-321401-w4ne60fn	116	13	of	of	IN
cord-321401-w4ne60fn	116	14	immune	immune	JJ
cord-321401-w4ne60fn	116	15	cells	cell	NNS
cord-321401-w4ne60fn	116	16	.	.	.
cord-321401-w4ne60fn	117	1	This	this	DT
cord-321401-w4ne60fn	117	2	is	be	VBZ
cord-321401-w4ne60fn	117	3	illustrated	illustrate	VBN
cord-321401-w4ne60fn	117	4	by	by	IN
cord-321401-w4ne60fn	117	5	two	two	CD
cord-321401-w4ne60fn	117	6	recent	recent	JJ
cord-321401-w4ne60fn	117	7	studies	study	NNS
cord-321401-w4ne60fn	117	8	studying	study	VBG
cord-321401-w4ne60fn	117	9	the	the	DT
cord-321401-w4ne60fn	117	10	effects	effect	NNS
cord-321401-w4ne60fn	117	11	of	of	IN
cord-321401-w4ne60fn	117	12	cigarette	cigarette	NN
cord-321401-w4ne60fn	117	13	smoke	smoke	NN
cord-321401-w4ne60fn	117	14	on	on	IN
cord-321401-w4ne60fn	117	15	the	the	DT
cord-321401-w4ne60fn	117	16	human	human	JJ
cord-321401-w4ne60fn	117	17	monocyte	monocyte	NNP
cord-321401-w4ne60fn	117	18	/	/	SYM
cord-321401-w4ne60fn	117	19	macrophage	macrophage	NN
cord-321401-w4ne60fn	117	20	-	-	HYPH
cord-321401-w4ne60fn	117	21	like	like	JJ
cord-321401-w4ne60fn	117	22	cell	cell	NN
cord-321401-w4ne60fn	117	23	line	line	NN
cord-321401-w4ne60fn	117	24	THP-1	THP-1	NNP
cord-321401-w4ne60fn	117	25	.	.	.
cord-321401-w4ne60fn	118	1	One	one	CD
cord-321401-w4ne60fn	118	2	study	study	NN
cord-321401-w4ne60fn	118	3	showed	show	VBD
cord-321401-w4ne60fn	118	4	that	that	IN
cord-321401-w4ne60fn	118	5	treatment	treatment	NN
cord-321401-w4ne60fn	118	6	with	with	IN
cord-321401-w4ne60fn	118	7	cigarette	cigarette	NN
cord-321401-w4ne60fn	118	8	smoke	smoke	NN
cord-321401-w4ne60fn	118	9	extract	extract	NN
cord-321401-w4ne60fn	118	10	(	(	-LRB-
cord-321401-w4ne60fn	118	11	CSE	CSE	NNP
cord-321401-w4ne60fn	118	12	)	)	-RRB-
cord-321401-w4ne60fn	118	13	increased	increase	VBD
cord-321401-w4ne60fn	118	14	the	the	DT
cord-321401-w4ne60fn	118	15	expression	expression	NN
cord-321401-w4ne60fn	118	16	of	of	IN
cord-321401-w4ne60fn	118	17	VDR	VDR	NNP
cord-321401-w4ne60fn	118	18	without	without	IN
cord-321401-w4ne60fn	118	19	enhancing	enhance	VBG
cord-321401-w4ne60fn	118	20	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	118	21	)	)	-RRB-
cord-321401-w4ne60fn	118	22	2	2	CD
cord-321401-w4ne60fn	118	23	D	d	NN
cord-321401-w4ne60fn	118	24	responses	response	NNS
cord-321401-w4ne60fn	118	25	(	(	-LRB-
cord-321401-w4ne60fn	118	26	72	72	CD
cord-321401-w4ne60fn	118	27	)	)	-RRB-
cord-321401-w4ne60fn	118	28	,	,	,
cord-321401-w4ne60fn	118	29	while	while	IN
cord-321401-w4ne60fn	118	30	the	the	DT
cord-321401-w4ne60fn	118	31	other	other	JJ
cord-321401-w4ne60fn	118	32	study	study	NN
cord-321401-w4ne60fn	118	33	-that	-that	NN
cord-321401-w4ne60fn	118	34	focused	focus	VBN
cord-321401-w4ne60fn	118	35	on	on	IN
cord-321401-w4ne60fn	118	36	the	the	DT
cord-321401-w4ne60fn	118	37	effects	effect	NNS
cord-321401-w4ne60fn	118	38	of	of	IN
cord-321401-w4ne60fn	118	39	Benzo[a]pyrene	Benzo[a]pyrene	NNP
cord-321401-w4ne60fn	118	40	(	(	-LRB-
cord-321401-w4ne60fn	118	41	BaP	bap	NN
cord-321401-w4ne60fn	118	42	)	)	-RRB-
cord-321401-w4ne60fn	118	43	(	(	-LRB-
cord-321401-w4ne60fn	118	44	a	a	DT
cord-321401-w4ne60fn	118	45	component	component	NN
cord-321401-w4ne60fn	118	46	produced	produce	VBN
cord-321401-w4ne60fn	118	47	by	by	IN
cord-321401-w4ne60fn	118	48	cigarette	cigarette	NN
cord-321401-w4ne60fn	118	49	combustion)-demonstrated	combustion)-demonstrated	NNP
cord-321401-w4ne60fn	118	50	that	that	IN
cord-321401-w4ne60fn	118	51	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	118	52	)	)	-RRB-
cord-321401-w4ne60fn	118	53	2	2	CD
cord-321401-w4ne60fn	119	1	Dmediated	Dmediated	NNP
cord-321401-w4ne60fn	119	2	CYP24A1	cyp24a1	JJ
cord-321401-w4ne60fn	119	3	expression	expression	NN
cord-321401-w4ne60fn	119	4	was	be	VBD
cord-321401-w4ne60fn	119	5	induced	induce	VBN
cord-321401-w4ne60fn	119	6	,	,	,
cord-321401-w4ne60fn	119	7	which	which	WDT
cord-321401-w4ne60fn	119	8	was	be	VBD
cord-321401-w4ne60fn	119	9	found	find	VBN
cord-321401-w4ne60fn	119	10	to	to	TO
cord-321401-w4ne60fn	119	11	further	further	RB
cord-321401-w4ne60fn	119	12	enhance	enhance	VB
cord-321401-w4ne60fn	119	13	degradation	degradation	NN
cord-321401-w4ne60fn	119	14	of	of	IN
cord-321401-w4ne60fn	119	15	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	119	16	)	)	-RRB-
cord-321401-w4ne60fn	120	1	2	2	LS
cord-321401-w4ne60fn	120	2	D	d	NN
cord-321401-w4ne60fn	120	3	(	(	-LRB-
cord-321401-w4ne60fn	120	4	73	73	CD
cord-321401-w4ne60fn	120	5	)	)	-RRB-
cord-321401-w4ne60fn	120	6	.	.	.
cord-321401-w4ne60fn	121	1	In	in	IN
cord-321401-w4ne60fn	121	2	summary	summary	NN
cord-321401-w4ne60fn	121	3	,	,	,
cord-321401-w4ne60fn	121	4	proinflammatory	proinflammatory	JJ
cord-321401-w4ne60fn	121	5	stimuli	stimulus	NNS
cord-321401-w4ne60fn	121	6	generally	generally	RB
cord-321401-w4ne60fn	121	7	increased	increase	VBD
cord-321401-w4ne60fn	121	8	the	the	DT
cord-321401-w4ne60fn	121	9	effect	effect	NN
cord-321401-w4ne60fn	121	10	of	of	IN
cord-321401-w4ne60fn	121	11	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	121	12	and	and	CC
cord-321401-w4ne60fn	121	13	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	121	14	)	)	-RRB-
cord-321401-w4ne60fn	122	1	2	2	LS
cord-321401-w4ne60fn	122	2	D	d	NN
cord-321401-w4ne60fn	122	3	on	on	IN
cord-321401-w4ne60fn	122	4	immune	immune	JJ
cord-321401-w4ne60fn	122	5	cells	cell	NNS
cord-321401-w4ne60fn	122	6	,	,	,
cord-321401-w4ne60fn	122	7	whereas	whereas	IN
cord-321401-w4ne60fn	122	8	more	more	JJR
cord-321401-w4ne60fn	122	9	studies	study	NNS
cord-321401-w4ne60fn	122	10	are	be	VBP
cord-321401-w4ne60fn	122	11	needed	need	VBN
cord-321401-w4ne60fn	122	12	to	to	TO
cord-321401-w4ne60fn	122	13	fully	fully	RB
cord-321401-w4ne60fn	122	14	determine	determine	VB
cord-321401-w4ne60fn	122	15	the	the	DT
cord-321401-w4ne60fn	122	16	impact	impact	NN
cord-321401-w4ne60fn	122	17	of	of	IN
cord-321401-w4ne60fn	122	18	exposure	exposure	NN
cord-321401-w4ne60fn	122	19	to	to	IN
cord-321401-w4ne60fn	122	20	cigarette	cigarette	NN
cord-321401-w4ne60fn	122	21	smoke	smoke	NN
cord-321401-w4ne60fn	122	22	and	and	CC
cord-321401-w4ne60fn	122	23	other	other	JJ
cord-321401-w4ne60fn	122	24	inhaled	inhale	VBN
cord-321401-w4ne60fn	122	25	toxicants	toxicant	NNS
cord-321401-w4ne60fn	122	26	.	.	.
cord-321401-w4ne60fn	123	1	Whereas	whereas	IN
cord-321401-w4ne60fn	123	2	,	,	,
cord-321401-w4ne60fn	123	3	these	these	DT
cord-321401-w4ne60fn	123	4	studies	study	NNS
cord-321401-w4ne60fn	123	5	provide	provide	VBP
cord-321401-w4ne60fn	123	6	evidence	evidence	NN
cord-321401-w4ne60fn	123	7	that	that	IN
cord-321401-w4ne60fn	123	8	inflammation	inflammation	NN
cord-321401-w4ne60fn	123	9	and	and	CC
cord-321401-w4ne60fn	123	10	inhaled	inhale	VBN
cord-321401-w4ne60fn	123	11	toxicants	toxicant	NNS
cord-321401-w4ne60fn	123	12	may	may	MD
cord-321401-w4ne60fn	123	13	affect	affect	VB
cord-321401-w4ne60fn	123	14	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	123	15	and	and	CC
cord-321401-w4ne60fn	123	16	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	123	17	)	)	-RRB-
cord-321401-w4ne60fn	123	18	2	2	CD
cord-321401-w4ne60fn	123	19	D	d	NN
cord-321401-w4ne60fn	123	20	metabolism	metabolism	NN
cord-321401-w4ne60fn	123	21	and	and	CC
cord-321401-w4ne60fn	123	22	responsiveness	responsiveness	NN
cord-321401-w4ne60fn	123	23	in	in	IN
cord-321401-w4ne60fn	123	24	epithelial	epithelial	JJ
cord-321401-w4ne60fn	123	25	cells	cell	NNS
cord-321401-w4ne60fn	123	26	and	and	CC
cord-321401-w4ne60fn	123	27	immune	immune	JJ
cord-321401-w4ne60fn	123	28	cells	cell	NNS
cord-321401-w4ne60fn	123	29	,	,	,
cord-321401-w4ne60fn	123	30	it	-PRON-	PRP
cord-321401-w4ne60fn	123	31	is	be	VBZ
cord-321401-w4ne60fn	123	32	not	not	RB
cord-321401-w4ne60fn	123	33	clear	clear	JJ
cord-321401-w4ne60fn	123	34	whether	whether	IN
cord-321401-w4ne60fn	123	35	this	this	DT
cord-321401-w4ne60fn	123	36	has	have	VBZ
cord-321401-w4ne60fn	123	37	an	an	DT
cord-321401-w4ne60fn	123	38	impact	impact	NN
cord-321401-w4ne60fn	123	39	on	on	IN
cord-321401-w4ne60fn	123	40	these	these	DT
cord-321401-w4ne60fn	123	41	events	event	NNS
cord-321401-w4ne60fn	123	42	in	in	IN
cord-321401-w4ne60fn	123	43	lung	lung	NN
cord-321401-w4ne60fn	123	44	tissue	tissue	NN
cord-321401-w4ne60fn	123	45	of	of	IN
cord-321401-w4ne60fn	123	46	patients	patient	NNS
cord-321401-w4ne60fn	123	47	with	with	IN
cord-321401-w4ne60fn	123	48	chronic	chronic	JJ
cord-321401-w4ne60fn	123	49	lung	lung	NN
cord-321401-w4ne60fn	123	50	diseases	disease	NNS
cord-321401-w4ne60fn	123	51	.	.	.
cord-321401-w4ne60fn	124	1	Although	although	IN
cord-321401-w4ne60fn	124	2	evidence	evidence	NN
cord-321401-w4ne60fn	124	3	is	be	VBZ
cord-321401-w4ne60fn	124	4	limited	limited	JJ
cord-321401-w4ne60fn	124	5	,	,	,
cord-321401-w4ne60fn	124	6	we	-PRON-	PRP
cord-321401-w4ne60fn	124	7	can	can	MD
cord-321401-w4ne60fn	124	8	speculate	speculate	VB
cord-321401-w4ne60fn	124	9	that	that	IN
cord-321401-w4ne60fn	124	10	levels	level	NNS
cord-321401-w4ne60fn	124	11	of	of	IN
cord-321401-w4ne60fn	124	12	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	124	13	)	)	-RRB-
cord-321401-w4ne60fn	124	14	2	2	CD
cord-321401-w4ne60fn	124	15	D	d	NN
cord-321401-w4ne60fn	124	16	and	and	CC
cord-321401-w4ne60fn	124	17	responses	response	NNS
cord-321401-w4ne60fn	124	18	are	be	VBP
cord-321401-w4ne60fn	124	19	also	also	RB
cord-321401-w4ne60fn	124	20	affected	affect	VBN
cord-321401-w4ne60fn	124	21	by	by	IN
cord-321401-w4ne60fn	124	22	disease	disease	NN
cord-321401-w4ne60fn	124	23	-	-	HYPH
cord-321401-w4ne60fn	124	24	associated	associate	VBN
cord-321401-w4ne60fn	124	25	factors	factor	NNS
cord-321401-w4ne60fn	124	26	in	in	IN
cord-321401-w4ne60fn	124	27	mesenchymal	mesenchymal	JJ
cord-321401-w4ne60fn	124	28	cells	cell	NNS
cord-321401-w4ne60fn	124	29	that	that	WDT
cord-321401-w4ne60fn	124	30	are	be	VBP
cord-321401-w4ne60fn	124	31	present	present	JJ
cord-321401-w4ne60fn	124	32	in	in	IN
cord-321401-w4ne60fn	124	33	the	the	DT
cord-321401-w4ne60fn	124	34	lung	lung	NN
cord-321401-w4ne60fn	124	35	mucosa	mucosa	RB
cord-321401-w4ne60fn	124	36	.	.	.
cord-321401-w4ne60fn	125	1	One	one	CD
cord-321401-w4ne60fn	125	2	study	study	NN
cord-321401-w4ne60fn	125	3	that	that	WDT
cord-321401-w4ne60fn	125	4	showed	show	VBD
cord-321401-w4ne60fn	125	5	in	in	IN
cord-321401-w4ne60fn	125	6	a	a	DT
cord-321401-w4ne60fn	125	7	bleomycin	bleomycin	NN
cord-321401-w4ne60fn	125	8	fibrosis	fibrosis	NN
cord-321401-w4ne60fn	125	9	model	model	NN
cord-321401-w4ne60fn	125	10	and	and	CC
cord-321401-w4ne60fn	125	11	in	in	IN
cord-321401-w4ne60fn	125	12	primary	primary	JJ
cord-321401-w4ne60fn	125	13	lung	lung	NN
cord-321401-w4ne60fn	125	14	mouse	mouse	NN
cord-321401-w4ne60fn	125	15	fibroblasts	fibroblast	NNS
cord-321401-w4ne60fn	125	16	that	that	IN
cord-321401-w4ne60fn	125	17	TGF	TGF	NNP
cord-321401-w4ne60fn	125	18	-	-	HYPH
cord-321401-w4ne60fn	125	19	β1	β1	NNP
cord-321401-w4ne60fn	125	20	reduced	reduce	VBN
cord-321401-w4ne60fn	125	21	expression	expression	NN
cord-321401-w4ne60fn	125	22	of	of	IN
cord-321401-w4ne60fn	125	23	the	the	DT
cord-321401-w4ne60fn	125	24	VDR	VDR	NNP
cord-321401-w4ne60fn	125	25	might	may	MD
cord-321401-w4ne60fn	125	26	support	support	VB
cord-321401-w4ne60fn	125	27	this	this	DT
cord-321401-w4ne60fn	125	28	assumption	assumption	NN
cord-321401-w4ne60fn	125	29	(	(	-LRB-
cord-321401-w4ne60fn	125	30	88	88	CD
cord-321401-w4ne60fn	125	31	)	)	-RRB-
cord-321401-w4ne60fn	125	32	.	.	.
cord-321401-w4ne60fn	126	1	It	-PRON-	PRP
cord-321401-w4ne60fn	126	2	is	be	VBZ
cord-321401-w4ne60fn	126	3	currently	currently	RB
cord-321401-w4ne60fn	126	4	insufficiently	insufficiently	RB
cord-321401-w4ne60fn	126	5	studied	study	VBN
cord-321401-w4ne60fn	126	6	whether	whether	IN
cord-321401-w4ne60fn	126	7	exposures	exposure	NNS
cord-321401-w4ne60fn	126	8	to	to	IN
cord-321401-w4ne60fn	126	9	disease	disease	NN
cord-321401-w4ne60fn	126	10	-	-	HYPH
cord-321401-w4ne60fn	126	11	associated	associate	VBN
cord-321401-w4ne60fn	126	12	factors	factor	NNS
cord-321401-w4ne60fn	126	13	promote	promote	VBP
cord-321401-w4ne60fn	126	14	or	or	CC
cord-321401-w4ne60fn	126	15	impair	impair	VB
cord-321401-w4ne60fn	126	16	levels	level	NNS
cord-321401-w4ne60fn	126	17	of	of	IN
cord-321401-w4ne60fn	126	18	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	126	19	)	)	-RRB-
cord-321401-w4ne60fn	126	20	2	2	CD
cord-321401-w4ne60fn	126	21	D	d	NN
cord-321401-w4ne60fn	126	22	and	and	CC
cord-321401-w4ne60fn	126	23	responses	response	NNS
cord-321401-w4ne60fn	126	24	in	in	IN
cord-321401-w4ne60fn	126	25	immune-	immune-	NNP
cord-321401-w4ne60fn	126	26	,	,	,
cord-321401-w4ne60fn	126	27	mesenchymal	mesenchymal	JJ
cord-321401-w4ne60fn	126	28	and	and	CC
cord-321401-w4ne60fn	126	29	epithelial	epithelial	JJ
cord-321401-w4ne60fn	126	30	cells	cell	NNS
cord-321401-w4ne60fn	126	31	combined	combine	VBN
cord-321401-w4ne60fn	126	32	to	to	TO
cord-321401-w4ne60fn	126	33	give	give	VB
cord-321401-w4ne60fn	126	34	a	a	DT
cord-321401-w4ne60fn	126	35	better	well	JJR
cord-321401-w4ne60fn	126	36	reflection	reflection	NN
cord-321401-w4ne60fn	126	37	of	of	IN
cord-321401-w4ne60fn	126	38	the	the	DT
cord-321401-w4ne60fn	126	39	in	in	IN
cord-321401-w4ne60fn	126	40	vivo	vivo	NN
cord-321401-w4ne60fn	126	41	situation	situation	NN
cord-321401-w4ne60fn	126	42	.	.	.
cord-321401-w4ne60fn	127	1	Interestingly	interestingly	RB
cord-321401-w4ne60fn	127	2	,	,	,
cord-321401-w4ne60fn	127	3	one	one	CD
cord-321401-w4ne60fn	127	4	study	study	NN
cord-321401-w4ne60fn	127	5	did	do	VBD
cord-321401-w4ne60fn	127	6	already	already	RB
cord-321401-w4ne60fn	127	7	show	show	VB
cord-321401-w4ne60fn	127	8	that	that	IN
cord-321401-w4ne60fn	127	9	nasal	nasal	NN
cord-321401-w4ne60fn	127	10	CYP27B1-and	cyp27b1-and	NN
cord-321401-w4ne60fn	127	11	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	127	12	)	)	-RRB-
cord-321401-w4ne60fn	127	13	2	2	CD
cord-321401-w4ne60fn	127	14	D	d	NN
cord-321401-w4ne60fn	127	15	-	-	HYPH
cord-321401-w4ne60fn	127	16	levels	level	NNS
cord-321401-w4ne60fn	127	17	are	be	VBP
cord-321401-w4ne60fn	127	18	both	both	DT
cord-321401-w4ne60fn	127	19	reduced	reduce	VBN
cord-321401-w4ne60fn	127	20	in	in	IN
cord-321401-w4ne60fn	127	21	chronic	chronic	JJ
cord-321401-w4ne60fn	127	22	rhinosinusitis	rhinosinusitis	NN
cord-321401-w4ne60fn	127	23	(	(	-LRB-
cord-321401-w4ne60fn	127	24	CRS	CRS	NNP
cord-321401-w4ne60fn	127	25	)	)	-RRB-
cord-321401-w4ne60fn	127	26	patients	patient	NNS
cord-321401-w4ne60fn	127	27	with	with	IN
cord-321401-w4ne60fn	127	28	nasal	nasal	JJ
cord-321401-w4ne60fn	127	29	polyps	polyp	NNS
cord-321401-w4ne60fn	127	30	as	as	IN
cord-321401-w4ne60fn	127	31	compared	compare	VBN
cord-321401-w4ne60fn	127	32	to	to	IN
cord-321401-w4ne60fn	127	33	CRS	CRS	NNP
cord-321401-w4ne60fn	127	34	-	-	HYPH
cord-321401-w4ne60fn	127	35	patients	patient	NNS
cord-321401-w4ne60fn	127	36	without	without	IN
cord-321401-w4ne60fn	127	37	nasal	nasal	NN
cord-321401-w4ne60fn	127	38	polyps	polyp	NNS
cord-321401-w4ne60fn	127	39	,	,	,
cord-321401-w4ne60fn	127	40	whereas	whereas	IN
cord-321401-w4ne60fn	127	41	no	no	DT
cord-321401-w4ne60fn	127	42	difference	difference	NN
cord-321401-w4ne60fn	127	43	was	be	VBD
cord-321401-w4ne60fn	127	44	found	find	VBN
cord-321401-w4ne60fn	127	45	in	in	IN
cord-321401-w4ne60fn	127	46	circulating	circulate	VBG
cord-321401-w4ne60fn	127	47	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	127	48	)	)	-RRB-
cord-321401-w4ne60fn	127	49	2	2	CD
cord-321401-w4ne60fn	127	50	Dlevels	Dlevels	NNPS
cord-321401-w4ne60fn	127	51	(	(	-LRB-
cord-321401-w4ne60fn	127	52	89	89	CD
cord-321401-w4ne60fn	127	53	)	)	-RRB-
cord-321401-w4ne60fn	127	54	.	.	.
cord-321401-w4ne60fn	128	1	Since	since	IN
cord-321401-w4ne60fn	128	2	most	most	JJS
cord-321401-w4ne60fn	128	3	other	other	JJ
cord-321401-w4ne60fn	128	4	studies	study	NNS
cord-321401-w4ne60fn	128	5	were	be	VBD
cord-321401-w4ne60fn	128	6	performed	perform	VBN
cord-321401-w4ne60fn	128	7	in	in	IN
cord-321401-w4ne60fn	128	8	vitro	vitro	FW
cord-321401-w4ne60fn	128	9	using	use	VBG
cord-321401-w4ne60fn	128	10	monocultures	monoculture	NNS
cord-321401-w4ne60fn	128	11	of	of	IN
cord-321401-w4ne60fn	128	12	epithelial	epithelial	JJ
cord-321401-w4ne60fn	128	13	cells	cell	NNS
cord-321401-w4ne60fn	128	14	or	or	CC
cord-321401-w4ne60fn	128	15	immune	immune	JJ
cord-321401-w4ne60fn	128	16	cells	cell	NNS
cord-321401-w4ne60fn	128	17	,	,	,
cord-321401-w4ne60fn	128	18	more	more	RBR
cord-321401-w4ne60fn	128	19	complex	complex	JJ
cord-321401-w4ne60fn	128	20	models	model	NNS
cord-321401-w4ne60fn	128	21	are	be	VBP
cord-321401-w4ne60fn	128	22	needed	need	VBN
cord-321401-w4ne60fn	128	23	to	to	TO
cord-321401-w4ne60fn	128	24	delineate	delineate	VB
cord-321401-w4ne60fn	128	25	this	this	DT
cord-321401-w4ne60fn	128	26	.	.	.
cord-321401-w4ne60fn	129	1	Therefore	therefore	RB
cord-321401-w4ne60fn	129	2	,	,	,
cord-321401-w4ne60fn	129	3	animal	animal	NN
cord-321401-w4ne60fn	129	4	models	model	NNS
cord-321401-w4ne60fn	129	5	or	or	CC
cord-321401-w4ne60fn	129	6	preferably	preferably	RB
cord-321401-w4ne60fn	129	7	more	more	RBR
cord-321401-w4ne60fn	129	8	complex	complex	JJ
cord-321401-w4ne60fn	129	9	animal	animal	NN
cord-321401-w4ne60fn	129	10	-	-	HYPH
cord-321401-w4ne60fn	129	11	free	free	JJ
cord-321401-w4ne60fn	129	12	cell	cell	NN
cord-321401-w4ne60fn	129	13	culture	culture	NN
cord-321401-w4ne60fn	129	14	models	model	NNS
cord-321401-w4ne60fn	129	15	using	use	VBG
cord-321401-w4ne60fn	129	16	co	co	NNS
cord-321401-w4ne60fn	129	17	-	-	NNS
cord-321401-w4ne60fn	129	18	cultures	culture	NNS
cord-321401-w4ne60fn	129	19	or	or	CC
cord-321401-w4ne60fn	129	20	organs	organ	NNS
cord-321401-w4ne60fn	129	21	-	-	HYPH
cord-321401-w4ne60fn	129	22	on	on	IN
cord-321401-w4ne60fn	129	23	-	-	HYPH
cord-321401-w4ne60fn	129	24	chips	chip	NNS
cord-321401-w4ne60fn	129	25	models	model	NNS
cord-321401-w4ne60fn	129	26	of	of	IN
cord-321401-w4ne60fn	129	27	primary	primary	JJ
cord-321401-w4ne60fn	129	28	fully	fully	RB
cord-321401-w4ne60fn	129	29	differentiated	differentiated	JJ
cord-321401-w4ne60fn	129	30	epithelial	epithelial	JJ
cord-321401-w4ne60fn	129	31	cells	cell	NNS
cord-321401-w4ne60fn	129	32	,	,	,
cord-321401-w4ne60fn	129	33	airway	airway	NN
cord-321401-w4ne60fn	129	34	-	-	HYPH
cord-321401-w4ne60fn	129	35	derived	derive	VBN
cord-321401-w4ne60fn	129	36	fibroblasts	fibroblast	NNS
cord-321401-w4ne60fn	129	37	or	or	CC
cord-321401-w4ne60fn	129	38	smooth	smooth	JJ
cord-321401-w4ne60fn	129	39	muscle	muscle	NN
cord-321401-w4ne60fn	129	40	cells	cell	NNS
cord-321401-w4ne60fn	129	41	and	and	CC
cord-321401-w4ne60fn	129	42	immune	immune	JJ
cord-321401-w4ne60fn	129	43	cells	cell	NNS
cord-321401-w4ne60fn	129	44	could	could	MD
cord-321401-w4ne60fn	129	45	be	be	VB
cord-321401-w4ne60fn	129	46	considered	consider	VBN
cord-321401-w4ne60fn	129	47	in	in	IN
cord-321401-w4ne60fn	129	48	future	future	JJ
cord-321401-w4ne60fn	129	49	studies	study	NNS
cord-321401-w4ne60fn	129	50	.	.	.
cord-321401-w4ne60fn	130	1	After	after	IN
cord-321401-w4ne60fn	130	2	discussing	discuss	VBG
cord-321401-w4ne60fn	130	3	altered	alter	VBN
cord-321401-w4ne60fn	130	4	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	130	5	and	and	CC
cord-321401-w4ne60fn	130	6	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	130	7	)	)	-RRB-
cord-321401-w4ne60fn	130	8	2	2	CD
cord-321401-w4ne60fn	130	9	D	d	NN
cord-321401-w4ne60fn	130	10	metabolism	metabolism	NN
cord-321401-w4ne60fn	130	11	and	and	CC
cord-321401-w4ne60fn	130	12	responsiveness	responsiveness	NN
cord-321401-w4ne60fn	130	13	in	in	IN
cord-321401-w4ne60fn	130	14	the	the	DT
cord-321401-w4ne60fn	130	15	inflamed	inflamed	JJ
cord-321401-w4ne60fn	130	16	airway	airway	NN
cord-321401-w4ne60fn	130	17	mucosa	mucosa	NN
cord-321401-w4ne60fn	130	18	,	,	,
cord-321401-w4ne60fn	130	19	it	-PRON-	PRP
cord-321401-w4ne60fn	130	20	is	be	VBZ
cord-321401-w4ne60fn	130	21	important	important	JJ
cord-321401-w4ne60fn	130	22	to	to	TO
cord-321401-w4ne60fn	130	23	consider	consider	VB
cord-321401-w4ne60fn	130	24	the	the	DT
cord-321401-w4ne60fn	130	25	possible	possible	JJ
cord-321401-w4ne60fn	130	26	consequences	consequence	NNS
cord-321401-w4ne60fn	130	27	of	of	IN
cord-321401-w4ne60fn	130	28	these	these	DT
cord-321401-w4ne60fn	130	29	inflammation	inflammation	NN
cord-321401-w4ne60fn	130	30	-	-	HYPH
cord-321401-w4ne60fn	130	31	induced	induce	VBN
cord-321401-w4ne60fn	130	32	changes	change	NNS
cord-321401-w4ne60fn	130	33	in	in	IN
cord-321401-w4ne60fn	130	34	the	the	DT
cord-321401-w4ne60fn	130	35	airway	airway	NN
cord-321401-w4ne60fn	130	36	mucosa	mucosa	NN
cord-321401-w4ne60fn	130	37	keeping	keep	VBG
cord-321401-w4ne60fn	130	38	in	in	IN
cord-321401-w4ne60fn	130	39	mind	mind	NN
cord-321401-w4ne60fn	130	40	the	the	DT
cord-321401-w4ne60fn	130	41	pleotropic	pleotropic	JJ
cord-321401-w4ne60fn	130	42	effects	effect	NNS
cord-321401-w4ne60fn	130	43	of	of	IN
cord-321401-w4ne60fn	130	44	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	130	45	)	)	-RRB-
cord-321401-w4ne60fn	130	46	2	2	CD
cord-321401-w4ne60fn	130	47	D	d	NN
cord-321401-w4ne60fn	130	48	that	that	WDT
cord-321401-w4ne60fn	130	49	were	be	VBD
cord-321401-w4ne60fn	130	50	introduced	introduce	VBN
cord-321401-w4ne60fn	130	51	earlier	early	RBR
cord-321401-w4ne60fn	130	52	.	.	.
cord-321401-w4ne60fn	131	1	In	in	IN
cord-321401-w4ne60fn	131	2	several	several	JJ
cord-321401-w4ne60fn	131	3	cells	cell	NNS
cord-321401-w4ne60fn	131	4	,	,	,
cord-321401-w4ne60fn	131	5	tissues	tissue	NNS
cord-321401-w4ne60fn	131	6	and	and	CC
cord-321401-w4ne60fn	131	7	organs	organ	NNS
cord-321401-w4ne60fn	131	8	,	,	,
cord-321401-w4ne60fn	131	9	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	131	10	)	)	-RRB-
cord-321401-w4ne60fn	131	11	2	2	CD
cord-321401-w4ne60fn	131	12	D	d	NN
cord-321401-w4ne60fn	131	13	regulates	regulate	VBZ
cord-321401-w4ne60fn	131	14	multiple	multiple	JJ
cord-321401-w4ne60fn	131	15	cellular	cellular	JJ
cord-321401-w4ne60fn	131	16	processes	process	NNS
cord-321401-w4ne60fn	131	17	that	that	WDT
cord-321401-w4ne60fn	131	18	affect	affect	VBP
cord-321401-w4ne60fn	131	19	normal	normal	JJ
cord-321401-w4ne60fn	131	20	and	and	CC
cord-321401-w4ne60fn	131	21	malignant	malignant	JJ
cord-321401-w4ne60fn	131	22	cell	cell	NN
cord-321401-w4ne60fn	131	23	growth	growth	NN
cord-321401-w4ne60fn	131	24	and	and	CC
cord-321401-w4ne60fn	131	25	differentiation	differentiation	NN
cord-321401-w4ne60fn	131	26	(	(	-LRB-
cord-321401-w4ne60fn	131	27	90	90	CD
cord-321401-w4ne60fn	131	28	,	,	,
cord-321401-w4ne60fn	131	29	91	91	CD
cord-321401-w4ne60fn	131	30	)	)	-RRB-
cord-321401-w4ne60fn	131	31	.	.	.
cord-321401-w4ne60fn	132	1	1,25(OH	1,25(oh	LS
cord-321401-w4ne60fn	132	2	)	)	-RRB-
cord-321401-w4ne60fn	132	3	2	2	CD
cord-321401-w4ne60fn	132	4	D	d	NN
cord-321401-w4ne60fn	132	5	displays	display	NNS
cord-321401-w4ne60fn	132	6	furthermore	furthermore	RB
cord-321401-w4ne60fn	132	7	protective	protective	JJ
cord-321401-w4ne60fn	132	8	effects	effect	NNS
cord-321401-w4ne60fn	132	9	on	on	IN
cord-321401-w4ne60fn	132	10	mucosal	mucosal	JJ
cord-321401-w4ne60fn	132	11	host	host	NN
cord-321401-w4ne60fn	132	12	defense	defense	NN
cord-321401-w4ne60fn	132	13	by	by	IN
cord-321401-w4ne60fn	132	14	maintaining	maintain	VBG
cord-321401-w4ne60fn	132	15	the	the	DT
cord-321401-w4ne60fn	132	16	integrity	integrity	NN
cord-321401-w4ne60fn	132	17	of	of	IN
cord-321401-w4ne60fn	132	18	the	the	DT
cord-321401-w4ne60fn	132	19	epithelial	epithelial	JJ
cord-321401-w4ne60fn	132	20	barrier	barrier	NN
cord-321401-w4ne60fn	132	21	,	,	,
cord-321401-w4ne60fn	132	22	inhibition	inhibition	NN
cord-321401-w4ne60fn	132	23	of	of	IN
cord-321401-w4ne60fn	132	24	epithelial	epithelial	NN
cord-321401-w4ne60fn	132	25	-	-	HYPH
cord-321401-w4ne60fn	132	26	to	to	IN
cord-321401-w4ne60fn	132	27	-	-	HYPH
cord-321401-w4ne60fn	132	28	mesenchymal	mesenchymal	JJ
cord-321401-w4ne60fn	132	29	transition	transition	NN
cord-321401-w4ne60fn	132	30	(	(	-LRB-
cord-321401-w4ne60fn	132	31	EMT	EMT	NNP
cord-321401-w4ne60fn	132	32	)	)	-RRB-
cord-321401-w4ne60fn	132	33	,	,	,
cord-321401-w4ne60fn	132	34	stimulating	stimulate	VBG
cord-321401-w4ne60fn	132	35	production	production	NN
cord-321401-w4ne60fn	132	36	of	of	IN
cord-321401-w4ne60fn	132	37	AMPs	amp	NNS
cord-321401-w4ne60fn	132	38	and	and	CC
cord-321401-w4ne60fn	132	39	modulating	modulate	VBG
cord-321401-w4ne60fn	132	40	both	both	DT
cord-321401-w4ne60fn	132	41	innate	innate	JJ
cord-321401-w4ne60fn	132	42	-	-	HYPH
cord-321401-w4ne60fn	132	43	and	and	CC
cord-321401-w4ne60fn	132	44	adaptive	adaptive	JJ
cord-321401-w4ne60fn	132	45	immune	immune	JJ
cord-321401-w4ne60fn	132	46	functions	function	NNS
cord-321401-w4ne60fn	132	47	(	(	-LRB-
cord-321401-w4ne60fn	132	48	7	7	CD
cord-321401-w4ne60fn	132	49	,	,	,
cord-321401-w4ne60fn	132	50	29	29	CD
cord-321401-w4ne60fn	132	51	,	,	,
cord-321401-w4ne60fn	132	52	92	92	CD
cord-321401-w4ne60fn	132	53	)	)	-RRB-
cord-321401-w4ne60fn	132	54	.	.	.
cord-321401-w4ne60fn	133	1	In	in	IN
cord-321401-w4ne60fn	133	2	addition	addition	NN
cord-321401-w4ne60fn	133	3	,	,	,
cord-321401-w4ne60fn	133	4	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	133	5	)	)	-RRB-
cord-321401-w4ne60fn	133	6	2	2	CD
cord-321401-w4ne60fn	133	7	D	D	NNP
cord-321401-w4ne60fn	133	8	maintains	maintain	VBZ
cord-321401-w4ne60fn	133	9	both	both	CC
cord-321401-w4ne60fn	133	10	energetic	energetic	JJ
cord-321401-w4ne60fn	133	11	and	and	CC
cord-321401-w4ne60fn	133	12	survival	survival	NN
cord-321401-w4ne60fn	133	13	homeostasis	homeostasis	NN
cord-321401-w4ne60fn	133	14	in	in	IN
cord-321401-w4ne60fn	133	15	the	the	DT
cord-321401-w4ne60fn	133	16	mucosal	mucosal	JJ
cord-321401-w4ne60fn	133	17	epithelium	epithelium	NN
cord-321401-w4ne60fn	133	18	through	through	IN
cord-321401-w4ne60fn	133	19	the	the	DT
cord-321401-w4ne60fn	133	20	modulation	modulation	NN
cord-321401-w4ne60fn	133	21	of	of	IN
cord-321401-w4ne60fn	133	22	stress	stress	NN
cord-321401-w4ne60fn	133	23	and	and	CC
cord-321401-w4ne60fn	133	24	damage	damage	NN
cord-321401-w4ne60fn	133	25	responses	response	NNS
cord-321401-w4ne60fn	133	26	,	,	,
cord-321401-w4ne60fn	133	27	including	include	VBG
cord-321401-w4ne60fn	133	28	clearance	clearance	NN
cord-321401-w4ne60fn	133	29	of	of	IN
cord-321401-w4ne60fn	133	30	disturbing	disturbing	JJ
cord-321401-w4ne60fn	133	31	and	and	CC
cord-321401-w4ne60fn	133	32	stressful	stressful	JJ
cord-321401-w4ne60fn	133	33	agents	agent	NNS
cord-321401-w4ne60fn	133	34	(	(	-LRB-
cord-321401-w4ne60fn	133	35	3	3	CD
cord-321401-w4ne60fn	133	36	,	,	,
cord-321401-w4ne60fn	133	37	93	93	CD
cord-321401-w4ne60fn	133	38	)	)	-RRB-
cord-321401-w4ne60fn	134	1	(	(	-LRB-
cord-321401-w4ne60fn	134	2	Figure	figure	NN
cord-321401-w4ne60fn	134	3	2	2	CD
cord-321401-w4ne60fn	134	4	)	)	-RRB-
cord-321401-w4ne60fn	134	5	.	.	.
cord-321401-w4ne60fn	135	1	In	in	IN
cord-321401-w4ne60fn	135	2	chronic	chronic	JJ
cord-321401-w4ne60fn	135	3	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	135	4	lung	lung	NN
cord-321401-w4ne60fn	135	5	diseases	disease	NNS
cord-321401-w4ne60fn	135	6	,	,	,
cord-321401-w4ne60fn	135	7	epithelial	epithelial	JJ
cord-321401-w4ne60fn	135	8	barrier	barrier	NN
cord-321401-w4ne60fn	135	9	function	function	NN
cord-321401-w4ne60fn	135	10	is	be	VBZ
cord-321401-w4ne60fn	135	11	impaired	impair	VBN
cord-321401-w4ne60fn	135	12	,	,	,
cord-321401-w4ne60fn	135	13	and	and	CC
cord-321401-w4ne60fn	135	14	as	as	IN
cord-321401-w4ne60fn	135	15	a	a	DT
cord-321401-w4ne60fn	135	16	consequence	consequence	NN
cord-321401-w4ne60fn	135	17	the	the	DT
cord-321401-w4ne60fn	135	18	susceptibility	susceptibility	NN
cord-321401-w4ne60fn	135	19	toward	toward	IN
cord-321401-w4ne60fn	135	20	respiratory	respiratory	JJ
cord-321401-w4ne60fn	135	21	infections	infection	NNS
cord-321401-w4ne60fn	135	22	is	be	VBZ
cord-321401-w4ne60fn	135	23	increased	increase	VBN
cord-321401-w4ne60fn	135	24	(	(	-LRB-
cord-321401-w4ne60fn	135	25	94	94	CD
cord-321401-w4ne60fn	135	26	)	)	-RRB-
cord-321401-w4ne60fn	135	27	.	.	.
cord-321401-w4ne60fn	136	1	There	there	EX
cord-321401-w4ne60fn	136	2	is	be	VBZ
cord-321401-w4ne60fn	136	3	increasing	increase	VBG
cord-321401-w4ne60fn	136	4	evidence	evidence	NN
cord-321401-w4ne60fn	136	5	that	that	IN
cord-321401-w4ne60fn	136	6	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	136	7	)	)	-RRB-
cord-321401-w4ne60fn	137	1	2	2	LS
cord-321401-w4ne60fn	137	2	D	d	NN
cord-321401-w4ne60fn	137	3	promotes	promote	VBZ
cord-321401-w4ne60fn	137	4	epithelial	epithelial	JJ
cord-321401-w4ne60fn	137	5	barrier	barrier	NN
cord-321401-w4ne60fn	137	6	integrity	integrity	NN
cord-321401-w4ne60fn	137	7	or	or	CC
cord-321401-w4ne60fn	137	8	protects	protect	VBZ
cord-321401-w4ne60fn	137	9	against	against	IN
cord-321401-w4ne60fn	137	10	epithelial	epithelial	JJ
cord-321401-w4ne60fn	137	11	barrier	barrier	NN
cord-321401-w4ne60fn	137	12	destruction	destruction	NN
cord-321401-w4ne60fn	137	13	.	.	.
cord-321401-w4ne60fn	138	1	In	in	IN
cord-321401-w4ne60fn	138	2	cells	cell	NNS
cord-321401-w4ne60fn	138	3	of	of	IN
cord-321401-w4ne60fn	138	4	the	the	DT
cord-321401-w4ne60fn	138	5	bronchial	bronchial	JJ
cord-321401-w4ne60fn	138	6	epithelial	epithelial	JJ
cord-321401-w4ne60fn	138	7	cell	cell	NN
cord-321401-w4ne60fn	138	8	line	line	NN
cord-321401-w4ne60fn	138	9	16HBE	16hbe	CD
cord-321401-w4ne60fn	138	10	,	,	,
cord-321401-w4ne60fn	138	11	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	138	12	)	)	-RRB-
cord-321401-w4ne60fn	138	13	2	2	CD
cord-321401-w4ne60fn	138	14	D	d	NN
cord-321401-w4ne60fn	138	15	inhibited	inhibit	VBN
cord-321401-w4ne60fn	138	16	CSEmediated	csemediated	JJ
cord-321401-w4ne60fn	138	17	reduction	reduction	NN
cord-321401-w4ne60fn	138	18	of	of	IN
cord-321401-w4ne60fn	138	19	the	the	DT
cord-321401-w4ne60fn	138	20	epithelial	epithelial	JJ
cord-321401-w4ne60fn	138	21	barrier	barrier	NN
cord-321401-w4ne60fn	138	22	and	and	CC
cord-321401-w4ne60fn	138	23	expression	expression	NN
cord-321401-w4ne60fn	138	24	of	of	IN
cord-321401-w4ne60fn	138	25	(	(	-LRB-
cord-321401-w4ne60fn	138	26	97	97	CD
cord-321401-w4ne60fn	138	27	)	)	-RRB-
cord-321401-w4ne60fn	138	28	.	.	.
cord-321401-w4ne60fn	139	1	Only	only	RB
cord-321401-w4ne60fn	139	2	the	the	DT
cord-321401-w4ne60fn	139	3	first	first	JJ
cord-321401-w4ne60fn	139	4	study	study	NN
cord-321401-w4ne60fn	139	5	that	that	WDT
cord-321401-w4ne60fn	139	6	used	use	VBD
cord-321401-w4ne60fn	139	7	a	a	DT
cord-321401-w4ne60fn	139	8	more	more	RBR
cord-321401-w4ne60fn	139	9	severe	severe	JJ
cord-321401-w4ne60fn	139	10	mouse	mouse	NN
cord-321401-w4ne60fn	139	11	model	model	NN
cord-321401-w4ne60fn	139	12	with	with	IN
cord-321401-w4ne60fn	139	13	higher	high	JJR
cord-321401-w4ne60fn	139	14	levels	level	NNS
cord-321401-w4ne60fn	139	15	of	of	IN
cord-321401-w4ne60fn	139	16	inflammation	inflammation	NN
cord-321401-w4ne60fn	139	17	and	and	CC
cord-321401-w4ne60fn	139	18	edema	edema	NN
cord-321401-w4ne60fn	139	19	found	find	VBD
cord-321401-w4ne60fn	139	20	an	an	DT
cord-321401-w4ne60fn	139	21	effect	effect	NN
cord-321401-w4ne60fn	139	22	of	of	IN
cord-321401-w4ne60fn	139	23	vitamin	vitamin	NN
cord-321401-w4ne60fn	139	24	D	d	NN
cord-321401-w4ne60fn	139	25	on	on	IN
cord-321401-w4ne60fn	139	26	epithelial	epithelial	JJ
cord-321401-w4ne60fn	139	27	barrier	barrier	NN
cord-321401-w4ne60fn	139	28	function	function	NN
cord-321401-w4ne60fn	139	29	.	.	.
cord-321401-w4ne60fn	140	1	Since	since	IN
cord-321401-w4ne60fn	140	2	inflammation	inflammation	NN
cord-321401-w4ne60fn	140	3	is	be	VBZ
cord-321401-w4ne60fn	140	4	detrimental	detrimental	JJ
cord-321401-w4ne60fn	140	5	for	for	IN
cord-321401-w4ne60fn	140	6	epithelial	epithelial	JJ
cord-321401-w4ne60fn	140	7	barrier	barrier	NN
cord-321401-w4ne60fn	140	8	integrity	integrity	NN
cord-321401-w4ne60fn	140	9	(	(	-LRB-
cord-321401-w4ne60fn	140	10	98	98	CD
cord-321401-w4ne60fn	140	11	)	)	-RRB-
cord-321401-w4ne60fn	140	12	,	,	,
cord-321401-w4ne60fn	140	13	it	-PRON-	PRP
cord-321401-w4ne60fn	140	14	can	can	MD
cord-321401-w4ne60fn	140	15	not	not	RB
cord-321401-w4ne60fn	140	16	be	be	VB
cord-321401-w4ne60fn	140	17	excluded	exclude	VBN
cord-321401-w4ne60fn	140	18	that	that	IN
cord-321401-w4ne60fn	140	19	the	the	DT
cord-321401-w4ne60fn	140	20	main	main	JJ
cord-321401-w4ne60fn	140	21	protective	protective	JJ
cord-321401-w4ne60fn	140	22	effects	effect	NNS
cord-321401-w4ne60fn	140	23	of	of	IN
cord-321401-w4ne60fn	140	24	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	140	25	)	)	-RRB-
cord-321401-w4ne60fn	140	26	2	2	CD
cord-321401-w4ne60fn	140	27	D	d	NN
cord-321401-w4ne60fn	140	28	on	on	IN
cord-321401-w4ne60fn	140	29	the	the	DT
cord-321401-w4ne60fn	140	30	epithelial	epithelial	JJ
cord-321401-w4ne60fn	140	31	barrier	barrier	NN
cord-321401-w4ne60fn	140	32	in	in	IN
cord-321401-w4ne60fn	140	33	the	the	DT
cord-321401-w4ne60fn	140	34	first	first	JJ
cord-321401-w4ne60fn	140	35	study	study	NN
cord-321401-w4ne60fn	140	36	by	by	IN
cord-321401-w4ne60fn	140	37	Shi	Shi	NNP
cord-321401-w4ne60fn	140	38	et	et	FW
cord-321401-w4ne60fn	140	39	al	al	NNP
cord-321401-w4ne60fn	140	40	.	.	NNP
cord-321401-w4ne60fn	140	41	were	be	VBD
cord-321401-w4ne60fn	140	42	in	in	IN
cord-321401-w4ne60fn	140	43	fact	fact	NN
cord-321401-w4ne60fn	140	44	exerted	exert	VBN
cord-321401-w4ne60fn	140	45	through	through	IN
cord-321401-w4ne60fn	140	46	inhibition	inhibition	NN
cord-321401-w4ne60fn	140	47	of	of	IN
cord-321401-w4ne60fn	140	48	inflammation	inflammation	NN
cord-321401-w4ne60fn	140	49	rather	rather	RB
cord-321401-w4ne60fn	140	50	than	than	IN
cord-321401-w4ne60fn	140	51	via	via	IN
cord-321401-w4ne60fn	140	52	direct	direct	JJ
cord-321401-w4ne60fn	140	53	induction	induction	NN
cord-321401-w4ne60fn	140	54	of	of	IN
cord-321401-w4ne60fn	140	55	cell	cell	NN
cord-321401-w4ne60fn	140	56	junction	junction	NN
cord-321401-w4ne60fn	140	57	proteins	protein	NNS
cord-321401-w4ne60fn	140	58	.	.	.
cord-321401-w4ne60fn	141	1	1,25(OH	1,25(oh	LS
cord-321401-w4ne60fn	141	2	)	)	-RRB-
cord-321401-w4ne60fn	141	3	2	2	CD
cord-321401-w4ne60fn	141	4	D	d	NN
cord-321401-w4ne60fn	141	5	might	may	MD
cord-321401-w4ne60fn	141	6	also	also	RB
cord-321401-w4ne60fn	141	7	promote	promote	VB
cord-321401-w4ne60fn	141	8	epithelial	epithelial	JJ
cord-321401-w4ne60fn	141	9	barrier	barrier	NN
cord-321401-w4ne60fn	141	10	function	function	NN
cord-321401-w4ne60fn	141	11	through	through	IN
cord-321401-w4ne60fn	141	12	its	-PRON-	PRP$
cord-321401-w4ne60fn	141	13	ability	ability	NN
cord-321401-w4ne60fn	141	14	to	to	TO
cord-321401-w4ne60fn	141	15	increase	increase	VB
cord-321401-w4ne60fn	141	16	expression	expression	NN
cord-321401-w4ne60fn	141	17	of	of	IN
cord-321401-w4ne60fn	141	18	cystic	cystic	JJ
cord-321401-w4ne60fn	141	19	fibrosis	fibrosis	NN
cord-321401-w4ne60fn	141	20	transmembrane	transmembrane	NNP
cord-321401-w4ne60fn	141	21	conductance	conductance	NN
cord-321401-w4ne60fn	141	22	regulator	regulator	NN
cord-321401-w4ne60fn	141	23	(	(	-LRB-
cord-321401-w4ne60fn	141	24	CFTR	CFTR	NNP
cord-321401-w4ne60fn	141	25	)	)	-RRB-
cord-321401-w4ne60fn	141	26	in	in	IN
cord-321401-w4ne60fn	141	27	airway	airway	JJ
cord-321401-w4ne60fn	141	28	epithelial	epithelial	JJ
cord-321401-w4ne60fn	141	29	cells	cell	NNS
cord-321401-w4ne60fn	141	30	(	(	-LRB-
cord-321401-w4ne60fn	141	31	32	32	CD
cord-321401-w4ne60fn	141	32	)	)	-RRB-
cord-321401-w4ne60fn	141	33	.	.	.
cord-321401-w4ne60fn	142	1	CFTR	CFTR	NNP
cord-321401-w4ne60fn	142	2	maintains	maintain	VBZ
cord-321401-w4ne60fn	142	3	optimal	optimal	JJ
cord-321401-w4ne60fn	142	4	ASL	asl	NN
cord-321401-w4ne60fn	142	5	-	-	:
cord-321401-w4ne60fn	142	6	and	and	CC
cord-321401-w4ne60fn	142	7	mucus	mucus	NN
cord-321401-w4ne60fn	142	8	hydration	hydration	NN
cord-321401-w4ne60fn	142	9	,	,	,
cord-321401-w4ne60fn	142	10	volume	volume	NN
cord-321401-w4ne60fn	142	11	and	and	CC
cord-321401-w4ne60fn	142	12	pH	ph	NN
cord-321401-w4ne60fn	142	13	that	that	WDT
cord-321401-w4ne60fn	142	14	support	support	VBP
cord-321401-w4ne60fn	142	15	mucociliary	mucociliary	JJ
cord-321401-w4ne60fn	142	16	clearance	clearance	NN
cord-321401-w4ne60fn	142	17	and	and	CC
cord-321401-w4ne60fn	142	18	activity	activity	NN
cord-321401-w4ne60fn	142	19	of	of	IN
cord-321401-w4ne60fn	142	20	AMPs	amp	NNS
cord-321401-w4ne60fn	142	21	(	(	-LRB-
cord-321401-w4ne60fn	142	22	99	99	CD
cord-321401-w4ne60fn	142	23	)	)	-RRB-
cord-321401-w4ne60fn	142	24	.	.	.
cord-321401-w4ne60fn	143	1	Moreover	moreover	RB
cord-321401-w4ne60fn	143	2	,	,	,
cord-321401-w4ne60fn	143	3	CFTR	CFTR	NNP
cord-321401-w4ne60fn	143	4	is	be	VBZ
cord-321401-w4ne60fn	143	5	also	also	RB
cord-321401-w4ne60fn	143	6	affected	affect	VBN
cord-321401-w4ne60fn	143	7	in	in	IN
cord-321401-w4ne60fn	143	8	the	the	DT
cord-321401-w4ne60fn	143	9	airways	airway	NNS
cord-321401-w4ne60fn	143	10	of	of	IN
cord-321401-w4ne60fn	143	11	smokers	smoker	NNS
cord-321401-w4ne60fn	143	12	and	and	CC
cord-321401-w4ne60fn	143	13	COPD	COPD	NNP
cord-321401-w4ne60fn	143	14	patients	patient	NNS
cord-321401-w4ne60fn	143	15	(	(	-LRB-
cord-321401-w4ne60fn	143	16	100	100	CD
cord-321401-w4ne60fn	143	17	)	)	-RRB-
cord-321401-w4ne60fn	143	18	.	.	.
cord-321401-w4ne60fn	144	1	In	in	IN
cord-321401-w4ne60fn	144	2	summary	summary	NN
cord-321401-w4ne60fn	144	3	,	,	,
cord-321401-w4ne60fn	144	4	these	these	DT
cord-321401-w4ne60fn	144	5	studies	study	NNS
cord-321401-w4ne60fn	144	6	indicate	indicate	VBP
cord-321401-w4ne60fn	144	7	that	that	IN
cord-321401-w4ne60fn	144	8	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	144	9	)	)	-RRB-
cord-321401-w4ne60fn	145	1	2	2	LS
cord-321401-w4ne60fn	145	2	D	D	NNP
cord-321401-w4ne60fn	145	3	promotes	promote	VBZ
cord-321401-w4ne60fn	145	4	both	both	CC
cord-321401-w4ne60fn	145	5	the	the	DT
cord-321401-w4ne60fn	145	6	integrity	integrity	NN
cord-321401-w4ne60fn	145	7	and	and	CC
cord-321401-w4ne60fn	145	8	function	function	NN
cord-321401-w4ne60fn	145	9	of	of	IN
cord-321401-w4ne60fn	145	10	the	the	DT
cord-321401-w4ne60fn	145	11	epithelial	epithelial	JJ
cord-321401-w4ne60fn	145	12	barrier	barrier	NN
cord-321401-w4ne60fn	145	13	and	and	CC
cord-321401-w4ne60fn	145	14	might	may	MD
cord-321401-w4ne60fn	145	15	additionally	additionally	RB
cord-321401-w4ne60fn	145	16	protect	protect	VB
cord-321401-w4ne60fn	145	17	against	against	IN
cord-321401-w4ne60fn	145	18	epithelial	epithelial	JJ
cord-321401-w4ne60fn	145	19	damage	damage	NN
cord-321401-w4ne60fn	145	20	by	by	IN
cord-321401-w4ne60fn	145	21	dampening	dampen	VBG
cord-321401-w4ne60fn	145	22	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	145	23	responses	response	NNS
cord-321401-w4ne60fn	145	24	.	.	.
cord-321401-w4ne60fn	146	1	The	the	DT
cord-321401-w4ne60fn	146	2	loss	loss	NN
cord-321401-w4ne60fn	146	3	of	of	IN
cord-321401-w4ne60fn	146	4	epithelial	epithelial	JJ
cord-321401-w4ne60fn	146	5	barrier	barrier	NN
cord-321401-w4ne60fn	146	6	function	function	NN
cord-321401-w4ne60fn	146	7	with	with	IN
cord-321401-w4ne60fn	146	8	a	a	DT
cord-321401-w4ne60fn	146	9	decrease	decrease	NN
cord-321401-w4ne60fn	146	10	in	in	IN
cord-321401-w4ne60fn	146	11	epithelial	epithelial	JJ
cord-321401-w4ne60fn	146	12	polarization	polarization	NN
cord-321401-w4ne60fn	146	13	and	and	CC
cord-321401-w4ne60fn	146	14	cell	cell	NN
cord-321401-w4ne60fn	146	15	-	-	HYPH
cord-321401-w4ne60fn	146	16	junction	junction	NN
cord-321401-w4ne60fn	146	17	proteins	protein	NNS
cord-321401-w4ne60fn	146	18	and	and	CC
cord-321401-w4ne60fn	146	19	a	a	DT
cord-321401-w4ne60fn	146	20	gain	gain	NN
cord-321401-w4ne60fn	146	21	of	of	IN
cord-321401-w4ne60fn	146	22	expression	expression	NN
cord-321401-w4ne60fn	146	23	of	of	IN
cord-321401-w4ne60fn	146	24	mesenchymal	mesenchymal	JJ
cord-321401-w4ne60fn	146	25	markers	marker	NNS
cord-321401-w4ne60fn	146	26	is	be	VBZ
cord-321401-w4ne60fn	146	27	a	a	DT
cord-321401-w4ne60fn	146	28	hallmark	hallmark	NN
cord-321401-w4ne60fn	146	29	of	of	IN
cord-321401-w4ne60fn	146	30	EMT	EMT	NNP
cord-321401-w4ne60fn	146	31	(	(	-LRB-
cord-321401-w4ne60fn	146	32	94	94	CD
cord-321401-w4ne60fn	146	33	)	)	-RRB-
cord-321401-w4ne60fn	146	34	.	.	.
cord-321401-w4ne60fn	147	1	EMT	EMT	NNP
cord-321401-w4ne60fn	147	2	is	be	VBZ
cord-321401-w4ne60fn	147	3	primarily	primarily	RB
cord-321401-w4ne60fn	147	4	involved	involve	VBN
cord-321401-w4ne60fn	147	5	in	in	IN
cord-321401-w4ne60fn	147	6	development	development	NN
cord-321401-w4ne60fn	147	7	,	,	,
cord-321401-w4ne60fn	147	8	wound	wound	VB
cord-321401-w4ne60fn	147	9	healing	healing	NN
cord-321401-w4ne60fn	147	10	and	and	CC
cord-321401-w4ne60fn	147	11	stem	stem	NN
cord-321401-w4ne60fn	147	12	cell	cell	NN
cord-321401-w4ne60fn	147	13	differentiation	differentiation	NN
cord-321401-w4ne60fn	147	14	,	,	,
cord-321401-w4ne60fn	147	15	and	and	CC
cord-321401-w4ne60fn	147	16	TGF	TGF	NNP
cord-321401-w4ne60fn	147	17	-	-	HYPH
cord-321401-w4ne60fn	147	18	β	β	NNP
cord-321401-w4ne60fn	147	19	signaling	signaling	NN
cord-321401-w4ne60fn	147	20	plays	play	VBZ
cord-321401-w4ne60fn	147	21	a	a	DT
cord-321401-w4ne60fn	147	22	major	major	JJ
cord-321401-w4ne60fn	147	23	role	role	NN
cord-321401-w4ne60fn	147	24	in	in	IN
cord-321401-w4ne60fn	147	25	this	this	DT
cord-321401-w4ne60fn	147	26	process	process	NN
cord-321401-w4ne60fn	147	27	(	(	-LRB-
cord-321401-w4ne60fn	147	28	101	101	CD
cord-321401-w4ne60fn	147	29	)	)	-RRB-
cord-321401-w4ne60fn	147	30	.	.	.
cord-321401-w4ne60fn	148	1	Elevated	elevated	JJ
cord-321401-w4ne60fn	148	2	TGF	TGF	NNP
cord-321401-w4ne60fn	148	3	-	-	HYPH
cord-321401-w4ne60fn	148	4	β1	β1	NNP
cord-321401-w4ne60fn	148	5	levels	level	NNS
cord-321401-w4ne60fn	148	6	are	be	VBP
cord-321401-w4ne60fn	148	7	found	find	VBN
cord-321401-w4ne60fn	148	8	in	in	IN
cord-321401-w4ne60fn	148	9	the	the	DT
cord-321401-w4ne60fn	148	10	lungs	lung	NNS
cord-321401-w4ne60fn	148	11	of	of	IN
cord-321401-w4ne60fn	148	12	patients	patient	NNS
cord-321401-w4ne60fn	148	13	with	with	IN
cord-321401-w4ne60fn	148	14	chronic	chronic	JJ
cord-321401-w4ne60fn	148	15	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	148	16	lung	lung	NN
cord-321401-w4ne60fn	148	17	diseases	disease	NNS
cord-321401-w4ne60fn	148	18	and	and	CC
cord-321401-w4ne60fn	148	19	this	this	DT
cord-321401-w4ne60fn	148	20	was	be	VBD
cord-321401-w4ne60fn	148	21	associated	associate	VBN
cord-321401-w4ne60fn	148	22	with	with	IN
cord-321401-w4ne60fn	148	23	cigarette	cigarette	NN
cord-321401-w4ne60fn	148	24	smoking	smoking	NN
cord-321401-w4ne60fn	148	25	,	,	,
cord-321401-w4ne60fn	148	26	inflammation	inflammation	NN
cord-321401-w4ne60fn	148	27	and	and	CC
cord-321401-w4ne60fn	148	28	fibrosis	fibrosis	NN
cord-321401-w4ne60fn	148	29	(	(	-LRB-
cord-321401-w4ne60fn	148	30	80	80	CD
cord-321401-w4ne60fn	148	31	,	,	,
cord-321401-w4ne60fn	148	32	102	102	CD
cord-321401-w4ne60fn	148	33	)	)	-RRB-
cord-321401-w4ne60fn	148	34	.	.	.
cord-321401-w4ne60fn	149	1	There	there	EX
cord-321401-w4ne60fn	149	2	are	be	VBP
cord-321401-w4ne60fn	149	3	indications	indication	NNS
cord-321401-w4ne60fn	149	4	that	that	IN
cord-321401-w4ne60fn	149	5	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	149	6	)	)	-RRB-
cord-321401-w4ne60fn	149	7	2	2	CD
cord-321401-w4ne60fn	149	8	D	d	NN
cord-321401-w4ne60fn	149	9	counteracts	counteract	VBZ
cord-321401-w4ne60fn	149	10	various	various	JJ
cord-321401-w4ne60fn	149	11	pathways	pathway	NNS
cord-321401-w4ne60fn	149	12	leading	lead	VBG
cord-321401-w4ne60fn	149	13	to	to	IN
cord-321401-w4ne60fn	149	14	EMT	EMT	NNP
cord-321401-w4ne60fn	149	15	.	.	.
cord-321401-w4ne60fn	150	1	In	in	IN
cord-321401-w4ne60fn	150	2	mouse	mouse	NN
cord-321401-w4ne60fn	150	3	models	model	NNS
cord-321401-w4ne60fn	150	4	and	and	CC
cord-321401-w4ne60fn	150	5	in	in	IN
cord-321401-w4ne60fn	150	6	airway	airway	JJ
cord-321401-w4ne60fn	150	7	epithelial	epithelial	JJ
cord-321401-w4ne60fn	150	8	cell	cell	NN
cord-321401-w4ne60fn	150	9	lines	line	NNS
cord-321401-w4ne60fn	150	10	,	,	,
cord-321401-w4ne60fn	150	11	vitamin	vitamin	NN
cord-321401-w4ne60fn	150	12	D	d	NN
cord-321401-w4ne60fn	150	13	supplementation	supplementation	NN
cord-321401-w4ne60fn	150	14	and	and	CC
cord-321401-w4ne60fn	150	15	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	150	16	)	)	-RRB-
cord-321401-w4ne60fn	150	17	2	2	CD
cord-321401-w4ne60fn	150	18	D	d	NN
cord-321401-w4ne60fn	150	19	,	,	,
cord-321401-w4ne60fn	150	20	respectively	respectively	RB
cord-321401-w4ne60fn	150	21	,	,	,
cord-321401-w4ne60fn	150	22	has	have	VBZ
cord-321401-w4ne60fn	150	23	been	be	VBN
cord-321401-w4ne60fn	150	24	shown	show	VBN
cord-321401-w4ne60fn	150	25	to	to	TO
cord-321401-w4ne60fn	150	26	inhibit	inhibit	VB
cord-321401-w4ne60fn	150	27	EMT	EMT	NNP
cord-321401-w4ne60fn	150	28	and	and	CC
cord-321401-w4ne60fn	150	29	fibrosis	fibrosis	NN
cord-321401-w4ne60fn	150	30	,	,	,
cord-321401-w4ne60fn	150	31	in	in	IN
cord-321401-w4ne60fn	150	32	particular	particular	JJ
cord-321401-w4ne60fn	150	33	when	when	WRB
cord-321401-w4ne60fn	150	34	this	this	DT
cord-321401-w4ne60fn	150	35	process	process	NN
cord-321401-w4ne60fn	150	36	is	be	VBZ
cord-321401-w4ne60fn	150	37	induced	induce	VBN
cord-321401-w4ne60fn	150	38	by	by	IN
cord-321401-w4ne60fn	150	39	TGF	TGF	NNP
cord-321401-w4ne60fn	150	40	-	-	HYPH
cord-321401-w4ne60fn	150	41	β1	β1	NNP
cord-321401-w4ne60fn	150	42	(	(	-LRB-
cord-321401-w4ne60fn	150	43	88	88	CD
cord-321401-w4ne60fn	150	44	,	,	,
cord-321401-w4ne60fn	150	45	(	(	-LRB-
cord-321401-w4ne60fn	150	46	103	103	CD
cord-321401-w4ne60fn	150	47	)	)	-RRB-
cord-321401-w4ne60fn	150	48	(	(	-LRB-
cord-321401-w4ne60fn	150	49	104	104	CD
cord-321401-w4ne60fn	150	50	)	)	-RRB-
cord-321401-w4ne60fn	150	51	(	(	-LRB-
cord-321401-w4ne60fn	150	52	105	105	CD
cord-321401-w4ne60fn	150	53	)	)	-RRB-
cord-321401-w4ne60fn	150	54	(	(	-LRB-
cord-321401-w4ne60fn	150	55	106	106	CD
cord-321401-w4ne60fn	150	56	)	)	-RRB-
cord-321401-w4ne60fn	150	57	.	.	.
cord-321401-w4ne60fn	151	1	In	in	IN
cord-321401-w4ne60fn	151	2	addition	addition	NN
cord-321401-w4ne60fn	151	3	to	to	IN
cord-321401-w4ne60fn	151	4	maintenance	maintenance	NN
cord-321401-w4ne60fn	151	5	of	of	IN
cord-321401-w4ne60fn	151	6	the	the	DT
cord-321401-w4ne60fn	151	7	epithelial	epithelial	JJ
cord-321401-w4ne60fn	151	8	barrier	barrier	NN
cord-321401-w4ne60fn	151	9	and	and	CC
cord-321401-w4ne60fn	151	10	inhibition	inhibition	NN
cord-321401-w4ne60fn	151	11	of	of	IN
cord-321401-w4ne60fn	151	12	fibrosis	fibrosis	NN
cord-321401-w4ne60fn	151	13	as	as	IN
cord-321401-w4ne60fn	151	14	discussed	discuss	VBN
cord-321401-w4ne60fn	151	15	in	in	IN
cord-321401-w4ne60fn	151	16	the	the	DT
cord-321401-w4ne60fn	151	17	previous	previous	JJ
cord-321401-w4ne60fn	151	18	paragraphs	paragraph	NNS
cord-321401-w4ne60fn	151	19	,	,	,
cord-321401-w4ne60fn	151	20	vitamin	vitamin	NN
cord-321401-w4ne60fn	151	21	D	d	NN
cord-321401-w4ne60fn	151	22	is	be	VBZ
cord-321401-w4ne60fn	151	23	also	also	RB
cord-321401-w4ne60fn	151	24	actively	actively	RB
cord-321401-w4ne60fn	151	25	involved	involve	VBN
cord-321401-w4ne60fn	151	26	in	in	IN
cord-321401-w4ne60fn	151	27	respiratory	respiratory	JJ
cord-321401-w4ne60fn	151	28	host	host	NN
cord-321401-w4ne60fn	151	29	defense	defense	NN
cord-321401-w4ne60fn	151	30	by	by	IN
cord-321401-w4ne60fn	151	31	a	a	DT
cord-321401-w4ne60fn	151	32	variety	variety	NN
cord-321401-w4ne60fn	151	33	of	of	IN
cord-321401-w4ne60fn	151	34	mechanisms	mechanism	NNS
cord-321401-w4ne60fn	151	35	(	(	-LRB-
cord-321401-w4ne60fn	151	36	3	3	CD
cord-321401-w4ne60fn	151	37	,	,	,
cord-321401-w4ne60fn	151	38	29	29	CD
cord-321401-w4ne60fn	151	39	)	)	-RRB-
cord-321401-w4ne60fn	151	40	.	.	.
cord-321401-w4ne60fn	152	1	1,25(OH	1,25(oh	LS
cord-321401-w4ne60fn	152	2	)	)	-RRB-
cord-321401-w4ne60fn	153	1	2	2	LS
cord-321401-w4ne60fn	153	2	D	d	NN
cord-321401-w4ne60fn	153	3	is	be	VBZ
cord-321401-w4ne60fn	153	4	an	an	DT
cord-321401-w4ne60fn	153	5	important	important	JJ
cord-321401-w4ne60fn	153	6	inducer	inducer	NN
cord-321401-w4ne60fn	153	7	of	of	IN
cord-321401-w4ne60fn	153	8	AMPs	amp	NNS
cord-321401-w4ne60fn	153	9	,	,	,
cord-321401-w4ne60fn	153	10	which	which	WDT
cord-321401-w4ne60fn	153	11	are	be	VBP
cord-321401-w4ne60fn	153	12	mostly	mostly	RB
cord-321401-w4ne60fn	153	13	cationic	cationic	JJ
cord-321401-w4ne60fn	153	14	peptides	peptide	NNS
cord-321401-w4ne60fn	153	15	that	that	WDT
cord-321401-w4ne60fn	153	16	have	have	VBP
cord-321401-w4ne60fn	153	17	a	a	DT
cord-321401-w4ne60fn	153	18	broad	broad	JJ
cord-321401-w4ne60fn	153	19	-	-	HYPH
cord-321401-w4ne60fn	153	20	spectrum	spectrum	NN
cord-321401-w4ne60fn	153	21	antimicrobial	antimicrobial	JJ
cord-321401-w4ne60fn	153	22	activity	activity	NN
cord-321401-w4ne60fn	153	23	,	,	,
cord-321401-w4ne60fn	153	24	the	the	DT
cord-321401-w4ne60fn	153	25	ability	ability	NN
cord-321401-w4ne60fn	153	26	to	to	TO
cord-321401-w4ne60fn	153	27	modulate	modulate	VB
cord-321401-w4ne60fn	153	28	immune	immune	JJ
cord-321401-w4ne60fn	153	29	responses	response	NNS
cord-321401-w4ne60fn	153	30	and	and	CC
cord-321401-w4ne60fn	153	31	to	to	TO
cord-321401-w4ne60fn	153	32	promote	promote	VB
cord-321401-w4ne60fn	153	33	epithelial	epithelial	JJ
cord-321401-w4ne60fn	153	34	wound	wound	NN
cord-321401-w4ne60fn	153	35	repair	repair	NN
cord-321401-w4ne60fn	153	36	and	and	CC
cord-321401-w4ne60fn	153	37	angiogenesis	angiogenesis	NN
cord-321401-w4ne60fn	153	38	(	(	-LRB-
cord-321401-w4ne60fn	153	39	107	107	CD
cord-321401-w4ne60fn	153	40	)	)	-RRB-
cord-321401-w4ne60fn	153	41	.	.	.
cord-321401-w4ne60fn	154	1	hCAP18	hCAP18	NNP
cord-321401-w4ne60fn	154	2	/	/	SYM
cord-321401-w4ne60fn	154	3	LL-37	LL-37	NNP
cord-321401-w4ne60fn	154	4	is	be	VBZ
cord-321401-w4ne60fn	154	5	likely	likely	JJ
cord-321401-w4ne60fn	154	6	to	to	TO
cord-321401-w4ne60fn	154	7	be	be	VB
cord-321401-w4ne60fn	154	8	the	the	DT
cord-321401-w4ne60fn	154	9	most	most	RBS
cord-321401-w4ne60fn	154	10	prominent	prominent	JJ
cord-321401-w4ne60fn	154	11	AMP	amp	NN
cord-321401-w4ne60fn	154	12	that	that	WDT
cord-321401-w4ne60fn	154	13	is	be	VBZ
cord-321401-w4ne60fn	154	14	induced	induce	VBN
cord-321401-w4ne60fn	154	15	by	by	IN
cord-321401-w4ne60fn	154	16	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	154	17	)	)	-RRB-
cord-321401-w4ne60fn	154	18	2	2	CD
cord-321401-w4ne60fn	154	19	D	d	NN
cord-321401-w4ne60fn	154	20	and	and	CC
cord-321401-w4ne60fn	154	21	is	be	VBZ
cord-321401-w4ne60fn	154	22	expressed	express	VBN
cord-321401-w4ne60fn	154	23	in	in	IN
cord-321401-w4ne60fn	154	24	several	several	JJ
cord-321401-w4ne60fn	154	25	types	type	NNS
cord-321401-w4ne60fn	154	26	of	of	IN
cord-321401-w4ne60fn	154	27	mucosal	mucosal	JJ
cord-321401-w4ne60fn	154	28	epithelial	epithelial	JJ
cord-321401-w4ne60fn	154	29	cells	cell	NNS
cord-321401-w4ne60fn	154	30	and	and	CC
cord-321401-w4ne60fn	154	31	immune	immune	JJ
cord-321401-w4ne60fn	154	32	cells	cell	NNS
cord-321401-w4ne60fn	154	33	such	such	JJ
cord-321401-w4ne60fn	154	34	as	as	IN
cord-321401-w4ne60fn	154	35	monocytes	monocyte	NNS
cord-321401-w4ne60fn	154	36	and	and	CC
cord-321401-w4ne60fn	154	37	neutrophils	neutrophil	NNS
cord-321401-w4ne60fn	154	38	(	(	-LRB-
cord-321401-w4ne60fn	154	39	38	38	CD
cord-321401-w4ne60fn	154	40	,	,	,
cord-321401-w4ne60fn	154	41	77	77	CD
cord-321401-w4ne60fn	154	42	,	,	,
cord-321401-w4ne60fn	154	43	108	108	CD
cord-321401-w4ne60fn	154	44	)	)	-RRB-
cord-321401-w4ne60fn	154	45	.	.	.
cord-321401-w4ne60fn	155	1	In	in	IN
cord-321401-w4ne60fn	155	2	macrophages	macrophage	NNS
cord-321401-w4ne60fn	155	3	and	and	CC
cord-321401-w4ne60fn	155	4	intestinal	intestinal	JJ
cord-321401-w4ne60fn	155	5	epithelial	epithelial	JJ
cord-321401-w4ne60fn	155	6	cells	cell	NNS
cord-321401-w4ne60fn	155	7	,	,	,
cord-321401-w4ne60fn	155	8	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	155	9	)	)	-RRB-
cord-321401-w4ne60fn	155	10	2	2	CD
cord-321401-w4ne60fn	155	11	D	d	NN
cord-321401-w4ne60fn	155	12	also	also	RB
cord-321401-w4ne60fn	155	13	increases	increase	VBZ
cord-321401-w4ne60fn	155	14	expression	expression	NN
cord-321401-w4ne60fn	155	15	of	of	IN
cord-321401-w4ne60fn	155	16	human	human	JJ
cord-321401-w4ne60fn	155	17	β	β	NN
cord-321401-w4ne60fn	155	18	-	-	HYPH
cord-321401-w4ne60fn	155	19	defensin-2	defensin-2	NNP
cord-321401-w4ne60fn	155	20	(	(	-LRB-
cord-321401-w4ne60fn	155	21	hBD-2	hBD-2	NNP
cord-321401-w4ne60fn	155	22	)	)	-RRB-
cord-321401-w4ne60fn	155	23	,	,	,
cord-321401-w4ne60fn	155	24	whereas	whereas	IN
cord-321401-w4ne60fn	155	25	in	in	IN
cord-321401-w4ne60fn	155	26	keratinocytes	keratinocyte	NNS
cord-321401-w4ne60fn	155	27	expression	expression	NN
cord-321401-w4ne60fn	155	28	of	of	IN
cord-321401-w4ne60fn	155	29	both	both	CC
cord-321401-w4ne60fn	155	30	hBD-2	hbd-2	JJ
cord-321401-w4ne60fn	155	31	and	and	CC
cord-321401-w4ne60fn	155	32	human	human	JJ
cord-321401-w4ne60fn	155	33	β	β	NNP
cord-321401-w4ne60fn	155	34	-	-	HYPH
cord-321401-w4ne60fn	155	35	defensin-3	defensin-3	NNP
cord-321401-w4ne60fn	155	36	(	(	-LRB-
cord-321401-w4ne60fn	155	37	hBD-3	hbd-3	NN
cord-321401-w4ne60fn	155	38	)	)	-RRB-
cord-321401-w4ne60fn	155	39	is	be	VBZ
cord-321401-w4ne60fn	155	40	increased	increase	VBN
cord-321401-w4ne60fn	155	41	by	by	IN
cord-321401-w4ne60fn	155	42	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	155	43	)	)	-RRB-
cord-321401-w4ne60fn	155	44	2	2	CD
cord-321401-w4ne60fn	155	45	D	d	NN
cord-321401-w4ne60fn	155	46	(	(	-LRB-
cord-321401-w4ne60fn	155	47	109	109	CD
cord-321401-w4ne60fn	155	48	)	)	-RRB-
cord-321401-w4ne60fn	155	49	(	(	-LRB-
cord-321401-w4ne60fn	155	50	110	110	CD
cord-321401-w4ne60fn	155	51	)	)	-RRB-
cord-321401-w4ne60fn	155	52	(	(	-LRB-
cord-321401-w4ne60fn	155	53	111	111	CD
cord-321401-w4ne60fn	155	54	)	)	-RRB-
cord-321401-w4ne60fn	155	55	(	(	-LRB-
cord-321401-w4ne60fn	155	56	112	112	CD
cord-321401-w4ne60fn	155	57	)	)	-RRB-
cord-321401-w4ne60fn	155	58	.	.	.
cord-321401-w4ne60fn	156	1	Collectively	collectively	RB
cord-321401-w4ne60fn	156	2	these	these	DT
cord-321401-w4ne60fn	156	3	data	datum	NNS
cord-321401-w4ne60fn	156	4	show	show	VBP
cord-321401-w4ne60fn	156	5	that	that	IN
cord-321401-w4ne60fn	156	6	AMPs	amp	NNS
cord-321401-w4ne60fn	156	7	are	be	VBP
cord-321401-w4ne60fn	156	8	modulated	modulate	VBN
cord-321401-w4ne60fn	156	9	by	by	IN
cord-321401-w4ne60fn	156	10	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	156	11	)	)	-RRB-
cord-321401-w4ne60fn	156	12	2	2	CD
cord-321401-w4ne60fn	156	13	D	d	NN
cord-321401-w4ne60fn	156	14	in	in	IN
cord-321401-w4ne60fn	156	15	mucosal	mucosal	JJ
cord-321401-w4ne60fn	156	16	tissues	tissue	NNS
cord-321401-w4ne60fn	156	17	,	,	,
cord-321401-w4ne60fn	156	18	which	which	WDT
cord-321401-w4ne60fn	156	19	could	could	MD
cord-321401-w4ne60fn	156	20	have	have	VB
cord-321401-w4ne60fn	156	21	impact	impact	NN
cord-321401-w4ne60fn	156	22	on	on	IN
cord-321401-w4ne60fn	156	23	susceptibility	susceptibility	NN
cord-321401-w4ne60fn	156	24	to	to	IN
cord-321401-w4ne60fn	156	25	both	both	DT
cord-321401-w4ne60fn	156	26	bacterial	bacterial	JJ
cord-321401-w4ne60fn	156	27	and	and	CC
cord-321401-w4ne60fn	156	28	viral	viral	JJ
cord-321401-w4ne60fn	156	29	infections	infection	NNS
cord-321401-w4ne60fn	156	30	and	and	CC
cord-321401-w4ne60fn	156	31	on	on	IN
cord-321401-w4ne60fn	156	32	the	the	DT
cord-321401-w4ne60fn	156	33	composition	composition	NN
cord-321401-w4ne60fn	156	34	of	of	IN
cord-321401-w4ne60fn	156	35	the	the	DT
cord-321401-w4ne60fn	156	36	microbiota	microbiota	NN
cord-321401-w4ne60fn	156	37	,	,	,
cord-321401-w4ne60fn	156	38	which	which	WDT
cord-321401-w4ne60fn	156	39	will	will	MD
cord-321401-w4ne60fn	156	40	be	be	VB
cord-321401-w4ne60fn	156	41	discussed	discuss	VBN
cord-321401-w4ne60fn	156	42	in	in	IN
cord-321401-w4ne60fn	156	43	the	the	DT
cord-321401-w4ne60fn	156	44	next	next	JJ
cord-321401-w4ne60fn	156	45	section	section	NN
cord-321401-w4ne60fn	156	46	.	.	.
cord-321401-w4ne60fn	157	1	Diseases	disease	NNS
cord-321401-w4ne60fn	157	2	such	such	JJ
cord-321401-w4ne60fn	157	3	as	as	IN
cord-321401-w4ne60fn	157	4	COPD	COPD	NNP
cord-321401-w4ne60fn	157	5	and	and	CC
cord-321401-w4ne60fn	157	6	asthma	asthma	NN
cord-321401-w4ne60fn	157	7	are	be	VBP
cord-321401-w4ne60fn	157	8	characterized	characterize	VBN
cord-321401-w4ne60fn	157	9	by	by	IN
cord-321401-w4ne60fn	157	10	chronic	chronic	JJ
cord-321401-w4ne60fn	157	11	inflammation	inflammation	NN
cord-321401-w4ne60fn	157	12	,	,	,
cord-321401-w4ne60fn	157	13	a	a	DT
cord-321401-w4ne60fn	157	14	low	low	JJ
cord-321401-w4ne60fn	157	15	-	-	HYPH
cord-321401-w4ne60fn	157	16	grade	grade	NN
cord-321401-w4ne60fn	157	17	and	and	CC
cord-321401-w4ne60fn	157	18	prolonged	prolonged	JJ
cord-321401-w4ne60fn	157	19	inflammation	inflammation	NN
cord-321401-w4ne60fn	157	20	that	that	WDT
cord-321401-w4ne60fn	157	21	may	may	MD
cord-321401-w4ne60fn	157	22	result	result	VB
cord-321401-w4ne60fn	157	23	in	in	IN
cord-321401-w4ne60fn	157	24	destruction	destruction	NN
cord-321401-w4ne60fn	157	25	and	and	CC
cord-321401-w4ne60fn	157	26	aberrant	aberrant	JJ
cord-321401-w4ne60fn	157	27	repair	repair	NN
cord-321401-w4ne60fn	157	28	of	of	IN
cord-321401-w4ne60fn	157	29	surrounding	surround	VBG
cord-321401-w4ne60fn	157	30	tissue	tissue	NN
cord-321401-w4ne60fn	157	31	by	by	IN
cord-321401-w4ne60fn	157	32	growth	growth	NN
cord-321401-w4ne60fn	157	33	factors	factor	NNS
cord-321401-w4ne60fn	157	34	,	,	,
cord-321401-w4ne60fn	157	35	proteases	protease	NNS
cord-321401-w4ne60fn	157	36	and	and	CC
cord-321401-w4ne60fn	157	37	cytokines	cytokine	NNS
cord-321401-w4ne60fn	157	38	that	that	WDT
cord-321401-w4ne60fn	157	39	are	be	VBP
cord-321401-w4ne60fn	157	40	released	release	VBN
cord-321401-w4ne60fn	157	41	at	at	IN
cord-321401-w4ne60fn	157	42	the	the	DT
cord-321401-w4ne60fn	157	43	site	site	NN
cord-321401-w4ne60fn	157	44	of	of	IN
cord-321401-w4ne60fn	157	45	inflammation	inflammation	NN
cord-321401-w4ne60fn	157	46	(	(	-LRB-
cord-321401-w4ne60fn	157	47	113	113	CD
cord-321401-w4ne60fn	157	48	)	)	-RRB-
cord-321401-w4ne60fn	157	49	(	(	-LRB-
cord-321401-w4ne60fn	157	50	114	114	CD
cord-321401-w4ne60fn	157	51	)	)	-RRB-
cord-321401-w4ne60fn	157	52	(	(	-LRB-
cord-321401-w4ne60fn	157	53	115	115	CD
cord-321401-w4ne60fn	157	54	)	)	-RRB-
cord-321401-w4ne60fn	157	55	.	.	.
cord-321401-w4ne60fn	158	1	Cumulative	cumulative	JJ
cord-321401-w4ne60fn	158	2	data	datum	NNS
cord-321401-w4ne60fn	158	3	suggest	suggest	VBP
cord-321401-w4ne60fn	158	4	that	that	IN
cord-321401-w4ne60fn	158	5	vitamin	vitamin	NN
cord-321401-w4ne60fn	158	6	D	d	NN
cord-321401-w4ne60fn	158	7	exerts	exert	VBZ
cord-321401-w4ne60fn	158	8	anti	anti	JJ
cord-321401-w4ne60fn	158	9	-	-	JJ
cord-321401-w4ne60fn	158	10	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	158	11	effects	effect	NNS
cord-321401-w4ne60fn	158	12	via	via	IN
cord-321401-w4ne60fn	158	13	its	-PRON-	PRP$
cord-321401-w4ne60fn	158	14	actions	action	NNS
cord-321401-w4ne60fn	158	15	on	on	IN
cord-321401-w4ne60fn	158	16	both	both	DT
cord-321401-w4ne60fn	158	17	innate	innate	JJ
cord-321401-w4ne60fn	158	18	and	and	CC
cord-321401-w4ne60fn	158	19	adaptive	adaptive	JJ
cord-321401-w4ne60fn	158	20	immune	immune	JJ
cord-321401-w4ne60fn	158	21	responses	response	NNS
cord-321401-w4ne60fn	158	22	.	.	.
cord-321401-w4ne60fn	159	1	Upon	upon	IN
cord-321401-w4ne60fn	159	2	viral	viral	JJ
cord-321401-w4ne60fn	159	3	infection	infection	NN
cord-321401-w4ne60fn	159	4	or	or	CC
cord-321401-w4ne60fn	159	5	exposure	exposure	NN
cord-321401-w4ne60fn	159	6	of	of	IN
cord-321401-w4ne60fn	159	7	pro	pro	JJ
cord-321401-w4ne60fn	159	8	-	-	JJ
cord-321401-w4ne60fn	159	9	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	159	10	stimuli	stimulus	NNS
cord-321401-w4ne60fn	159	11	such	such	JJ
cord-321401-w4ne60fn	159	12	as	as	IN
cord-321401-w4ne60fn	159	13	Poly(I	Poly(I	NNS
cord-321401-w4ne60fn	159	14	:	:	:
cord-321401-w4ne60fn	159	15	C	C	NNP
cord-321401-w4ne60fn	159	16	)	)	-RRB-
cord-321401-w4ne60fn	159	17	or	or	CC
cord-321401-w4ne60fn	159	18	PM	PM	NNP
cord-321401-w4ne60fn	159	19	,	,	,
cord-321401-w4ne60fn	159	20	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	159	21	)	)	-RRB-
cord-321401-w4ne60fn	160	1	2	2	LS
cord-321401-w4ne60fn	160	2	D	d	NN
cord-321401-w4ne60fn	160	3	attenuates	attenuate	VBZ
cord-321401-w4ne60fn	160	4	induced	induce	VBN
cord-321401-w4ne60fn	160	5	expression	expression	NN
cord-321401-w4ne60fn	160	6	of	of	IN
cord-321401-w4ne60fn	160	7	cytokines	cytokine	NNS
cord-321401-w4ne60fn	160	8	and	and	CC
cord-321401-w4ne60fn	160	9	chemokines	chemokine	NNS
cord-321401-w4ne60fn	161	1	e.g.	e.g.	RB
cord-321401-w4ne60fn	161	2	,	,	,
cord-321401-w4ne60fn	161	3	via	via	IN
cord-321401-w4ne60fn	161	4	inhibition	inhibition	NN
cord-321401-w4ne60fn	161	5	of	of	IN
cord-321401-w4ne60fn	161	6	nuclear	nuclear	JJ
cord-321401-w4ne60fn	161	7	factor	factor	NN
cord-321401-w4ne60fn	161	8	(	(	-LRB-
cord-321401-w4ne60fn	161	9	NF)-κB	nf)-κb	JJ
cord-321401-w4ne60fn	161	10	or	or	CC
cord-321401-w4ne60fn	161	11	oxidative	oxidative	JJ
cord-321401-w4ne60fn	161	12	stress	stress	NN
cord-321401-w4ne60fn	161	13	,	,	,
cord-321401-w4ne60fn	161	14	respectively	respectively	RB
cord-321401-w4ne60fn	161	15	,	,	,
cord-321401-w4ne60fn	161	16	in	in	IN
cord-321401-w4ne60fn	161	17	(	(	-LRB-
cord-321401-w4ne60fn	161	18	airway	airway	NN
cord-321401-w4ne60fn	161	19	)	)	-RRB-
cord-321401-w4ne60fn	161	20	epithelial	epithelial	JJ
cord-321401-w4ne60fn	161	21	cells	cell	NNS
cord-321401-w4ne60fn	161	22	(	(	-LRB-
cord-321401-w4ne60fn	161	23	38	38	CD
cord-321401-w4ne60fn	161	24	,	,	,
cord-321401-w4ne60fn	161	25	59	59	CD
cord-321401-w4ne60fn	161	26	,	,	,
cord-321401-w4ne60fn	161	27	116	116	CD
cord-321401-w4ne60fn	161	28	)	)	-RRB-
cord-321401-w4ne60fn	161	29	.	.	.
cord-321401-w4ne60fn	162	1	Furthermore	furthermore	RB
cord-321401-w4ne60fn	162	2	,	,	,
cord-321401-w4ne60fn	162	3	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	162	4	)	)	-RRB-
cord-321401-w4ne60fn	162	5	2	2	CD
cord-321401-w4ne60fn	162	6	D	d	NN
cord-321401-w4ne60fn	162	7	increases	increase	VBZ
cord-321401-w4ne60fn	162	8	expression	expression	NN
cord-321401-w4ne60fn	162	9	of	of	IN
cord-321401-w4ne60fn	162	10	the	the	DT
cord-321401-w4ne60fn	162	11	soluble	soluble	JJ
cord-321401-w4ne60fn	162	12	decoy	decoy	NN
cord-321401-w4ne60fn	162	13	receptor	receptor	NN
cord-321401-w4ne60fn	162	14	for	for	IN
cord-321401-w4ne60fn	162	15	IL-33	IL-33	NNP
cord-321401-w4ne60fn	163	1	(	(	-LRB-
cord-321401-w4ne60fn	163	2	sST2	sST2	NNP
cord-321401-w4ne60fn	163	3	)	)	-RRB-
cord-321401-w4ne60fn	163	4	by	by	IN
cord-321401-w4ne60fn	163	5	airway	airway	NN
cord-321401-w4ne60fn	163	6	epithelial	epithelial	JJ
cord-321401-w4ne60fn	163	7	cells	cell	NNS
cord-321401-w4ne60fn	163	8	,	,	,
cord-321401-w4ne60fn	163	9	which	which	WDT
cord-321401-w4ne60fn	163	10	in	in	IN
cord-321401-w4ne60fn	163	11	turn	turn	NN
cord-321401-w4ne60fn	163	12	inhibits	inhibit	VBZ
cord-321401-w4ne60fn	163	13	the	the	DT
cord-321401-w4ne60fn	163	14	actions	action	NNS
cord-321401-w4ne60fn	163	15	of	of	IN
cord-321401-w4ne60fn	163	16	the	the	DT
cord-321401-w4ne60fn	163	17	type	type	NN
cord-321401-w4ne60fn	163	18	2	2	CD
cord-321401-w4ne60fn	163	19	alarmin	alarmin	NNP
cord-321401-w4ne60fn	163	20	IL-33	IL-33	NNP
cord-321401-w4ne60fn	163	21	(	(	-LRB-
cord-321401-w4ne60fn	163	22	117	117	CD
cord-321401-w4ne60fn	163	23	)	)	-RRB-
cord-321401-w4ne60fn	163	24	.	.	.
cord-321401-w4ne60fn	164	1	Taken	take	VBN
cord-321401-w4ne60fn	164	2	together	together	RB
cord-321401-w4ne60fn	164	3	,	,	,
cord-321401-w4ne60fn	164	4	these	these	DT
cord-321401-w4ne60fn	164	5	findings	finding	NNS
cord-321401-w4ne60fn	164	6	suggest	suggest	VBP
cord-321401-w4ne60fn	164	7	that	that	IN
cord-321401-w4ne60fn	164	8	on	on	IN
cord-321401-w4ne60fn	164	9	the	the	DT
cord-321401-w4ne60fn	164	10	one	one	CD
cord-321401-w4ne60fn	164	11	hand	hand	NN
cord-321401-w4ne60fn	164	12	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	164	13	)	)	-RRB-
cord-321401-w4ne60fn	164	14	2	2	CD
cord-321401-w4ne60fn	164	15	D	d	NN
cord-321401-w4ne60fn	164	16	protects	protect	VBZ
cord-321401-w4ne60fn	164	17	against	against	IN
cord-321401-w4ne60fn	164	18	infections	infection	NNS
cord-321401-w4ne60fn	164	19	by	by	IN
cord-321401-w4ne60fn	164	20	enhancing	enhance	VBG
cord-321401-w4ne60fn	164	21	epithelial	epithelial	JJ
cord-321401-w4ne60fn	164	22	barrier	barrier	NN
cord-321401-w4ne60fn	164	23	function	function	NN
cord-321401-w4ne60fn	164	24	and	and	CC
cord-321401-w4ne60fn	164	25	production	production	NN
cord-321401-w4ne60fn	164	26	of	of	IN
cord-321401-w4ne60fn	164	27	AMPs	amp	NNS
cord-321401-w4ne60fn	164	28	,	,	,
cord-321401-w4ne60fn	164	29	and	and	CC
cord-321401-w4ne60fn	164	30	on	on	IN
cord-321401-w4ne60fn	164	31	the	the	DT
cord-321401-w4ne60fn	164	32	other	other	JJ
cord-321401-w4ne60fn	164	33	hand	hand	NN
cord-321401-w4ne60fn	164	34	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	164	35	)	)	-RRB-
cord-321401-w4ne60fn	164	36	2	2	CD
cord-321401-w4ne60fn	164	37	D	d	NN
cord-321401-w4ne60fn	164	38	induces	induce	VBZ
cord-321401-w4ne60fn	164	39	tolerance	tolerance	NN
cord-321401-w4ne60fn	164	40	and	and	CC
cord-321401-w4ne60fn	164	41	dampens	dampen	VBZ
cord-321401-w4ne60fn	164	42	proinflammatory	proinflammatory	JJ
cord-321401-w4ne60fn	164	43	responses	response	NNS
cord-321401-w4ne60fn	164	44	in	in	IN
cord-321401-w4ne60fn	164	45	various	various	JJ
cord-321401-w4ne60fn	164	46	cell	cell	NN
cord-321401-w4ne60fn	164	47	types	type	NNS
cord-321401-w4ne60fn	164	48	of	of	IN
cord-321401-w4ne60fn	164	49	the	the	DT
cord-321401-w4ne60fn	164	50	airway	airway	NN
cord-321401-w4ne60fn	164	51	mucosa	mucosa	NN
cord-321401-w4ne60fn	164	52	.	.	.
cord-321401-w4ne60fn	165	1	Thereby	thereby	RB
cord-321401-w4ne60fn	165	2	,	,	,
cord-321401-w4ne60fn	165	3	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	165	4	)	)	-RRB-
cord-321401-w4ne60fn	165	5	2	2	CD
cord-321401-w4ne60fn	165	6	D	d	NN
cord-321401-w4ne60fn	165	7	may	may	MD
cord-321401-w4ne60fn	165	8	prevent	prevent	VB
cord-321401-w4ne60fn	165	9	exaggerated	exaggerated	JJ
cord-321401-w4ne60fn	165	10	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	165	11	responses	response	NNS
cord-321401-w4ne60fn	165	12	and	and	CC
cord-321401-w4ne60fn	165	13	further	further	JJ
cord-321401-w4ne60fn	165	14	damage	damage	NN
cord-321401-w4ne60fn	165	15	to	to	IN
cord-321401-w4ne60fn	165	16	the	the	DT
cord-321401-w4ne60fn	165	17	mucosal	mucosal	JJ
cord-321401-w4ne60fn	165	18	tissue	tissue	NN
cord-321401-w4ne60fn	165	19	,	,	,
cord-321401-w4ne60fn	165	20	qualities	quality	NNS
cord-321401-w4ne60fn	165	21	that	that	WDT
cord-321401-w4ne60fn	165	22	are	be	VBP
cord-321401-w4ne60fn	165	23	very	very	RB
cord-321401-w4ne60fn	165	24	relevant	relevant	JJ
cord-321401-w4ne60fn	165	25	in	in	IN
cord-321401-w4ne60fn	165	26	the	the	DT
cord-321401-w4ne60fn	165	27	context	context	NN
cord-321401-w4ne60fn	165	28	of	of	IN
cord-321401-w4ne60fn	165	29	chronic	chronic	JJ
cord-321401-w4ne60fn	165	30	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	165	31	(	(	-LRB-
cord-321401-w4ne60fn	165	32	lung	lung	NN
cord-321401-w4ne60fn	165	33	)	)	-RRB-
cord-321401-w4ne60fn	165	34	diseases	disease	NNS
cord-321401-w4ne60fn	165	35	(	(	-LRB-
cord-321401-w4ne60fn	165	36	Figure	figure	NN
cord-321401-w4ne60fn	165	37	2	2	CD
cord-321401-w4ne60fn	165	38	)	)	-RRB-
cord-321401-w4ne60fn	165	39	.	.	.
cord-321401-w4ne60fn	166	1	COPD	COPD	NNP
cord-321401-w4ne60fn	166	2	is	be	VBZ
cord-321401-w4ne60fn	166	3	considered	consider	VBN
cord-321401-w4ne60fn	166	4	to	to	TO
cord-321401-w4ne60fn	166	5	be	be	VB
cord-321401-w4ne60fn	166	6	a	a	DT
cord-321401-w4ne60fn	166	7	disease	disease	NN
cord-321401-w4ne60fn	166	8	of	of	IN
cord-321401-w4ne60fn	166	9	accelerated	accelerated	JJ
cord-321401-w4ne60fn	166	10	aging	age	VBG
cord-321401-w4ne60fn	166	11	lungs	lung	NNS
cord-321401-w4ne60fn	166	12	,	,	,
cord-321401-w4ne60fn	166	13	underscored	underscore	VBN
cord-321401-w4ne60fn	166	14	by	by	IN
cord-321401-w4ne60fn	166	15	markers	marker	NNS
cord-321401-w4ne60fn	166	16	of	of	IN
cord-321401-w4ne60fn	166	17	aging	age	VBG
cord-321401-w4ne60fn	166	18	being	be	VBG
cord-321401-w4ne60fn	166	19	increased	increase	VBN
cord-321401-w4ne60fn	166	20	in	in	IN
cord-321401-w4ne60fn	166	21	these	these	DT
cord-321401-w4ne60fn	166	22	patients	patient	NNS
cord-321401-w4ne60fn	166	23	partly	partly	RB
cord-321401-w4ne60fn	166	24	as	as	IN
cord-321401-w4ne60fn	166	25	a	a	DT
cord-321401-w4ne60fn	166	26	result	result	NN
cord-321401-w4ne60fn	166	27	of	of	IN
cord-321401-w4ne60fn	166	28	oxidative	oxidative	JJ
cord-321401-w4ne60fn	166	29	stress	stress	NN
cord-321401-w4ne60fn	166	30	(	(	-LRB-
cord-321401-w4ne60fn	166	31	120	120	CD
cord-321401-w4ne60fn	166	32	)	)	-RRB-
cord-321401-w4ne60fn	166	33	.	.	.
cord-321401-w4ne60fn	167	1	Evidence	evidence	NN
cord-321401-w4ne60fn	167	2	that	that	IN
cord-321401-w4ne60fn	167	3	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	167	4	)	)	-RRB-
cord-321401-w4ne60fn	167	5	2	2	CD
cord-321401-w4ne60fn	167	6	D	d	NN
cord-321401-w4ne60fn	167	7	may	may	MD
cord-321401-w4ne60fn	167	8	protect	protect	VB
cord-321401-w4ne60fn	167	9	epithelial	epithelial	JJ
cord-321401-w4ne60fn	167	10	cells	cell	NNS
cord-321401-w4ne60fn	167	11	from	from	IN
cord-321401-w4ne60fn	167	12	oxidative	oxidative	JJ
cord-321401-w4ne60fn	167	13	stress	stress	NN
cord-321401-w4ne60fn	167	14	was	be	VBD
cord-321401-w4ne60fn	167	15	provided	provide	VBN
cord-321401-w4ne60fn	167	16	by	by	IN
cord-321401-w4ne60fn	167	17	Pfeffer	Pfeffer	NNP
cord-321401-w4ne60fn	167	18	et	et	NNP
cord-321401-w4ne60fn	167	19	al	al	NNP
cord-321401-w4ne60fn	167	20	.	.	.
cord-321401-w4ne60fn	168	1	who	who	WP
cord-321401-w4ne60fn	168	2	demonstrated	demonstrate	VBD
cord-321401-w4ne60fn	168	3	that	that	IN
cord-321401-w4ne60fn	168	4	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	168	5	)	)	-RRB-
cord-321401-w4ne60fn	168	6	2	2	CD
cord-321401-w4ne60fn	168	7	D	d	NN
cord-321401-w4ne60fn	168	8	increased	increase	VBN
cord-321401-w4ne60fn	168	9	expression	expression	NN
cord-321401-w4ne60fn	168	10	of	of	IN
cord-321401-w4ne60fn	168	11	the	the	DT
cord-321401-w4ne60fn	168	12	antioxidant	antioxidant	JJ
cord-321401-w4ne60fn	168	13	gene	gene	NN
cord-321401-w4ne60fn	168	14	G6PD	G6PD	NNP
cord-321401-w4ne60fn	168	15	in	in	IN
cord-321401-w4ne60fn	168	16	airway	airway	NN
cord-321401-w4ne60fn	168	17	epithelial	epithelial	JJ
cord-321401-w4ne60fn	168	18	cells	cell	NNS
cord-321401-w4ne60fn	168	19	.	.	.
cord-321401-w4ne60fn	169	1	Furthermore	furthermore	RB
cord-321401-w4ne60fn	169	2	,	,	,
cord-321401-w4ne60fn	169	3	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	169	4	)	)	-RRB-
cord-321401-w4ne60fn	169	5	2	2	CD
cord-321401-w4ne60fn	169	6	D	d	NN
cord-321401-w4ne60fn	169	7	increased	increase	VBD
cord-321401-w4ne60fn	169	8	the	the	DT
cord-321401-w4ne60fn	169	9	ratio	ratio	NN
cord-321401-w4ne60fn	169	10	of	of	IN
cord-321401-w4ne60fn	169	11	reduced	reduce	VBN
cord-321401-w4ne60fn	169	12	to	to	IN
cord-321401-w4ne60fn	169	13	oxidized	oxidize	VBN
cord-321401-w4ne60fn	169	14	glutathione	glutathione	NN
cord-321401-w4ne60fn	169	15	and	and	CC
cord-321401-w4ne60fn	169	16	decreased	decrease	VBD
cord-321401-w4ne60fn	169	17	the	the	DT
cord-321401-w4ne60fn	169	18	formation	formation	NN
cord-321401-w4ne60fn	169	19	of	of	IN
cord-321401-w4ne60fn	169	20	8-isoprostane	8-isoprostane	CD
cord-321401-w4ne60fn	169	21	after	after	IN
cord-321401-w4ne60fn	169	22	exposure	exposure	NN
cord-321401-w4ne60fn	169	23	to	to	IN
cord-321401-w4ne60fn	169	24	PM	pm	NN
cord-321401-w4ne60fn	169	25	(	(	-LRB-
cord-321401-w4ne60fn	169	26	59	59	CD
cord-321401-w4ne60fn	169	27	)	)	-RRB-
cord-321401-w4ne60fn	169	28	.	.	.
cord-321401-w4ne60fn	170	1	The	the	DT
cord-321401-w4ne60fn	170	2	induction	induction	NN
cord-321401-w4ne60fn	170	3	of	of	IN
cord-321401-w4ne60fn	170	4	klotho	klotho	NNP
cord-321401-w4ne60fn	170	5	by	by	IN
cord-321401-w4ne60fn	170	6	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	170	7	)	)	-RRB-
cord-321401-w4ne60fn	170	8	2	2	CD
cord-321401-w4ne60fn	170	9	D	d	NN
cord-321401-w4ne60fn	170	10	might	may	MD
cord-321401-w4ne60fn	170	11	be	be	VB
cord-321401-w4ne60fn	170	12	another	another	DT
cord-321401-w4ne60fn	170	13	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	170	14	)	)	-RRB-
cord-321401-w4ne60fn	170	15	2	2	CD
cord-321401-w4ne60fn	170	16	D	d	NN
cord-321401-w4ne60fn	170	17	-	-	HYPH
cord-321401-w4ne60fn	170	18	mediated	mediate	VBN
cord-321401-w4ne60fn	170	19	anti	anti	JJ
cord-321401-w4ne60fn	170	20	-	-	JJ
cord-321401-w4ne60fn	170	21	aging	aging	JJ
cord-321401-w4ne60fn	170	22	mechanism	mechanism	NN
cord-321401-w4ne60fn	170	23	(	(	-LRB-
cord-321401-w4ne60fn	170	24	121	121	CD
cord-321401-w4ne60fn	170	25	)	)	-RRB-
cord-321401-w4ne60fn	170	26	.	.	.
cord-321401-w4ne60fn	171	1	Klotho	Klotho	NNP
cord-321401-w4ne60fn	171	2	is	be	VBZ
cord-321401-w4ne60fn	171	3	an	an	DT
cord-321401-w4ne60fn	171	4	anti	anti	JJ
cord-321401-w4ne60fn	171	5	-	-	JJ
cord-321401-w4ne60fn	171	6	aging	aging	JJ
cord-321401-w4ne60fn	171	7	protein	protein	NN
cord-321401-w4ne60fn	171	8	that	that	WDT
cord-321401-w4ne60fn	171	9	is	be	VBZ
cord-321401-w4ne60fn	171	10	mainly	mainly	RB
cord-321401-w4ne60fn	171	11	expressed	express	VBN
cord-321401-w4ne60fn	171	12	in	in	IN
cord-321401-w4ne60fn	171	13	the	the	DT
cord-321401-w4ne60fn	171	14	kidney	kidney	NN
cord-321401-w4ne60fn	171	15	,	,	,
cord-321401-w4ne60fn	171	16	brain	brain	NN
cord-321401-w4ne60fn	171	17	and	and	CC
cord-321401-w4ne60fn	171	18	in	in	IN
cord-321401-w4ne60fn	171	19	the	the	DT
cord-321401-w4ne60fn	171	20	lung	lung	NN
cord-321401-w4ne60fn	171	21	by	by	IN
cord-321401-w4ne60fn	171	22	airway	airway	NN
cord-321401-w4ne60fn	171	23	epithelial	epithelial	JJ
cord-321401-w4ne60fn	171	24	cells	cell	NNS
cord-321401-w4ne60fn	171	25	and	and	CC
cord-321401-w4ne60fn	171	26	exerts	exert	VBZ
cord-321401-w4ne60fn	171	27	its	-PRON-	PRP$
cord-321401-w4ne60fn	171	28	protective	protective	JJ
cord-321401-w4ne60fn	171	29	effects	effect	NNS
cord-321401-w4ne60fn	171	30	through	through	IN
cord-321401-w4ne60fn	171	31	the	the	DT
cord-321401-w4ne60fn	171	32	inhibition	inhibition	NN
cord-321401-w4ne60fn	171	33	of	of	IN
cord-321401-w4ne60fn	171	34	inflammation	inflammation	NN
cord-321401-w4ne60fn	171	35	,	,	.
cord-321401-w4ne60fn	172	1	insulin	insulin	NN
cord-321401-w4ne60fn	172	2	/	/	SYM
cord-321401-w4ne60fn	172	3	IGF-1	IGF-1	NNP
cord-321401-w4ne60fn	172	4	signaling	signal	VBG
cord-321401-w4ne60fn	172	5	and	and	CC
cord-321401-w4ne60fn	172	6	activation	activation	NN
cord-321401-w4ne60fn	172	7	of	of	IN
cord-321401-w4ne60fn	172	8	forkhead	forkhead	NNP
cord-321401-w4ne60fn	172	9	transcription	transcription	NN
cord-321401-w4ne60fn	172	10	factor	factor	NN
cord-321401-w4ne60fn	172	11	(	(	-LRB-
cord-321401-w4ne60fn	172	12	FoxO	foxo	NN
cord-321401-w4ne60fn	172	13	)	)	-RRB-
cord-321401-w4ne60fn	172	14	signaling	signaling	NN
cord-321401-w4ne60fn	172	15	,	,	,
cord-321401-w4ne60fn	172	16	which	which	WDT
cord-321401-w4ne60fn	172	17	enables	enable	VBZ
cord-321401-w4ne60fn	172	18	removal	removal	NN
cord-321401-w4ne60fn	172	19	of	of	IN
cord-321401-w4ne60fn	172	20	reactive	reactive	JJ
cord-321401-w4ne60fn	172	21	oxygen	oxygen	NN
cord-321401-w4ne60fn	172	22	species	specie	NNS
cord-321401-w4ne60fn	172	23	(	(	-LRB-
cord-321401-w4ne60fn	172	24	ROS	ROS	NNP
cord-321401-w4ne60fn	172	25	)	)	-RRB-
cord-321401-w4ne60fn	172	26	(	(	-LRB-
cord-321401-w4ne60fn	172	27	122	122	CD
cord-321401-w4ne60fn	172	28	)	)	-RRB-
cord-321401-w4ne60fn	172	29	(	(	-LRB-
cord-321401-w4ne60fn	172	30	123	123	CD
cord-321401-w4ne60fn	172	31	)	)	-RRB-
cord-321401-w4ne60fn	172	32	(	(	-LRB-
cord-321401-w4ne60fn	172	33	124	124	CD
cord-321401-w4ne60fn	172	34	)	)	-RRB-
cord-321401-w4ne60fn	172	35	.	.	.
cord-321401-w4ne60fn	173	1	Expression	expression	NN
cord-321401-w4ne60fn	173	2	of	of	IN
cord-321401-w4ne60fn	173	3	klotho	klotho	NNP
cord-321401-w4ne60fn	173	4	is	be	VBZ
cord-321401-w4ne60fn	173	5	impaired	impair	VBN
cord-321401-w4ne60fn	173	6	in	in	IN
cord-321401-w4ne60fn	173	7	the	the	DT
cord-321401-w4ne60fn	173	8	airways	airway	NNS
cord-321401-w4ne60fn	173	9	of	of	IN
cord-321401-w4ne60fn	173	10	smokers	smoker	NNS
cord-321401-w4ne60fn	173	11	and	and	CC
cord-321401-w4ne60fn	173	12	further	further	RB
cord-321401-w4ne60fn	173	13	decreased	decrease	VBD
cord-321401-w4ne60fn	173	14	in	in	IN
cord-321401-w4ne60fn	173	15	the	the	DT
cord-321401-w4ne60fn	173	16	airways	airway	NNS
cord-321401-w4ne60fn	173	17	of	of	IN
cord-321401-w4ne60fn	173	18	COPD	COPD	NNP
cord-321401-w4ne60fn	173	19	patients	patient	NNS
cord-321401-w4ne60fn	173	20	and	and	CC
cord-321401-w4ne60fn	173	21	in	in	IN
cord-321401-w4ne60fn	173	22	cultures	culture	NNS
cord-321401-w4ne60fn	173	23	of	of	IN
cord-321401-w4ne60fn	173	24	the	the	DT
cord-321401-w4ne60fn	173	25	bronchial	bronchial	JJ
cord-321401-w4ne60fn	173	26	epithelial	epithelial	JJ
cord-321401-w4ne60fn	173	27	cell	cell	NN
cord-321401-w4ne60fn	173	28	line	line	NN
cord-321401-w4ne60fn	173	29	16HBE	16hbe	CD
cord-321401-w4ne60fn	173	30	after	after	IN
cord-321401-w4ne60fn	173	31	CSE	CSE	NNP
cord-321401-w4ne60fn	173	32	exposure	exposure	NN
cord-321401-w4ne60fn	173	33	(	(	-LRB-
cord-321401-w4ne60fn	173	34	124	124	CD
cord-321401-w4ne60fn	173	35	)	)	-RRB-
cord-321401-w4ne60fn	173	36	.	.	.
cord-321401-w4ne60fn	174	1	These	these	DT
cord-321401-w4ne60fn	174	2	studies	study	NNS
cord-321401-w4ne60fn	174	3	suggest	suggest	VBP
cord-321401-w4ne60fn	174	4	that	that	IN
cord-321401-w4ne60fn	174	5	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	174	6	)	)	-RRB-
cord-321401-w4ne60fn	174	7	2	2	CD
cord-321401-w4ne60fn	174	8	D	d	NN
cord-321401-w4ne60fn	174	9	may	may	MD
cord-321401-w4ne60fn	174	10	protect	protect	VB
cord-321401-w4ne60fn	174	11	against	against	IN
cord-321401-w4ne60fn	174	12	aging	age	VBG
cord-321401-w4ne60fn	174	13	via	via	IN
cord-321401-w4ne60fn	174	14	inhibition	inhibition	NN
cord-321401-w4ne60fn	174	15	of	of	IN
cord-321401-w4ne60fn	174	16	oxidative	oxidative	JJ
cord-321401-w4ne60fn	174	17	stress	stress	NN
cord-321401-w4ne60fn	174	18	and	and	CC
cord-321401-w4ne60fn	174	19	possibly	possibly	RB
cord-321401-w4ne60fn	174	20	via	via	IN
cord-321401-w4ne60fn	174	21	its	-PRON-	PRP$
cord-321401-w4ne60fn	174	22	ability	ability	NN
cord-321401-w4ne60fn	174	23	to	to	TO
cord-321401-w4ne60fn	174	24	restore	restore	VB
cord-321401-w4ne60fn	174	25	klotho	klotho	NN
cord-321401-w4ne60fn	174	26	expression	expression	NN
cord-321401-w4ne60fn	174	27	(	(	-LRB-
cord-321401-w4ne60fn	174	28	Figure	figure	NN
cord-321401-w4ne60fn	174	29	2	2	CD
cord-321401-w4ne60fn	174	30	)	)	-RRB-
cord-321401-w4ne60fn	174	31	.	.	.
cord-321401-w4ne60fn	175	1	However	however	RB
cord-321401-w4ne60fn	175	2	,	,	,
cord-321401-w4ne60fn	175	3	direct	direct	JJ
cord-321401-w4ne60fn	175	4	evidence	evidence	NN
cord-321401-w4ne60fn	175	5	showing	show	VBG
cord-321401-w4ne60fn	175	6	that	that	IN
cord-321401-w4ne60fn	175	7	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	175	8	)	)	-RRB-
cord-321401-w4ne60fn	175	9	2	2	CD
cord-321401-w4ne60fn	175	10	D	d	NN
cord-321401-w4ne60fn	175	11	indeed	indeed	RB
cord-321401-w4ne60fn	175	12	increases	increase	VBZ
cord-321401-w4ne60fn	175	13	expression	expression	NN
cord-321401-w4ne60fn	175	14	of	of	IN
cord-321401-w4ne60fn	175	15	klotho	klotho	NNP
cord-321401-w4ne60fn	175	16	in	in	IN
cord-321401-w4ne60fn	175	17	airway	airway	JJ
cord-321401-w4ne60fn	175	18	epithelial	epithelial	JJ
cord-321401-w4ne60fn	175	19	cells	cell	NNS
cord-321401-w4ne60fn	175	20	is	be	VBZ
cord-321401-w4ne60fn	175	21	currently	currently	RB
cord-321401-w4ne60fn	175	22	lacking	lack	VBG
cord-321401-w4ne60fn	175	23	.	.	.
cord-321401-w4ne60fn	176	1	In	in	IN
cord-321401-w4ne60fn	176	2	addition	addition	NN
cord-321401-w4ne60fn	176	3	to	to	IN
cord-321401-w4ne60fn	176	4	providing	provide	VBG
cord-321401-w4ne60fn	176	5	protection	protection	NN
cord-321401-w4ne60fn	176	6	against	against	IN
cord-321401-w4ne60fn	176	7	oxidative	oxidative	JJ
cord-321401-w4ne60fn	176	8	stress	stress	NN
cord-321401-w4ne60fn	176	9	and	and	CC
cord-321401-w4ne60fn	176	10	aging	aging	NN
cord-321401-w4ne60fn	176	11	,	,	,
cord-321401-w4ne60fn	176	12	data	datum	NNS
cord-321401-w4ne60fn	176	13	from	from	IN
cord-321401-w4ne60fn	176	14	studies	study	NNS
cord-321401-w4ne60fn	176	15	using	use	VBG
cord-321401-w4ne60fn	176	16	intestinal	intestinal	JJ
cord-321401-w4ne60fn	176	17	epithelial	epithelial	JJ
cord-321401-w4ne60fn	176	18	cells	cell	NNS
cord-321401-w4ne60fn	176	19	suggest	suggest	VBP
cord-321401-w4ne60fn	176	20	that	that	IN
cord-321401-w4ne60fn	176	21	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	176	22	)	)	-RRB-
cord-321401-w4ne60fn	176	23	2	2	CD
cord-321401-w4ne60fn	176	24	D	d	NN
cord-321401-w4ne60fn	176	25	may	may	MD
cord-321401-w4ne60fn	176	26	also	also	RB
cord-321401-w4ne60fn	176	27	promote	promote	VB
cord-321401-w4ne60fn	176	28	cellular	cellular	JJ
cord-321401-w4ne60fn	176	29	survival	survival	NN
cord-321401-w4ne60fn	176	30	via	via	IN
cord-321401-w4ne60fn	176	31	the	the	DT
cord-321401-w4ne60fn	176	32	induction	induction	NN
cord-321401-w4ne60fn	176	33	of	of	IN
cord-321401-w4ne60fn	176	34	autophagy	autophagy	NN
cord-321401-w4ne60fn	176	35	and	and	CC
cord-321401-w4ne60fn	176	36	reduction	reduction	NN
cord-321401-w4ne60fn	176	37	of	of	IN
cord-321401-w4ne60fn	176	38	apoptosis	apoptosis	NN
cord-321401-w4ne60fn	176	39	(	(	-LRB-
cord-321401-w4ne60fn	176	40	125	125	CD
cord-321401-w4ne60fn	176	41	,	,	,
cord-321401-w4ne60fn	176	42	126	126	CD
cord-321401-w4ne60fn	176	43	)	)	-RRB-
cord-321401-w4ne60fn	176	44	.	.	.
cord-321401-w4ne60fn	177	1	In	in	IN
cord-321401-w4ne60fn	177	2	chronic	chronic	JJ
cord-321401-w4ne60fn	177	3	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	177	4	lung	lung	NN
cord-321401-w4ne60fn	177	5	diseases	disease	NNS
cord-321401-w4ne60fn	177	6	,	,	,
cord-321401-w4ne60fn	177	7	aberrant	aberrant	JJ
cord-321401-w4ne60fn	177	8	activation	activation	NN
cord-321401-w4ne60fn	177	9	of	of	IN
cord-321401-w4ne60fn	177	10	autophagy	autophagy	NN
cord-321401-w4ne60fn	177	11	plays	play	VBZ
cord-321401-w4ne60fn	177	12	a	a	DT
cord-321401-w4ne60fn	177	13	role	role	NN
cord-321401-w4ne60fn	177	14	in	in	IN
cord-321401-w4ne60fn	177	15	disease	disease	NN
cord-321401-w4ne60fn	177	16	pathogenesis	pathogenesis	NN
cord-321401-w4ne60fn	177	17	(	(	-LRB-
cord-321401-w4ne60fn	177	18	127	127	CD
cord-321401-w4ne60fn	177	19	)	)	-RRB-
cord-321401-w4ne60fn	177	20	.	.	.
cord-321401-w4ne60fn	178	1	A	a	DT
cord-321401-w4ne60fn	178	2	recent	recent	JJ
cord-321401-w4ne60fn	178	3	study	study	NN
cord-321401-w4ne60fn	178	4	showed	show	VBD
cord-321401-w4ne60fn	178	5	that	that	IN
cord-321401-w4ne60fn	178	6	club	club	NN
cord-321401-w4ne60fn	178	7	cells	cell	NNS
cord-321401-w4ne60fn	178	8	and	and	CC
cord-321401-w4ne60fn	178	9	autophagy	autophagy	NN
cord-321401-w4ne60fn	178	10	-	-	HYPH
cord-321401-w4ne60fn	178	11	related	relate	VBN
cord-321401-w4ne60fn	178	12	proteins	protein	NNS
cord-321401-w4ne60fn	178	13	were	be	VBD
cord-321401-w4ne60fn	178	14	both	both	DT
cord-321401-w4ne60fn	178	15	decreased	decrease	VBN
cord-321401-w4ne60fn	178	16	in	in	IN
cord-321401-w4ne60fn	178	17	COPD	COPD	NNP
cord-321401-w4ne60fn	178	18	patients	patient	NNS
cord-321401-w4ne60fn	178	19	and	and	CC
cord-321401-w4ne60fn	178	20	that	that	IN
cord-321401-w4ne60fn	178	21	these	these	DT
cord-321401-w4ne60fn	178	22	proteins	protein	NNS
cord-321401-w4ne60fn	178	23	were	be	VBD
cord-321401-w4ne60fn	178	24	important	important	JJ
cord-321401-w4ne60fn	178	25	for	for	IN
cord-321401-w4ne60fn	178	26	club	club	NN
cord-321401-w4ne60fn	178	27	cell	cell	NN
cord-321401-w4ne60fn	178	28	structure	structure	NN
cord-321401-w4ne60fn	178	29	and	and	CC
cord-321401-w4ne60fn	178	30	function	function	NN
cord-321401-w4ne60fn	178	31	in	in	IN
cord-321401-w4ne60fn	178	32	airways	airways	NNP
cord-321401-w4ne60fn	178	33	(	(	-LRB-
cord-321401-w4ne60fn	178	34	128	128	CD
cord-321401-w4ne60fn	178	35	)	)	-RRB-
cord-321401-w4ne60fn	178	36	.	.	.
cord-321401-w4ne60fn	179	1	However	however	RB
cord-321401-w4ne60fn	179	2	,	,	,
cord-321401-w4ne60fn	179	3	the	the	DT
cord-321401-w4ne60fn	179	4	effects	effect	NNS
cord-321401-w4ne60fn	179	5	of	of	IN
cord-321401-w4ne60fn	179	6	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	179	7	)	)	-RRB-
cord-321401-w4ne60fn	179	8	2	2	CD
cord-321401-w4ne60fn	179	9	D	d	NN
cord-321401-w4ne60fn	179	10	on	on	IN
cord-321401-w4ne60fn	179	11	autophagy	autophagy	NN
cord-321401-w4ne60fn	179	12	in	in	IN
cord-321401-w4ne60fn	179	13	the	the	DT
cord-321401-w4ne60fn	179	14	airway	airway	NN
cord-321401-w4ne60fn	179	15	mucosa	mucosa	NN
cord-321401-w4ne60fn	179	16	of	of	IN
cord-321401-w4ne60fn	179	17	chronic	chronic	JJ
cord-321401-w4ne60fn	179	18	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	179	19	lung	lung	NN
cord-321401-w4ne60fn	179	20	diseases	disease	NNS
cord-321401-w4ne60fn	179	21	are	be	VBP
cord-321401-w4ne60fn	179	22	still	still	RB
cord-321401-w4ne60fn	179	23	unclear	unclear	JJ
cord-321401-w4ne60fn	179	24	and	and	CC
cord-321401-w4ne60fn	179	25	need	need	VBP
cord-321401-w4ne60fn	179	26	to	to	TO
cord-321401-w4ne60fn	179	27	be	be	VB
cord-321401-w4ne60fn	179	28	further	further	RB
cord-321401-w4ne60fn	179	29	evaluated	evaluate	VBN
cord-321401-w4ne60fn	179	30	(	(	-LRB-
cord-321401-w4ne60fn	179	31	127	127	CD
cord-321401-w4ne60fn	179	32	)	)	-RRB-
cord-321401-w4ne60fn	179	33	.	.	.
cord-321401-w4ne60fn	180	1	Clearly	clearly	RB
cord-321401-w4ne60fn	180	2	vitamin	vitamin	NN
cord-321401-w4ne60fn	180	3	D	d	NN
cord-321401-w4ne60fn	180	4	has	have	VBZ
cord-321401-w4ne60fn	180	5	pivotal	pivotal	JJ
cord-321401-w4ne60fn	180	6	actions	action	NNS
cord-321401-w4ne60fn	180	7	in	in	IN
cord-321401-w4ne60fn	180	8	host	host	NN
cord-321401-w4ne60fn	180	9	defense	defense	NN
cord-321401-w4ne60fn	180	10	that	that	WDT
cord-321401-w4ne60fn	180	11	are	be	VBP
cord-321401-w4ne60fn	180	12	relevant	relevant	JJ
cord-321401-w4ne60fn	180	13	in	in	IN
cord-321401-w4ne60fn	180	14	the	the	DT
cord-321401-w4ne60fn	180	15	context	context	NN
cord-321401-w4ne60fn	180	16	of	of	IN
cord-321401-w4ne60fn	180	17	chronic	chronic	JJ
cord-321401-w4ne60fn	180	18	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	180	19	lung	lung	NN
cord-321401-w4ne60fn	180	20	diseases	disease	NNS
cord-321401-w4ne60fn	180	21	,	,	,
cord-321401-w4ne60fn	180	22	in	in	IN
cord-321401-w4ne60fn	180	23	which	which	WDT
cord-321401-w4ne60fn	180	24	vitamin	vitamin	NN
cord-321401-w4ne60fn	180	25	D	D	NNP
cord-321401-w4ne60fn	180	26	deficiency	deficiency	NN
cord-321401-w4ne60fn	180	27	may	may	MD
cord-321401-w4ne60fn	180	28	be	be	VB
cord-321401-w4ne60fn	180	29	prevalent	prevalent	JJ
cord-321401-w4ne60fn	180	30	.	.	.
cord-321401-w4ne60fn	181	1	Strategies	strategy	NNS
cord-321401-w4ne60fn	181	2	to	to	TO
cord-321401-w4ne60fn	181	3	promote	promote	VB
cord-321401-w4ne60fn	181	4	local	local	JJ
cord-321401-w4ne60fn	181	5	levels	level	NNS
cord-321401-w4ne60fn	181	6	of	of	IN
cord-321401-w4ne60fn	181	7	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	181	8	)	)	-RRB-
cord-321401-w4ne60fn	181	9	2	2	CD
cord-321401-w4ne60fn	181	10	D	d	NN
cord-321401-w4ne60fn	181	11	or	or	CC
cord-321401-w4ne60fn	181	12	use	use	VB
cord-321401-w4ne60fn	181	13	it	-PRON-	PRP
cord-321401-w4ne60fn	181	14	as	as	IN
cord-321401-w4ne60fn	181	15	a	a	DT
cord-321401-w4ne60fn	181	16	treatment	treatment	NN
cord-321401-w4ne60fn	181	17	itself	-PRON-	PRP
cord-321401-w4ne60fn	181	18	could	could	MD
cord-321401-w4ne60fn	181	19	be	be	VB
cord-321401-w4ne60fn	181	20	therefore	therefore	RB
cord-321401-w4ne60fn	181	21	of	of	IN
cord-321401-w4ne60fn	181	22	interest	interest	NN
cord-321401-w4ne60fn	181	23	.	.	.
cord-321401-w4ne60fn	182	1	Here	here	RB
cord-321401-w4ne60fn	182	2	,	,	,
cord-321401-w4ne60fn	182	3	we	-PRON-	PRP
cord-321401-w4ne60fn	182	4	will	will	MD
cord-321401-w4ne60fn	182	5	discuss	discuss	VB
cord-321401-w4ne60fn	182	6	the	the	DT
cord-321401-w4ne60fn	182	7	latest	late	JJS
cord-321401-w4ne60fn	182	8	clinical	clinical	JJ
cord-321401-w4ne60fn	182	9	evidence	evidence	NN
cord-321401-w4ne60fn	182	10	accompanied	accompany	VBN
cord-321401-w4ne60fn	182	11	with	with	IN
cord-321401-w4ne60fn	182	12	functional	functional	JJ
cord-321401-w4ne60fn	182	13	in	in	IN
cord-321401-w4ne60fn	182	14	vitro	vitro	FW
cord-321401-w4ne60fn	182	15	and	and	CC
cord-321401-w4ne60fn	182	16	animal	animal	NN
cord-321401-w4ne60fn	182	17	studies	study	NNS
cord-321401-w4ne60fn	182	18	that	that	WDT
cord-321401-w4ne60fn	182	19	may	may	MD
cord-321401-w4ne60fn	182	20	explain	explain	VB
cord-321401-w4ne60fn	182	21	the	the	DT
cord-321401-w4ne60fn	182	22	effects	effect	NNS
cord-321401-w4ne60fn	182	23	of	of	IN
cord-321401-w4ne60fn	182	24	vitamin	vitamin	NN
cord-321401-w4ne60fn	182	25	D	d	NN
cord-321401-w4ne60fn	182	26	supplementation	supplementation	NN
cord-321401-w4ne60fn	182	27	on	on	IN
cord-321401-w4ne60fn	182	28	typical	typical	JJ
cord-321401-w4ne60fn	182	29	hallmarks	hallmark	NNS
cord-321401-w4ne60fn	182	30	of	of	IN
cord-321401-w4ne60fn	182	31	chronic	chronic	JJ
cord-321401-w4ne60fn	182	32	airway	airway	NN
cord-321401-w4ne60fn	182	33	diseases	disease	NNS
cord-321401-w4ne60fn	182	34	.	.	.
cord-321401-w4ne60fn	183	1	Currently	currently	RB
cord-321401-w4ne60fn	183	2	,	,	,
cord-321401-w4ne60fn	183	3	inhaled	inhale	VBN
cord-321401-w4ne60fn	183	4	corticosteroid	corticosteroid	NN
cord-321401-w4ne60fn	183	5	(	(	-LRB-
cord-321401-w4ne60fn	183	6	ICS)-use	ics)-use	NN
cord-321401-w4ne60fn	183	7	with	with	IN
cord-321401-w4ne60fn	183	8	or	or	CC
cord-321401-w4ne60fn	183	9	without	without	IN
cord-321401-w4ne60fn	183	10	long	long	JJ
cord-321401-w4ne60fn	183	11	acting	acting	NN
cord-321401-w4ne60fn	183	12	bronchodilators	bronchodilator	NNS
cord-321401-w4ne60fn	183	13	is	be	VBZ
cord-321401-w4ne60fn	183	14	the	the	DT
cord-321401-w4ne60fn	183	15	most	most	RBS
cord-321401-w4ne60fn	183	16	frequently	frequently	RB
cord-321401-w4ne60fn	183	17	used	use	VBN
cord-321401-w4ne60fn	183	18	treatment	treatment	NN
cord-321401-w4ne60fn	183	19	for	for	IN
cord-321401-w4ne60fn	183	20	COPD	COPD	NNP
cord-321401-w4ne60fn	183	21	and	and	CC
cord-321401-w4ne60fn	183	22	asthma	asthma	NN
cord-321401-w4ne60fn	183	23	patients	patient	NNS
cord-321401-w4ne60fn	183	24	1	1	CD
cord-321401-w4ne60fn	183	25	.	.	.
cord-321401-w4ne60fn	184	1	However	however	RB
cord-321401-w4ne60fn	184	2	,	,	,
cord-321401-w4ne60fn	184	3	the	the	DT
cord-321401-w4ne60fn	184	4	response	response	NN
cord-321401-w4ne60fn	184	5	to	to	IN
cord-321401-w4ne60fn	184	6	corticosteroids	corticosteroid	NNS
cord-321401-w4ne60fn	184	7	is	be	VBZ
cord-321401-w4ne60fn	184	8	not	not	RB
cord-321401-w4ne60fn	184	9	always	always	RB
cord-321401-w4ne60fn	184	10	effective	effective	JJ
cord-321401-w4ne60fn	184	11	in	in	IN
cord-321401-w4ne60fn	184	12	many	many	JJ
cord-321401-w4ne60fn	184	13	COPD	COPD	NNP
cord-321401-w4ne60fn	184	14	patients	patient	NNS
cord-321401-w4ne60fn	184	15	and	and	CC
cord-321401-w4ne60fn	184	16	in	in	IN
cord-321401-w4ne60fn	184	17	patients	patient	NNS
cord-321401-w4ne60fn	184	18	with	with	IN
cord-321401-w4ne60fn	184	19	steroid	steroid	NN
cord-321401-w4ne60fn	184	20	resistant	resistant	JJ
cord-321401-w4ne60fn	184	21	(	(	-LRB-
cord-321401-w4ne60fn	184	22	SR)-asthma	sr)-asthma	CD
cord-321401-w4ne60fn	184	23	(	(	-LRB-
cord-321401-w4ne60fn	184	24	129	129	CD
cord-321401-w4ne60fn	184	25	)	)	-RRB-
cord-321401-w4ne60fn	184	26	.	.	.
cord-321401-w4ne60fn	185	1	There	there	EX
cord-321401-w4ne60fn	185	2	are	be	VBP
cord-321401-w4ne60fn	185	3	several	several	JJ
cord-321401-w4ne60fn	185	4	complex	complex	JJ
cord-321401-w4ne60fn	185	5	mechanisms	mechanism	NNS
cord-321401-w4ne60fn	185	6	that	that	WDT
cord-321401-w4ne60fn	185	7	underlie	underlie	VBP
cord-321401-w4ne60fn	185	8	the	the	DT
cord-321401-w4ne60fn	185	9	resistance	resistance	NN
cord-321401-w4ne60fn	185	10	to	to	IN
cord-321401-w4ne60fn	185	11	corticosteroids	corticosteroid	NNS
cord-321401-w4ne60fn	185	12	in	in	IN
cord-321401-w4ne60fn	185	13	both	both	CC
cord-321401-w4ne60fn	185	14	COPD	COPD	NNP
cord-321401-w4ne60fn	185	15	and	and	CC
cord-321401-w4ne60fn	185	16	SR	SR	NNP
cord-321401-w4ne60fn	185	17	-	-	HYPH
cord-321401-w4ne60fn	185	18	asthma	asthma	NN
cord-321401-w4ne60fn	185	19	that	that	WDT
cord-321401-w4ne60fn	185	20	include	include	VBP
cord-321401-w4ne60fn	185	21	but	but	CC
cord-321401-w4ne60fn	185	22	are	be	VBP
cord-321401-w4ne60fn	185	23	not	not	RB
cord-321401-w4ne60fn	185	24	limited	limit	VBN
cord-321401-w4ne60fn	185	25	to	to	IN
cord-321401-w4ne60fn	185	26	genetic	genetic	JJ
cord-321401-w4ne60fn	185	27	background	background	NN
cord-321401-w4ne60fn	185	28	,	,	,
cord-321401-w4ne60fn	185	29	impaired	impair	VBN
cord-321401-w4ne60fn	185	30	glucocorticoid	glucocorticoid	NN
cord-321401-w4ne60fn	185	31	receptor	receptor	NN
cord-321401-w4ne60fn	185	32	binding	binding	NN
cord-321401-w4ne60fn	185	33	,	,	,
cord-321401-w4ne60fn	185	34	T	T	NNP
cord-321401-w4ne60fn	185	35	helper	helper	NN
cord-321401-w4ne60fn	185	36	type	type	NN
cord-321401-w4ne60fn	185	37	17	17	CD
cord-321401-w4ne60fn	185	38	cell	cell	NN
cord-321401-w4ne60fn	185	39	(	(	-LRB-
cord-321401-w4ne60fn	185	40	Th17)-inflammation	th17)-inflammation	NN
cord-321401-w4ne60fn	185	41	and	and	CC
cord-321401-w4ne60fn	185	42	oxidative	oxidative	JJ
cord-321401-w4ne60fn	185	43	stress	stress	NN
cord-321401-w4ne60fn	185	44	(	(	-LRB-
cord-321401-w4ne60fn	185	45	e.g.	e.g.	RB
cord-321401-w4ne60fn	185	46	,	,	,
cord-321401-w4ne60fn	185	47	from	from	IN
cord-321401-w4ne60fn	185	48	air	air	NN
cord-321401-w4ne60fn	185	49	pollution	pollution	NN
cord-321401-w4ne60fn	185	50	or	or	CC
cord-321401-w4ne60fn	185	51	smoking	smoking	NN
cord-321401-w4ne60fn	185	52	)	)	-RRB-
cord-321401-w4ne60fn	185	53	and	and	CC
cord-321401-w4ne60fn	185	54	decreased	decrease	VBD
cord-321401-w4ne60fn	185	55	numbers	number	NNS
cord-321401-w4ne60fn	185	56	of	of	IN
cord-321401-w4ne60fn	185	57	IL-10	IL-10	NNP
cord-321401-w4ne60fn	185	58	secreting	secrete	VBG
cord-321401-w4ne60fn	185	59	regulator	regulator	NN
cord-321401-w4ne60fn	185	60	T	T	NNP
cord-321401-w4ne60fn	185	61	cells	cell	NNS
cord-321401-w4ne60fn	185	62	(	(	-LRB-
cord-321401-w4ne60fn	185	63	Tregs	Tregs	NNP
cord-321401-w4ne60fn	185	64	)	)	-RRB-
cord-321401-w4ne60fn	185	65	,	,	,
cord-321401-w4ne60fn	185	66	which	which	WDT
cord-321401-w4ne60fn	185	67	normally	normally	RB
cord-321401-w4ne60fn	185	68	prevent	prevent	VBP
cord-321401-w4ne60fn	185	69	skewing	skew	VBG
cord-321401-w4ne60fn	185	70	toward	toward	IN
cord-321401-w4ne60fn	185	71	Th17-inflammation	th17-inflammation	NN
cord-321401-w4ne60fn	185	72	(	(	-LRB-
cord-321401-w4ne60fn	185	73	129	129	CD
cord-321401-w4ne60fn	185	74	)	)	-RRB-
cord-321401-w4ne60fn	185	75	.	.	.
cord-321401-w4ne60fn	186	1	Direct	direct	JJ
cord-321401-w4ne60fn	186	2	evidence	evidence	NN
cord-321401-w4ne60fn	186	3	of	of	IN
cord-321401-w4ne60fn	186	4	the	the	DT
cord-321401-w4ne60fn	186	5	ability	ability	NN
cord-321401-w4ne60fn	186	6	of	of	IN
cord-321401-w4ne60fn	186	7	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	186	8	)	)	-RRB-
cord-321401-w4ne60fn	186	9	2	2	CD
cord-321401-w4ne60fn	186	10	D	d	NN
cord-321401-w4ne60fn	186	11	to	to	TO
cord-321401-w4ne60fn	186	12	reverse	reverse	VB
cord-321401-w4ne60fn	186	13	SR	SR	NNP
cord-321401-w4ne60fn	186	14	was	be	VBD
cord-321401-w4ne60fn	186	15	provided	provide	VBN
cord-321401-w4ne60fn	186	16	by	by	IN
cord-321401-w4ne60fn	186	17	a	a	DT
cord-321401-w4ne60fn	186	18	study	study	NN
cord-321401-w4ne60fn	186	19	showing	show	VBG
cord-321401-w4ne60fn	186	20	that	that	IN
cord-321401-w4ne60fn	186	21	ex	ex	JJ
cord-321401-w4ne60fn	186	22	-	-	JJ
cord-321401-w4ne60fn	186	23	vivo	vivo	JJ
cord-321401-w4ne60fn	186	24	stimulation	stimulation	NN
cord-321401-w4ne60fn	186	25	1	1	CD
cord-321401-w4ne60fn	186	26	https://goldcopd.org	https://goldcopd.org	ADD
cord-321401-w4ne60fn	186	27	(	(	-LRB-
cord-321401-w4ne60fn	186	28	2019	2019	CD
cord-321401-w4ne60fn	186	29	)	)	-RRB-
cord-321401-w4ne60fn	186	30	.	.	.
cord-321401-w4ne60fn	187	1	with	with	IN
cord-321401-w4ne60fn	187	2	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	187	3	)	)	-RRB-
cord-321401-w4ne60fn	187	4	2	2	CD
cord-321401-w4ne60fn	187	5	D	d	NN
cord-321401-w4ne60fn	187	6	promoted	promote	VBN
cord-321401-w4ne60fn	187	7	generation	generation	NN
cord-321401-w4ne60fn	187	8	of	of	IN
cord-321401-w4ne60fn	187	9	IL-10-secreting	IL-10-secreting	NNP
cord-321401-w4ne60fn	187	10	Tregs	Tregs	NNP
cord-321401-w4ne60fn	187	11	which	which	WDT
cord-321401-w4ne60fn	187	12	restored	restore	VBD
cord-321401-w4ne60fn	187	13	sensitivity	sensitivity	NN
cord-321401-w4ne60fn	187	14	toward	toward	IN
cord-321401-w4ne60fn	187	15	corticosteroids	corticosteroid	NNS
cord-321401-w4ne60fn	187	16	in	in	IN
cord-321401-w4ne60fn	187	17	CD4	CD4	NNP
cord-321401-w4ne60fn	187	18	+	+	CC
cord-321401-w4ne60fn	187	19	T	t	NN
cord-321401-w4ne60fn	187	20	cells	cell	NNS
cord-321401-w4ne60fn	187	21	that	that	WDT
cord-321401-w4ne60fn	187	22	were	be	VBD
cord-321401-w4ne60fn	187	23	derived	derive	VBN
cord-321401-w4ne60fn	187	24	from	from	IN
cord-321401-w4ne60fn	187	25	SR	SR	NNP
cord-321401-w4ne60fn	187	26	-	-	HYPH
cord-321401-w4ne60fn	187	27	asthma	asthma	NN
cord-321401-w4ne60fn	187	28	patients	patient	NNS
cord-321401-w4ne60fn	187	29	(	(	-LRB-
cord-321401-w4ne60fn	187	30	130	130	CD
cord-321401-w4ne60fn	187	31	)	)	-RRB-
cord-321401-w4ne60fn	187	32	.	.	.
cord-321401-w4ne60fn	188	1	A	a	DT
cord-321401-w4ne60fn	188	2	further	further	JJ
cord-321401-w4ne60fn	188	3	potential	potential	JJ
cord-321401-w4ne60fn	188	4	treatment	treatment	NN
cord-321401-w4ne60fn	188	5	role	role	NN
cord-321401-w4ne60fn	188	6	of	of	IN
cord-321401-w4ne60fn	188	7	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	188	8	)	)	-RRB-
cord-321401-w4ne60fn	189	1	2	2	LS
cord-321401-w4ne60fn	189	2	D	d	NN
cord-321401-w4ne60fn	189	3	was	be	VBD
cord-321401-w4ne60fn	189	4	elegantly	elegantly	RB
cord-321401-w4ne60fn	189	5	illustrated	illustrate	VBN
cord-321401-w4ne60fn	189	6	by	by	IN
cord-321401-w4ne60fn	189	7	studies	study	NNS
cord-321401-w4ne60fn	189	8	that	that	WDT
cord-321401-w4ne60fn	189	9	showed	show	VBD
cord-321401-w4ne60fn	189	10	that	that	IN
cord-321401-w4ne60fn	189	11	vitamin	vitamin	NN
cord-321401-w4ne60fn	189	12	D	d	NN
cord-321401-w4ne60fn	189	13	deficiency	deficiency	NN
cord-321401-w4ne60fn	189	14	is	be	VBZ
cord-321401-w4ne60fn	189	15	associated	associate	VBN
cord-321401-w4ne60fn	189	16	with	with	IN
cord-321401-w4ne60fn	189	17	decreased	decrease	VBN
cord-321401-w4ne60fn	189	18	steroid	steroid	NN
cord-321401-w4ne60fn	189	19	responsiveness	responsiveness	NN
cord-321401-w4ne60fn	189	20	in	in	IN
cord-321401-w4ne60fn	189	21	asthmatics	asthmatic	NNS
cord-321401-w4ne60fn	189	22	and	and	CC
cord-321401-w4ne60fn	189	23	by	by	IN
cord-321401-w4ne60fn	189	24	the	the	DT
cord-321401-w4ne60fn	189	25	fact	fact	NN
cord-321401-w4ne60fn	189	26	that	that	IN
cord-321401-w4ne60fn	189	27	several	several	JJ
cord-321401-w4ne60fn	189	28	potential	potential	JJ
cord-321401-w4ne60fn	189	29	underlying	underlie	VBG
cord-321401-w4ne60fn	189	30	mechanisms	mechanism	NNS
cord-321401-w4ne60fn	189	31	of	of	IN
cord-321401-w4ne60fn	189	32	SR	SR	NNP
cord-321401-w4ne60fn	189	33	such	such	JJ
cord-321401-w4ne60fn	189	34	as	as	IN
cord-321401-w4ne60fn	189	35	oxidative	oxidative	JJ
cord-321401-w4ne60fn	189	36	stress	stress	NN
cord-321401-w4ne60fn	189	37	and	and	CC
cord-321401-w4ne60fn	189	38	Th17-mediated	th17-mediated	JJ
cord-321401-w4ne60fn	189	39	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	189	40	responses	response	NNS
cord-321401-w4ne60fn	189	41	could	could	MD
cord-321401-w4ne60fn	189	42	be	be	VB
cord-321401-w4ne60fn	189	43	reversed	reverse	VBN
cord-321401-w4ne60fn	189	44	by	by	IN
cord-321401-w4ne60fn	189	45	vitamin	vitamin	NN
cord-321401-w4ne60fn	189	46	D	d	NN
cord-321401-w4ne60fn	189	47	treatment	treatment	NN
cord-321401-w4ne60fn	189	48	(	(	-LRB-
cord-321401-w4ne60fn	189	49	59	59	CD
cord-321401-w4ne60fn	189	50	,	,	,
cord-321401-w4ne60fn	189	51	(	(	-LRB-
cord-321401-w4ne60fn	189	52	131	131	CD
cord-321401-w4ne60fn	189	53	)	)	-RRB-
cord-321401-w4ne60fn	189	54	(	(	-LRB-
cord-321401-w4ne60fn	189	55	132	132	CD
cord-321401-w4ne60fn	189	56	)	)	-RRB-
cord-321401-w4ne60fn	189	57	(	(	-LRB-
cord-321401-w4ne60fn	189	58	133	133	CD
cord-321401-w4ne60fn	189	59	)	)	-RRB-
cord-321401-w4ne60fn	189	60	(	(	-LRB-
cord-321401-w4ne60fn	189	61	134	134	CD
cord-321401-w4ne60fn	189	62	)	)	-RRB-
cord-321401-w4ne60fn	189	63	(	(	-LRB-
cord-321401-w4ne60fn	189	64	135	135	CD
cord-321401-w4ne60fn	189	65	)	)	-RRB-
cord-321401-w4ne60fn	189	66	(	(	-LRB-
cord-321401-w4ne60fn	189	67	136	136	CD
cord-321401-w4ne60fn	189	68	)	)	-RRB-
cord-321401-w4ne60fn	189	69	.	.	.
cord-321401-w4ne60fn	190	1	Interestingly	interestingly	RB
cord-321401-w4ne60fn	190	2	,	,	,
cord-321401-w4ne60fn	190	3	the	the	DT
cord-321401-w4ne60fn	190	4	corticosteroid	corticosteroid	NN
cord-321401-w4ne60fn	190	5	dexamethasone	dexamethasone	NN
cord-321401-w4ne60fn	190	6	was	be	VBD
cord-321401-w4ne60fn	190	7	shown	show	VBN
cord-321401-w4ne60fn	190	8	to	to	TO
cord-321401-w4ne60fn	190	9	increase	increase	VB
cord-321401-w4ne60fn	190	10	expression	expression	NN
cord-321401-w4ne60fn	190	11	of	of	IN
cord-321401-w4ne60fn	190	12	the	the	DT
cord-321401-w4ne60fn	190	13	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	190	14	and	and	CC
cord-321401-w4ne60fn	190	15	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	190	16	)	)	-RRB-
cord-321401-w4ne60fn	191	1	2	2	LS
cord-321401-w4ne60fn	191	2	D	d	NN
cord-321401-w4ne60fn	191	3	degrading	degrade	VBG
cord-321401-w4ne60fn	191	4	enzyme	enzyme	NN
cord-321401-w4ne60fn	191	5	CYP24A1	cyp24a1	NN
cord-321401-w4ne60fn	191	6	in	in	IN
cord-321401-w4ne60fn	191	7	renal	renal	JJ
cord-321401-w4ne60fn	191	8	cells	cell	NNS
cord-321401-w4ne60fn	191	9	and	and	CC
cord-321401-w4ne60fn	191	10	osteoblasts	osteoblast	NNS
cord-321401-w4ne60fn	191	11	(	(	-LRB-
cord-321401-w4ne60fn	191	12	137	137	CD
cord-321401-w4ne60fn	191	13	)	)	-RRB-
cord-321401-w4ne60fn	191	14	,	,	,
cord-321401-w4ne60fn	191	15	which	which	WDT
cord-321401-w4ne60fn	191	16	suggests	suggest	VBZ
cord-321401-w4ne60fn	191	17	a	a	DT
cord-321401-w4ne60fn	191	18	bidirectional	bidirectional	JJ
cord-321401-w4ne60fn	191	19	interaction	interaction	NN
cord-321401-w4ne60fn	191	20	between	between	IN
cord-321401-w4ne60fn	191	21	corticosteroids	corticosteroid	NNS
cord-321401-w4ne60fn	191	22	and	and	CC
cord-321401-w4ne60fn	191	23	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	191	24	)	)	-RRB-
cord-321401-w4ne60fn	191	25	2	2	CD
cord-321401-w4ne60fn	191	26	D	d	NN
cord-321401-w4ne60fn	191	27	and	and	CC
cord-321401-w4ne60fn	191	28	could	could	MD
cord-321401-w4ne60fn	191	29	further	far	RBR
cord-321401-w4ne60fn	191	30	limit	limit	VB
cord-321401-w4ne60fn	191	31	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	191	32	)	)	-RRB-
cord-321401-w4ne60fn	191	33	2	2	CD
cord-321401-w4ne60fn	191	34	D	d	NN
cord-321401-w4ne60fn	191	35	levels	level	NNS
cord-321401-w4ne60fn	191	36	for	for	IN
cord-321401-w4ne60fn	191	37	patients	patient	NNS
cord-321401-w4ne60fn	191	38	.	.	.
cord-321401-w4ne60fn	192	1	Additional	additional	JJ
cord-321401-w4ne60fn	192	2	research	research	NN
cord-321401-w4ne60fn	192	3	is	be	VBZ
cord-321401-w4ne60fn	192	4	needed	need	VBN
cord-321401-w4ne60fn	192	5	to	to	TO
cord-321401-w4ne60fn	192	6	determine	determine	VB
cord-321401-w4ne60fn	192	7	if	if	IN
cord-321401-w4ne60fn	192	8	vitamin	vitamin	NN
cord-321401-w4ne60fn	192	9	D	d	NN
cord-321401-w4ne60fn	192	10	may	may	MD
cord-321401-w4ne60fn	192	11	also	also	RB
cord-321401-w4ne60fn	192	12	improve	improve	VB
cord-321401-w4ne60fn	192	13	corticosteroid	corticosteroid	NN
cord-321401-w4ne60fn	192	14	responsiveness	responsiveness	NN
cord-321401-w4ne60fn	192	15	in	in	IN
cord-321401-w4ne60fn	192	16	COPD	COPD	NNP
cord-321401-w4ne60fn	192	17	.	.	.
cord-321401-w4ne60fn	193	1	Exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	193	2	are	be	VBP
cord-321401-w4ne60fn	193	3	a	a	DT
cord-321401-w4ne60fn	193	4	major	major	JJ
cord-321401-w4ne60fn	193	5	burden	burden	NN
cord-321401-w4ne60fn	193	6	for	for	IN
cord-321401-w4ne60fn	193	7	COPD	COPD	NNP
cord-321401-w4ne60fn	193	8	patients	patient	NNS
cord-321401-w4ne60fn	193	9	,	,	,
cord-321401-w4ne60fn	193	10	they	-PRON-	PRP
cord-321401-w4ne60fn	193	11	accelerate	accelerate	VBP
cord-321401-w4ne60fn	193	12	decline	decline	NN
cord-321401-w4ne60fn	193	13	in	in	IN
cord-321401-w4ne60fn	193	14	lung	lung	NN
cord-321401-w4ne60fn	193	15	function	function	NN
cord-321401-w4ne60fn	193	16	and	and	CC
cord-321401-w4ne60fn	193	17	frequently	frequently	RB
cord-321401-w4ne60fn	193	18	result	result	VB
cord-321401-w4ne60fn	193	19	into	into	IN
cord-321401-w4ne60fn	193	20	hospital	hospital	NN
cord-321401-w4ne60fn	193	21	admissions	admission	NNS
cord-321401-w4ne60fn	193	22	(	(	-LRB-
cord-321401-w4ne60fn	193	23	138	138	CD
cord-321401-w4ne60fn	193	24	,	,	,
cord-321401-w4ne60fn	193	25	139	139	CD
cord-321401-w4ne60fn	193	26	)	)	-RRB-
cord-321401-w4ne60fn	193	27	.	.	.
cord-321401-w4ne60fn	194	1	Exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	194	2	are	be	VBP
cord-321401-w4ne60fn	194	3	often	often	RB
cord-321401-w4ne60fn	194	4	triggered	trigger	VBN
cord-321401-w4ne60fn	194	5	by	by	IN
cord-321401-w4ne60fn	194	6	pollutants	pollutant	NNS
cord-321401-w4ne60fn	194	7	or	or	CC
cord-321401-w4ne60fn	194	8	by	by	IN
cord-321401-w4ne60fn	194	9	bacterial	bacterial	JJ
cord-321401-w4ne60fn	194	10	-	-	HYPH
cord-321401-w4ne60fn	194	11	and	and	CC
cord-321401-w4ne60fn	194	12	/	/	SYM
cord-321401-w4ne60fn	194	13	or	or	CC
cord-321401-w4ne60fn	194	14	viral	viral	JJ
cord-321401-w4ne60fn	194	15	infections	infection	NNS
cord-321401-w4ne60fn	194	16	(	(	-LRB-
cord-321401-w4ne60fn	194	17	82	82	CD
cord-321401-w4ne60fn	194	18	,	,	,
cord-321401-w4ne60fn	194	19	140	140	CD
cord-321401-w4ne60fn	194	20	,	,	,
cord-321401-w4ne60fn	194	21	141	141	CD
cord-321401-w4ne60fn	194	22	)	)	-RRB-
cord-321401-w4ne60fn	194	23	.	.	.
cord-321401-w4ne60fn	195	1	COPD	COPD	NNP
cord-321401-w4ne60fn	195	2	patients	patient	NNS
cord-321401-w4ne60fn	195	3	generally	generally	RB
cord-321401-w4ne60fn	195	4	have	have	VBP
cord-321401-w4ne60fn	195	5	lower	low	JJR
cord-321401-w4ne60fn	195	6	serum	serum	NN
cord-321401-w4ne60fn	195	7	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	195	8	levels	level	NNS
cord-321401-w4ne60fn	195	9	than	than	IN
cord-321401-w4ne60fn	195	10	age	age	NN
cord-321401-w4ne60fn	195	11	-	-	HYPH
cord-321401-w4ne60fn	195	12	and	and	CC
cord-321401-w4ne60fn	195	13	smoking	smoking	NN
cord-321401-w4ne60fn	195	14	-	-	HYPH
cord-321401-w4ne60fn	195	15	matched	match	VBN
cord-321401-w4ne60fn	195	16	controls	control	NNS
cord-321401-w4ne60fn	195	17	,	,	,
cord-321401-w4ne60fn	195	18	which	which	WDT
cord-321401-w4ne60fn	195	19	is	be	VBZ
cord-321401-w4ne60fn	195	20	associated	associate	VBN
cord-321401-w4ne60fn	195	21	with	with	IN
cord-321401-w4ne60fn	195	22	more	more	JJR
cord-321401-w4ne60fn	195	23	and	and	CC
cord-321401-w4ne60fn	195	24	more	more	RBR
cord-321401-w4ne60fn	195	25	severe	severe	JJ
cord-321401-w4ne60fn	195	26	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	195	27	(	(	-LRB-
cord-321401-w4ne60fn	195	28	8	8	CD
cord-321401-w4ne60fn	195	29	,	,	,
cord-321401-w4ne60fn	195	30	10	10	CD
cord-321401-w4ne60fn	195	31	)	)	-RRB-
cord-321401-w4ne60fn	195	32	.	.	.
cord-321401-w4ne60fn	196	1	Several	several	JJ
cord-321401-w4ne60fn	196	2	in	in	IN
cord-321401-w4ne60fn	196	3	vivo	vivo	NN
cord-321401-w4ne60fn	196	4	and	and	CC
cord-321401-w4ne60fn	196	5	in	in	IN
cord-321401-w4ne60fn	196	6	vitro	vitro	FW
cord-321401-w4ne60fn	196	7	studies	study	NNS
cord-321401-w4ne60fn	196	8	have	have	VBP
cord-321401-w4ne60fn	196	9	provided	provide	VBN
cord-321401-w4ne60fn	196	10	evidence	evidence	NN
cord-321401-w4ne60fn	196	11	that	that	WDT
cord-321401-w4ne60fn	196	12	explain	explain	VBP
cord-321401-w4ne60fn	196	13	the	the	DT
cord-321401-w4ne60fn	196	14	protective	protective	JJ
cord-321401-w4ne60fn	196	15	effects	effect	NNS
cord-321401-w4ne60fn	196	16	of	of	IN
cord-321401-w4ne60fn	196	17	vitamin	vitamin	NN
cord-321401-w4ne60fn	196	18	D	d	NN
cord-321401-w4ne60fn	196	19	on	on	IN
cord-321401-w4ne60fn	196	20	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	196	21	in	in	IN
cord-321401-w4ne60fn	196	22	COPD	COPD	NNP
cord-321401-w4ne60fn	196	23	patients	patient	NNS
cord-321401-w4ne60fn	196	24	and	and	CC
cord-321401-w4ne60fn	196	25	this	this	DT
cord-321401-w4ne60fn	196	26	will	will	MD
cord-321401-w4ne60fn	196	27	be	be	VB
cord-321401-w4ne60fn	196	28	discussed	discuss	VBN
cord-321401-w4ne60fn	196	29	accordingly	accordingly	RB
cord-321401-w4ne60fn	196	30	.	.	.
cord-321401-w4ne60fn	197	1	First	first	RB
cord-321401-w4ne60fn	197	2	of	of	IN
cord-321401-w4ne60fn	197	3	all	all	DT
cord-321401-w4ne60fn	197	4	,	,	,
cord-321401-w4ne60fn	197	5	Pfeffer	Pfeffer	NNP
cord-321401-w4ne60fn	197	6	et	et	NNP
cord-321401-w4ne60fn	197	7	al	al	NNP
cord-321401-w4ne60fn	197	8	.	.	NNP
cord-321401-w4ne60fn	197	9	showed	show	VBD
cord-321401-w4ne60fn	197	10	that	that	IN
cord-321401-w4ne60fn	197	11	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	197	12	and	and	CC
cord-321401-w4ne60fn	197	13	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	197	14	)	)	-RRB-
cord-321401-w4ne60fn	197	15	2	2	CD
cord-321401-w4ne60fn	197	16	D	d	NN
cord-321401-w4ne60fn	197	17	reduce	reduce	VBP
cord-321401-w4ne60fn	197	18	the	the	DT
cord-321401-w4ne60fn	197	19	production	production	NN
cord-321401-w4ne60fn	197	20	of	of	IN
cord-321401-w4ne60fn	197	21	proinflammatory	proinflammatory	JJ
cord-321401-w4ne60fn	197	22	cytokines	cytokine	NNS
cord-321401-w4ne60fn	197	23	in	in	IN
cord-321401-w4ne60fn	197	24	part	part	NN
cord-321401-w4ne60fn	197	25	via	via	IN
cord-321401-w4ne60fn	197	26	the	the	DT
cord-321401-w4ne60fn	197	27	ability	ability	NN
cord-321401-w4ne60fn	197	28	to	to	TO
cord-321401-w4ne60fn	197	29	enhance	enhance	VB
cord-321401-w4ne60fn	197	30	antioxidant	antioxidant	JJ
cord-321401-w4ne60fn	197	31	responses	response	NNS
cord-321401-w4ne60fn	197	32	in	in	IN
cord-321401-w4ne60fn	197	33	airway	airway	NN
cord-321401-w4ne60fn	197	34	epithelial	epithelial	JJ
cord-321401-w4ne60fn	197	35	cells	cell	NNS
cord-321401-w4ne60fn	197	36	that	that	WDT
cord-321401-w4ne60fn	197	37	were	be	VBD
cord-321401-w4ne60fn	197	38	exposed	expose	VBN
cord-321401-w4ne60fn	197	39	to	to	IN
cord-321401-w4ne60fn	197	40	PM	pm	NN
cord-321401-w4ne60fn	197	41	(	(	-LRB-
cord-321401-w4ne60fn	197	42	59	59	CD
cord-321401-w4ne60fn	197	43	)	)	-RRB-
cord-321401-w4ne60fn	197	44	.	.	.
cord-321401-w4ne60fn	198	1	This	this	DT
cord-321401-w4ne60fn	198	2	was	be	VBD
cord-321401-w4ne60fn	198	3	also	also	RB
cord-321401-w4ne60fn	198	4	demonstrated	demonstrate	VBN
cord-321401-w4ne60fn	198	5	in	in	IN
cord-321401-w4ne60fn	198	6	human	human	JJ
cord-321401-w4ne60fn	198	7	DCs	dc	NNS
cord-321401-w4ne60fn	198	8	that	that	WDT
cord-321401-w4ne60fn	198	9	were	be	VBD
cord-321401-w4ne60fn	198	10	matured	mature	VBN
cord-321401-w4ne60fn	198	11	in	in	IN
cord-321401-w4ne60fn	198	12	presence	presence	NN
cord-321401-w4ne60fn	198	13	of	of	IN
cord-321401-w4ne60fn	198	14	PM	PM	NNP
cord-321401-w4ne60fn	198	15	,	,	,
cord-321401-w4ne60fn	198	16	where	where	WRB
cord-321401-w4ne60fn	198	17	treatment	treatment	NN
cord-321401-w4ne60fn	198	18	with	with	IN
cord-321401-w4ne60fn	198	19	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	198	20	)	)	-RRB-
cord-321401-w4ne60fn	198	21	2	2	CD
cord-321401-w4ne60fn	198	22	D	d	NN
cord-321401-w4ne60fn	198	23	counteracted	counteract	VBD
cord-321401-w4ne60fn	198	24	the	the	DT
cord-321401-w4ne60fn	198	25	expansion	expansion	NN
cord-321401-w4ne60fn	198	26	of	of	IN
cord-321401-w4ne60fn	198	27	proinflammatory	proinflammatory	JJ
cord-321401-w4ne60fn	198	28	IL-17A	il-17a	NN
cord-321401-w4ne60fn	198	29	+	+	CC
cord-321401-w4ne60fn	198	30	and	and	CC
cord-321401-w4ne60fn	198	31	IFN	IFN	NNP
cord-321401-w4ne60fn	198	32	-	-	HYPH
cord-321401-w4ne60fn	198	33	γ	γ	NN
cord-321401-w4ne60fn	198	34	+	+	CC
cord-321401-w4ne60fn	198	35	Th17.1	th17.1	CD
cord-321401-w4ne60fn	198	36	cells	cell	NNS
cord-321401-w4ne60fn	198	37	(	(	-LRB-
cord-321401-w4ne60fn	198	38	134	134	CD
cord-321401-w4ne60fn	198	39	)	)	-RRB-
cord-321401-w4ne60fn	198	40	.	.	.
cord-321401-w4ne60fn	199	1	In	in	IN
cord-321401-w4ne60fn	199	2	line	line	NN
cord-321401-w4ne60fn	199	3	with	with	IN
cord-321401-w4ne60fn	199	4	this	this	DT
cord-321401-w4ne60fn	199	5	,	,	,
cord-321401-w4ne60fn	199	6	Bolcas	Bolcas	NNP
cord-321401-w4ne60fn	199	7	et	et	NNP
cord-321401-w4ne60fn	199	8	al	al	NNP
cord-321401-w4ne60fn	199	9	.	.	NNP
cord-321401-w4ne60fn	199	10	,	,	,
cord-321401-w4ne60fn	199	11	showed	show	VBD
cord-321401-w4ne60fn	199	12	that	that	IN
cord-321401-w4ne60fn	199	13	vitamin	vitamin	NN
cord-321401-w4ne60fn	199	14	D	D	NNP
cord-321401-w4ne60fn	199	15	supplementation	supplementation	NN
cord-321401-w4ne60fn	199	16	counteracted	counteract	VBD
cord-321401-w4ne60fn	199	17	the	the	DT
cord-321401-w4ne60fn	199	18	development	development	NN
cord-321401-w4ne60fn	199	19	of	of	IN
cord-321401-w4ne60fn	199	20	airway	airway	NNP
cord-321401-w4ne60fn	199	21	hyperresponsiveness	hyperresponsiveness	NNP
cord-321401-w4ne60fn	199	22	and	and	CC
cord-321401-w4ne60fn	199	23	accumulation	accumulation	NN
cord-321401-w4ne60fn	199	24	of	of	IN
cord-321401-w4ne60fn	199	25	Th2	Th2	NNP
cord-321401-w4ne60fn	199	26	/	/	SYM
cord-321401-w4ne60fn	199	27	Th17	Th17	NNP
cord-321401-w4ne60fn	199	28	cells	cell	NNS
cord-321401-w4ne60fn	199	29	in	in	IN
cord-321401-w4ne60fn	199	30	mice	mouse	NNS
cord-321401-w4ne60fn	199	31	that	that	WDT
cord-321401-w4ne60fn	199	32	had	have	VBD
cord-321401-w4ne60fn	199	33	been	be	VBN
cord-321401-w4ne60fn	199	34	repeatedly	repeatedly	RB
cord-321401-w4ne60fn	199	35	exposed	expose	VBN
cord-321401-w4ne60fn	199	36	to	to	IN
cord-321401-w4ne60fn	199	37	both	both	DT
cord-321401-w4ne60fn	199	38	diesel	diesel	NN
cord-321401-w4ne60fn	199	39	exhaust	exhaust	NN
cord-321401-w4ne60fn	199	40	and	and	CC
cord-321401-w4ne60fn	199	41	house	house	NN
cord-321401-w4ne60fn	199	42	dust	dust	NN
cord-321401-w4ne60fn	199	43	mite	mite	NNP
cord-321401-w4ne60fn	199	44	allergens	allergens	NNPS
cord-321401-w4ne60fn	199	45	(	(	-LRB-
cord-321401-w4ne60fn	199	46	142	142	CD
cord-321401-w4ne60fn	199	47	)	)	-RRB-
cord-321401-w4ne60fn	199	48	.	.	.
cord-321401-w4ne60fn	200	1	Vitamin	vitamin	NN
cord-321401-w4ne60fn	200	2	D	d	NN
cord-321401-w4ne60fn	200	3	could	could	MD
cord-321401-w4ne60fn	200	4	therefore	therefore	RB
cord-321401-w4ne60fn	200	5	exert	exert	VB
cord-321401-w4ne60fn	200	6	a	a	DT
cord-321401-w4ne60fn	200	7	protective	protective	JJ
cord-321401-w4ne60fn	200	8	role	role	NN
cord-321401-w4ne60fn	200	9	in	in	IN
cord-321401-w4ne60fn	200	10	air	air	NN
cord-321401-w4ne60fn	200	11	pollution	pollution	NN
cord-321401-w4ne60fn	200	12	-	-	HYPH
cord-321401-w4ne60fn	200	13	triggered	trigger	VBN
cord-321401-w4ne60fn	200	14	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	200	15	.	.	.
cord-321401-w4ne60fn	201	1	In	in	IN
cord-321401-w4ne60fn	201	2	addition	addition	NN
cord-321401-w4ne60fn	201	3	to	to	IN
cord-321401-w4ne60fn	201	4	its	-PRON-	PRP$
cord-321401-w4ne60fn	201	5	protective	protective	JJ
cord-321401-w4ne60fn	201	6	effects	effect	NNS
cord-321401-w4ne60fn	201	7	against	against	IN
cord-321401-w4ne60fn	201	8	pollutants	pollutant	NNS
cord-321401-w4ne60fn	201	9	,	,	,
cord-321401-w4ne60fn	201	10	there	there	EX
cord-321401-w4ne60fn	201	11	is	be	VBZ
cord-321401-w4ne60fn	201	12	also	also	RB
cord-321401-w4ne60fn	201	13	increasing	increase	VBG
cord-321401-w4ne60fn	201	14	evidence	evidence	NN
cord-321401-w4ne60fn	201	15	that	that	IN
cord-321401-w4ne60fn	201	16	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	201	17	)	)	-RRB-
cord-321401-w4ne60fn	201	18	2	2	CD
cord-321401-w4ne60fn	201	19	D	d	NN
cord-321401-w4ne60fn	201	20	may	may	MD
cord-321401-w4ne60fn	201	21	enhance	enhance	VB
cord-321401-w4ne60fn	201	22	clearance	clearance	NN
cord-321401-w4ne60fn	201	23	of	of	IN
cord-321401-w4ne60fn	201	24	respiratory	respiratory	JJ
cord-321401-w4ne60fn	201	25	viral	viral	JJ
cord-321401-w4ne60fn	201	26	infections	infection	NNS
cord-321401-w4ne60fn	201	27	that	that	WDT
cord-321401-w4ne60fn	201	28	account	account	VBP
cord-321401-w4ne60fn	201	29	for	for	IN
cord-321401-w4ne60fn	201	30	30	30	CD
cord-321401-w4ne60fn	201	31	-	-	SYM
cord-321401-w4ne60fn	201	32	50	50	CD
cord-321401-w4ne60fn	201	33	%	%	NN
cord-321401-w4ne60fn	201	34	as	as	IN
cord-321401-w4ne60fn	201	35	underlying	underlying	JJ
cord-321401-w4ne60fn	201	36	cause	cause	NN
cord-321401-w4ne60fn	201	37	of	of	IN
cord-321401-w4ne60fn	201	38	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	201	39	in	in	IN
cord-321401-w4ne60fn	201	40	COPD	COPD	NNP
cord-321401-w4ne60fn	201	41	patients	patient	NNS
cord-321401-w4ne60fn	201	42	(	(	-LRB-
cord-321401-w4ne60fn	201	43	143	143	CD
cord-321401-w4ne60fn	201	44	)	)	-RRB-
cord-321401-w4ne60fn	201	45	.	.	.
cord-321401-w4ne60fn	202	1	Infections	infection	NNS
cord-321401-w4ne60fn	202	2	with	with	IN
cord-321401-w4ne60fn	202	3	respiratory	respiratory	JJ
cord-321401-w4ne60fn	202	4	viruses	virus	NNS
cord-321401-w4ne60fn	202	5	such	such	JJ
cord-321401-w4ne60fn	202	6	as	as	IN
cord-321401-w4ne60fn	202	7	HRV	HRV	NNP
cord-321401-w4ne60fn	202	8	,	,	,
cord-321401-w4ne60fn	202	9	coronaviruses	coronaviruse	NNS
cord-321401-w4ne60fn	202	10	and	and	CC
cord-321401-w4ne60fn	202	11	to	to	IN
cord-321401-w4ne60fn	202	12	a	a	DT
cord-321401-w4ne60fn	202	13	lesser	less	JJR
cord-321401-w4ne60fn	202	14	extend	extend	VB
cord-321401-w4ne60fn	202	15	respiratory	respiratory	JJ
cord-321401-w4ne60fn	202	16	syncytial	syncytial	JJ
cord-321401-w4ne60fn	202	17	virus	virus	NN
cord-321401-w4ne60fn	202	18	(	(	-LRB-
cord-321401-w4ne60fn	202	19	RSV	RSV	NNP
cord-321401-w4ne60fn	202	20	)	)	-RRB-
cord-321401-w4ne60fn	202	21	and	and	CC
cord-321401-w4ne60fn	202	22	(	(	-LRB-
cord-321401-w4ne60fn	202	23	para)influenza	para)influenza	NNP
cord-321401-w4ne60fn	202	24	virus	virus	NN
cord-321401-w4ne60fn	202	25	are	be	VBP
cord-321401-w4ne60fn	202	26	present	present	JJ
cord-321401-w4ne60fn	202	27	during	during	IN
cord-321401-w4ne60fn	202	28	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	202	29	and	and	CC
cord-321401-w4ne60fn	202	30	may	may	MD
cord-321401-w4ne60fn	202	31	predispose	predispose	VB
cord-321401-w4ne60fn	202	32	the	the	DT
cord-321401-w4ne60fn	202	33	host	host	NN
cord-321401-w4ne60fn	202	34	toward	toward	IN
cord-321401-w4ne60fn	202	35	secondary	secondary	JJ
cord-321401-w4ne60fn	202	36	bacterial	bacterial	JJ
cord-321401-w4ne60fn	202	37	infections	infection	NNS
cord-321401-w4ne60fn	202	38	that	that	WDT
cord-321401-w4ne60fn	202	39	can	can	MD
cord-321401-w4ne60fn	202	40	eventually	eventually	RB
cord-321401-w4ne60fn	202	41	lead	lead	VB
cord-321401-w4ne60fn	202	42	to	to	IN
cord-321401-w4ne60fn	202	43	uncontrolled	uncontrolled	JJ
cord-321401-w4ne60fn	202	44	bacterial	bacterial	JJ
cord-321401-w4ne60fn	202	45	outgrowth	outgrowth	NN
cord-321401-w4ne60fn	202	46	,	,	,
cord-321401-w4ne60fn	202	47	more	more	RBR
cord-321401-w4ne60fn	202	48	severe	severe	JJ
cord-321401-w4ne60fn	202	49	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	202	50	and	and	CC
cord-321401-w4ne60fn	202	51	neutrophilic	neutrophilic	JJ
cord-321401-w4ne60fn	202	52	inflammation	inflammation	NN
cord-321401-w4ne60fn	202	53	(	(	-LRB-
cord-321401-w4ne60fn	202	54	143	143	CD
cord-321401-w4ne60fn	202	55	,	,	,
cord-321401-w4ne60fn	202	56	144	144	CD
cord-321401-w4ne60fn	202	57	)	)	-RRB-
cord-321401-w4ne60fn	202	58	.	.	.
cord-321401-w4ne60fn	203	1	Two	two	CD
cord-321401-w4ne60fn	203	2	recent	recent	JJ
cord-321401-w4ne60fn	203	3	in	in	IN
cord-321401-w4ne60fn	203	4	vitro	vitro	FW
cord-321401-w4ne60fn	203	5	studies	study	NNS
cord-321401-w4ne60fn	203	6	showed	show	VBD
cord-321401-w4ne60fn	203	7	that	that	IN
cord-321401-w4ne60fn	203	8	acute	acute	JJ
cord-321401-w4ne60fn	203	9	exposure	exposure	NN
cord-321401-w4ne60fn	203	10	to	to	IN
cord-321401-w4ne60fn	203	11	relatively	relatively	RB
cord-321401-w4ne60fn	203	12	high	high	JJ
cord-321401-w4ne60fn	203	13	doses	dose	NNS
cord-321401-w4ne60fn	203	14	(	(	-LRB-
cord-321401-w4ne60fn	203	15	100	100	CD
cord-321401-w4ne60fn	203	16	-	-	SYM
cord-321401-w4ne60fn	203	17	1000	1000	CD
cord-321401-w4ne60fn	203	18	nM	nM	NNP
cord-321401-w4ne60fn	203	19	)	)	-RRB-
cord-321401-w4ne60fn	203	20	of	of	IN
cord-321401-w4ne60fn	203	21	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	203	22	)	)	-RRB-
cord-321401-w4ne60fn	203	23	2	2	CD
cord-321401-w4ne60fn	203	24	D	d	NN
cord-321401-w4ne60fn	203	25	reduced	reduce	VBN
cord-321401-w4ne60fn	203	26	HRV	HRV	NNP
cord-321401-w4ne60fn	203	27	-	-	HYPH
cord-321401-w4ne60fn	203	28	infection	infection	NN
cord-321401-w4ne60fn	203	29	in	in	IN
cord-321401-w4ne60fn	203	30	undifferentiated	undifferentiated	JJ
cord-321401-w4ne60fn	203	31	cultures	culture	NNS
cord-321401-w4ne60fn	203	32	of	of	IN
cord-321401-w4ne60fn	203	33	airway	airway	NN
cord-321401-w4ne60fn	203	34	epithelial	epithelial	JJ
cord-321401-w4ne60fn	203	35	cells	cell	NNS
cord-321401-w4ne60fn	203	36	(	(	-LRB-
cord-321401-w4ne60fn	203	37	58	58	CD
cord-321401-w4ne60fn	203	38	,	,	,
cord-321401-w4ne60fn	203	39	145	145	CD
cord-321401-w4ne60fn	203	40	)	)	-RRB-
cord-321401-w4ne60fn	203	41	.	.	.
cord-321401-w4ne60fn	204	1	In	in	IN
cord-321401-w4ne60fn	204	2	those	those	DT
cord-321401-w4ne60fn	204	3	models	model	NNS
cord-321401-w4ne60fn	204	4	,	,	,
cord-321401-w4ne60fn	204	5	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	204	6	)	)	-RRB-
cord-321401-w4ne60fn	204	7	2	2	CD
cord-321401-w4ne60fn	204	8	D	D	NNP
cord-321401-w4ne60fn	204	9	most	most	RBS
cord-321401-w4ne60fn	204	10	likely	likely	RB
cord-321401-w4ne60fn	204	11	interfered	interfere	VBD
cord-321401-w4ne60fn	204	12	with	with	IN
cord-321401-w4ne60fn	204	13	viral	viral	JJ
cord-321401-w4ne60fn	204	14	replication	replication	NN
cord-321401-w4ne60fn	204	15	by	by	IN
cord-321401-w4ne60fn	204	16	increasing	increase	VBG
cord-321401-w4ne60fn	204	17	expression	expression	NN
cord-321401-w4ne60fn	204	18	of	of	IN
cord-321401-w4ne60fn	204	19	interferon	interferon	NN
cord-321401-w4ne60fn	204	20	-	-	HYPH
cord-321401-w4ne60fn	204	21	stimulated	stimulate	VBN
cord-321401-w4ne60fn	204	22	genes	gene	NNS
cord-321401-w4ne60fn	204	23	and	and	CC
cord-321401-w4ne60fn	204	24	expression	expression	NN
cord-321401-w4ne60fn	204	25	of	of	IN
cord-321401-w4ne60fn	204	26	hCAP18	hCAP18	NNP
cord-321401-w4ne60fn	204	27	/	/	SYM
cord-321401-w4ne60fn	204	28	LL-37	LL-37	NNP
cord-321401-w4ne60fn	204	29	,	,	,
cord-321401-w4ne60fn	204	30	which	which	WDT
cord-321401-w4ne60fn	204	31	has	have	VBZ
cord-321401-w4ne60fn	204	32	been	be	VBN
cord-321401-w4ne60fn	204	33	shown	show	VBN
cord-321401-w4ne60fn	204	34	to	to	TO
cord-321401-w4ne60fn	204	35	have	have	VB
cord-321401-w4ne60fn	204	36	direct	direct	JJ
cord-321401-w4ne60fn	204	37	antiviral	antiviral	JJ
cord-321401-w4ne60fn	204	38	activity	activity	NN
cord-321401-w4ne60fn	204	39	(	(	-LRB-
cord-321401-w4ne60fn	204	40	58	58	CD
cord-321401-w4ne60fn	204	41	,	,	,
cord-321401-w4ne60fn	204	42	145	145	CD
cord-321401-w4ne60fn	204	43	,	,	,
cord-321401-w4ne60fn	204	44	146	146	CD
cord-321401-w4ne60fn	204	45	)	)	-RRB-
cord-321401-w4ne60fn	204	46	.	.	.
cord-321401-w4ne60fn	205	1	In	in	IN
cord-321401-w4ne60fn	205	2	fully	fully	RB
cord-321401-w4ne60fn	205	3	differentiated	differentiate	VBN
cord-321401-w4ne60fn	205	4	airway	airway	NN
cord-321401-w4ne60fn	205	5	epithelial	epithelial	JJ
cord-321401-w4ne60fn	205	6	cells	cell	NNS
cord-321401-w4ne60fn	205	7	,	,	,
cord-321401-w4ne60fn	205	8	treatment	treatment	NN
cord-321401-w4ne60fn	205	9	with	with	IN
cord-321401-w4ne60fn	205	10	lower	low	JJR
cord-321401-w4ne60fn	205	11	concentrations	concentration	NNS
cord-321401-w4ne60fn	205	12	of	of	IN
cord-321401-w4ne60fn	205	13	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	205	14	)	)	-RRB-
cord-321401-w4ne60fn	205	15	2	2	CD
cord-321401-w4ne60fn	205	16	D	d	NN
cord-321401-w4ne60fn	205	17	(	(	-LRB-
cord-321401-w4ne60fn	205	18	10	10	CD
cord-321401-w4ne60fn	205	19	nM	nm	NN
cord-321401-w4ne60fn	205	20	)	)	-RRB-
cord-321401-w4ne60fn	205	21	during	during	IN
cord-321401-w4ne60fn	205	22	epithelial	epithelial	JJ
cord-321401-w4ne60fn	205	23	differentiation	differentiation	NN
cord-321401-w4ne60fn	205	24	had	have	VBD
cord-321401-w4ne60fn	205	25	no	no	DT
cord-321401-w4ne60fn	205	26	effect	effect	NN
cord-321401-w4ne60fn	205	27	on	on	IN
cord-321401-w4ne60fn	205	28	acute	acute	JJ
cord-321401-w4ne60fn	205	29	HRV	HRV	NNP
cord-321401-w4ne60fn	205	30	infection	infection	NN
cord-321401-w4ne60fn	205	31	(	(	-LRB-
cord-321401-w4ne60fn	205	32	147	147	CD
cord-321401-w4ne60fn	205	33	)	)	-RRB-
cord-321401-w4ne60fn	205	34	.	.	.
cord-321401-w4ne60fn	206	1	As	as	IN
cord-321401-w4ne60fn	206	2	for	for	IN
cord-321401-w4ne60fn	206	3	other	other	JJ
cord-321401-w4ne60fn	206	4	viruses	virus	NNS
cord-321401-w4ne60fn	206	5	than	than	IN
cord-321401-w4ne60fn	206	6	HRV	HRV	NNP
cord-321401-w4ne60fn	206	7	,	,	,
cord-321401-w4ne60fn	206	8	both	both	DT
cord-321401-w4ne60fn	206	9	Hansdottir	Hansdottir	NNP
cord-321401-w4ne60fn	206	10	et	et	NNP
cord-321401-w4ne60fn	206	11	al	al	NNP
cord-321401-w4ne60fn	206	12	.	.	.
cord-321401-w4ne60fn	207	1	and	and	CC
cord-321401-w4ne60fn	207	2	Telcian	Telcian	NNP
cord-321401-w4ne60fn	207	3	et	et	NNP
cord-321401-w4ne60fn	207	4	al	al	NNP
cord-321401-w4ne60fn	207	5	.	.	NNP
cord-321401-w4ne60fn	207	6	showed	show	VBD
cord-321401-w4ne60fn	207	7	that	that	IN
cord-321401-w4ne60fn	207	8	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	207	9	)	)	-RRB-
cord-321401-w4ne60fn	207	10	2	2	CD
cord-321401-w4ne60fn	207	11	D	d	NN
cord-321401-w4ne60fn	207	12	did	do	VBD
cord-321401-w4ne60fn	207	13	not	not	RB
cord-321401-w4ne60fn	207	14	decrease	decrease	VB
cord-321401-w4ne60fn	207	15	RSV	RSV	NNP
cord-321401-w4ne60fn	207	16	infection	infection	NN
cord-321401-w4ne60fn	207	17	in	in	IN
cord-321401-w4ne60fn	207	18	airway	airway	NN
cord-321401-w4ne60fn	207	19	epithelial	epithelial	JJ
cord-321401-w4ne60fn	207	20	cells	cell	NNS
cord-321401-w4ne60fn	207	21	,	,	,
cord-321401-w4ne60fn	207	22	but	but	CC
cord-321401-w4ne60fn	207	23	did	do	VBD
cord-321401-w4ne60fn	207	24	reduce	reduce	VB
cord-321401-w4ne60fn	207	25	virus	virus	NN
cord-321401-w4ne60fn	207	26	-	-	HYPH
cord-321401-w4ne60fn	207	27	induced	induce	VBN
cord-321401-w4ne60fn	207	28	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	207	29	responses	response	NNS
cord-321401-w4ne60fn	207	30	(	(	-LRB-
cord-321401-w4ne60fn	207	31	58	58	CD
cord-321401-w4ne60fn	207	32	,	,	,
cord-321401-w4ne60fn	207	33	116	116	CD
cord-321401-w4ne60fn	207	34	)	)	-RRB-
cord-321401-w4ne60fn	207	35	.	.	.
cord-321401-w4ne60fn	208	1	In	in	IN
cord-321401-w4ne60fn	208	2	addition	addition	NN
cord-321401-w4ne60fn	208	3	,	,	,
cord-321401-w4ne60fn	208	4	two	two	CD
cord-321401-w4ne60fn	208	5	other	other	JJ
cord-321401-w4ne60fn	208	6	studies	study	NNS
cord-321401-w4ne60fn	208	7	reported	report	VBN
cord-321401-w4ne60fn	208	8	in	in	IN
cord-321401-w4ne60fn	208	9	influenza	influenza	NN
cord-321401-w4ne60fn	208	10	(	(	-LRB-
cord-321401-w4ne60fn	208	11	H9N2	H9N2	NNP
cord-321401-w4ne60fn	208	12	and	and	CC
cord-321401-w4ne60fn	208	13	H1N1)-infected	H1N1)-infected	NNP
cord-321401-w4ne60fn	208	14	A549	A549	NNP
cord-321401-w4ne60fn	208	15	cells	cell	NNS
cord-321401-w4ne60fn	208	16	comparable	comparable	JJ
cord-321401-w4ne60fn	208	17	findings	finding	NNS
cord-321401-w4ne60fn	208	18	(	(	-LRB-
cord-321401-w4ne60fn	208	19	148	148	CD
cord-321401-w4ne60fn	208	20	,	,	,
cord-321401-w4ne60fn	208	21	149	149	CD
cord-321401-w4ne60fn	208	22	)	)	-RRB-
cord-321401-w4ne60fn	208	23	.	.	.
cord-321401-w4ne60fn	209	1	Moreover	moreover	RB
cord-321401-w4ne60fn	209	2	,	,	,
cord-321401-w4ne60fn	209	3	inhibitory	inhibitory	JJ
cord-321401-w4ne60fn	209	4	effects	effect	NNS
cord-321401-w4ne60fn	209	5	of	of	IN
cord-321401-w4ne60fn	209	6	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	209	7	)	)	-RRB-
cord-321401-w4ne60fn	209	8	2	2	CD
cord-321401-w4ne60fn	209	9	D	d	NN
cord-321401-w4ne60fn	209	10	on	on	IN
cord-321401-w4ne60fn	209	11	poly(I	poly(I	NNS
cord-321401-w4ne60fn	209	12	:	:	:
cord-321401-w4ne60fn	209	13	C)-induced	c)-induced	JJ
cord-321401-w4ne60fn	209	14	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	209	15	responses	response	NNS
cord-321401-w4ne60fn	209	16	were	be	VBD
cord-321401-w4ne60fn	209	17	furthermore	furthermore	RB
cord-321401-w4ne60fn	209	18	confirmed	confirm	VBN
cord-321401-w4ne60fn	209	19	in	in	IN
cord-321401-w4ne60fn	209	20	primary	primary	JJ
cord-321401-w4ne60fn	209	21	airway	airway	NN
cord-321401-w4ne60fn	209	22	epithelial	epithelial	NN
cord-321401-w4ne60fn	209	23	cells	cell	NNS
cord-321401-w4ne60fn	209	24	Hansdottir	Hansdottir	NNP
cord-321401-w4ne60fn	209	25	et	et	NNP
cord-321401-w4ne60fn	209	26	al	al	NNP
cord-321401-w4ne60fn	209	27	.	.	.
cord-321401-w4ne60fn	210	1	and	and	CC
cord-321401-w4ne60fn	210	2	by	by	IN
cord-321401-w4ne60fn	210	3	our	-PRON-	PRP$
cord-321401-w4ne60fn	210	4	group	group	NN
cord-321401-w4ne60fn	210	5	(	(	-LRB-
cord-321401-w4ne60fn	210	6	38	38	CD
cord-321401-w4ne60fn	210	7	,	,	,
cord-321401-w4ne60fn	210	8	85	85	CD
cord-321401-w4ne60fn	210	9	)	)	-RRB-
cord-321401-w4ne60fn	210	10	.	.	.
cord-321401-w4ne60fn	211	1	Up	up	IN
cord-321401-w4ne60fn	211	2	to	to	IN
cord-321401-w4ne60fn	211	3	now	now	RB
cord-321401-w4ne60fn	211	4	,	,	,
cord-321401-w4ne60fn	211	5	the	the	DT
cord-321401-w4ne60fn	211	6	afore	afore	NN
cord-321401-w4ne60fn	211	7	mentioned	mention	VBD
cord-321401-w4ne60fn	211	8	studies	study	NNS
cord-321401-w4ne60fn	211	9	suggest	suggest	VBP
cord-321401-w4ne60fn	211	10	that	that	IN
cord-321401-w4ne60fn	211	11	higher	high	JJR
cord-321401-w4ne60fn	211	12	doses	dose	NNS
cord-321401-w4ne60fn	211	13	of	of	IN
cord-321401-w4ne60fn	211	14	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	211	15	)	)	-RRB-
cord-321401-w4ne60fn	211	16	2	2	CD
cord-321401-w4ne60fn	211	17	D	d	NN
cord-321401-w4ne60fn	211	18	might	may	MD
cord-321401-w4ne60fn	211	19	be	be	VB
cord-321401-w4ne60fn	211	20	protective	protective	JJ
cord-321401-w4ne60fn	211	21	against	against	IN
cord-321401-w4ne60fn	211	22	HRV	HRV	NNP
cord-321401-w4ne60fn	211	23	-	-	HYPH
cord-321401-w4ne60fn	211	24	infections	infection	NNS
cord-321401-w4ne60fn	211	25	in	in	IN
cord-321401-w4ne60fn	211	26	undifferentiated	undifferentiated	JJ
cord-321401-w4ne60fn	211	27	airway	airway	NN
cord-321401-w4ne60fn	211	28	epithelial	epithelial	JJ
cord-321401-w4ne60fn	211	29	cells	cell	NNS
cord-321401-w4ne60fn	211	30	only	only	RB
cord-321401-w4ne60fn	211	31	,	,	,
cord-321401-w4ne60fn	211	32	whereas	whereas	IN
cord-321401-w4ne60fn	211	33	for	for	IN
cord-321401-w4ne60fn	211	34	other	other	JJ
cord-321401-w4ne60fn	211	35	respiratory	respiratory	JJ
cord-321401-w4ne60fn	211	36	viral	viral	JJ
cord-321401-w4ne60fn	211	37	infections	infection	NNS
cord-321401-w4ne60fn	211	38	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	211	39	)	)	-RRB-
cord-321401-w4ne60fn	211	40	2	2	CD
cord-321401-w4ne60fn	211	41	D	d	NN
cord-321401-w4ne60fn	211	42	mainly	mainly	RB
cord-321401-w4ne60fn	211	43	reduces	reduce	VBZ
cord-321401-w4ne60fn	211	44	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	211	45	responses	response	NNS
cord-321401-w4ne60fn	211	46	without	without	IN
cord-321401-w4ne60fn	211	47	affecting	affect	VBG
cord-321401-w4ne60fn	211	48	viral	viral	JJ
cord-321401-w4ne60fn	211	49	clearance	clearance	NN
cord-321401-w4ne60fn	211	50	.	.	.
cord-321401-w4ne60fn	212	1	However	however	RB
cord-321401-w4ne60fn	212	2	,	,	,
cord-321401-w4ne60fn	212	3	more	more	JJR
cord-321401-w4ne60fn	212	4	studies	study	NNS
cord-321401-w4ne60fn	212	5	are	be	VBP
cord-321401-w4ne60fn	212	6	needed	need	VBN
cord-321401-w4ne60fn	212	7	,	,	,
cord-321401-w4ne60fn	212	8	especially	especially	RB
cord-321401-w4ne60fn	212	9	in	in	IN
cord-321401-w4ne60fn	212	10	differentiated	differentiate	VBN
cord-321401-w4ne60fn	212	11	airway	airway	NN
cord-321401-w4ne60fn	212	12	epithelial	epithelial	JJ
cord-321401-w4ne60fn	212	13	cells	cell	NNS
cord-321401-w4ne60fn	212	14	using	use	VBG
cord-321401-w4ne60fn	212	15	multiple	multiple	JJ
cord-321401-w4ne60fn	212	16	HRV	HRV	NNP
cord-321401-w4ne60fn	212	17	-	-	HYPH
cord-321401-w4ne60fn	212	18	serotypes	serotype	NNS
cord-321401-w4ne60fn	212	19	that	that	WDT
cord-321401-w4ne60fn	212	20	use	use	VBP
cord-321401-w4ne60fn	212	21	different	different	JJ
cord-321401-w4ne60fn	212	22	receptors	receptor	NNS
cord-321401-w4ne60fn	212	23	for	for	IN
cord-321401-w4ne60fn	212	24	infection	infection	NN
cord-321401-w4ne60fn	212	25	to	to	TO
cord-321401-w4ne60fn	212	26	verify	verify	VB
cord-321401-w4ne60fn	212	27	if	if	IN
cord-321401-w4ne60fn	212	28	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	212	29	)	)	-RRB-
cord-321401-w4ne60fn	213	1	2	2	LS
cord-321401-w4ne60fn	213	2	D	d	NN
cord-321401-w4ne60fn	213	3	indeed	indeed	RB
cord-321401-w4ne60fn	213	4	is	be	VBZ
cord-321401-w4ne60fn	213	5	capable	capable	JJ
cord-321401-w4ne60fn	213	6	of	of	IN
cord-321401-w4ne60fn	213	7	promoting	promote	VBG
cord-321401-w4ne60fn	213	8	HRVclearance	hrvclearance	NN
cord-321401-w4ne60fn	213	9	.	.	.
cord-321401-w4ne60fn	214	1	There	there	EX
cord-321401-w4ne60fn	214	2	is	be	VBZ
cord-321401-w4ne60fn	214	3	more	more	JJR
cord-321401-w4ne60fn	214	4	consensus	consensus	NN
cord-321401-w4ne60fn	214	5	about	about	IN
cord-321401-w4ne60fn	214	6	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	214	7	)	)	-RRB-
cord-321401-w4ne60fn	215	1	2	2	LS
cord-321401-w4ne60fn	215	2	D	d	NN
cord-321401-w4ne60fn	215	3	reducing	reduce	VBG
cord-321401-w4ne60fn	215	4	virus	virus	NN
cord-321401-w4ne60fn	215	5	-	-	HYPH
cord-321401-w4ne60fn	215	6	induced	induce	VBN
cord-321401-w4ne60fn	215	7	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	215	8	responses	response	NNS
cord-321401-w4ne60fn	216	1	and	and	CC
cord-321401-w4ne60fn	216	2	this	this	DT
cord-321401-w4ne60fn	216	3	may	may	MD
cord-321401-w4ne60fn	216	4	certainly	certainly	RB
cord-321401-w4ne60fn	216	5	help	help	VB
cord-321401-w4ne60fn	216	6	to	to	TO
cord-321401-w4ne60fn	216	7	alleviate	alleviate	VB
cord-321401-w4ne60fn	216	8	the	the	DT
cord-321401-w4ne60fn	216	9	burden	burden	NN
cord-321401-w4ne60fn	216	10	of	of	IN
cord-321401-w4ne60fn	216	11	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	216	12	in	in	IN
cord-321401-w4ne60fn	216	13	COPD	COPD	NNP
cord-321401-w4ne60fn	216	14	(	(	-LRB-
cord-321401-w4ne60fn	216	15	38	38	CD
cord-321401-w4ne60fn	216	16	,	,	,
cord-321401-w4ne60fn	216	17	85	85	CD
cord-321401-w4ne60fn	216	18	)	)	-RRB-
cord-321401-w4ne60fn	216	19	.	.	.
cord-321401-w4ne60fn	217	1	In	in	IN
cord-321401-w4ne60fn	217	2	addition	addition	NN
cord-321401-w4ne60fn	217	3	to	to	IN
cord-321401-w4ne60fn	217	4	viral	viral	JJ
cord-321401-w4ne60fn	217	5	infections	infection	NNS
cord-321401-w4ne60fn	217	6	,	,	,
cord-321401-w4ne60fn	217	7	also	also	RB
cord-321401-w4ne60fn	217	8	bacterial	bacterial	JJ
cord-321401-w4ne60fn	217	9	infections	infection	NNS
cord-321401-w4ne60fn	217	10	are	be	VBP
cord-321401-w4ne60fn	217	11	associated	associate	VBN
cord-321401-w4ne60fn	217	12	with	with	IN
cord-321401-w4ne60fn	217	13	COPD	COPD	NNP
cord-321401-w4ne60fn	217	14	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	217	15	and	and	CC
cord-321401-w4ne60fn	217	16	account	account	VBP
cord-321401-w4ne60fn	217	17	for	for	IN
cord-321401-w4ne60fn	217	18	∼50	∼50	NNP
cord-321401-w4ne60fn	217	19	%	%	NN
cord-321401-w4ne60fn	217	20	of	of	IN
cord-321401-w4ne60fn	217	21	all	all	DT
cord-321401-w4ne60fn	217	22	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	217	23	(	(	-LRB-
cord-321401-w4ne60fn	217	24	150	150	CD
cord-321401-w4ne60fn	217	25	)	)	-RRB-
cord-321401-w4ne60fn	217	26	.	.	.
cord-321401-w4ne60fn	218	1	Due	due	IN
cord-321401-w4ne60fn	218	2	to	to	IN
cord-321401-w4ne60fn	218	3	improved	improved	JJ
cord-321401-w4ne60fn	218	4	study	study	NN
cord-321401-w4ne60fn	218	5	design	design	NN
cord-321401-w4ne60fn	218	6	and	and	CC
cord-321401-w4ne60fn	218	7	sampling	sampling	NN
cord-321401-w4ne60fn	218	8	techniques	technique	NNS
cord-321401-w4ne60fn	218	9	from	from	IN
cord-321401-w4ne60fn	218	10	the	the	DT
cord-321401-w4ne60fn	218	11	lower	low	JJR
cord-321401-w4ne60fn	218	12	airways	airway	NNS
cord-321401-w4ne60fn	218	13	using	use	VBG
cord-321401-w4ne60fn	218	14	bronchoscopy	bronchoscopy	NN
cord-321401-w4ne60fn	218	15	in	in	IN
cord-321401-w4ne60fn	218	16	recent	recent	JJ
cord-321401-w4ne60fn	218	17	decades	decade	NNS
cord-321401-w4ne60fn	218	18	,	,	,
cord-321401-w4ne60fn	218	19	the	the	DT
cord-321401-w4ne60fn	218	20	causative	causative	JJ
cord-321401-w4ne60fn	218	21	role	role	NN
cord-321401-w4ne60fn	218	22	of	of	IN
cord-321401-w4ne60fn	218	23	bacteria	bacteria	NNS
cord-321401-w4ne60fn	218	24	in	in	IN
cord-321401-w4ne60fn	218	25	COPD	COPD	NNP
cord-321401-w4ne60fn	218	26	-	-	HYPH
cord-321401-w4ne60fn	218	27	related	relate	VBN
cord-321401-w4ne60fn	218	28	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	218	29	has	have	VBZ
cord-321401-w4ne60fn	218	30	become	become	VBN
cord-321401-w4ne60fn	218	31	clear	clear	JJ
cord-321401-w4ne60fn	218	32	(	(	-LRB-
cord-321401-w4ne60fn	218	33	150	150	CD
cord-321401-w4ne60fn	218	34	)	)	-RRB-
cord-321401-w4ne60fn	218	35	.	.	.
cord-321401-w4ne60fn	219	1	This	this	DT
cord-321401-w4ne60fn	219	2	was	be	VBD
cord-321401-w4ne60fn	219	3	additionally	additionally	RB
cord-321401-w4ne60fn	219	4	supported	support	VBN
cord-321401-w4ne60fn	219	5	by	by	IN
cord-321401-w4ne60fn	219	6	Sethi	Sethi	NNP
cord-321401-w4ne60fn	219	7	et	et	NNP
cord-321401-w4ne60fn	219	8	al	al	NNP
cord-321401-w4ne60fn	219	9	.	.	NNP
cord-321401-w4ne60fn	219	10	,	,	,
cord-321401-w4ne60fn	219	11	who	who	WP
cord-321401-w4ne60fn	219	12	found	find	VBD
cord-321401-w4ne60fn	219	13	that	that	DT
cord-321401-w4ne60fn	219	14	acquisition	acquisition	NN
cord-321401-w4ne60fn	219	15	of	of	IN
cord-321401-w4ne60fn	219	16	a	a	DT
cord-321401-w4ne60fn	219	17	new	new	JJ
cord-321401-w4ne60fn	219	18	strain	strain	NN
cord-321401-w4ne60fn	219	19	of	of	IN
cord-321401-w4ne60fn	219	20	pathogenic	pathogenic	JJ
cord-321401-w4ne60fn	219	21	bacterial	bacterial	JJ
cord-321401-w4ne60fn	219	22	species	specie	NNS
cord-321401-w4ne60fn	219	23	into	into	IN
cord-321401-w4ne60fn	219	24	the	the	DT
cord-321401-w4ne60fn	219	25	airways	airway	NNS
cord-321401-w4ne60fn	219	26	was	be	VBD
cord-321401-w4ne60fn	219	27	linked	link	VBN
cord-321401-w4ne60fn	219	28	to	to	IN
cord-321401-w4ne60fn	219	29	COPD	COPD	NNP
cord-321401-w4ne60fn	219	30	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	219	31	(	(	-LRB-
cord-321401-w4ne60fn	219	32	151	151	CD
cord-321401-w4ne60fn	219	33	)	)	-RRB-
cord-321401-w4ne60fn	219	34	.	.	.
cord-321401-w4ne60fn	220	1	Recent	recent	JJ
cord-321401-w4ne60fn	220	2	developments	development	NNS
cord-321401-w4ne60fn	220	3	in	in	IN
cord-321401-w4ne60fn	220	4	assessing	assess	VBG
cord-321401-w4ne60fn	220	5	the	the	DT
cord-321401-w4ne60fn	220	6	airway	airway	NN
cord-321401-w4ne60fn	220	7	microbiota	microbiota	NN
cord-321401-w4ne60fn	220	8	using	use	VBG
cord-321401-w4ne60fn	220	9	16S	16S	NNP
cord-321401-w4ne60fn	220	10	rRNA	rrna	NN
cord-321401-w4ne60fn	220	11	sequencing	sequencing	NN
cord-321401-w4ne60fn	220	12	techniques	technique	NNS
cord-321401-w4ne60fn	220	13	further	further	RB
cord-321401-w4ne60fn	220	14	demonstrated	demonstrate	VBD
cord-321401-w4ne60fn	220	15	that	that	IN
cord-321401-w4ne60fn	220	16	during	during	IN
cord-321401-w4ne60fn	220	17	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	220	18	,	,	,
cord-321401-w4ne60fn	220	19	the	the	DT
cord-321401-w4ne60fn	220	20	relative	relative	JJ
cord-321401-w4ne60fn	220	21	abundance	abundance	NN
cord-321401-w4ne60fn	220	22	of	of	IN
cord-321401-w4ne60fn	220	23	Haemophilus	Haemophilus	NNP
cord-321401-w4ne60fn	220	24	,	,	,
cord-321401-w4ne60fn	220	25	Pseudomonas	Pseudomonas	NNP
cord-321401-w4ne60fn	220	26	,	,	,
cord-321401-w4ne60fn	220	27	and	and	CC
cord-321401-w4ne60fn	220	28	Moraxella	Moraxella	NNP
cord-321401-w4ne60fn	220	29	was	be	VBD
cord-321401-w4ne60fn	220	30	increased	increase	VBN
cord-321401-w4ne60fn	220	31	and	and	CC
cord-321401-w4ne60fn	220	32	the	the	DT
cord-321401-w4ne60fn	220	33	microbial	microbial	JJ
cord-321401-w4ne60fn	220	34	composition	composition	NN
cord-321401-w4ne60fn	220	35	was	be	VBD
cord-321401-w4ne60fn	220	36	shifted	shift	VBN
cord-321401-w4ne60fn	220	37	toward	toward	IN
cord-321401-w4ne60fn	220	38	the	the	DT
cord-321401-w4ne60fn	220	39	Proteobacteria	Proteobacteria	NNP
cord-321401-w4ne60fn	220	40	phylum	phylum	NN
cord-321401-w4ne60fn	220	41	(	(	-LRB-
cord-321401-w4ne60fn	220	42	141	141	CD
cord-321401-w4ne60fn	220	43	)	)	-RRB-
cord-321401-w4ne60fn	220	44	.	.	.
cord-321401-w4ne60fn	221	1	The	the	DT
cord-321401-w4ne60fn	221	2	ability	ability	NN
cord-321401-w4ne60fn	221	3	of	of	IN
cord-321401-w4ne60fn	221	4	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	221	5	)	)	-RRB-
cord-321401-w4ne60fn	221	6	2	2	CD
cord-321401-w4ne60fn	221	7	D	d	NN
cord-321401-w4ne60fn	221	8	to	to	TO
cord-321401-w4ne60fn	221	9	promote	promote	VB
cord-321401-w4ne60fn	221	10	antibacterial	antibacterial	JJ
cord-321401-w4ne60fn	221	11	activity	activity	NN
cord-321401-w4ne60fn	221	12	was	be	VBD
cord-321401-w4ne60fn	221	13	recently	recently	RB
cord-321401-w4ne60fn	221	14	demonstrated	demonstrate	VBN
cord-321401-w4ne60fn	221	15	in	in	IN
cord-321401-w4ne60fn	221	16	cultures	culture	NNS
cord-321401-w4ne60fn	221	17	of	of	IN
cord-321401-w4ne60fn	221	18	airway	airway	NN
cord-321401-w4ne60fn	221	19	epithelial	epithelial	JJ
cord-321401-w4ne60fn	221	20	cells	cell	NNS
cord-321401-w4ne60fn	221	21	.	.	.
cord-321401-w4ne60fn	222	1	In	in	IN
cord-321401-w4ne60fn	222	2	differentiated	differentiated	JJ
cord-321401-w4ne60fn	222	3	airway	airway	NN
cord-321401-w4ne60fn	222	4	epithelial	epithelial	JJ
cord-321401-w4ne60fn	222	5	cells	cell	NNS
cord-321401-w4ne60fn	222	6	,	,	,
cord-321401-w4ne60fn	222	7	we	-PRON-	PRP
cord-321401-w4ne60fn	222	8	have	have	VBP
cord-321401-w4ne60fn	222	9	shown	show	VBN
cord-321401-w4ne60fn	222	10	that	that	IN
cord-321401-w4ne60fn	222	11	both	both	DT
cord-321401-w4ne60fn	222	12	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	222	13	and	and	CC
cord-321401-w4ne60fn	222	14	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	222	15	)	)	-RRB-
cord-321401-w4ne60fn	222	16	2	2	CD
cord-321401-w4ne60fn	222	17	D	d	NN
cord-321401-w4ne60fn	222	18	treatment	treatment	NN
cord-321401-w4ne60fn	222	19	enhances	enhance	VBZ
cord-321401-w4ne60fn	222	20	epithelial	epithelial	JJ
cord-321401-w4ne60fn	222	21	expression	expression	NN
cord-321401-w4ne60fn	222	22	of	of	IN
cord-321401-w4ne60fn	222	23	hCAP18	hCAP18	NNP
cord-321401-w4ne60fn	222	24	/	/	SYM
cord-321401-w4ne60fn	222	25	LL-37	LL-37	NNP
cord-321401-w4ne60fn	222	26	and	and	CC
cord-321401-w4ne60fn	222	27	antibacterial	antibacterial	JJ
cord-321401-w4ne60fn	222	28	activity	activity	NN
cord-321401-w4ne60fn	222	29	against	against	IN
cord-321401-w4ne60fn	222	30	NTHi	NTHi	NNS
cord-321401-w4ne60fn	222	31	,	,	,
cord-321401-w4ne60fn	222	32	a	a	DT
cord-321401-w4ne60fn	222	33	Gram	gram	NN
cord-321401-w4ne60fn	222	34	-	-	HYPH
cord-321401-w4ne60fn	222	35	negative	negative	JJ
cord-321401-w4ne60fn	222	36	bacterium	bacterium	NN
cord-321401-w4ne60fn	222	37	,	,	,
cord-321401-w4ne60fn	222	38	which	which	WDT
cord-321401-w4ne60fn	222	39	is	be	VBZ
cord-321401-w4ne60fn	222	40	associated	associate	VBN
cord-321401-w4ne60fn	222	41	with	with	IN
cord-321401-w4ne60fn	222	42	COPD	COPD	NNP
cord-321401-w4ne60fn	222	43	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	222	44	(	(	-LRB-
cord-321401-w4ne60fn	222	45	61	61	CD
cord-321401-w4ne60fn	222	46	,	,	,
cord-321401-w4ne60fn	222	47	152	152	CD
cord-321401-w4ne60fn	222	48	)	)	-RRB-
cord-321401-w4ne60fn	222	49	.	.	.
cord-321401-w4ne60fn	223	1	In	in	IN
cord-321401-w4ne60fn	223	2	addition	addition	NN
cord-321401-w4ne60fn	223	3	,	,	,
cord-321401-w4ne60fn	223	4	Yim	Yim	NNP
cord-321401-w4ne60fn	223	5	et	et	NNP
cord-321401-w4ne60fn	223	6	al	al	NNP
cord-321401-w4ne60fn	223	7	.	.	NNP
cord-321401-w4ne60fn	223	8	demonstrated	demonstrate	VBD
cord-321401-w4ne60fn	223	9	that	that	IN
cord-321401-w4ne60fn	223	10	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	223	11	)	)	-RRB-
cord-321401-w4ne60fn	223	12	2	2	CD
cord-321401-w4ne60fn	223	13	D	d	NN
cord-321401-w4ne60fn	223	14	treatment	treatment	NN
cord-321401-w4ne60fn	223	15	increased	increase	VBN
cord-321401-w4ne60fn	223	16	expression	expression	NN
cord-321401-w4ne60fn	223	17	of	of	IN
cord-321401-w4ne60fn	223	18	the	the	DT
cord-321401-w4ne60fn	223	19	AMP	AMP	NNP
cord-321401-w4ne60fn	223	20	hCAP18	hCAP18	NNP
cord-321401-w4ne60fn	223	21	/	/	SYM
cord-321401-w4ne60fn	223	22	LL-37	LL-37	NNP
cord-321401-w4ne60fn	223	23	and	and	CC
cord-321401-w4ne60fn	223	24	killing	killing	NN
cord-321401-w4ne60fn	223	25	of	of	IN
cord-321401-w4ne60fn	223	26	Pseudomonas	Pseudomonas	NNP
cord-321401-w4ne60fn	223	27	aeruginosa	aeruginosa	NN
cord-321401-w4ne60fn	223	28	and	and	CC
cord-321401-w4ne60fn	223	29	Bordetella	Bordetella	NNP
cord-321401-w4ne60fn	223	30	bronchiseptica	bronchiseptica	NNP
cord-321401-w4ne60fn	223	31	,	,	,
cord-321401-w4ne60fn	223	32	which	which	WDT
cord-321401-w4ne60fn	223	33	are	be	VBP
cord-321401-w4ne60fn	223	34	both	both	DT
cord-321401-w4ne60fn	223	35	Gram	gram	NN
cord-321401-w4ne60fn	223	36	-	-	HYPH
cord-321401-w4ne60fn	223	37	negative	negative	JJ
cord-321401-w4ne60fn	223	38	bacteria	bacteria	NNS
cord-321401-w4ne60fn	223	39	(	(	-LRB-
cord-321401-w4ne60fn	223	40	153	153	CD
cord-321401-w4ne60fn	223	41	)	)	-RRB-
cord-321401-w4ne60fn	223	42	.	.	.
cord-321401-w4ne60fn	224	1	These	these	DT
cord-321401-w4ne60fn	224	2	observed	observe	VBD
cord-321401-w4ne60fn	224	3	antibacterial	antibacterial	JJ
cord-321401-w4ne60fn	224	4	effects	effect	NNS
cord-321401-w4ne60fn	224	5	of	of	IN
cord-321401-w4ne60fn	224	6	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	224	7	)	)	-RRB-
cord-321401-w4ne60fn	224	8	2	2	CD
cord-321401-w4ne60fn	224	9	D	d	NN
cord-321401-w4ne60fn	224	10	on	on	IN
cord-321401-w4ne60fn	224	11	airway	airway	NN
cord-321401-w4ne60fn	224	12	epithelium	epithelium	NN
cord-321401-w4ne60fn	224	13	in	in	IN
cord-321401-w4ne60fn	224	14	vitro	vitro	FW
cord-321401-w4ne60fn	224	15	were	be	VBD
cord-321401-w4ne60fn	224	16	recently	recently	RB
cord-321401-w4ne60fn	224	17	confirmed	confirm	VBN
cord-321401-w4ne60fn	224	18	in	in	IN
cord-321401-w4ne60fn	224	19	vivo	vivo	NN
cord-321401-w4ne60fn	224	20	by	by	IN
cord-321401-w4ne60fn	224	21	Vargas	Vargas	NNP
cord-321401-w4ne60fn	224	22	Buonfiglio	Buonfiglio	NNP
cord-321401-w4ne60fn	224	23	et	et	NNP
cord-321401-w4ne60fn	224	24	al	al	NNP
cord-321401-w4ne60fn	224	25	.	.	.
cord-321401-w4ne60fn	225	1	The	the	DT
cord-321401-w4ne60fn	225	2	authors	author	NNS
cord-321401-w4ne60fn	225	3	demonstrated	demonstrate	VBD
cord-321401-w4ne60fn	225	4	that	that	IN
cord-321401-w4ne60fn	225	5	vitamin	vitamin	NN
cord-321401-w4ne60fn	225	6	D	D	NNP
cord-321401-w4ne60fn	225	7	supplementation	supplementation	NN
cord-321401-w4ne60fn	225	8	increased	increase	VBD
cord-321401-w4ne60fn	225	9	antimicrobial	antimicrobial	JJ
cord-321401-w4ne60fn	225	10	activity	activity	NN
cord-321401-w4ne60fn	225	11	against	against	IN
cord-321401-w4ne60fn	225	12	the	the	DT
cord-321401-w4ne60fn	225	13	Gram	Gram	NNP
cord-321401-w4ne60fn	225	14	-	-	HYPH
cord-321401-w4ne60fn	225	15	positive	positive	JJ
cord-321401-w4ne60fn	225	16	Staphylococcus	Staphylococcus	NNP
cord-321401-w4ne60fn	225	17	aureus	aureus	NN
cord-321401-w4ne60fn	225	18	in	in	IN
cord-321401-w4ne60fn	225	19	ASL	ASL	NNP
cord-321401-w4ne60fn	225	20	in	in	IN
cord-321401-w4ne60fn	225	21	healthy	healthy	JJ
cord-321401-w4ne60fn	225	22	non	non	NNS
cord-321401-w4ne60fn	225	23	-	-	NNS
cord-321401-w4ne60fn	225	24	smokers	smoker	NNS
cord-321401-w4ne60fn	225	25	and	and	CC
cord-321401-w4ne60fn	225	26	was	be	VBD
cord-321401-w4ne60fn	225	27	dependent	dependent	JJ
cord-321401-w4ne60fn	225	28	on	on	IN
cord-321401-w4ne60fn	225	29	presence	presence	NN
cord-321401-w4ne60fn	225	30	of	of	IN
cord-321401-w4ne60fn	225	31	hCAP18	hCAP18	NNP
cord-321401-w4ne60fn	225	32	/	/	SYM
cord-321401-w4ne60fn	225	33	LL-37	LL-37	NNP
cord-321401-w4ne60fn	225	34	(	(	-LRB-
cord-321401-w4ne60fn	225	35	64	64	CD
cord-321401-w4ne60fn	225	36	)	)	-RRB-
cord-321401-w4ne60fn	225	37	.	.	.
cord-321401-w4ne60fn	226	1	In	in	IN
cord-321401-w4ne60fn	226	2	murine	murine	JJ
cord-321401-w4ne60fn	226	3	airways	airway	NNS
cord-321401-w4ne60fn	226	4	,	,	,
cord-321401-w4ne60fn	226	5	studies	study	NNS
cord-321401-w4ne60fn	226	6	showed	show	VBD
cord-321401-w4ne60fn	226	7	no	no	DT
cord-321401-w4ne60fn	226	8	effects	effect	NNS
cord-321401-w4ne60fn	226	9	of	of	IN
cord-321401-w4ne60fn	226	10	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	226	11	)	)	-RRB-
cord-321401-w4ne60fn	226	12	2	2	CD
cord-321401-w4ne60fn	226	13	D	d	NN
cord-321401-w4ne60fn	226	14	on	on	IN
cord-321401-w4ne60fn	226	15	the	the	DT
cord-321401-w4ne60fn	226	16	expression	expression	NN
cord-321401-w4ne60fn	226	17	of	of	IN
cord-321401-w4ne60fn	226	18	Defb4	Defb4	NNS
cord-321401-w4ne60fn	226	19	or	or	CC
cord-321401-w4ne60fn	226	20	mCramp	mCramp	NNP
cord-321401-w4ne60fn	226	21	(	(	-LRB-
cord-321401-w4ne60fn	226	22	the	the	DT
cord-321401-w4ne60fn	226	23	murine	murine	JJ
cord-321401-w4ne60fn	226	24	homolog	homolog	NN
cord-321401-w4ne60fn	226	25	for	for	IN
cord-321401-w4ne60fn	226	26	CAMP	camp	NN
cord-321401-w4ne60fn	226	27	)	)	-RRB-
cord-321401-w4ne60fn	226	28	(	(	-LRB-
cord-321401-w4ne60fn	226	29	154	154	CD
cord-321401-w4ne60fn	226	30	)	)	-RRB-
cord-321401-w4ne60fn	226	31	.	.	.
cord-321401-w4ne60fn	227	1	This	this	DT
cord-321401-w4ne60fn	227	2	can	can	MD
cord-321401-w4ne60fn	227	3	be	be	VB
cord-321401-w4ne60fn	227	4	explained	explain	VBN
cord-321401-w4ne60fn	227	5	by	by	IN
cord-321401-w4ne60fn	227	6	the	the	DT
cord-321401-w4ne60fn	227	7	fact	fact	NN
cord-321401-w4ne60fn	227	8	that	that	IN
cord-321401-w4ne60fn	227	9	both	both	CC
cord-321401-w4ne60fn	227	10	the	the	DT
cord-321401-w4ne60fn	227	11	promotors	promotor	NNS
cord-321401-w4ne60fn	227	12	of	of	IN
cord-321401-w4ne60fn	227	13	mCramp	mCramp	NNP
cord-321401-w4ne60fn	227	14	and	and	CC
cord-321401-w4ne60fn	227	15	Defb4	Defb4	NNP
cord-321401-w4ne60fn	227	16	lack	lack	NN
cord-321401-w4ne60fn	227	17	VDREs	VDREs	NNP
cord-321401-w4ne60fn	227	18	,	,	,
cord-321401-w4ne60fn	227	19	suggesting	suggest	VBG
cord-321401-w4ne60fn	227	20	that	that	IN
cord-321401-w4ne60fn	227	21	mice	mouse	NNS
cord-321401-w4ne60fn	227	22	might	may	MD
cord-321401-w4ne60fn	227	23	not	not	RB
cord-321401-w4ne60fn	227	24	be	be	VB
cord-321401-w4ne60fn	227	25	suitable	suitable	JJ
cord-321401-w4ne60fn	227	26	for	for	IN
cord-321401-w4ne60fn	227	27	studying	study	VBG
cord-321401-w4ne60fn	227	28	the	the	DT
cord-321401-w4ne60fn	227	29	role	role	NN
cord-321401-w4ne60fn	227	30	of	of	IN
cord-321401-w4ne60fn	227	31	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	227	32	)	)	-RRB-
cord-321401-w4ne60fn	227	33	2	2	CD
cord-321401-w4ne60fn	227	34	D	d	NN
cord-321401-w4ne60fn	227	35	in	in	IN
cord-321401-w4ne60fn	227	36	AMP	amp	NN
cord-321401-w4ne60fn	227	37	-	-	HYPH
cord-321401-w4ne60fn	227	38	mediated	mediate	VBN
cord-321401-w4ne60fn	227	39	host	host	NN
cord-321401-w4ne60fn	227	40	defense	defense	NN
cord-321401-w4ne60fn	227	41	in	in	IN
cord-321401-w4ne60fn	227	42	infection	infection	NN
cord-321401-w4ne60fn	227	43	(	(	-LRB-
cord-321401-w4ne60fn	227	44	155	155	CD
cord-321401-w4ne60fn	227	45	)	)	-RRB-
cord-321401-w4ne60fn	227	46	.	.	.
cord-321401-w4ne60fn	228	1	Indeed	indeed	RB
cord-321401-w4ne60fn	228	2	,	,	,
cord-321401-w4ne60fn	228	3	Niederstrasser	Niederstrasser	NNP
cord-321401-w4ne60fn	228	4	et	et	NNP
cord-321401-w4ne60fn	228	5	al	al	NNP
cord-321401-w4ne60fn	228	6	.	.	.
cord-321401-w4ne60fn	229	1	showed	show	VBD
cord-321401-w4ne60fn	229	2	no	no	DT
cord-321401-w4ne60fn	229	3	effects	effect	NNS
cord-321401-w4ne60fn	229	4	of	of	IN
cord-321401-w4ne60fn	229	5	vitamin	vitamin	NN
cord-321401-w4ne60fn	229	6	D	d	NN
cord-321401-w4ne60fn	229	7	deficiency	deficiency	NN
cord-321401-w4ne60fn	229	8	on	on	IN
cord-321401-w4ne60fn	229	9	the	the	DT
cord-321401-w4ne60fn	229	10	susceptibility	susceptibility	NN
cord-321401-w4ne60fn	229	11	of	of	IN
cord-321401-w4ne60fn	229	12	mice	mouse	NNS
cord-321401-w4ne60fn	229	13	to	to	IN
cord-321401-w4ne60fn	229	14	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	229	15	infection	infection	NN
cord-321401-w4ne60fn	229	16	with	with	IN
cord-321401-w4ne60fn	229	17	Streptococcus	streptococcus	NN
cord-321401-w4ne60fn	229	18	pneumoniae	pneumoniae	NN
cord-321401-w4ne60fn	229	19	or	or	CC
cord-321401-w4ne60fn	229	20	Pseudomonas	Pseudomonas	NNP
cord-321401-w4ne60fn	229	21	aeruginosa	aeruginosa	NN
cord-321401-w4ne60fn	229	22	(	(	-LRB-
cord-321401-w4ne60fn	229	23	156	156	CD
cord-321401-w4ne60fn	229	24	)	)	-RRB-
cord-321401-w4ne60fn	229	25	.	.	.
cord-321401-w4ne60fn	230	1	However	however	RB
cord-321401-w4ne60fn	230	2	,	,	,
cord-321401-w4ne60fn	230	3	in	in	IN
cord-321401-w4ne60fn	230	4	a	a	DT
cord-321401-w4ne60fn	230	5	recently	recently	RB
cord-321401-w4ne60fn	230	6	developed	develop	VBN
cord-321401-w4ne60fn	230	7	mouse	mouse	NN
cord-321401-w4ne60fn	230	8	model	model	NN
cord-321401-w4ne60fn	230	9	by	by	IN
cord-321401-w4ne60fn	230	10	Lowry	Lowry	NNP
cord-321401-w4ne60fn	230	11	et	et	NNP
cord-321401-w4ne60fn	230	12	al	al	NNP
cord-321401-w4ne60fn	230	13	.	.	NNP
cord-321401-w4ne60fn	230	14	,	,	,
cord-321401-w4ne60fn	230	15	who	who	WP
cord-321401-w4ne60fn	230	16	transfected	transfecte	VBD
cord-321401-w4ne60fn	230	17	mCramp	mCramp	NNP
cord-321401-w4ne60fn	230	18	knockout	knockout	NN
cord-321401-w4ne60fn	230	19	mice	mouse	NNS
cord-321401-w4ne60fn	230	20	with	with	IN
cord-321401-w4ne60fn	230	21	the	the	DT
cord-321401-w4ne60fn	230	22	human	human	JJ
cord-321401-w4ne60fn	230	23	CAMP	CAMP	NNP
cord-321401-w4ne60fn	230	24	gene	gene	NN
cord-321401-w4ne60fn	230	25	,	,	,
cord-321401-w4ne60fn	230	26	topical	topical	JJ
cord-321401-w4ne60fn	230	27	vitamin	vitamin	NN
cord-321401-w4ne60fn	230	28	D	d	NN
cord-321401-w4ne60fn	230	29	3	3	CD
cord-321401-w4ne60fn	230	30	treatment	treatment	NN
cord-321401-w4ne60fn	230	31	increased	increase	VBN
cord-321401-w4ne60fn	230	32	expression	expression	NN
cord-321401-w4ne60fn	230	33	of	of	IN
cord-321401-w4ne60fn	230	34	CAMP	camp	NN
cord-321401-w4ne60fn	230	35	and	and	CC
cord-321401-w4ne60fn	230	36	promoted	promote	VBD
cord-321401-w4ne60fn	230	37	antibacterial	antibacterial	JJ
cord-321401-w4ne60fn	230	38	effects	effect	NNS
cord-321401-w4ne60fn	230	39	on	on	IN
cord-321401-w4ne60fn	230	40	the	the	DT
cord-321401-w4ne60fn	230	41	mucosa	mucosa	NN
cord-321401-w4ne60fn	230	42	of	of	IN
cord-321401-w4ne60fn	230	43	the	the	DT
cord-321401-w4ne60fn	230	44	skin	skin	NN
cord-321401-w4ne60fn	230	45	(	(	-LRB-
cord-321401-w4ne60fn	230	46	157	157	CD
cord-321401-w4ne60fn	230	47	)	)	-RRB-
cord-321401-w4ne60fn	230	48	.	.	.
cord-321401-w4ne60fn	231	1	There	there	EX
cord-321401-w4ne60fn	231	2	are	be	VBP
cord-321401-w4ne60fn	231	3	also	also	RB
cord-321401-w4ne60fn	231	4	multiple	multiple	JJ
cord-321401-w4ne60fn	231	5	other	other	JJ
cord-321401-w4ne60fn	231	6	murine	murine	JJ
cord-321401-w4ne60fn	231	7	studies	study	NNS
cord-321401-w4ne60fn	231	8	that	that	WDT
cord-321401-w4ne60fn	231	9	demonstrate	demonstrate	VBP
cord-321401-w4ne60fn	231	10	protective	protective	JJ
cord-321401-w4ne60fn	231	11	effects	effect	NNS
cord-321401-w4ne60fn	231	12	of	of	IN
cord-321401-w4ne60fn	231	13	vitamin	vitamin	NN
cord-321401-w4ne60fn	231	14	D	d	NN
cord-321401-w4ne60fn	231	15	on	on	IN
cord-321401-w4ne60fn	231	16	bacterial	bacterial	JJ
cord-321401-w4ne60fn	231	17	infections	infection	NNS
cord-321401-w4ne60fn	231	18	in	in	IN
cord-321401-w4ne60fn	231	19	the	the	DT
cord-321401-w4ne60fn	231	20	gut	gut	NN
cord-321401-w4ne60fn	231	21	,	,	,
cord-321401-w4ne60fn	231	22	indicating	indicate	VBG
cord-321401-w4ne60fn	231	23	that	that	IN
cord-321401-w4ne60fn	231	24	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	231	25	)	)	-RRB-
cord-321401-w4ne60fn	231	26	2	2	CD
cord-321401-w4ne60fn	231	27	Dmediated	dmediated	JJ
cord-321401-w4ne60fn	231	28	antibacterial	antibacterial	JJ
cord-321401-w4ne60fn	231	29	effects	effect	NNS
cord-321401-w4ne60fn	231	30	are	be	VBP
cord-321401-w4ne60fn	231	31	additional	additional	JJ
cord-321401-w4ne60fn	231	32	modulated	modulate	VBN
cord-321401-w4ne60fn	231	33	by	by	IN
cord-321401-w4ne60fn	231	34	other	other	JJ
cord-321401-w4ne60fn	231	35	mechanisms	mechanism	NNS
cord-321401-w4ne60fn	231	36	such	such	JJ
cord-321401-w4ne60fn	231	37	as	as	IN
cord-321401-w4ne60fn	231	38	via	via	IN
cord-321401-w4ne60fn	231	39	enhancement	enhancement	NN
cord-321401-w4ne60fn	231	40	of	of	IN
cord-321401-w4ne60fn	231	41	epithelial	epithelial	JJ
cord-321401-w4ne60fn	231	42	barrier	barrier	NN
cord-321401-w4ne60fn	231	43	integrity	integrity	NN
cord-321401-w4ne60fn	231	44	(	(	-LRB-
cord-321401-w4ne60fn	231	45	67	67	CD
cord-321401-w4ne60fn	231	46	,	,	,
cord-321401-w4ne60fn	231	47	158	158	CD
cord-321401-w4ne60fn	231	48	)	)	-RRB-
cord-321401-w4ne60fn	231	49	.	.	.
cord-321401-w4ne60fn	232	1	In	in	IN
cord-321401-w4ne60fn	232	2	conclusion	conclusion	NN
cord-321401-w4ne60fn	232	3	,	,	,
cord-321401-w4ne60fn	232	4	these	these	DT
cord-321401-w4ne60fn	232	5	observations	observation	NNS
cord-321401-w4ne60fn	232	6	show	show	VBP
cord-321401-w4ne60fn	232	7	that	that	IN
cord-321401-w4ne60fn	232	8	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	232	9	)	)	-RRB-
cord-321401-w4ne60fn	232	10	2	2	CD
cord-321401-w4ne60fn	232	11	D	d	NN
cord-321401-w4ne60fn	232	12	promotes	promote	VBZ
cord-321401-w4ne60fn	232	13	protection	protection	NN
cord-321401-w4ne60fn	232	14	against	against	IN
cord-321401-w4ne60fn	232	15	pollutants	pollutant	NNS
cord-321401-w4ne60fn	232	16	and	and	CC
cord-321401-w4ne60fn	232	17	enhances	enhance	VBZ
cord-321401-w4ne60fn	232	18	clearance	clearance	NN
cord-321401-w4ne60fn	232	19	of	of	IN
cord-321401-w4ne60fn	232	20	viral	viral	JJ
cord-321401-w4ne60fn	232	21	-	-	HYPH
cord-321401-w4ne60fn	232	22	and	and	CC
cord-321401-w4ne60fn	232	23	bacterial	bacterial	JJ
cord-321401-w4ne60fn	232	24	infections	infection	NNS
cord-321401-w4ne60fn	232	25	(	(	-LRB-
cord-321401-w4ne60fn	232	26	both	both	DT
cord-321401-w4ne60fn	232	27	Gram	gram	NN
cord-321401-w4ne60fn	232	28	-	-	HYPH
cord-321401-w4ne60fn	232	29	positive	positive	JJ
cord-321401-w4ne60fn	232	30	and	and	CC
cord-321401-w4ne60fn	232	31	negative	negative	JJ
cord-321401-w4ne60fn	232	32	bacteria	bacteria	NNS
cord-321401-w4ne60fn	232	33	)	)	-RRB-
cord-321401-w4ne60fn	232	34	in	in	IN
cord-321401-w4ne60fn	232	35	combination	combination	NN
cord-321401-w4ne60fn	232	36	with	with	IN
cord-321401-w4ne60fn	232	37	a	a	DT
cord-321401-w4ne60fn	232	38	dampening	dampening	NN
cord-321401-w4ne60fn	232	39	effect	effect	NN
cord-321401-w4ne60fn	232	40	on	on	IN
cord-321401-w4ne60fn	232	41	exaggerated	exaggerated	JJ
cord-321401-w4ne60fn	232	42	immune	immune	JJ
cord-321401-w4ne60fn	232	43	responses	response	NNS
cord-321401-w4ne60fn	232	44	and	and	CC
cord-321401-w4ne60fn	232	45	these	these	DT
cord-321401-w4ne60fn	232	46	features	feature	NNS
cord-321401-w4ne60fn	232	47	might	may	MD
cord-321401-w4ne60fn	232	48	explain	explain	VB
cord-321401-w4ne60fn	232	49	why	why	WRB
cord-321401-w4ne60fn	232	50	vitamin	vitamin	NN
cord-321401-w4ne60fn	232	51	D	d	NN
cord-321401-w4ne60fn	232	52	(	(	-LRB-
cord-321401-w4ne60fn	232	53	deficiency	deficiency	NN
cord-321401-w4ne60fn	232	54	)	)	-RRB-
cord-321401-w4ne60fn	232	55	is	be	VBZ
cord-321401-w4ne60fn	232	56	linked	link	VBN
cord-321401-w4ne60fn	232	57	to	to	IN
cord-321401-w4ne60fn	232	58	COPD	COPD	NNP
cord-321401-w4ne60fn	232	59	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	232	60	.	.	.
cord-321401-w4ne60fn	233	1	There	there	EX
cord-321401-w4ne60fn	233	2	are	be	VBP
cord-321401-w4ne60fn	233	3	strong	strong	JJ
cord-321401-w4ne60fn	233	4	indications	indication	NNS
cord-321401-w4ne60fn	233	5	that	that	IN
cord-321401-w4ne60fn	233	6	modulation	modulation	NN
cord-321401-w4ne60fn	233	7	of	of	IN
cord-321401-w4ne60fn	233	8	immune	immune	JJ
cord-321401-w4ne60fn	233	9	responses	response	NNS
cord-321401-w4ne60fn	233	10	and	and	CC
cord-321401-w4ne60fn	233	11	antibacterial	antibacterial	JJ
cord-321401-w4ne60fn	233	12	activities	activity	NNS
cord-321401-w4ne60fn	233	13	by	by	IN
cord-321401-w4ne60fn	233	14	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	233	15	)	)	-RRB-
cord-321401-w4ne60fn	233	16	2	2	CD
cord-321401-w4ne60fn	233	17	D	d	NN
cord-321401-w4ne60fn	233	18	and/or	and/or	CC
cord-321401-w4ne60fn	233	19	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	233	20	)	)	-RRB-
cord-321401-w4ne60fn	233	21	2	2	CD
cord-321401-w4ne60fn	233	22	D	d	NN
cord-321401-w4ne60fn	233	23	-	-	HYPH
cord-321401-w4ne60fn	233	24	regulated	regulate	VBN
cord-321401-w4ne60fn	233	25	AMPs	amp	NNS
cord-321401-w4ne60fn	233	26	as	as	RB
cord-321401-w4ne60fn	233	27	well	well	RB
cord-321401-w4ne60fn	233	28	as	as	IN
cord-321401-w4ne60fn	233	29	autophagy	autophagy	NN
cord-321401-w4ne60fn	233	30	have	have	VBP
cord-321401-w4ne60fn	233	31	implications	implication	NNS
cord-321401-w4ne60fn	233	32	for	for	IN
cord-321401-w4ne60fn	233	33	the	the	DT
cord-321401-w4ne60fn	233	34	composition	composition	NN
cord-321401-w4ne60fn	233	35	of	of	IN
cord-321401-w4ne60fn	233	36	the	the	DT
cord-321401-w4ne60fn	233	37	microbiota	microbiota	NN
cord-321401-w4ne60fn	233	38	at	at	IN
cord-321401-w4ne60fn	233	39	the	the	DT
cord-321401-w4ne60fn	233	40	epithelial	epithelial	JJ
cord-321401-w4ne60fn	233	41	mucosa	mucosa	NN
cord-321401-w4ne60fn	233	42	of	of	IN
cord-321401-w4ne60fn	233	43	the	the	DT
cord-321401-w4ne60fn	233	44	airways	airway	NNS
cord-321401-w4ne60fn	233	45	and	and	CC
cord-321401-w4ne60fn	233	46	the	the	DT
cord-321401-w4ne60fn	233	47	gut	gut	NN
cord-321401-w4ne60fn	233	48	(	(	-LRB-
cord-321401-w4ne60fn	233	49	159	159	CD
cord-321401-w4ne60fn	233	50	)	)	-RRB-
cord-321401-w4ne60fn	233	51	.	.	.
cord-321401-w4ne60fn	234	1	Evidence	evidence	NN
cord-321401-w4ne60fn	234	2	for	for	IN
cord-321401-w4ne60fn	234	3	a	a	DT
cord-321401-w4ne60fn	234	4	role	role	NN
cord-321401-w4ne60fn	234	5	of	of	IN
cord-321401-w4ne60fn	234	6	AMPs	amp	NNS
cord-321401-w4ne60fn	234	7	in	in	IN
cord-321401-w4ne60fn	234	8	regulating	regulate	VBG
cord-321401-w4ne60fn	234	9	the	the	DT
cord-321401-w4ne60fn	234	10	composition	composition	NN
cord-321401-w4ne60fn	234	11	of	of	IN
cord-321401-w4ne60fn	234	12	the	the	DT
cord-321401-w4ne60fn	234	13	microbiota	microbiota	NN
cord-321401-w4ne60fn	234	14	in	in	IN
cord-321401-w4ne60fn	234	15	the	the	DT
cord-321401-w4ne60fn	234	16	gut	gut	NN
cord-321401-w4ne60fn	234	17	came	come	VBD
cord-321401-w4ne60fn	234	18	from	from	IN
cord-321401-w4ne60fn	234	19	a	a	DT
cord-321401-w4ne60fn	234	20	variety	variety	NN
cord-321401-w4ne60fn	234	21	of	of	IN
cord-321401-w4ne60fn	234	22	studies	study	NNS
cord-321401-w4ne60fn	234	23	,	,	,
cord-321401-w4ne60fn	234	24	including	include	VBG
cord-321401-w4ne60fn	234	25	those	those	DT
cord-321401-w4ne60fn	234	26	showing	show	VBG
cord-321401-w4ne60fn	234	27	that	that	IN
cord-321401-w4ne60fn	234	28	Paneth	Paneth	NNP
cord-321401-w4ne60fn	234	29	cell	cell	NN
cord-321401-w4ne60fn	234	30	-	-	HYPH
cord-321401-w4ne60fn	234	31	derived	derive	VBN
cord-321401-w4ne60fn	234	32	defensins	defensin	NNS
cord-321401-w4ne60fn	234	33	may	may	MD
cord-321401-w4ne60fn	234	34	modulate	modulate	VB
cord-321401-w4ne60fn	234	35	the	the	DT
cord-321401-w4ne60fn	234	36	composition	composition	NN
cord-321401-w4ne60fn	234	37	of	of	IN
cord-321401-w4ne60fn	234	38	the	the	DT
cord-321401-w4ne60fn	234	39	microbiome	microbiome	NN
cord-321401-w4ne60fn	234	40	(	(	-LRB-
cord-321401-w4ne60fn	234	41	160	160	CD
cord-321401-w4ne60fn	234	42	)	)	-RRB-
cord-321401-w4ne60fn	234	43	.	.	.
cord-321401-w4ne60fn	235	1	This	this	DT
cord-321401-w4ne60fn	235	2	notion	notion	NN
cord-321401-w4ne60fn	235	3	is	be	VBZ
cord-321401-w4ne60fn	235	4	further	further	RB
cord-321401-w4ne60fn	235	5	supported	support	VBN
cord-321401-w4ne60fn	235	6	by	by	IN
cord-321401-w4ne60fn	235	7	observations	observation	NNS
cord-321401-w4ne60fn	235	8	showing	show	VBG
cord-321401-w4ne60fn	235	9	that	that	IN
cord-321401-w4ne60fn	235	10	many	many	JJ
cord-321401-w4ne60fn	235	11	commensal	commensal	JJ
cord-321401-w4ne60fn	235	12	gut	gut	NN
cord-321401-w4ne60fn	235	13	bacteria	bacteria	NNS
cord-321401-w4ne60fn	235	14	are	be	VBP
cord-321401-w4ne60fn	235	15	protected	protect	VBN
cord-321401-w4ne60fn	235	16	from	from	IN
cord-321401-w4ne60fn	235	17	killing	kill	VBG
cord-321401-w4ne60fn	235	18	by	by	IN
cord-321401-w4ne60fn	235	19	AMPs	amp	NNS
cord-321401-w4ne60fn	235	20	such	such	JJ
cord-321401-w4ne60fn	235	21	as	as	IN
cord-321401-w4ne60fn	235	22	the	the	DT
cord-321401-w4ne60fn	235	23	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	235	24	)	)	-RRB-
cord-321401-w4ne60fn	235	25	2	2	CD
cord-321401-w4ne60fn	235	26	D	d	NN
cord-321401-w4ne60fn	235	27	-	-	HYPH
cord-321401-w4ne60fn	235	28	inducible	inducible	JJ
cord-321401-w4ne60fn	235	29	hCAP18	hCAP18	NNP
cord-321401-w4ne60fn	235	30	/	/	SYM
cord-321401-w4ne60fn	235	31	LL-37	LL-37	NNP
cord-321401-w4ne60fn	235	32	and	and	CC
cord-321401-w4ne60fn	235	33	hBD-2	hBD-2	NNP
cord-321401-w4ne60fn	235	34	,	,	,
cord-321401-w4ne60fn	235	35	whereas	whereas	IN
cord-321401-w4ne60fn	235	36	pathogens	pathogen	NNS
cord-321401-w4ne60fn	235	37	are	be	VBP
cord-321401-w4ne60fn	235	38	in	in	IN
cord-321401-w4ne60fn	235	39	general	general	JJ
cord-321401-w4ne60fn	235	40	more	more	RBR
cord-321401-w4ne60fn	235	41	sensitive	sensitive	JJ
cord-321401-w4ne60fn	235	42	(	(	-LRB-
cord-321401-w4ne60fn	235	43	161	161	CD
cord-321401-w4ne60fn	235	44	)	)	-RRB-
cord-321401-w4ne60fn	235	45	.	.	.
cord-321401-w4ne60fn	236	1	Alterations	alteration	NNS
cord-321401-w4ne60fn	236	2	in	in	IN
cord-321401-w4ne60fn	236	3	the	the	DT
cord-321401-w4ne60fn	236	4	gut	gut	NN
cord-321401-w4ne60fn	236	5	microbiota	microbiota	NN
cord-321401-w4ne60fn	236	6	have	have	VBP
cord-321401-w4ne60fn	236	7	been	be	VBN
cord-321401-w4ne60fn	236	8	linked	link	VBN
cord-321401-w4ne60fn	236	9	to	to	IN
cord-321401-w4ne60fn	236	10	many	many	JJ
cord-321401-w4ne60fn	236	11	diseases	disease	NNS
cord-321401-w4ne60fn	236	12	of	of	IN
cord-321401-w4ne60fn	236	13	the	the	DT
cord-321401-w4ne60fn	236	14	gut	gut	NN
cord-321401-w4ne60fn	236	15	such	such	JJ
cord-321401-w4ne60fn	236	16	as	as	IN
cord-321401-w4ne60fn	236	17	IBD	IBD	NNP
cord-321401-w4ne60fn	236	18	but	but	CC
cord-321401-w4ne60fn	236	19	also	also	RB
cord-321401-w4ne60fn	236	20	with	with	IN
cord-321401-w4ne60fn	236	21	diseases	disease	NNS
cord-321401-w4ne60fn	236	22	affecting	affect	VBG
cord-321401-w4ne60fn	236	23	the	the	DT
cord-321401-w4ne60fn	236	24	lungs	lung	NNS
cord-321401-w4ne60fn	236	25	such	such	JJ
cord-321401-w4ne60fn	236	26	as	as	IN
cord-321401-w4ne60fn	236	27	COPD	COPD	NNP
cord-321401-w4ne60fn	236	28	and	and	CC
cord-321401-w4ne60fn	236	29	asthma	asthma	NN
cord-321401-w4ne60fn	236	30	,	,	,
cord-321401-w4ne60fn	236	31	implicating	implicate	VBG
cord-321401-w4ne60fn	236	32	an	an	DT
cord-321401-w4ne60fn	236	33	important	important	JJ
cord-321401-w4ne60fn	236	34	role	role	NN
cord-321401-w4ne60fn	236	35	for	for	IN
cord-321401-w4ne60fn	236	36	the	the	DT
cord-321401-w4ne60fn	236	37	so	so	RB
cord-321401-w4ne60fn	236	38	-	-	HYPH
cord-321401-w4ne60fn	236	39	called	call	VBN
cord-321401-w4ne60fn	236	40	gut	gut	NN
cord-321401-w4ne60fn	236	41	-	-	HYPH
cord-321401-w4ne60fn	236	42	lung	lung	NN
cord-321401-w4ne60fn	236	43	axis	axis	NN
cord-321401-w4ne60fn	236	44	(	(	-LRB-
cord-321401-w4ne60fn	236	45	162	162	CD
cord-321401-w4ne60fn	236	46	,	,	,
cord-321401-w4ne60fn	236	47	163	163	CD
cord-321401-w4ne60fn	236	48	)	)	-RRB-
cord-321401-w4ne60fn	236	49	.	.	.
cord-321401-w4ne60fn	237	1	The	the	DT
cord-321401-w4ne60fn	237	2	mechanisms	mechanism	NNS
cord-321401-w4ne60fn	237	3	that	that	WDT
cord-321401-w4ne60fn	237	4	explain	explain	VBP
cord-321401-w4ne60fn	237	5	how	how	WRB
cord-321401-w4ne60fn	237	6	gut	gut	NN
cord-321401-w4ne60fn	237	7	microbiota	microbiota	NN
cord-321401-w4ne60fn	237	8	affect	affect	VBP
cord-321401-w4ne60fn	237	9	lung	lung	NN
cord-321401-w4ne60fn	237	10	health	health	NN
cord-321401-w4ne60fn	237	11	and	and	CC
cord-321401-w4ne60fn	237	12	disease	disease	NN
cord-321401-w4ne60fn	237	13	are	be	VBP
cord-321401-w4ne60fn	237	14	complex	complex	JJ
cord-321401-w4ne60fn	237	15	and	and	CC
cord-321401-w4ne60fn	237	16	include	include	VBP
cord-321401-w4ne60fn	237	17	the	the	DT
cord-321401-w4ne60fn	237	18	production	production	NN
cord-321401-w4ne60fn	237	19	of	of	IN
cord-321401-w4ne60fn	237	20	short	short	JJ
cord-321401-w4ne60fn	237	21	chain	chain	NN
cord-321401-w4ne60fn	237	22	fatty	fatty	JJ
cord-321401-w4ne60fn	237	23	acids	acid	NNS
cord-321401-w4ne60fn	237	24	(	(	-LRB-
cord-321401-w4ne60fn	237	25	SCFAs	SCFAs	NNP
cord-321401-w4ne60fn	237	26	)	)	-RRB-
cord-321401-w4ne60fn	237	27	.	.	.
cord-321401-w4ne60fn	238	1	SCFA	SCFA	NNP
cord-321401-w4ne60fn	238	2	have	have	VBP
cord-321401-w4ne60fn	238	3	a	a	DT
cord-321401-w4ne60fn	238	4	wide	wide	JJ
cord-321401-w4ne60fn	238	5	range	range	NN
cord-321401-w4ne60fn	238	6	of	of	IN
cord-321401-w4ne60fn	238	7	effects	effect	NNS
cord-321401-w4ne60fn	238	8	on	on	IN
cord-321401-w4ne60fn	238	9	both	both	DT
cord-321401-w4ne60fn	238	10	immune	immune	JJ
cord-321401-w4ne60fn	238	11	and	and	CC
cord-321401-w4ne60fn	238	12	structural	structural	JJ
cord-321401-w4ne60fn	238	13	cells	cell	NNS
cord-321401-w4ne60fn	238	14	,	,	,
cord-321401-w4ne60fn	238	15	and	and	CC
cord-321401-w4ne60fn	238	16	the	the	DT
cord-321401-w4ne60fn	238	17	effect	effect	NN
cord-321401-w4ne60fn	238	18	of	of	IN
cord-321401-w4ne60fn	238	19	SCFA	SCFA	NNP
cord-321401-w4ne60fn	238	20	produced	produce	VBN
cord-321401-w4ne60fn	238	21	in	in	IN
cord-321401-w4ne60fn	238	22	the	the	DT
cord-321401-w4ne60fn	238	23	intestine	intestine	NN
cord-321401-w4ne60fn	238	24	on	on	IN
cord-321401-w4ne60fn	238	25	lung	lung	NN
cord-321401-w4ne60fn	238	26	immunity	immunity	NN
cord-321401-w4ne60fn	238	27	may	may	MD
cord-321401-w4ne60fn	238	28	in	in	IN
cord-321401-w4ne60fn	238	29	part	part	NN
cord-321401-w4ne60fn	238	30	be	be	VB
cord-321401-w4ne60fn	238	31	explained	explain	VBN
cord-321401-w4ne60fn	238	32	by	by	IN
cord-321401-w4ne60fn	238	33	modulation	modulation	NN
cord-321401-w4ne60fn	238	34	of	of	IN
cord-321401-w4ne60fn	238	35	myeloid	myeloid	NN
cord-321401-w4ne60fn	238	36	cells	cell	NNS
cord-321401-w4ne60fn	238	37	in	in	IN
cord-321401-w4ne60fn	238	38	the	the	DT
cord-321401-w4ne60fn	238	39	bone	bone	NN
cord-321401-w4ne60fn	238	40	marrow	marrow	NN
cord-321401-w4ne60fn	238	41	,	,	,
cord-321401-w4ne60fn	238	42	which	which	WDT
cord-321401-w4ne60fn	238	43	subsequently	subsequently	RB
cord-321401-w4ne60fn	238	44	migrate	migrate	VBP
cord-321401-w4ne60fn	238	45	to	to	IN
cord-321401-w4ne60fn	238	46	the	the	DT
cord-321401-w4ne60fn	238	47	airways	airway	NNS
cord-321401-w4ne60fn	238	48	and	and	CC
cord-321401-w4ne60fn	238	49	modulate	modulate	VB
cord-321401-w4ne60fn	238	50	local	local	JJ
cord-321401-w4ne60fn	238	51	immune	immune	JJ
cord-321401-w4ne60fn	238	52	responses	response	NNS
cord-321401-w4ne60fn	238	53	(	(	-LRB-
cord-321401-w4ne60fn	238	54	163	163	CD
cord-321401-w4ne60fn	238	55	)	)	-RRB-
cord-321401-w4ne60fn	238	56	.	.	.
cord-321401-w4ne60fn	239	1	Microbiota	Microbiota	NNP
cord-321401-w4ne60fn	239	2	that	that	WDT
cord-321401-w4ne60fn	239	3	are	be	VBP
cord-321401-w4ne60fn	239	4	diverse	diverse	JJ
cord-321401-w4ne60fn	239	5	,	,	,
cord-321401-w4ne60fn	239	6	rich	rich	JJ
cord-321401-w4ne60fn	239	7	and	and	CC
cord-321401-w4ne60fn	239	8	contain	contain	VBP
cord-321401-w4ne60fn	239	9	a	a	DT
cord-321401-w4ne60fn	239	10	higher	high	JJR
cord-321401-w4ne60fn	239	11	abundance	abundance	NN
cord-321401-w4ne60fn	239	12	of	of	IN
cord-321401-w4ne60fn	239	13	SCFAproducing	scfaproduce	VBG
cord-321401-w4ne60fn	239	14	species	specie	NNS
cord-321401-w4ne60fn	239	15	within	within	IN
cord-321401-w4ne60fn	239	16	these	these	DT
cord-321401-w4ne60fn	239	17	populations	population	NNS
cord-321401-w4ne60fn	239	18	are	be	VBP
cord-321401-w4ne60fn	239	19	considered	consider	VBN
cord-321401-w4ne60fn	239	20	to	to	TO
cord-321401-w4ne60fn	239	21	be	be	VB
cord-321401-w4ne60fn	239	22	associated	associate	VBN
cord-321401-w4ne60fn	239	23	with	with	IN
cord-321401-w4ne60fn	239	24	health	health	NN
cord-321401-w4ne60fn	239	25	(	(	-LRB-
cord-321401-w4ne60fn	239	26	164	164	CD
cord-321401-w4ne60fn	239	27	)	)	-RRB-
cord-321401-w4ne60fn	239	28	.	.	.
cord-321401-w4ne60fn	240	1	In	in	IN
cord-321401-w4ne60fn	240	2	the	the	DT
cord-321401-w4ne60fn	240	3	gut	gut	NN
cord-321401-w4ne60fn	240	4	there	there	EX
cord-321401-w4ne60fn	240	5	is	be	VBZ
cord-321401-w4ne60fn	240	6	strong	strong	JJ
cord-321401-w4ne60fn	240	7	evidence	evidence	NN
cord-321401-w4ne60fn	240	8	that	that	IN
cord-321401-w4ne60fn	240	9	both	both	DT
cord-321401-w4ne60fn	240	10	vitamin	vitamin	NN
cord-321401-w4ne60fn	240	11	D	d	NN
cord-321401-w4ne60fn	240	12	deficiency	deficiency	NN
cord-321401-w4ne60fn	240	13	and/or	and/or	CC
cord-321401-w4ne60fn	240	14	supplementation	supplementation	NN
cord-321401-w4ne60fn	240	15	affect	affect	VBP
cord-321401-w4ne60fn	240	16	composition	composition	NN
cord-321401-w4ne60fn	240	17	of	of	IN
cord-321401-w4ne60fn	240	18	the	the	DT
cord-321401-w4ne60fn	240	19	adult	adult	NN
cord-321401-w4ne60fn	240	20	and	and	CC
cord-321401-w4ne60fn	240	21	infant	infant	NN
cord-321401-w4ne60fn	240	22	microbiota	microbiota	NN
cord-321401-w4ne60fn	240	23	(	(	-LRB-
cord-321401-w4ne60fn	240	24	164	164	CD
cord-321401-w4ne60fn	240	25	,	,	,
cord-321401-w4ne60fn	240	26	165	165	CD
cord-321401-w4ne60fn	240	27	)	)	-RRB-
cord-321401-w4ne60fn	240	28	,	,	,
cord-321401-w4ne60fn	240	29	specifically	specifically	RB
cord-321401-w4ne60fn	240	30	in	in	IN
cord-321401-w4ne60fn	240	31	relation	relation	NN
cord-321401-w4ne60fn	240	32	to	to	IN
cord-321401-w4ne60fn	240	33	disease	disease	NN
cord-321401-w4ne60fn	240	34	(	(	-LRB-
cord-321401-w4ne60fn	240	35	166	166	CD
cord-321401-w4ne60fn	240	36	)	)	-RRB-
cord-321401-w4ne60fn	240	37	.	.	.
cord-321401-w4ne60fn	241	1	However	however	RB
cord-321401-w4ne60fn	241	2	,	,	,
cord-321401-w4ne60fn	241	3	due	due	IN
cord-321401-w4ne60fn	241	4	to	to	IN
cord-321401-w4ne60fn	241	5	the	the	DT
cord-321401-w4ne60fn	241	6	limited	limited	JJ
cord-321401-w4ne60fn	241	7	number	number	NN
cord-321401-w4ne60fn	241	8	of	of	IN
cord-321401-w4ne60fn	241	9	RCTs	rct	NNS
cord-321401-w4ne60fn	241	10	and	and	CC
cord-321401-w4ne60fn	241	11	small	small	JJ
cord-321401-w4ne60fn	241	12	sample	sample	NN
cord-321401-w4ne60fn	241	13	sizes	size	NNS
cord-321401-w4ne60fn	241	14	,	,	,
cord-321401-w4ne60fn	241	15	the	the	DT
cord-321401-w4ne60fn	241	16	precise	precise	JJ
cord-321401-w4ne60fn	241	17	effects	effect	NNS
cord-321401-w4ne60fn	241	18	on	on	IN
cord-321401-w4ne60fn	241	19	the	the	DT
cord-321401-w4ne60fn	241	20	microbiota	microbiota	NN
cord-321401-w4ne60fn	241	21	and	and	CC
cord-321401-w4ne60fn	241	22	the	the	DT
cord-321401-w4ne60fn	241	23	mechanisms	mechanism	NNS
cord-321401-w4ne60fn	241	24	involved	involve	VBN
cord-321401-w4ne60fn	241	25	in	in	IN
cord-321401-w4ne60fn	241	26	this	this	DT
cord-321401-w4ne60fn	241	27	are	be	VBP
cord-321401-w4ne60fn	241	28	still	still	RB
cord-321401-w4ne60fn	241	29	unclear	unclear	JJ
cord-321401-w4ne60fn	241	30	(	(	-LRB-
cord-321401-w4ne60fn	241	31	164	164	CD
cord-321401-w4ne60fn	241	32	)	)	-RRB-
cord-321401-w4ne60fn	241	33	.	.	.
cord-321401-w4ne60fn	242	1	Alterations	alteration	NNS
cord-321401-w4ne60fn	242	2	in	in	IN
cord-321401-w4ne60fn	242	3	the	the	DT
cord-321401-w4ne60fn	242	4	lung	lung	NN
cord-321401-w4ne60fn	242	5	microbiota	microbiota	NN
cord-321401-w4ne60fn	242	6	are	be	VBP
cord-321401-w4ne60fn	242	7	also	also	RB
cord-321401-w4ne60fn	242	8	observed	observe	VBN
cord-321401-w4ne60fn	242	9	in	in	IN
cord-321401-w4ne60fn	242	10	COPD	COPD	NNP
cord-321401-w4ne60fn	242	11	and	and	CC
cord-321401-w4ne60fn	242	12	asthma	asthma	NN
cord-321401-w4ne60fn	242	13	patients	patient	NNS
cord-321401-w4ne60fn	242	14	and	and	CC
cord-321401-w4ne60fn	242	15	are	be	VBP
cord-321401-w4ne60fn	242	16	likely	likely	RB
cord-321401-w4ne60fn	242	17	the	the	DT
cord-321401-w4ne60fn	242	18	result	result	NN
cord-321401-w4ne60fn	242	19	of	of	IN
cord-321401-w4ne60fn	242	20	environmental	environmental	JJ
cord-321401-w4ne60fn	242	21	exposures	exposure	NNS
cord-321401-w4ne60fn	242	22	,	,	,
cord-321401-w4ne60fn	242	23	airway	airway	NN
cord-321401-w4ne60fn	242	24	remodeling	remodeling	NN
cord-321401-w4ne60fn	242	25	,	,	,
cord-321401-w4ne60fn	242	26	infections	infection	NNS
cord-321401-w4ne60fn	242	27	and	and	CC
cord-321401-w4ne60fn	242	28	treatments	treatment	NNS
cord-321401-w4ne60fn	242	29	such	such	JJ
cord-321401-w4ne60fn	242	30	as	as	IN
cord-321401-w4ne60fn	242	31	the	the	DT
cord-321401-w4ne60fn	242	32	use	use	NN
cord-321401-w4ne60fn	242	33	of	of	IN
cord-321401-w4ne60fn	242	34	antibiotics	antibiotic	NNS
cord-321401-w4ne60fn	242	35	.	.	.
cord-321401-w4ne60fn	243	1	This	this	DT
cord-321401-w4ne60fn	243	2	may	may	MD
cord-321401-w4ne60fn	243	3	contribute	contribute	VB
cord-321401-w4ne60fn	243	4	to	to	IN
cord-321401-w4ne60fn	243	5	disease	disease	NN
cord-321401-w4ne60fn	243	6	pathogenesis	pathogenesis	NN
cord-321401-w4ne60fn	243	7	through	through	IN
cord-321401-w4ne60fn	243	8	altered	alter	VBN
cord-321401-w4ne60fn	243	9	epithelial	epithelial	JJ
cord-321401-w4ne60fn	243	10	innate	innate	JJ
cord-321401-w4ne60fn	243	11	and	and	CC
cord-321401-w4ne60fn	243	12	adaptive	adaptive	JJ
cord-321401-w4ne60fn	243	13	immune	immune	JJ
cord-321401-w4ne60fn	243	14	responses	response	NNS
cord-321401-w4ne60fn	243	15	that	that	WDT
cord-321401-w4ne60fn	243	16	damages	damage	VBZ
cord-321401-w4ne60fn	243	17	the	the	DT
cord-321401-w4ne60fn	243	18	airway	airway	JJ
cord-321401-w4ne60fn	243	19	epithelial	epithelial	JJ
cord-321401-w4ne60fn	243	20	barrier	barrier	NN
cord-321401-w4ne60fn	243	21	and	and	CC
cord-321401-w4ne60fn	243	22	provokes	provoke	VBZ
cord-321401-w4ne60fn	243	23	further	further	JJ
cord-321401-w4ne60fn	243	24	changes	change	NNS
cord-321401-w4ne60fn	243	25	in	in	IN
cord-321401-w4ne60fn	243	26	the	the	DT
cord-321401-w4ne60fn	243	27	lung	lung	NN
cord-321401-w4ne60fn	243	28	microbiome	microbiome	NN
cord-321401-w4ne60fn	243	29	that	that	WDT
cord-321401-w4ne60fn	243	30	accumulates	accumulate	VBZ
cord-321401-w4ne60fn	243	31	with	with	IN
cord-321401-w4ne60fn	243	32	increasing	increase	VBG
cord-321401-w4ne60fn	243	33	disease	disease	NN
cord-321401-w4ne60fn	243	34	severity	severity	NN
cord-321401-w4ne60fn	243	35	(	(	-LRB-
cord-321401-w4ne60fn	243	36	167	167	CD
cord-321401-w4ne60fn	243	37	,	,	,
cord-321401-w4ne60fn	243	38	168	168	CD
cord-321401-w4ne60fn	243	39	)	)	-RRB-
cord-321401-w4ne60fn	243	40	.	.	.
cord-321401-w4ne60fn	244	1	To	to	IN
cord-321401-w4ne60fn	244	2	date	date	NN
cord-321401-w4ne60fn	244	3	only	only	RB
cord-321401-w4ne60fn	244	4	2	2	CD
cord-321401-w4ne60fn	244	5	studies	study	NNS
cord-321401-w4ne60fn	244	6	describe	describe	VBP
cord-321401-w4ne60fn	244	7	a	a	DT
cord-321401-w4ne60fn	244	8	possible	possible	JJ
cord-321401-w4ne60fn	244	9	influence	influence	NN
cord-321401-w4ne60fn	244	10	of	of	IN
cord-321401-w4ne60fn	244	11	vitamin	vitamin	NN
cord-321401-w4ne60fn	244	12	D	d	NN
cord-321401-w4ne60fn	244	13	on	on	IN
cord-321401-w4ne60fn	244	14	composition	composition	NN
cord-321401-w4ne60fn	244	15	of	of	IN
cord-321401-w4ne60fn	244	16	the	the	DT
cord-321401-w4ne60fn	244	17	microbiota	microbiota	NN
cord-321401-w4ne60fn	244	18	in	in	IN
cord-321401-w4ne60fn	244	19	the	the	DT
cord-321401-w4ne60fn	244	20	airways	airway	NNS
cord-321401-w4ne60fn	244	21	(	(	-LRB-
cord-321401-w4ne60fn	244	22	169	169	CD
cord-321401-w4ne60fn	244	23	,	,	,
cord-321401-w4ne60fn	244	24	170	170	CD
cord-321401-w4ne60fn	244	25	)	)	-RRB-
cord-321401-w4ne60fn	244	26	.	.	.
cord-321401-w4ne60fn	245	1	Toivonen	Toivonen	NNP
cord-321401-w4ne60fn	245	2	et	et	NNP
cord-321401-w4ne60fn	245	3	al	al	NNP
cord-321401-w4ne60fn	245	4	.	.	.
cord-321401-w4ne60fn	246	1	showed	show	VBD
cord-321401-w4ne60fn	246	2	an	an	DT
cord-321401-w4ne60fn	246	3	association	association	NN
cord-321401-w4ne60fn	246	4	between	between	IN
cord-321401-w4ne60fn	246	5	low	low	JJ
cord-321401-w4ne60fn	246	6	serum	serum	NN
cord-321401-w4ne60fn	246	7	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	246	8	levels	level	NNS
cord-321401-w4ne60fn	246	9	and	and	CC
cord-321401-w4ne60fn	246	10	reduced	reduce	VBN
cord-321401-w4ne60fn	246	11	richness	richness	NN
cord-321401-w4ne60fn	246	12	of	of	IN
cord-321401-w4ne60fn	246	13	the	the	DT
cord-321401-w4ne60fn	246	14	nasopharyngeal	nasopharyngeal	JJ
cord-321401-w4ne60fn	246	15	microbiota	microbiota	NN
cord-321401-w4ne60fn	246	16	and	and	CC
cord-321401-w4ne60fn	246	17	bronchiolitis	bronchiolitis	NN
cord-321401-w4ne60fn	246	18	severity	severity	NN
cord-321401-w4ne60fn	246	19	in	in	IN
cord-321401-w4ne60fn	246	20	patients	patient	NNS
cord-321401-w4ne60fn	246	21	with	with	IN
cord-321401-w4ne60fn	246	22	low	low	JJ
cord-321401-w4ne60fn	246	23	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	246	24	levels	level	NNS
cord-321401-w4ne60fn	246	25	(	(	-LRB-
cord-321401-w4ne60fn	246	26	169	169	CD
cord-321401-w4ne60fn	246	27	)	)	-RRB-
cord-321401-w4ne60fn	246	28	,	,	,
cord-321401-w4ne60fn	246	29	whereas	whereas	IN
cord-321401-w4ne60fn	246	30	in	in	IN
cord-321401-w4ne60fn	246	31	another	another	DT
cord-321401-w4ne60fn	246	32	study	study	NN
cord-321401-w4ne60fn	246	33	vitamin	vitamin	NN
cord-321401-w4ne60fn	246	34	D	D	NNP
cord-321401-w4ne60fn	246	35	supplementation	supplementation	NN
cord-321401-w4ne60fn	246	36	decreased	decrease	VBD
cord-321401-w4ne60fn	246	37	the	the	DT
cord-321401-w4ne60fn	246	38	abundance	abundance	NN
cord-321401-w4ne60fn	246	39	of	of	IN
cord-321401-w4ne60fn	246	40	Staphylococcus	Staphylococcus	NNP
cord-321401-w4ne60fn	246	41	aureus	aureus	NN
cord-321401-w4ne60fn	246	42	,	,	,
cord-321401-w4ne60fn	246	43	Staphylococcus	Staphylococcus	NNP
cord-321401-w4ne60fn	246	44	epidermidis	epidermidi	NNS
cord-321401-w4ne60fn	246	45	and	and	CC
cord-321401-w4ne60fn	246	46	Corynebacterium	Corynebacterium	NNP
cord-321401-w4ne60fn	246	47	species	specie	NNS
cord-321401-w4ne60fn	246	48	in	in	IN
cord-321401-w4ne60fn	246	49	sputum	sputum	NN
cord-321401-w4ne60fn	246	50	samples	sample	NNS
cord-321401-w4ne60fn	246	51	in	in	IN
cord-321401-w4ne60fn	246	52	vitamin	vitamin	NN
cord-321401-w4ne60fn	246	53	D	d	NN
cord-321401-w4ne60fn	246	54	-	-	HYPH
cord-321401-w4ne60fn	246	55	deficient	deficient	JJ
cord-321401-w4ne60fn	246	56	CF	cf	NN
cord-321401-w4ne60fn	246	57	patients	patient	NNS
cord-321401-w4ne60fn	246	58	compared	compare	VBN
cord-321401-w4ne60fn	246	59	to	to	IN
cord-321401-w4ne60fn	246	60	sufficient	sufficient	JJ
cord-321401-w4ne60fn	246	61	CF	cf	NN
cord-321401-w4ne60fn	246	62	patients	patient	NNS
cord-321401-w4ne60fn	246	63	(	(	-LRB-
cord-321401-w4ne60fn	246	64	170	170	CD
cord-321401-w4ne60fn	246	65	)	)	-RRB-
cord-321401-w4ne60fn	246	66	.	.	.
cord-321401-w4ne60fn	247	1	In	in	IN
cord-321401-w4ne60fn	247	2	summary	summary	NN
cord-321401-w4ne60fn	247	3	,	,	,
cord-321401-w4ne60fn	247	4	there	there	EX
cord-321401-w4ne60fn	247	5	is	be	VBZ
cord-321401-w4ne60fn	247	6	evidence	evidence	NN
cord-321401-w4ne60fn	247	7	that	that	IN
cord-321401-w4ne60fn	247	8	alterations	alteration	NNS
cord-321401-w4ne60fn	247	9	in	in	IN
cord-321401-w4ne60fn	247	10	the	the	DT
cord-321401-w4ne60fn	247	11	airway	airway	NN
cord-321401-w4ne60fn	247	12	or	or	CC
cord-321401-w4ne60fn	247	13	gut	gut	NN
cord-321401-w4ne60fn	247	14	microbiota	microbiota	NN
cord-321401-w4ne60fn	247	15	can	can	MD
cord-321401-w4ne60fn	247	16	affect	affect	VB
cord-321401-w4ne60fn	247	17	chronic	chronic	JJ
cord-321401-w4ne60fn	247	18	airway	airway	NN
cord-321401-w4ne60fn	247	19	disease	disease	NN
cord-321401-w4ne60fn	247	20	and	and	CC
cord-321401-w4ne60fn	247	21	that	that	IN
cord-321401-w4ne60fn	247	22	these	these	DT
cord-321401-w4ne60fn	247	23	changes	change	NNS
cord-321401-w4ne60fn	247	24	could	could	MD
cord-321401-w4ne60fn	247	25	be	be	VB
cord-321401-w4ne60fn	247	26	related	relate	VBN
cord-321401-w4ne60fn	247	27	to	to	IN
cord-321401-w4ne60fn	247	28	both	both	DT
cord-321401-w4ne60fn	247	29	vitamin	vitamin	NN
cord-321401-w4ne60fn	247	30	D	d	NN
cord-321401-w4ne60fn	247	31	deficiency	deficiency	NN
cord-321401-w4ne60fn	247	32	and/or	and/or	CC
cord-321401-w4ne60fn	247	33	supplementation	supplementation	NN
cord-321401-w4ne60fn	247	34	.	.	.
cord-321401-w4ne60fn	248	1	However	however	RB
cord-321401-w4ne60fn	248	2	,	,	,
cord-321401-w4ne60fn	248	3	due	due	IN
cord-321401-w4ne60fn	248	4	to	to	IN
cord-321401-w4ne60fn	248	5	the	the	DT
cord-321401-w4ne60fn	248	6	limited	limited	JJ
cord-321401-w4ne60fn	248	7	number	number	NN
cord-321401-w4ne60fn	248	8	of	of	IN
cord-321401-w4ne60fn	248	9	RCTs	rct	NNS
cord-321401-w4ne60fn	248	10	and	and	CC
cord-321401-w4ne60fn	248	11	small	small	JJ
cord-321401-w4ne60fn	248	12	sample	sample	NN
cord-321401-w4ne60fn	248	13	sizes	size	NNS
cord-321401-w4ne60fn	248	14	more	more	JJR
cord-321401-w4ne60fn	248	15	RCTs	rct	NNS
cord-321401-w4ne60fn	248	16	are	be	VBP
cord-321401-w4ne60fn	248	17	needed	need	VBN
cord-321401-w4ne60fn	248	18	in	in	IN
cord-321401-w4ne60fn	248	19	larger	large	JJR
cord-321401-w4ne60fn	248	20	patient	patient	NN
cord-321401-w4ne60fn	248	21	populations	population	NNS
cord-321401-w4ne60fn	248	22	.	.	.
cord-321401-w4ne60fn	249	1	The	the	DT
cord-321401-w4ne60fn	249	2	above	above	RB
cord-321401-w4ne60fn	249	3	described	describe	VBN
cord-321401-w4ne60fn	249	4	protective	protective	JJ
cord-321401-w4ne60fn	249	5	and	and	CC
cord-321401-w4ne60fn	249	6	therapeutic	therapeutic	JJ
cord-321401-w4ne60fn	249	7	possibilities	possibility	NNS
cord-321401-w4ne60fn	249	8	of	of	IN
cord-321401-w4ne60fn	249	9	vitamin	vitamin	NN
cord-321401-w4ne60fn	249	10	D	d	NN
cord-321401-w4ne60fn	249	11	,	,	,
cord-321401-w4ne60fn	249	12	together	together	RB
cord-321401-w4ne60fn	249	13	with	with	IN
cord-321401-w4ne60fn	249	14	observations	observation	NNS
cord-321401-w4ne60fn	249	15	that	that	WDT
cord-321401-w4ne60fn	249	16	many	many	JJ
cord-321401-w4ne60fn	249	17	COPD	COPD	NNP
cord-321401-w4ne60fn	249	18	patients	patient	NNS
cord-321401-w4ne60fn	249	19	are	be	VBP
cord-321401-w4ne60fn	249	20	vitamin	vitamin	NN
cord-321401-w4ne60fn	249	21	D	d	NN
cord-321401-w4ne60fn	249	22	deficient	deficient	JJ
cord-321401-w4ne60fn	249	23	,	,	,
cord-321401-w4ne60fn	249	24	suggest	suggest	VBP
cord-321401-w4ne60fn	249	25	that	that	IN
cord-321401-w4ne60fn	249	26	COPD	COPD	NNP
cord-321401-w4ne60fn	249	27	patients	patient	NNS
cord-321401-w4ne60fn	249	28	might	may	MD
cord-321401-w4ne60fn	249	29	benefit	benefit	VB
cord-321401-w4ne60fn	249	30	from	from	IN
cord-321401-w4ne60fn	249	31	vitamin	vitamin	NN
cord-321401-w4ne60fn	249	32	D	d	NN
cord-321401-w4ne60fn	249	33	supplementation	supplementation	NN
cord-321401-w4ne60fn	249	34	.	.	.
cord-321401-w4ne60fn	250	1	As	as	IN
cord-321401-w4ne60fn	250	2	discussed	discuss	VBN
cord-321401-w4ne60fn	250	3	elsewhere	elsewhere	RB
cord-321401-w4ne60fn	250	4	in	in	IN
cord-321401-w4ne60fn	250	5	this	this	DT
cord-321401-w4ne60fn	250	6	review	review	NN
cord-321401-w4ne60fn	250	7	,	,	,
cord-321401-w4ne60fn	250	8	the	the	DT
cord-321401-w4ne60fn	250	9	link	link	NN
cord-321401-w4ne60fn	250	10	between	between	IN
cord-321401-w4ne60fn	250	11	circulating	circulate	VBG
cord-321401-w4ne60fn	250	12	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	250	13	levels	level	NNS
cord-321401-w4ne60fn	250	14	and	and	CC
cord-321401-w4ne60fn	250	15	the	the	DT
cord-321401-w4ne60fn	250	16	number	number	NN
cord-321401-w4ne60fn	250	17	of	of	IN
cord-321401-w4ne60fn	250	18	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	250	19	has	have	VBZ
cord-321401-w4ne60fn	250	20	been	be	VBN
cord-321401-w4ne60fn	250	21	extensively	extensively	RB
cord-321401-w4ne60fn	250	22	studied	study	VBN
cord-321401-w4ne60fn	250	23	(	(	-LRB-
cord-321401-w4ne60fn	250	24	8)	8)	NN
cord-321401-w4ne60fn	250	25	.	.	.
cord-321401-w4ne60fn	251	1	So	so	RB
cord-321401-w4ne60fn	251	2	far	far	RB
cord-321401-w4ne60fn	251	3	however	however	RB
cord-321401-w4ne60fn	251	4	,	,	,
cord-321401-w4ne60fn	251	5	only	only	RB
cord-321401-w4ne60fn	251	6	4	4	CD
cord-321401-w4ne60fn	251	7	RCTs	RCTs	NNPS
cord-321401-w4ne60fn	251	8	have	have	VBP
cord-321401-w4ne60fn	251	9	investigated	investigate	VBN
cord-321401-w4ne60fn	251	10	the	the	DT
cord-321401-w4ne60fn	251	11	effect	effect	NN
cord-321401-w4ne60fn	251	12	of	of	IN
cord-321401-w4ne60fn	251	13	vitamin	vitamin	NN
cord-321401-w4ne60fn	251	14	D	d	NN
cord-321401-w4ne60fn	251	15	supplementation	supplementation	NN
cord-321401-w4ne60fn	251	16	in	in	IN
cord-321401-w4ne60fn	251	17	the	the	DT
cord-321401-w4ne60fn	251	18	context	context	NN
cord-321401-w4ne60fn	251	19	of	of	IN
cord-321401-w4ne60fn	251	20	COPD	COPD	NNP
cord-321401-w4ne60fn	251	21	:	:	:
cord-321401-w4ne60fn	251	22	only	only	RB
cord-321401-w4ne60fn	251	23	2	2	CD
cord-321401-w4ne60fn	251	24	out	out	IN
cord-321401-w4ne60fn	251	25	of	of	IN
cord-321401-w4ne60fn	251	26	4	4	CD
cord-321401-w4ne60fn	251	27	RCTs	RCTs	NNPS
cord-321401-w4ne60fn	251	28	showed	show	VBD
cord-321401-w4ne60fn	251	29	that	that	IN
cord-321401-w4ne60fn	251	30	vitamin	vitamin	NN
cord-321401-w4ne60fn	251	31	D	d	NN
cord-321401-w4ne60fn	251	32	supplementation	supplementation	NN
cord-321401-w4ne60fn	251	33	reduces	reduce	VBZ
cord-321401-w4ne60fn	251	34	the	the	DT
cord-321401-w4ne60fn	251	35	number	number	NN
cord-321401-w4ne60fn	251	36	of	of	IN
cord-321401-w4ne60fn	251	37	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	251	38	(	(	-LRB-
cord-321401-w4ne60fn	251	39	171	171	CD
cord-321401-w4ne60fn	251	40	)	)	-RRB-
cord-321401-w4ne60fn	251	41	(	(	-LRB-
cord-321401-w4ne60fn	251	42	172	172	CD
cord-321401-w4ne60fn	251	43	)	)	-RRB-
cord-321401-w4ne60fn	251	44	(	(	-LRB-
cord-321401-w4ne60fn	251	45	173	173	CD
cord-321401-w4ne60fn	251	46	)	)	-RRB-
cord-321401-w4ne60fn	251	47	(	(	-LRB-
cord-321401-w4ne60fn	251	48	174	174	CD
cord-321401-w4ne60fn	251	49	)	)	-RRB-
cord-321401-w4ne60fn	251	50	.	.	.
cord-321401-w4ne60fn	252	1	However	however	RB
cord-321401-w4ne60fn	252	2	,	,	,
cord-321401-w4ne60fn	252	3	in	in	IN
cord-321401-w4ne60fn	252	4	a	a	DT
cord-321401-w4ne60fn	252	5	post	post	JJ
cord-321401-w4ne60fn	252	6	-	-	JJ
cord-321401-w4ne60fn	252	7	hoc	hoc	JJ
cord-321401-w4ne60fn	252	8	analysis	analysis	NN
cord-321401-w4ne60fn	252	9	,	,	,
cord-321401-w4ne60fn	252	10	selecting	select	VBG
cord-321401-w4ne60fn	252	11	those	those	DT
cord-321401-w4ne60fn	252	12	patients	patient	NNS
cord-321401-w4ne60fn	252	13	that	that	WDT
cord-321401-w4ne60fn	252	14	were	be	VBD
cord-321401-w4ne60fn	252	15	vitamin	vitamin	NN
cord-321401-w4ne60fn	252	16	D	d	NN
cord-321401-w4ne60fn	252	17	deficient	deficient	JJ
cord-321401-w4ne60fn	252	18	,	,	,
cord-321401-w4ne60fn	252	19	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	252	20	were	be	VBD
cord-321401-w4ne60fn	252	21	indeed	indeed	RB
cord-321401-w4ne60fn	252	22	reduced	reduce	VBN
cord-321401-w4ne60fn	252	23	after	after	IN
cord-321401-w4ne60fn	252	24	vitamin	vitamin	NN
cord-321401-w4ne60fn	252	25	D	d	NN
cord-321401-w4ne60fn	252	26	supplementation	supplementation	NN
cord-321401-w4ne60fn	252	27	.	.	.
cord-321401-w4ne60fn	253	1	Jolliffe	Jolliffe	NNP
cord-321401-w4ne60fn	253	2	et	et	NNP
cord-321401-w4ne60fn	253	3	al	al	NNP
cord-321401-w4ne60fn	253	4	.	.	NNP
cord-321401-w4ne60fn	253	5	summarized	summarize	VBD
cord-321401-w4ne60fn	253	6	these	these	DT
cord-321401-w4ne60fn	253	7	4	4	CD
cord-321401-w4ne60fn	253	8	RCTs	RCTs	NNPS
cord-321401-w4ne60fn	253	9	and	and	CC
cord-321401-w4ne60fn	253	10	performed	perform	VBD
cord-321401-w4ne60fn	253	11	a	a	DT
cord-321401-w4ne60fn	253	12	recent	recent	JJ
cord-321401-w4ne60fn	253	13	individual	individual	JJ
cord-321401-w4ne60fn	253	14	participant	participant	NN
cord-321401-w4ne60fn	253	15	data	datum	NNS
cord-321401-w4ne60fn	253	16	meta	meta	NNP
cord-321401-w4ne60fn	253	17	-	-	HYPH
cord-321401-w4ne60fn	253	18	analysis	analysis	NNP
cord-321401-w4ne60fn	253	19	and	and	CC
cord-321401-w4ne60fn	253	20	concluded	conclude	VBD
cord-321401-w4ne60fn	253	21	that	that	IN
cord-321401-w4ne60fn	253	22	vitamin	vitamin	NN
cord-321401-w4ne60fn	253	23	D	D	NNP
cord-321401-w4ne60fn	253	24	supplementation	supplementation	NN
cord-321401-w4ne60fn	253	25	is	be	VBZ
cord-321401-w4ne60fn	253	26	only	only	RB
cord-321401-w4ne60fn	253	27	protective	protective	JJ
cord-321401-w4ne60fn	253	28	against	against	IN
cord-321401-w4ne60fn	253	29	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	253	30	in	in	IN
cord-321401-w4ne60fn	253	31	COPD	COPD	NNP
cord-321401-w4ne60fn	253	32	patients	patient	NNS
cord-321401-w4ne60fn	253	33	with	with	IN
cord-321401-w4ne60fn	253	34	baseline	baseline	JJ
cord-321401-w4ne60fn	253	35	serum	serum	NN
cord-321401-w4ne60fn	253	36	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	253	37	levels	level	NNS
cord-321401-w4ne60fn	253	38	<	<	XX
cord-321401-w4ne60fn	253	39	25	25	CD
cord-321401-w4ne60fn	253	40	nmol	nmol	JJ
cord-321401-w4ne60fn	253	41	/	/	SYM
cord-321401-w4ne60fn	253	42	L	l	NN
cord-321401-w4ne60fn	253	43	(	(	-LRB-
cord-321401-w4ne60fn	253	44	175	175	CD
cord-321401-w4ne60fn	253	45	)	)	-RRB-
cord-321401-w4ne60fn	253	46	.	.	.
cord-321401-w4ne60fn	254	1	These	these	DT
cord-321401-w4ne60fn	254	2	important	important	JJ
cord-321401-w4ne60fn	254	3	findings	finding	NNS
cord-321401-w4ne60fn	254	4	suggest	suggest	VBP
cord-321401-w4ne60fn	254	5	that	that	IN
cord-321401-w4ne60fn	254	6	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	254	7	in	in	IN
cord-321401-w4ne60fn	254	8	this	this	DT
cord-321401-w4ne60fn	254	9	specific	specific	JJ
cord-321401-w4ne60fn	254	10	subset	subset	NN
cord-321401-w4ne60fn	254	11	of	of	IN
cord-321401-w4ne60fn	254	12	COPD	COPD	NNP
cord-321401-w4ne60fn	254	13	patients	patient	NNS
cord-321401-w4ne60fn	254	14	are	be	VBP
cord-321401-w4ne60fn	254	15	connected	connect	VBN
cord-321401-w4ne60fn	254	16	to	to	IN
cord-321401-w4ne60fn	254	17	vitamin	vitamin	NN
cord-321401-w4ne60fn	254	18	D	d	NN
cord-321401-w4ne60fn	254	19	deficiency	deficiency	NN
cord-321401-w4ne60fn	254	20	and	and	CC
cord-321401-w4ne60fn	254	21	this	this	DT
cord-321401-w4ne60fn	254	22	part	part	NN
cord-321401-w4ne60fn	254	23	can	can	MD
cord-321401-w4ne60fn	254	24	be	be	VB
cord-321401-w4ne60fn	254	25	resolved	resolve	VBN
cord-321401-w4ne60fn	254	26	with	with	IN
cord-321401-w4ne60fn	254	27	supplementation	supplementation	NN
cord-321401-w4ne60fn	254	28	.	.	.
cord-321401-w4ne60fn	255	1	In	in	IN
cord-321401-w4ne60fn	255	2	summary	summary	NN
cord-321401-w4ne60fn	255	3	,	,	,
cord-321401-w4ne60fn	255	4	the	the	DT
cord-321401-w4ne60fn	255	5	protective	protective	JJ
cord-321401-w4ne60fn	255	6	effects	effect	NNS
cord-321401-w4ne60fn	255	7	of	of	IN
cord-321401-w4ne60fn	255	8	vitamin	vitamin	NN
cord-321401-w4ne60fn	255	9	D	d	NN
cord-321401-w4ne60fn	255	10	in	in	IN
cord-321401-w4ne60fn	255	11	patients	patient	NNS
cord-321401-w4ne60fn	255	12	suffering	suffer	VBG
cord-321401-w4ne60fn	255	13	from	from	IN
cord-321401-w4ne60fn	255	14	COPD	COPD	NNP
cord-321401-w4ne60fn	255	15	are	be	VBP
cord-321401-w4ne60fn	255	16	most	most	RBS
cord-321401-w4ne60fn	255	17	prominent	prominent	JJ
cord-321401-w4ne60fn	255	18	in	in	IN
cord-321401-w4ne60fn	255	19	those	those	DT
cord-321401-w4ne60fn	255	20	with	with	IN
cord-321401-w4ne60fn	255	21	vitamin	vitamin	NN
cord-321401-w4ne60fn	255	22	D	d	NN
cord-321401-w4ne60fn	255	23	deficiency	deficiency	NN
cord-321401-w4ne60fn	255	24	and	and	CC
cord-321401-w4ne60fn	255	25	this	this	DT
cord-321401-w4ne60fn	255	26	would	would	MD
cord-321401-w4ne60fn	255	27	indicate	indicate	VB
cord-321401-w4ne60fn	255	28	that	that	IN
cord-321401-w4ne60fn	255	29	serum	serum	NN
cord-321401-w4ne60fn	255	30	levels	level	NNS
cord-321401-w4ne60fn	255	31	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	255	32	in	in	IN
cord-321401-w4ne60fn	255	33	these	these	DT
cord-321401-w4ne60fn	255	34	patients	patient	NNS
cord-321401-w4ne60fn	255	35	should	should	MD
cord-321401-w4ne60fn	255	36	always	always	RB
cord-321401-w4ne60fn	255	37	be	be	VB
cord-321401-w4ne60fn	255	38	determined	determine	VBN
cord-321401-w4ne60fn	255	39	before	before	IN
cord-321401-w4ne60fn	255	40	considering	consider	VBG
cord-321401-w4ne60fn	255	41	using	use	VBG
cord-321401-w4ne60fn	255	42	vitamin	vitamin	NN
cord-321401-w4ne60fn	255	43	D	D	NNP
cord-321401-w4ne60fn	255	44	supplementation	supplementation	NN
cord-321401-w4ne60fn	255	45	.	.	.
cord-321401-w4ne60fn	256	1	Since	since	IN
cord-321401-w4ne60fn	256	2	only	only	RB
cord-321401-w4ne60fn	256	3	4	4	CD
cord-321401-w4ne60fn	256	4	RCTs	rct	NNS
cord-321401-w4ne60fn	256	5	with	with	IN
cord-321401-w4ne60fn	256	6	relatively	relatively	RB
cord-321401-w4ne60fn	256	7	small	small	JJ
cord-321401-w4ne60fn	256	8	patient	patient	JJ
cord-321401-w4ne60fn	256	9	populations	population	NNS
cord-321401-w4ne60fn	256	10	have	have	VBP
cord-321401-w4ne60fn	256	11	been	be	VBN
cord-321401-w4ne60fn	256	12	conducted	conduct	VBN
cord-321401-w4ne60fn	256	13	in	in	IN
cord-321401-w4ne60fn	256	14	both	both	DT
cord-321401-w4ne60fn	256	15	vitamin	vitamin	NN
cord-321401-w4ne60fn	256	16	D	d	NN
cord-321401-w4ne60fn	256	17	-	-	HYPH
cord-321401-w4ne60fn	256	18	sufficient	sufficient	JJ
cord-321401-w4ne60fn	256	19	and	and	CC
cord-321401-w4ne60fn	256	20	-deficient	-deficient	.
cord-321401-w4ne60fn	257	1	COPD	COPD	NNP
cord-321401-w4ne60fn	257	2	patients	patient	NNS
cord-321401-w4ne60fn	257	3	,	,	,
cord-321401-w4ne60fn	257	4	more	more	JJR
cord-321401-w4ne60fn	257	5	RCTs	rct	NNS
cord-321401-w4ne60fn	257	6	are	be	VBP
cord-321401-w4ne60fn	257	7	needed	need	VBN
cord-321401-w4ne60fn	257	8	,	,	,
cord-321401-w4ne60fn	257	9	especially	especially	RB
cord-321401-w4ne60fn	257	10	in	in	IN
cord-321401-w4ne60fn	257	11	vitamin	vitamin	NN
cord-321401-w4ne60fn	257	12	D	d	NN
cord-321401-w4ne60fn	257	13	-	-	HYPH
cord-321401-w4ne60fn	257	14	deficient	deficient	JJ
cord-321401-w4ne60fn	257	15	patients	patient	NNS
cord-321401-w4ne60fn	257	16	.	.	.
cord-321401-w4ne60fn	258	1	Currently	currently	RB
cord-321401-w4ne60fn	258	2	,	,	,
cord-321401-w4ne60fn	258	3	a	a	DT
cord-321401-w4ne60fn	258	4	multicenter	multicenter	JJ
cord-321401-w4ne60fn	258	5	RCT	RCT	NNP
cord-321401-w4ne60fn	258	6	is	be	VBZ
cord-321401-w4ne60fn	258	7	being	be	VBG
cord-321401-w4ne60fn	258	8	conducted	conduct	VBN
cord-321401-w4ne60fn	258	9	by	by	IN
cord-321401-w4ne60fn	258	10	Rafiq	Rafiq	NNP
cord-321401-w4ne60fn	258	11	et	et	NNP
cord-321401-w4ne60fn	258	12	al	al	NNP
cord-321401-w4ne60fn	258	13	.	.	.
cord-321401-w4ne60fn	259	1	in	in	IN
cord-321401-w4ne60fn	259	2	a	a	DT
cord-321401-w4ne60fn	259	3	group	group	NN
cord-321401-w4ne60fn	259	4	of	of	IN
cord-321401-w4ne60fn	259	5	vitamin	vitamin	NN
cord-321401-w4ne60fn	259	6	-	-	HYPH
cord-321401-w4ne60fn	259	7	deficient	deficient	JJ
cord-321401-w4ne60fn	259	8	COPD	COPD	NNP
cord-321401-w4ne60fn	259	9	patients	patient	NNS
cord-321401-w4ne60fn	259	10	(	(	-LRB-
cord-321401-w4ne60fn	259	11	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	259	12	<	<	XX
cord-321401-w4ne60fn	259	13	50	50	CD
cord-321401-w4ne60fn	259	14	nmol	nmol	JJ
cord-321401-w4ne60fn	259	15	/	/	SYM
cord-321401-w4ne60fn	259	16	L	L	NNP
cord-321401-w4ne60fn	259	17	)	)	-RRB-
cord-321401-w4ne60fn	259	18	,	,	,
cord-321401-w4ne60fn	259	19	which	which	WDT
cord-321401-w4ne60fn	259	20	may	may	MD
cord-321401-w4ne60fn	259	21	reveal	reveal	VB
cord-321401-w4ne60fn	259	22	whether	whether	IN
cord-321401-w4ne60fn	259	23	vitamin	vitamin	NN
cord-321401-w4ne60fn	259	24	D	d	NN
cord-321401-w4ne60fn	259	25	supplementation	supplementation	NN
cord-321401-w4ne60fn	259	26	is	be	VBZ
cord-321401-w4ne60fn	259	27	indeed	indeed	RB
cord-321401-w4ne60fn	259	28	protective	protective	JJ
cord-321401-w4ne60fn	259	29	against	against	IN
cord-321401-w4ne60fn	259	30	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	259	31	in	in	IN
cord-321401-w4ne60fn	259	32	this	this	DT
cord-321401-w4ne60fn	259	33	group	group	NN
cord-321401-w4ne60fn	259	34	(	(	-LRB-
cord-321401-w4ne60fn	259	35	176	176	CD
cord-321401-w4ne60fn	259	36	)	)	-RRB-
cord-321401-w4ne60fn	259	37	.	.	.
cord-321401-w4ne60fn	260	1	In	in	IN
cord-321401-w4ne60fn	260	2	addition	addition	NN
cord-321401-w4ne60fn	260	3	to	to	IN
cord-321401-w4ne60fn	260	4	the	the	DT
cord-321401-w4ne60fn	260	5	effects	effect	NNS
cord-321401-w4ne60fn	260	6	of	of	IN
cord-321401-w4ne60fn	260	7	vitamin	vitamin	NN
cord-321401-w4ne60fn	260	8	D	d	NN
cord-321401-w4ne60fn	260	9	supplementation	supplementation	NN
cord-321401-w4ne60fn	260	10	in	in	IN
cord-321401-w4ne60fn	260	11	COPD	COPD	NNP
cord-321401-w4ne60fn	260	12	patients	patient	NNS
cord-321401-w4ne60fn	260	13	,	,	,
cord-321401-w4ne60fn	260	14	the	the	DT
cord-321401-w4ne60fn	260	15	effects	effect	NNS
cord-321401-w4ne60fn	260	16	of	of	IN
cord-321401-w4ne60fn	260	17	vitamin	vitamin	NN
cord-321401-w4ne60fn	260	18	D	D	NNP
cord-321401-w4ne60fn	260	19	supplementation	supplementation	NN
cord-321401-w4ne60fn	260	20	has	have	VBZ
cord-321401-w4ne60fn	260	21	also	also	RB
cord-321401-w4ne60fn	260	22	been	be	VBN
cord-321401-w4ne60fn	260	23	extensively	extensively	RB
cord-321401-w4ne60fn	260	24	investigated	investigate	VBN
cord-321401-w4ne60fn	260	25	in	in	IN
cord-321401-w4ne60fn	260	26	other	other	JJ
cord-321401-w4ne60fn	260	27	lung	lung	NN
cord-321401-w4ne60fn	260	28	diseases	disease	NNS
cord-321401-w4ne60fn	260	29	(	(	-LRB-
cord-321401-w4ne60fn	260	30	which	which	WDT
cord-321401-w4ne60fn	260	31	have	have	VBP
cord-321401-w4ne60fn	260	32	associations	association	NNS
cord-321401-w4ne60fn	260	33	with	with	IN
cord-321401-w4ne60fn	260	34	vitamin	vitamin	NN
cord-321401-w4ne60fn	260	35	D	d	NN
cord-321401-w4ne60fn	260	36	deficiency	deficiency	NN
cord-321401-w4ne60fn	260	37	)	)	-RRB-
cord-321401-w4ne60fn	260	38	such	such	JJ
cord-321401-w4ne60fn	260	39	as	as	IN
cord-321401-w4ne60fn	260	40	asthma	asthma	NN
cord-321401-w4ne60fn	260	41	,	,	,
cord-321401-w4ne60fn	260	42	cystic	cystic	JJ
cord-321401-w4ne60fn	260	43	fibrosis	fibrosis	NN
cord-321401-w4ne60fn	260	44	,	,	,
cord-321401-w4ne60fn	260	45	upper	upper	JJ
cord-321401-w4ne60fn	260	46	respiratory	respiratory	JJ
cord-321401-w4ne60fn	260	47	tract	tract	NN
cord-321401-w4ne60fn	260	48	infections	infection	NNS
cord-321401-w4ne60fn	260	49	.	.	.
cord-321401-w4ne60fn	261	1	Most	Most	JJS
cord-321401-w4ne60fn	261	2	RCTs	rct	NNS
cord-321401-w4ne60fn	261	3	that	that	WDT
cord-321401-w4ne60fn	261	4	investigated	investigate	VBD
cord-321401-w4ne60fn	261	5	the	the	DT
cord-321401-w4ne60fn	261	6	effects	effect	NNS
cord-321401-w4ne60fn	261	7	of	of	IN
cord-321401-w4ne60fn	261	8	vitamin	vitamin	NN
cord-321401-w4ne60fn	261	9	D	d	NN
cord-321401-w4ne60fn	261	10	supplementation	supplementation	NN
cord-321401-w4ne60fn	261	11	were	be	VBD
cord-321401-w4ne60fn	261	12	performed	perform	VBN
cord-321401-w4ne60fn	261	13	in	in	IN
cord-321401-w4ne60fn	261	14	acute	acute	JJ
cord-321401-w4ne60fn	261	15	respiratory	respiratory	JJ
cord-321401-w4ne60fn	261	16	tract	tract	NN
cord-321401-w4ne60fn	261	17	infections	infection	NNS
cord-321401-w4ne60fn	261	18	(	(	-LRB-
cord-321401-w4ne60fn	261	19	ARTIs	arti	NNS
cord-321401-w4ne60fn	261	20	)	)	-RRB-
cord-321401-w4ne60fn	261	21	and	and	CC
cord-321401-w4ne60fn	261	22	asthma	asthma	NN
cord-321401-w4ne60fn	261	23	.	.	.
cord-321401-w4ne60fn	262	1	A	a	DT
cord-321401-w4ne60fn	262	2	recent	recent	JJ
cord-321401-w4ne60fn	262	3	meta	meta	JJ
cord-321401-w4ne60fn	262	4	-	-	HYPH
cord-321401-w4ne60fn	262	5	analysis	analysis	NN
cord-321401-w4ne60fn	262	6	that	that	WDT
cord-321401-w4ne60fn	262	7	assessed	assess	VBD
cord-321401-w4ne60fn	262	8	the	the	DT
cord-321401-w4ne60fn	262	9	effects	effect	NNS
cord-321401-w4ne60fn	262	10	of	of	IN
cord-321401-w4ne60fn	262	11	vitamin	vitamin	NN
cord-321401-w4ne60fn	262	12	D	d	NN
cord-321401-w4ne60fn	262	13	supplementation	supplementation	NN
cord-321401-w4ne60fn	262	14	in	in	IN
cord-321401-w4ne60fn	262	15	25	25	CD
cord-321401-w4ne60fn	262	16	RCTs	rct	NNS
cord-321401-w4ne60fn	262	17	(	(	-LRB-
cord-321401-w4ne60fn	262	18	11,321	11,321	CD
cord-321401-w4ne60fn	262	19	participants	participant	NNS
cord-321401-w4ne60fn	262	20	)	)	-RRB-
cord-321401-w4ne60fn	262	21	showed	show	VBD
cord-321401-w4ne60fn	262	22	that	that	IN
cord-321401-w4ne60fn	262	23	indeed	indeed	RB
cord-321401-w4ne60fn	262	24	vitamin	vitamin	NN
cord-321401-w4ne60fn	262	25	D	d	NN
cord-321401-w4ne60fn	262	26	supplementation	supplementation	NN
cord-321401-w4ne60fn	262	27	was	be	VBD
cord-321401-w4ne60fn	262	28	protective	protective	JJ
cord-321401-w4ne60fn	262	29	against	against	IN
cord-321401-w4ne60fn	262	30	ATRIs	atri	NNS
cord-321401-w4ne60fn	262	31	and	and	CC
cord-321401-w4ne60fn	262	32	this	this	DT
cord-321401-w4ne60fn	262	33	effect	effect	NN
cord-321401-w4ne60fn	262	34	was	be	VBD
cord-321401-w4ne60fn	262	35	again	again	RB
cord-321401-w4ne60fn	262	36	more	more	RBR
cord-321401-w4ne60fn	262	37	profound	profound	JJ
cord-321401-w4ne60fn	262	38	in	in	IN
cord-321401-w4ne60fn	262	39	patients	patient	NNS
cord-321401-w4ne60fn	262	40	with	with	IN
cord-321401-w4ne60fn	262	41	vitamin	vitamin	NN
cord-321401-w4ne60fn	262	42	D	d	NN
cord-321401-w4ne60fn	262	43	deficiency	deficiency	NN
cord-321401-w4ne60fn	263	1	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	263	2	<	<	XX
cord-321401-w4ne60fn	263	3	25	25	CD
cord-321401-w4ne60fn	263	4	nmol	nmol	NNP
cord-321401-w4ne60fn	263	5	/	/	SYM
cord-321401-w4ne60fn	263	6	L	l	NN
cord-321401-w4ne60fn	263	7	at	at	IN
cord-321401-w4ne60fn	263	8	baseline	baseline	NN
cord-321401-w4ne60fn	263	9	(	(	-LRB-
cord-321401-w4ne60fn	263	10	177	177	CD
cord-321401-w4ne60fn	263	11	)	)	-RRB-
cord-321401-w4ne60fn	263	12	.	.	.
cord-321401-w4ne60fn	264	1	A	a	DT
cord-321401-w4ne60fn	264	2	recent	recent	JJ
cord-321401-w4ne60fn	264	3	meta	meta	JJ
cord-321401-w4ne60fn	264	4	-	-	HYPH
cord-321401-w4ne60fn	264	5	analysis	analysis	NN
cord-321401-w4ne60fn	264	6	in	in	IN
cord-321401-w4ne60fn	264	7	asthma	asthma	NN
cord-321401-w4ne60fn	264	8	that	that	WDT
cord-321401-w4ne60fn	264	9	included	include	VBD
cord-321401-w4ne60fn	264	10	a	a	DT
cord-321401-w4ne60fn	264	11	total	total	NN
cord-321401-w4ne60fn	264	12	of	of	IN
cord-321401-w4ne60fn	264	13	14	14	CD
cord-321401-w4ne60fn	264	14	randomized	randomized	JJ
cord-321401-w4ne60fn	264	15	controlled	control	VBN
cord-321401-w4ne60fn	264	16	trials	trial	NNS
cord-321401-w4ne60fn	264	17	(	(	-LRB-
cord-321401-w4ne60fn	264	18	1,421	1,421	CD
cord-321401-w4ne60fn	264	19	participants	participant	NNS
cord-321401-w4ne60fn	264	20	)	)	-RRB-
cord-321401-w4ne60fn	264	21	,	,	,
cord-321401-w4ne60fn	264	22	indicated	indicate	VBD
cord-321401-w4ne60fn	264	23	that	that	IN
cord-321401-w4ne60fn	264	24	vitamin	vitamin	NN
cord-321401-w4ne60fn	264	25	D	D	NNP
cord-321401-w4ne60fn	264	26	supplementation	supplementation	NN
cord-321401-w4ne60fn	264	27	reduced	reduce	VBD
cord-321401-w4ne60fn	264	28	the	the	DT
cord-321401-w4ne60fn	264	29	rate	rate	NN
cord-321401-w4ne60fn	264	30	of	of	IN
cord-321401-w4ne60fn	264	31	asthma	asthma	NN
cord-321401-w4ne60fn	264	32	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	264	33	and	and	CC
cord-321401-w4ne60fn	264	34	increased	increase	VBN
cord-321401-w4ne60fn	264	35	lung	lung	NN
cord-321401-w4ne60fn	264	36	function	function	NN
cord-321401-w4ne60fn	264	37	,	,	,
cord-321401-w4ne60fn	264	38	especially	especially	RB
cord-321401-w4ne60fn	264	39	in	in	IN
cord-321401-w4ne60fn	264	40	patients	patient	NNS
cord-321401-w4ne60fn	264	41	with	with	IN
cord-321401-w4ne60fn	264	42	vitamin	vitamin	NN
cord-321401-w4ne60fn	264	43	D	d	NN
cord-321401-w4ne60fn	264	44	insufficiency	insufficiency	NN
cord-321401-w4ne60fn	264	45	(	(	-LRB-
cord-321401-w4ne60fn	264	46	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	264	47	<	<	XX
cord-321401-w4ne60fn	264	48	75	75	CD
cord-321401-w4ne60fn	264	49	nmol	nmol	NNP
cord-321401-w4ne60fn	264	50	/	/	SYM
cord-321401-w4ne60fn	264	51	L	l	NN
cord-321401-w4ne60fn	264	52	)	)	-RRB-
cord-321401-w4ne60fn	264	53	(	(	-LRB-
cord-321401-w4ne60fn	264	54	178	178	CD
cord-321401-w4ne60fn	264	55	)	)	-RRB-
cord-321401-w4ne60fn	264	56	.	.	.
cord-321401-w4ne60fn	265	1	Interestingly	interestingly	RB
cord-321401-w4ne60fn	265	2	,	,	,
cord-321401-w4ne60fn	265	3	in	in	IN
cord-321401-w4ne60fn	265	4	asthma	asthma	NN
cord-321401-w4ne60fn	265	5	patients	patient	NNS
cord-321401-w4ne60fn	265	6	that	that	WDT
cord-321401-w4ne60fn	265	7	were	be	VBD
cord-321401-w4ne60fn	265	8	supplemented	supplement	VBN
cord-321401-w4ne60fn	265	9	with	with	IN
cord-321401-w4ne60fn	265	10	vitamin	vitamin	NN
cord-321401-w4ne60fn	265	11	D	d	NN
cord-321401-w4ne60fn	265	12	,	,	,
cord-321401-w4ne60fn	265	13	the	the	DT
cord-321401-w4ne60fn	265	14	frequency	frequency	NN
cord-321401-w4ne60fn	265	15	of	of	IN
cord-321401-w4ne60fn	265	16	respiratory	respiratory	JJ
cord-321401-w4ne60fn	265	17	infections	infection	NNS
cord-321401-w4ne60fn	265	18	was	be	VBD
cord-321401-w4ne60fn	265	19	reduced	reduce	VBN
cord-321401-w4ne60fn	265	20	,	,	,
cord-321401-w4ne60fn	265	21	and	and	CC
cord-321401-w4ne60fn	265	22	this	this	DT
cord-321401-w4ne60fn	265	23	effect	effect	NN
cord-321401-w4ne60fn	265	24	was	be	VBD
cord-321401-w4ne60fn	265	25	related	relate	VBN
cord-321401-w4ne60fn	265	26	to	to	IN
cord-321401-w4ne60fn	265	27	the	the	DT
cord-321401-w4ne60fn	265	28	increase	increase	NN
cord-321401-w4ne60fn	265	29	of	of	IN
cord-321401-w4ne60fn	265	30	hCAP18	hCAP18	NNP
cord-321401-w4ne60fn	265	31	/	/	SYM
cord-321401-w4ne60fn	265	32	LL-37	LL-37	NNP
cord-321401-w4ne60fn	265	33	(	(	-LRB-
cord-321401-w4ne60fn	265	34	179	179	CD
cord-321401-w4ne60fn	265	35	)	)	-RRB-
cord-321401-w4ne60fn	265	36	.	.	.
cord-321401-w4ne60fn	266	1	CF	CF	NNP
cord-321401-w4ne60fn	266	2	patients	patient	NNS
cord-321401-w4ne60fn	266	3	with	with	IN
cord-321401-w4ne60fn	266	4	vitamin	vitamin	NN
cord-321401-w4ne60fn	266	5	D	D	NNP
cord-321401-w4ne60fn	266	6	deficiency	deficiency	NN
cord-321401-w4ne60fn	266	7	had	have	VBD
cord-321401-w4ne60fn	266	8	a	a	DT
cord-321401-w4ne60fn	266	9	higher	high	JJR
cord-321401-w4ne60fn	266	10	rate	rate	NN
cord-321401-w4ne60fn	266	11	of	of	IN
cord-321401-w4ne60fn	266	12	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	266	13	as	as	IN
cord-321401-w4ne60fn	266	14	compared	compare	VBN
cord-321401-w4ne60fn	266	15	to	to	IN
cord-321401-w4ne60fn	266	16	patients	patient	NNS
cord-321401-w4ne60fn	266	17	with	with	IN
cord-321401-w4ne60fn	266	18	sufficient	sufficient	JJ
cord-321401-w4ne60fn	266	19	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	266	20	levels	level	NNS
cord-321401-w4ne60fn	266	21	(	(	-LRB-
cord-321401-w4ne60fn	266	22	180	180	CD
cord-321401-w4ne60fn	266	23	)	)	-RRB-
cord-321401-w4ne60fn	266	24	.	.	.
cord-321401-w4ne60fn	267	1	However	however	RB
cord-321401-w4ne60fn	267	2	,	,	,
cord-321401-w4ne60fn	267	3	only	only	RB
cord-321401-w4ne60fn	267	4	one	one	CD
cord-321401-w4ne60fn	267	5	recent	recent	JJ
cord-321401-w4ne60fn	267	6	multicenter	multicenter	JJ
cord-321401-w4ne60fn	267	7	RCT	RCT	NNP
cord-321401-w4ne60fn	267	8	was	be	VBD
cord-321401-w4ne60fn	267	9	conducted	conduct	VBN
cord-321401-w4ne60fn	267	10	and	and	CC
cord-321401-w4ne60fn	267	11	indicated	indicate	VBD
cord-321401-w4ne60fn	267	12	that	that	IN
cord-321401-w4ne60fn	267	13	vitamin	vitamin	NN
cord-321401-w4ne60fn	267	14	D	D	NNP
cord-321401-w4ne60fn	267	15	supplementation	supplementation	NN
cord-321401-w4ne60fn	267	16	did	do	VBD
cord-321401-w4ne60fn	267	17	not	not	RB
cord-321401-w4ne60fn	267	18	affect	affect	VB
cord-321401-w4ne60fn	267	19	the	the	DT
cord-321401-w4ne60fn	267	20	number	number	NN
cord-321401-w4ne60fn	267	21	of	of	IN
cord-321401-w4ne60fn	267	22	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	267	23	in	in	IN
cord-321401-w4ne60fn	267	24	CF	CF	NNP
cord-321401-w4ne60fn	267	25	patients	patient	NNS
cord-321401-w4ne60fn	267	26	with	with	IN
cord-321401-w4ne60fn	267	27	serum	serum	NN
cord-321401-w4ne60fn	267	28	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	267	29	concentrations	concentration	NNS
cord-321401-w4ne60fn	267	30	between	between	IN
cord-321401-w4ne60fn	267	31	25	25	CD
cord-321401-w4ne60fn	267	32	and	and	CC
cord-321401-w4ne60fn	267	33	137.5	137.5	CD
cord-321401-w4ne60fn	267	34	nmol	nmol	JJ
cord-321401-w4ne60fn	267	35	/	/	SYM
cord-321401-w4ne60fn	267	36	L	l	NN
cord-321401-w4ne60fn	267	37	(	(	-LRB-
cord-321401-w4ne60fn	267	38	181	181	CD
cord-321401-w4ne60fn	267	39	)	)	-RRB-
cord-321401-w4ne60fn	267	40	.	.	.
cord-321401-w4ne60fn	268	1	In	in	IN
cord-321401-w4ne60fn	268	2	summary	summary	NN
cord-321401-w4ne60fn	268	3	,	,	,
cord-321401-w4ne60fn	268	4	the	the	DT
cord-321401-w4ne60fn	268	5	protective	protective	JJ
cord-321401-w4ne60fn	268	6	effects	effect	NNS
cord-321401-w4ne60fn	268	7	of	of	IN
cord-321401-w4ne60fn	268	8	vitamin	vitamin	NN
cord-321401-w4ne60fn	268	9	D	d	NN
cord-321401-w4ne60fn	268	10	supplementation	supplementation	NN
cord-321401-w4ne60fn	268	11	in	in	IN
cord-321401-w4ne60fn	268	12	patients	patient	NNS
cord-321401-w4ne60fn	268	13	suffering	suffer	VBG
cord-321401-w4ne60fn	268	14	from	from	IN
cord-321401-w4ne60fn	268	15	COPD	COPD	NNP
cord-321401-w4ne60fn	268	16	,	,	,
cord-321401-w4ne60fn	268	17	asthma	asthma	NN
cord-321401-w4ne60fn	268	18	or	or	CC
cord-321401-w4ne60fn	268	19	ARTIs	arti	NNS
cord-321401-w4ne60fn	268	20	are	be	VBP
cord-321401-w4ne60fn	268	21	most	most	RBS
cord-321401-w4ne60fn	268	22	prominent	prominent	JJ
cord-321401-w4ne60fn	268	23	in	in	IN
cord-321401-w4ne60fn	268	24	those	those	DT
cord-321401-w4ne60fn	268	25	with	with	IN
cord-321401-w4ne60fn	268	26	vitamin	vitamin	NN
cord-321401-w4ne60fn	268	27	D	d	NN
cord-321401-w4ne60fn	268	28	deficiency	deficiency	NN
cord-321401-w4ne60fn	268	29	and	and	CC
cord-321401-w4ne60fn	268	30	this	this	DT
cord-321401-w4ne60fn	268	31	would	would	MD
cord-321401-w4ne60fn	268	32	indicate	indicate	VB
cord-321401-w4ne60fn	268	33	the	the	DT
cord-321401-w4ne60fn	268	34	importance	importance	NN
cord-321401-w4ne60fn	268	35	of	of	IN
cord-321401-w4ne60fn	268	36	establishing	establish	VBG
cord-321401-w4ne60fn	268	37	serum	serum	NN
cord-321401-w4ne60fn	268	38	levels	level	NNS
cord-321401-w4ne60fn	268	39	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	268	40	in	in	IN
cord-321401-w4ne60fn	268	41	these	these	DT
cord-321401-w4ne60fn	268	42	patients	patient	NNS
cord-321401-w4ne60fn	268	43	as	as	IN
cord-321401-w4ne60fn	268	44	supplementation	supplementation	NN
cord-321401-w4ne60fn	268	45	could	could	MD
cord-321401-w4ne60fn	268	46	reduce	reduce	VB
cord-321401-w4ne60fn	268	47	unnecessary	unnecessary	JJ
cord-321401-w4ne60fn	268	48	aggravated	aggravated	JJ
cord-321401-w4ne60fn	268	49	disease	disease	NN
cord-321401-w4ne60fn	268	50	pathology	pathology	NN
cord-321401-w4ne60fn	268	51	as	as	IN
cord-321401-w4ne60fn	268	52	a	a	DT
cord-321401-w4ne60fn	268	53	result	result	NN
cord-321401-w4ne60fn	268	54	of	of	IN
cord-321401-w4ne60fn	268	55	this	this	DT
cord-321401-w4ne60fn	268	56	deficiency	deficiency	NN
cord-321401-w4ne60fn	268	57	.	.	.
cord-321401-w4ne60fn	269	1	Many	many	JJ
cord-321401-w4ne60fn	269	2	drivers	driver	NNS
cord-321401-w4ne60fn	269	3	of	of	IN
cord-321401-w4ne60fn	269	4	COPD	COPD	NNP
cord-321401-w4ne60fn	269	5	pathogenesis	pathogenesis	NN
cord-321401-w4ne60fn	269	6	such	such	JJ
cord-321401-w4ne60fn	269	7	as	as	IN
cord-321401-w4ne60fn	269	8	chronic	chronic	JJ
cord-321401-w4ne60fn	269	9	exposure	exposure	NN
cord-321401-w4ne60fn	269	10	to	to	IN
cord-321401-w4ne60fn	269	11	noxious	noxious	JJ
cord-321401-w4ne60fn	269	12	particles	particle	NNS
cord-321401-w4ne60fn	269	13	and	and	CC
cord-321401-w4ne60fn	269	14	gases	gas	NNS
cord-321401-w4ne60fn	269	15	,	,	,
cord-321401-w4ne60fn	269	16	which	which	WDT
cord-321401-w4ne60fn	269	17	are	be	VBP
cord-321401-w4ne60fn	269	18	present	present	JJ
cord-321401-w4ne60fn	269	19	in	in	IN
cord-321401-w4ne60fn	269	20	CS	CS	NNP
cord-321401-w4ne60fn	269	21	and	and	CC
cord-321401-w4ne60fn	269	22	air	air	NN
cord-321401-w4ne60fn	269	23	pollution	pollution	NN
cord-321401-w4ne60fn	269	24	,	,	,
cord-321401-w4ne60fn	269	25	proteolytic	proteolytic	JJ
cord-321401-w4ne60fn	269	26	enzymes	enzyme	NNS
cord-321401-w4ne60fn	269	27	,	,	,
cord-321401-w4ne60fn	269	28	cytokines	cytokine	NNS
cord-321401-w4ne60fn	269	29	and	and	CC
cord-321401-w4ne60fn	269	30	chemokines	chemokine	NNS
cord-321401-w4ne60fn	269	31	that	that	WDT
cord-321401-w4ne60fn	269	32	are	be	VBP
cord-321401-w4ne60fn	269	33	released	release	VBN
cord-321401-w4ne60fn	269	34	by	by	IN
cord-321401-w4ne60fn	269	35	infiltrating	infiltrate	VBG
cord-321401-w4ne60fn	269	36	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	269	37	cells	cell	NNS
cord-321401-w4ne60fn	269	38	,	,	,
cord-321401-w4ne60fn	269	39	are	be	VBP
cord-321401-w4ne60fn	269	40	known	know	VBN
cord-321401-w4ne60fn	269	41	to	to	TO
cord-321401-w4ne60fn	269	42	harm	harm	VB
cord-321401-w4ne60fn	269	43	the	the	DT
cord-321401-w4ne60fn	269	44	epithelial	epithelial	JJ
cord-321401-w4ne60fn	269	45	barrier	barrier	NN
cord-321401-w4ne60fn	269	46	and	and	CC
cord-321401-w4ne60fn	269	47	cause	cause	VB
cord-321401-w4ne60fn	269	48	aberrant	aberrant	JJ
cord-321401-w4ne60fn	269	49	remodeling	remodeling	NN
cord-321401-w4ne60fn	269	50	of	of	IN
cord-321401-w4ne60fn	269	51	the	the	DT
cord-321401-w4ne60fn	269	52	airway	airway	NN
cord-321401-w4ne60fn	269	53	epithelium	epithelium	NN
cord-321401-w4ne60fn	269	54	with	with	IN
cord-321401-w4ne60fn	269	55	important	important	JJ
cord-321401-w4ne60fn	269	56	functional	functional	JJ
cord-321401-w4ne60fn	269	57	consequences	consequence	NNS
cord-321401-w4ne60fn	269	58	for	for	IN
cord-321401-w4ne60fn	269	59	e.g.	e.g.	RB
cord-321401-w4ne60fn	269	60	,	,	,
cord-321401-w4ne60fn	269	61	host	host	NN
cord-321401-w4ne60fn	269	62	defense	defense	NN
cord-321401-w4ne60fn	269	63	.	.	.
cord-321401-w4ne60fn	270	1	A	a	DT
cord-321401-w4ne60fn	270	2	dysfunctional	dysfunctional	JJ
cord-321401-w4ne60fn	270	3	epithelial	epithelial	JJ
cord-321401-w4ne60fn	270	4	barrier	barrier	NN
cord-321401-w4ne60fn	270	5	increases	increase	VBZ
cord-321401-w4ne60fn	270	6	the	the	DT
cord-321401-w4ne60fn	270	7	susceptibility	susceptibility	NN
cord-321401-w4ne60fn	270	8	toward	toward	IN
cord-321401-w4ne60fn	270	9	bacterial	bacterial	JJ
cord-321401-w4ne60fn	270	10	and	and	CC
cord-321401-w4ne60fn	270	11	viral	viral	JJ
cord-321401-w4ne60fn	270	12	infections	infection	NNS
cord-321401-w4ne60fn	270	13	,	,	,
cord-321401-w4ne60fn	270	14	which	which	WDT
cord-321401-w4ne60fn	270	15	are	be	VBP
cord-321401-w4ne60fn	270	16	important	important	JJ
cord-321401-w4ne60fn	270	17	triggers	trigger	NNS
cord-321401-w4ne60fn	270	18	of	of	IN
cord-321401-w4ne60fn	270	19	COPD	COPD	NNP
cord-321401-w4ne60fn	270	20	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	270	21	and	and	CC
cord-321401-w4ne60fn	270	22	these	these	DT
cord-321401-w4ne60fn	270	23	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	270	24	contribute	contribute	VBP
cord-321401-w4ne60fn	270	25	importantly	importantly	RB
cord-321401-w4ne60fn	270	26	to	to	IN
cord-321401-w4ne60fn	270	27	disease	disease	NN
cord-321401-w4ne60fn	270	28	progression	progression	NN
cord-321401-w4ne60fn	270	29	.	.	.
cord-321401-w4ne60fn	271	1	Sufficient	sufficient	JJ
cord-321401-w4ne60fn	271	2	local	local	JJ
cord-321401-w4ne60fn	271	3	levels	level	NNS
cord-321401-w4ne60fn	271	4	of	of	IN
cord-321401-w4ne60fn	271	5	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	271	6	)	)	-RRB-
cord-321401-w4ne60fn	271	7	2	2	CD
cord-321401-w4ne60fn	271	8	D	d	NN
cord-321401-w4ne60fn	271	9	may	may	MD
cord-321401-w4ne60fn	271	10	provide	provide	VB
cord-321401-w4ne60fn	271	11	partial	partial	JJ
cord-321401-w4ne60fn	271	12	protection	protection	NN
cord-321401-w4ne60fn	271	13	against	against	IN
cord-321401-w4ne60fn	271	14	these	these	DT
cord-321401-w4ne60fn	271	15	effects	effect	NNS
cord-321401-w4ne60fn	271	16	by	by	IN
cord-321401-w4ne60fn	271	17	reducing	reduce	VBG
cord-321401-w4ne60fn	271	18	the	the	DT
cord-321401-w4ne60fn	271	19	effects	effect	NNS
cord-321401-w4ne60fn	271	20	of	of	IN
cord-321401-w4ne60fn	271	21	oxidative	oxidative	JJ
cord-321401-w4ne60fn	271	22	stress	stress	NN
cord-321401-w4ne60fn	271	23	induced	induce	VBN
cord-321401-w4ne60fn	271	24	by	by	IN
cord-321401-w4ne60fn	271	25	exposure	exposure	NN
cord-321401-w4ne60fn	271	26	to	to	IN
cord-321401-w4ne60fn	271	27	inhaled	inhale	VBN
cord-321401-w4ne60fn	271	28	oxidants	oxidant	NNS
cord-321401-w4ne60fn	271	29	or	or	CC
cord-321401-w4ne60fn	271	30	those	those	DT
cord-321401-w4ne60fn	271	31	derived	derive	VBN
cord-321401-w4ne60fn	271	32	from	from	IN
cord-321401-w4ne60fn	271	33	recruited	recruit	VBN
cord-321401-w4ne60fn	271	34	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	271	35	cells	cell	NNS
cord-321401-w4ne60fn	271	36	.	.	.
cord-321401-w4ne60fn	272	1	1,25(OH	1,25(oh	LS
cord-321401-w4ne60fn	272	2	)	)	-RRB-
cord-321401-w4ne60fn	272	3	2	2	CD
cord-321401-w4ne60fn	272	4	D	d	NN
cord-321401-w4ne60fn	272	5	furthermore	furthermore	RB
cord-321401-w4ne60fn	272	6	protects	protect	VBZ
cord-321401-w4ne60fn	272	7	against	against	IN
cord-321401-w4ne60fn	272	8	impairment	impairment	NN
cord-321401-w4ne60fn	272	9	of	of	IN
cord-321401-w4ne60fn	272	10	epithelial	epithelial	JJ
cord-321401-w4ne60fn	272	11	barrier	barrier	NN
cord-321401-w4ne60fn	272	12	function	function	NN
cord-321401-w4ne60fn	272	13	by	by	IN
cord-321401-w4ne60fn	272	14	promoting	promote	VBG
cord-321401-w4ne60fn	272	15	the	the	DT
cord-321401-w4ne60fn	272	16	integrity	integrity	NN
cord-321401-w4ne60fn	272	17	of	of	IN
cord-321401-w4ne60fn	272	18	the	the	DT
cord-321401-w4ne60fn	272	19	epithelial	epithelial	JJ
cord-321401-w4ne60fn	272	20	barrier	barrier	NN
cord-321401-w4ne60fn	272	21	,	,	,
cord-321401-w4ne60fn	272	22	and	and	CC
cord-321401-w4ne60fn	272	23	by	by	IN
cord-321401-w4ne60fn	272	24	modulating	modulate	VBG
cord-321401-w4ne60fn	272	25	both	both	DT
cord-321401-w4ne60fn	272	26	innate	innate	JJ
cord-321401-w4ne60fn	272	27	and	and	CC
cord-321401-w4ne60fn	272	28	adaptive	adaptive	JJ
cord-321401-w4ne60fn	272	29	immune	immune	JJ
cord-321401-w4ne60fn	272	30	responses	response	NNS
cord-321401-w4ne60fn	272	31	.	.	.
cord-321401-w4ne60fn	273	1	Protection	protection	NN
cord-321401-w4ne60fn	273	2	against	against	IN
cord-321401-w4ne60fn	273	3	the	the	DT
cord-321401-w4ne60fn	273	4	detrimental	detrimental	JJ
cord-321401-w4ne60fn	273	5	effects	effect	NNS
cord-321401-w4ne60fn	273	6	of	of	IN
cord-321401-w4ne60fn	273	7	both	both	DT
cord-321401-w4ne60fn	273	8	bacterial	bacterial	JJ
cord-321401-w4ne60fn	273	9	and	and	CC
cord-321401-w4ne60fn	273	10	viral	viral	JJ
cord-321401-w4ne60fn	273	11	infections	infection	NNS
cord-321401-w4ne60fn	273	12	is	be	VBZ
cord-321401-w4ne60fn	273	13	provided	provide	VBN
cord-321401-w4ne60fn	273	14	by	by	IN
cord-321401-w4ne60fn	273	15	the	the	DT
cord-321401-w4ne60fn	273	16	ability	ability	NN
cord-321401-w4ne60fn	273	17	of	of	IN
cord-321401-w4ne60fn	273	18	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	273	19	)	)	-RRB-
cord-321401-w4ne60fn	273	20	2	2	CD
cord-321401-w4ne60fn	273	21	D	d	NN
cord-321401-w4ne60fn	273	22	to	to	TO
cord-321401-w4ne60fn	273	23	promote	promote	VB
cord-321401-w4ne60fn	273	24	of	of	IN
cord-321401-w4ne60fn	273	25	antiviral	antiviral	JJ
cord-321401-w4ne60fn	273	26	responses	response	NNS
cord-321401-w4ne60fn	273	27	,	,	,
cord-321401-w4ne60fn	273	28	induce	induce	VB
cord-321401-w4ne60fn	273	29	expression	expression	NN
cord-321401-w4ne60fn	273	30	of	of	IN
cord-321401-w4ne60fn	273	31	AMPs	amp	NNS
cord-321401-w4ne60fn	273	32	and	and	CC
cord-321401-w4ne60fn	273	33	modulate	modulate	VBP
cord-321401-w4ne60fn	273	34	of	of	IN
cord-321401-w4ne60fn	273	35	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	273	36	responses	response	NNS
cord-321401-w4ne60fn	273	37	.	.	.
cord-321401-w4ne60fn	274	1	Taken	take	VBN
cord-321401-w4ne60fn	274	2	together	together	RB
cord-321401-w4ne60fn	274	3	,	,	,
cord-321401-w4ne60fn	274	4	these	these	DT
cord-321401-w4ne60fn	274	5	activities	activity	NNS
cord-321401-w4ne60fn	274	6	suggest	suggest	VBP
cord-321401-w4ne60fn	274	7	that	that	IN
cord-321401-w4ne60fn	274	8	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	274	9	)	)	-RRB-
cord-321401-w4ne60fn	274	10	2	2	CD
cord-321401-w4ne60fn	274	11	D	d	NN
cord-321401-w4ne60fn	274	12	may	may	MD
cord-321401-w4ne60fn	274	13	provide	provide	VB
cord-321401-w4ne60fn	274	14	protection	protection	NN
cord-321401-w4ne60fn	274	15	against	against	IN
cord-321401-w4ne60fn	274	16	development	development	NN
cord-321401-w4ne60fn	274	17	and	and	CC
cord-321401-w4ne60fn	274	18	progression	progression	NN
cord-321401-w4ne60fn	274	19	of	of	IN
cord-321401-w4ne60fn	274	20	COPD	COPD	NNP
cord-321401-w4ne60fn	274	21	,	,	,
cord-321401-w4ne60fn	274	22	and	and	CC
cord-321401-w4ne60fn	274	23	against	against	IN
cord-321401-w4ne60fn	274	24	disease	disease	NN
cord-321401-w4ne60fn	274	25	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	274	26	.	.	.
cord-321401-w4ne60fn	275	1	In	in	IN
cord-321401-w4ne60fn	275	2	addition	addition	NN
cord-321401-w4ne60fn	275	3	,	,	,
cord-321401-w4ne60fn	275	4	the	the	DT
cord-321401-w4ne60fn	275	5	local	local	JJ
cord-321401-w4ne60fn	275	6	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	275	7	milieu	milieu	NN
cord-321401-w4ne60fn	275	8	as	as	RB
cord-321401-w4ne60fn	275	9	well	well	RB
cord-321401-w4ne60fn	275	10	as	as	IN
cord-321401-w4ne60fn	275	11	the	the	DT
cord-321401-w4ne60fn	275	12	chronic	chronic	JJ
cord-321401-w4ne60fn	275	13	exposure	exposure	NN
cord-321401-w4ne60fn	275	14	to	to	IN
cord-321401-w4ne60fn	275	15	noxious	noxious	JJ
cord-321401-w4ne60fn	275	16	particles	particle	NNS
cord-321401-w4ne60fn	275	17	and	and	CC
cord-321401-w4ne60fn	275	18	gases	gas	NNS
cord-321401-w4ne60fn	275	19	,	,	,
cord-321401-w4ne60fn	275	20	which	which	WDT
cord-321401-w4ne60fn	275	21	are	be	VBP
cord-321401-w4ne60fn	275	22	present	present	JJ
cord-321401-w4ne60fn	275	23	in	in	IN
cord-321401-w4ne60fn	275	24	CS	CS	NNP
cord-321401-w4ne60fn	275	25	and	and	CC
cord-321401-w4ne60fn	275	26	air	air	NN
cord-321401-w4ne60fn	275	27	pollution	pollution	NN
cord-321401-w4ne60fn	275	28	,	,	,
cord-321401-w4ne60fn	275	29	may	may	MD
cord-321401-w4ne60fn	275	30	negatively	negatively	RB
cord-321401-w4ne60fn	275	31	affect	affect	VB
cord-321401-w4ne60fn	275	32	synthesis	synthesis	NN
cord-321401-w4ne60fn	275	33	and	and	CC
cord-321401-w4ne60fn	275	34	signaling	signaling	NN
cord-321401-w4ne60fn	275	35	of	of	IN
cord-321401-w4ne60fn	275	36	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	275	37	)	)	-RRB-
cord-321401-w4ne60fn	275	38	2	2	CD
cord-321401-w4ne60fn	275	39	D.	D.	NNP
cord-321401-w4ne60fn	275	40	Here	here	RB
cord-321401-w4ne60fn	275	41	we	-PRON-	PRP
cord-321401-w4ne60fn	275	42	discussed	discuss	VBD
cord-321401-w4ne60fn	275	43	recent	recent	JJ
cord-321401-w4ne60fn	275	44	in	in	IN
cord-321401-w4ne60fn	275	45	vitro	vitro	FW
cord-321401-w4ne60fn	275	46	studies	study	NNS
cord-321401-w4ne60fn	275	47	that	that	WDT
cord-321401-w4ne60fn	275	48	demonstrated	demonstrate	VBD
cord-321401-w4ne60fn	275	49	that	that	IN
cord-321401-w4ne60fn	275	50	disease	disease	NN
cord-321401-w4ne60fn	275	51	-	-	HYPH
cord-321401-w4ne60fn	275	52	associated	associate	VBN
cord-321401-w4ne60fn	275	53	factors	factor	NNS
cord-321401-w4ne60fn	275	54	such	such	JJ
cord-321401-w4ne60fn	275	55	as	as	IN
cord-321401-w4ne60fn	275	56	inflammation	inflammation	NN
cord-321401-w4ne60fn	275	57	and	and	CC
cord-321401-w4ne60fn	275	58	exposure	exposure	NN
cord-321401-w4ne60fn	275	59	to	to	IN
cord-321401-w4ne60fn	275	60	CS	CS	NNP
cord-321401-w4ne60fn	275	61	and	and	CC
cord-321401-w4ne60fn	275	62	air	air	NN
cord-321401-w4ne60fn	275	63	pollution	pollution	NN
cord-321401-w4ne60fn	275	64	could	could	MD
cord-321401-w4ne60fn	275	65	interfere	interfere	VB
cord-321401-w4ne60fn	275	66	with	with	IN
cord-321401-w4ne60fn	275	67	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	275	68	)	)	-RRB-
cord-321401-w4ne60fn	275	69	2	2	CD
cord-321401-w4ne60fn	275	70	D	d	NN
cord-321401-w4ne60fn	275	71	signaling	signaling	NN
cord-321401-w4ne60fn	275	72	and	and	CC
cord-321401-w4ne60fn	275	73	its	-PRON-	PRP$
cord-321401-w4ne60fn	275	74	degradation	degradation	NN
cord-321401-w4ne60fn	275	75	and	and	CC
cord-321401-w4ne60fn	275	76	activation	activation	NN
cord-321401-w4ne60fn	275	77	by	by	IN
cord-321401-w4ne60fn	275	78	affecting	affect	VBG
cord-321401-w4ne60fn	275	79	expression	expression	NN
cord-321401-w4ne60fn	275	80	of	of	IN
cord-321401-w4ne60fn	275	81	VDR	VDR	NNP
cord-321401-w4ne60fn	275	82	,	,	,
cord-321401-w4ne60fn	275	83	CYP24A1	CYP24A1	NNP
cord-321401-w4ne60fn	275	84	and	and	CC
cord-321401-w4ne60fn	275	85	CYP27B1	cyp27b1	NN
cord-321401-w4ne60fn	275	86	,	,	,
cord-321401-w4ne60fn	275	87	respectively	respectively	RB
cord-321401-w4ne60fn	275	88	.	.	.
cord-321401-w4ne60fn	276	1	These	these	DT
cord-321401-w4ne60fn	276	2	findings	finding	NNS
cord-321401-w4ne60fn	276	3	indicate	indicate	VBP
cord-321401-w4ne60fn	276	4	that	that	IN
cord-321401-w4ne60fn	276	5	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	276	6	)	)	-RRB-
cord-321401-w4ne60fn	276	7	2	2	CD
cord-321401-w4ne60fn	276	8	D	d	NN
cord-321401-w4ne60fn	276	9	levels	level	NNS
cord-321401-w4ne60fn	276	10	and	and	CC
cord-321401-w4ne60fn	276	11	its	-PRON-	PRP$
cord-321401-w4ne60fn	276	12	activities	activity	NNS
cord-321401-w4ne60fn	276	13	on	on	IN
cord-321401-w4ne60fn	276	14	airway	airway	NN
cord-321401-w4ne60fn	276	15	mucosa	mucosa	NN
cord-321401-w4ne60fn	276	16	might	may	MD
cord-321401-w4ne60fn	276	17	be	be	VB
cord-321401-w4ne60fn	276	18	impaired	impair	VBN
cord-321401-w4ne60fn	276	19	especially	especially	RB
cord-321401-w4ne60fn	276	20	in	in	IN
cord-321401-w4ne60fn	276	21	patients	patient	NNS
cord-321401-w4ne60fn	276	22	with	with	IN
cord-321401-w4ne60fn	276	23	COPD	COPD	NNP
cord-321401-w4ne60fn	276	24	with	with	IN
cord-321401-w4ne60fn	276	25	exposures	exposure	NNS
cord-321401-w4ne60fn	276	26	to	to	TO
cord-321401-w4ne60fn	276	27	cigarette	cigarette	NN
cord-321401-w4ne60fn	276	28	smoke	smoke	NN
cord-321401-w4ne60fn	276	29	and	and	CC
cord-321401-w4ne60fn	276	30	cytokines	cytokine	NNS
cord-321401-w4ne60fn	276	31	such	such	JJ
cord-321401-w4ne60fn	276	32	as	as	IN
cord-321401-w4ne60fn	276	33	TNF	TNF	NNP
cord-321401-w4ne60fn	276	34	-	-	HYPH
cord-321401-w4ne60fn	276	35	α	α	NNP
cord-321401-w4ne60fn	276	36	,	,	,
cord-321401-w4ne60fn	276	37	IL-1β	IL-1β	NNP
cord-321401-w4ne60fn	276	38	,	,	,
cord-321401-w4ne60fn	276	39	IL-17A	IL-17A	NNP
cord-321401-w4ne60fn	276	40	and	and	CC
cord-321401-w4ne60fn	276	41	TGF	TGF	NNP
cord-321401-w4ne60fn	276	42	-	-	HYPH
cord-321401-w4ne60fn	276	43	β1	β1	NNP
cord-321401-w4ne60fn	276	44	.	.	.
cord-321401-w4ne60fn	277	1	This	this	DT
cord-321401-w4ne60fn	277	2	suggests	suggest	VBZ
cord-321401-w4ne60fn	277	3	that	that	IN
cord-321401-w4ne60fn	277	4	even	even	RB
cord-321401-w4ne60fn	277	5	in	in	IN
cord-321401-w4ne60fn	277	6	patients	patient	NNS
cord-321401-w4ne60fn	277	7	with	with	IN
cord-321401-w4ne60fn	277	8	sufficient	sufficient	JJ
cord-321401-w4ne60fn	277	9	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	277	10	serum	serum	NN
cord-321401-w4ne60fn	277	11	levels	level	NNS
cord-321401-w4ne60fn	277	12	the	the	DT
cord-321401-w4ne60fn	277	13	local	local	JJ
cord-321401-w4ne60fn	277	14	activity	activity	NN
cord-321401-w4ne60fn	277	15	of	of	IN
cord-321401-w4ne60fn	277	16	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	277	17	)	)	-RRB-
cord-321401-w4ne60fn	277	18	2	2	CD
cord-321401-w4ne60fn	277	19	D	d	NN
cord-321401-w4ne60fn	277	20	in	in	IN
cord-321401-w4ne60fn	277	21	the	the	DT
cord-321401-w4ne60fn	277	22	lungs	lung	NNS
cord-321401-w4ne60fn	277	23	can	can	MD
cord-321401-w4ne60fn	277	24	be	be	VB
cord-321401-w4ne60fn	277	25	improved	improve	VBN
cord-321401-w4ne60fn	277	26	.	.	.
cord-321401-w4ne60fn	278	1	We	-PRON-	PRP
cord-321401-w4ne60fn	278	2	have	have	VBP
cord-321401-w4ne60fn	278	3	to	to	TO
cord-321401-w4ne60fn	278	4	start	start	VB
cord-321401-w4ne60fn	278	5	generating	generate	VBG
cord-321401-w4ne60fn	278	6	more	more	JJR
cord-321401-w4ne60fn	278	7	information	information	NN
cord-321401-w4ne60fn	278	8	on	on	IN
cord-321401-w4ne60fn	278	9	both	both	CC
cord-321401-w4ne60fn	278	10	systemic	systemic	JJ
cord-321401-w4ne60fn	278	11	and	and	CC
cord-321401-w4ne60fn	278	12	local	local	JJ
cord-321401-w4ne60fn	278	13	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	278	14	)	)	-RRB-
cord-321401-w4ne60fn	278	15	2	2	CD
cord-321401-w4ne60fn	278	16	D	d	NN
cord-321401-w4ne60fn	278	17	levels	level	NNS
cord-321401-w4ne60fn	278	18	and	and	CC
cord-321401-w4ne60fn	278	19	gene	gene	NN
cord-321401-w4ne60fn	278	20	expression	expression	NN
cord-321401-w4ne60fn	278	21	signatures	signature	NNS
cord-321401-w4ne60fn	278	22	related	relate	VBN
cord-321401-w4ne60fn	278	23	to	to	IN
cord-321401-w4ne60fn	278	24	25(OH)D	25(oh)d	CD
cord-321401-w4ne60fn	278	25	and	and	CC
cord-321401-w4ne60fn	278	26	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	278	27	)	)	-RRB-
cord-321401-w4ne60fn	278	28	2	2	CD
cord-321401-w4ne60fn	278	29	D	d	NN
cord-321401-w4ne60fn	278	30	metabolism	metabolism	NN
cord-321401-w4ne60fn	278	31	or	or	CC
cord-321401-w4ne60fn	278	32	responses	response	NNS
cord-321401-w4ne60fn	278	33	in	in	IN
cord-321401-w4ne60fn	278	34	COPD	COPD	NNP
cord-321401-w4ne60fn	278	35	(	(	-LRB-
cord-321401-w4ne60fn	278	36	and	and	CC
cord-321401-w4ne60fn	278	37	other	other	JJ
cord-321401-w4ne60fn	278	38	chronic	chronic	JJ
cord-321401-w4ne60fn	278	39	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	278	40	diseases	disease	NNS
cord-321401-w4ne60fn	278	41	that	that	WDT
cord-321401-w4ne60fn	278	42	are	be	VBP
cord-321401-w4ne60fn	278	43	related	relate	VBN
cord-321401-w4ne60fn	278	44	to	to	IN
cord-321401-w4ne60fn	278	45	vitamin	vitamin	NN
cord-321401-w4ne60fn	278	46	D	D	NNP
cord-321401-w4ne60fn	278	47	deficiency	deficiency	NN
cord-321401-w4ne60fn	278	48	)	)	-RRB-
cord-321401-w4ne60fn	278	49	,	,	,
cord-321401-w4ne60fn	278	50	both	both	CC
cord-321401-w4ne60fn	278	51	at	at	IN
cord-321401-w4ne60fn	278	52	baseline	baseline	NN
cord-321401-w4ne60fn	278	53	and	and	CC
cord-321401-w4ne60fn	278	54	after	after	IN
cord-321401-w4ne60fn	278	55	vitamin	vitamin	NN
cord-321401-w4ne60fn	278	56	D	d	NN
cord-321401-w4ne60fn	278	57	supplementation	supplementation	NN
cord-321401-w4ne60fn	278	58	.	.	.
cord-321401-w4ne60fn	279	1	This	this	DT
cord-321401-w4ne60fn	279	2	information	information	NN
cord-321401-w4ne60fn	279	3	could	could	MD
cord-321401-w4ne60fn	279	4	lead	lead	VB
cord-321401-w4ne60fn	279	5	to	to	IN
cord-321401-w4ne60fn	279	6	improved	improve	VBN
cord-321401-w4ne60fn	279	7	treatment	treatment	NN
cord-321401-w4ne60fn	279	8	strategies	strategy	NNS
cord-321401-w4ne60fn	279	9	that	that	WDT
cord-321401-w4ne60fn	279	10	enhance	enhance	VBP
cord-321401-w4ne60fn	279	11	local	local	JJ
cord-321401-w4ne60fn	279	12	efficacy	efficacy	NN
cord-321401-w4ne60fn	279	13	of	of	IN
cord-321401-w4ne60fn	279	14	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	279	15	)	)	-RRB-
cord-321401-w4ne60fn	279	16	2	2	CD
cord-321401-w4ne60fn	279	17	D	d	NN
cord-321401-w4ne60fn	279	18	,	,	,
cord-321401-w4ne60fn	279	19	using	use	VBG
cord-321401-w4ne60fn	279	20	e.g.	e.g.	RB
cord-321401-w4ne60fn	279	21	,	,	,
cord-321401-w4ne60fn	279	22	specific	specific	JJ
cord-321401-w4ne60fn	279	23	CYP24A1-inhibitors	cyp24a1-inhibitor	NNS
cord-321401-w4ne60fn	279	24	such	such	JJ
cord-321401-w4ne60fn	279	25	as	as	IN
cord-321401-w4ne60fn	279	26	VID400	VID400	NNP
cord-321401-w4ne60fn	279	27	(	(	-LRB-
cord-321401-w4ne60fn	279	28	182	182	CD
cord-321401-w4ne60fn	279	29	)	)	-RRB-
cord-321401-w4ne60fn	279	30	.	.	.
cord-321401-w4ne60fn	280	1	Alternatively	alternatively	RB
cord-321401-w4ne60fn	280	2	,	,	,
cord-321401-w4ne60fn	280	3	degradation	degradation	NN
cord-321401-w4ne60fn	280	4	by	by	IN
cord-321401-w4ne60fn	280	5	CYP24A1	CYP24A1	NNP
cord-321401-w4ne60fn	280	6	could	could	MD
cord-321401-w4ne60fn	280	7	be	be	VB
cord-321401-w4ne60fn	280	8	prevented	prevent	VBN
cord-321401-w4ne60fn	280	9	by	by	IN
cord-321401-w4ne60fn	280	10	using	use	VBG
cord-321401-w4ne60fn	280	11	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	280	12	)	)	-RRB-
cord-321401-w4ne60fn	280	13	2	2	CD
cord-321401-w4ne60fn	280	14	D	d	NN
cord-321401-w4ne60fn	280	15	analogs	analog	NNS
cord-321401-w4ne60fn	280	16	that	that	WDT
cord-321401-w4ne60fn	280	17	are	be	VBP
cord-321401-w4ne60fn	280	18	insensitive	insensitive	JJ
cord-321401-w4ne60fn	280	19	to	to	IN
cord-321401-w4ne60fn	280	20	CYP24A1-mediated	cyp24a1-mediated	JJ
cord-321401-w4ne60fn	280	21	degradation	degradation	NN
cord-321401-w4ne60fn	280	22	,	,	,
cord-321401-w4ne60fn	280	23	such	such	JJ
cord-321401-w4ne60fn	280	24	as	as	IN
cord-321401-w4ne60fn	280	25	sulfone	sulfone	NNP
cord-321401-w4ne60fn	280	26	and	and	CC
cord-321401-w4ne60fn	280	27	sulfoximine	sulfoximine	JJ
cord-321401-w4ne60fn	280	28	derivatives	derivative	NNS
cord-321401-w4ne60fn	280	29	,	,	,
cord-321401-w4ne60fn	280	30	that	that	WDT
cord-321401-w4ne60fn	280	31	also	also	RB
cord-321401-w4ne60fn	280	32	act	act	VBP
cord-321401-w4ne60fn	280	33	as	as	IN
cord-321401-w4ne60fn	280	34	a	a	DT
cord-321401-w4ne60fn	280	35	VDR	VDR	NNP
cord-321401-w4ne60fn	280	36	agonist	agonist	NN
cord-321401-w4ne60fn	280	37	(	(	-LRB-
cord-321401-w4ne60fn	280	38	183	183	CD
cord-321401-w4ne60fn	280	39	)	)	-RRB-
cord-321401-w4ne60fn	280	40	.	.	.
cord-321401-w4ne60fn	281	1	A	a	DT
cord-321401-w4ne60fn	281	2	third	third	JJ
cord-321401-w4ne60fn	281	3	option	option	NN
cord-321401-w4ne60fn	281	4	is	be	VBZ
cord-321401-w4ne60fn	281	5	to	to	TO
cord-321401-w4ne60fn	281	6	entail	entail	VB
cord-321401-w4ne60fn	281	7	the	the	DT
cord-321401-w4ne60fn	281	8	use	use	NN
cord-321401-w4ne60fn	281	9	of	of	IN
cord-321401-w4ne60fn	281	10	combination	combination	NN
cord-321401-w4ne60fn	281	11	treatment	treatment	NN
cord-321401-w4ne60fn	281	12	with	with	IN
cord-321401-w4ne60fn	281	13	vitamin	vitamin	NN
cord-321401-w4ne60fn	281	14	D	d	NN
cord-321401-w4ne60fn	281	15	and	and	CC
cord-321401-w4ne60fn	281	16	anti	anti	JJ
cord-321401-w4ne60fn	281	17	-	-	JJ
cord-321401-w4ne60fn	281	18	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	281	19	or	or	CC
cord-321401-w4ne60fn	281	20	certain	certain	JJ
cord-321401-w4ne60fn	281	21	anti	anti	JJ
cord-321401-w4ne60fn	281	22	-	-	JJ
cord-321401-w4ne60fn	281	23	fibrotic	fibrotic	JJ
cord-321401-w4ne60fn	281	24	drugs	drug	NNS
cord-321401-w4ne60fn	281	25	that	that	WDT
cord-321401-w4ne60fn	281	26	target	target	VBP
cord-321401-w4ne60fn	281	27	cytokines	cytokine	NNS
cord-321401-w4ne60fn	281	28	/	/	SYM
cord-321401-w4ne60fn	281	29	proteins	protein	NNS
cord-321401-w4ne60fn	281	30	that	that	WDT
cord-321401-w4ne60fn	281	31	are	be	VBP
cord-321401-w4ne60fn	281	32	known	know	VBN
cord-321401-w4ne60fn	281	33	to	to	TO
cord-321401-w4ne60fn	281	34	potentially	potentially	RB
cord-321401-w4ne60fn	281	35	decrease	decrease	VB
cord-321401-w4ne60fn	281	36	local	local	JJ
cord-321401-w4ne60fn	281	37	levels	level	NNS
cord-321401-w4ne60fn	281	38	and	and	CC
cord-321401-w4ne60fn	281	39	signaling	signaling	NN
cord-321401-w4ne60fn	281	40	of	of	IN
cord-321401-w4ne60fn	281	41	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	281	42	)	)	-RRB-
cord-321401-w4ne60fn	281	43	2	2	CD
cord-321401-w4ne60fn	281	44	D	d	NN
cord-321401-w4ne60fn	281	45	by	by	IN
cord-321401-w4ne60fn	281	46	inducing	induce	VBG
cord-321401-w4ne60fn	281	47	expression	expression	NN
cord-321401-w4ne60fn	281	48	of	of	IN
cord-321401-w4ne60fn	281	49	CYP24A1	CYP24A1	NNP
cord-321401-w4ne60fn	281	50	(	(	-LRB-
cord-321401-w4ne60fn	281	51	48	48	CD
cord-321401-w4ne60fn	281	52	,	,	,
cord-321401-w4ne60fn	281	53	184	184	CD
cord-321401-w4ne60fn	281	54	,	,	,
cord-321401-w4ne60fn	281	55	185	185	CD
cord-321401-w4ne60fn	281	56	)	)	-RRB-
cord-321401-w4ne60fn	281	57	.	.	.
cord-321401-w4ne60fn	282	1	When	when	WRB
cord-321401-w4ne60fn	282	2	considering	consider	VBG
cord-321401-w4ne60fn	282	3	such	such	JJ
cord-321401-w4ne60fn	282	4	strategies	strategy	NNS
cord-321401-w4ne60fn	282	5	,	,	,
cord-321401-w4ne60fn	282	6	it	-PRON-	PRP
cord-321401-w4ne60fn	282	7	should	should	MD
cord-321401-w4ne60fn	282	8	be	be	VB
cord-321401-w4ne60fn	282	9	noted	note	VBN
cord-321401-w4ne60fn	282	10	that	that	IN
cord-321401-w4ne60fn	282	11	these	these	DT
cord-321401-w4ne60fn	282	12	may	may	MD
cord-321401-w4ne60fn	282	13	enhance	enhance	VB
cord-321401-w4ne60fn	282	14	the	the	DT
cord-321401-w4ne60fn	282	15	calcemic	calcemic	JJ
cord-321401-w4ne60fn	282	16	side	side	NN
cord-321401-w4ne60fn	282	17	effects	effect	NNS
cord-321401-w4ne60fn	282	18	and	and	CC
cord-321401-w4ne60fn	282	19	lead	lead	VBP
cord-321401-w4ne60fn	282	20	to	to	IN
cord-321401-w4ne60fn	282	21	unwanted	unwanted	JJ
cord-321401-w4ne60fn	282	22	inhibition	inhibition	NN
cord-321401-w4ne60fn	282	23	of	of	IN
cord-321401-w4ne60fn	282	24	the	the	DT
cord-321401-w4ne60fn	282	25	immune	immune	JJ
cord-321401-w4ne60fn	282	26	system	system	NN
cord-321401-w4ne60fn	282	27	.	.	.
cord-321401-w4ne60fn	283	1	We	-PRON-	PRP
cord-321401-w4ne60fn	283	2	therefore	therefore	RB
cord-321401-w4ne60fn	283	3	need	need	VBP
cord-321401-w4ne60fn	283	4	to	to	TO
cord-321401-w4ne60fn	283	5	carefully	carefully	RB
cord-321401-w4ne60fn	283	6	analyze	analyze	VB
cord-321401-w4ne60fn	283	7	the	the	DT
cord-321401-w4ne60fn	283	8	preclinical	preclinical	JJ
cord-321401-w4ne60fn	283	9	in	in	IN
cord-321401-w4ne60fn	283	10	vivo	vivo	NN
cord-321401-w4ne60fn	283	11	and	and	CC
cord-321401-w4ne60fn	283	12	in	in	IN
cord-321401-w4ne60fn	283	13	vitro	vitro	FW
cord-321401-w4ne60fn	283	14	studies	study	NNS
cord-321401-w4ne60fn	283	15	and	and	CC
cord-321401-w4ne60fn	283	16	balance	balance	VB
cord-321401-w4ne60fn	283	17	the	the	DT
cord-321401-w4ne60fn	283	18	pros	pro	NNS
cord-321401-w4ne60fn	283	19	and	and	CC
cord-321401-w4ne60fn	283	20	cons	con	NNS
cord-321401-w4ne60fn	283	21	of	of	IN
cord-321401-w4ne60fn	283	22	the	the	DT
cord-321401-w4ne60fn	283	23	different	different	JJ
cord-321401-w4ne60fn	283	24	strategies	strategy	NNS
cord-321401-w4ne60fn	283	25	.	.	.
cord-321401-w4ne60fn	284	1	In	in	IN
cord-321401-w4ne60fn	284	2	conclusion	conclusion	NN
cord-321401-w4ne60fn	284	3	,	,	,
cord-321401-w4ne60fn	284	4	future	future	JJ
cord-321401-w4ne60fn	284	5	studies	study	NNS
cord-321401-w4ne60fn	284	6	in	in	IN
cord-321401-w4ne60fn	284	7	COPD	COPD	NNP
cord-321401-w4ne60fn	284	8	and	and	CC
cord-321401-w4ne60fn	284	9	but	but	CC
cord-321401-w4ne60fn	284	10	also	also	RB
cord-321401-w4ne60fn	284	11	in	in	IN
cord-321401-w4ne60fn	284	12	other	other	JJ
cord-321401-w4ne60fn	284	13	chronic	chronic	JJ
cord-321401-w4ne60fn	284	14	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	284	15	diseases	disease	NNS
cord-321401-w4ne60fn	284	16	that	that	WDT
cord-321401-w4ne60fn	284	17	are	be	VBP
cord-321401-w4ne60fn	284	18	related	relate	VBN
cord-321401-w4ne60fn	284	19	to	to	IN
cord-321401-w4ne60fn	284	20	vitamin	vitamin	NN
cord-321401-w4ne60fn	284	21	D	D	NNP
cord-321401-w4ne60fn	284	22	deficiency	deficiency	NN
cord-321401-w4ne60fn	284	23	,	,	,
cord-321401-w4ne60fn	284	24	should	should	MD
cord-321401-w4ne60fn	284	25	be	be	VB
cord-321401-w4ne60fn	284	26	designed	design	VBN
cord-321401-w4ne60fn	284	27	with	with	IN
cord-321401-w4ne60fn	284	28	more	more	JJR
cord-321401-w4ne60fn	284	29	focus	focus	NN
cord-321401-w4ne60fn	284	30	on	on	IN
cord-321401-w4ne60fn	284	31	assessing	assess	VBG
cord-321401-w4ne60fn	284	32	and	and	CC
cord-321401-w4ne60fn	284	33	improving	improve	VBG
cord-321401-w4ne60fn	284	34	local	local	JJ
cord-321401-w4ne60fn	284	35	levels	level	NNS
cord-321401-w4ne60fn	284	36	of	of	IN
cord-321401-w4ne60fn	284	37	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	284	38	)	)	-RRB-
cord-321401-w4ne60fn	284	39	2	2	CD
cord-321401-w4ne60fn	284	40	D.	D.	NNP
cord-321401-w4ne60fn	285	1	These	these	DT
cord-321401-w4ne60fn	285	2	new	new	JJ
cord-321401-w4ne60fn	285	3	insights	insight	NNS
cord-321401-w4ne60fn	285	4	may	may	MD
cord-321401-w4ne60fn	285	5	lead	lead	VB
cord-321401-w4ne60fn	285	6	to	to	IN
cord-321401-w4ne60fn	285	7	the	the	DT
cord-321401-w4ne60fn	285	8	development	development	NN
cord-321401-w4ne60fn	285	9	of	of	IN
cord-321401-w4ne60fn	285	10	new	new	JJ
cord-321401-w4ne60fn	285	11	treatment	treatment	NN
cord-321401-w4ne60fn	285	12	strategies	strategy	NNS
cord-321401-w4ne60fn	285	13	,	,	,
cord-321401-w4ne60fn	285	14	such	such	JJ
cord-321401-w4ne60fn	285	15	as	as	IN
cord-321401-w4ne60fn	285	16	those	those	DT
cord-321401-w4ne60fn	285	17	targeting	target	VBG
cord-321401-w4ne60fn	285	18	CYP24A1	CYP24A1	NNP
cord-321401-w4ne60fn	285	19	to	to	TO
cord-321401-w4ne60fn	285	20	enhance	enhance	VB
cord-321401-w4ne60fn	285	21	local	local	JJ
cord-321401-w4ne60fn	285	22	1,25(OH	1,25(oh	CD
cord-321401-w4ne60fn	285	23	)	)	-RRB-
cord-321401-w4ne60fn	285	24	2	2	CD
cord-321401-w4ne60fn	285	25	D	d	NN
cord-321401-w4ne60fn	285	26	resulting	result	VBG
cord-321401-w4ne60fn	285	27	in	in	IN
cord-321401-w4ne60fn	285	28	improved	improved	JJ
cord-321401-w4ne60fn	285	29	homeostasis	homeostasis	NN
cord-321401-w4ne60fn	285	30	and	and	CC
cord-321401-w4ne60fn	285	31	protection	protection	NN
cord-321401-w4ne60fn	285	32	of	of	IN
cord-321401-w4ne60fn	285	33	the	the	DT
cord-321401-w4ne60fn	285	34	airway	airway	NN
cord-321401-w4ne60fn	285	35	mucosa	mucosa	NN
cord-321401-w4ne60fn	285	36	in	in	IN
cord-321401-w4ne60fn	285	37	patients	patient	NNS
cord-321401-w4ne60fn	285	38	with	with	IN
cord-321401-w4ne60fn	285	39	chronic	chronic	JJ
cord-321401-w4ne60fn	285	40	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	285	41	lung	lung	NN
cord-321401-w4ne60fn	285	42	diseases	disease	NNS
cord-321401-w4ne60fn	285	43	.	.	.
cord-321401-w4ne60fn	286	1	JS	JS	NNP
cord-321401-w4ne60fn	286	2	,	,	,
cord-321401-w4ne60fn	286	3	AD	ad	NN
cord-321401-w4ne60fn	286	4	,	,	,
cord-321401-w4ne60fn	286	5	and	and	CC
cord-321401-w4ne60fn	286	6	PH	ph	NN
cord-321401-w4ne60fn	286	7	:	:	:
cord-321401-w4ne60fn	286	8	Conception	conception	NN
cord-321401-w4ne60fn	286	9	and	and	CC
cord-321401-w4ne60fn	286	10	design	design	NN
cord-321401-w4ne60fn	286	11	.	.	.
cord-321401-w4ne60fn	287	1	JS	JS	NNP
cord-321401-w4ne60fn	287	2	:	:	:
cord-321401-w4ne60fn	288	1	Analyzing	analyze	VBG
cord-321401-w4ne60fn	288	2	literature	literature	NN
cord-321401-w4ne60fn	288	3	and	and	CC
cord-321401-w4ne60fn	288	4	drafting	draft	VBG
cord-321401-w4ne60fn	288	5	the	the	DT
cord-321401-w4ne60fn	288	6	manuscript	manuscript	NN
cord-321401-w4ne60fn	288	7	.	.	.
cord-321401-w4ne60fn	289	1	AD	ad	NN
cord-321401-w4ne60fn	289	2	and	and	CC
cord-321401-w4ne60fn	289	3	PH	ph	NN
cord-321401-w4ne60fn	289	4	:	:	:
cord-321401-w4ne60fn	289	5	Revision	revision	NN
cord-321401-w4ne60fn	289	6	of	of	IN
cord-321401-w4ne60fn	289	7	the	the	DT
cord-321401-w4ne60fn	289	8	manuscript	manuscript	NN
cord-321401-w4ne60fn	289	9	.	.	.
cord-321401-w4ne60fn	290	1	All	all	DT
cord-321401-w4ne60fn	290	2	authors	author	NNS
cord-321401-w4ne60fn	290	3	:	:	:
cord-321401-w4ne60fn	290	4	reviewed	review	VBD
cord-321401-w4ne60fn	290	5	the	the	DT
cord-321401-w4ne60fn	290	6	manuscript	manuscript	NN
cord-321401-w4ne60fn	290	7	and	and	CC
cord-321401-w4ne60fn	290	8	agree	agree	VB
cord-321401-w4ne60fn	290	9	with	with	IN
cord-321401-w4ne60fn	290	10	its	-PRON-	PRP$
cord-321401-w4ne60fn	290	11	submission	submission	NN
cord-321401-w4ne60fn	290	12	.	.	.
cord-321401-w4ne60fn	291	1	This	this	DT
cord-321401-w4ne60fn	291	2	study	study	NN
cord-321401-w4ne60fn	291	3	was	be	VBD
cord-321401-w4ne60fn	291	4	supported	support	VBN
cord-321401-w4ne60fn	291	5	by	by	IN
cord-321401-w4ne60fn	291	6	a	a	DT
cord-321401-w4ne60fn	291	7	grant	grant	NN
cord-321401-w4ne60fn	291	8	from	from	IN
cord-321401-w4ne60fn	291	9	the	the	DT
cord-321401-w4ne60fn	291	10	Lung	Lung	NNP
cord-321401-w4ne60fn	291	11	Foundation	Foundation	NNP
cord-321401-w4ne60fn	291	12	Netherlands	Netherlands	NNP
cord-321401-w4ne60fn	291	13	(	(	-LRB-
cord-321401-w4ne60fn	291	14	grant	grant	NN
cord-321401-w4ne60fn	291	15	#	#	NN
cord-321401-w4ne60fn	291	16	5.1.13.033	5.1.13.033	CD
cord-321401-w4ne60fn	291	17	)	)	-RRB-
cord-321401-w4ne60fn	291	18	and	and	CC
cord-321401-w4ne60fn	291	19	a	a	DT
cord-321401-w4ne60fn	291	20	Marie	Marie	NNP
cord-321401-w4ne60fn	291	21	Curie	Curie	NNP
cord-321401-w4ne60fn	291	22	Global	Global	NNP
cord-321401-w4ne60fn	291	23	Fellowship	Fellowship	NNP
cord-321401-w4ne60fn	291	24	(	(	-LRB-
cord-321401-w4ne60fn	291	25	grant	grant	NN
cord-321401-w4ne60fn	291	26	#	#	$
cord-321401-w4ne60fn	291	27	748569	748569	CD
cord-321401-w4ne60fn	291	28	-EpiCBiome	-epicbiome	CD
cord-321401-w4ne60fn	291	29	)	)	-RRB-
cord-321401-w4ne60fn	291	30	.	.	.
cord-321401-w4ne60fn	292	1	Vitamin	vitamin	NN
cord-321401-w4ne60fn	292	2	D	d	NN
cord-321401-w4ne60fn	292	3	and	and	CC
cord-321401-w4ne60fn	292	4	human	human	JJ
cord-321401-w4ne60fn	292	5	health	health	NN
cord-321401-w4ne60fn	292	6	:	:	:
cord-321401-w4ne60fn	292	7	lessons	lesson	NNS
cord-321401-w4ne60fn	292	8	from	from	IN
cord-321401-w4ne60fn	292	9	vitamin	vitamin	NN
cord-321401-w4ne60fn	292	10	D	d	NN
cord-321401-w4ne60fn	292	11	receptor	receptor	NN
cord-321401-w4ne60fn	293	1	null	null	JJ
cord-321401-w4ne60fn	293	2	mice	mouse	NNS
cord-321401-w4ne60fn	294	1	Large	large	JJ
cord-321401-w4ne60fn	294	2	-	-	HYPH
cord-321401-w4ne60fn	294	3	scale	scale	NN
cord-321401-w4ne60fn	294	4	in	in	IN
cord-321401-w4ne60fn	294	5	silico	silico	NN
cord-321401-w4ne60fn	294	6	and	and	CC
cord-321401-w4ne60fn	294	7	microarray	microarray	NN
cord-321401-w4ne60fn	294	8	-	-	HYPH
cord-321401-w4ne60fn	294	9	based	base	VBN
cord-321401-w4ne60fn	294	10	identification	identification	NN
cord-321401-w4ne60fn	294	11	of	of	IN
cord-321401-w4ne60fn	294	12	direct	direct	JJ
cord-321401-w4ne60fn	294	13	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	CD
cord-321401-w4ne60fn	294	14	D3	D3	NNP
cord-321401-w4ne60fn	294	15	target	target	NN
cord-321401-w4ne60fn	294	16	genes	gene	NNS
cord-321401-w4ne60fn	294	17	Vitamin	vitamin	NN
cord-321401-w4ne60fn	294	18	D	d	NN
cord-321401-w4ne60fn	294	19	:	:	:
cord-321401-w4ne60fn	294	20	metabolism	metabolism	NN
cord-321401-w4ne60fn	294	21	,	,	,
cord-321401-w4ne60fn	294	22	molecular	molecular	JJ
cord-321401-w4ne60fn	294	23	mechanism	mechanism	NN
cord-321401-w4ne60fn	294	24	of	of	IN
cord-321401-w4ne60fn	294	25	action	action	NN
cord-321401-w4ne60fn	294	26	,	,	,
cord-321401-w4ne60fn	294	27	pleiotropic	pleiotropic	JJ
cord-321401-w4ne60fn	294	28	effects	effect	NNS
cord-321401-w4ne60fn	295	1	The	the	DT
cord-321401-w4ne60fn	295	2	turnover	turnover	NN
cord-321401-w4ne60fn	295	3	and	and	CC
cord-321401-w4ne60fn	295	4	transport	transport	NN
cord-321401-w4ne60fn	295	5	of	of	IN
cord-321401-w4ne60fn	295	6	vitamin	vitamin	NN
cord-321401-w4ne60fn	295	7	D	d	NN
cord-321401-w4ne60fn	295	8	and	and	CC
cord-321401-w4ne60fn	295	9	of	of	IN
cord-321401-w4ne60fn	295	10	a	a	DT
cord-321401-w4ne60fn	295	11	polar	polar	JJ
cord-321401-w4ne60fn	295	12	metabolite	metabolite	NN
cord-321401-w4ne60fn	295	13	with	with	IN
cord-321401-w4ne60fn	295	14	the	the	DT
cord-321401-w4ne60fn	295	15	properties	property	NNS
cord-321401-w4ne60fn	295	16	of	of	IN
cord-321401-w4ne60fn	295	17	25-hydroxycholecalciferol	25-hydroxycholecalciferol	CD
cord-321401-w4ne60fn	295	18	in	in	IN
cord-321401-w4ne60fn	295	19	human	human	JJ
cord-321401-w4ne60fn	295	20	plasma	plasma	NN
cord-321401-w4ne60fn	295	21	Treatment	Treatment	NNP
cord-321401-w4ne60fn	295	22	,	,	,
cord-321401-w4ne60fn	295	23	and	and	CC
cord-321401-w4ne60fn	295	24	prevention	prevention	NN
cord-321401-w4ne60fn	295	25	of	of	IN
cord-321401-w4ne60fn	295	26	Vitamin	vitamin	NN
cord-321401-w4ne60fn	295	27	D	D	NNP
cord-321401-w4ne60fn	295	28	deficiency	deficiency	NN
cord-321401-w4ne60fn	295	29	:	:	:
cord-321401-w4ne60fn	295	30	an	an	DT
cord-321401-w4ne60fn	295	31	endocrine	endocrine	JJ
cord-321401-w4ne60fn	295	32	society	society	NN
cord-321401-w4ne60fn	295	33	clinical	clinical	JJ
cord-321401-w4ne60fn	295	34	practice	practice	NN
cord-321401-w4ne60fn	295	35	guideline	guideline	NN
cord-321401-w4ne60fn	296	1	The	the	DT
cord-321401-w4ne60fn	296	2	vitamin	vitamin	NN
cord-321401-w4ne60fn	296	3	D	d	NN
cord-321401-w4ne60fn	296	4	deficiency	deficiency	NN
cord-321401-w4ne60fn	296	5	pandemic	pandemic	NN
cord-321401-w4ne60fn	296	6	:	:	:
cord-321401-w4ne60fn	296	7	approaches	approach	NNS
cord-321401-w4ne60fn	296	8	for	for	IN
cord-321401-w4ne60fn	296	9	diagnosis	diagnosis	NN
cord-321401-w4ne60fn	296	10	,	,	,
cord-321401-w4ne60fn	296	11	treatment	treatment	NN
cord-321401-w4ne60fn	296	12	and	and	CC
cord-321401-w4ne60fn	296	13	prevention	prevention	NN
cord-321401-w4ne60fn	297	1	The	the	DT
cord-321401-w4ne60fn	297	2	role	role	NN
cord-321401-w4ne60fn	297	3	of	of	IN
cord-321401-w4ne60fn	297	4	vitamin	vitamin	NN
cord-321401-w4ne60fn	297	5	D	d	NN
cord-321401-w4ne60fn	297	6	in	in	IN
cord-321401-w4ne60fn	297	7	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	297	8	disease	disease	NN
cord-321401-w4ne60fn	297	9	:	:	:
cord-321401-w4ne60fn	297	10	COPD	COPD	NNP
cord-321401-w4ne60fn	297	11	,	,	,
cord-321401-w4ne60fn	297	12	asthma	asthma	NN
cord-321401-w4ne60fn	297	13	,	,	,
cord-321401-w4ne60fn	297	14	infection	infection	NN
cord-321401-w4ne60fn	297	15	,	,	,
cord-321401-w4ne60fn	297	16	and	and	CC
cord-321401-w4ne60fn	297	17	cancer	cancer	NN
cord-321401-w4ne60fn	298	1	The	the	DT
cord-321401-w4ne60fn	298	2	association	association	NN
cord-321401-w4ne60fn	298	3	between	between	IN
cord-321401-w4ne60fn	298	4	vitamin	vitamin	NN
cord-321401-w4ne60fn	298	5	D	D	NNP
cord-321401-w4ne60fn	298	6	and	and	CC
cord-321401-w4ne60fn	298	7	COPD	COPD	NNP
cord-321401-w4ne60fn	298	8	risk	risk	NN
cord-321401-w4ne60fn	298	9	,	,	,
cord-321401-w4ne60fn	298	10	severity	severity	NN
cord-321401-w4ne60fn	298	11	,	,	,
cord-321401-w4ne60fn	298	12	and	and	CC
cord-321401-w4ne60fn	298	13	exacerbation	exacerbation	NN
cord-321401-w4ne60fn	298	14	:	:	:
cord-321401-w4ne60fn	298	15	an	an	DT
cord-321401-w4ne60fn	298	16	updated	update	VBN
cord-321401-w4ne60fn	298	17	systematic	systematic	JJ
cord-321401-w4ne60fn	298	18	review	review	NN
cord-321401-w4ne60fn	298	19	and	and	CC
cord-321401-w4ne60fn	298	20	meta	meta	NNP
cord-321401-w4ne60fn	298	21	-	-	HYPH
cord-321401-w4ne60fn	298	22	analysis	analysis	NN
cord-321401-w4ne60fn	298	23	Vitamin	vitamin	NN
cord-321401-w4ne60fn	298	24	D	d	NN
cord-321401-w4ne60fn	298	25	and	and	CC
cord-321401-w4ne60fn	298	26	asthma	asthma	NN
cord-321401-w4ne60fn	298	27	-	-	HYPH
cord-321401-w4ne60fn	298	28	life	life	NN
cord-321401-w4ne60fn	298	29	after	after	IN
cord-321401-w4ne60fn	298	30	VIDA	VIDA	NNP
cord-321401-w4ne60fn	298	31	?	?	.
cord-321401-w4ne60fn	299	1	Vitamin	vitamin	NN
cord-321401-w4ne60fn	299	2	D	d	NN
cord-321401-w4ne60fn	299	3	deficiency	deficiency	NN
cord-321401-w4ne60fn	299	4	is	be	VBZ
cord-321401-w4ne60fn	299	5	highly	highly	RB
cord-321401-w4ne60fn	299	6	prevalent	prevalent	JJ
cord-321401-w4ne60fn	299	7	in	in	IN
cord-321401-w4ne60fn	299	8	COPD	COPD	NNP
cord-321401-w4ne60fn	299	9	and	and	CC
cord-321401-w4ne60fn	299	10	correlates	correlate	VBZ
cord-321401-w4ne60fn	299	11	with	with	IN
cord-321401-w4ne60fn	299	12	variants	variant	NNS
cord-321401-w4ne60fn	299	13	in	in	IN
cord-321401-w4ne60fn	299	14	the	the	DT
cord-321401-w4ne60fn	299	15	vitamin	vitamin	NN
cord-321401-w4ne60fn	299	16	D	d	NN
cord-321401-w4ne60fn	299	17	-	-	HYPH
cord-321401-w4ne60fn	299	18	binding	bind	VBG
cord-321401-w4ne60fn	299	19	gene	gene	NN
cord-321401-w4ne60fn	299	20	Chronic	Chronic	NNP
cord-321401-w4ne60fn	299	21	obstructive	obstructive	JJ
cord-321401-w4ne60fn	299	22	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	299	23	disease	disease	NN
cord-321401-w4ne60fn	299	24	is	be	VBZ
cord-321401-w4ne60fn	299	25	associated	associate	VBN
cord-321401-w4ne60fn	299	26	with	with	IN
cord-321401-w4ne60fn	299	27	low	low	JJ
cord-321401-w4ne60fn	299	28	levels	level	NNS
cord-321401-w4ne60fn	299	29	of	of	IN
cord-321401-w4ne60fn	299	30	vitamin	vitamin	NN
cord-321401-w4ne60fn	299	31	D	D	NNP
cord-321401-w4ne60fn	299	32	Associations	association	NNS
cord-321401-w4ne60fn	299	33	between	between	IN
cord-321401-w4ne60fn	299	34	25-hydroxy	25-hydroxy	CD
cord-321401-w4ne60fn	299	35	-	-	HYPH
cord-321401-w4ne60fn	299	36	vitamin	vitamin	NN
cord-321401-w4ne60fn	299	37	D	d	NN
cord-321401-w4ne60fn	299	38	levels	level	NNS
cord-321401-w4ne60fn	299	39	,	,	,
cord-321401-w4ne60fn	299	40	lung	lung	NN
cord-321401-w4ne60fn	299	41	function	function	NN
cord-321401-w4ne60fn	299	42	,	,	,
cord-321401-w4ne60fn	299	43	and	and	CC
cord-321401-w4ne60fn	299	44	exacerbation	exacerbation	NN
cord-321401-w4ne60fn	299	45	outcomes	outcome	NNS
cord-321401-w4ne60fn	299	46	in	in	IN
cord-321401-w4ne60fn	299	47	COPD	COPD	NNP
cord-321401-w4ne60fn	299	48	:	:	:
cord-321401-w4ne60fn	299	49	an	an	DT
cord-321401-w4ne60fn	299	50	analysis	analysis	NN
cord-321401-w4ne60fn	299	51	of	of	IN
cord-321401-w4ne60fn	299	52	the	the	DT
cord-321401-w4ne60fn	299	53	SPIROMICS	SPIROMICS	NNP
cord-321401-w4ne60fn	299	54	cohort	cohort	NN
cord-321401-w4ne60fn	299	55	Vitamin	vitamin	NN
cord-321401-w4ne60fn	299	56	D	D	NNP
cord-321401-w4ne60fn	299	57	deficiency	deficiency	NN
cord-321401-w4ne60fn	299	58	:	:	:
cord-321401-w4ne60fn	299	59	what	what	WP
cord-321401-w4ne60fn	299	60	does	do	VBZ
cord-321401-w4ne60fn	299	61	it	-PRON-	PRP
cord-321401-w4ne60fn	299	62	mean	mean	VB
cord-321401-w4ne60fn	299	63	for	for	IN
cord-321401-w4ne60fn	299	64	chronic	chronic	JJ
cord-321401-w4ne60fn	299	65	obstructive	obstructive	JJ
cord-321401-w4ne60fn	299	66	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	299	67	disease	disease	NN
cord-321401-w4ne60fn	299	68	(	(	-LRB-
cord-321401-w4ne60fn	299	69	COPD	COPD	NNP
cord-321401-w4ne60fn	299	70	)	)	-RRB-
cord-321401-w4ne60fn	299	71	?	?	.
cord-321401-w4ne60fn	300	1	A	a	DT
cord-321401-w4ne60fn	300	2	compherensive	compherensive	JJ
cord-321401-w4ne60fn	300	3	review	review	NN
cord-321401-w4ne60fn	300	4	for	for	IN
cord-321401-w4ne60fn	300	5	pulmonologists	pulmonologists	NNP
cord-321401-w4ne60fn	300	6	Vitamin	Vitamin	NNP
cord-321401-w4ne60fn	300	7	D	D	NNP
cord-321401-w4ne60fn	300	8	,	,	,
cord-321401-w4ne60fn	300	9	vitamin	vitamin	NN
cord-321401-w4ne60fn	300	10	D	d	NN
cord-321401-w4ne60fn	300	11	binding	bind	VBG
cord-321401-w4ne60fn	300	12	protein	protein	NN
cord-321401-w4ne60fn	300	13	,	,	,
cord-321401-w4ne60fn	300	14	and	and	CC
cord-321401-w4ne60fn	300	15	longitudinal	longitudinal	JJ
cord-321401-w4ne60fn	300	16	outcomes	outcome	NNS
cord-321401-w4ne60fn	300	17	in	in	IN
cord-321401-w4ne60fn	300	18	COPD	COPD	NNP
cord-321401-w4ne60fn	301	1	Vitamin	vitamin	NN
cord-321401-w4ne60fn	301	2	D	d	NN
cord-321401-w4ne60fn	301	3	deficiency	deficiency	NN
cord-321401-w4ne60fn	301	4	causes	cause	VBZ
cord-321401-w4ne60fn	301	5	deficits	deficit	NNS
cord-321401-w4ne60fn	301	6	in	in	IN
cord-321401-w4ne60fn	301	7	lung	lung	NN
cord-321401-w4ne60fn	301	8	function	function	NN
cord-321401-w4ne60fn	301	9	and	and	CC
cord-321401-w4ne60fn	301	10	alters	alter	VBZ
cord-321401-w4ne60fn	301	11	lung	lung	NN
cord-321401-w4ne60fn	301	12	structure	structure	NN
cord-321401-w4ne60fn	301	13	Childhood	Childhood	NNP
cord-321401-w4ne60fn	301	14	lung	lung	NN
cord-321401-w4ne60fn	301	15	function	function	NN
cord-321401-w4ne60fn	301	16	predicts	predict	VBZ
cord-321401-w4ne60fn	301	17	adult	adult	NN
cord-321401-w4ne60fn	301	18	chronic	chronic	JJ
cord-321401-w4ne60fn	301	19	obstructive	obstructive	JJ
cord-321401-w4ne60fn	301	20	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	301	21	disease	disease	NN
cord-321401-w4ne60fn	301	22	and	and	CC
cord-321401-w4ne60fn	301	23	asthma	asthma	NN
cord-321401-w4ne60fn	301	24	-	-	HYPH
cord-321401-w4ne60fn	301	25	chronic	chronic	JJ
cord-321401-w4ne60fn	301	26	obstructive	obstructive	JJ
cord-321401-w4ne60fn	301	27	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	301	28	disease	disease	NN
cord-321401-w4ne60fn	301	29	overlap	overlap	VB
cord-321401-w4ne60fn	301	30	syndrome	syndrome	NN
cord-321401-w4ne60fn	301	31	Prenatal	prenatal	JJ
cord-321401-w4ne60fn	301	32	vitamin	vitamin	NN
cord-321401-w4ne60fn	301	33	D	d	NN
cord-321401-w4ne60fn	301	34	supplementation	supplementation	NN
cord-321401-w4ne60fn	301	35	reduces	reduce	VBZ
cord-321401-w4ne60fn	301	36	risk	risk	NN
cord-321401-w4ne60fn	301	37	of	of	IN
cord-321401-w4ne60fn	301	38	asthma	asthma	NN
cord-321401-w4ne60fn	301	39	/	/	SYM
cord-321401-w4ne60fn	301	40	recurrent	recurrent	JJ
cord-321401-w4ne60fn	301	41	wheeze	wheeze	NN
cord-321401-w4ne60fn	301	42	in	in	IN
cord-321401-w4ne60fn	301	43	early	early	JJ
cord-321401-w4ne60fn	301	44	childhood	childhood	NN
cord-321401-w4ne60fn	301	45	:	:	:
cord-321401-w4ne60fn	301	46	a	a	DT
cord-321401-w4ne60fn	301	47	combined	combine	VBN
cord-321401-w4ne60fn	301	48	analysis	analysis	NN
cord-321401-w4ne60fn	301	49	of	of	IN
cord-321401-w4ne60fn	301	50	two	two	CD
cord-321401-w4ne60fn	301	51	randomized	randomized	JJ
cord-321401-w4ne60fn	301	52	controlled	control	VBN
cord-321401-w4ne60fn	301	53	trials	trial	NNS
cord-321401-w4ne60fn	301	54	Vitamin	vitamin	NN
cord-321401-w4ne60fn	301	55	D	d	NN
cord-321401-w4ne60fn	301	56	related	relate	VBN
cord-321401-w4ne60fn	301	57	genes	gene	NNS
cord-321401-w4ne60fn	301	58	in	in	IN
cord-321401-w4ne60fn	301	59	lung	lung	NN
cord-321401-w4ne60fn	301	60	development	development	NN
cord-321401-w4ne60fn	301	61	and	and	CC
cord-321401-w4ne60fn	301	62	asthma	asthma	NN
cord-321401-w4ne60fn	301	63	pathogenesis	pathogenesis	NN
cord-321401-w4ne60fn	302	1	The	the	DT
cord-321401-w4ne60fn	302	2	role	role	NN
cord-321401-w4ne60fn	302	3	of	of	IN
cord-321401-w4ne60fn	302	4	the	the	DT
cord-321401-w4ne60fn	302	5	17q21	17q21	CD
cord-321401-w4ne60fn	302	6	genotype	genotype	NN
cord-321401-w4ne60fn	302	7	in	in	IN
cord-321401-w4ne60fn	302	8	the	the	DT
cord-321401-w4ne60fn	302	9	prevention	prevention	NN
cord-321401-w4ne60fn	302	10	of	of	IN
cord-321401-w4ne60fn	302	11	early	early	JJ
cord-321401-w4ne60fn	302	12	childhood	childhood	NN
cord-321401-w4ne60fn	302	13	asthma	asthma	NN
cord-321401-w4ne60fn	302	14	and	and	CC
cord-321401-w4ne60fn	302	15	recurrent	recurrent	JJ
cord-321401-w4ne60fn	302	16	wheeze	wheeze	NN
cord-321401-w4ne60fn	302	17	by	by	IN
cord-321401-w4ne60fn	302	18	vitamin	vitamin	NN
cord-321401-w4ne60fn	302	19	D	D	NNP
cord-321401-w4ne60fn	302	20	Factors	factor	NNS
cord-321401-w4ne60fn	302	21	influencing	influence	VBG
cord-321401-w4ne60fn	302	22	the	the	DT
cord-321401-w4ne60fn	302	23	infant	infant	NN
cord-321401-w4ne60fn	302	24	gut	gut	NN
cord-321401-w4ne60fn	302	25	microbiome	microbiome	NN
cord-321401-w4ne60fn	302	26	at	at	IN
cord-321401-w4ne60fn	302	27	age	age	NN
cord-321401-w4ne60fn	302	28	3	3	CD
cord-321401-w4ne60fn	302	29	-	-	SYM
cord-321401-w4ne60fn	302	30	6	6	CD
cord-321401-w4ne60fn	302	31	months	month	NNS
cord-321401-w4ne60fn	302	32	:	:	:
cord-321401-w4ne60fn	302	33	findings	finding	NNS
cord-321401-w4ne60fn	302	34	from	from	IN
cord-321401-w4ne60fn	302	35	the	the	DT
cord-321401-w4ne60fn	302	36	ethnically	ethnically	RB
cord-321401-w4ne60fn	302	37	diverse	diverse	JJ
cord-321401-w4ne60fn	302	38	Vitamin	vitamin	NN
cord-321401-w4ne60fn	302	39	D	d	NN
cord-321401-w4ne60fn	302	40	Antenatal	Antenatal	NNP
cord-321401-w4ne60fn	302	41	Asthma	Asthma	NNP
cord-321401-w4ne60fn	302	42	Reduction	Reduction	NNP
cord-321401-w4ne60fn	302	43	Trial	Trial	NNP
cord-321401-w4ne60fn	302	44	(	(	-LRB-
cord-321401-w4ne60fn	302	45	VDAART	VDAART	NNP
cord-321401-w4ne60fn	302	46	)	)	-RRB-
cord-321401-w4ne60fn	303	1	Vitamin	vitamin	NN
cord-321401-w4ne60fn	303	2	D	d	NN
cord-321401-w4ne60fn	303	3	deficiency	deficiency	NN
cord-321401-w4ne60fn	303	4	exacerbates	exacerbate	VBZ
cord-321401-w4ne60fn	303	5	COPD	COPD	NNP
cord-321401-w4ne60fn	303	6	-	-	HYPH
cord-321401-w4ne60fn	303	7	like	like	JJ
cord-321401-w4ne60fn	303	8	characteristics	characteristic	NNS
cord-321401-w4ne60fn	303	9	in	in	IN
cord-321401-w4ne60fn	303	10	the	the	DT
cord-321401-w4ne60fn	303	11	lungs	lung	NNS
cord-321401-w4ne60fn	303	12	of	of	IN
cord-321401-w4ne60fn	303	13	cigarette	cigarette	NN
cord-321401-w4ne60fn	303	14	smoke	smoke	NN
cord-321401-w4ne60fn	303	15	-	-	HYPH
cord-321401-w4ne60fn	303	16	exposed	expose	VBN
cord-321401-w4ne60fn	303	17	mice	mouse	NNS
cord-321401-w4ne60fn	303	18	Pulmonary	Pulmonary	NNP
cord-321401-w4ne60fn	303	19	administration	administration	NN
cord-321401-w4ne60fn	303	20	of	of	IN
cord-321401-w4ne60fn	303	21	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	CD
cord-321401-w4ne60fn	303	22	D3	D3	NNP
cord-321401-w4ne60fn	303	23	to	to	IN
cord-321401-w4ne60fn	303	24	the	the	DT
cord-321401-w4ne60fn	303	25	lungs	lung	NNS
cord-321401-w4ne60fn	303	26	induces	induce	VBZ
cord-321401-w4ne60fn	303	27	alveolar	alveolar	JJ
cord-321401-w4ne60fn	303	28	regeneration	regeneration	NN
cord-321401-w4ne60fn	303	29	in	in	IN
cord-321401-w4ne60fn	303	30	a	a	DT
cord-321401-w4ne60fn	303	31	mouse	mouse	NN
cord-321401-w4ne60fn	303	32	model	model	NN
cord-321401-w4ne60fn	303	33	of	of	IN
cord-321401-w4ne60fn	303	34	chronic	chronic	JJ
cord-321401-w4ne60fn	303	35	obstructive	obstructive	JJ
cord-321401-w4ne60fn	303	36	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	303	37	disease	disease	NN
cord-321401-w4ne60fn	303	38	Role	role	NN
cord-321401-w4ne60fn	303	39	of	of	IN
cord-321401-w4ne60fn	303	40	Vitamin	vitamin	NN
cord-321401-w4ne60fn	303	41	D	d	NN
cord-321401-w4ne60fn	303	42	in	in	IN
cord-321401-w4ne60fn	303	43	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	303	44	bowel	bowel	NN
cord-321401-w4ne60fn	303	45	disease	disease	NN
cord-321401-w4ne60fn	304	1	Vitamin	vitamin	NN
cord-321401-w4ne60fn	304	2	D	d	NN
cord-321401-w4ne60fn	304	3	supplementation	supplementation	NN
cord-321401-w4ne60fn	304	4	to	to	TO
cord-321401-w4ne60fn	304	5	prevent	prevent	VB
cord-321401-w4ne60fn	304	6	asthma	asthma	NN
cord-321401-w4ne60fn	304	7	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	304	8	:	:	:
cord-321401-w4ne60fn	305	1	a	a	DT
cord-321401-w4ne60fn	305	2	systematic	systematic	JJ
cord-321401-w4ne60fn	305	3	review	review	NN
cord-321401-w4ne60fn	305	4	and	and	CC
cord-321401-w4ne60fn	305	5	meta	meta	NNP
cord-321401-w4ne60fn	305	6	-	-	HYPH
cord-321401-w4ne60fn	305	7	analysis	analysis	NN
cord-321401-w4ne60fn	305	8	of	of	IN
cord-321401-w4ne60fn	305	9	individual	individual	JJ
cord-321401-w4ne60fn	305	10	participant	participant	NN
cord-321401-w4ne60fn	305	11	data	datum	NNS
cord-321401-w4ne60fn	305	12	Airway	airway	NN
cord-321401-w4ne60fn	305	13	epithelium	epithelium	NN
cord-321401-w4ne60fn	305	14	dysfunction	dysfunction	NN
cord-321401-w4ne60fn	305	15	in	in	IN
cord-321401-w4ne60fn	305	16	cystic	cystic	JJ
cord-321401-w4ne60fn	305	17	fibrosis	fibrosis	NN
cord-321401-w4ne60fn	305	18	and	and	CC
cord-321401-w4ne60fn	305	19	COPD	COPD	NNP
cord-321401-w4ne60fn	305	20	Mend	mend	VB
cord-321401-w4ne60fn	305	21	your	-PRON-	PRP$
cord-321401-w4ne60fn	305	22	fences	fence	NNS
cord-321401-w4ne60fn	305	23	:	:	:
cord-321401-w4ne60fn	305	24	the	the	DT
cord-321401-w4ne60fn	305	25	epithelial	epithelial	JJ
cord-321401-w4ne60fn	305	26	barrier	barrier	NN
cord-321401-w4ne60fn	305	27	and	and	CC
cord-321401-w4ne60fn	305	28	its	-PRON-	PRP$
cord-321401-w4ne60fn	305	29	relationship	relationship	NN
cord-321401-w4ne60fn	305	30	with	with	IN
cord-321401-w4ne60fn	305	31	mucosal	mucosal	JJ
cord-321401-w4ne60fn	305	32	immunity	immunity	NN
cord-321401-w4ne60fn	305	33	in	in	IN
cord-321401-w4ne60fn	305	34	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	305	35	bowel	bowel	NN
cord-321401-w4ne60fn	305	36	disease	disease	NN
cord-321401-w4ne60fn	305	37	Airway	airway	NN
cord-321401-w4ne60fn	305	38	epithelial	epithelial	JJ
cord-321401-w4ne60fn	305	39	barrier	barrier	NN
cord-321401-w4ne60fn	305	40	function	function	NN
cord-321401-w4ne60fn	305	41	regulates	regulate	VBZ
cord-321401-w4ne60fn	305	42	the	the	DT
cord-321401-w4ne60fn	305	43	pathogenesis	pathogenesis	NN
cord-321401-w4ne60fn	305	44	of	of	IN
cord-321401-w4ne60fn	305	45	allergic	allergic	JJ
cord-321401-w4ne60fn	305	46	asthma	asthma	NN
cord-321401-w4ne60fn	305	47	Modulation	modulation	NN
cord-321401-w4ne60fn	305	48	of	of	IN
cord-321401-w4ne60fn	305	49	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	305	50	and	and	CC
cord-321401-w4ne60fn	305	51	immune	immune	JJ
cord-321401-w4ne60fn	305	52	responses	response	NNS
cord-321401-w4ne60fn	305	53	by	by	IN
cord-321401-w4ne60fn	305	54	vitamin	vitamin	NN
cord-321401-w4ne60fn	305	55	D	D	NNP
cord-321401-w4ne60fn	305	56	Innate	Innate	NNP
cord-321401-w4ne60fn	305	57	immune	immune	JJ
cord-321401-w4ne60fn	305	58	modulation	modulation	NN
cord-321401-w4ne60fn	305	59	in	in	IN
cord-321401-w4ne60fn	305	60	chronic	chronic	JJ
cord-321401-w4ne60fn	305	61	obstructive	obstructive	JJ
cord-321401-w4ne60fn	305	62	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	305	63	disease	disease	NN
cord-321401-w4ne60fn	305	64	:	:	:
cord-321401-w4ne60fn	305	65	moving	move	VBG
cord-321401-w4ne60fn	305	66	closer	close	RBR
cord-321401-w4ne60fn	305	67	toward	toward	IN
cord-321401-w4ne60fn	305	68	vitamin	vitamin	NN
cord-321401-w4ne60fn	305	69	D	d	NN
cord-321401-w4ne60fn	305	70	therapy	therapy	NN
cord-321401-w4ne60fn	305	71	Intestinal	intestinal	JJ
cord-321401-w4ne60fn	305	72	absorption	absorption	NN
cord-321401-w4ne60fn	305	73	of	of	IN
cord-321401-w4ne60fn	305	74	vitamin	vitamin	NN
cord-321401-w4ne60fn	305	75	D	d	NN
cord-321401-w4ne60fn	305	76	:	:	:
cord-321401-w4ne60fn	305	77	from	from	IN
cord-321401-w4ne60fn	305	78	the	the	DT
cord-321401-w4ne60fn	305	79	meal	meal	NN
cord-321401-w4ne60fn	305	80	to	to	IN
cord-321401-w4ne60fn	305	81	the	the	DT
cord-321401-w4ne60fn	305	82	enterocyte	enterocyte	NNP
cord-321401-w4ne60fn	306	1	The	the	DT
cord-321401-w4ne60fn	306	2	cutaneous	cutaneous	JJ
cord-321401-w4ne60fn	306	3	photosynthesis	photosynthesis	NN
cord-321401-w4ne60fn	306	4	of	of	IN
cord-321401-w4ne60fn	306	5	previtamin	previtamin	NNP
cord-321401-w4ne60fn	306	6	D3	D3	NNP
cord-321401-w4ne60fn	306	7	:	:	:
cord-321401-w4ne60fn	306	8	a	a	DT
cord-321401-w4ne60fn	306	9	unique	unique	JJ
cord-321401-w4ne60fn	306	10	photoendocrine	photoendocrine	NN
cord-321401-w4ne60fn	306	11	system	system	NN
cord-321401-w4ne60fn	306	12	Induction	Induction	NNP
cord-321401-w4ne60fn	306	13	of	of	IN
cord-321401-w4ne60fn	306	14	CFTR	CFTR	NNP
cord-321401-w4ne60fn	306	15	gene	gene	NN
cord-321401-w4ne60fn	306	16	expression	expression	NN
cord-321401-w4ne60fn	306	17	by	by	IN
cord-321401-w4ne60fn	306	18	1,25(OH)2	1,25(oh)2	JJ
cord-321401-w4ne60fn	306	19	vitamin	vitamin	NN
cord-321401-w4ne60fn	306	20	D3	D3	NNP
cord-321401-w4ne60fn	306	21	,	,	,
cord-321401-w4ne60fn	306	22	25OH	25oh	CD
cord-321401-w4ne60fn	306	23	vitamin	vitamin	NN
cord-321401-w4ne60fn	306	24	D3	D3	NNP
cord-321401-w4ne60fn	306	25	,	,	,
cord-321401-w4ne60fn	306	26	and	and	CC
cord-321401-w4ne60fn	306	27	vitamin	vitamin	NN
cord-321401-w4ne60fn	306	28	D3	D3	NNP
cord-321401-w4ne60fn	306	29	in	in	IN
cord-321401-w4ne60fn	306	30	cultured	cultured	JJ
cord-321401-w4ne60fn	306	31	human	human	JJ
cord-321401-w4ne60fn	306	32	airway	airway	NN
cord-321401-w4ne60fn	306	33	epithelial	epithelial	JJ
cord-321401-w4ne60fn	306	34	cells	cell	NNS
cord-321401-w4ne60fn	306	35	and	and	CC
cord-321401-w4ne60fn	306	36	in	in	IN
cord-321401-w4ne60fn	306	37	mouse	mouse	NN
cord-321401-w4ne60fn	306	38	airways	airways	NNP
cord-321401-w4ne60fn	306	39	UVB	UVB	NNP
cord-321401-w4ne60fn	306	40	-	-	HYPH
cord-321401-w4ne60fn	306	41	induced	induce	VBN
cord-321401-w4ne60fn	306	42	1,25(OH)2D3	1,25(oh)2d3	CD
cord-321401-w4ne60fn	306	43	production	production	NN
cord-321401-w4ne60fn	306	44	and	and	CC
cord-321401-w4ne60fn	306	45	vitamin	vitamin	NN
cord-321401-w4ne60fn	306	46	D	d	NN
cord-321401-w4ne60fn	306	47	activity	activity	NN
cord-321401-w4ne60fn	306	48	in	in	IN
cord-321401-w4ne60fn	306	49	intestinal	intestinal	JJ
cord-321401-w4ne60fn	306	50	CaCo-2	CaCo-2	NNP
cord-321401-w4ne60fn	306	51	cells	cell	NNS
cord-321401-w4ne60fn	306	52	and	and	CC
cord-321401-w4ne60fn	306	53	in	in	IN
cord-321401-w4ne60fn	306	54	THP-1	THP-1	NNP
cord-321401-w4ne60fn	306	55	macrophages	macrophage	NNS
cord-321401-w4ne60fn	306	56	pretreated	pretreate	VBN
cord-321401-w4ne60fn	306	57	with	with	IN
cord-321401-w4ne60fn	306	58	a	a	DT
cord-321401-w4ne60fn	306	59	sterol	sterol	NN
cord-321401-w4ne60fn	306	60	Delta7-reductase	Delta7-reductase	NNP
cord-321401-w4ne60fn	306	61	inhibitor	inhibitor	NN
cord-321401-w4ne60fn	306	62	Holick	Holick	NNP
cord-321401-w4ne60fn	306	63	Vitamin	vitamin	NN
cord-321401-w4ne60fn	306	64	-	-	HYPH
cord-321401-w4ne60fn	306	65	D	d	NN
cord-321401-w4ne60fn	306	66	synthesis	synthesis	NN
cord-321401-w4ne60fn	306	67	and	and	CC
cord-321401-w4ne60fn	306	68	metabolism	metabolism	NN
cord-321401-w4ne60fn	306	69	after	after	IN
cord-321401-w4ne60fn	306	70	ultraviolet	ultraviolet	NN
cord-321401-w4ne60fn	306	71	irradiation	irradiation	NN
cord-321401-w4ne60fn	306	72	of	of	IN
cord-321401-w4ne60fn	306	73	normal	normal	JJ
cord-321401-w4ne60fn	306	74	and	and	CC
cord-321401-w4ne60fn	306	75	vitamin	vitamin	NN
cord-321401-w4ne60fn	306	76	-	-	HYPH
cord-321401-w4ne60fn	306	77	D	d	NN
cord-321401-w4ne60fn	306	78	-	-	HYPH
cord-321401-w4ne60fn	306	79	deficient	deficient	JJ
cord-321401-w4ne60fn	306	80	subjects	subject	NNS
cord-321401-w4ne60fn	306	81	Immune	immune	VBP
cord-321401-w4ne60fn	306	82	regulation	regulation	NN
cord-321401-w4ne60fn	306	83	of	of	IN
cord-321401-w4ne60fn	306	84	25-hydroxyvitamin	25-hydroxyvitamin	CD
cord-321401-w4ne60fn	306	85	-	-	HYPH
cord-321401-w4ne60fn	306	86	D3	d3	NN
cord-321401-w4ne60fn	306	87	-	-	HYPH
cord-321401-w4ne60fn	306	88	1α	1α	CD
cord-321401-w4ne60fn	306	89	-	-	HYPH
cord-321401-w4ne60fn	306	90	hydroxylase	hydroxylase	NN
cord-321401-w4ne60fn	306	91	in	in	IN
cord-321401-w4ne60fn	306	92	human	human	JJ
cord-321401-w4ne60fn	306	93	monocytes	monocyte	NNS
cord-321401-w4ne60fn	306	94	Extrarenal	extrarenal	JJ
cord-321401-w4ne60fn	306	95	expression	expression	NN
cord-321401-w4ne60fn	306	96	of	of	IN
cord-321401-w4ne60fn	306	97	25-hydroxyvitamin	25-hydroxyvitamin	CD
cord-321401-w4ne60fn	306	98	D3	D3	NNP
cord-321401-w4ne60fn	306	99	-	-	HYPH
cord-321401-w4ne60fn	306	100	1α	1α	CD
cord-321401-w4ne60fn	306	101	-	-	HYPH
cord-321401-w4ne60fn	306	102	hydroxylase1	hydroxylase1	NN
cord-321401-w4ne60fn	306	103	Regulation	regulation	NN
cord-321401-w4ne60fn	306	104	of	of	IN
cord-321401-w4ne60fn	306	105	extrarenal	extrarenal	JJ
cord-321401-w4ne60fn	306	106	synthesis	synthesis	NN
cord-321401-w4ne60fn	306	107	of	of	IN
cord-321401-w4ne60fn	306	108	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	CD
cord-321401-w4ne60fn	306	109	D3	D3	NNP
cord-321401-w4ne60fn	306	110	-	-	HYPH
cord-321401-w4ne60fn	306	111	-relevance	-relevance	NN
cord-321401-w4ne60fn	307	1	for	for	IN
cord-321401-w4ne60fn	307	2	colonic	colonic	JJ
cord-321401-w4ne60fn	307	3	cancer	cancer	NN
cord-321401-w4ne60fn	307	4	prevention	prevention	NN
cord-321401-w4ne60fn	307	5	and	and	CC
cord-321401-w4ne60fn	307	6	therapy	therapy	NN
cord-321401-w4ne60fn	307	7	Respiratory	respiratory	JJ
cord-321401-w4ne60fn	307	8	epithelial	epithelial	JJ
cord-321401-w4ne60fn	307	9	cells	cell	NNS
cord-321401-w4ne60fn	307	10	convert	convert	VBP
cord-321401-w4ne60fn	307	11	inactive	inactive	JJ
cord-321401-w4ne60fn	307	12	vitamin	vitamin	NN
cord-321401-w4ne60fn	307	13	D	d	NN
cord-321401-w4ne60fn	307	14	to	to	IN
cord-321401-w4ne60fn	307	15	its	-PRON-	PRP$
cord-321401-w4ne60fn	307	16	active	active	JJ
cord-321401-w4ne60fn	307	17	form	form	NN
cord-321401-w4ne60fn	307	18	:	:	:
cord-321401-w4ne60fn	308	1	potential	potential	JJ
cord-321401-w4ne60fn	308	2	effects	effect	NNS
cord-321401-w4ne60fn	308	3	on	on	IN
cord-321401-w4ne60fn	308	4	host	host	NN
cord-321401-w4ne60fn	308	5	defense	defense	NN
cord-321401-w4ne60fn	308	6	T	t	NN
cord-321401-w4ne60fn	308	7	-	-	HYPH
cord-321401-w4ne60fn	308	8	cell	cell	NN
cord-321401-w4ne60fn	308	9	cytokines	cytokine	NNS
cord-321401-w4ne60fn	308	10	differentially	differentially	RB
cord-321401-w4ne60fn	308	11	control	control	VBP
cord-321401-w4ne60fn	308	12	human	human	JJ
cord-321401-w4ne60fn	308	13	monocyte	monocyte	NNP
cord-321401-w4ne60fn	308	14	antimicrobial	antimicrobial	JJ
cord-321401-w4ne60fn	308	15	responses	response	NNS
cord-321401-w4ne60fn	308	16	by	by	IN
cord-321401-w4ne60fn	308	17	regulating	regulate	VBG
cord-321401-w4ne60fn	308	18	vitamin	vitamin	NN
cord-321401-w4ne60fn	308	19	D	d	NN
cord-321401-w4ne60fn	308	20	metabolism	metabolism	NN
cord-321401-w4ne60fn	308	21	1	1	CD
cord-321401-w4ne60fn	308	22	,	,	,
cord-321401-w4ne60fn	309	1	25-dihydroxyvitamin	25-dihydroxyvitamin	CD
cord-321401-w4ne60fn	309	2	D	d	NN
cord-321401-w4ne60fn	309	3	production	production	NN
cord-321401-w4ne60fn	309	4	and	and	CC
cord-321401-w4ne60fn	309	5	receptor	receptor	NN
cord-321401-w4ne60fn	309	6	binding	bind	VBG
cord-321401-w4ne60fn	309	7	in	in	IN
cord-321401-w4ne60fn	309	8	human	human	JJ
cord-321401-w4ne60fn	309	9	keratinocytes	keratinocyte	NNS
cord-321401-w4ne60fn	309	10	varies	vary	VBZ
cord-321401-w4ne60fn	309	11	with	with	IN
cord-321401-w4ne60fn	309	12	differentiation	differentiation	NN
cord-321401-w4ne60fn	309	13	Where	where	WRB
cord-321401-w4ne60fn	309	14	is	be	VBZ
cord-321401-w4ne60fn	309	15	the	the	DT
cord-321401-w4ne60fn	309	16	vitamin	vitamin	NN
cord-321401-w4ne60fn	309	17	D	d	NN
cord-321401-w4ne60fn	309	18	receptor	receptor	NN
cord-321401-w4ne60fn	309	19	?	?	.
cord-321401-w4ne60fn	310	1	VDR	VDR	NNP
cord-321401-w4ne60fn	310	2	activation	activation	NN
cord-321401-w4ne60fn	310	3	of	of	IN
cord-321401-w4ne60fn	310	4	intracellular	intracellular	JJ
cord-321401-w4ne60fn	310	5	signaling	signal	VBG
cord-321401-w4ne60fn	310	6	pathways	pathway	NNS
cord-321401-w4ne60fn	310	7	in	in	IN
cord-321401-w4ne60fn	310	8	skeletal	skeletal	JJ
cord-321401-w4ne60fn	310	9	muscle	muscle	NN
cord-321401-w4ne60fn	310	10	Immunochemical	Immunochemical	NNP
cord-321401-w4ne60fn	310	11	identification	identification	NN
cord-321401-w4ne60fn	310	12	of	of	IN
cord-321401-w4ne60fn	310	13	the	the	DT
cord-321401-w4ne60fn	310	14	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	CD
cord-321401-w4ne60fn	310	15	D3	D3	NNP
cord-321401-w4ne60fn	310	16	receptor	receptor	NN
cord-321401-w4ne60fn	310	17	protein	protein	NN
cord-321401-w4ne60fn	310	18	in	in	IN
cord-321401-w4ne60fn	310	19	human	human	JJ
cord-321401-w4ne60fn	310	20	heart	heart	NN
cord-321401-w4ne60fn	310	21	Expression	Expression	NNP
cord-321401-w4ne60fn	310	22	of	of	IN
cord-321401-w4ne60fn	310	23	the	the	DT
cord-321401-w4ne60fn	310	24	Vitamin	vitamin	NN
cord-321401-w4ne60fn	310	25	D	d	NN
cord-321401-w4ne60fn	310	26	receptor	receptor	NN
cord-321401-w4ne60fn	310	27	is	be	VBZ
cord-321401-w4ne60fn	310	28	increased	increase	VBN
cord-321401-w4ne60fn	310	29	in	in	IN
cord-321401-w4ne60fn	310	30	the	the	DT
cord-321401-w4ne60fn	310	31	hypertrophic	hypertrophic	JJ
cord-321401-w4ne60fn	310	32	heart	heart	NN
cord-321401-w4ne60fn	311	1	The	the	DT
cord-321401-w4ne60fn	311	2	normal	normal	JJ
cord-321401-w4ne60fn	311	3	liver	liver	NN
cord-321401-w4ne60fn	311	4	harbors	harbor	VBZ
cord-321401-w4ne60fn	311	5	the	the	DT
cord-321401-w4ne60fn	311	6	vitamin	vitamin	NN
cord-321401-w4ne60fn	311	7	D	D	NNP
cord-321401-w4ne60fn	311	8	nuclear	nuclear	JJ
cord-321401-w4ne60fn	311	9	receptor	receptor	NN
cord-321401-w4ne60fn	311	10	in	in	IN
cord-321401-w4ne60fn	311	11	nonparenchymal	nonparenchymal	NNP
cord-321401-w4ne60fn	311	12	and	and	CC
cord-321401-w4ne60fn	311	13	biliary	biliary	JJ
cord-321401-w4ne60fn	311	14	epithelial	epithelial	JJ
cord-321401-w4ne60fn	311	15	cells	cell	NNS
cord-321401-w4ne60fn	311	16	Regulation	regulation	NN
cord-321401-w4ne60fn	311	17	of	of	IN
cord-321401-w4ne60fn	311	18	the	the	DT
cord-321401-w4ne60fn	311	19	vitamin	vitamin	NN
cord-321401-w4ne60fn	311	20	D	D	NNP
cord-321401-w4ne60fn	311	21	receptor	receptor	NN
cord-321401-w4ne60fn	311	22	gene	gene	NN
cord-321401-w4ne60fn	311	23	by	by	IN
cord-321401-w4ne60fn	311	24	environment	environment	NN
cord-321401-w4ne60fn	311	25	,	,	,
cord-321401-w4ne60fn	311	26	genetics	genetics	NN
cord-321401-w4ne60fn	311	27	and	and	CC
cord-321401-w4ne60fn	311	28	epigenetics	epigenetic	NNS
cord-321401-w4ne60fn	312	1	The	the	DT
cord-321401-w4ne60fn	312	2	impact	impact	NN
cord-321401-w4ne60fn	312	3	of	of	IN
cord-321401-w4ne60fn	312	4	VDR	VDR	NNP
cord-321401-w4ne60fn	312	5	expression	expression	NN
cord-321401-w4ne60fn	312	6	and	and	CC
cord-321401-w4ne60fn	312	7	regulation	regulation	NN
cord-321401-w4ne60fn	312	8	in	in	IN
cord-321401-w4ne60fn	312	9	vivo	vivo	NN
cord-321401-w4ne60fn	312	10	VDR	VDR	NNP
cord-321401-w4ne60fn	312	11	activity	activity	NN
cord-321401-w4ne60fn	312	12	is	be	VBZ
cord-321401-w4ne60fn	312	13	differentially	differentially	RB
cord-321401-w4ne60fn	312	14	affected	affect	VBN
cord-321401-w4ne60fn	312	15	by	by	IN
cord-321401-w4ne60fn	312	16	Hic-5	Hic-5	NNP
cord-321401-w4ne60fn	312	17	in	in	IN
cord-321401-w4ne60fn	312	18	prostate	prostate	NN
cord-321401-w4ne60fn	312	19	cancer	cancer	NN
cord-321401-w4ne60fn	312	20	and	and	CC
cord-321401-w4ne60fn	312	21	stromal	stromal	NN
cord-321401-w4ne60fn	312	22	cells	cell	NNS
cord-321401-w4ne60fn	312	23	Vitamin	vitamin	NN
cord-321401-w4ne60fn	312	24	D	d	NN
cord-321401-w4ne60fn	312	25	receptor	receptor	NN
cord-321401-w4ne60fn	312	26	as	as	IN
cord-321401-w4ne60fn	312	27	an	an	DT
cord-321401-w4ne60fn	312	28	intestinal	intestinal	JJ
cord-321401-w4ne60fn	312	29	bile	bile	NN
cord-321401-w4ne60fn	312	30	acid	acid	NN
cord-321401-w4ne60fn	312	31	sensor	sensor	NN
cord-321401-w4ne60fn	312	32	25-Hydroxyvitamin	25-hydroxyvitamin	CD
cord-321401-w4ne60fn	312	33	D-24-hydroxylase	d-24-hydroxylase	NN
cord-321401-w4ne60fn	313	1	(	(	-LRB-
cord-321401-w4ne60fn	313	2	CYP24A1	CYP24A1	NNP
cord-321401-w4ne60fn	313	3	)	)	-RRB-
cord-321401-w4ne60fn	313	4	:	:	:
cord-321401-w4ne60fn	314	1	Its	-PRON-	PRP$
cord-321401-w4ne60fn	314	2	important	important	JJ
cord-321401-w4ne60fn	314	3	role	role	NN
cord-321401-w4ne60fn	314	4	in	in	IN
cord-321401-w4ne60fn	314	5	the	the	DT
cord-321401-w4ne60fn	314	6	degradation	degradation	NN
cord-321401-w4ne60fn	314	7	of	of	IN
cord-321401-w4ne60fn	314	8	vitamin	vitamin	NN
cord-321401-w4ne60fn	314	9	D	d	NN
cord-321401-w4ne60fn	314	10	Interplay	interplay	NN
cord-321401-w4ne60fn	314	11	between	between	IN
cord-321401-w4ne60fn	314	12	vitamin	vitamin	NN
cord-321401-w4ne60fn	314	13	D	d	NN
cord-321401-w4ne60fn	314	14	and	and	CC
cord-321401-w4ne60fn	314	15	the	the	DT
cord-321401-w4ne60fn	314	16	drug	drug	NN
cord-321401-w4ne60fn	314	17	metabolizing	metabolize	VBG
cord-321401-w4ne60fn	314	18	enzyme	enzyme	NN
cord-321401-w4ne60fn	314	19	CYP3A4	CYP3A4	NNP
cord-321401-w4ne60fn	314	20	Dual	dual	JJ
cord-321401-w4ne60fn	314	21	metabolic	metabolic	JJ
cord-321401-w4ne60fn	314	22	pathway	pathway	NN
cord-321401-w4ne60fn	314	23	of	of	IN
cord-321401-w4ne60fn	314	24	25-hydroxyvitamin	25-hydroxyvitamin	CD
cord-321401-w4ne60fn	314	25	D3	D3	NNP
cord-321401-w4ne60fn	314	26	catalyzed	catalyze	VBN
cord-321401-w4ne60fn	314	27	by	by	IN
cord-321401-w4ne60fn	314	28	human	human	JJ
cord-321401-w4ne60fn	314	29	CYP24	cyp24	NN
cord-321401-w4ne60fn	315	1	Current	current	JJ
cord-321401-w4ne60fn	315	2	understanding	understanding	NN
cord-321401-w4ne60fn	315	3	of	of	IN
cord-321401-w4ne60fn	315	4	the	the	DT
cord-321401-w4ne60fn	315	5	molecular	molecular	JJ
cord-321401-w4ne60fn	315	6	actions	action	NNS
cord-321401-w4ne60fn	315	7	of	of	IN
cord-321401-w4ne60fn	315	8	vitamin	vitamin	NN
cord-321401-w4ne60fn	315	9	D	D	NNP
cord-321401-w4ne60fn	315	10	Chapter	Chapter	NNP
cord-321401-w4ne60fn	315	11	six	six	CD
cord-321401-w4ne60fn	315	12	-25-Hydroxyvitamin	-25-Hydroxyvitamin	NNP
cord-321401-w4ne60fn	315	13	D3	D3	NNP
cord-321401-w4ne60fn	315	14	24-Hydroxylase	24-hydroxylase	CD
cord-321401-w4ne60fn	315	15	:	:	:
cord-321401-w4ne60fn	315	16	a	a	DT
cord-321401-w4ne60fn	315	17	key	key	JJ
cord-321401-w4ne60fn	315	18	regulator	regulator	NN
cord-321401-w4ne60fn	315	19	of	of	IN
cord-321401-w4ne60fn	315	20	1,25(OH)2D3	1,25(oh)2d3	CD
cord-321401-w4ne60fn	315	21	catabolism	catabolism	NN
cord-321401-w4ne60fn	315	22	and	and	CC
cord-321401-w4ne60fn	315	23	calcium	calcium	NN
cord-321401-w4ne60fn	315	24	homeostasis	homeostasis	NN
cord-321401-w4ne60fn	315	25	Metabolic	metabolic	JJ
cord-321401-w4ne60fn	315	26	pathways	pathway	NNS
cord-321401-w4ne60fn	315	27	from	from	IN
cord-321401-w4ne60fn	315	28	1	1	CD
cord-321401-w4ne60fn	315	29	alpha,25-dihydroxyvitamin	alpha,25-dihydroxyvitamin	CD
cord-321401-w4ne60fn	315	30	D3	D3	NNP
cord-321401-w4ne60fn	315	31	to	to	IN
cord-321401-w4ne60fn	315	32	1	1	CD
cord-321401-w4ne60fn	315	33	alpha,25-dihydroxyvitamin	alpha,25-dihydroxyvitamin	CD
cord-321401-w4ne60fn	315	34	D3	D3	NNP
cord-321401-w4ne60fn	315	35	-	-	HYPH
cord-321401-w4ne60fn	315	36	26,23-lactone	26,23-lactone	NNP
cord-321401-w4ne60fn	315	37	.	.	.
cord-321401-w4ne60fn	316	1	Stereo	stereo	NN
cord-321401-w4ne60fn	316	2	-	-	HYPH
cord-321401-w4ne60fn	316	3	retained	retain	VBN
cord-321401-w4ne60fn	316	4	and	and	CC
cord-321401-w4ne60fn	316	5	stereo	stereo	NN
cord-321401-w4ne60fn	316	6	-	-	HYPH
cord-321401-w4ne60fn	316	7	selective	selective	JJ
cord-321401-w4ne60fn	316	8	lactonization	lactonization	NN
cord-321401-w4ne60fn	317	1	Calcitroic	Calcitroic	NNP
cord-321401-w4ne60fn	317	2	acid	acid	NN
cord-321401-w4ne60fn	317	3	is	be	VBZ
cord-321401-w4ne60fn	317	4	a	a	DT
cord-321401-w4ne60fn	317	5	major	major	JJ
cord-321401-w4ne60fn	317	6	catabolic	catabolic	JJ
cord-321401-w4ne60fn	317	7	metabolite	metabolite	NN
cord-321401-w4ne60fn	317	8	in	in	IN
cord-321401-w4ne60fn	317	9	the	the	DT
cord-321401-w4ne60fn	317	10	metabolism	metabolism	NN
cord-321401-w4ne60fn	317	11	of	of	IN
cord-321401-w4ne60fn	317	12	1α	1α	CD
cord-321401-w4ne60fn	317	13	-	-	HYPH
cord-321401-w4ne60fn	317	14	dihydroxyvitamin	dihydroxyvitamin	NN
cord-321401-w4ne60fn	317	15	D2	D2	NNP
cord-321401-w4ne60fn	317	16	Endocrine	Endocrine	NNP
cord-321401-w4ne60fn	317	17	functions	function	NNS
cord-321401-w4ne60fn	317	18	of	of	IN
cord-321401-w4ne60fn	317	19	bone	bone	NN
cord-321401-w4ne60fn	317	20	in	in	IN
cord-321401-w4ne60fn	317	21	mineral	mineral	NN
cord-321401-w4ne60fn	317	22	metabolism	metabolism	NN
cord-321401-w4ne60fn	317	23	regulation	regulation	NN
cord-321401-w4ne60fn	318	1	Vitamin	vitamin	NN
cord-321401-w4ne60fn	318	2	D	d	NN
cord-321401-w4ne60fn	318	3	increases	increase	VBZ
cord-321401-w4ne60fn	318	4	the	the	DT
cord-321401-w4ne60fn	318	5	antiviral	antiviral	JJ
cord-321401-w4ne60fn	318	6	activity	activity	NN
cord-321401-w4ne60fn	318	7	of	of	IN
cord-321401-w4ne60fn	318	8	bronchial	bronchial	JJ
cord-321401-w4ne60fn	318	9	epithelial	epithelial	JJ
cord-321401-w4ne60fn	318	10	cells	cell	NNS
cord-321401-w4ne60fn	318	11	in	in	IN
cord-321401-w4ne60fn	318	12	vitro	vitro	FW
cord-321401-w4ne60fn	318	13	Effects	effect	NNS
cord-321401-w4ne60fn	318	14	of	of	IN
cord-321401-w4ne60fn	318	15	vitamin	vitamin	NN
cord-321401-w4ne60fn	318	16	D	d	NN
cord-321401-w4ne60fn	318	17	on	on	IN
cord-321401-w4ne60fn	318	18	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	318	19	and	and	CC
cord-321401-w4ne60fn	318	20	oxidative	oxidative	JJ
cord-321401-w4ne60fn	318	21	stress	stress	NN
cord-321401-w4ne60fn	318	22	responses	response	NNS
cord-321401-w4ne60fn	318	23	of	of	IN
cord-321401-w4ne60fn	318	24	human	human	JJ
cord-321401-w4ne60fn	318	25	bronchial	bronchial	JJ
cord-321401-w4ne60fn	318	26	epithelial	epithelial	JJ
cord-321401-w4ne60fn	318	27	cells	cell	NNS
cord-321401-w4ne60fn	318	28	exposed	expose	VBN
cord-321401-w4ne60fn	318	29	to	to	IN
cord-321401-w4ne60fn	318	30	particulate	particulate	NN
cord-321401-w4ne60fn	318	31	matter	matter	NN
cord-321401-w4ne60fn	318	32	Allergen	allergen	NN
cord-321401-w4ne60fn	318	33	specific	specific	JJ
cord-321401-w4ne60fn	318	34	immunotherapy	immunotherapy	NN
cord-321401-w4ne60fn	318	35	enhanced	enhance	VBN
cord-321401-w4ne60fn	318	36	defense	defense	NN
cord-321401-w4ne60fn	318	37	against	against	IN
cord-321401-w4ne60fn	318	38	bacteria	bacteria	NNS
cord-321401-w4ne60fn	318	39	via	via	IN
cord-321401-w4ne60fn	318	40	TGF	TGF	NNP
cord-321401-w4ne60fn	318	41	-	-	HYPH
cord-321401-w4ne60fn	318	42	β1-induced	β1-induce	VBN
cord-321401-w4ne60fn	318	43	CYP27B1	cyp27b1	NN
cord-321401-w4ne60fn	318	44	in	in	IN
cord-321401-w4ne60fn	318	45	asthma	asthma	NN
cord-321401-w4ne60fn	319	1	Proinflammatory	proinflammatory	NN
cord-321401-w4ne60fn	319	2	cytokines	cytokine	NNS
cord-321401-w4ne60fn	319	3	impair	impair	VBP
cord-321401-w4ne60fn	319	4	vitamin	vitamin	NN
cord-321401-w4ne60fn	319	5	D	d	NN
cord-321401-w4ne60fn	319	6	-	-	HYPH
cord-321401-w4ne60fn	319	7	induced	induce	VBN
cord-321401-w4ne60fn	319	8	host	host	NN
cord-321401-w4ne60fn	319	9	defense	defense	NN
cord-321401-w4ne60fn	319	10	in	in	IN
cord-321401-w4ne60fn	319	11	cultured	cultured	JJ
cord-321401-w4ne60fn	319	12	airway	airway	NN
cord-321401-w4ne60fn	319	13	epithelial	epithelial	JJ
cord-321401-w4ne60fn	319	14	cells	cell	NNS
cord-321401-w4ne60fn	320	1	TGF	TGF	NNP
cord-321401-w4ne60fn	320	2	-	-	HYPH
cord-321401-w4ne60fn	320	3	beta1	beta1	NN
cord-321401-w4ne60fn	320	4	impairs	impair	VBZ
cord-321401-w4ne60fn	320	5	vitamin	vitamin	NN
cord-321401-w4ne60fn	320	6	D	d	NN
cord-321401-w4ne60fn	320	7	-	-	HYPH
cord-321401-w4ne60fn	320	8	induced	induce	VBN
cord-321401-w4ne60fn	320	9	and	and	CC
cord-321401-w4ne60fn	320	10	constitutive	constitutive	JJ
cord-321401-w4ne60fn	320	11	airway	airway	NN
cord-321401-w4ne60fn	321	1	epithelial	epithelial	JJ
cord-321401-w4ne60fn	321	2	host	host	NN
cord-321401-w4ne60fn	321	3	defense	defense	NN
cord-321401-w4ne60fn	321	4	mechanisms	mechanism	NNS
cord-321401-w4ne60fn	321	5	Cigarette	Cigarette	NNP
cord-321401-w4ne60fn	321	6	smoke	smoke	VBP
cord-321401-w4ne60fn	321	7	exposure	exposure	NN
cord-321401-w4ne60fn	321	8	is	be	VBZ
cord-321401-w4ne60fn	321	9	associated	associate	VBN
cord-321401-w4ne60fn	321	10	with	with	IN
cord-321401-w4ne60fn	321	11	vitamin	vitamin	NN
cord-321401-w4ne60fn	321	12	D3	D3	NNP
cord-321401-w4ne60fn	321	13	deficiencies	deficiency	NNS
cord-321401-w4ne60fn	321	14	in	in	IN
cord-321401-w4ne60fn	321	15	patients	patient	NNS
cord-321401-w4ne60fn	321	16	with	with	IN
cord-321401-w4ne60fn	321	17	chronic	chronic	JJ
cord-321401-w4ne60fn	321	18	rhinosinusitis	rhinosinusitis	NNP
cord-321401-w4ne60fn	321	19	Effect	Effect	NNP
cord-321401-w4ne60fn	321	20	of	of	IN
cord-321401-w4ne60fn	321	21	vitamin	vitamin	NN
cord-321401-w4ne60fn	321	22	D(3	D(3	NNP
cord-321401-w4ne60fn	321	23	)	)	-RRB-
cord-321401-w4ne60fn	321	24	on	on	IN
cord-321401-w4ne60fn	321	25	the	the	DT
cord-321401-w4ne60fn	321	26	antimicrobial	antimicrobial	JJ
cord-321401-w4ne60fn	321	27	activity	activity	NN
cord-321401-w4ne60fn	321	28	of	of	IN
cord-321401-w4ne60fn	321	29	human	human	JJ
cord-321401-w4ne60fn	321	30	airway	airway	NN
cord-321401-w4ne60fn	321	31	surface	surface	NN
cord-321401-w4ne60fn	321	32	liquid	liquid	NN
cord-321401-w4ne60fn	321	33	:	:	:
cord-321401-w4ne60fn	321	34	preliminary	preliminary	JJ
cord-321401-w4ne60fn	321	35	results	result	NNS
cord-321401-w4ne60fn	321	36	of	of	IN
cord-321401-w4ne60fn	321	37	a	a	DT
cord-321401-w4ne60fn	321	38	randomised	randomised	JJ
cord-321401-w4ne60fn	321	39	placebocontrolled	placebocontrolled	JJ
cord-321401-w4ne60fn	321	40	double	double	JJ
cord-321401-w4ne60fn	321	41	-	-	HYPH
cord-321401-w4ne60fn	321	42	blind	blind	JJ
cord-321401-w4ne60fn	321	43	trial	trial	NN
cord-321401-w4ne60fn	321	44	The	the	DT
cord-321401-w4ne60fn	321	45	effect	effect	NN
cord-321401-w4ne60fn	321	46	of	of	IN
cord-321401-w4ne60fn	321	47	aspergillus	aspergillus	NN
cord-321401-w4ne60fn	321	48	fumigatus	fumigatus	NN
cord-321401-w4ne60fn	321	49	infection	infection	NN
cord-321401-w4ne60fn	321	50	on	on	IN
cord-321401-w4ne60fn	321	51	vitamin	vitamin	NN
cord-321401-w4ne60fn	321	52	D	D	NNP
cord-321401-w4ne60fn	321	53	receptor	receptor	NN
cord-321401-w4ne60fn	321	54	expression	expression	NN
cord-321401-w4ne60fn	321	55	in	in	IN
cord-321401-w4ne60fn	321	56	cystic	cystic	JJ
cord-321401-w4ne60fn	321	57	fibrosis	fibrosis	NN
cord-321401-w4ne60fn	321	58	Inhibition	Inhibition	NNP
cord-321401-w4ne60fn	321	59	of	of	IN
cord-321401-w4ne60fn	321	60	vitamin	vitamin	NN
cord-321401-w4ne60fn	321	61	d	d	NN
cord-321401-w4ne60fn	321	62	receptor	receptor	NN
cord-321401-w4ne60fn	321	63	translocation	translocation	NN
cord-321401-w4ne60fn	321	64	by	by	IN
cord-321401-w4ne60fn	321	65	cigarette	cigarette	NN
cord-321401-w4ne60fn	321	66	smoking	smoking	NN
cord-321401-w4ne60fn	321	67	extracts	extract	NNS
cord-321401-w4ne60fn	321	68	Microbiota	Microbiota	NNP
cord-321401-w4ne60fn	321	69	-	-	HYPH
cord-321401-w4ne60fn	321	70	dependent	dependent	JJ
cord-321401-w4ne60fn	321	71	induction	induction	NN
cord-321401-w4ne60fn	321	72	of	of	IN
cord-321401-w4ne60fn	321	73	colonic	colonic	JJ
cord-321401-w4ne60fn	321	74	Cyp27b1	Cyp27b1	NNP
cord-321401-w4ne60fn	322	1	Is	be	VBZ
cord-321401-w4ne60fn	322	2	associated	associate	VBN
cord-321401-w4ne60fn	322	3	with	with	IN
cord-321401-w4ne60fn	322	4	colonic	colonic	JJ
cord-321401-w4ne60fn	322	5	inflammation	inflammation	NN
cord-321401-w4ne60fn	322	6	:	:	:
cord-321401-w4ne60fn	322	7	implications	implication	NNS
cord-321401-w4ne60fn	322	8	of	of	IN
cord-321401-w4ne60fn	322	9	locally	locally	RB
cord-321401-w4ne60fn	322	10	produced	produce	VBN
cord-321401-w4ne60fn	322	11	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	CD
cord-321401-w4ne60fn	322	12	D3	D3	NNP
cord-321401-w4ne60fn	322	13	in	in	IN
cord-321401-w4ne60fn	322	14	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	322	15	regulation	regulation	NN
cord-321401-w4ne60fn	322	16	in	in	IN
cord-321401-w4ne60fn	322	17	the	the	DT
cord-321401-w4ne60fn	322	18	colon	colon	NN
cord-321401-w4ne60fn	322	19	Ancient	Ancient	NNP
cord-321401-w4ne60fn	322	20	nuclear	nuclear	JJ
cord-321401-w4ne60fn	322	21	receptor	receptor	NN
cord-321401-w4ne60fn	322	22	VDR	VDR	NNP
cord-321401-w4ne60fn	322	23	with	with	IN
cord-321401-w4ne60fn	322	24	new	new	JJ
cord-321401-w4ne60fn	322	25	functions	function	NNS
cord-321401-w4ne60fn	322	26	:	:	:
cord-321401-w4ne60fn	322	27	microbiome	microbiome	NN
cord-321401-w4ne60fn	322	28	and	and	CC
cord-321401-w4ne60fn	322	29	inflammation	inflammation	NN
cord-321401-w4ne60fn	322	30	Role	role	NN
cord-321401-w4ne60fn	322	31	of	of	IN
cord-321401-w4ne60fn	322	32	proinflammatory	proinflammatory	JJ
cord-321401-w4ne60fn	322	33	cytokines	cytokine	NNS
cord-321401-w4ne60fn	322	34	on	on	IN
cord-321401-w4ne60fn	322	35	expression	expression	NN
cord-321401-w4ne60fn	322	36	of	of	IN
cord-321401-w4ne60fn	322	37	vitamin	vitamin	NN
cord-321401-w4ne60fn	322	38	D	d	NN
cord-321401-w4ne60fn	322	39	metabolism	metabolism	NN
cord-321401-w4ne60fn	322	40	and	and	CC
cord-321401-w4ne60fn	322	41	target	target	VB
cord-321401-w4ne60fn	322	42	genes	gene	NNS
cord-321401-w4ne60fn	322	43	in	in	IN
cord-321401-w4ne60fn	322	44	colon	colon	NN
cord-321401-w4ne60fn	322	45	cancer	cancer	NN
cord-321401-w4ne60fn	322	46	cells	cell	NNS
cord-321401-w4ne60fn	322	47	Regulation	regulation	NN
cord-321401-w4ne60fn	322	48	of	of	IN
cord-321401-w4ne60fn	322	49	CYP27B1	cyp27b1	NN
cord-321401-w4ne60fn	322	50	and	and	CC
cord-321401-w4ne60fn	322	51	CYP24A1	cyp24a1	NN
cord-321401-w4ne60fn	322	52	gene	gene	NN
cord-321401-w4ne60fn	322	53	expression	expression	NN
cord-321401-w4ne60fn	322	54	by	by	IN
cord-321401-w4ne60fn	322	55	recombinant	recombinant	JJ
cord-321401-w4ne60fn	322	56	pro	pro	JJ
cord-321401-w4ne60fn	322	57	-	-	JJ
cord-321401-w4ne60fn	322	58	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	322	59	cytokines	cytokine	NNS
cord-321401-w4ne60fn	322	60	in	in	IN
cord-321401-w4ne60fn	322	61	cultured	cultured	JJ
cord-321401-w4ne60fn	322	62	human	human	JJ
cord-321401-w4ne60fn	322	63	trophoblasts	trophoblast	NNS
cord-321401-w4ne60fn	323	1	Toll	toll	NN
cord-321401-w4ne60fn	323	2	-	-	HYPH
cord-321401-w4ne60fn	323	3	like	like	JJ
cord-321401-w4ne60fn	323	4	receptor	receptor	NN
cord-321401-w4ne60fn	323	5	8	8	CD
cord-321401-w4ne60fn	323	6	ligands	ligand	NNS
cord-321401-w4ne60fn	323	7	activate	activate	VBP
cord-321401-w4ne60fn	323	8	a	a	DT
cord-321401-w4ne60fn	323	9	vitamin	vitamin	NN
cord-321401-w4ne60fn	323	10	D	d	NN
cord-321401-w4ne60fn	323	11	mediated	mediate	VBN
cord-321401-w4ne60fn	323	12	autophagic	autophagic	JJ
cord-321401-w4ne60fn	323	13	response	response	NN
cord-321401-w4ne60fn	323	14	that	that	WDT
cord-321401-w4ne60fn	323	15	inhibits	inhibit	VBZ
cord-321401-w4ne60fn	323	16	human	human	JJ
cord-321401-w4ne60fn	323	17	immunodeficiency	immunodeficiency	NN
cord-321401-w4ne60fn	323	18	virus	virus	NN
cord-321401-w4ne60fn	323	19	type	type	NN
cord-321401-w4ne60fn	324	1	1	1	LS
cord-321401-w4ne60fn	324	2	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	CD
cord-321401-w4ne60fn	324	3	D	d	NN
cord-321401-w4ne60fn	324	4	modulates	modulate	VBZ
cord-321401-w4ne60fn	324	5	antibacterial	antibacterial	JJ
cord-321401-w4ne60fn	324	6	and	and	CC
cord-321401-w4ne60fn	324	7	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	324	8	response	response	NN
cord-321401-w4ne60fn	324	9	in	in	IN
cord-321401-w4ne60fn	324	10	human	human	JJ
cord-321401-w4ne60fn	324	11	cigarette	cigarette	NN
cord-321401-w4ne60fn	324	12	smoke	smoke	NN
cord-321401-w4ne60fn	324	13	-	-	HYPH
cord-321401-w4ne60fn	324	14	exposed	expose	VBN
cord-321401-w4ne60fn	324	15	macrophages	macrophage	NNS
cord-321401-w4ne60fn	325	1	The	the	DT
cord-321401-w4ne60fn	325	2	aryl	aryl	NN
cord-321401-w4ne60fn	325	3	hydrocarbon	hydrocarbon	NN
cord-321401-w4ne60fn	325	4	receptor	receptor	NN
cord-321401-w4ne60fn	325	5	activator	activator	NN
cord-321401-w4ne60fn	325	6	benzo[a]pyrene	benzo[a]pyrene	NN
cord-321401-w4ne60fn	325	7	enhances	enhance	VBZ
cord-321401-w4ne60fn	325	8	vitamin	vitamin	NN
cord-321401-w4ne60fn	325	9	d3	d3	NNP
cord-321401-w4ne60fn	325	10	catabolism	catabolism	NN
cord-321401-w4ne60fn	325	11	in	in	IN
cord-321401-w4ne60fn	325	12	macrophages	macrophage	NNS
cord-321401-w4ne60fn	325	13	Toll	toll	NN
cord-321401-w4ne60fn	325	14	-	-	HYPH
cord-321401-w4ne60fn	325	15	Like	like	JJ
cord-321401-w4ne60fn	325	16	receptor	receptor	NN
cord-321401-w4ne60fn	325	17	triggering	triggering	NN
cord-321401-w4ne60fn	325	18	of	of	IN
cord-321401-w4ne60fn	325	19	a	a	DT
cord-321401-w4ne60fn	325	20	vitamin	vitamin	NN
cord-321401-w4ne60fn	325	21	d	d	XX
cord-321401-w4ne60fn	325	22	-	-	HYPH
cord-321401-w4ne60fn	325	23	mediated	mediate	VBN
cord-321401-w4ne60fn	325	24	human	human	JJ
cord-321401-w4ne60fn	325	25	antimicrobial	antimicrobial	JJ
cord-321401-w4ne60fn	325	26	response	response	NN
cord-321401-w4ne60fn	325	27	Vitamin	Vitamin	NNP
cord-321401-w4ne60fn	325	28	d	d	NN
cord-321401-w4ne60fn	325	29	-	-	HYPH
cord-321401-w4ne60fn	325	30	directed	direct	VBN
cord-321401-w4ne60fn	325	31	rheostatic	rheostatic	JJ
cord-321401-w4ne60fn	325	32	regulation	regulation	NN
cord-321401-w4ne60fn	325	33	of	of	IN
cord-321401-w4ne60fn	325	34	monocyte	monocyte	NNP
cord-321401-w4ne60fn	325	35	antibacterial	antibacterial	JJ
cord-321401-w4ne60fn	325	36	responses	response	NNS
cord-321401-w4ne60fn	325	37	IL-15	IL-15	NNP
cord-321401-w4ne60fn	325	38	links	link	VBZ
cord-321401-w4ne60fn	325	39	TLR2/1-induced	tlr2/1-induced	CD
cord-321401-w4ne60fn	325	40	macrophage	macrophage	NN
cord-321401-w4ne60fn	325	41	differentiation	differentiation	NN
cord-321401-w4ne60fn	325	42	to	to	IN
cord-321401-w4ne60fn	325	43	the	the	DT
cord-321401-w4ne60fn	325	44	vitamin	vitamin	NN
cord-321401-w4ne60fn	325	45	D	d	NN
cord-321401-w4ne60fn	325	46	-	-	HYPH
cord-321401-w4ne60fn	325	47	dependent	dependent	JJ
cord-321401-w4ne60fn	325	48	antimicrobial	antimicrobial	JJ
cord-321401-w4ne60fn	325	49	pathway	pathway	NN
cord-321401-w4ne60fn	325	50	Vitamin	vitamin	NN
cord-321401-w4ne60fn	325	51	D	d	NN
cord-321401-w4ne60fn	326	1	promotes	promote	VBZ
cord-321401-w4ne60fn	326	2	pneumococcal	pneumococcal	JJ
cord-321401-w4ne60fn	326	3	killing	killing	NN
cord-321401-w4ne60fn	326	4	and	and	CC
cord-321401-w4ne60fn	326	5	modulates	modulate	VBZ
cord-321401-w4ne60fn	326	6	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	326	7	responses	response	NNS
cord-321401-w4ne60fn	326	8	in	in	IN
cord-321401-w4ne60fn	326	9	primary	primary	JJ
cord-321401-w4ne60fn	326	10	human	human	JJ
cord-321401-w4ne60fn	326	11	neutrophils	neutrophil	NNS
cord-321401-w4ne60fn	326	12	Human	Human	NNP
cord-321401-w4ne60fn	326	13	T	T	NNP
cord-321401-w4ne60fn	326	14	lymphocytes	lymphocyte	NNS
cord-321401-w4ne60fn	327	1	are	be	VBP
cord-321401-w4ne60fn	327	2	direct	direct	JJ
cord-321401-w4ne60fn	327	3	targets	target	NNS
cord-321401-w4ne60fn	327	4	of	of	IN
cord-321401-w4ne60fn	327	5	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	CD
cord-321401-w4ne60fn	327	6	D3	D3	NNP
cord-321401-w4ne60fn	327	7	in	in	IN
cord-321401-w4ne60fn	327	8	the	the	DT
cord-321401-w4ne60fn	327	9	immune	immune	JJ
cord-321401-w4ne60fn	327	10	system	system	NN
cord-321401-w4ne60fn	327	11	Modulatory	modulatory	JJ
cord-321401-w4ne60fn	327	12	effects	effect	NNS
cord-321401-w4ne60fn	327	13	of	of	IN
cord-321401-w4ne60fn	327	14	1,25-Dihydroxyvitamin	1,25-dihydroxyvitamin	CD
cord-321401-w4ne60fn	327	15	D	d	NN
cord-321401-w4ne60fn	327	16	3	3	CD
cord-321401-w4ne60fn	327	17	on	on	IN
cord-321401-w4ne60fn	327	18	human	human	JJ
cord-321401-w4ne60fn	327	19	B	b	NN
cord-321401-w4ne60fn	327	20	cell	cell	NN
cord-321401-w4ne60fn	327	21	differentiation	differentiation	NN
cord-321401-w4ne60fn	327	22	In	in	IN
cord-321401-w4ne60fn	327	23	the	the	DT
cord-321401-w4ne60fn	327	24	shadow	shadow	NN
cord-321401-w4ne60fn	327	25	of	of	IN
cord-321401-w4ne60fn	327	26	fibrosis	fibrosis	NN
cord-321401-w4ne60fn	327	27	:	:	:
cord-321401-w4ne60fn	328	1	innate	innate	JJ
cord-321401-w4ne60fn	328	2	immune	immune	JJ
cord-321401-w4ne60fn	328	3	suppression	suppression	NN
cord-321401-w4ne60fn	328	4	mediated	mediate	VBN
cord-321401-w4ne60fn	328	5	by	by	IN
cord-321401-w4ne60fn	328	6	transforming	transform	VBG
cord-321401-w4ne60fn	328	7	growth	growth	NN
cord-321401-w4ne60fn	328	8	factor	factor	NN
cord-321401-w4ne60fn	328	9	-	-	HYPH
cord-321401-w4ne60fn	328	10	β	β	NN
cord-321401-w4ne60fn	328	11	Targeting	target	VBG
cord-321401-w4ne60fn	328	12	cytokines	cytokine	NNS
cord-321401-w4ne60fn	328	13	to	to	TO
cord-321401-w4ne60fn	328	14	treat	treat	VB
cord-321401-w4ne60fn	328	15	asthma	asthma	NN
cord-321401-w4ne60fn	328	16	and	and	CC
cord-321401-w4ne60fn	328	17	chronic	chronic	JJ
cord-321401-w4ne60fn	328	18	obstructive	obstructive	JJ
cord-321401-w4ne60fn	328	19	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	328	20	disease	disease	NN
cord-321401-w4ne60fn	328	21	COPD	COPD	NNP
cord-321401-w4ne60fn	328	22	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	328	23	:	:	:
cord-321401-w4ne60fn	328	24	defining	define	VBG
cord-321401-w4ne60fn	328	25	their	-PRON-	PRP$
cord-321401-w4ne60fn	328	26	cause	cause	NN
cord-321401-w4ne60fn	328	27	and	and	CC
cord-321401-w4ne60fn	328	28	prevention	prevention	NN
cord-321401-w4ne60fn	328	29	Phenotypic	phenotypic	JJ
cord-321401-w4ne60fn	328	30	and	and	CC
cord-321401-w4ne60fn	328	31	genetic	genetic	JJ
cord-321401-w4ne60fn	328	32	aspects	aspect	NNS
cord-321401-w4ne60fn	328	33	of	of	IN
cord-321401-w4ne60fn	328	34	epithelial	epithelial	JJ
cord-321401-w4ne60fn	328	35	barrier	barrier	NN
cord-321401-w4ne60fn	328	36	function	function	NN
cord-321401-w4ne60fn	328	37	in	in	IN
cord-321401-w4ne60fn	328	38	asthmatic	asthmatic	JJ
cord-321401-w4ne60fn	328	39	patients	patient	NNS
cord-321401-w4ne60fn	329	1	Recent	recent	JJ
cord-321401-w4ne60fn	329	2	advances	advance	NNS
cord-321401-w4ne60fn	329	3	in	in	IN
cord-321401-w4ne60fn	329	4	the	the	DT
cord-321401-w4ne60fn	329	5	understanding	understanding	NN
cord-321401-w4ne60fn	329	6	and	and	CC
cord-321401-w4ne60fn	329	7	management	management	NN
cord-321401-w4ne60fn	329	8	of	of	IN
cord-321401-w4ne60fn	329	9	cystic	cystic	JJ
cord-321401-w4ne60fn	329	10	fibrosis	fibrosis	NN
cord-321401-w4ne60fn	329	11	pulmonary	pulmonary	NNP
cord-321401-w4ne60fn	329	12	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	330	1	Interleukin	interleukin	NN
cord-321401-w4ne60fn	330	2	13	13	CD
cord-321401-w4ne60fn	330	3	exposure	exposure	NN
cord-321401-w4ne60fn	330	4	enhances	enhance	VBZ
cord-321401-w4ne60fn	330	5	vitamin	vitamin	NN
cord-321401-w4ne60fn	330	6	D	d	NN
cord-321401-w4ne60fn	330	7	-	-	HYPH
cord-321401-w4ne60fn	330	8	mediated	mediate	VBN
cord-321401-w4ne60fn	330	9	expression	expression	NN
cord-321401-w4ne60fn	330	10	of	of	IN
cord-321401-w4ne60fn	330	11	the	the	DT
cord-321401-w4ne60fn	330	12	human	human	JJ
cord-321401-w4ne60fn	330	13	cathelicidin	cathelicidin	NNP
cord-321401-w4ne60fn	330	14	antimicrobial	antimicrobial	NNP
cord-321401-w4ne60fn	330	15	peptide	peptide	NNP
cord-321401-w4ne60fn	330	16	18	18	CD
cord-321401-w4ne60fn	330	17	/	/	SYM
cord-321401-w4ne60fn	330	18	LL-37	LL-37	NNP
cord-321401-w4ne60fn	330	19	in	in	IN
cord-321401-w4ne60fn	330	20	bronchial	bronchial	JJ
cord-321401-w4ne60fn	330	21	epithelial	epithelial	JJ
cord-321401-w4ne60fn	330	22	cells	cell	NNS
cord-321401-w4ne60fn	330	23	Association	Association	NNP
cord-321401-w4ne60fn	330	24	of	of	IN
cord-321401-w4ne60fn	330	25	vitamin	vitamin	NN
cord-321401-w4ne60fn	330	26	D	D	NNP
cord-321401-w4ne60fn	330	27	and	and	CC
cord-321401-w4ne60fn	330	28	antimicrobial	antimicrobial	JJ
cord-321401-w4ne60fn	330	29	peptide	peptide	NN
cord-321401-w4ne60fn	330	30	production	production	NN
cord-321401-w4ne60fn	330	31	during	during	IN
cord-321401-w4ne60fn	330	32	late	late	JJ
cord-321401-w4ne60fn	330	33	-	-	HYPH
cord-321401-w4ne60fn	330	34	phase	phase	NN
cord-321401-w4ne60fn	330	35	allergic	allergic	JJ
cord-321401-w4ne60fn	330	36	responses	response	NNS
cord-321401-w4ne60fn	330	37	in	in	IN
cord-321401-w4ne60fn	330	38	the	the	DT
cord-321401-w4ne60fn	330	39	lung	lung	NN
cord-321401-w4ne60fn	330	40	Low	Low	NNP
cord-321401-w4ne60fn	330	41	serum	serum	NN
cord-321401-w4ne60fn	330	42	vitamin	vitamin	NN
cord-321401-w4ne60fn	330	43	D	d	NN
cord-321401-w4ne60fn	330	44	-	-	HYPH
cord-321401-w4ne60fn	330	45	status	status	NN
cord-321401-w4ne60fn	330	46	,	,	,
cord-321401-w4ne60fn	330	47	air	air	NN
cord-321401-w4ne60fn	330	48	pollution	pollution	NN
cord-321401-w4ne60fn	330	49	and	and	CC
cord-321401-w4ne60fn	330	50	obesity	obesity	NN
cord-321401-w4ne60fn	330	51	:	:	:
cord-321401-w4ne60fn	330	52	a	a	DT
cord-321401-w4ne60fn	330	53	dangerous	dangerous	JJ
cord-321401-w4ne60fn	330	54	liaison	liaison	NN
cord-321401-w4ne60fn	330	55	Vitamin	vitamin	NN
cord-321401-w4ne60fn	330	56	D	D	NNP
cord-321401-w4ne60fn	330	57	prevents	prevent	VBZ
cord-321401-w4ne60fn	330	58	experimental	experimental	JJ
cord-321401-w4ne60fn	330	59	lung	lung	NN
cord-321401-w4ne60fn	330	60	fibrosis	fibrosis	NN
cord-321401-w4ne60fn	330	61	and	and	CC
cord-321401-w4ne60fn	330	62	predicts	predict	VBZ
cord-321401-w4ne60fn	330	63	survival	survival	NN
cord-321401-w4ne60fn	330	64	in	in	IN
cord-321401-w4ne60fn	330	65	patients	patient	NNS
cord-321401-w4ne60fn	330	66	with	with	IN
cord-321401-w4ne60fn	330	67	idiopathic	idiopathic	JJ
cord-321401-w4ne60fn	330	68	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	330	69	fibrosis	fibrosis	NN
cord-321401-w4ne60fn	330	70	Reduced	reduce	VBN
cord-321401-w4ne60fn	330	71	sinonasal	sinonasal	NN
cord-321401-w4ne60fn	330	72	levels	level	NNS
cord-321401-w4ne60fn	330	73	of	of	IN
cord-321401-w4ne60fn	330	74	1alpha	1alpha	CD
cord-321401-w4ne60fn	330	75	-	-	HYPH
cord-321401-w4ne60fn	330	76	hydroxylase	hydroxylase	NN
cord-321401-w4ne60fn	330	77	are	be	VBP
cord-321401-w4ne60fn	330	78	associated	associate	VBN
cord-321401-w4ne60fn	330	79	with	with	IN
cord-321401-w4ne60fn	330	80	worse	bad	JJR
cord-321401-w4ne60fn	330	81	quality	quality	NN
cord-321401-w4ne60fn	330	82	of	of	IN
cord-321401-w4ne60fn	330	83	life	life	NN
cord-321401-w4ne60fn	330	84	in	in	IN
cord-321401-w4ne60fn	330	85	chronic	chronic	JJ
cord-321401-w4ne60fn	330	86	rhinosinusitis	rhinosinusitis	NN
cord-321401-w4ne60fn	330	87	with	with	IN
cord-321401-w4ne60fn	330	88	nasal	nasal	NN
cord-321401-w4ne60fn	330	89	polyps	polyp	NNS
cord-321401-w4ne60fn	330	90	Vitamin	vitamin	NN
cord-321401-w4ne60fn	330	91	D	d	NN
cord-321401-w4ne60fn	330	92	and	and	CC
cord-321401-w4ne60fn	330	93	musculoskeletal	musculoskeletal	JJ
cord-321401-w4ne60fn	330	94	health	health	NN
cord-321401-w4ne60fn	330	95	,	,	,
cord-321401-w4ne60fn	330	96	cardiovascular	cardiovascular	JJ
cord-321401-w4ne60fn	330	97	disease	disease	NN
cord-321401-w4ne60fn	330	98	,	,	,
cord-321401-w4ne60fn	330	99	autoimmunity	autoimmunity	NN
cord-321401-w4ne60fn	330	100	and	and	CC
cord-321401-w4ne60fn	330	101	cancer	cancer	NN
cord-321401-w4ne60fn	330	102	:	:	:
cord-321401-w4ne60fn	330	103	recommendations	recommendation	NNS
cord-321401-w4ne60fn	330	104	for	for	IN
cord-321401-w4ne60fn	330	105	clinical	clinical	JJ
cord-321401-w4ne60fn	330	106	practice	practice	NN
cord-321401-w4ne60fn	330	107	Review	Review	NNP
cord-321401-w4ne60fn	330	108	:	:	:
cord-321401-w4ne60fn	330	109	The	the	DT
cord-321401-w4ne60fn	330	110	role	role	NN
cord-321401-w4ne60fn	330	111	of	of	IN
cord-321401-w4ne60fn	330	112	vitamin	vitamin	NN
cord-321401-w4ne60fn	330	113	D	d	NN
cord-321401-w4ne60fn	330	114	in	in	IN
cord-321401-w4ne60fn	330	115	nervous	nervous	JJ
cord-321401-w4ne60fn	330	116	system	system	NN
cord-321401-w4ne60fn	330	117	health	health	NN
cord-321401-w4ne60fn	330	118	and	and	CC
cord-321401-w4ne60fn	330	119	disease	disease	NN
cord-321401-w4ne60fn	330	120	Vitamin	vitamin	NN
cord-321401-w4ne60fn	330	121	D	d	NN
cord-321401-w4ne60fn	330	122	in	in	IN
cord-321401-w4ne60fn	330	123	autoimmunity	autoimmunity	NN
cord-321401-w4ne60fn	330	124	:	:	:
cord-321401-w4ne60fn	330	125	molecular	molecular	JJ
cord-321401-w4ne60fn	330	126	mechanisms	mechanism	NNS
cord-321401-w4ne60fn	330	127	and	and	CC
cord-321401-w4ne60fn	330	128	therapeutic	therapeutic	JJ
cord-321401-w4ne60fn	330	129	potential	potential	NN
cord-321401-w4ne60fn	330	130	.	.	.
cord-321401-w4ne60fn	331	1	Front	Front	NNP
cord-321401-w4ne60fn	331	2	Immunol	Immunol	NNP
cord-321401-w4ne60fn	331	3	Vitamin	vitamin	NN
cord-321401-w4ne60fn	331	4	D	d	NN
cord-321401-w4ne60fn	331	5	cell	cell	NN
cord-321401-w4ne60fn	331	6	signalling	signal	VBG
cord-321401-w4ne60fn	331	7	in	in	IN
cord-321401-w4ne60fn	331	8	health	health	NN
cord-321401-w4ne60fn	331	9	and	and	CC
cord-321401-w4ne60fn	331	10	disease	disease	NN
cord-321401-w4ne60fn	331	11	Airway	airway	NN
cord-321401-w4ne60fn	331	12	epithelial	epithelial	JJ
cord-321401-w4ne60fn	331	13	barrier	barrier	NN
cord-321401-w4ne60fn	331	14	dysfunction	dysfunction	NN
cord-321401-w4ne60fn	331	15	in	in	IN
cord-321401-w4ne60fn	331	16	chronic	chronic	JJ
cord-321401-w4ne60fn	331	17	obstructive	obstructive	JJ
cord-321401-w4ne60fn	331	18	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	331	19	disease	disease	NN
cord-321401-w4ne60fn	331	20	:	:	:
cord-321401-w4ne60fn	331	21	role	role	NN
cord-321401-w4ne60fn	331	22	of	of	IN
cord-321401-w4ne60fn	331	23	cigarette	cigarette	NN
cord-321401-w4ne60fn	331	24	smoke	smoke	NN
cord-321401-w4ne60fn	331	25	exposure	exposure	NN
cord-321401-w4ne60fn	331	26	25-Dihydroxyvitamin	25-dihydroxyvitamin	CD
cord-321401-w4ne60fn	331	27	D3	D3	NNP
cord-321401-w4ne60fn	331	28	counteracts	counteract	VBZ
cord-321401-w4ne60fn	331	29	the	the	DT
cord-321401-w4ne60fn	331	30	effects	effect	NNS
cord-321401-w4ne60fn	331	31	of	of	IN
cord-321401-w4ne60fn	331	32	cigarette	cigarette	NN
cord-321401-w4ne60fn	331	33	smoke	smoke	NN
cord-321401-w4ne60fn	331	34	in	in	IN
cord-321401-w4ne60fn	331	35	airway	airway	JJ
cord-321401-w4ne60fn	331	36	epithelial	epithelial	JJ
cord-321401-w4ne60fn	331	37	cells	cell	NNS
cord-321401-w4ne60fn	331	38	Vitamin	vitamin	NN
cord-321401-w4ne60fn	331	39	D	d	NN
cord-321401-w4ne60fn	331	40	/	/	SYM
cord-321401-w4ne60fn	331	41	VDR	VDR	NNP
cord-321401-w4ne60fn	331	42	signaling	signal	VBG
cord-321401-w4ne60fn	331	43	attenuates	attenuate	VBZ
cord-321401-w4ne60fn	331	44	lipopolysaccharide	lipopolysaccharide	NN
cord-321401-w4ne60fn	331	45	-	-	HYPH
cord-321401-w4ne60fn	331	46	induced	induce	VBN
cord-321401-w4ne60fn	331	47	acute	acute	JJ
cord-321401-w4ne60fn	331	48	lung	lung	NN
cord-321401-w4ne60fn	331	49	injury	injury	NN
cord-321401-w4ne60fn	331	50	by	by	IN
cord-321401-w4ne60fn	331	51	maintaining	maintain	VBG
cord-321401-w4ne60fn	331	52	the	the	DT
cord-321401-w4ne60fn	331	53	integrity	integrity	NN
cord-321401-w4ne60fn	331	54	of	of	IN
cord-321401-w4ne60fn	331	55	the	the	DT
cord-321401-w4ne60fn	331	56	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	331	57	epithelial	epithelial	JJ
cord-321401-w4ne60fn	331	58	barrier	barrier	NN
cord-321401-w4ne60fn	331	59	Vitamin	vitamin	NN
cord-321401-w4ne60fn	331	60	D	d	NN
cord-321401-w4ne60fn	331	61	supplementation	supplementation	NN
cord-321401-w4ne60fn	331	62	of	of	IN
cord-321401-w4ne60fn	331	63	initially	initially	RB
cord-321401-w4ne60fn	331	64	vitamin	vitamin	NN
cord-321401-w4ne60fn	331	65	D	d	NN
cord-321401-w4ne60fn	331	66	-	-	HYPH
cord-321401-w4ne60fn	331	67	deficient	deficient	JJ
cord-321401-w4ne60fn	331	68	mice	mice	NN
cord-321401-w4ne60fn	331	69	diminishes	diminish	VBZ
cord-321401-w4ne60fn	331	70	lung	lung	NN
cord-321401-w4ne60fn	331	71	inflammation	inflammation	NN
cord-321401-w4ne60fn	331	72	with	with	IN
cord-321401-w4ne60fn	331	73	limited	limited	JJ
cord-321401-w4ne60fn	331	74	effects	effect	NNS
cord-321401-w4ne60fn	331	75	on	on	IN
cord-321401-w4ne60fn	331	76	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	331	77	epithelial	epithelial	JJ
cord-321401-w4ne60fn	331	78	integrity	integrity	NN
cord-321401-w4ne60fn	331	79	Inflammation	inflammation	NN
cord-321401-w4ne60fn	331	80	and	and	CC
cord-321401-w4ne60fn	331	81	the	the	DT
cord-321401-w4ne60fn	331	82	intestinal	intestinal	JJ
cord-321401-w4ne60fn	331	83	barrier	barrier	NN
cord-321401-w4ne60fn	331	84	:	:	:
cord-321401-w4ne60fn	331	85	leukocyte	leukocyte	NN
cord-321401-w4ne60fn	331	86	-	-	HYPH
cord-321401-w4ne60fn	331	87	epithelial	epithelial	JJ
cord-321401-w4ne60fn	331	88	cell	cell	NN
cord-321401-w4ne60fn	331	89	interactions	interaction	NNS
cord-321401-w4ne60fn	331	90	,	,	,
cord-321401-w4ne60fn	331	91	cell	cell	NN
cord-321401-w4ne60fn	331	92	junction	junction	NN
cord-321401-w4ne60fn	331	93	remodeling	remodeling	NN
cord-321401-w4ne60fn	331	94	,	,	,
cord-321401-w4ne60fn	331	95	mucosal	mucosal	JJ
cord-321401-w4ne60fn	331	96	repair	repair	NN
cord-321401-w4ne60fn	332	1	Reduced	reduce	VBN
cord-321401-w4ne60fn	332	2	airway	airway	NN
cord-321401-w4ne60fn	332	3	surface	surface	NN
cord-321401-w4ne60fn	332	4	pH	ph	NN
cord-321401-w4ne60fn	332	5	impairs	impair	VBZ
cord-321401-w4ne60fn	332	6	bacterial	bacterial	JJ
cord-321401-w4ne60fn	332	7	killing	killing	NN
cord-321401-w4ne60fn	332	8	in	in	IN
cord-321401-w4ne60fn	332	9	the	the	DT
cord-321401-w4ne60fn	332	10	porcine	porcine	JJ
cord-321401-w4ne60fn	332	11	cystic	cystic	JJ
cord-321401-w4ne60fn	332	12	fibrosis	fibrosis	NN
cord-321401-w4ne60fn	332	13	lung	lung	NN
cord-321401-w4ne60fn	332	14	Cigarette	Cigarette	NNP
cord-321401-w4ne60fn	332	15	smoke	smoke	NN
cord-321401-w4ne60fn	332	16	and	and	CC
cord-321401-w4ne60fn	332	17	CFTR	CFTR	NNP
cord-321401-w4ne60fn	332	18	:	:	:
cord-321401-w4ne60fn	333	1	implications	implication	NNS
cord-321401-w4ne60fn	333	2	in	in	IN
cord-321401-w4ne60fn	333	3	the	the	DT
cord-321401-w4ne60fn	333	4	pathogenesis	pathogenesis	NN
cord-321401-w4ne60fn	333	5	of	of	IN
cord-321401-w4ne60fn	333	6	COPD	COPD	NNP
cord-321401-w4ne60fn	333	7	Molecular	Molecular	NNP
cord-321401-w4ne60fn	333	8	mechanisms	mechanism	NNS
cord-321401-w4ne60fn	333	9	of	of	IN
cord-321401-w4ne60fn	333	10	epithelialmesenchymal	epithelialmesenchymal	NNP
cord-321401-w4ne60fn	333	11	transition	transition	NN
cord-321401-w4ne60fn	333	12	Epithelial	epithelial	JJ
cord-321401-w4ne60fn	333	13	to	to	IN
cord-321401-w4ne60fn	333	14	mesenchymal	mesenchymal	JJ
cord-321401-w4ne60fn	333	15	transition	transition	NN
cord-321401-w4ne60fn	333	16	is	be	VBZ
cord-321401-w4ne60fn	333	17	increased	increase	VBN
cord-321401-w4ne60fn	333	18	in	in	IN
cord-321401-w4ne60fn	333	19	patients	patient	NNS
cord-321401-w4ne60fn	333	20	with	with	IN
cord-321401-w4ne60fn	333	21	COPD	COPD	NNP
cord-321401-w4ne60fn	333	22	and	and	CC
cord-321401-w4ne60fn	333	23	induced	induce	VBN
cord-321401-w4ne60fn	333	24	by	by	IN
cord-321401-w4ne60fn	333	25	cigarette	cigarette	NN
cord-321401-w4ne60fn	333	26	smoke	smoke	NN
cord-321401-w4ne60fn	333	27	Vitamin	vitamin	NN
cord-321401-w4ne60fn	333	28	D	d	NN
cord-321401-w4ne60fn	334	1	inhibits	inhibit	VBZ
cord-321401-w4ne60fn	334	2	the	the	DT
cord-321401-w4ne60fn	334	3	epithelial	epithelial	NN
cord-321401-w4ne60fn	334	4	-	-	HYPH
cord-321401-w4ne60fn	334	5	mesenchymal	mesenchymal	JJ
cord-321401-w4ne60fn	334	6	transition	transition	NN
cord-321401-w4ne60fn	334	7	by	by	IN
cord-321401-w4ne60fn	334	8	a	a	DT
cord-321401-w4ne60fn	334	9	negative	negative	JJ
cord-321401-w4ne60fn	334	10	feedback	feedback	NN
cord-321401-w4ne60fn	334	11	regulation	regulation	NN
cord-321401-w4ne60fn	334	12	of	of	IN
cord-321401-w4ne60fn	334	13	TGF	TGF	NNP
cord-321401-w4ne60fn	334	14	-	-	HYPH
cord-321401-w4ne60fn	334	15	β	β	NN
cord-321401-w4ne60fn	334	16	activity	activity	NN
cord-321401-w4ne60fn	335	1	25-dihydroxyvitamin	25-dihydroxyvitamin	CD
cord-321401-w4ne60fn	335	2	D3	D3	NNP
cord-321401-w4ne60fn	335	3	attenuates	attenuate	VBZ
cord-321401-w4ne60fn	336	1	TGF	TGF	NNP
cord-321401-w4ne60fn	336	2	-	-	HYPH
cord-321401-w4ne60fn	336	3	β	β	NN
cord-321401-w4ne60fn	336	4	-	-	HYPH
cord-321401-w4ne60fn	336	5	induced	induce	VBN
cord-321401-w4ne60fn	336	6	pro	pro	JJ
cord-321401-w4ne60fn	336	7	-	-	JJ
cord-321401-w4ne60fn	336	8	fibrotic	fibrotic	JJ
cord-321401-w4ne60fn	336	9	effects	effect	NNS
cord-321401-w4ne60fn	336	10	in	in	IN
cord-321401-w4ne60fn	336	11	human	human	JJ
cord-321401-w4ne60fn	336	12	lung	lung	NN
cord-321401-w4ne60fn	336	13	epithelial	epithelial	NN
cord-321401-w4ne60fn	336	14	cells	cell	NNS
cord-321401-w4ne60fn	336	15	through	through	IN
cord-321401-w4ne60fn	336	16	inhibition	inhibition	NN
cord-321401-w4ne60fn	336	17	of	of	IN
cord-321401-w4ne60fn	336	18	epithelial	epithelial	NN
cord-321401-w4ne60fn	336	19	-	-	HYPH
cord-321401-w4ne60fn	336	20	mesenchymal	mesenchymal	JJ
cord-321401-w4ne60fn	336	21	transition	transition	NN
cord-321401-w4ne60fn	337	1	Calcitriol	Calcitriol	NNP
cord-321401-w4ne60fn	337	2	inhibits	inhibit	VBZ
cord-321401-w4ne60fn	337	3	bleomycin	bleomycin	NN
cord-321401-w4ne60fn	337	4	-	-	HYPH
cord-321401-w4ne60fn	337	5	induced	induce	VBN
cord-321401-w4ne60fn	337	6	early	early	JJ
cord-321401-w4ne60fn	337	7	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	337	8	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	337	9	response	response	NN
cord-321401-w4ne60fn	337	10	and	and	CC
cord-321401-w4ne60fn	337	11	epithelial	epithelial	NN
cord-321401-w4ne60fn	337	12	-	-	HYPH
cord-321401-w4ne60fn	337	13	mesenchymal	mesenchymal	JJ
cord-321401-w4ne60fn	337	14	transition	transition	NN
cord-321401-w4ne60fn	337	15	in	in	IN
cord-321401-w4ne60fn	337	16	mice	mouse	NNS
cord-321401-w4ne60fn	338	1	Vitamin	vitamin	NN
cord-321401-w4ne60fn	338	2	D	d	NN
cord-321401-w4ne60fn	338	3	Supplementation	supplementation	NN
cord-321401-w4ne60fn	338	4	Reduces	reduce	VBZ
cord-321401-w4ne60fn	338	5	Induction	Induction	NNP
cord-321401-w4ne60fn	338	6	of	of	IN
cord-321401-w4ne60fn	338	7	Epithelial	Epithelial	NNP
cord-321401-w4ne60fn	338	8	-	-	HYPH
cord-321401-w4ne60fn	338	9	Mesenchymal	Mesenchymal	NNP
cord-321401-w4ne60fn	338	10	transition	transition	NN
cord-321401-w4ne60fn	338	11	in	in	IN
cord-321401-w4ne60fn	338	12	allergen	allergen	NN
cord-321401-w4ne60fn	338	13	sensitized	sensitize	VBN
cord-321401-w4ne60fn	338	14	and	and	CC
cord-321401-w4ne60fn	338	15	challenged	challenge	VBD
cord-321401-w4ne60fn	338	16	mice	mouse	NNS
cord-321401-w4ne60fn	339	1	The	the	DT
cord-321401-w4ne60fn	339	2	immunology	immunology	NN
cord-321401-w4ne60fn	339	3	of	of	IN
cord-321401-w4ne60fn	339	4	host	host	NN
cord-321401-w4ne60fn	339	5	defence	defence	NN
cord-321401-w4ne60fn	339	6	peptides	peptide	NNS
cord-321401-w4ne60fn	339	7	:	:	:
cord-321401-w4ne60fn	339	8	beyond	beyond	IN
cord-321401-w4ne60fn	339	9	antimicrobial	antimicrobial	JJ
cord-321401-w4ne60fn	339	10	activity	activity	NN
cord-321401-w4ne60fn	339	11	Cutting	cutting	NN
cord-321401-w4ne60fn	339	12	edge	edge	NN
cord-321401-w4ne60fn	340	1	:	:	:
cord-321401-w4ne60fn	340	2	1,25-Dihydroxyvitamin	1,25-dihydroxyvitamin	CD
cord-321401-w4ne60fn	340	3	D3	D3	NNP
cord-321401-w4ne60fn	340	4	is	be	VBZ
cord-321401-w4ne60fn	340	5	a	a	DT
cord-321401-w4ne60fn	340	6	direct	direct	JJ
cord-321401-w4ne60fn	340	7	inducer	inducer	NN
cord-321401-w4ne60fn	340	8	of	of	IN
cord-321401-w4ne60fn	340	9	antimicrobial	antimicrobial	JJ
cord-321401-w4ne60fn	340	10	peptide	peptide	NN
cord-321401-w4ne60fn	340	11	gene	gene	NN
cord-321401-w4ne60fn	340	12	expression	expression	NN
cord-321401-w4ne60fn	341	1	The	the	DT
cord-321401-w4ne60fn	341	2	differential	differential	JJ
cord-321401-w4ne60fn	341	3	effects	effect	NNS
cord-321401-w4ne60fn	341	4	of	of	IN
cord-321401-w4ne60fn	341	5	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	CD
cord-321401-w4ne60fn	341	6	D3	D3	NNP
cord-321401-w4ne60fn	341	7	on	on	IN
cord-321401-w4ne60fn	341	8	Salmonella	salmonella	NN
cord-321401-w4ne60fn	341	9	-	-	HYPH
cord-321401-w4ne60fn	341	10	induced	induce	VBN
cord-321401-w4ne60fn	341	11	interleukin-8	interleukin-8	NNP
cord-321401-w4ne60fn	341	12	and	and	CC
cord-321401-w4ne60fn	341	13	human	human	JJ
cord-321401-w4ne60fn	341	14	beta	beta	NN
cord-321401-w4ne60fn	341	15	-	-	HYPH
cord-321401-w4ne60fn	341	16	defensin-2	defensin-2	NN
cord-321401-w4ne60fn	341	17	in	in	IN
cord-321401-w4ne60fn	341	18	intestinal	intestinal	JJ
cord-321401-w4ne60fn	341	19	epithelial	epithelial	JJ
cord-321401-w4ne60fn	341	20	cells	cell	NNS
cord-321401-w4ne60fn	341	21	Direct	direct	JJ
cord-321401-w4ne60fn	341	22	and	and	CC
cord-321401-w4ne60fn	341	23	indirect	indirect	JJ
cord-321401-w4ne60fn	341	24	induction	induction	NN
cord-321401-w4ne60fn	341	25	by	by	IN
cord-321401-w4ne60fn	341	26	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	CD
cord-321401-w4ne60fn	341	27	D3	D3	NNP
cord-321401-w4ne60fn	341	28	of	of	IN
cord-321401-w4ne60fn	341	29	the	the	DT
cord-321401-w4ne60fn	341	30	NOD2	NOD2	NNPS
cord-321401-w4ne60fn	341	31	/	/	SYM
cord-321401-w4ne60fn	341	32	CARD15-Defensin	CARD15-Defensin	NNP
cord-321401-w4ne60fn	341	33	β2	β2	NN
cord-321401-w4ne60fn	341	34	innate	innate	VBP
cord-321401-w4ne60fn	341	35	immune	immune	JJ
cord-321401-w4ne60fn	341	36	pathway	pathway	NN
cord-321401-w4ne60fn	341	37	defective	defective	JJ
cord-321401-w4ne60fn	341	38	in	in	IN
cord-321401-w4ne60fn	341	39	crohn	crohn	NNP
cord-321401-w4ne60fn	341	40	disease	disease	NNP
cord-321401-w4ne60fn	342	1	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	CD
cord-321401-w4ne60fn	342	2	D3	D3	NNP
cord-321401-w4ne60fn	342	3	induces	induce	VBZ
cord-321401-w4ne60fn	342	4	LL-37	LL-37	NNP
cord-321401-w4ne60fn	342	5	and	and	CC
cord-321401-w4ne60fn	342	6	HBD-2	hbd-2	JJ
cord-321401-w4ne60fn	342	7	production	production	NN
cord-321401-w4ne60fn	342	8	in	in	IN
cord-321401-w4ne60fn	342	9	keratinocytes	keratinocyte	NNS
cord-321401-w4ne60fn	342	10	from	from	IN
cord-321401-w4ne60fn	342	11	diabetic	diabetic	JJ
cord-321401-w4ne60fn	342	12	foot	foot	NN
cord-321401-w4ne60fn	342	13	ulcers	ulcer	NNS
cord-321401-w4ne60fn	342	14	promoting	promote	VBG
cord-321401-w4ne60fn	342	15	wound	wound	NN
cord-321401-w4ne60fn	342	16	healing	healing	NN
cord-321401-w4ne60fn	342	17	:	:	:
cord-321401-w4ne60fn	343	1	an	an	DT
cord-321401-w4ne60fn	343	2	in	in	FW
cord-321401-w4ne60fn	343	3	vitro	vitro	FW
cord-321401-w4ne60fn	343	4	model	model	NN
cord-321401-w4ne60fn	343	5	PPARγ	PPARγ	NNS
cord-321401-w4ne60fn	343	6	mediates	mediate	VBZ
cord-321401-w4ne60fn	343	7	innate	innate	JJ
cord-321401-w4ne60fn	343	8	immunity	immunity	NN
cord-321401-w4ne60fn	343	9	by	by	IN
cord-321401-w4ne60fn	343	10	regulating	regulate	VBG
cord-321401-w4ne60fn	343	11	the	the	DT
cord-321401-w4ne60fn	343	12	1α,25-dihydroxyvitamin	1α,25-dihydroxyvitamin	CD
cord-321401-w4ne60fn	343	13	D3	D3	NNP
cord-321401-w4ne60fn	343	14	induced	induce	VBD
cord-321401-w4ne60fn	343	15	hBD-3	hBD-3	NNP
cord-321401-w4ne60fn	343	16	and	and	CC
cord-321401-w4ne60fn	343	17	cathelicidin	cathelicidin	NNS
cord-321401-w4ne60fn	343	18	in	in	IN
cord-321401-w4ne60fn	343	19	human	human	JJ
cord-321401-w4ne60fn	343	20	keratinocytes	keratinocyte	NNS
cord-321401-w4ne60fn	343	21	Cigarette	Cigarette	NNP
cord-321401-w4ne60fn	343	22	smoke	smoke	NN
cord-321401-w4ne60fn	343	23	induced	induce	VBD
cord-321401-w4ne60fn	343	24	lung	lung	NN
cord-321401-w4ne60fn	343	25	barrier	barrier	NN
cord-321401-w4ne60fn	343	26	dysfunction	dysfunction	NN
cord-321401-w4ne60fn	343	27	,	,	,
cord-321401-w4ne60fn	343	28	EMT	EMT	NNP
cord-321401-w4ne60fn	343	29	,	,	,
cord-321401-w4ne60fn	343	30	and	and	CC
cord-321401-w4ne60fn	343	31	tissue	tissue	NN
cord-321401-w4ne60fn	343	32	remodeling	remodeling	NN
cord-321401-w4ne60fn	343	33	:	:	:
cord-321401-w4ne60fn	343	34	a	a	DT
cord-321401-w4ne60fn	343	35	possible	possible	JJ
cord-321401-w4ne60fn	343	36	link	link	NN
cord-321401-w4ne60fn	343	37	between	between	IN
cord-321401-w4ne60fn	343	38	COPD	COPD	NNP
cord-321401-w4ne60fn	343	39	and	and	CC
cord-321401-w4ne60fn	343	40	lung	lung	NN
cord-321401-w4ne60fn	343	41	cancer	cancer	NN
cord-321401-w4ne60fn	343	42	Extracellular	Extracellular	NNP
cord-321401-w4ne60fn	343	43	matrix	matrix	NN
cord-321401-w4ne60fn	343	44	component	component	NN
cord-321401-w4ne60fn	343	45	remodeling	remodeling	NN
cord-321401-w4ne60fn	343	46	in	in	IN
cord-321401-w4ne60fn	343	47	respiratory	respiratory	JJ
cord-321401-w4ne60fn	343	48	diseases	disease	NNS
cord-321401-w4ne60fn	343	49	:	:	:
cord-321401-w4ne60fn	343	50	what	what	WP
cord-321401-w4ne60fn	343	51	has	have	VBZ
cord-321401-w4ne60fn	343	52	been	be	VBN
cord-321401-w4ne60fn	343	53	found	find	VBN
cord-321401-w4ne60fn	343	54	in	in	IN
cord-321401-w4ne60fn	343	55	clinical	clinical	JJ
cord-321401-w4ne60fn	343	56	and	and	CC
cord-321401-w4ne60fn	343	57	experimental	experimental	JJ
cord-321401-w4ne60fn	343	58	studies	study	NNS
cord-321401-w4ne60fn	343	59	?	?	.
cord-321401-w4ne60fn	344	1	ECM	ecm	NN
cord-321401-w4ne60fn	344	2	remodelling	remodelling	NN
cord-321401-w4ne60fn	344	3	in	in	IN
cord-321401-w4ne60fn	344	4	IBD	IBD	NNP
cord-321401-w4ne60fn	344	5	:	:	:
cord-321401-w4ne60fn	344	6	innocent	innocent	JJ
cord-321401-w4ne60fn	344	7	bystander	bystander	NN
cord-321401-w4ne60fn	344	8	or	or	CC
cord-321401-w4ne60fn	344	9	partner	partner	NN
cord-321401-w4ne60fn	344	10	in	in	IN
cord-321401-w4ne60fn	344	11	crime	crime	NN
cord-321401-w4ne60fn	344	12	?	?	.
cord-321401-w4ne60fn	345	1	The	the	DT
cord-321401-w4ne60fn	345	2	emerging	emerge	VBG
cord-321401-w4ne60fn	345	3	role	role	NN
cord-321401-w4ne60fn	345	4	of	of	IN
cord-321401-w4ne60fn	345	5	extracellular	extracellular	JJ
cord-321401-w4ne60fn	345	6	molecular	molecular	JJ
cord-321401-w4ne60fn	345	7	events	event	NNS
cord-321401-w4ne60fn	345	8	in	in	IN
cord-321401-w4ne60fn	345	9	sustaining	sustain	VBG
cord-321401-w4ne60fn	345	10	intestinal	intestinal	JJ
cord-321401-w4ne60fn	345	11	inflammation	inflammation	NN
cord-321401-w4ne60fn	345	12	Vitamin	vitamin	NN
cord-321401-w4ne60fn	345	13	D	d	NN
cord-321401-w4ne60fn	345	14	decreases	decrease	VBZ
cord-321401-w4ne60fn	345	15	respiratory	respiratory	JJ
cord-321401-w4ne60fn	345	16	syncytial	syncytial	JJ
cord-321401-w4ne60fn	345	17	virus	virus	NN
cord-321401-w4ne60fn	345	18	induction	induction	NN
cord-321401-w4ne60fn	345	19	of	of	IN
cord-321401-w4ne60fn	345	20	NF	NF	NNP
cord-321401-w4ne60fn	345	21	-	-	HYPH
cord-321401-w4ne60fn	345	22	kappaB	kappaB	NNP
cord-321401-w4ne60fn	345	23	-	-	HYPH
cord-321401-w4ne60fn	345	24	linked	link	VBN
cord-321401-w4ne60fn	345	25	chemokines	chemokine	NNS
cord-321401-w4ne60fn	345	26	and	and	CC
cord-321401-w4ne60fn	345	27	cytokines	cytokine	NNS
cord-321401-w4ne60fn	345	28	in	in	IN
cord-321401-w4ne60fn	345	29	airway	airway	NN
cord-321401-w4ne60fn	345	30	epithelium	epithelium	NN
cord-321401-w4ne60fn	345	31	while	while	IN
cord-321401-w4ne60fn	345	32	maintaining	maintain	VBG
cord-321401-w4ne60fn	345	33	the	the	DT
cord-321401-w4ne60fn	345	34	antiviral	antiviral	JJ
cord-321401-w4ne60fn	345	35	state	state	NN
cord-321401-w4ne60fn	345	36	Vitamin	vitamin	NN
cord-321401-w4ne60fn	345	37	D	d	NN
cord-321401-w4ne60fn	345	38	enhances	enhance	VBZ
cord-321401-w4ne60fn	345	39	production	production	NN
cord-321401-w4ne60fn	345	40	of	of	IN
cord-321401-w4ne60fn	345	41	soluble	soluble	JJ
cord-321401-w4ne60fn	345	42	ST2	ST2	NNP
cord-321401-w4ne60fn	345	43	,	,	,
cord-321401-w4ne60fn	345	44	inhibiting	inhibit	VBG
cord-321401-w4ne60fn	345	45	the	the	DT
cord-321401-w4ne60fn	345	46	action	action	NN
cord-321401-w4ne60fn	345	47	of	of	IN
cord-321401-w4ne60fn	345	48	IL-33	IL-33	NNP
cord-321401-w4ne60fn	345	49	Regulation	Regulation	NNP
cord-321401-w4ne60fn	345	50	of	of	IN
cord-321401-w4ne60fn	345	51	immune	immune	JJ
cord-321401-w4ne60fn	345	52	function	function	NN
cord-321401-w4ne60fn	345	53	by	by	IN
cord-321401-w4ne60fn	345	54	vitamin	vitamin	NN
cord-321401-w4ne60fn	345	55	D	d	NN
cord-321401-w4ne60fn	345	56	and	and	CC
cord-321401-w4ne60fn	345	57	Its	-PRON-	PRP$
cord-321401-w4ne60fn	345	58	use	use	NN
cord-321401-w4ne60fn	345	59	in	in	IN
cord-321401-w4ne60fn	345	60	diseases	disease	NNS
cord-321401-w4ne60fn	345	61	of	of	IN
cord-321401-w4ne60fn	345	62	immunity	immunity	NN
cord-321401-w4ne60fn	345	63	Vitamin	vitamin	NN
cord-321401-w4ne60fn	345	64	D	d	NN
cord-321401-w4ne60fn	345	65	in	in	IN
cord-321401-w4ne60fn	345	66	asthma	asthma	NN
cord-321401-w4ne60fn	345	67	:	:	:
cord-321401-w4ne60fn	346	1	mechanisms	mechanism	NNS
cord-321401-w4ne60fn	346	2	of	of	IN
cord-321401-w4ne60fn	346	3	action	action	NN
cord-321401-w4ne60fn	346	4	and	and	CC
cord-321401-w4ne60fn	346	5	considerations	consideration	NNS
cord-321401-w4ne60fn	346	6	for	for	IN
cord-321401-w4ne60fn	346	7	clinical	clinical	JJ
cord-321401-w4ne60fn	346	8	trials	trial	NNS
cord-321401-w4ne60fn	346	9	Accelerated	accelerate	VBN
cord-321401-w4ne60fn	346	10	ageing	age	VBG
cord-321401-w4ne60fn	346	11	of	of	IN
cord-321401-w4ne60fn	346	12	the	the	DT
cord-321401-w4ne60fn	346	13	lung	lung	NN
cord-321401-w4ne60fn	346	14	in	in	IN
cord-321401-w4ne60fn	346	15	COPD	COPD	NNP
cord-321401-w4ne60fn	346	16	:	:	:
cord-321401-w4ne60fn	346	17	new	new	JJ
cord-321401-w4ne60fn	346	18	concepts	concept	NNS
cord-321401-w4ne60fn	347	1	Molecular	molecular	JJ
cord-321401-w4ne60fn	347	2	mechanisms	mechanism	NNS
cord-321401-w4ne60fn	347	3	of	of	IN
cord-321401-w4ne60fn	347	4	vitamin	vitamin	NN
cord-321401-w4ne60fn	347	5	D	d	NN
cord-321401-w4ne60fn	347	6	action	action	NN
cord-321401-w4ne60fn	347	7	Klotho	Klotho	NNP
cord-321401-w4ne60fn	347	8	:	:	:
cord-321401-w4ne60fn	347	9	an	an	DT
cord-321401-w4ne60fn	347	10	antiaging	antiaging	NN
cord-321401-w4ne60fn	347	11	protein	protein	NN
cord-321401-w4ne60fn	347	12	involved	involve	VBN
cord-321401-w4ne60fn	347	13	in	in	IN
cord-321401-w4ne60fn	347	14	mineral	mineral	NN
cord-321401-w4ne60fn	347	15	and	and	CC
cord-321401-w4ne60fn	347	16	vitamin	vitamin	NN
cord-321401-w4ne60fn	347	17	D	d	NN
cord-321401-w4ne60fn	347	18	metabolism	metabolism	NN
cord-321401-w4ne60fn	347	19	Fibroblast	Fibroblast	NNP
cord-321401-w4ne60fn	347	20	growth	growth	NN
cord-321401-w4ne60fn	347	21	factor	factor	NN
cord-321401-w4ne60fn	347	22	23	23	CD
cord-321401-w4ne60fn	348	1	and	and	CC
cord-321401-w4ne60fn	348	2	Klotho	Klotho	NNP
cord-321401-w4ne60fn	348	3	contribute	contribute	VB
cord-321401-w4ne60fn	348	4	to	to	IN
cord-321401-w4ne60fn	348	5	airway	airway	NN
cord-321401-w4ne60fn	348	6	inflammation	inflammation	NN
cord-321401-w4ne60fn	348	7	Klotho	Klotho	NNP
cord-321401-w4ne60fn	348	8	expression	expression	NN
cord-321401-w4ne60fn	349	1	is	be	VBZ
cord-321401-w4ne60fn	349	2	reduced	reduce	VBN
cord-321401-w4ne60fn	349	3	in	in	IN
cord-321401-w4ne60fn	349	4	COPD	COPD	NNP
cord-321401-w4ne60fn	349	5	airway	airway	NN
cord-321401-w4ne60fn	349	6	epithelial	epithelial	JJ
cord-321401-w4ne60fn	349	7	cells	cell	NNS
cord-321401-w4ne60fn	349	8	:	:	:
cord-321401-w4ne60fn	349	9	effects	effect	NNS
cord-321401-w4ne60fn	349	10	on	on	IN
cord-321401-w4ne60fn	349	11	inflammation	inflammation	NN
cord-321401-w4ne60fn	349	12	and	and	CC
cord-321401-w4ne60fn	349	13	oxidant	oxidant	JJ
cord-321401-w4ne60fn	349	14	injury	injury	NN
cord-321401-w4ne60fn	349	15	Critical	critical	JJ
cord-321401-w4ne60fn	349	16	roles	role	NNS
cord-321401-w4ne60fn	349	17	of	of	IN
cord-321401-w4ne60fn	349	18	intestinal	intestinal	JJ
cord-321401-w4ne60fn	349	19	epithelial	epithelial	JJ
cord-321401-w4ne60fn	349	20	vitamin	vitamin	NN
cord-321401-w4ne60fn	349	21	D	d	NN
cord-321401-w4ne60fn	349	22	receptor	receptor	NN
cord-321401-w4ne60fn	349	23	signaling	signal	VBG
cord-321401-w4ne60fn	349	24	in	in	IN
cord-321401-w4ne60fn	349	25	controlling	control	VBG
cord-321401-w4ne60fn	349	26	gut	gut	NN
cord-321401-w4ne60fn	349	27	mucosal	mucosal	JJ
cord-321401-w4ne60fn	349	28	inflammation	inflammation	NN
cord-321401-w4ne60fn	349	29	Imbalance	imbalance	NN
cord-321401-w4ne60fn	349	30	of	of	IN
cord-321401-w4ne60fn	349	31	autophagy	autophagy	NN
cord-321401-w4ne60fn	349	32	and	and	CC
cord-321401-w4ne60fn	349	33	apoptosis	apoptosis	NN
cord-321401-w4ne60fn	349	34	in	in	IN
cord-321401-w4ne60fn	349	35	intestinal	intestinal	JJ
cord-321401-w4ne60fn	349	36	epithelium	epithelium	NN
cord-321401-w4ne60fn	349	37	lacking	lack	VBG
cord-321401-w4ne60fn	349	38	the	the	DT
cord-321401-w4ne60fn	349	39	vitamin	vitamin	NN
cord-321401-w4ne60fn	349	40	D	d	NN
cord-321401-w4ne60fn	349	41	receptor	receptor	NN
cord-321401-w4ne60fn	349	42	Autophagy	Autophagy	NNP
cord-321401-w4ne60fn	349	43	and	and	CC
cord-321401-w4ne60fn	349	44	inflammation	inflammation	NN
cord-321401-w4ne60fn	349	45	in	in	IN
cord-321401-w4ne60fn	349	46	chronic	chronic	JJ
cord-321401-w4ne60fn	349	47	respiratory	respiratory	JJ
cord-321401-w4ne60fn	349	48	disease	disease	NN
cord-321401-w4ne60fn	350	1	Autophagy	Autophagy	NNP
cord-321401-w4ne60fn	350	2	proteins	protein	NNS
cord-321401-w4ne60fn	350	3	are	be	VBP
cord-321401-w4ne60fn	350	4	required	require	VBN
cord-321401-w4ne60fn	350	5	for	for	IN
cord-321401-w4ne60fn	350	6	club	club	NN
cord-321401-w4ne60fn	350	7	cell	cell	NN
cord-321401-w4ne60fn	350	8	structure	structure	NN
cord-321401-w4ne60fn	350	9	and	and	CC
cord-321401-w4ne60fn	350	10	function	function	NN
cord-321401-w4ne60fn	350	11	in	in	IN
cord-321401-w4ne60fn	350	12	airways	airway	NNS
cord-321401-w4ne60fn	350	13	Corticosteroid	Corticosteroid	NNP
cord-321401-w4ne60fn	350	14	resistance	resistance	NN
cord-321401-w4ne60fn	350	15	in	in	IN
cord-321401-w4ne60fn	350	16	patients	patient	NNS
cord-321401-w4ne60fn	350	17	with	with	IN
cord-321401-w4ne60fn	350	18	asthma	asthma	NN
cord-321401-w4ne60fn	350	19	and	and	CC
cord-321401-w4ne60fn	350	20	chronic	chronic	JJ
cord-321401-w4ne60fn	350	21	obstructive	obstructive	JJ
cord-321401-w4ne60fn	350	22	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	350	23	disease	disease	NN
cord-321401-w4ne60fn	350	24	Reversing	reverse	VBG
cord-321401-w4ne60fn	350	25	the	the	DT
cord-321401-w4ne60fn	350	26	defective	defective	JJ
cord-321401-w4ne60fn	350	27	induction	induction	NN
cord-321401-w4ne60fn	350	28	of	of	IN
cord-321401-w4ne60fn	350	29	IL-10-secreting	il-10-secrete	VBG
cord-321401-w4ne60fn	350	30	regulatory	regulatory	JJ
cord-321401-w4ne60fn	350	31	T	t	NN
cord-321401-w4ne60fn	350	32	cells	cell	NNS
cord-321401-w4ne60fn	350	33	in	in	IN
cord-321401-w4ne60fn	350	34	glucocorticoid	glucocorticoid	NN
cord-321401-w4ne60fn	350	35	-	-	HYPH
cord-321401-w4ne60fn	350	36	resistant	resistant	JJ
cord-321401-w4ne60fn	350	37	asthma	asthma	NN
cord-321401-w4ne60fn	350	38	patients	patient	NNS
cord-321401-w4ne60fn	350	39	Vitamin	vitamin	NN
cord-321401-w4ne60fn	350	40	D	d	NN
cord-321401-w4ne60fn	350	41	levels	level	NNS
cord-321401-w4ne60fn	350	42	,	,	,
cord-321401-w4ne60fn	350	43	lung	lung	NN
cord-321401-w4ne60fn	350	44	function	function	NN
cord-321401-w4ne60fn	350	45	,	,	,
cord-321401-w4ne60fn	350	46	and	and	CC
cord-321401-w4ne60fn	350	47	steroid	steroid	NN
cord-321401-w4ne60fn	350	48	response	response	NN
cord-321401-w4ne60fn	350	49	in	in	IN
cord-321401-w4ne60fn	350	50	adult	adult	NN
cord-321401-w4ne60fn	350	51	asthma	asthma	NN
cord-321401-w4ne60fn	350	52	25-Hydroxyvitamin	25-hydroxyvitamin	CD
cord-321401-w4ne60fn	350	53	D3-deficiency	d3-deficiency	NN
cord-321401-w4ne60fn	350	54	enhances	enhance	VBZ
cord-321401-w4ne60fn	350	55	oxidative	oxidative	JJ
cord-321401-w4ne60fn	350	56	stress	stress	NN
cord-321401-w4ne60fn	350	57	and	and	CC
cord-321401-w4ne60fn	350	58	corticosteroid	corticosteroid	NN
cord-321401-w4ne60fn	350	59	resistance	resistance	NN
cord-321401-w4ne60fn	350	60	in	in	IN
cord-321401-w4ne60fn	351	1	severe	severe	JJ
cord-321401-w4ne60fn	351	2	asthma	asthma	NN
cord-321401-w4ne60fn	351	3	exacerbation	exacerbation	NN
cord-321401-w4ne60fn	351	4	Vitamin	vitamin	NN
cord-321401-w4ne60fn	351	5	D	d	NN
cord-321401-w4ne60fn	351	6	downregulates	downregulate	VBZ
cord-321401-w4ne60fn	351	7	the	the	DT
cord-321401-w4ne60fn	351	8	IL-23	IL-23	NNP
cord-321401-w4ne60fn	351	9	receptor	receptor	NN
cord-321401-w4ne60fn	351	10	pathway	pathway	NN
cord-321401-w4ne60fn	351	11	in	in	IN
cord-321401-w4ne60fn	351	12	human	human	JJ
cord-321401-w4ne60fn	351	13	mucosal	mucosal	NN
cord-321401-w4ne60fn	351	14	group	group	NN
cord-321401-w4ne60fn	352	1	3	3	CD
cord-321401-w4ne60fn	352	2	innate	innate	JJ
cord-321401-w4ne60fn	352	3	lymphoid	lymphoid	JJ
cord-321401-w4ne60fn	352	4	cells	cell	NNS
cord-321401-w4ne60fn	352	5	Vitamin	vitamin	NN
cord-321401-w4ne60fn	352	6	D	d	NN
cord-321401-w4ne60fn	352	7	counteracts	counteract	VBZ
cord-321401-w4ne60fn	352	8	an	an	DT
cord-321401-w4ne60fn	352	9	IL-23-dependent	IL-23-dependent	NNP
cord-321401-w4ne60fn	352	10	IL-17A(+)IFN	il-17a(+)ifn	CD
cord-321401-w4ne60fn	352	11	-	-	HYPH
cord-321401-w4ne60fn	352	12	γ(+	γ(+	NN
cord-321401-w4ne60fn	352	13	)	)	-RRB-
cord-321401-w4ne60fn	352	14	response	response	NN
cord-321401-w4ne60fn	352	15	driven	drive	VBN
cord-321401-w4ne60fn	352	16	by	by	IN
cord-321401-w4ne60fn	352	17	urban	urban	JJ
cord-321401-w4ne60fn	352	18	particulate	particulate	NN
cord-321401-w4ne60fn	352	19	matter	matter	NN
cord-321401-w4ne60fn	352	20	Comparative	comparative	JJ
cord-321401-w4ne60fn	352	21	effect	effect	NN
cord-321401-w4ne60fn	352	22	of	of	IN
cord-321401-w4ne60fn	352	23	25(OH)D3	25(oh)d3	CD
cord-321401-w4ne60fn	352	24	and	and	CC
cord-321401-w4ne60fn	352	25	1,25(OH)2D3	1,25(oh)2d3	CD
cord-321401-w4ne60fn	352	26	on	on	IN
cord-321401-w4ne60fn	353	1	Th17	Th17	NNP
cord-321401-w4ne60fn	354	1	cell	cell	NN
cord-321401-w4ne60fn	354	2	differentiation	differentiation	NN
cord-321401-w4ne60fn	355	1	Enhanced	enhanced	JJ
cord-321401-w4ne60fn	355	2	production	production	NN
cord-321401-w4ne60fn	355	3	of	of	IN
cord-321401-w4ne60fn	355	4	IL-17A	il-17a	NN
cord-321401-w4ne60fn	355	5	in	in	IN
cord-321401-w4ne60fn	355	6	patients	patient	NNS
cord-321401-w4ne60fn	355	7	with	with	IN
cord-321401-w4ne60fn	355	8	severe	severe	JJ
cord-321401-w4ne60fn	355	9	asthma	asthma	NN
cord-321401-w4ne60fn	355	10	is	be	VBZ
cord-321401-w4ne60fn	355	11	inhibited	inhibit	VBN
cord-321401-w4ne60fn	355	12	by	by	IN
cord-321401-w4ne60fn	355	13	1α,25-dihydroxyvitamin	1α,25-dihydroxyvitamin	CD
cord-321401-w4ne60fn	355	14	D3	D3	NNP
cord-321401-w4ne60fn	355	15	in	in	IN
cord-321401-w4ne60fn	355	16	a	a	DT
cord-321401-w4ne60fn	355	17	glucocorticoidindependent	glucocorticoidindependent	JJ
cord-321401-w4ne60fn	355	18	fashion	fashion	NN
cord-321401-w4ne60fn	355	19	Novel	novel	NN
cord-321401-w4ne60fn	355	20	regulation	regulation	NN
cord-321401-w4ne60fn	355	21	of	of	IN
cord-321401-w4ne60fn	355	22	25-hydroxyvitamin	25-hydroxyvitamin	CD
cord-321401-w4ne60fn	355	23	D3	D3	NNP
cord-321401-w4ne60fn	355	24	24-hydroxylase	24-hydroxylase	CD
cord-321401-w4ne60fn	355	25	(	(	-LRB-
cord-321401-w4ne60fn	355	26	24(OH)ase	24(oh)ase	CD
cord-321401-w4ne60fn	355	27	)	)	-RRB-
cord-321401-w4ne60fn	355	28	transcription	transcription	NN
cord-321401-w4ne60fn	355	29	by	by	IN
cord-321401-w4ne60fn	355	30	glucocorticoids	glucocorticoid	NNS
cord-321401-w4ne60fn	355	31	:	:	:
cord-321401-w4ne60fn	355	32	cooperative	cooperative	JJ
cord-321401-w4ne60fn	355	33	effects	effect	NNS
cord-321401-w4ne60fn	355	34	of	of	IN
cord-321401-w4ne60fn	355	35	the	the	DT
cord-321401-w4ne60fn	355	36	glucocorticoid	glucocorticoid	NN
cord-321401-w4ne60fn	355	37	receptor	receptor	NN
cord-321401-w4ne60fn	355	38	,	,	,
cord-321401-w4ne60fn	355	39	C	C	NNP
cord-321401-w4ne60fn	355	40	/	/	SYM
cord-321401-w4ne60fn	355	41	EBPβ	EBPβ	NNS
cord-321401-w4ne60fn	355	42	,	,	,
cord-321401-w4ne60fn	355	43	and	and	CC
cord-321401-w4ne60fn	355	44	the	the	DT
cord-321401-w4ne60fn	355	45	Vitamin	vitamin	NN
cord-321401-w4ne60fn	355	46	D	d	NN
cord-321401-w4ne60fn	355	47	receptor	receptor	NN
cord-321401-w4ne60fn	355	48	in	in	IN
cord-321401-w4ne60fn	355	49	24(OH)ase	24(oh)ase	CD
cord-321401-w4ne60fn	355	50	transcription	transcription	NN
cord-321401-w4ne60fn	355	51	Relationship	relationship	NN
cord-321401-w4ne60fn	355	52	between	between	IN
cord-321401-w4ne60fn	355	53	exacerbation	exacerbation	NN
cord-321401-w4ne60fn	355	54	frequency	frequency	NN
cord-321401-w4ne60fn	355	55	and	and	CC
cord-321401-w4ne60fn	355	56	lung	lung	NN
cord-321401-w4ne60fn	355	57	function	function	NN
cord-321401-w4ne60fn	355	58	decline	decline	NN
cord-321401-w4ne60fn	355	59	in	in	IN
cord-321401-w4ne60fn	355	60	chronic	chronic	JJ
cord-321401-w4ne60fn	355	61	obstructive	obstructive	JJ
cord-321401-w4ne60fn	355	62	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	355	63	disease	disease	NN
cord-321401-w4ne60fn	355	64	Chronic	Chronic	NNP
cord-321401-w4ne60fn	355	65	obstructive	obstructive	JJ
cord-321401-w4ne60fn	355	66	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	355	67	disease	disease	NN
cord-321401-w4ne60fn	356	1	The	the	DT
cord-321401-w4ne60fn	356	2	role	role	NN
cord-321401-w4ne60fn	356	3	of	of	IN
cord-321401-w4ne60fn	356	4	acute	acute	JJ
cord-321401-w4ne60fn	356	5	and	and	CC
cord-321401-w4ne60fn	356	6	chronic	chronic	JJ
cord-321401-w4ne60fn	356	7	respiratory	respiratory	JJ
cord-321401-w4ne60fn	356	8	colonization	colonization	NN
cord-321401-w4ne60fn	356	9	and	and	CC
cord-321401-w4ne60fn	356	10	infections	infection	NNS
cord-321401-w4ne60fn	356	11	in	in	IN
cord-321401-w4ne60fn	356	12	the	the	DT
cord-321401-w4ne60fn	356	13	pathogenesis	pathogenesis	NN
cord-321401-w4ne60fn	356	14	of	of	IN
cord-321401-w4ne60fn	356	15	COPD	COPD	NNP
cord-321401-w4ne60fn	356	16	Lung	Lung	NNP
cord-321401-w4ne60fn	356	17	microbiome	microbiome	NN
cord-321401-w4ne60fn	356	18	dynamics	dynamic	NNS
cord-321401-w4ne60fn	356	19	in	in	IN
cord-321401-w4ne60fn	356	20	COPD	COPD	NNP
cord-321401-w4ne60fn	356	21	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	357	1	Vitamin	vitamin	NN
cord-321401-w4ne60fn	357	2	D	d	NN
cord-321401-w4ne60fn	357	3	supplementation	supplementation	NN
cord-321401-w4ne60fn	357	4	attenuates	attenuate	VBZ
cord-321401-w4ne60fn	357	5	asthma	asthma	NN
cord-321401-w4ne60fn	357	6	development	development	NN
cord-321401-w4ne60fn	357	7	following	follow	VBG
cord-321401-w4ne60fn	357	8	traffic	traffic	NN
cord-321401-w4ne60fn	357	9	-	-	HYPH
cord-321401-w4ne60fn	357	10	related	relate	VBN
cord-321401-w4ne60fn	357	11	particulate	particulate	NN
cord-321401-w4ne60fn	357	12	matter	matter	NN
cord-321401-w4ne60fn	357	13	exposure	exposure	NN
cord-321401-w4ne60fn	357	14	Resolving	resolve	VBG
cord-321401-w4ne60fn	357	15	viralinduced	viralinduce	VBN
cord-321401-w4ne60fn	357	16	secondary	secondary	JJ
cord-321401-w4ne60fn	357	17	bacterial	bacterial	JJ
cord-321401-w4ne60fn	357	18	infection	infection	NN
cord-321401-w4ne60fn	357	19	in	in	IN
cord-321401-w4ne60fn	357	20	COPD	COPD	NNP
cord-321401-w4ne60fn	357	21	:	:	:
cord-321401-w4ne60fn	357	22	a	a	DT
cord-321401-w4ne60fn	357	23	concise	concise	JJ
cord-321401-w4ne60fn	357	24	review	review	NN
cord-321401-w4ne60fn	357	25	Time	time	NN
cord-321401-w4ne60fn	357	26	-	-	HYPH
cord-321401-w4ne60fn	357	27	course	course	NN
cord-321401-w4ne60fn	357	28	of	of	IN
cord-321401-w4ne60fn	357	29	upper	upper	JJ
cord-321401-w4ne60fn	357	30	respiratory	respiratory	JJ
cord-321401-w4ne60fn	357	31	tract	tract	NN
cord-321401-w4ne60fn	357	32	viral	viral	JJ
cord-321401-w4ne60fn	357	33	infection	infection	NN
cord-321401-w4ne60fn	357	34	and	and	CC
cord-321401-w4ne60fn	357	35	COPD	COPD	NNP
cord-321401-w4ne60fn	357	36	exacerbation	exacerbation	NN
cord-321401-w4ne60fn	357	37	Vitamin	vitamin	NN
cord-321401-w4ne60fn	357	38	D	d	NN
cord-321401-w4ne60fn	357	39	represses	repress	VBZ
cord-321401-w4ne60fn	357	40	rhinovirus	rhinovirus	NN
cord-321401-w4ne60fn	357	41	replication	replication	NN
cord-321401-w4ne60fn	357	42	in	in	IN
cord-321401-w4ne60fn	357	43	cystic	cystic	JJ
cord-321401-w4ne60fn	357	44	fibrosis	fibrosis	NN
cord-321401-w4ne60fn	357	45	cells	cell	NNS
cord-321401-w4ne60fn	357	46	by	by	IN
cord-321401-w4ne60fn	357	47	inducing	induce	VBG
cord-321401-w4ne60fn	357	48	LL-37	LL-37	NNP
cord-321401-w4ne60fn	357	49	Cathelicidins	Cathelicidins	NNP
cord-321401-w4ne60fn	357	50	display	display	NN
cord-321401-w4ne60fn	357	51	conserved	conserve	VBN
cord-321401-w4ne60fn	357	52	direct	direct	JJ
cord-321401-w4ne60fn	357	53	antiviral	antiviral	JJ
cord-321401-w4ne60fn	357	54	activity	activity	NN
cord-321401-w4ne60fn	357	55	towards	towards	IN
cord-321401-w4ne60fn	357	56	rhinovirus	rhinovirus	NN
cord-321401-w4ne60fn	357	57	Effects	effect	NNS
cord-321401-w4ne60fn	357	58	of	of	IN
cord-321401-w4ne60fn	357	59	vitamin	vitamin	NN
cord-321401-w4ne60fn	357	60	D	d	NN
cord-321401-w4ne60fn	357	61	on	on	IN
cord-321401-w4ne60fn	357	62	airway	airway	JJ
cord-321401-w4ne60fn	357	63	epithelial	epithelial	JJ
cord-321401-w4ne60fn	357	64	cell	cell	NN
cord-321401-w4ne60fn	357	65	morphology	morphology	NN
cord-321401-w4ne60fn	357	66	and	and	CC
cord-321401-w4ne60fn	357	67	rhinovirus	rhinovirus	NN
cord-321401-w4ne60fn	357	68	replication	replication	NN
cord-321401-w4ne60fn	357	69	Effects	effect	NNS
cord-321401-w4ne60fn	357	70	of	of	IN
cord-321401-w4ne60fn	357	71	calcitriol	calcitriol	NN
cord-321401-w4ne60fn	357	72	(	(	-LRB-
cord-321401-w4ne60fn	357	73	1	1	CD
cord-321401-w4ne60fn	357	74	,	,	,
cord-321401-w4ne60fn	357	75	25-dihydroxyvitamin	25-dihydroxyvitamin	CD
cord-321401-w4ne60fn	357	76	D3	D3	NNP
cord-321401-w4ne60fn	357	77	)	)	-RRB-
cord-321401-w4ne60fn	357	78	on	on	IN
cord-321401-w4ne60fn	357	79	the	the	DT
cord-321401-w4ne60fn	357	80	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	357	81	response	response	NN
cord-321401-w4ne60fn	357	82	induced	induce	VBN
cord-321401-w4ne60fn	357	83	by	by	IN
cord-321401-w4ne60fn	357	84	H9N2	H9N2	NNP
cord-321401-w4ne60fn	357	85	influenza	influenza	NN
cord-321401-w4ne60fn	357	86	virus	virus	NN
cord-321401-w4ne60fn	357	87	infection	infection	NN
cord-321401-w4ne60fn	357	88	in	in	IN
cord-321401-w4ne60fn	357	89	human	human	JJ
cord-321401-w4ne60fn	357	90	lung	lung	NN
cord-321401-w4ne60fn	357	91	A549	a549	CD
cord-321401-w4ne60fn	357	92	epithelial	epithelial	JJ
cord-321401-w4ne60fn	357	93	cells	cell	NNS
cord-321401-w4ne60fn	357	94	and	and	CC
cord-321401-w4ne60fn	357	95	in	in	IN
cord-321401-w4ne60fn	357	96	mice	mouse	NNS
cord-321401-w4ne60fn	357	97	Calcitriol	Calcitriol	NNP
cord-321401-w4ne60fn	358	1	[	[	-LRB-
cord-321401-w4ne60fn	358	2	1	1	CD
cord-321401-w4ne60fn	358	3	,	,	,
cord-321401-w4ne60fn	358	4	25[OH]2	25[OH]2	NNP
cord-321401-w4ne60fn	358	5	D3	D3	NNP
cord-321401-w4ne60fn	358	6	]	]	-RRB-
cord-321401-w4ne60fn	358	7	pre	pre	JJ
cord-321401-w4ne60fn	358	8	-	-	JJ
cord-321401-w4ne60fn	358	9	and	and	CC
cord-321401-w4ne60fn	358	10	post	post	JJ
cord-321401-w4ne60fn	358	11	-	-	NN
cord-321401-w4ne60fn	358	12	treatment	treatment	NN
cord-321401-w4ne60fn	358	13	suppresses	suppress	VBZ
cord-321401-w4ne60fn	358	14	inflammatory	inflammatory	JJ
cord-321401-w4ne60fn	358	15	response	response	NN
cord-321401-w4ne60fn	358	16	to	to	TO
cord-321401-w4ne60fn	358	17	influenza	influenza	VB
cord-321401-w4ne60fn	358	18	A	a	DT
cord-321401-w4ne60fn	358	19	(	(	-LRB-
cord-321401-w4ne60fn	358	20	H1N1	H1N1	NNP
cord-321401-w4ne60fn	358	21	)	)	-RRB-
cord-321401-w4ne60fn	358	22	infection	infection	NN
cord-321401-w4ne60fn	358	23	in	in	IN
cord-321401-w4ne60fn	358	24	human	human	JJ
cord-321401-w4ne60fn	358	25	lung	lung	NN
cord-321401-w4ne60fn	358	26	A549	a549	IN
cord-321401-w4ne60fn	358	27	epithelial	epithelial	JJ
cord-321401-w4ne60fn	358	28	cells	cell	NNS
cord-321401-w4ne60fn	358	29	Infection	infection	NN
cord-321401-w4ne60fn	358	30	in	in	IN
cord-321401-w4ne60fn	358	31	the	the	DT
cord-321401-w4ne60fn	358	32	pathogenesis	pathogenesis	NN
cord-321401-w4ne60fn	358	33	and	and	CC
cord-321401-w4ne60fn	358	34	course	course	NN
cord-321401-w4ne60fn	358	35	of	of	IN
cord-321401-w4ne60fn	358	36	chronic	chronic	JJ
cord-321401-w4ne60fn	358	37	obstructive	obstructive	JJ
cord-321401-w4ne60fn	358	38	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	358	39	disease	disease	NN
cord-321401-w4ne60fn	358	40	New	new	JJ
cord-321401-w4ne60fn	358	41	strains	strain	NNS
cord-321401-w4ne60fn	358	42	of	of	IN
cord-321401-w4ne60fn	358	43	bacteria	bacteria	NNS
cord-321401-w4ne60fn	358	44	and	and	CC
cord-321401-w4ne60fn	358	45	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	358	46	of	of	IN
cord-321401-w4ne60fn	358	47	chronic	chronic	JJ
cord-321401-w4ne60fn	358	48	obstructive	obstructive	JJ
cord-321401-w4ne60fn	358	49	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	358	50	disease	disease	NN
cord-321401-w4ne60fn	359	1	A	a	DT
cord-321401-w4ne60fn	359	2	prospective	prospective	JJ
cord-321401-w4ne60fn	359	3	,	,	,
cord-321401-w4ne60fn	359	4	observational	observational	JJ
cord-321401-w4ne60fn	359	5	cohort	cohort	NN
cord-321401-w4ne60fn	359	6	study	study	NN
cord-321401-w4ne60fn	359	7	of	of	IN
cord-321401-w4ne60fn	359	8	the	the	DT
cord-321401-w4ne60fn	359	9	seasonal	seasonal	JJ
cord-321401-w4ne60fn	359	10	dynamics	dynamic	NNS
cord-321401-w4ne60fn	359	11	of	of	IN
cord-321401-w4ne60fn	359	12	airway	airway	NN
cord-321401-w4ne60fn	359	13	pathogens	pathogen	NNS
cord-321401-w4ne60fn	359	14	in	in	IN
cord-321401-w4ne60fn	359	15	the	the	DT
cord-321401-w4ne60fn	359	16	aetiology	aetiology	NN
cord-321401-w4ne60fn	359	17	of	of	IN
cord-321401-w4ne60fn	359	18	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	359	19	in	in	IN
cord-321401-w4ne60fn	359	20	COPD	COPD	NNP
cord-321401-w4ne60fn	359	21	Induction	Induction	NNP
cord-321401-w4ne60fn	359	22	of	of	IN
cord-321401-w4ne60fn	359	23	cathelicidin	cathelicidin	NNP
cord-321401-w4ne60fn	359	24	in	in	IN
cord-321401-w4ne60fn	359	25	normal	normal	JJ
cord-321401-w4ne60fn	359	26	and	and	CC
cord-321401-w4ne60fn	359	27	CF	cf	NN
cord-321401-w4ne60fn	359	28	bronchial	bronchial	JJ
cord-321401-w4ne60fn	359	29	epithelial	epithelial	JJ
cord-321401-w4ne60fn	359	30	cells	cell	NNS
cord-321401-w4ne60fn	359	31	by	by	IN
cord-321401-w4ne60fn	359	32	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	CD
cord-321401-w4ne60fn	359	33	D(3	d(3	CD
cord-321401-w4ne60fn	359	34	)	)	-RRB-
cord-321401-w4ne60fn	360	1	Species	species	NN
cord-321401-w4ne60fn	360	2	-	-	HYPH
cord-321401-w4ne60fn	360	3	specific	specific	JJ
cord-321401-w4ne60fn	360	4	regulation	regulation	NN
cord-321401-w4ne60fn	360	5	of	of	IN
cord-321401-w4ne60fn	360	6	innate	innate	JJ
cord-321401-w4ne60fn	360	7	immunity	immunity	NN
cord-321401-w4ne60fn	360	8	by	by	IN
cord-321401-w4ne60fn	360	9	vitamin	vitamin	NN
cord-321401-w4ne60fn	360	10	D	d	NN
cord-321401-w4ne60fn	360	11	signaling	signal	VBG
cord-321401-w4ne60fn	361	1	Human	human	JJ
cord-321401-w4ne60fn	361	2	cathelicidin	cathelicidin	NN
cord-321401-w4ne60fn	361	3	antimicrobial	antimicrobial	NN
cord-321401-w4ne60fn	361	4	peptide	peptide	NN
cord-321401-w4ne60fn	361	5	(	(	-LRB-
cord-321401-w4ne60fn	361	6	CAMP	camp	NN
cord-321401-w4ne60fn	361	7	)	)	-RRB-
cord-321401-w4ne60fn	361	8	gene	gene	NN
cord-321401-w4ne60fn	361	9	is	be	VBZ
cord-321401-w4ne60fn	361	10	a	a	DT
cord-321401-w4ne60fn	361	11	direct	direct	JJ
cord-321401-w4ne60fn	361	12	target	target	NN
cord-321401-w4ne60fn	361	13	of	of	IN
cord-321401-w4ne60fn	361	14	the	the	DT
cord-321401-w4ne60fn	361	15	vitamin	vitamin	NN
cord-321401-w4ne60fn	361	16	D	d	NN
cord-321401-w4ne60fn	361	17	receptor	receptor	NN
cord-321401-w4ne60fn	361	18	and	and	CC
cord-321401-w4ne60fn	361	19	is	be	VBZ
cord-321401-w4ne60fn	361	20	strongly	strongly	RB
cord-321401-w4ne60fn	361	21	up	up	RB
cord-321401-w4ne60fn	361	22	-	-	HYPH
cord-321401-w4ne60fn	361	23	regulated	regulate	VBN
cord-321401-w4ne60fn	361	24	in	in	IN
cord-321401-w4ne60fn	361	25	myeloid	myeloid	JJ
cord-321401-w4ne60fn	361	26	cells	cell	NNS
cord-321401-w4ne60fn	361	27	by	by	IN
cord-321401-w4ne60fn	361	28	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	CD
cord-321401-w4ne60fn	361	29	D3	D3	NNP
cord-321401-w4ne60fn	361	30	Vitamin	vitamin	NN
cord-321401-w4ne60fn	361	31	D	d	NN
cord-321401-w4ne60fn	361	32	deficiency	deficiency	NN
cord-321401-w4ne60fn	361	33	does	do	VBZ
cord-321401-w4ne60fn	361	34	not	not	RB
cord-321401-w4ne60fn	361	35	result	result	VB
cord-321401-w4ne60fn	361	36	in	in	IN
cord-321401-w4ne60fn	361	37	a	a	DT
cord-321401-w4ne60fn	361	38	breach	breach	NN
cord-321401-w4ne60fn	361	39	of	of	IN
cord-321401-w4ne60fn	361	40	host	host	NN
cord-321401-w4ne60fn	361	41	defense	defense	NN
cord-321401-w4ne60fn	361	42	in	in	IN
cord-321401-w4ne60fn	361	43	murine	murine	JJ
cord-321401-w4ne60fn	361	44	models	model	NNS
cord-321401-w4ne60fn	361	45	of	of	IN
cord-321401-w4ne60fn	361	46	pneumonia	pneumonia	NN
cord-321401-w4ne60fn	361	47	A	a	DT
cord-321401-w4ne60fn	361	48	mouse	mouse	NN
cord-321401-w4ne60fn	361	49	model	model	NN
cord-321401-w4ne60fn	361	50	for	for	IN
cord-321401-w4ne60fn	361	51	vitamin	vitamin	NN
cord-321401-w4ne60fn	361	52	D	d	NN
cord-321401-w4ne60fn	361	53	-	-	HYPH
cord-321401-w4ne60fn	361	54	induced	induce	VBN
cord-321401-w4ne60fn	361	55	human	human	JJ
cord-321401-w4ne60fn	361	56	cathelicidin	cathelicidin	NNP
cord-321401-w4ne60fn	361	57	antimicrobial	antimicrobial	JJ
cord-321401-w4ne60fn	361	58	peptide	peptide	NN
cord-321401-w4ne60fn	361	59	gene	gene	NN
cord-321401-w4ne60fn	361	60	expression	expression	NN
cord-321401-w4ne60fn	361	61	Ontogeny	ontogeny	NN
cord-321401-w4ne60fn	361	62	and	and	CC
cord-321401-w4ne60fn	361	63	biology	biology	NN
cord-321401-w4ne60fn	361	64	of	of	IN
cord-321401-w4ne60fn	361	65	human	human	JJ
cord-321401-w4ne60fn	361	66	small	small	JJ
cord-321401-w4ne60fn	361	67	airway	airway	NN
cord-321401-w4ne60fn	361	68	epithelial	epithelial	JJ
cord-321401-w4ne60fn	361	69	club	club	NN
cord-321401-w4ne60fn	361	70	cells	cell	NNS
cord-321401-w4ne60fn	361	71	Role	role	NN
cord-321401-w4ne60fn	361	72	of	of	IN
cord-321401-w4ne60fn	361	73	vitamin	vitamin	NN
cord-321401-w4ne60fn	361	74	D	d	NN
cord-321401-w4ne60fn	361	75	in	in	IN
cord-321401-w4ne60fn	361	76	the	the	DT
cord-321401-w4ne60fn	361	77	hygiene	hygiene	NN
cord-321401-w4ne60fn	361	78	hypothesis	hypothesis	NN
cord-321401-w4ne60fn	361	79	:	:	:
cord-321401-w4ne60fn	362	1	the	the	DT
cord-321401-w4ne60fn	362	2	interplay	interplay	NN
cord-321401-w4ne60fn	362	3	between	between	IN
cord-321401-w4ne60fn	362	4	vitamin	vitamin	NN
cord-321401-w4ne60fn	362	5	d	d	NN
cord-321401-w4ne60fn	362	6	,	,	,
cord-321401-w4ne60fn	362	7	vitamin	vitamin	NN
cord-321401-w4ne60fn	362	8	d	d	NN
cord-321401-w4ne60fn	362	9	receptors	receptor	NNS
cord-321401-w4ne60fn	362	10	,	,	,
cord-321401-w4ne60fn	362	11	gut	gut	VB
cord-321401-w4ne60fn	362	12	microbiota	microbiota	NN
cord-321401-w4ne60fn	362	13	,	,	,
cord-321401-w4ne60fn	362	14	immune	immune	JJ
cord-321401-w4ne60fn	362	15	response	response	NN
cord-321401-w4ne60fn	362	16	Paneth	Paneth	NNP
cord-321401-w4ne60fn	362	17	cell	cell	NN
cord-321401-w4ne60fn	362	18	defensins	defensin	NNS
cord-321401-w4ne60fn	362	19	and	and	CC
cord-321401-w4ne60fn	362	20	the	the	DT
cord-321401-w4ne60fn	362	21	regulation	regulation	NN
cord-321401-w4ne60fn	362	22	of	of	IN
cord-321401-w4ne60fn	362	23	the	the	DT
cord-321401-w4ne60fn	362	24	microbiome	microbiome	NN
cord-321401-w4ne60fn	362	25	:	:	:
cord-321401-w4ne60fn	362	26	détente	détente	NN
cord-321401-w4ne60fn	362	27	at	at	IN
cord-321401-w4ne60fn	362	28	mucosal	mucosal	JJ
cord-321401-w4ne60fn	362	29	surfaces	surface	NNS
cord-321401-w4ne60fn	362	30	Gut	gut	VBP
cord-321401-w4ne60fn	362	31	microbiota	microbiota	NN
cord-321401-w4ne60fn	362	32	.	.	.
cord-321401-w4ne60fn	363	1	Antimicrobial	antimicrobial	JJ
cord-321401-w4ne60fn	363	2	peptide	peptide	NN
cord-321401-w4ne60fn	363	3	resistance	resistance	NN
cord-321401-w4ne60fn	363	4	mediates	mediate	VBZ
cord-321401-w4ne60fn	363	5	resilience	resilience	NN
cord-321401-w4ne60fn	363	6	of	of	IN
cord-321401-w4ne60fn	363	7	prominent	prominent	JJ
cord-321401-w4ne60fn	363	8	gut	gut	NN
cord-321401-w4ne60fn	363	9	commensals	commensal	NNS
cord-321401-w4ne60fn	363	10	during	during	IN
cord-321401-w4ne60fn	363	11	inflammation	inflammation	NN
cord-321401-w4ne60fn	363	12	Emerging	emerge	VBG
cord-321401-w4ne60fn	363	13	pathogenic	pathogenic	JJ
cord-321401-w4ne60fn	363	14	links	link	NNS
cord-321401-w4ne60fn	363	15	between	between	IN
cord-321401-w4ne60fn	363	16	microbiota	microbiota	NN
cord-321401-w4ne60fn	363	17	and	and	CC
cord-321401-w4ne60fn	363	18	the	the	DT
cord-321401-w4ne60fn	363	19	gut	gut	NN
cord-321401-w4ne60fn	363	20	-	-	HYPH
cord-321401-w4ne60fn	363	21	lung	lung	NN
cord-321401-w4ne60fn	363	22	axis	axis	NN
cord-321401-w4ne60fn	363	23	Microbes	microbe	NNS
cord-321401-w4ne60fn	363	24	,	,	,
cord-321401-w4ne60fn	363	25	metabolites	metabolite	NNS
cord-321401-w4ne60fn	363	26	,	,	,
cord-321401-w4ne60fn	363	27	and	and	CC
cord-321401-w4ne60fn	363	28	the	the	DT
cord-321401-w4ne60fn	363	29	gut	gut	NN
cord-321401-w4ne60fn	363	30	-	-	HYPH
cord-321401-w4ne60fn	363	31	lung	lung	NN
cord-321401-w4ne60fn	363	32	axis	axis	NN
cord-321401-w4ne60fn	363	33	Vitamin	vitamin	NN
cord-321401-w4ne60fn	363	34	D	d	NN
cord-321401-w4ne60fn	363	35	and	and	CC
cord-321401-w4ne60fn	363	36	the	the	DT
cord-321401-w4ne60fn	363	37	gut	gut	NN
cord-321401-w4ne60fn	363	38	microbiome	microbiome	NN
cord-321401-w4ne60fn	363	39	:	:	:
cord-321401-w4ne60fn	363	40	a	a	DT
cord-321401-w4ne60fn	363	41	systematic	systematic	JJ
cord-321401-w4ne60fn	363	42	review	review	NN
cord-321401-w4ne60fn	363	43	of	of	IN
cord-321401-w4ne60fn	363	44	in	in	IN
cord-321401-w4ne60fn	363	45	vivo	vivo	NN
cord-321401-w4ne60fn	363	46	studies	study	NNS
cord-321401-w4ne60fn	363	47	Influence	influence	NN
cord-321401-w4ne60fn	363	48	of	of	IN
cord-321401-w4ne60fn	363	49	vitamin	vitamin	NN
cord-321401-w4ne60fn	363	50	D	d	NN
cord-321401-w4ne60fn	363	51	on	on	IN
cord-321401-w4ne60fn	363	52	key	key	JJ
cord-321401-w4ne60fn	363	53	bacterial	bacterial	JJ
cord-321401-w4ne60fn	363	54	taxa	taxon	NNS
cord-321401-w4ne60fn	363	55	in	in	IN
cord-321401-w4ne60fn	363	56	infant	infant	NN
cord-321401-w4ne60fn	363	57	microbiota	microbiota	NN
cord-321401-w4ne60fn	363	58	in	in	IN
cord-321401-w4ne60fn	363	59	the	the	DT
cord-321401-w4ne60fn	363	60	KOALA	KOALA	NNP
cord-321401-w4ne60fn	363	61	birth	birth	NN
cord-321401-w4ne60fn	363	62	cohort	cohort	NN
cord-321401-w4ne60fn	363	63	study	study	NN
cord-321401-w4ne60fn	363	64	Vitamin	Vitamin	NNP
cord-321401-w4ne60fn	363	65	D	D	NNP
cord-321401-w4ne60fn	363	66	administration	administration	NN
cord-321401-w4ne60fn	363	67	leads	lead	VBZ
cord-321401-w4ne60fn	363	68	to	to	IN
cord-321401-w4ne60fn	363	69	a	a	DT
cord-321401-w4ne60fn	363	70	shift	shift	NN
cord-321401-w4ne60fn	363	71	of	of	IN
cord-321401-w4ne60fn	363	72	the	the	DT
cord-321401-w4ne60fn	363	73	intestinal	intestinal	JJ
cord-321401-w4ne60fn	363	74	bacterial	bacterial	JJ
cord-321401-w4ne60fn	363	75	composition	composition	NN
cord-321401-w4ne60fn	363	76	in	in	IN
cord-321401-w4ne60fn	363	77	crohn	crohn	NNP
cord-321401-w4ne60fn	363	78	's	's	POS
cord-321401-w4ne60fn	363	79	disease	disease	NN
cord-321401-w4ne60fn	363	80	patients	patient	NNS
cord-321401-w4ne60fn	363	81	,	,	,
cord-321401-w4ne60fn	363	82	but	but	CC
cord-321401-w4ne60fn	363	83	not	not	RB
cord-321401-w4ne60fn	363	84	in	in	IN
cord-321401-w4ne60fn	363	85	healthy	healthy	JJ
cord-321401-w4ne60fn	363	86	controls	control	NNS
cord-321401-w4ne60fn	364	1	The	the	DT
cord-321401-w4ne60fn	364	2	microbiome	microbiome	NN
cord-321401-w4ne60fn	364	3	and	and	CC
cord-321401-w4ne60fn	364	4	the	the	DT
cord-321401-w4ne60fn	364	5	pathophysiology	pathophysiology	NN
cord-321401-w4ne60fn	364	6	of	of	IN
cord-321401-w4ne60fn	364	7	asthma	asthma	NN
cord-321401-w4ne60fn	364	8	'	'	POS
cord-321401-w4ne60fn	364	9	circulating	circulate	VBG
cord-321401-w4ne60fn	364	10	25-hydroxyvitamin	25-hydroxyvitamin	CD
cord-321401-w4ne60fn	364	11	D	d	NN
cord-321401-w4ne60fn	364	12	,	,	,
cord-321401-w4ne60fn	364	13	nasopharyngeal	nasopharyngeal	JJ
cord-321401-w4ne60fn	364	14	microbiota	microbiota	NN
cord-321401-w4ne60fn	364	15	,	,	,
cord-321401-w4ne60fn	364	16	bronchiolitis	bronchiolitis	NN
cord-321401-w4ne60fn	364	17	severity	severity	NN
cord-321401-w4ne60fn	364	18	Bolus	Bolus	NNP
cord-321401-w4ne60fn	364	19	weekly	weekly	JJ
cord-321401-w4ne60fn	364	20	vitamin	vitamin	NN
cord-321401-w4ne60fn	364	21	D3	D3	NNP
cord-321401-w4ne60fn	364	22	supplementation	supplementation	NN
cord-321401-w4ne60fn	364	23	impacts	impact	VBZ
cord-321401-w4ne60fn	364	24	gut	gut	NN
cord-321401-w4ne60fn	364	25	and	and	CC
cord-321401-w4ne60fn	364	26	airway	airway	NN
cord-321401-w4ne60fn	364	27	microbiota	microbiota	NN
cord-321401-w4ne60fn	364	28	in	in	IN
cord-321401-w4ne60fn	364	29	adults	adult	NNS
cord-321401-w4ne60fn	364	30	with	with	IN
cord-321401-w4ne60fn	364	31	cystic	cystic	JJ
cord-321401-w4ne60fn	364	32	fibrosis	fibrosis	NN
cord-321401-w4ne60fn	364	33	:	:	:
cord-321401-w4ne60fn	364	34	a	a	DT
cord-321401-w4ne60fn	364	35	double	double	JJ
cord-321401-w4ne60fn	364	36	-	-	HYPH
cord-321401-w4ne60fn	364	37	blind	blind	JJ
cord-321401-w4ne60fn	364	38	,	,	,
cord-321401-w4ne60fn	364	39	randomized	randomized	JJ
cord-321401-w4ne60fn	364	40	,	,	,
cord-321401-w4ne60fn	364	41	placebo	placebo	NN
cord-321401-w4ne60fn	364	42	-	-	HYPH
cord-321401-w4ne60fn	364	43	controlled	control	VBN
cord-321401-w4ne60fn	364	44	clinical	clinical	JJ
cord-321401-w4ne60fn	364	45	trial	trial	NN
cord-321401-w4ne60fn	364	46	Effects	effect	NNS
cord-321401-w4ne60fn	364	47	of	of	IN
cord-321401-w4ne60fn	364	48	vitamin	vitamin	NN
cord-321401-w4ne60fn	364	49	D	D	NNP
cord-321401-w4ne60fn	364	50	Intake	Intake	NNP
cord-321401-w4ne60fn	364	51	on	on	IN
cord-321401-w4ne60fn	364	52	FEV1	FEV1	NNP
cord-321401-w4ne60fn	364	53	and	and	CC
cord-321401-w4ne60fn	364	54	COPD	COPD	NNP
cord-321401-w4ne60fn	364	55	exacerbation	exacerbation	NN
cord-321401-w4ne60fn	364	56	:	:	:
cord-321401-w4ne60fn	364	57	a	a	DT
cord-321401-w4ne60fn	364	58	randomized	randomized	JJ
cord-321401-w4ne60fn	364	59	clinical	clinical	JJ
cord-321401-w4ne60fn	364	60	trial	trial	NN
cord-321401-w4ne60fn	364	61	study	study	NN
cord-321401-w4ne60fn	364	62	Role	role	NN
cord-321401-w4ne60fn	364	63	of	of	IN
cord-321401-w4ne60fn	364	64	vitamin	vitamin	NN
cord-321401-w4ne60fn	364	65	D	d	NN
cord-321401-w4ne60fn	364	66	in	in	IN
cord-321401-w4ne60fn	364	67	reducing	reduce	VBG
cord-321401-w4ne60fn	364	68	number	number	NN
cord-321401-w4ne60fn	364	69	of	of	IN
cord-321401-w4ne60fn	364	70	acute	acute	JJ
cord-321401-w4ne60fn	364	71	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	364	72	in	in	IN
cord-321401-w4ne60fn	364	73	chronic	chronic	JJ
cord-321401-w4ne60fn	364	74	obstructive	obstructive	JJ
cord-321401-w4ne60fn	364	75	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	364	76	disease	disease	NN
cord-321401-w4ne60fn	364	77	(	(	-LRB-
cord-321401-w4ne60fn	364	78	COPD	COPD	NNP
cord-321401-w4ne60fn	364	79	)	)	-RRB-
cord-321401-w4ne60fn	365	1	patients	patient	NNS
cord-321401-w4ne60fn	365	2	High	high	JJ
cord-321401-w4ne60fn	365	3	doses	dose	NNS
cord-321401-w4ne60fn	365	4	of	of	IN
cord-321401-w4ne60fn	365	5	vitamin	vitamin	NN
cord-321401-w4ne60fn	365	6	D	d	NN
cord-321401-w4ne60fn	365	7	to	to	TO
cord-321401-w4ne60fn	365	8	reduce	reduce	VB
cord-321401-w4ne60fn	365	9	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	365	10	in	in	IN
cord-321401-w4ne60fn	365	11	chronic	chronic	JJ
cord-321401-w4ne60fn	365	12	obstructive	obstructive	JJ
cord-321401-w4ne60fn	365	13	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	365	14	disease	disease	NN
cord-321401-w4ne60fn	365	15	:	:	:
cord-321401-w4ne60fn	365	16	a	a	DT
cord-321401-w4ne60fn	365	17	randomized	randomized	JJ
cord-321401-w4ne60fn	365	18	trial	trial	NN
cord-321401-w4ne60fn	365	19	Vitamin	vitamin	NN
cord-321401-w4ne60fn	365	20	D3	D3	NNP
cord-321401-w4ne60fn	365	21	supplementation	supplementation	NN
cord-321401-w4ne60fn	365	22	in	in	IN
cord-321401-w4ne60fn	365	23	patients	patient	NNS
cord-321401-w4ne60fn	365	24	with	with	IN
cord-321401-w4ne60fn	365	25	chronic	chronic	JJ
cord-321401-w4ne60fn	365	26	obstructive	obstructive	JJ
cord-321401-w4ne60fn	365	27	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	365	28	disease	disease	NN
cord-321401-w4ne60fn	365	29	(	(	-LRB-
cord-321401-w4ne60fn	365	30	ViDiCO	ViDiCO	NNP
cord-321401-w4ne60fn	365	31	)	)	-RRB-
cord-321401-w4ne60fn	365	32	:	:	:
cord-321401-w4ne60fn	365	33	a	a	DT
cord-321401-w4ne60fn	365	34	multicentre	multicentre	NN
cord-321401-w4ne60fn	365	35	,	,	,
cord-321401-w4ne60fn	365	36	double	double	JJ
cord-321401-w4ne60fn	365	37	-	-	HYPH
cord-321401-w4ne60fn	365	38	blind	blind	JJ
cord-321401-w4ne60fn	365	39	,	,	,
cord-321401-w4ne60fn	365	40	randomised	randomised	JJ
cord-321401-w4ne60fn	365	41	controlled	control	VBN
cord-321401-w4ne60fn	365	42	trial	trial	NN
cord-321401-w4ne60fn	365	43	Vitamin	vitamin	NN
cord-321401-w4ne60fn	365	44	D	d	NN
cord-321401-w4ne60fn	365	45	to	to	TO
cord-321401-w4ne60fn	365	46	prevent	prevent	VB
cord-321401-w4ne60fn	365	47	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	365	48	of	of	IN
cord-321401-w4ne60fn	365	49	COPD	COPD	NNP
cord-321401-w4ne60fn	365	50	:	:	:
cord-321401-w4ne60fn	365	51	systematic	systematic	JJ
cord-321401-w4ne60fn	365	52	review	review	NN
cord-321401-w4ne60fn	365	53	and	and	CC
cord-321401-w4ne60fn	365	54	meta	meta	NNP
cord-321401-w4ne60fn	365	55	-	-	HYPH
cord-321401-w4ne60fn	365	56	analysis	analysis	NN
cord-321401-w4ne60fn	365	57	of	of	IN
cord-321401-w4ne60fn	365	58	individual	individual	JJ
cord-321401-w4ne60fn	365	59	participant	participant	NN
cord-321401-w4ne60fn	365	60	data	datum	NNS
cord-321401-w4ne60fn	365	61	from	from	IN
cord-321401-w4ne60fn	365	62	randomised	randomised	JJ
cord-321401-w4ne60fn	365	63	controlled	control	VBN
cord-321401-w4ne60fn	365	64	trials	trial	NNS
cord-321401-w4ne60fn	365	65	Prevention	Prevention	NNP
cord-321401-w4ne60fn	365	66	of	of	IN
cord-321401-w4ne60fn	365	67	exacerbations	exacerbation	NNS
cord-321401-w4ne60fn	365	68	in	in	IN
cord-321401-w4ne60fn	365	69	patients	patient	NNS
cord-321401-w4ne60fn	365	70	with	with	IN
cord-321401-w4ne60fn	365	71	COPD	COPD	NNP
cord-321401-w4ne60fn	365	72	and	and	CC
cord-321401-w4ne60fn	365	73	vitamin	vitamin	NN
cord-321401-w4ne60fn	365	74	D	d	NN
cord-321401-w4ne60fn	365	75	deficiency	deficiency	NN
cord-321401-w4ne60fn	365	76	through	through	IN
cord-321401-w4ne60fn	365	77	vitamin	vitamin	NN
cord-321401-w4ne60fn	365	78	D	D	NNP
cord-321401-w4ne60fn	365	79	supplementation	supplementation	NN
cord-321401-w4ne60fn	365	80	(	(	-LRB-
cord-321401-w4ne60fn	365	81	PRECOVID	PRECOVID	NNP
cord-321401-w4ne60fn	365	82	)	)	-RRB-
cord-321401-w4ne60fn	365	83	:	:	:
cord-321401-w4ne60fn	365	84	a	a	DT
cord-321401-w4ne60fn	365	85	study	study	NN
cord-321401-w4ne60fn	365	86	protocol	protocol	NN
cord-321401-w4ne60fn	365	87	Vitamin	vitamin	NN
cord-321401-w4ne60fn	365	88	D	d	NN
cord-321401-w4ne60fn	365	89	supplementation	supplementation	NN
cord-321401-w4ne60fn	365	90	to	to	TO
cord-321401-w4ne60fn	365	91	prevent	prevent	VB
cord-321401-w4ne60fn	365	92	acute	acute	JJ
cord-321401-w4ne60fn	365	93	respiratory	respiratory	JJ
cord-321401-w4ne60fn	365	94	tract	tract	NN
cord-321401-w4ne60fn	365	95	infections	infection	NNS
cord-321401-w4ne60fn	365	96	:	:	:
cord-321401-w4ne60fn	365	97	systematic	systematic	JJ
cord-321401-w4ne60fn	365	98	review	review	NN
cord-321401-w4ne60fn	365	99	and	and	CC
cord-321401-w4ne60fn	365	100	meta	meta	NNP
cord-321401-w4ne60fn	365	101	-	-	HYPH
cord-321401-w4ne60fn	365	102	analysis	analysis	NN
cord-321401-w4ne60fn	365	103	of	of	IN
cord-321401-w4ne60fn	365	104	individual	individual	JJ
cord-321401-w4ne60fn	365	105	participant	participant	NN
cord-321401-w4ne60fn	365	106	data	data	NNPS
cord-321401-w4ne60fn	365	107	Association	Association	NNP
cord-321401-w4ne60fn	365	108	between	between	IN
cord-321401-w4ne60fn	365	109	vitamin	vitamin	NN
cord-321401-w4ne60fn	365	110	D	d	NN
cord-321401-w4ne60fn	365	111	status	status	NN
cord-321401-w4ne60fn	365	112	and	and	CC
cord-321401-w4ne60fn	365	113	asthma	asthma	NN
cord-321401-w4ne60fn	365	114	control	control	NN
cord-321401-w4ne60fn	365	115	:	:	:
cord-321401-w4ne60fn	365	116	a	a	DT
cord-321401-w4ne60fn	365	117	meta	meta	JJ
cord-321401-w4ne60fn	365	118	-	-	HYPH
cord-321401-w4ne60fn	365	119	analysis	analysis	NN
cord-321401-w4ne60fn	365	120	of	of	IN
cord-321401-w4ne60fn	365	121	randomized	randomized	JJ
cord-321401-w4ne60fn	365	122	trials	trial	NNS
cord-321401-w4ne60fn	365	123	Reduction	reduction	NN
cord-321401-w4ne60fn	365	124	of	of	IN
cord-321401-w4ne60fn	365	125	respiratory	respiratory	JJ
cord-321401-w4ne60fn	365	126	infections	infection	NNS
cord-321401-w4ne60fn	365	127	in	in	IN
cord-321401-w4ne60fn	365	128	asthma	asthma	NN
cord-321401-w4ne60fn	365	129	patients	patient	NNS
cord-321401-w4ne60fn	365	130	supplemented	supplement	VBN
cord-321401-w4ne60fn	365	131	with	with	IN
cord-321401-w4ne60fn	365	132	vitamin	vitamin	NN
cord-321401-w4ne60fn	365	133	D	d	NN
cord-321401-w4ne60fn	365	134	is	be	VBZ
cord-321401-w4ne60fn	365	135	related	relate	VBN
cord-321401-w4ne60fn	365	136	to	to	IN
cord-321401-w4ne60fn	365	137	increased	increase	VBN
cord-321401-w4ne60fn	365	138	serum	serum	NN
cord-321401-w4ne60fn	365	139	IL-10	IL-10	NNP
cord-321401-w4ne60fn	365	140	and	and	CC
cord-321401-w4ne60fn	365	141	IFNγ	IFNγ	NNS
cord-321401-w4ne60fn	365	142	levels	level	NNS
cord-321401-w4ne60fn	365	143	and	and	CC
cord-321401-w4ne60fn	365	144	cathelicidin	cathelicidin	NN
cord-321401-w4ne60fn	365	145	expression	expression	NN
cord-321401-w4ne60fn	365	146	Vitamin	vitamin	NN
cord-321401-w4ne60fn	365	147	D	d	NN
cord-321401-w4ne60fn	365	148	status	status	NN
cord-321401-w4ne60fn	365	149	correlates	correlate	VBZ
cord-321401-w4ne60fn	365	150	with	with	IN
cord-321401-w4ne60fn	365	151	the	the	DT
cord-321401-w4ne60fn	365	152	markers	marker	NNS
cord-321401-w4ne60fn	365	153	of	of	IN
cord-321401-w4ne60fn	365	154	cystic	cystic	JJ
cord-321401-w4ne60fn	365	155	fibrosis	fibrosis	NN
cord-321401-w4ne60fn	365	156	-	-	HYPH
cord-321401-w4ne60fn	365	157	related	relate	VBN
cord-321401-w4ne60fn	365	158	pulmonary	pulmonary	JJ
cord-321401-w4ne60fn	365	159	disease	disease	NN
cord-321401-w4ne60fn	365	160	Vitamin	vitamin	NN
cord-321401-w4ne60fn	365	161	D	d	NN
cord-321401-w4ne60fn	365	162	for	for	IN
cord-321401-w4ne60fn	365	163	the	the	DT
cord-321401-w4ne60fn	365	164	immune	immune	JJ
cord-321401-w4ne60fn	365	165	system	system	NN
cord-321401-w4ne60fn	365	166	in	in	IN
cord-321401-w4ne60fn	365	167	cystic	cystic	JJ
cord-321401-w4ne60fn	365	168	fibrosis	fibrosis	NN
cord-321401-w4ne60fn	365	169	(	(	-LRB-
cord-321401-w4ne60fn	365	170	DISC	DISC	NNP
cord-321401-w4ne60fn	365	171	)	)	-RRB-
cord-321401-w4ne60fn	365	172	:	:	:
cord-321401-w4ne60fn	365	173	a	a	DT
cord-321401-w4ne60fn	365	174	double	double	JJ
cord-321401-w4ne60fn	365	175	-	-	HYPH
cord-321401-w4ne60fn	365	176	blind	blind	JJ
cord-321401-w4ne60fn	365	177	,	,	,
cord-321401-w4ne60fn	365	178	multicenter	multicenter	JJ
cord-321401-w4ne60fn	365	179	,	,	,
cord-321401-w4ne60fn	365	180	randomized	randomized	JJ
cord-321401-w4ne60fn	365	181	,	,	,
cord-321401-w4ne60fn	365	182	placebo	placebo	NN
cord-321401-w4ne60fn	365	183	-	-	HYPH
cord-321401-w4ne60fn	365	184	controlled	control	VBN
cord-321401-w4ne60fn	365	185	clinical	clinical	JJ
cord-321401-w4ne60fn	365	186	trial	trial	NN
cord-321401-w4ne60fn	365	187	24-Hydroxylase	24-hydroxylase	CD
cord-321401-w4ne60fn	365	188	in	in	IN
cord-321401-w4ne60fn	365	189	cancer	cancer	NN
cord-321401-w4ne60fn	365	190	:	:	:
cord-321401-w4ne60fn	365	191	impact	impact	NN
cord-321401-w4ne60fn	365	192	on	on	IN
cord-321401-w4ne60fn	365	193	vitamin	vitamin	NN
cord-321401-w4ne60fn	365	194	D	d	NN
cord-321401-w4ne60fn	365	195	-	-	HYPH
cord-321401-w4ne60fn	365	196	based	base	VBN
cord-321401-w4ne60fn	365	197	anticancer	anticancer	JJ
cord-321401-w4ne60fn	365	198	therapeutics	therapeutic	NNS
cord-321401-w4ne60fn	365	199	Cigarette	Cigarette	NNP
cord-321401-w4ne60fn	365	200	smoke	smoke	NN
cord-321401-w4ne60fn	366	1	modulates	modulate	VBZ
cord-321401-w4ne60fn	366	2	repair	repair	NN
cord-321401-w4ne60fn	366	3	and	and	CC
cord-321401-w4ne60fn	366	4	innate	innate	JJ
cord-321401-w4ne60fn	366	5	immunity	immunity	NN
cord-321401-w4ne60fn	366	6	following	follow	VBG
cord-321401-w4ne60fn	366	7	injury	injury	NN
cord-321401-w4ne60fn	366	8	to	to	IN
cord-321401-w4ne60fn	366	9	airway	airway	JJ
cord-321401-w4ne60fn	366	10	epithelial	epithelial	JJ
cord-321401-w4ne60fn	366	11	cells	cell	NNS
cord-321401-w4ne60fn	366	12	CYP24A1	cyp24a1	VBP
cord-321401-w4ne60fn	366	13	as	as	IN
cord-321401-w4ne60fn	366	14	a	a	DT
cord-321401-w4ne60fn	366	15	potential	potential	JJ
cord-321401-w4ne60fn	366	16	target	target	NN
cord-321401-w4ne60fn	366	17	for	for	IN
cord-321401-w4ne60fn	366	18	cancer	cancer	NN
cord-321401-w4ne60fn	366	19	therapy	therapy	NN
cord-321401-w4ne60fn	366	20	Safer	safe	JJR
cord-321401-w4ne60fn	366	21	approaches	approach	NNS
cord-321401-w4ne60fn	366	22	to	to	IN
cord-321401-w4ne60fn	366	23	therapeutic	therapeutic	JJ
cord-321401-w4ne60fn	366	24	modulation	modulation	NN
cord-321401-w4ne60fn	366	25	of	of	IN
cord-321401-w4ne60fn	366	26	TGF	tgf	NN
cord-321401-w4ne60fn	366	27	-	-	HYPH
cord-321401-w4ne60fn	366	28	beta	beta	NN
cord-321401-w4ne60fn	366	29	signaling	signaling	NN
cord-321401-w4ne60fn	366	30	for	for	IN
cord-321401-w4ne60fn	366	31	respiratory	respiratory	JJ
cord-321401-w4ne60fn	366	32	disease	disease	NN
cord-321401-w4ne60fn	367	1	The	the	DT
cord-321401-w4ne60fn	367	2	authors	author	NNS
cord-321401-w4ne60fn	367	3	declare	declare	VBP
cord-321401-w4ne60fn	367	4	that	that	IN
cord-321401-w4ne60fn	367	5	the	the	DT
cord-321401-w4ne60fn	367	6	research	research	NN
cord-321401-w4ne60fn	367	7	was	be	VBD
cord-321401-w4ne60fn	367	8	conducted	conduct	VBN
cord-321401-w4ne60fn	367	9	in	in	IN
cord-321401-w4ne60fn	367	10	the	the	DT
cord-321401-w4ne60fn	367	11	absence	absence	NN
cord-321401-w4ne60fn	367	12	of	of	IN
cord-321401-w4ne60fn	367	13	any	any	DT
cord-321401-w4ne60fn	367	14	commercial	commercial	JJ
cord-321401-w4ne60fn	367	15	or	or	CC
cord-321401-w4ne60fn	367	16	financial	financial	JJ
cord-321401-w4ne60fn	367	17	relationships	relationship	NNS
cord-321401-w4ne60fn	367	18	that	that	WDT
cord-321401-w4ne60fn	367	19	could	could	MD
cord-321401-w4ne60fn	367	20	be	be	VB
cord-321401-w4ne60fn	367	21	construed	construe	VBN
cord-321401-w4ne60fn	367	22	as	as	IN
cord-321401-w4ne60fn	367	23	a	a	DT
cord-321401-w4ne60fn	367	24	potential	potential	JJ
cord-321401-w4ne60fn	367	25	conflict	conflict	NN
cord-321401-w4ne60fn	367	26	of	of	IN
cord-321401-w4ne60fn	367	27	interest	interest	NN
cord-321401-w4ne60fn	367	28	.	.	.
cord-321401-w4ne60fn	368	1	Copyright	copyright	NN
cord-321401-w4ne60fn	368	2	©	©	NNP
cord-321401-w4ne60fn	368	3	2020	2020	CD
cord-321401-w4ne60fn	368	4	Schrumpf	Schrumpf	NNP
cord-321401-w4ne60fn	368	5	,	,	,
cord-321401-w4ne60fn	368	6	van	van	NNP
cord-321401-w4ne60fn	368	7	der	der	NNP
cord-321401-w4ne60fn	368	8	Does	do	VBZ
cord-321401-w4ne60fn	368	9	and	and	CC
cord-321401-w4ne60fn	368	10	Hiemstra	Hiemstra	NNP
cord-321401-w4ne60fn	368	11	.	.	.
cord-321401-w4ne60fn	369	1	This	this	DT
cord-321401-w4ne60fn	369	2	is	be	VBZ
cord-321401-w4ne60fn	369	3	an	an	DT
cord-321401-w4ne60fn	369	4	open	open	JJ
cord-321401-w4ne60fn	369	5	-	-	HYPH
cord-321401-w4ne60fn	369	6	access	access	NN
cord-321401-w4ne60fn	369	7	article	article	NN
cord-321401-w4ne60fn	369	8	distributed	distribute	VBN
cord-321401-w4ne60fn	369	9	under	under	IN
cord-321401-w4ne60fn	369	10	the	the	DT
cord-321401-w4ne60fn	369	11	terms	term	NNS
cord-321401-w4ne60fn	369	12	of	of	IN
cord-321401-w4ne60fn	369	13	the	the	DT
cord-321401-w4ne60fn	369	14	Creative	Creative	NNP
cord-321401-w4ne60fn	369	15	Commons	Commons	NNP
cord-321401-w4ne60fn	369	16	Attribution	Attribution	NNP
cord-321401-w4ne60fn	369	17	License	License	NNP
cord-321401-w4ne60fn	369	18	(	(	-LRB-
cord-321401-w4ne60fn	369	19	CC	CC	NNP
cord-321401-w4ne60fn	369	20	BY	BY	NNP
cord-321401-w4ne60fn	369	21	)	)	-RRB-
cord-321401-w4ne60fn	369	22	.	.	.
cord-321401-w4ne60fn	370	1	The	the	DT
cord-321401-w4ne60fn	370	2	use	use	NN
cord-321401-w4ne60fn	370	3	,	,	,
cord-321401-w4ne60fn	370	4	distribution	distribution	NN
cord-321401-w4ne60fn	370	5	or	or	CC
cord-321401-w4ne60fn	370	6	reproduction	reproduction	NN
cord-321401-w4ne60fn	370	7	in	in	IN
cord-321401-w4ne60fn	370	8	other	other	JJ
cord-321401-w4ne60fn	370	9	forums	forum	NNS
cord-321401-w4ne60fn	370	10	is	be	VBZ
cord-321401-w4ne60fn	370	11	permitted	permit	VBN
cord-321401-w4ne60fn	370	12	,	,	,
cord-321401-w4ne60fn	370	13	provided	provide	VBD
cord-321401-w4ne60fn	370	14	the	the	DT
cord-321401-w4ne60fn	370	15	original	original	JJ
cord-321401-w4ne60fn	370	16	author(s	author(s	NNP
cord-321401-w4ne60fn	370	17	)	)	-RRB-
cord-321401-w4ne60fn	370	18	and	and	CC
cord-321401-w4ne60fn	370	19	the	the	DT
cord-321401-w4ne60fn	370	20	copyright	copyright	NN
cord-321401-w4ne60fn	370	21	owner(s	owner(s	NNP
cord-321401-w4ne60fn	370	22	)	)	-RRB-
cord-321401-w4ne60fn	370	23	are	be	VBP
cord-321401-w4ne60fn	370	24	credited	credit	VBN
cord-321401-w4ne60fn	370	25	and	and	CC
cord-321401-w4ne60fn	370	26	that	that	IN
cord-321401-w4ne60fn	370	27	the	the	DT
cord-321401-w4ne60fn	370	28	original	original	JJ
cord-321401-w4ne60fn	370	29	publication	publication	NN
cord-321401-w4ne60fn	370	30	in	in	IN
cord-321401-w4ne60fn	370	31	this	this	DT
cord-321401-w4ne60fn	370	32	journal	journal	NN
cord-321401-w4ne60fn	370	33	is	be	VBZ
cord-321401-w4ne60fn	370	34	cited	cite	VBN
cord-321401-w4ne60fn	370	35	,	,	,
cord-321401-w4ne60fn	370	36	in	in	IN
cord-321401-w4ne60fn	370	37	accordance	accordance	NN
cord-321401-w4ne60fn	370	38	with	with	IN
cord-321401-w4ne60fn	370	39	accepted	accepted	JJ
cord-321401-w4ne60fn	370	40	academic	academic	JJ
cord-321401-w4ne60fn	370	41	practice	practice	NN
cord-321401-w4ne60fn	370	42	.	.	.
cord-321401-w4ne60fn	371	1	No	no	DT
cord-321401-w4ne60fn	371	2	use	use	NN
cord-321401-w4ne60fn	371	3	,	,	,
cord-321401-w4ne60fn	371	4	distribution	distribution	NN
cord-321401-w4ne60fn	371	5	or	or	CC
cord-321401-w4ne60fn	371	6	reproduction	reproduction	NN
cord-321401-w4ne60fn	371	7	is	be	VBZ
cord-321401-w4ne60fn	371	8	permitted	permit	VBN
cord-321401-w4ne60fn	371	9	which	which	WDT
cord-321401-w4ne60fn	371	10	does	do	VBZ
cord-321401-w4ne60fn	371	11	not	not	RB
cord-321401-w4ne60fn	371	12	comply	comply	VB
cord-321401-w4ne60fn	371	13	with	with	IN
cord-321401-w4ne60fn	371	14	these	these	DT
cord-321401-w4ne60fn	371	15	terms	term	NNS
cord-321401-w4ne60fn	371	16	.	.	.