id	sid	tid	token	lemma	pos
cord-006788-kz8i4a6h	1	1	key	key	NN
cord-006788-kz8i4a6h	1	2	:	:	:
cord-006788-kz8i4a6h	2	1	cord-006788-kz8i4a6h	cord-006788-kz8i4a6h	JJ
cord-006788-kz8i4a6h	2	2	authors	author	NNS
cord-006788-kz8i4a6h	2	3	:	:	:
cord-006788-kz8i4a6h	2	4	Li	Li	NNP
cord-006788-kz8i4a6h	2	5	,	,	,
cord-006788-kz8i4a6h	2	6	Xiaokun	Xiaokun	NNP
cord-006788-kz8i4a6h	2	7	title	title	NN
cord-006788-kz8i4a6h	2	8	:	:	:
cord-006788-kz8i4a6h	3	1	The	the	DT
cord-006788-kz8i4a6h	3	2	FGF	FGF	NNP
cord-006788-kz8i4a6h	3	3	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	3	4	axis	axis	NN
cord-006788-kz8i4a6h	3	5	date	date	NN
cord-006788-kz8i4a6h	3	6	:	:	:
cord-006788-kz8i4a6h	3	7	2019	2019	CD
cord-006788-kz8i4a6h	3	8	-	-	HYPH
cord-006788-kz8i4a6h	3	9	09	09	CD
cord-006788-kz8i4a6h	3	10	-	-	HYPH
cord-006788-kz8i4a6h	3	11	07	07	CD
cord-006788-kz8i4a6h	3	12	journal	journal	NN
cord-006788-kz8i4a6h	3	13	:	:	:
cord-006788-kz8i4a6h	4	1	Front	front	JJ
cord-006788-kz8i4a6h	4	2	Med	Med	NNP
cord-006788-kz8i4a6h	4	3	DOI	doi	NN
cord-006788-kz8i4a6h	4	4	:	:	:
cord-006788-kz8i4a6h	4	5	10.1007	10.1007	CD
cord-006788-kz8i4a6h	4	6	/	/	SYM
cord-006788-kz8i4a6h	4	7	s11684	s11684	NN
cord-006788-kz8i4a6h	4	8	-	-	HYPH
cord-006788-kz8i4a6h	4	9	019	019	NNP
cord-006788-kz8i4a6h	4	10	-	-	HYPH
cord-006788-kz8i4a6h	4	11	0711-y	0711-y	CD
cord-006788-kz8i4a6h	5	1	sha	sha	NNP
cord-006788-kz8i4a6h	5	2	:	:	:
cord-006788-kz8i4a6h	6	1	8039da1d9042895eaca609527a67f21e3b66c4a2	8039da1d9042895eaca609527a67f21e3b66c4a2	CD
cord-006788-kz8i4a6h	6	2	doc_id	doc_id	CD
cord-006788-kz8i4a6h	6	3	:	:	:
cord-006788-kz8i4a6h	7	1	6788	6788	CD
cord-006788-kz8i4a6h	7	2	cord_uid	cord_uid	NN
cord-006788-kz8i4a6h	7	3	:	:	:
cord-006788-kz8i4a6h	8	1	kz8i4a6h	kz8i4a6h	NNP
cord-006788-kz8i4a6h	8	2	Members	Members	NNPS
cord-006788-kz8i4a6h	8	3	of	of	IN
cord-006788-kz8i4a6h	8	4	the	the	DT
cord-006788-kz8i4a6h	8	5	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	8	6	growth	growth	NN
cord-006788-kz8i4a6h	8	7	factor	factor	NN
cord-006788-kz8i4a6h	8	8	(	(	-LRB-
cord-006788-kz8i4a6h	8	9	FGF	FGF	NNP
cord-006788-kz8i4a6h	8	10	)	)	-RRB-
cord-006788-kz8i4a6h	8	11	family	family	NN
cord-006788-kz8i4a6h	8	12	play	play	VBP
cord-006788-kz8i4a6h	8	13	pleiotropic	pleiotropic	JJ
cord-006788-kz8i4a6h	8	14	roles	role	NNS
cord-006788-kz8i4a6h	8	15	in	in	IN
cord-006788-kz8i4a6h	8	16	cellular	cellular	JJ
cord-006788-kz8i4a6h	8	17	and	and	CC
cord-006788-kz8i4a6h	8	18	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	8	19	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	8	20	.	.	.
cord-006788-kz8i4a6h	9	1	During	during	IN
cord-006788-kz8i4a6h	9	2	evolution	evolution	NN
cord-006788-kz8i4a6h	9	3	,	,	,
cord-006788-kz8i4a6h	9	4	the	the	DT
cord-006788-kz8i4a6h	9	5	ancestor	ancestor	NN
cord-006788-kz8i4a6h	9	6	FGF	FGF	NNP
cord-006788-kz8i4a6h	9	7	expands	expand	VBZ
cord-006788-kz8i4a6h	9	8	into	into	IN
cord-006788-kz8i4a6h	9	9	multiple	multiple	JJ
cord-006788-kz8i4a6h	9	10	members	member	NNS
cord-006788-kz8i4a6h	9	11	by	by	IN
cord-006788-kz8i4a6h	9	12	acquiring	acquire	VBG
cord-006788-kz8i4a6h	9	13	divergent	divergent	JJ
cord-006788-kz8i4a6h	9	14	structural	structural	JJ
cord-006788-kz8i4a6h	9	15	elements	element	NNS
cord-006788-kz8i4a6h	9	16	that	that	WDT
cord-006788-kz8i4a6h	9	17	enable	enable	VBP
cord-006788-kz8i4a6h	9	18	functional	functional	JJ
cord-006788-kz8i4a6h	9	19	divergence	divergence	NN
cord-006788-kz8i4a6h	9	20	and	and	CC
cord-006788-kz8i4a6h	9	21	specification	specification	NN
cord-006788-kz8i4a6h	9	22	.	.	.
cord-006788-kz8i4a6h	10	1	Heparan	heparan	JJ
cord-006788-kz8i4a6h	10	2	sulfate	sulfate	NN
cord-006788-kz8i4a6h	10	3	-	-	HYPH
cord-006788-kz8i4a6h	10	4	binding	bind	VBG
cord-006788-kz8i4a6h	10	5	FGFs	fgf	NNS
cord-006788-kz8i4a6h	10	6	,	,	,
cord-006788-kz8i4a6h	10	7	which	which	WDT
cord-006788-kz8i4a6h	10	8	play	play	VBP
cord-006788-kz8i4a6h	10	9	critical	critical	JJ
cord-006788-kz8i4a6h	10	10	roles	role	NNS
cord-006788-kz8i4a6h	10	11	in	in	IN
cord-006788-kz8i4a6h	10	12	embryonic	embryonic	JJ
cord-006788-kz8i4a6h	10	13	development	development	NN
cord-006788-kz8i4a6h	10	14	and	and	CC
cord-006788-kz8i4a6h	10	15	adult	adult	NN
cord-006788-kz8i4a6h	10	16	tissue	tissue	NN
cord-006788-kz8i4a6h	10	17	remodeling	remodel	VBG
cord-006788-kz8i4a6h	10	18	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	10	19	,	,	,
cord-006788-kz8i4a6h	10	20	adapt	adapt	VB
cord-006788-kz8i4a6h	10	21	to	to	IN
cord-006788-kz8i4a6h	10	22	an	an	DT
cord-006788-kz8i4a6h	10	23	autocrine	autocrine	JJ
cord-006788-kz8i4a6h	10	24	/	/	SYM
cord-006788-kz8i4a6h	10	25	paracrine	paracrine	NN
cord-006788-kz8i4a6h	10	26	mode	mode	NN
cord-006788-kz8i4a6h	10	27	of	of	IN
cord-006788-kz8i4a6h	10	28	action	action	NN
cord-006788-kz8i4a6h	10	29	to	to	TO
cord-006788-kz8i4a6h	10	30	promote	promote	VB
cord-006788-kz8i4a6h	10	31	cell	cell	NN
cord-006788-kz8i4a6h	10	32	proliferation	proliferation	NN
cord-006788-kz8i4a6h	10	33	and	and	CC
cord-006788-kz8i4a6h	10	34	population	population	NN
cord-006788-kz8i4a6h	10	35	growth	growth	NN
cord-006788-kz8i4a6h	10	36	.	.	.
cord-006788-kz8i4a6h	11	1	By	by	IN
cord-006788-kz8i4a6h	11	2	contrast	contrast	NN
cord-006788-kz8i4a6h	11	3	,	,	,
cord-006788-kz8i4a6h	11	4	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	11	5	,	,	,
cord-006788-kz8i4a6h	11	6	21	21	CD
cord-006788-kz8i4a6h	11	7	,	,	,
cord-006788-kz8i4a6h	11	8	and	and	CC
cord-006788-kz8i4a6h	11	9	23	23	CD
cord-006788-kz8i4a6h	11	10	coevolve	coevolve	RB
cord-006788-kz8i4a6h	11	11	through	through	IN
cord-006788-kz8i4a6h	11	12	losing	lose	VBG
cord-006788-kz8i4a6h	11	13	binding	bind	VBG
cord-006788-kz8i4a6h	11	14	affinity	affinity	NN
cord-006788-kz8i4a6h	11	15	for	for	IN
cord-006788-kz8i4a6h	11	16	extracellular	extracellular	JJ
cord-006788-kz8i4a6h	11	17	matrix	matrix	NN
cord-006788-kz8i4a6h	11	18	heparan	heparan	NN
cord-006788-kz8i4a6h	11	19	sulfate	sulfate	NN
cord-006788-kz8i4a6h	11	20	while	while	IN
cord-006788-kz8i4a6h	11	21	acquiring	acquire	VBG
cord-006788-kz8i4a6h	11	22	affinity	affinity	NN
cord-006788-kz8i4a6h	11	23	for	for	IN
cord-006788-kz8i4a6h	11	24	transmembrane	transmembrane	NNP
cord-006788-kz8i4a6h	11	25	α	α	NNP
cord-006788-kz8i4a6h	11	26	-	-	HYPH
cord-006788-kz8i4a6h	11	27	Klotho	Klotho	NNP
cord-006788-kz8i4a6h	11	28	(	(	-LRB-
cord-006788-kz8i4a6h	11	29	KL	KL	NNP
cord-006788-kz8i4a6h	11	30	)	)	-RRB-
cord-006788-kz8i4a6h	11	31	or	or	CC
cord-006788-kz8i4a6h	11	32	β	β	NN
cord-006788-kz8i4a6h	11	33	-	-	HYPH
cord-006788-kz8i4a6h	11	34	KL	KL	NNP
cord-006788-kz8i4a6h	11	35	as	as	IN
cord-006788-kz8i4a6h	11	36	a	a	DT
cord-006788-kz8i4a6h	11	37	coreceptor	coreceptor	NN
cord-006788-kz8i4a6h	11	38	,	,	,
cord-006788-kz8i4a6h	11	39	thereby	thereby	RB
cord-006788-kz8i4a6h	11	40	adapting	adapt	VBG
cord-006788-kz8i4a6h	11	41	to	to	IN
cord-006788-kz8i4a6h	11	42	an	an	DT
cord-006788-kz8i4a6h	11	43	endocrine	endocrine	JJ
cord-006788-kz8i4a6h	11	44	mode	mode	NN
cord-006788-kz8i4a6h	11	45	of	of	IN
cord-006788-kz8i4a6h	11	46	action	action	NN
cord-006788-kz8i4a6h	11	47	to	to	TO
cord-006788-kz8i4a6h	11	48	drive	drive	VB
cord-006788-kz8i4a6h	11	49	interorgan	interorgan	NN
cord-006788-kz8i4a6h	11	50	crosstalk	crosstalk	NN
cord-006788-kz8i4a6h	11	51	that	that	WDT
cord-006788-kz8i4a6h	11	52	regulates	regulate	VBZ
cord-006788-kz8i4a6h	11	53	a	a	DT
cord-006788-kz8i4a6h	11	54	broad	broad	JJ
cord-006788-kz8i4a6h	11	55	spectrum	spectrum	NN
cord-006788-kz8i4a6h	11	56	of	of	IN
cord-006788-kz8i4a6h	11	57	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	11	58	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	11	59	.	.	.
cord-006788-kz8i4a6h	12	1	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	12	2	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	12	3	axis	axis	NN
cord-006788-kz8i4a6h	12	4	from	from	IN
cord-006788-kz8i4a6h	12	5	the	the	DT
cord-006788-kz8i4a6h	12	6	ileum	ileum	NN
cord-006788-kz8i4a6h	12	7	to	to	IN
cord-006788-kz8i4a6h	12	8	liver	liver	NN
cord-006788-kz8i4a6h	12	9	negatively	negatively	RB
cord-006788-kz8i4a6h	12	10	controls	control	VBZ
cord-006788-kz8i4a6h	12	11	diurnal	diurnal	JJ
cord-006788-kz8i4a6h	12	12	bile	bile	NN
cord-006788-kz8i4a6h	12	13	acid	acid	NN
cord-006788-kz8i4a6h	12	14	biosynthesis	biosynthesis	NN
cord-006788-kz8i4a6h	12	15	.	.	.
cord-006788-kz8i4a6h	13	1	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	13	2	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	13	3	axes	axis	NNS
cord-006788-kz8i4a6h	13	4	play	play	VBP
cord-006788-kz8i4a6h	13	5	multifaceted	multifacete	VBN
cord-006788-kz8i4a6h	13	6	roles	role	NNS
cord-006788-kz8i4a6h	13	7	in	in	IN
cord-006788-kz8i4a6h	13	8	controlling	control	VBG
cord-006788-kz8i4a6h	13	9	the	the	DT
cord-006788-kz8i4a6h	13	10	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	13	11	of	of	IN
cord-006788-kz8i4a6h	13	12	lipid	lipid	NN
cord-006788-kz8i4a6h	13	13	,	,	,
cord-006788-kz8i4a6h	13	14	glucose	glucose	NN
cord-006788-kz8i4a6h	13	15	,	,	,
cord-006788-kz8i4a6h	13	16	and	and	CC
cord-006788-kz8i4a6h	13	17	energy	energy	NN
cord-006788-kz8i4a6h	13	18	metabolism	metabolism	NN
cord-006788-kz8i4a6h	13	19	.	.	.
cord-006788-kz8i4a6h	14	1	FGF23	fgf23	NN
cord-006788-kz8i4a6h	14	2	axes	axis	NNS
cord-006788-kz8i4a6h	14	3	from	from	IN
cord-006788-kz8i4a6h	14	4	the	the	DT
cord-006788-kz8i4a6h	14	5	bone	bone	NN
cord-006788-kz8i4a6h	14	6	to	to	IN
cord-006788-kz8i4a6h	14	7	kidney	kidney	NN
cord-006788-kz8i4a6h	14	8	and	and	CC
cord-006788-kz8i4a6h	14	9	parathyroid	parathyroid	NN
cord-006788-kz8i4a6h	14	10	regulate	regulate	VBP
cord-006788-kz8i4a6h	14	11	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	14	12	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	14	13	of	of	IN
cord-006788-kz8i4a6h	14	14	phosphate	phosphate	NN
cord-006788-kz8i4a6h	14	15	,	,	,
cord-006788-kz8i4a6h	14	16	calcium	calcium	NN
cord-006788-kz8i4a6h	14	17	,	,	,
cord-006788-kz8i4a6h	14	18	vitamin	vitamin	NN
cord-006788-kz8i4a6h	14	19	D	d	NN
cord-006788-kz8i4a6h	14	20	,	,	,
cord-006788-kz8i4a6h	14	21	and	and	CC
cord-006788-kz8i4a6h	14	22	parathyroid	parathyroid	JJ
cord-006788-kz8i4a6h	14	23	hormone	hormone	NN
cord-006788-kz8i4a6h	14	24	that	that	WDT
cord-006788-kz8i4a6h	14	25	are	be	VBP
cord-006788-kz8i4a6h	14	26	important	important	JJ
cord-006788-kz8i4a6h	14	27	for	for	IN
cord-006788-kz8i4a6h	14	28	bone	bone	NN
cord-006788-kz8i4a6h	14	29	health	health	NN
cord-006788-kz8i4a6h	14	30	and	and	CC
cord-006788-kz8i4a6h	14	31	systemic	systemic	JJ
cord-006788-kz8i4a6h	14	32	mineral	mineral	NN
cord-006788-kz8i4a6h	14	33	balance	balance	NN
cord-006788-kz8i4a6h	14	34	.	.	.
cord-006788-kz8i4a6h	15	1	The	the	DT
cord-006788-kz8i4a6h	15	2	significant	significant	JJ
cord-006788-kz8i4a6h	15	3	divergence	divergence	NN
cord-006788-kz8i4a6h	15	4	in	in	IN
cord-006788-kz8i4a6h	15	5	structural	structural	JJ
cord-006788-kz8i4a6h	15	6	elements	element	NNS
cord-006788-kz8i4a6h	15	7	and	and	CC
cord-006788-kz8i4a6h	15	8	multiple	multiple	JJ
cord-006788-kz8i4a6h	15	9	functional	functional	JJ
cord-006788-kz8i4a6h	15	10	specifications	specification	NNS
cord-006788-kz8i4a6h	15	11	of	of	IN
cord-006788-kz8i4a6h	15	12	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	15	13	,	,	,
cord-006788-kz8i4a6h	15	14	21	21	CD
cord-006788-kz8i4a6h	15	15	,	,	,
cord-006788-kz8i4a6h	15	16	and	and	CC
cord-006788-kz8i4a6h	15	17	23	23	CD
cord-006788-kz8i4a6h	15	18	in	in	IN
cord-006788-kz8i4a6h	15	19	cellular	cellular	JJ
cord-006788-kz8i4a6h	15	20	and	and	CC
cord-006788-kz8i4a6h	15	21	organismal	organismal	JJ
cord-006788-kz8i4a6h	15	22	metabolism	metabolism	NN
cord-006788-kz8i4a6h	15	23	instead	instead	RB
cord-006788-kz8i4a6h	15	24	of	of	IN
cord-006788-kz8i4a6h	15	25	cell	cell	NN
cord-006788-kz8i4a6h	15	26	proliferation	proliferation	NN
cord-006788-kz8i4a6h	15	27	and	and	CC
cord-006788-kz8i4a6h	15	28	growth	growth	NN
cord-006788-kz8i4a6h	15	29	sufficiently	sufficiently	RB
cord-006788-kz8i4a6h	15	30	necessitate	necessitate	VBP
cord-006788-kz8i4a6h	15	31	a	a	DT
cord-006788-kz8i4a6h	15	32	new	new	JJ
cord-006788-kz8i4a6h	15	33	unified	unified	JJ
cord-006788-kz8i4a6h	15	34	and	and	CC
cord-006788-kz8i4a6h	15	35	specific	specific	JJ
cord-006788-kz8i4a6h	15	36	term	term	NN
cord-006788-kz8i4a6h	15	37	for	for	IN
cord-006788-kz8i4a6h	15	38	these	these	DT
cord-006788-kz8i4a6h	15	39	three	three	CD
cord-006788-kz8i4a6h	15	40	endocrine	endocrine	JJ
cord-006788-kz8i4a6h	15	41	FGFs	fgf	NNS
cord-006788-kz8i4a6h	15	42	.	.	.
cord-006788-kz8i4a6h	16	1	Thus	thus	RB
cord-006788-kz8i4a6h	16	2	,	,	,
cord-006788-kz8i4a6h	16	3	the	the	DT
cord-006788-kz8i4a6h	16	4	term	term	NN
cord-006788-kz8i4a6h	16	5	“	"	``
cord-006788-kz8i4a6h	16	6	FGF	FGF	NNP
cord-006788-kz8i4a6h	16	7	Metabolic	Metabolic	NNP
cord-006788-kz8i4a6h	16	8	Axis	Axis	NNP
cord-006788-kz8i4a6h	16	9	,	,	,
cord-006788-kz8i4a6h	16	10	”	"	''
cord-006788-kz8i4a6h	16	11	which	which	WDT
cord-006788-kz8i4a6h	16	12	distinguishes	distinguish	VBZ
cord-006788-kz8i4a6h	16	13	the	the	DT
cord-006788-kz8i4a6h	16	14	unique	unique	JJ
cord-006788-kz8i4a6h	16	15	pathways	pathway	NNS
cord-006788-kz8i4a6h	16	16	and	and	CC
cord-006788-kz8i4a6h	16	17	functions	function	NNS
cord-006788-kz8i4a6h	16	18	of	of	IN
cord-006788-kz8i4a6h	16	19	endocrine	endocrine	JJ
cord-006788-kz8i4a6h	16	20	FGFs	fgf	NNS
cord-006788-kz8i4a6h	16	21	from	from	IN
cord-006788-kz8i4a6h	16	22	other	other	JJ
cord-006788-kz8i4a6h	16	23	autocrine	autocrine	NN
cord-006788-kz8i4a6h	16	24	/	/	SYM
cord-006788-kz8i4a6h	16	25	paracrine	paracrine	JJ
cord-006788-kz8i4a6h	16	26	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	16	27	FGFs	fgf	NNS
cord-006788-kz8i4a6h	16	28	,	,	,
cord-006788-kz8i4a6h	16	29	is	be	VBZ
cord-006788-kz8i4a6h	16	30	coined	coin	VBN
cord-006788-kz8i4a6h	16	31	.	.	.
cord-006788-kz8i4a6h	17	1	Fibroblast	fibroblast	JJ
cord-006788-kz8i4a6h	17	2	growth	growth	NN
cord-006788-kz8i4a6h	17	3	factors	factor	NNS
cord-006788-kz8i4a6h	17	4	(	(	-LRB-
cord-006788-kz8i4a6h	17	5	FGFs	fgf	NNS
cord-006788-kz8i4a6h	17	6	)	)	-RRB-
cord-006788-kz8i4a6h	17	7	are	be	VBP
cord-006788-kz8i4a6h	17	8	pleiotropic	pleiotropic	JJ
cord-006788-kz8i4a6h	17	9	signal	signal	NN
cord-006788-kz8i4a6h	17	10	molecules	molecule	NNS
cord-006788-kz8i4a6h	17	11	for	for	IN
cord-006788-kz8i4a6h	17	12	all	all	DT
cord-006788-kz8i4a6h	17	13	types	type	NNS
cord-006788-kz8i4a6h	17	14	of	of	IN
cord-006788-kz8i4a6h	17	15	cell	cell	NN
cord-006788-kz8i4a6h	17	16	and	and	CC
cord-006788-kz8i4a6h	17	17	tissue	tissue	NN
cord-006788-kz8i4a6h	17	18	systems	system	NNS
cord-006788-kz8i4a6h	17	19	in	in	IN
cord-006788-kz8i4a6h	17	20	metazoans	metazoans	NNP
cord-006788-kz8i4a6h	17	21	[	[	-LRB-
cord-006788-kz8i4a6h	17	22	1	1	CD
cord-006788-kz8i4a6h	17	23	]	]	-RRB-
cord-006788-kz8i4a6h	17	24	[	[	-LRB-
cord-006788-kz8i4a6h	17	25	2	2	CD
cord-006788-kz8i4a6h	17	26	]	]	-RRB-
cord-006788-kz8i4a6h	17	27	[	[	-LRB-
cord-006788-kz8i4a6h	17	28	3	3	CD
cord-006788-kz8i4a6h	17	29	]	]	-RRB-
cord-006788-kz8i4a6h	17	30	.	.	.
cord-006788-kz8i4a6h	18	1	FGFs	fgf	NNS
cord-006788-kz8i4a6h	18	2	share	share	VBP
cord-006788-kz8i4a6h	18	3	a	a	DT
cord-006788-kz8i4a6h	18	4	conserved	conserve	VBN
cord-006788-kz8i4a6h	18	5	core	core	NN
cord-006788-kz8i4a6h	18	6	structure	structure	NN
cord-006788-kz8i4a6h	18	7	of	of	IN
cord-006788-kz8i4a6h	18	8	β	β	NN
cord-006788-kz8i4a6h	18	9	-	-	HYPH
cord-006788-kz8i4a6h	18	10	trefoil	trefoil	NN
cord-006788-kz8i4a6h	18	11	fold	fold	NN
cord-006788-kz8i4a6h	18	12	consisting	consisting	NN
cord-006788-kz8i4a6h	18	13	of	of	IN
cord-006788-kz8i4a6h	18	14	12-stranded	12-stranded	CD
cord-006788-kz8i4a6h	18	15	β	β	NN
cord-006788-kz8i4a6h	18	16	-	-	HYPH
cord-006788-kz8i4a6h	18	17	sheets	sheet	NNS
cord-006788-kz8i4a6h	18	18	arranged	arrange	VBN
cord-006788-kz8i4a6h	18	19	in	in	IN
cord-006788-kz8i4a6h	18	20	three	three	CD
cord-006788-kz8i4a6h	18	21	similar	similar	JJ
cord-006788-kz8i4a6h	18	22	lobes	lobe	NNS
cord-006788-kz8i4a6h	18	23	around	around	IN
cord-006788-kz8i4a6h	18	24	a	a	DT
cord-006788-kz8i4a6h	18	25	central	central	JJ
cord-006788-kz8i4a6h	18	26	axis	axis	NN
cord-006788-kz8i4a6h	18	27	,	,	,
cord-006788-kz8i4a6h	18	28	of	of	IN
cord-006788-kz8i4a6h	18	29	which	which	WDT
cord-006788-kz8i4a6h	18	30	six	six	CD
cord-006788-kz8i4a6h	18	31	strands	strand	NNS
cord-006788-kz8i4a6h	18	32	form	form	VBP
cord-006788-kz8i4a6h	18	33	an	an	DT
cord-006788-kz8i4a6h	18	34	antiparallel	antiparallel	NN
cord-006788-kz8i4a6h	18	35	β	β	NN
cord-006788-kz8i4a6h	18	36	-	-	HYPH
cord-006788-kz8i4a6h	18	37	barrel	barrel	NN
cord-006788-kz8i4a6h	18	38	[	[	-LRB-
cord-006788-kz8i4a6h	18	39	4	4	CD
cord-006788-kz8i4a6h	18	40	,	,	,
cord-006788-kz8i4a6h	18	41	5	5	CD
cord-006788-kz8i4a6h	18	42	]	]	-RRB-
cord-006788-kz8i4a6h	18	43	.	.	.
cord-006788-kz8i4a6h	19	1	Except	except	IN
cord-006788-kz8i4a6h	19	2	for	for	IN
cord-006788-kz8i4a6h	19	3	the	the	DT
cord-006788-kz8i4a6h	19	4	four	four	CD
cord-006788-kz8i4a6h	19	5	FGF	FGF	NNP
cord-006788-kz8i4a6h	19	6	-	-	HYPH
cord-006788-kz8i4a6h	19	7	homologous	homologous	JJ
cord-006788-kz8i4a6h	19	8	intracrine	intracrine	JJ
cord-006788-kz8i4a6h	19	9	factors	factor	NNS
cord-006788-kz8i4a6h	19	10	that	that	WDT
cord-006788-kz8i4a6h	19	11	are	be	VBP
cord-006788-kz8i4a6h	19	12	functionally	functionally	RB
cord-006788-kz8i4a6h	19	13	reminiscent	reminiscent	JJ
cord-006788-kz8i4a6h	19	14	of	of	IN
cord-006788-kz8i4a6h	19	15	the	the	DT
cord-006788-kz8i4a6h	19	16	ancestor	ancestor	NN
cord-006788-kz8i4a6h	19	17	FGF	FGF	NNP
cord-006788-kz8i4a6h	19	18	,	,	,
cord-006788-kz8i4a6h	19	19	the	the	DT
cord-006788-kz8i4a6h	19	20	FGFs	fgf	NNS
cord-006788-kz8i4a6h	19	21	can	can	MD
cord-006788-kz8i4a6h	19	22	be	be	VB
cord-006788-kz8i4a6h	19	23	classified	classify	VBN
cord-006788-kz8i4a6h	19	24	into	into	IN
cord-006788-kz8i4a6h	19	25	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	19	26	and	and	CC
cord-006788-kz8i4a6h	19	27	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	19	28	FGFs	fgf	NNS
cord-006788-kz8i4a6h	19	29	,	,	,
cord-006788-kz8i4a6h	19	30	which	which	WDT
cord-006788-kz8i4a6h	19	31	overtly	overtly	RB
cord-006788-kz8i4a6h	19	32	regulate	regulate	VBP
cord-006788-kz8i4a6h	19	33	cellular	cellular	JJ
cord-006788-kz8i4a6h	19	34	proliferation	proliferation	NN
cord-006788-kz8i4a6h	19	35	and	and	CC
cord-006788-kz8i4a6h	19	36	substrate	substrate	NN
cord-006788-kz8i4a6h	19	37	/	/	SYM
cord-006788-kz8i4a6h	19	38	energy	energy	NN
cord-006788-kz8i4a6h	19	39	metabolism	metabolism	NN
cord-006788-kz8i4a6h	19	40	,	,	,
cord-006788-kz8i4a6h	19	41	respectively	respectively	RB
cord-006788-kz8i4a6h	19	42	,	,	,
cord-006788-kz8i4a6h	19	43	on	on	IN
cord-006788-kz8i4a6h	19	44	the	the	DT
cord-006788-kz8i4a6h	19	45	basis	basis	NN
cord-006788-kz8i4a6h	19	46	of	of	IN
cord-006788-kz8i4a6h	19	47	their	-PRON-	PRP$
cord-006788-kz8i4a6h	19	48	distinct	distinct	JJ
cord-006788-kz8i4a6h	19	49	functions	function	NNS
cord-006788-kz8i4a6h	19	50	and	and	CC
cord-006788-kz8i4a6h	19	51	endpoint	endpoint	VB
cord-006788-kz8i4a6h	19	52	biological	biological	JJ
cord-006788-kz8i4a6h	19	53	effects	effect	NNS
cord-006788-kz8i4a6h	19	54	[	[	-LRB-
cord-006788-kz8i4a6h	19	55	6	6	CD
cord-006788-kz8i4a6h	19	56	,	,	,
cord-006788-kz8i4a6h	19	57	7	7	CD
cord-006788-kz8i4a6h	19	58	]	]	-RRB-
cord-006788-kz8i4a6h	19	59	.	.	.
cord-006788-kz8i4a6h	20	1	Both	both	DT
cord-006788-kz8i4a6h	20	2	FGF	FGF	NNP
cord-006788-kz8i4a6h	20	3	classes	class	NNS
cord-006788-kz8i4a6h	20	4	signal	signal	VBP
cord-006788-kz8i4a6h	20	5	through	through	IN
cord-006788-kz8i4a6h	20	6	the	the	DT
cord-006788-kz8i4a6h	20	7	same	same	JJ
cord-006788-kz8i4a6h	20	8	types	type	NNS
cord-006788-kz8i4a6h	20	9	of	of	IN
cord-006788-kz8i4a6h	20	10	transmembrane	transmembrane	NN
cord-006788-kz8i4a6h	20	11	receptor	receptor	NN
cord-006788-kz8i4a6h	20	12	tyrosine	tyrosine	NN
cord-006788-kz8i4a6h	20	13	kinases	kinase	NNS
cord-006788-kz8i4a6h	20	14	,	,	,
cord-006788-kz8i4a6h	20	15	that	that	RB
cord-006788-kz8i4a6h	20	16	is	is	RB
cord-006788-kz8i4a6h	20	17	,	,	,
cord-006788-kz8i4a6h	20	18	the	the	DT
cord-006788-kz8i4a6h	20	19	FGF	FGF	NNP
cord-006788-kz8i4a6h	20	20	receptors	receptor	NNS
cord-006788-kz8i4a6h	20	21	(	(	-LRB-
cord-006788-kz8i4a6h	20	22	FGFRs	fgfr	NNS
cord-006788-kz8i4a6h	20	23	)	)	-RRB-
cord-006788-kz8i4a6h	20	24	1	1	CD
cord-006788-kz8i4a6h	20	25	to	to	IN
cord-006788-kz8i4a6h	20	26	4	4	CD
cord-006788-kz8i4a6h	20	27	with	with	IN
cord-006788-kz8i4a6h	20	28	multiple	multiple	JJ
cord-006788-kz8i4a6h	20	29	splicing	splicing	NN
cord-006788-kz8i4a6h	20	30	variants	variant	NNS
cord-006788-kz8i4a6h	20	31	[	[	-LRB-
cord-006788-kz8i4a6h	20	32	8	8	CD
cord-006788-kz8i4a6h	20	33	]	]	-RRB-
cord-006788-kz8i4a6h	20	34	.	.	.
cord-006788-kz8i4a6h	21	1	However	however	RB
cord-006788-kz8i4a6h	21	2	,	,	,
cord-006788-kz8i4a6h	21	3	in	in	IN
cord-006788-kz8i4a6h	21	4	physiology	physiology	NN
cord-006788-kz8i4a6h	21	5	,	,	,
cord-006788-kz8i4a6h	21	6	these	these	DT
cord-006788-kz8i4a6h	21	7	two	two	CD
cord-006788-kz8i4a6h	21	8	types	type	NNS
cord-006788-kz8i4a6h	21	9	of	of	IN
cord-006788-kz8i4a6h	21	10	regulatory	regulatory	JJ
cord-006788-kz8i4a6h	21	11	activities	activity	NNS
cord-006788-kz8i4a6h	21	12	driven	drive	VBN
cord-006788-kz8i4a6h	21	13	by	by	IN
cord-006788-kz8i4a6h	21	14	the	the	DT
cord-006788-kz8i4a6h	21	15	two	two	CD
cord-006788-kz8i4a6h	21	16	FGF	FGF	NNP
cord-006788-kz8i4a6h	21	17	classes	class	NNS
cord-006788-kz8i4a6h	21	18	appear	appear	VBP
cord-006788-kz8i4a6h	21	19	to	to	TO
cord-006788-kz8i4a6h	21	20	be	be	VB
cord-006788-kz8i4a6h	21	21	spatially	spatially	RB
cord-006788-kz8i4a6h	21	22	and	and	CC
cord-006788-kz8i4a6h	21	23	temporally	temporally	RB
cord-006788-kz8i4a6h	21	24	segregated	segregate	VBN
cord-006788-kz8i4a6h	21	25	.	.	.
cord-006788-kz8i4a6h	22	1	At	at	IN
cord-006788-kz8i4a6h	22	2	a	a	DT
cord-006788-kz8i4a6h	22	3	physiological	physiological	JJ
cord-006788-kz8i4a6h	22	4	level	level	NN
cord-006788-kz8i4a6h	22	5	,	,	,
cord-006788-kz8i4a6h	22	6	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	22	7	FGFs	fgf	NNS
cord-006788-kz8i4a6h	22	8	appear	appear	VBP
cord-006788-kz8i4a6h	22	9	to	to	TO
cord-006788-kz8i4a6h	22	10	be	be	VB
cord-006788-kz8i4a6h	22	11	incapable	incapable	JJ
cord-006788-kz8i4a6h	22	12	of	of	IN
cord-006788-kz8i4a6h	22	13	traveling	travel	VBG
cord-006788-kz8i4a6h	22	14	far	far	RB
cord-006788-kz8i4a6h	22	15	to	to	IN
cord-006788-kz8i4a6h	22	16	other	other	JJ
cord-006788-kz8i4a6h	22	17	tissues	tissue	NNS
cord-006788-kz8i4a6h	22	18	,	,	,
cord-006788-kz8i4a6h	22	19	including	include	VBG
cord-006788-kz8i4a6h	22	20	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	22	21	tissues	tissue	NNS
cord-006788-kz8i4a6h	22	22	,	,	,
cord-006788-kz8i4a6h	22	23	to	to	TO
cord-006788-kz8i4a6h	22	24	promote	promote	VB
cord-006788-kz8i4a6h	22	25	cellular	cellular	JJ
cord-006788-kz8i4a6h	22	26	metabolism	metabolism	NN
cord-006788-kz8i4a6h	22	27	because	because	IN
cord-006788-kz8i4a6h	22	28	of	of	IN
cord-006788-kz8i4a6h	22	29	local	local	JJ
cord-006788-kz8i4a6h	22	30	trapping	trapping	NN
cord-006788-kz8i4a6h	22	31	after	after	IN
cord-006788-kz8i4a6h	22	32	secretion	secretion	NN
cord-006788-kz8i4a6h	22	33	that	that	WDT
cord-006788-kz8i4a6h	22	34	is	be	VBZ
cord-006788-kz8i4a6h	22	35	mediated	mediate	VBN
cord-006788-kz8i4a6h	22	36	by	by	IN
cord-006788-kz8i4a6h	22	37	high	high	JJ
cord-006788-kz8i4a6h	22	38	affinity	affinity	NN
cord-006788-kz8i4a6h	22	39	binding	bind	VBG
cord-006788-kz8i4a6h	22	40	to	to	IN
cord-006788-kz8i4a6h	22	41	the	the	DT
cord-006788-kz8i4a6h	22	42	extracellular	extracellular	JJ
cord-006788-kz8i4a6h	22	43	matrix	matrix	NN
cord-006788-kz8i4a6h	22	44	heparan	heparan	NN
cord-006788-kz8i4a6h	22	45	sulfate	sulfate	NN
cord-006788-kz8i4a6h	22	46	(	(	-LRB-
cord-006788-kz8i4a6h	22	47	HS	HS	NNP
cord-006788-kz8i4a6h	22	48	)	)	-RRB-
cord-006788-kz8i4a6h	22	49	.	.	.
cord-006788-kz8i4a6h	23	1	On	on	IN
cord-006788-kz8i4a6h	23	2	the	the	DT
cord-006788-kz8i4a6h	23	3	other	other	JJ
cord-006788-kz8i4a6h	23	4	hand	hand	NN
cord-006788-kz8i4a6h	23	5	,	,	,
cord-006788-kz8i4a6h	23	6	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	23	7	FGFs	fgf	NNS
cord-006788-kz8i4a6h	23	8	circulate	circulate	VBP
cord-006788-kz8i4a6h	23	9	but	but	CC
cord-006788-kz8i4a6h	23	10	are	be	VBP
cord-006788-kz8i4a6h	23	11	inactive	inactive	JJ
cord-006788-kz8i4a6h	23	12	for	for	IN
cord-006788-kz8i4a6h	23	13	nonmetabolic	nonmetabolic	JJ
cord-006788-kz8i4a6h	23	14	tissues	tissue	NNS
cord-006788-kz8i4a6h	23	15	or	or	CC
cord-006788-kz8i4a6h	23	16	cells	cell	NNS
cord-006788-kz8i4a6h	23	17	that	that	WDT
cord-006788-kz8i4a6h	23	18	often	often	RB
cord-006788-kz8i4a6h	23	19	undergo	undergo	VBP
cord-006788-kz8i4a6h	23	20	active	active	JJ
cord-006788-kz8i4a6h	23	21	tissue	tissue	NN
cord-006788-kz8i4a6h	23	22	remodeling	remodeling	NN
cord-006788-kz8i4a6h	23	23	via	via	IN
cord-006788-kz8i4a6h	23	24	the	the	DT
cord-006788-kz8i4a6h	23	25	renewed	renew	VBN
cord-006788-kz8i4a6h	23	26	cycles	cycle	NNS
cord-006788-kz8i4a6h	23	27	of	of	IN
cord-006788-kz8i4a6h	23	28	cell	cell	NN
cord-006788-kz8i4a6h	23	29	proliferation	proliferation	NN
cord-006788-kz8i4a6h	23	30	and	and	CC
cord-006788-kz8i4a6h	23	31	population	population	NN
cord-006788-kz8i4a6h	23	32	growth	growth	NN
cord-006788-kz8i4a6h	23	33	because	because	IN
cord-006788-kz8i4a6h	23	34	of	of	IN
cord-006788-kz8i4a6h	23	35	the	the	DT
cord-006788-kz8i4a6h	23	36	lack	lack	NN
cord-006788-kz8i4a6h	23	37	of	of	IN
cord-006788-kz8i4a6h	23	38	critical	critical	JJ
cord-006788-kz8i4a6h	23	39	transmembrane	transmembrane	NN
cord-006788-kz8i4a6h	23	40	accessory	accessory	NN
cord-006788-kz8i4a6h	23	41	coreceptors	coreceptor	NNS
cord-006788-kz8i4a6h	23	42	.	.	.
cord-006788-kz8i4a6h	24	1	This	this	DT
cord-006788-kz8i4a6h	24	2	divergence	divergence	NN
cord-006788-kz8i4a6h	24	3	necessitates	necessitate	VBZ
cord-006788-kz8i4a6h	24	4	a	a	DT
cord-006788-kz8i4a6h	24	5	distinction	distinction	NN
cord-006788-kz8i4a6h	24	6	of	of	IN
cord-006788-kz8i4a6h	24	7	the	the	DT
cord-006788-kz8i4a6h	24	8	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	24	9	axis	axis	NN
cord-006788-kz8i4a6h	24	10	that	that	WDT
cord-006788-kz8i4a6h	24	11	is	be	VBZ
cord-006788-kz8i4a6h	24	12	a	a	DT
cord-006788-kz8i4a6h	24	13	term	term	NN
cord-006788-kz8i4a6h	24	14	as	as	IN
cord-006788-kz8i4a6h	24	15	we	-PRON-	PRP
cord-006788-kz8i4a6h	24	16	call	call	VBP
cord-006788-kz8i4a6h	24	17	hereafter	hereafter	RB
cord-006788-kz8i4a6h	24	18	,	,	,
cord-006788-kz8i4a6h	24	19	which	which	WDT
cord-006788-kz8i4a6h	24	20	the	the	DT
cord-006788-kz8i4a6h	24	21	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	24	22	FGFs	fgf	NNS
cord-006788-kz8i4a6h	24	23	drive	drive	NN
cord-006788-kz8i4a6h	24	24	,	,	,
cord-006788-kz8i4a6h	24	25	from	from	IN
cord-006788-kz8i4a6h	24	26	the	the	DT
cord-006788-kz8i4a6h	24	27	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	24	28	axis	axis	NN
cord-006788-kz8i4a6h	24	29	that	that	WDT
cord-006788-kz8i4a6h	24	30	the	the	DT
cord-006788-kz8i4a6h	24	31	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	24	32	FGFs	FGFs	NNPS
cord-006788-kz8i4a6h	24	33	drive	drive	NN
cord-006788-kz8i4a6h	24	34	.	.	.
cord-006788-kz8i4a6h	25	1	The	the	DT
cord-006788-kz8i4a6h	25	2	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	25	3	axis	axis	NN
cord-006788-kz8i4a6h	25	4	still	still	RB
cord-006788-kz8i4a6h	25	5	shares	share	VBZ
cord-006788-kz8i4a6h	25	6	the	the	DT
cord-006788-kz8i4a6h	25	7	major	major	JJ
cord-006788-kz8i4a6h	25	8	aspects	aspect	NNS
cord-006788-kz8i4a6h	25	9	of	of	IN
cord-006788-kz8i4a6h	25	10	structural	structural	JJ
cord-006788-kz8i4a6h	25	11	coevolution	coevolution	NN
cord-006788-kz8i4a6h	25	12	[	[	-LRB-
cord-006788-kz8i4a6h	25	13	9,10	9,10	CD
cord-006788-kz8i4a6h	25	14	]	]	-RRB-
cord-006788-kz8i4a6h	25	15	while	while	IN
cord-006788-kz8i4a6h	25	16	gaining	gain	VBG
cord-006788-kz8i4a6h	25	17	unique	unique	JJ
cord-006788-kz8i4a6h	25	18	structural	structural	JJ
cord-006788-kz8i4a6h	25	19	and	and	CC
cord-006788-kz8i4a6h	25	20	functional	functional	JJ
cord-006788-kz8i4a6h	25	21	divergence	divergence	NN
cord-006788-kz8i4a6h	25	22	with	with	IN
cord-006788-kz8i4a6h	25	23	the	the	DT
cord-006788-kz8i4a6h	25	24	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	25	25	axis	axis	NN
cord-006788-kz8i4a6h	25	26	within	within	IN
cord-006788-kz8i4a6h	25	27	each	each	DT
cord-006788-kz8i4a6h	25	28	subfamily	subfamily	NN
cord-006788-kz8i4a6h	25	29	(	(	-LRB-
cord-006788-kz8i4a6h	25	30	Table	table	NN
cord-006788-kz8i4a6h	25	31	1	1	CD
cord-006788-kz8i4a6h	25	32	)	)	-RRB-
cord-006788-kz8i4a6h	25	33	,	,	,
cord-006788-kz8i4a6h	25	34	as	as	IN
cord-006788-kz8i4a6h	25	35	our	-PRON-	PRP$
cord-006788-kz8i4a6h	25	36	recent	recent	JJ
cord-006788-kz8i4a6h	25	37	structural	structural	JJ
cord-006788-kz8i4a6h	25	38	studies	study	NNS
cord-006788-kz8i4a6h	25	39	have	have	VBP
cord-006788-kz8i4a6h	25	40	revealed	reveal	VBN
cord-006788-kz8i4a6h	25	41	[	[	-LRB-
cord-006788-kz8i4a6h	25	42	2	2	CD
cord-006788-kz8i4a6h	25	43	,	,	,
cord-006788-kz8i4a6h	25	44	5	5	CD
cord-006788-kz8i4a6h	25	45	,	,	,
cord-006788-kz8i4a6h	25	46	11	11	CD
cord-006788-kz8i4a6h	25	47	]	]	-RRB-
cord-006788-kz8i4a6h	25	48	.	.	.
cord-006788-kz8i4a6h	26	1	From	from	IN
cord-006788-kz8i4a6h	26	2	the	the	DT
cord-006788-kz8i4a6h	26	3	evolutionary	evolutionary	JJ
cord-006788-kz8i4a6h	26	4	standpoint	standpoint	NN
cord-006788-kz8i4a6h	26	5	,	,	,
cord-006788-kz8i4a6h	26	6	although	although	IN
cord-006788-kz8i4a6h	26	7	the	the	DT
cord-006788-kz8i4a6h	26	8	two	two	CD
cord-006788-kz8i4a6h	26	9	axes	axis	NNS
cord-006788-kz8i4a6h	26	10	largely	largely	RB
cord-006788-kz8i4a6h	26	11	parallel	parallel	VBP
cord-006788-kz8i4a6h	26	12	and	and	CC
cord-006788-kz8i4a6h	26	13	drive	drive	VB
cord-006788-kz8i4a6h	26	14	differential	differential	JJ
cord-006788-kz8i4a6h	26	15	effects	effect	NNS
cord-006788-kz8i4a6h	26	16	via	via	IN
cord-006788-kz8i4a6h	26	17	divergent	divergent	JJ
cord-006788-kz8i4a6h	26	18	intracellular	intracellular	JJ
cord-006788-kz8i4a6h	26	19	mechanisms	mechanism	NNS
cord-006788-kz8i4a6h	26	20	,	,	,
cord-006788-kz8i4a6h	26	21	they	-PRON-	PRP
cord-006788-kz8i4a6h	26	22	aim	aim	VBP
cord-006788-kz8i4a6h	26	23	for	for	IN
cord-006788-kz8i4a6h	26	24	a	a	DT
cord-006788-kz8i4a6h	26	25	common	common	JJ
cord-006788-kz8i4a6h	26	26	goal	goal	NN
cord-006788-kz8i4a6h	26	27	of	of	IN
cord-006788-kz8i4a6h	26	28	promoting	promote	VBG
cord-006788-kz8i4a6h	26	29	the	the	DT
cord-006788-kz8i4a6h	26	30	survival	survival	NN
cord-006788-kz8i4a6h	26	31	and	and	CC
cord-006788-kz8i4a6h	26	32	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	26	33	of	of	IN
cord-006788-kz8i4a6h	26	34	each	each	DT
cord-006788-kz8i4a6h	26	35	cell	cell	NN
cord-006788-kz8i4a6h	26	36	/	/	SYM
cord-006788-kz8i4a6h	26	37	tissue	tissue	NN
cord-006788-kz8i4a6h	26	38	system	system	NN
cord-006788-kz8i4a6h	26	39	and	and	CC
cord-006788-kz8i4a6h	26	40	the	the	DT
cord-006788-kz8i4a6h	26	41	organism	organism	NN
cord-006788-kz8i4a6h	26	42	as	as	IN
cord-006788-kz8i4a6h	26	43	a	a	DT
cord-006788-kz8i4a6h	26	44	whole	whole	NN
cord-006788-kz8i4a6h	26	45	(	(	-LRB-
cord-006788-kz8i4a6h	26	46	Fig	Fig	NNP
cord-006788-kz8i4a6h	26	47	.	.	.
cord-006788-kz8i4a6h	26	48	1	1	CD
cord-006788-kz8i4a6h	26	49	)	)	-RRB-
cord-006788-kz8i4a6h	26	50	,	,	,
cord-006788-kz8i4a6h	26	51	as	as	IN
cord-006788-kz8i4a6h	26	52	we	-PRON-	PRP
cord-006788-kz8i4a6h	26	53	have	have	VBP
cord-006788-kz8i4a6h	26	54	summarized	summarize	VBN
cord-006788-kz8i4a6h	26	55	in	in	IN
cord-006788-kz8i4a6h	26	56	a	a	DT
cord-006788-kz8i4a6h	26	57	previous	previous	JJ
cord-006788-kz8i4a6h	26	58	review	review	NN
cord-006788-kz8i4a6h	26	59	[	[	-LRB-
cord-006788-kz8i4a6h	26	60	7	7	CD
cord-006788-kz8i4a6h	26	61	]	]	-RRB-
cord-006788-kz8i4a6h	26	62	.	.	.
cord-006788-kz8i4a6h	27	1	The	the	DT
cord-006788-kz8i4a6h	27	2	classic	classic	JJ
cord-006788-kz8i4a6h	27	3	FGF	FGF	NNP
cord-006788-kz8i4a6h	27	4	family	family	NN
cord-006788-kz8i4a6h	27	5	consists	consist	VBZ
cord-006788-kz8i4a6h	27	6	of	of	IN
cord-006788-kz8i4a6h	27	7	17	17	CD
cord-006788-kz8i4a6h	27	8	structurally	structurally	RB
cord-006788-kz8i4a6h	27	9	related	relate	VBN
cord-006788-kz8i4a6h	27	10	polypeptides	polypeptide	NNS
cord-006788-kz8i4a6h	27	11	,	,	,
cord-006788-kz8i4a6h	27	12	which	which	WDT
cord-006788-kz8i4a6h	27	13	are	be	VBP
cord-006788-kz8i4a6h	27	14	secreted	secrete	VBN
cord-006788-kz8i4a6h	27	15	and	and	CC
cord-006788-kz8i4a6h	27	16	act	act	VB
cord-006788-kz8i4a6h	27	17	as	as	IN
cord-006788-kz8i4a6h	27	18	extracellular	extracellular	JJ
cord-006788-kz8i4a6h	27	19	signaling	signal	VBG
cord-006788-kz8i4a6h	27	20	molecules	molecule	NNS
cord-006788-kz8i4a6h	27	21	,	,	,
cord-006788-kz8i4a6h	27	22	in	in	IN
cord-006788-kz8i4a6h	27	23	humans	human	NNS
cord-006788-kz8i4a6h	27	24	[	[	-LRB-
cord-006788-kz8i4a6h	27	25	1	1	CD
cord-006788-kz8i4a6h	27	26	,	,	,
cord-006788-kz8i4a6h	27	27	3	3	CD
cord-006788-kz8i4a6h	27	28	,	,	,
cord-006788-kz8i4a6h	27	29	7	7	CD
cord-006788-kz8i4a6h	27	30	,	,	,
cord-006788-kz8i4a6h	27	31	12	12	CD
cord-006788-kz8i4a6h	27	32	]	]	-RRB-
cord-006788-kz8i4a6h	27	33	.	.	.
cord-006788-kz8i4a6h	28	1	For	for	IN
cord-006788-kz8i4a6h	28	2	the	the	DT
cord-006788-kz8i4a6h	28	3	most	most	JJS
cord-006788-kz8i4a6h	28	4	part	part	NN
cord-006788-kz8i4a6h	28	5	of	of	IN
cord-006788-kz8i4a6h	28	6	FGF	FGF	NNP
cord-006788-kz8i4a6h	28	7	history	history	NN
cord-006788-kz8i4a6h	28	8	beginning	begin	VBG
cord-006788-kz8i4a6h	28	9	in	in	IN
cord-006788-kz8i4a6h	28	10	the	the	DT
cord-006788-kz8i4a6h	28	11	late	late	JJ
cord-006788-kz8i4a6h	28	12	1970s	1970	NNS
cord-006788-kz8i4a6h	28	13	[	[	-LRB-
cord-006788-kz8i4a6h	28	14	13	13	CD
cord-006788-kz8i4a6h	28	15	,	,	,
cord-006788-kz8i4a6h	28	16	14	14	CD
cord-006788-kz8i4a6h	28	17	]	]	-RRB-
cord-006788-kz8i4a6h	28	18	,	,	,
cord-006788-kz8i4a6h	28	19	FGFs	fgf	NNS
cord-006788-kz8i4a6h	28	20	are	be	VBP
cord-006788-kz8i4a6h	28	21	known	know	VBN
cord-006788-kz8i4a6h	28	22	as	as	IN
cord-006788-kz8i4a6h	28	23	short	short	JJ
cord-006788-kz8i4a6h	28	24	-	-	HYPH
cord-006788-kz8i4a6h	28	25	range	range	NN
cord-006788-kz8i4a6h	28	26	mitogens	mitogen	NNS
cord-006788-kz8i4a6h	28	27	in	in	IN
cord-006788-kz8i4a6h	28	28	a	a	DT
cord-006788-kz8i4a6h	28	29	wide	wide	JJ
cord-006788-kz8i4a6h	28	30	variety	variety	NN
cord-006788-kz8i4a6h	28	31	of	of	IN
cord-006788-kz8i4a6h	28	32	cell	cell	NN
cord-006788-kz8i4a6h	28	33	types	type	NNS
cord-006788-kz8i4a6h	28	34	in	in	IN
cord-006788-kz8i4a6h	28	35	the	the	DT
cord-006788-kz8i4a6h	28	36	developing	develop	VBG
cord-006788-kz8i4a6h	28	37	ectoderm	ectoderm	NNS
cord-006788-kz8i4a6h	28	38	,	,	,
cord-006788-kz8i4a6h	28	39	mesoderm	mesoderm	NNS
cord-006788-kz8i4a6h	28	40	,	,	,
cord-006788-kz8i4a6h	28	41	and	and	CC
cord-006788-kz8i4a6h	28	42	endoderm	endoderm	NNS
cord-006788-kz8i4a6h	28	43	.	.	.
cord-006788-kz8i4a6h	29	1	FGFs	fgf	NNS
cord-006788-kz8i4a6h	29	2	elicit	elicit	VBP
cord-006788-kz8i4a6h	29	3	a	a	DT
cord-006788-kz8i4a6h	29	4	chemoattractant	chemoattractant	JJ
cord-006788-kz8i4a6h	29	5	activity	activity	NN
cord-006788-kz8i4a6h	29	6	to	to	TO
cord-006788-kz8i4a6h	29	7	promote	promote	VB
cord-006788-kz8i4a6h	29	8	cell	cell	NN
cord-006788-kz8i4a6h	29	9	migration	migration	NN
cord-006788-kz8i4a6h	29	10	and	and	CC
cord-006788-kz8i4a6h	29	11	tissue	tissue	NN
cord-006788-kz8i4a6h	29	12	remodeling	remodeling	NN
cord-006788-kz8i4a6h	29	13	and	and	CC
cord-006788-kz8i4a6h	29	14	antiapoptotic	antiapoptotic	JJ
cord-006788-kz8i4a6h	29	15	effects	effect	NNS
cord-006788-kz8i4a6h	29	16	to	to	TO
cord-006788-kz8i4a6h	29	17	promote	promote	VB
cord-006788-kz8i4a6h	29	18	cell	cell	NN
cord-006788-kz8i4a6h	29	19	survival	survival	NN
cord-006788-kz8i4a6h	29	20	.	.	.
cord-006788-kz8i4a6h	30	1	FGF1	FGF1	NNP
cord-006788-kz8i4a6h	30	2	and	and	CC
cord-006788-kz8i4a6h	30	3	2	2	CD
cord-006788-kz8i4a6h	30	4	are	be	VBP
cord-006788-kz8i4a6h	30	5	the	the	DT
cord-006788-kz8i4a6h	30	6	prototypes	prototype	NNS
cord-006788-kz8i4a6h	30	7	that	that	WDT
cord-006788-kz8i4a6h	30	8	are	be	VBP
cord-006788-kz8i4a6h	30	9	initially	initially	RB
cord-006788-kz8i4a6h	30	10	isolated	isolate	VBN
cord-006788-kz8i4a6h	30	11	based	base	VBN
cord-006788-kz8i4a6h	30	12	on	on	IN
cord-006788-kz8i4a6h	30	13	potent	potent	JJ
cord-006788-kz8i4a6h	30	14	mitogenic	mitogenic	JJ
cord-006788-kz8i4a6h	30	15	activity	activity	NN
cord-006788-kz8i4a6h	30	16	toward	toward	IN
cord-006788-kz8i4a6h	30	17	fibroblasts	fibroblast	NNS
cord-006788-kz8i4a6h	30	18	or	or	CC
cord-006788-kz8i4a6h	30	19	fibroblastlike	fibroblastlike	JJ
cord-006788-kz8i4a6h	30	20	cells	cell	NNS
cord-006788-kz8i4a6h	30	21	[	[	-LRB-
cord-006788-kz8i4a6h	30	22	13	13	CD
cord-006788-kz8i4a6h	30	23	,	,	,
cord-006788-kz8i4a6h	30	24	14	14	CD
cord-006788-kz8i4a6h	30	25	]	]	-RRB-
cord-006788-kz8i4a6h	30	26	.	.	.
cord-006788-kz8i4a6h	31	1	It	-PRON-	PRP
cord-006788-kz8i4a6h	31	2	was	be	VBD
cord-006788-kz8i4a6h	31	3	found	find	VBN
cord-006788-kz8i4a6h	31	4	early	early	RB
cord-006788-kz8i4a6h	31	5	that	that	IN
cord-006788-kz8i4a6h	31	6	the	the	DT
cord-006788-kz8i4a6h	31	7	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	31	8	FGFs	fgf	NNS
cord-006788-kz8i4a6h	31	9	bind	bind	VBP
cord-006788-kz8i4a6h	31	10	tightly	tightly	RB
cord-006788-kz8i4a6h	31	11	to	to	IN
cord-006788-kz8i4a6h	31	12	the	the	DT
cord-006788-kz8i4a6h	31	13	local	local	JJ
cord-006788-kz8i4a6h	31	14	extracellular	extracellular	JJ
cord-006788-kz8i4a6h	31	15	matrix	matrix	NN
cord-006788-kz8i4a6h	31	16	HS	HS	NNP
cord-006788-kz8i4a6h	31	17	chains	chain	NNS
cord-006788-kz8i4a6h	31	18	,	,	,
cord-006788-kz8i4a6h	31	19	do	do	VBP
cord-006788-kz8i4a6h	31	20	not	not	RB
cord-006788-kz8i4a6h	31	21	circulate	circulate	VB
cord-006788-kz8i4a6h	31	22	,	,	,
cord-006788-kz8i4a6h	31	23	and	and	CC
cord-006788-kz8i4a6h	31	24	accordingly	accordingly	RB
cord-006788-kz8i4a6h	31	25	act	act	VB
cord-006788-kz8i4a6h	31	26	in	in	IN
cord-006788-kz8i4a6h	31	27	a	a	DT
cord-006788-kz8i4a6h	31	28	paracrine	paracrine	NN
cord-006788-kz8i4a6h	31	29	or	or	CC
cord-006788-kz8i4a6h	31	30	autocrine	autocrine	NN
cord-006788-kz8i4a6h	31	31	mode	mode	NN
cord-006788-kz8i4a6h	31	32	.	.	.
cord-006788-kz8i4a6h	32	1	This	this	DT
cord-006788-kz8i4a6h	32	2	heparin	heparin	NN
cord-006788-kz8i4a6h	32	3	/	/	SYM
cord-006788-kz8i4a6h	32	4	HS	HS	NNP
cord-006788-kz8i4a6h	32	5	binding	bind	VBG
cord-006788-kz8i4a6h	32	6	property	property	NN
cord-006788-kz8i4a6h	32	7	renders	render	VBZ
cord-006788-kz8i4a6h	32	8	their	-PRON-	PRP$
cord-006788-kz8i4a6h	32	9	potent	potent	JJ
cord-006788-kz8i4a6h	32	10	activity	activity	NN
cord-006788-kz8i4a6h	32	11	temporarily	temporarily	RB
cord-006788-kz8i4a6h	32	12	contained	contain	VBD
cord-006788-kz8i4a6h	32	13	but	but	CC
cord-006788-kz8i4a6h	32	14	timely	timely	RB
cord-006788-kz8i4a6h	32	15	released	release	VBN
cord-006788-kz8i4a6h	32	16	locally	locally	RB
cord-006788-kz8i4a6h	32	17	upon	upon	IN
cord-006788-kz8i4a6h	32	18	injury	injury	NN
cord-006788-kz8i4a6h	32	19	or	or	CC
cord-006788-kz8i4a6h	32	20	demand	demand	NN
cord-006788-kz8i4a6h	32	21	of	of	IN
cord-006788-kz8i4a6h	32	22	tissue	tissue	NN
cord-006788-kz8i4a6h	32	23	remodeling	remodel	VBG
cord-006788-kz8i4a6h	32	24	[	[	-LRB-
cord-006788-kz8i4a6h	32	25	15	15	CD
cord-006788-kz8i4a6h	32	26	]	]	-RRB-
cord-006788-kz8i4a6h	32	27	.	.	.
cord-006788-kz8i4a6h	33	1	These	these	DT
cord-006788-kz8i4a6h	33	2	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	33	3	FGFs	fgf	NNS
cord-006788-kz8i4a6h	33	4	include	include	VBP
cord-006788-kz8i4a6h	33	5	14	14	CD
cord-006788-kz8i4a6h	33	6	members	member	NNS
cord-006788-kz8i4a6h	33	7	(	(	-LRB-
cord-006788-kz8i4a6h	33	8	Table	table	NN
cord-006788-kz8i4a6h	33	9	1	1	CD
cord-006788-kz8i4a6h	33	10	)	)	-RRB-
cord-006788-kz8i4a6h	33	11	,	,	,
cord-006788-kz8i4a6h	33	12	which	which	WDT
cord-006788-kz8i4a6h	33	13	strongly	strongly	RB
cord-006788-kz8i4a6h	33	14	promote	promote	VBP
cord-006788-kz8i4a6h	33	15	genomic	genomic	JJ
cord-006788-kz8i4a6h	33	16	DNA	dna	NN
cord-006788-kz8i4a6h	33	17	synthesis	synthesis	NN
cord-006788-kz8i4a6h	33	18	and	and	CC
cord-006788-kz8i4a6h	33	19	subsequent	subsequent	JJ
cord-006788-kz8i4a6h	33	20	cell	cell	NN
cord-006788-kz8i4a6h	33	21	division	division	NN
cord-006788-kz8i4a6h	33	22	and	and	CC
cord-006788-kz8i4a6h	33	23	population	population	NN
cord-006788-kz8i4a6h	33	24	growth	growth	NN
cord-006788-kz8i4a6h	33	25	[	[	-LRB-
cord-006788-kz8i4a6h	33	26	12	12	CD
cord-006788-kz8i4a6h	33	27	,	,	,
cord-006788-kz8i4a6h	33	28	16	16	CD
cord-006788-kz8i4a6h	33	29	,	,	,
cord-006788-kz8i4a6h	33	30	17	17	CD
cord-006788-kz8i4a6h	33	31	]	]	-RRB-
cord-006788-kz8i4a6h	33	32	.	.	.
cord-006788-kz8i4a6h	34	1	Therefore	therefore	RB
cord-006788-kz8i4a6h	34	2	,	,	,
cord-006788-kz8i4a6h	34	3	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	34	4	FGFs	fgf	NNS
cord-006788-kz8i4a6h	34	5	play	play	VBP
cord-006788-kz8i4a6h	34	6	critical	critical	JJ
cord-006788-kz8i4a6h	34	7	roles	role	NNS
cord-006788-kz8i4a6h	34	8	in	in	IN
cord-006788-kz8i4a6h	34	9	the	the	DT
cord-006788-kz8i4a6h	34	10	development	development	NN
cord-006788-kz8i4a6h	34	11	of	of	IN
cord-006788-kz8i4a6h	34	12	multiple	multiple	JJ
cord-006788-kz8i4a6h	34	13	tissues	tissue	NNS
cord-006788-kz8i4a6h	34	14	/	/	SYM
cord-006788-kz8i4a6h	34	15	organs	organ	NNS
cord-006788-kz8i4a6h	34	16	[	[	-LRB-
cord-006788-kz8i4a6h	34	17	18	18	CD
cord-006788-kz8i4a6h	34	18	]	]	-RRB-
cord-006788-kz8i4a6h	34	19	[	[	-LRB-
cord-006788-kz8i4a6h	34	20	19	19	CD
cord-006788-kz8i4a6h	34	21	]	]	-RRB-
cord-006788-kz8i4a6h	34	22	[	[	-LRB-
cord-006788-kz8i4a6h	34	23	20	20	CD
cord-006788-kz8i4a6h	34	24	]	]	-RRB-
cord-006788-kz8i4a6h	34	25	.	.	.
cord-006788-kz8i4a6h	35	1	They	-PRON-	PRP
cord-006788-kz8i4a6h	35	2	initiate	initiate	VBP
cord-006788-kz8i4a6h	35	3	the	the	DT
cord-006788-kz8i4a6h	35	4	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	35	5	axis	axis	NN
cord-006788-kz8i4a6h	35	6	by	by	IN
cord-006788-kz8i4a6h	35	7	binding	bind	VBG
cord-006788-kz8i4a6h	35	8	to	to	IN
cord-006788-kz8i4a6h	35	9	the	the	DT
cord-006788-kz8i4a6h	35	10	Ig	Ig	NNP
cord-006788-kz8i4a6h	35	11	-	-	HYPH
cord-006788-kz8i4a6h	35	12	like	like	JJ
cord-006788-kz8i4a6h	35	13	ectodomains	ectodomain	NNS
cord-006788-kz8i4a6h	35	14	of	of	IN
cord-006788-kz8i4a6h	35	15	their	-PRON-	PRP$
cord-006788-kz8i4a6h	35	16	cognate	cognate	JJ
cord-006788-kz8i4a6h	35	17	transmembrane	transmembrane	NN
cord-006788-kz8i4a6h	35	18	FGFRs	fgfr	NNS
cord-006788-kz8i4a6h	35	19	in	in	IN
cord-006788-kz8i4a6h	35	20	complex	complex	NN
cord-006788-kz8i4a6h	35	21	with	with	IN
cord-006788-kz8i4a6h	35	22	HS	HS	NNP
cord-006788-kz8i4a6h	35	23	motifs	motif	NNS
cord-006788-kz8i4a6h	35	24	on	on	IN
cord-006788-kz8i4a6h	35	25	diverse	diverse	JJ
cord-006788-kz8i4a6h	35	26	target	target	NN
cord-006788-kz8i4a6h	35	27	cells	cell	NNS
cord-006788-kz8i4a6h	35	28	and	and	CC
cord-006788-kz8i4a6h	35	29	tissues	tissue	NNS
cord-006788-kz8i4a6h	35	30	in	in	IN
cord-006788-kz8i4a6h	35	31	the	the	DT
cord-006788-kz8i4a6h	35	32	first	first	JJ
cord-006788-kz8i4a6h	35	33	step	step	NN
cord-006788-kz8i4a6h	35	34	[	[	-LRB-
cord-006788-kz8i4a6h	35	35	1	1	CD
cord-006788-kz8i4a6h	35	36	,	,	,
cord-006788-kz8i4a6h	35	37	21	21	CD
cord-006788-kz8i4a6h	35	38	,	,	,
cord-006788-kz8i4a6h	35	39	22	22	CD
cord-006788-kz8i4a6h	35	40	]	]	-RRB-
cord-006788-kz8i4a6h	35	41	.	.	.
cord-006788-kz8i4a6h	36	1	The	the	DT
cord-006788-kz8i4a6h	36	2	subsequent	subsequent	JJ
cord-006788-kz8i4a6h	36	3	activation	activation	NN
cord-006788-kz8i4a6h	36	4	of	of	IN
cord-006788-kz8i4a6h	36	5	the	the	DT
cord-006788-kz8i4a6h	36	6	intracellular	intracellular	JJ
cord-006788-kz8i4a6h	36	7	kinase	kinase	NN
cord-006788-kz8i4a6h	36	8	domains	domain	NNS
cord-006788-kz8i4a6h	36	9	of	of	IN
cord-006788-kz8i4a6h	36	10	FGFRs	fgfr	NNS
cord-006788-kz8i4a6h	36	11	results	result	VBZ
cord-006788-kz8i4a6h	36	12	in	in	IN
cord-006788-kz8i4a6h	36	13	downstream	downstream	JJ
cord-006788-kz8i4a6h	36	14	signal	signal	NN
cord-006788-kz8i4a6h	36	15	relay	relay	NN
cord-006788-kz8i4a6h	36	16	primarily	primarily	RB
cord-006788-kz8i4a6h	36	17	through	through	IN
cord-006788-kz8i4a6h	36	18	the	the	DT
cord-006788-kz8i4a6h	36	19	PI3K	PI3K	NNP
cord-006788-kz8i4a6h	36	20	-	-	HYPH
cord-006788-kz8i4a6h	36	21	AKT	AKT	NNP
cord-006788-kz8i4a6h	36	22	,	,	,
cord-006788-kz8i4a6h	36	23	RAS	RAS	NNP
cord-006788-kz8i4a6h	36	24	-	-	HYPH
cord-006788-kz8i4a6h	36	25	MAPK	MAPK	NNP
cord-006788-kz8i4a6h	36	26	,	,	,
cord-006788-kz8i4a6h	36	27	and	and	CC
cord-006788-kz8i4a6h	36	28	PLCg	PLCg	NNS
cord-006788-kz8i4a6h	36	29	-	-	HYPH
cord-006788-kz8i4a6h	36	30	PKC	PKC	NNP
cord-006788-kz8i4a6h	36	31	pathways	pathway	NNS
cord-006788-kz8i4a6h	36	32	[	[	-LRB-
cord-006788-kz8i4a6h	36	33	23	23	CD
cord-006788-kz8i4a6h	36	34	]	]	-RRB-
cord-006788-kz8i4a6h	37	1	[	[	-LRB-
cord-006788-kz8i4a6h	37	2	24	24	CD
cord-006788-kz8i4a6h	37	3	]	]	-RRB-
cord-006788-kz8i4a6h	37	4	[	[	-LRB-
cord-006788-kz8i4a6h	37	5	25	25	CD
cord-006788-kz8i4a6h	37	6	]	]	-RRB-
cord-006788-kz8i4a6h	37	7	,	,	,
cord-006788-kz8i4a6h	37	8	as	as	IN
cord-006788-kz8i4a6h	37	9	we	-PRON-	PRP
cord-006788-kz8i4a6h	37	10	have	have	VBP
cord-006788-kz8i4a6h	37	11	summarized	summarize	VBN
cord-006788-kz8i4a6h	37	12	previously	previously	RB
cord-006788-kz8i4a6h	37	13	[	[	-LRB-
cord-006788-kz8i4a6h	37	14	3	3	CD
cord-006788-kz8i4a6h	37	15	]	]	-RRB-
cord-006788-kz8i4a6h	37	16	.	.	.
cord-006788-kz8i4a6h	38	1	These	these	DT
cord-006788-kz8i4a6h	38	2	HS	HS	NNP
cord-006788-kz8i4a6h	38	3	and	and	CC
cord-006788-kz8i4a6h	38	4	FGFR	FGFR	NNP
cord-006788-kz8i4a6h	38	5	dependent	dependent	JJ
cord-006788-kz8i4a6h	38	6	activities	activity	NNS
cord-006788-kz8i4a6h	38	7	driven	drive	VBN
cord-006788-kz8i4a6h	38	8	by	by	IN
cord-006788-kz8i4a6h	38	9	the	the	DT
cord-006788-kz8i4a6h	38	10	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	38	11	FGF	FGF	NNP
cord-006788-kz8i4a6h	38	12	axes	axis	NNS
cord-006788-kz8i4a6h	38	13	contribute	contribute	VBP
cord-006788-kz8i4a6h	38	14	not	not	RB
cord-006788-kz8i4a6h	38	15	only	only	RB
cord-006788-kz8i4a6h	38	16	to	to	IN
cord-006788-kz8i4a6h	38	17	the	the	DT
cord-006788-kz8i4a6h	38	18	regulation	regulation	NN
cord-006788-kz8i4a6h	38	19	of	of	IN
cord-006788-kz8i4a6h	38	20	virtually	virtually	RB
cord-006788-kz8i4a6h	38	21	all	all	DT
cord-006788-kz8i4a6h	38	22	aspects	aspect	NNS
cord-006788-kz8i4a6h	38	23	of	of	IN
cord-006788-kz8i4a6h	38	24	development	development	NN
cord-006788-kz8i4a6h	38	25	and	and	CC
cord-006788-kz8i4a6h	38	26	organogenesis	organogenesi	NNS
cord-006788-kz8i4a6h	38	27	but	but	CC
cord-006788-kz8i4a6h	38	28	also	also	RB
cord-006788-kz8i4a6h	38	29	to	to	IN
cord-006788-kz8i4a6h	38	30	many	many	JJ
cord-006788-kz8i4a6h	38	31	natural	natural	JJ
cord-006788-kz8i4a6h	38	32	processes	process	NNS
cord-006788-kz8i4a6h	38	33	of	of	IN
cord-006788-kz8i4a6h	38	34	active	active	JJ
cord-006788-kz8i4a6h	38	35	post	post	JJ
cord-006788-kz8i4a6h	38	36	-	-	JJ
cord-006788-kz8i4a6h	38	37	developmental	developmental	JJ
cord-006788-kz8i4a6h	38	38	tissue	tissue	NN
cord-006788-kz8i4a6h	38	39	repair	repair	NN
cord-006788-kz8i4a6h	38	40	,	,	,
cord-006788-kz8i4a6h	38	41	remodeling	remodeling	NN
cord-006788-kz8i4a6h	38	42	,	,	,
cord-006788-kz8i4a6h	38	43	and	and	CC
cord-006788-kz8i4a6h	38	44	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	38	45	[	[	-LRB-
cord-006788-kz8i4a6h	38	46	26	26	CD
cord-006788-kz8i4a6h	38	47	]	]	-RRB-
cord-006788-kz8i4a6h	38	48	.	.	.
cord-006788-kz8i4a6h	39	1	Among	among	IN
cord-006788-kz8i4a6h	39	2	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	39	3	FGFs	FGFs	NNP
cord-006788-kz8i4a6h	39	4	,	,	,
cord-006788-kz8i4a6h	39	5	FGF7	FGF7	NNP
cord-006788-kz8i4a6h	39	6	,	,	,
cord-006788-kz8i4a6h	39	7	which	which	WDT
cord-006788-kz8i4a6h	39	8	is	be	VBZ
cord-006788-kz8i4a6h	39	9	also	also	RB
cord-006788-kz8i4a6h	39	10	known	know	VBN
cord-006788-kz8i4a6h	39	11	as	as	IN
cord-006788-kz8i4a6h	39	12	keratinocyte	keratinocyte	JJ
cord-006788-kz8i4a6h	39	13	growth	growth	NN
cord-006788-kz8i4a6h	39	14	factor	factor	NN
cord-006788-kz8i4a6h	39	15	(	(	-LRB-
cord-006788-kz8i4a6h	39	16	KGF	KGF	NNP
cord-006788-kz8i4a6h	39	17	)	)	-RRB-
cord-006788-kz8i4a6h	39	18	,	,	,
cord-006788-kz8i4a6h	39	19	has	have	VBZ
cord-006788-kz8i4a6h	39	20	the	the	DT
cord-006788-kz8i4a6h	39	21	highest	high	JJS
cord-006788-kz8i4a6h	39	22	specificity	specificity	NN
cord-006788-kz8i4a6h	39	23	for	for	IN
cord-006788-kz8i4a6h	39	24	receptor	receptor	NN
cord-006788-kz8i4a6h	39	25	isotypes	isotypes	NNP
cord-006788-kz8i4a6h	39	26	[	[	-LRB-
cord-006788-kz8i4a6h	39	27	12	12	CD
cord-006788-kz8i4a6h	39	28	,	,	,
cord-006788-kz8i4a6h	39	29	22	22	CD
cord-006788-kz8i4a6h	39	30	,	,	,
cord-006788-kz8i4a6h	39	31	27	27	CD
cord-006788-kz8i4a6h	39	32	]	]	-RRB-
cord-006788-kz8i4a6h	39	33	.	.	.
cord-006788-kz8i4a6h	40	1	FGF7	FGF7	NNP
cord-006788-kz8i4a6h	40	2	only	only	RB
cord-006788-kz8i4a6h	40	3	activates	activate	VBZ
cord-006788-kz8i4a6h	40	4	the	the	DT
cord-006788-kz8i4a6h	40	5	IIIb	iiib	JJ
cord-006788-kz8i4a6h	40	6	-	-	HYPH
cord-006788-kz8i4a6h	40	7	type	type	NN
cord-006788-kz8i4a6h	40	8	isoform	isoform	NN
cord-006788-kz8i4a6h	40	9	of	of	IN
cord-006788-kz8i4a6h	40	10	FGFR2	fgfr2	NN
cord-006788-kz8i4a6h	40	11	.	.	.
cord-006788-kz8i4a6h	41	1	Given	give	VBN
cord-006788-kz8i4a6h	41	2	that	that	IN
cord-006788-kz8i4a6h	41	3	FGF7	FGF7	NNP
cord-006788-kz8i4a6h	41	4	is	be	VBZ
cord-006788-kz8i4a6h	41	5	produced	produce	VBN
cord-006788-kz8i4a6h	41	6	in	in	IN
cord-006788-kz8i4a6h	41	7	mesenchyme	mesenchyme	NNS
cord-006788-kz8i4a6h	41	8	cells	cell	NNS
cord-006788-kz8i4a6h	41	9	,	,	,
cord-006788-kz8i4a6h	41	10	while	while	IN
cord-006788-kz8i4a6h	41	11	FGFR2IIIb	FGFR2IIIb	NNP
cord-006788-kz8i4a6h	41	12	resides	reside	VBZ
cord-006788-kz8i4a6h	41	13	on	on	IN
cord-006788-kz8i4a6h	41	14	the	the	DT
cord-006788-kz8i4a6h	41	15	epithelial	epithelial	JJ
cord-006788-kz8i4a6h	41	16	or	or	CC
cord-006788-kz8i4a6h	41	17	keratinocyte	keratinocyte	NN
cord-006788-kz8i4a6h	41	18	cells	cell	NNS
cord-006788-kz8i4a6h	41	19	,	,	,
cord-006788-kz8i4a6h	41	20	FGF7	FGF7	NNP
cord-006788-kz8i4a6h	41	21	forms	form	VBZ
cord-006788-kz8i4a6h	41	22	a	a	DT
cord-006788-kz8i4a6h	41	23	unidirectional	unidirectional	JJ
cord-006788-kz8i4a6h	41	24	paracrine	paracrine	JJ
cord-006788-kz8i4a6h	41	25	communication	communication	NN
cord-006788-kz8i4a6h	41	26	axis	axis	NN
cord-006788-kz8i4a6h	41	27	with	with	IN
cord-006788-kz8i4a6h	41	28	FGFR2	fgfr2	NN
cord-006788-kz8i4a6h	41	29	from	from	IN
cord-006788-kz8i4a6h	41	30	mesenchyme	mesenchyme	NNS
cord-006788-kz8i4a6h	41	31	to	to	IN
cord-006788-kz8i4a6h	41	32	epithelium	epithelium	NN
cord-006788-kz8i4a6h	41	33	compartment	compartment	NN
cord-006788-kz8i4a6h	41	34	within	within	IN
cord-006788-kz8i4a6h	41	35	a	a	DT
cord-006788-kz8i4a6h	41	36	tissue	tissue	NN
cord-006788-kz8i4a6h	41	37	or	or	CC
cord-006788-kz8i4a6h	41	38	organ	organ	NN
cord-006788-kz8i4a6h	41	39	.	.	.
cord-006788-kz8i4a6h	42	1	On	on	IN
cord-006788-kz8i4a6h	42	2	the	the	DT
cord-006788-kz8i4a6h	42	3	other	other	JJ
cord-006788-kz8i4a6h	42	4	hand	hand	NN
cord-006788-kz8i4a6h	42	5	,	,	,
cord-006788-kz8i4a6h	42	6	epithelial	epithelial	JJ
cord-006788-kz8i4a6h	42	7	cells	cell	NNS
cord-006788-kz8i4a6h	42	8	secrete	secrete	VBP
cord-006788-kz8i4a6h	42	9	specific	specific	JJ
cord-006788-kz8i4a6h	42	10	FGFs	fgf	NNS
cord-006788-kz8i4a6h	42	11	(	(	-LRB-
cord-006788-kz8i4a6h	42	12	e.g.	e.g.	RB
cord-006788-kz8i4a6h	42	13	,	,	,
cord-006788-kz8i4a6h	42	14	FGF1	FGF1	NNP
cord-006788-kz8i4a6h	42	15	or	or	CC
cord-006788-kz8i4a6h	42	16	9	9	CD
cord-006788-kz8i4a6h	42	17	)	)	-RRB-
cord-006788-kz8i4a6h	42	18	,	,	,
cord-006788-kz8i4a6h	42	19	which	which	WDT
cord-006788-kz8i4a6h	42	20	then	then	RB
cord-006788-kz8i4a6h	42	21	acts	act	VBZ
cord-006788-kz8i4a6h	42	22	on	on	IN
cord-006788-kz8i4a6h	42	23	mesenchymal	mesenchymal	JJ
cord-006788-kz8i4a6h	42	24	cells	cell	NNS
cord-006788-kz8i4a6h	42	25	that	that	WDT
cord-006788-kz8i4a6h	42	26	harbor	harbor	VBP
cord-006788-kz8i4a6h	42	27	FGFR1IIIc	FGFR1IIIc	NNP
cord-006788-kz8i4a6h	42	28	within	within	IN
cord-006788-kz8i4a6h	42	29	two	two	CD
cord-006788-kz8i4a6h	42	30	compartmental	compartmental	JJ
cord-006788-kz8i4a6h	42	31	tissues	tissue	NNS
cord-006788-kz8i4a6h	42	32	.	.	.
cord-006788-kz8i4a6h	43	1	Therefore	therefore	RB
cord-006788-kz8i4a6h	43	2	,	,	,
cord-006788-kz8i4a6h	43	3	these	these	DT
cord-006788-kz8i4a6h	43	4	FGF1	FGF1	NNP
cord-006788-kz8i4a6h	43	5	and	and	CC
cord-006788-kz8i4a6h	43	6	FGF7	FGF7	NNP
cord-006788-kz8i4a6h	43	7	driven	drive	VBD
cord-006788-kz8i4a6h	43	8	mutual	mutual	JJ
cord-006788-kz8i4a6h	43	9	cell	cell	NN
cord-006788-kz8i4a6h	43	10	communication	communication	NN
cord-006788-kz8i4a6h	43	11	axes	axis	NNS
cord-006788-kz8i4a6h	43	12	are	be	VBP
cord-006788-kz8i4a6h	43	13	poised	poise	VBN
cord-006788-kz8i4a6h	43	14	to	to	TO
cord-006788-kz8i4a6h	43	15	drive	drive	VB
cord-006788-kz8i4a6h	43	16	tissue	tissue	NN
cord-006788-kz8i4a6h	43	17	remodeling	remodeling	NN
cord-006788-kz8i4a6h	43	18	and	and	CC
cord-006788-kz8i4a6h	43	19	maintain	maintain	VB
cord-006788-kz8i4a6h	43	20	tissue	tissue	NN
cord-006788-kz8i4a6h	43	21	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	43	22	[	[	-LRB-
cord-006788-kz8i4a6h	43	23	28	28	CD
cord-006788-kz8i4a6h	43	24	]	]	-RRB-
cord-006788-kz8i4a6h	43	25	.	.	.
cord-006788-kz8i4a6h	44	1	The	the	DT
cord-006788-kz8i4a6h	44	2	prolonged	prolonged	JJ
cord-006788-kz8i4a6h	44	3	or	or	CC
cord-006788-kz8i4a6h	44	4	abnormal	abnormal	JJ
cord-006788-kz8i4a6h	44	5	activation	activation	NN
cord-006788-kz8i4a6h	44	6	of	of	IN
cord-006788-kz8i4a6h	44	7	the	the	DT
cord-006788-kz8i4a6h	44	8	FGFR	FGFR	NNP
cord-006788-kz8i4a6h	44	9	-	-	HYPH
cord-006788-kz8i4a6h	44	10	HS	HS	NNP
cord-006788-kz8i4a6h	44	11	binary	binary	JJ
cord-006788-kz8i4a6h	44	12	complexes	complex	NNS
cord-006788-kz8i4a6h	44	13	by	by	IN
cord-006788-kz8i4a6h	44	14	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	44	15	FGF	FGF	NNP
cord-006788-kz8i4a6h	44	16	axes	axis	NNS
cord-006788-kz8i4a6h	44	17	contributes	contribute	VBZ
cord-006788-kz8i4a6h	44	18	to	to	IN
cord-006788-kz8i4a6h	44	19	an	an	DT
cord-006788-kz8i4a6h	44	20	array	array	NN
cord-006788-kz8i4a6h	44	21	of	of	IN
cord-006788-kz8i4a6h	44	22	cell	cell	NN
cord-006788-kz8i4a6h	44	23	/	/	SYM
cord-006788-kz8i4a6h	44	24	tissue	tissue	NN
cord-006788-kz8i4a6h	44	25	-	-	HYPH
cord-006788-kz8i4a6h	44	26	specific	specific	JJ
cord-006788-kz8i4a6h	44	27	developmental	developmental	JJ
cord-006788-kz8i4a6h	44	28	diseases	disease	NNS
cord-006788-kz8i4a6h	44	29	and	and	CC
cord-006788-kz8i4a6h	44	30	multiple	multiple	JJ
cord-006788-kz8i4a6h	44	31	cancer	cancer	NN
cord-006788-kz8i4a6h	44	32	types	type	NNS
cord-006788-kz8i4a6h	44	33	[	[	-LRB-
cord-006788-kz8i4a6h	44	34	3	3	CD
cord-006788-kz8i4a6h	44	35	,	,	,
cord-006788-kz8i4a6h	44	36	29	29	CD
cord-006788-kz8i4a6h	44	37	]	]	-RRB-
cord-006788-kz8i4a6h	44	38	(	(	-LRB-
cord-006788-kz8i4a6h	44	39	see	see	VB
cord-006788-kz8i4a6h	44	40	a	a	DT
cord-006788-kz8i4a6h	44	41	brief	brief	JJ
cord-006788-kz8i4a6h	44	42	summary	summary	NN
cord-006788-kz8i4a6h	44	43	in	in	IN
cord-006788-kz8i4a6h	44	44	Table	Table	NNP
cord-006788-kz8i4a6h	44	45	1	1	CD
cord-006788-kz8i4a6h	44	46	)	)	-RRB-
cord-006788-kz8i4a6h	44	47	.	.	.
cord-006788-kz8i4a6h	45	1	The	the	DT
cord-006788-kz8i4a6h	45	2	proliferation	proliferation	NN
cord-006788-kz8i4a6h	45	3	-	-	HYPH
cord-006788-kz8i4a6h	45	4	and	and	CC
cord-006788-kz8i4a6h	45	5	survival	survival	NN
cord-006788-kz8i4a6h	45	6	-	-	HYPH
cord-006788-kz8i4a6h	45	7	promoting	promote	VBG
cord-006788-kz8i4a6h	45	8	Fig	Fig	NNP
cord-006788-kz8i4a6h	45	9	.	.	.
cord-006788-kz8i4a6h	45	10	1	1	CD
cord-006788-kz8i4a6h	45	11	Scheme	Scheme	NNP
cord-006788-kz8i4a6h	45	12	of	of	IN
cord-006788-kz8i4a6h	45	13	FGF	FGF	NNP
cord-006788-kz8i4a6h	45	14	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	45	15	axis	axis	NN
cord-006788-kz8i4a6h	45	16	evolution	evolution	NN
cord-006788-kz8i4a6h	45	17	.	.	.
cord-006788-kz8i4a6h	46	1	The	the	DT
cord-006788-kz8i4a6h	46	2	FGF	FGF	NNP
cord-006788-kz8i4a6h	46	3	family	family	NN
cord-006788-kz8i4a6h	46	4	originates	originate	VBZ
cord-006788-kz8i4a6h	46	5	from	from	IN
cord-006788-kz8i4a6h	46	6	a	a	DT
cord-006788-kz8i4a6h	46	7	common	common	JJ
cord-006788-kz8i4a6h	46	8	FGF13-like	fgf13-like	CD
cord-006788-kz8i4a6h	46	9	ancestor	ancestor	NN
cord-006788-kz8i4a6h	46	10	molecule	molecule	NN
cord-006788-kz8i4a6h	46	11	in	in	IN
cord-006788-kz8i4a6h	46	12	early	early	JJ
cord-006788-kz8i4a6h	46	13	metazoans	metazoan	NNS
cord-006788-kz8i4a6h	46	14	that	that	WDT
cord-006788-kz8i4a6h	46	15	bifurcates	bifurcate	VBZ
cord-006788-kz8i4a6h	46	16	into	into	IN
cord-006788-kz8i4a6h	46	17	the	the	DT
cord-006788-kz8i4a6h	46	18	so	so	RB
cord-006788-kz8i4a6h	46	19	-	-	HYPH
cord-006788-kz8i4a6h	46	20	called	call	VBN
cord-006788-kz8i4a6h	46	21	intracrine	intracrine	NNP
cord-006788-kz8i4a6h	46	22	FGF	FGF	NNP
cord-006788-kz8i4a6h	46	23	-	-	HYPH
cord-006788-kz8i4a6h	46	24	homologous	homologous	JJ
cord-006788-kz8i4a6h	46	25	factor	factor	NN
cord-006788-kz8i4a6h	46	26	(	(	-LRB-
cord-006788-kz8i4a6h	46	27	FHF	FHF	NNP
cord-006788-kz8i4a6h	46	28	)	)	-RRB-
cord-006788-kz8i4a6h	46	29	subgroup	subgroup	NN
cord-006788-kz8i4a6h	46	30	(	(	-LRB-
cord-006788-kz8i4a6h	46	31	black	black	JJ
cord-006788-kz8i4a6h	46	32	arrow	arrow	NN
cord-006788-kz8i4a6h	46	33	)	)	-RRB-
cord-006788-kz8i4a6h	46	34	,	,	,
cord-006788-kz8i4a6h	46	35	including	include	VBG
cord-006788-kz8i4a6h	46	36	FGF11	FGF11	NNP
cord-006788-kz8i4a6h	46	37	,	,	,
cord-006788-kz8i4a6h	46	38	12	12	CD
cord-006788-kz8i4a6h	46	39	,	,	,
cord-006788-kz8i4a6h	46	40	13	13	CD
cord-006788-kz8i4a6h	46	41	,	,	,
cord-006788-kz8i4a6h	46	42	and	and	CC
cord-006788-kz8i4a6h	46	43	14	14	CD
cord-006788-kz8i4a6h	46	44	(	(	-LRB-
cord-006788-kz8i4a6h	46	45	not	not	RB
cord-006788-kz8i4a6h	46	46	shown	show	VBN
cord-006788-kz8i4a6h	46	47	)	)	-RRB-
cord-006788-kz8i4a6h	46	48	,	,	,
cord-006788-kz8i4a6h	46	49	and	and	CC
cord-006788-kz8i4a6h	46	50	FGF4-like	FGF4-like	NNP
cord-006788-kz8i4a6h	46	51	molecule	molecule	NN
cord-006788-kz8i4a6h	46	52	,	,	,
cord-006788-kz8i4a6h	46	53	which	which	WDT
cord-006788-kz8i4a6h	46	54	continues	continue	VBZ
cord-006788-kz8i4a6h	46	55	to	to	TO
cord-006788-kz8i4a6h	46	56	bifurcate	bifurcate	VB
cord-006788-kz8i4a6h	46	57	into	into	IN
cord-006788-kz8i4a6h	46	58	two	two	CD
cord-006788-kz8i4a6h	46	59	major	major	JJ
cord-006788-kz8i4a6h	46	60	functional	functional	JJ
cord-006788-kz8i4a6h	46	61	subgroups	subgroup	NNS
cord-006788-kz8i4a6h	46	62	with	with	IN
cord-006788-kz8i4a6h	46	63	diverging	diverge	VBG
cord-006788-kz8i4a6h	46	64	structural	structural	JJ
cord-006788-kz8i4a6h	46	65	and	and	CC
cord-006788-kz8i4a6h	46	66	functional	functional	JJ
cord-006788-kz8i4a6h	46	67	specifications	specification	NNS
cord-006788-kz8i4a6h	46	68	.	.	.
cord-006788-kz8i4a6h	47	1	The	the	DT
cord-006788-kz8i4a6h	47	2	socalled	socalled	JJ
cord-006788-kz8i4a6h	47	3	mitogenic	mitogenic	NN
cord-006788-kz8i4a6h	47	4	FGF	FGF	NNP
cord-006788-kz8i4a6h	47	5	subgroups	subgroup	NNS
cord-006788-kz8i4a6h	47	6	,	,	,
cord-006788-kz8i4a6h	47	7	including	include	VBG
cord-006788-kz8i4a6h	47	8	the	the	DT
cord-006788-kz8i4a6h	47	9	FGF5	FGF5	NNP
cord-006788-kz8i4a6h	47	10	,	,	,
cord-006788-kz8i4a6h	47	11	8	8	CD
cord-006788-kz8i4a6h	47	12	,	,	,
cord-006788-kz8i4a6h	47	13	9	9	CD
cord-006788-kz8i4a6h	47	14	,	,	,
cord-006788-kz8i4a6h	47	15	and	and	CC
cord-006788-kz8i4a6h	47	16	10	10	CD
cord-006788-kz8i4a6h	47	17	subfamilies	subfamily	NNS
cord-006788-kz8i4a6h	47	18	(	(	-LRB-
cord-006788-kz8i4a6h	47	19	red	red	JJ
cord-006788-kz8i4a6h	47	20	arrows	arrow	NNS
cord-006788-kz8i4a6h	47	21	,	,	,
cord-006788-kz8i4a6h	47	22	Table	table	NN
cord-006788-kz8i4a6h	47	23	1	1	CD
cord-006788-kz8i4a6h	47	24	)	)	-RRB-
cord-006788-kz8i4a6h	47	25	,	,	,
cord-006788-kz8i4a6h	47	26	bind	bind	VB
cord-006788-kz8i4a6h	47	27	extracellular	extracellular	JJ
cord-006788-kz8i4a6h	47	28	matrix	matrix	NN
cord-006788-kz8i4a6h	47	29	heparan	heparan	NN
cord-006788-kz8i4a6h	47	30	sulfate	sulfate	NN
cord-006788-kz8i4a6h	47	31	and	and	CC
cord-006788-kz8i4a6h	47	32	drive	drive	VB
cord-006788-kz8i4a6h	47	33	autocrine	autocrine	NN
cord-006788-kz8i4a6h	47	34	/	/	SYM
cord-006788-kz8i4a6h	47	35	paracrine	paracrine	JJ
cord-006788-kz8i4a6h	47	36	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	47	37	signal	signal	NN
cord-006788-kz8i4a6h	47	38	axes	axis	NNS
cord-006788-kz8i4a6h	47	39	to	to	TO
cord-006788-kz8i4a6h	47	40	promote	promote	VB
cord-006788-kz8i4a6h	47	41	cell	cell	NN
cord-006788-kz8i4a6h	47	42	proliferation	proliferation	NN
cord-006788-kz8i4a6h	47	43	and	and	CC
cord-006788-kz8i4a6h	47	44	population	population	NN
cord-006788-kz8i4a6h	47	45	growth	growth	NN
cord-006788-kz8i4a6h	47	46	.	.	.
cord-006788-kz8i4a6h	48	1	By	by	IN
cord-006788-kz8i4a6h	48	2	contrast	contrast	NN
cord-006788-kz8i4a6h	48	3	,	,	,
cord-006788-kz8i4a6h	48	4	the	the	DT
cord-006788-kz8i4a6h	48	5	endocrine	endocrine	JJ
cord-006788-kz8i4a6h	48	6	FGF	FGF	NNP
cord-006788-kz8i4a6h	48	7	subgroup	subgroup	NN
cord-006788-kz8i4a6h	48	8	members	member	NNS
cord-006788-kz8i4a6h	48	9	(	(	-LRB-
cord-006788-kz8i4a6h	48	10	green	green	JJ
cord-006788-kz8i4a6h	48	11	arrow	arrow	NN
cord-006788-kz8i4a6h	48	12	,	,	,
cord-006788-kz8i4a6h	48	13	Table	table	NN
cord-006788-kz8i4a6h	48	14	2	2	CD
cord-006788-kz8i4a6h	48	15	)	)	-RRB-
cord-006788-kz8i4a6h	48	16	,	,	,
cord-006788-kz8i4a6h	48	17	including	include	VBG
cord-006788-kz8i4a6h	48	18	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	48	19	,	,	,
cord-006788-kz8i4a6h	48	20	21	21	CD
cord-006788-kz8i4a6h	48	21	,	,	,
cord-006788-kz8i4a6h	48	22	and	and	CC
cord-006788-kz8i4a6h	48	23	23	23	CD
cord-006788-kz8i4a6h	48	24	,	,	,
cord-006788-kz8i4a6h	48	25	drive	drive	VB
cord-006788-kz8i4a6h	48	26	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	48	27	signal	signal	NN
cord-006788-kz8i4a6h	48	28	axes	axis	NNS
cord-006788-kz8i4a6h	48	29	that	that	WDT
cord-006788-kz8i4a6h	48	30	elicit	elicit	VBP
cord-006788-kz8i4a6h	48	31	broad	broad	JJ
cord-006788-kz8i4a6h	48	32	-	-	HYPH
cord-006788-kz8i4a6h	48	33	spectrum	spectrum	NN
cord-006788-kz8i4a6h	48	34	functions	function	NNS
cord-006788-kz8i4a6h	48	35	in	in	IN
cord-006788-kz8i4a6h	48	36	regulating	regulate	VBG
cord-006788-kz8i4a6h	48	37	the	the	DT
cord-006788-kz8i4a6h	48	38	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	48	39	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	48	40	of	of	IN
cord-006788-kz8i4a6h	48	41	bile	bile	NN
cord-006788-kz8i4a6h	48	42	acid	acid	NN
cord-006788-kz8i4a6h	48	43	,	,	,
cord-006788-kz8i4a6h	48	44	lipids	lipid	NNS
cord-006788-kz8i4a6h	48	45	,	,	,
cord-006788-kz8i4a6h	48	46	glucose	glucose	NN
cord-006788-kz8i4a6h	48	47	,	,	,
cord-006788-kz8i4a6h	48	48	energy	energy	NN
cord-006788-kz8i4a6h	48	49	,	,	,
cord-006788-kz8i4a6h	48	50	and	and	CC
cord-006788-kz8i4a6h	48	51	minerals	mineral	NNS
cord-006788-kz8i4a6h	48	52	without	without	IN
cord-006788-kz8i4a6h	48	53	direct	direct	JJ
cord-006788-kz8i4a6h	48	54	proliferation	proliferation	NN
cord-006788-kz8i4a6h	48	55	-	-	HYPH
cord-006788-kz8i4a6h	48	56	promoting	promote	VBG
cord-006788-kz8i4a6h	48	57	activity	activity	NN
cord-006788-kz8i4a6h	48	58	.	.	.
cord-006788-kz8i4a6h	49	1	However	however	RB
cord-006788-kz8i4a6h	49	2	,	,	,
cord-006788-kz8i4a6h	49	3	both	both	CC
cord-006788-kz8i4a6h	49	4	the	the	DT
cord-006788-kz8i4a6h	49	5	FGF	FGF	NNP
cord-006788-kz8i4a6h	49	6	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	49	7	and	and	CC
cord-006788-kz8i4a6h	49	8	FGF	FGF	NNP
cord-006788-kz8i4a6h	49	9	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	49	10	axes	axis	NNS
cord-006788-kz8i4a6h	49	11	are	be	VBP
cord-006788-kz8i4a6h	49	12	designed	design	VBN
cord-006788-kz8i4a6h	49	13	to	to	TO
cord-006788-kz8i4a6h	49	14	promote	promote	VB
cord-006788-kz8i4a6h	49	15	cell	cell	NN
cord-006788-kz8i4a6h	49	16	and	and	CC
cord-006788-kz8i4a6h	49	17	organismal	organismal	JJ
cord-006788-kz8i4a6h	49	18	survival	survival	NN
cord-006788-kz8i4a6h	49	19	in	in	IN
cord-006788-kz8i4a6h	49	20	the	the	DT
cord-006788-kz8i4a6h	49	21	vertebrates	vertebrate	NNS
cord-006788-kz8i4a6h	49	22	(	(	-LRB-
cord-006788-kz8i4a6h	49	23	orange	orange	JJ
cord-006788-kz8i4a6h	49	24	arrows	arrow	NNS
cord-006788-kz8i4a6h	49	25	and	and	CC
cord-006788-kz8i4a6h	49	26	blue	blue	JJ
cord-006788-kz8i4a6h	49	27	-	-	HYPH
cord-006788-kz8i4a6h	49	28	colored	colored	JJ
cord-006788-kz8i4a6h	49	29	font	font	NN
cord-006788-kz8i4a6h	49	30	)	)	-RRB-
cord-006788-kz8i4a6h	49	31	.	.	.
cord-006788-kz8i4a6h	50	1	activities	activity	NNS
cord-006788-kz8i4a6h	50	2	of	of	IN
cord-006788-kz8i4a6h	50	3	the	the	DT
cord-006788-kz8i4a6h	50	4	diverse	diverse	JJ
cord-006788-kz8i4a6h	50	5	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	50	6	FGF	FGF	NNP
cord-006788-kz8i4a6h	50	7	axes	axis	NNS
cord-006788-kz8i4a6h	50	8	have	have	VBP
cord-006788-kz8i4a6h	50	9	been	be	VBN
cord-006788-kz8i4a6h	50	10	a	a	DT
cord-006788-kz8i4a6h	50	11	major	major	JJ
cord-006788-kz8i4a6h	50	12	focus	focus	NN
cord-006788-kz8i4a6h	50	13	of	of	IN
cord-006788-kz8i4a6h	50	14	utilities	utility	NNS
cord-006788-kz8i4a6h	50	15	as	as	IN
cord-006788-kz8i4a6h	50	16	regenerative	regenerative	JJ
cord-006788-kz8i4a6h	50	17	and	and	CC
cord-006788-kz8i4a6h	50	18	repair	repair	NN
cord-006788-kz8i4a6h	50	19	agents	agent	NNS
cord-006788-kz8i4a6h	50	20	in	in	IN
cord-006788-kz8i4a6h	50	21	a	a	DT
cord-006788-kz8i4a6h	50	22	range	range	NN
cord-006788-kz8i4a6h	50	23	of	of	IN
cord-006788-kz8i4a6h	50	24	medical	medical	JJ
cord-006788-kz8i4a6h	50	25	settings	setting	NNS
cord-006788-kz8i4a6h	50	26	[	[	-LRB-
cord-006788-kz8i4a6h	50	27	30	30	CD
cord-006788-kz8i4a6h	50	28	]	]	-RRB-
cord-006788-kz8i4a6h	50	29	[	[	-LRB-
cord-006788-kz8i4a6h	50	30	31	31	CD
cord-006788-kz8i4a6h	50	31	]	]	-RRB-
cord-006788-kz8i4a6h	51	1	[	[	-LRB-
cord-006788-kz8i4a6h	51	2	32	32	CD
cord-006788-kz8i4a6h	51	3	]	]	-RRB-
cord-006788-kz8i4a6h	51	4	[	[	-LRB-
cord-006788-kz8i4a6h	51	5	33	33	CD
cord-006788-kz8i4a6h	51	6	]	]	-RRB-
cord-006788-kz8i4a6h	51	7	[	[	-LRB-
cord-006788-kz8i4a6h	51	8	34	34	CD
cord-006788-kz8i4a6h	51	9	]	]	-RRB-
cord-006788-kz8i4a6h	51	10	.	.	.
cord-006788-kz8i4a6h	52	1	In	in	IN
cord-006788-kz8i4a6h	52	2	the	the	DT
cord-006788-kz8i4a6h	52	3	past	past	NN
cord-006788-kz8i4a6h	52	4	,	,	,
cord-006788-kz8i4a6h	52	5	we	-PRON-	PRP
cord-006788-kz8i4a6h	52	6	demonstrated	demonstrate	VBD
cord-006788-kz8i4a6h	52	7	the	the	DT
cord-006788-kz8i4a6h	52	8	benefits	benefit	NNS
cord-006788-kz8i4a6h	52	9	of	of	IN
cord-006788-kz8i4a6h	52	10	the	the	DT
cord-006788-kz8i4a6h	52	11	application	application	NN
cord-006788-kz8i4a6h	52	12	of	of	IN
cord-006788-kz8i4a6h	52	13	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	52	14	FGFs	fgf	NNS
cord-006788-kz8i4a6h	52	15	to	to	IN
cord-006788-kz8i4a6h	52	16	tissue	tissue	NN
cord-006788-kz8i4a6h	52	17	damage	damage	NN
cord-006788-kz8i4a6h	52	18	complications	complication	NNS
cord-006788-kz8i4a6h	52	19	of	of	IN
cord-006788-kz8i4a6h	52	20	diabetes	diabetes	NN
cord-006788-kz8i4a6h	52	21	mellitus	mellitus	NN
cord-006788-kz8i4a6h	52	22	,	,	,
cord-006788-kz8i4a6h	52	23	including	include	VBG
cord-006788-kz8i4a6h	52	24	diabetic	diabetic	JJ
cord-006788-kz8i4a6h	52	25	cardiomyopathy	cardiomyopathy	NN
cord-006788-kz8i4a6h	52	26	,	,	,
cord-006788-kz8i4a6h	52	27	nephropathy	nephropathy	NN
cord-006788-kz8i4a6h	52	28	,	,	,
cord-006788-kz8i4a6h	52	29	and	and	CC
cord-006788-kz8i4a6h	52	30	neuropathy	neuropathy	NN
cord-006788-kz8i4a6h	52	31	[	[	-LRB-
cord-006788-kz8i4a6h	52	32	35	35	CD
cord-006788-kz8i4a6h	52	33	]	]	-RRB-
cord-006788-kz8i4a6h	52	34	[	[	-LRB-
cord-006788-kz8i4a6h	52	35	36	36	CD
cord-006788-kz8i4a6h	52	36	]	]	-RRB-
cord-006788-kz8i4a6h	52	37	[	[	-LRB-
cord-006788-kz8i4a6h	52	38	37	37	CD
cord-006788-kz8i4a6h	52	39	]	]	-RRB-
cord-006788-kz8i4a6h	52	40	,	,	,
cord-006788-kz8i4a6h	52	41	as	as	RB
cord-006788-kz8i4a6h	52	42	well	well	RB
cord-006788-kz8i4a6h	52	43	as	as	IN
cord-006788-kz8i4a6h	52	44	to	to	TO
cord-006788-kz8i4a6h	52	45	wound	wound	VB
cord-006788-kz8i4a6h	52	46	healing	healing	NN
cord-006788-kz8i4a6h	52	47	and	and	CC
cord-006788-kz8i4a6h	52	48	spinal	spinal	JJ
cord-006788-kz8i4a6h	52	49	cord	cord	NN
cord-006788-kz8i4a6h	52	50	injury	injury	NN
cord-006788-kz8i4a6h	52	51	repair	repair	NN
cord-006788-kz8i4a6h	52	52	[	[	-LRB-
cord-006788-kz8i4a6h	52	53	38	38	CD
cord-006788-kz8i4a6h	52	54	]	]	-RRB-
cord-006788-kz8i4a6h	52	55	[	[	-LRB-
cord-006788-kz8i4a6h	52	56	39	39	CD
cord-006788-kz8i4a6h	52	57	]	]	-RRB-
cord-006788-kz8i4a6h	52	58	[	[	-LRB-
cord-006788-kz8i4a6h	52	59	40	40	CD
cord-006788-kz8i4a6h	52	60	]	]	-RRB-
cord-006788-kz8i4a6h	52	61	.	.	.
cord-006788-kz8i4a6h	53	1	On	on	IN
cord-006788-kz8i4a6h	53	2	the	the	DT
cord-006788-kz8i4a6h	53	3	other	other	JJ
cord-006788-kz8i4a6h	53	4	hand	hand	NN
cord-006788-kz8i4a6h	53	5	,	,	,
cord-006788-kz8i4a6h	53	6	the	the	DT
cord-006788-kz8i4a6h	53	7	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	53	8	FGF	FGF	NNP
cord-006788-kz8i4a6h	53	9	mediated	mediate	VBD
cord-006788-kz8i4a6h	53	10	cell	cell	NN
cord-006788-kz8i4a6h	53	11	miscommunications	miscommunication	NNS
cord-006788-kz8i4a6h	53	12	have	have	VBP
cord-006788-kz8i4a6h	53	13	also	also	RB
cord-006788-kz8i4a6h	53	14	been	be	VBN
cord-006788-kz8i4a6h	53	15	on	on	IN
cord-006788-kz8i4a6h	53	16	the	the	DT
cord-006788-kz8i4a6h	53	17	menu	menu	NN
cord-006788-kz8i4a6h	53	18	for	for	IN
cord-006788-kz8i4a6h	53	19	developing	develop	VBG
cord-006788-kz8i4a6h	53	20	inhibitors	inhibitor	NNS
cord-006788-kz8i4a6h	53	21	to	to	TO
cord-006788-kz8i4a6h	53	22	be	be	VB
cord-006788-kz8i4a6h	53	23	used	use	VBN
cord-006788-kz8i4a6h	53	24	in	in	IN
cord-006788-kz8i4a6h	53	25	cancer	cancer	NN
cord-006788-kz8i4a6h	53	26	therapy	therapy	NN
cord-006788-kz8i4a6h	53	27	[	[	-LRB-
cord-006788-kz8i4a6h	53	28	29	29	CD
cord-006788-kz8i4a6h	53	29	,	,	,
cord-006788-kz8i4a6h	53	30	41	41	CD
cord-006788-kz8i4a6h	53	31	,	,	,
cord-006788-kz8i4a6h	53	32	42	42	CD
cord-006788-kz8i4a6h	53	33	]	]	-RRB-
cord-006788-kz8i4a6h	53	34	.	.	.
cord-006788-kz8i4a6h	54	1	It	-PRON-	PRP
cord-006788-kz8i4a6h	54	2	should	should	MD
cord-006788-kz8i4a6h	54	3	be	be	VB
cord-006788-kz8i4a6h	54	4	pointed	point	VBN
cord-006788-kz8i4a6h	54	5	out	out	RP
cord-006788-kz8i4a6h	54	6	that	that	IN
cord-006788-kz8i4a6h	54	7	,	,	,
cord-006788-kz8i4a6h	54	8	although	although	IN
cord-006788-kz8i4a6h	54	9	at	at	IN
cord-006788-kz8i4a6h	54	10	a	a	DT
cord-006788-kz8i4a6h	54	11	physiological	physiological	JJ
cord-006788-kz8i4a6h	54	12	level	level	NN
cord-006788-kz8i4a6h	54	13	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	54	14	FGFs	fgf	NNS
cord-006788-kz8i4a6h	54	15	are	be	VBP
cord-006788-kz8i4a6h	54	16	not	not	RB
cord-006788-kz8i4a6h	54	17	evolutionarily	evolutionarily	RB
cord-006788-kz8i4a6h	54	18	designed	design	VBN
cord-006788-kz8i4a6h	54	19	to	to	TO
cord-006788-kz8i4a6h	54	20	circulate	circulate	VB
cord-006788-kz8i4a6h	54	21	and	and	CC
cord-006788-kz8i4a6h	54	22	target	target	VB
cord-006788-kz8i4a6h	54	23	distal	distal	JJ
cord-006788-kz8i4a6h	54	24	tissues	tissue	NNS
cord-006788-kz8i4a6h	54	25	or	or	CC
cord-006788-kz8i4a6h	54	26	organs	organ	NNS
cord-006788-kz8i4a6h	54	27	for	for	IN
cord-006788-kz8i4a6h	54	28	an	an	DT
cord-006788-kz8i4a6h	54	29	endocrine	endocrine	JJ
cord-006788-kz8i4a6h	54	30	effect	effect	NN
cord-006788-kz8i4a6h	54	31	,	,	,
cord-006788-kz8i4a6h	54	32	at	at	IN
cord-006788-kz8i4a6h	54	33	pharmacological	pharmacological	JJ
cord-006788-kz8i4a6h	54	34	or	or	CC
cord-006788-kz8i4a6h	54	35	supraphysiological	supraphysiological	JJ
cord-006788-kz8i4a6h	54	36	levels	level	NNS
cord-006788-kz8i4a6h	54	37	,	,	,
cord-006788-kz8i4a6h	54	38	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	54	39	FGFs	fgf	NNS
cord-006788-kz8i4a6h	54	40	exert	exert	VBP
cord-006788-kz8i4a6h	54	41	certain	certain	JJ
cord-006788-kz8i4a6h	54	42	regulatory	regulatory	JJ
cord-006788-kz8i4a6h	54	43	activities	activity	NNS
cord-006788-kz8i4a6h	54	44	beyond	beyond	IN
cord-006788-kz8i4a6h	54	45	promoting	promote	VBG
cord-006788-kz8i4a6h	54	46	cell	cell	NN
cord-006788-kz8i4a6h	54	47	proliferation	proliferation	NN
cord-006788-kz8i4a6h	54	48	and	and	CC
cord-006788-kz8i4a6h	54	49	growth	growth	NN
cord-006788-kz8i4a6h	54	50	possibly	possibly	RB
cord-006788-kz8i4a6h	54	51	due	due	IN
cord-006788-kz8i4a6h	54	52	to	to	IN
cord-006788-kz8i4a6h	54	53	their	-PRON-	PRP$
cord-006788-kz8i4a6h	54	54	accumulation	accumulation	NN
cord-006788-kz8i4a6h	54	55	sufficiently	sufficiently	RB
cord-006788-kz8i4a6h	54	56	to	to	TO
cord-006788-kz8i4a6h	54	57	achieve	achieve	VB
cord-006788-kz8i4a6h	54	58	an	an	DT
cord-006788-kz8i4a6h	54	59	effect	effect	NN
cord-006788-kz8i4a6h	54	60	in	in	IN
cord-006788-kz8i4a6h	54	61	distal	distal	JJ
cord-006788-kz8i4a6h	54	62	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	54	63	tissues	tissue	NNS
cord-006788-kz8i4a6h	54	64	,	,	,
cord-006788-kz8i4a6h	54	65	where	where	WRB
cord-006788-kz8i4a6h	54	66	a	a	DT
cord-006788-kz8i4a6h	54	67	cognate	cognate	JJ
cord-006788-kz8i4a6h	54	68	FGFR	FGFR	NNP
cord-006788-kz8i4a6h	54	69	isotype	isotype	NN
cord-006788-kz8i4a6h	54	70	is	be	VBZ
cord-006788-kz8i4a6h	54	71	expressed	express	VBN
cord-006788-kz8i4a6h	54	72	.	.	.
cord-006788-kz8i4a6h	55	1	It	-PRON-	PRP
cord-006788-kz8i4a6h	55	2	was	be	VBD
cord-006788-kz8i4a6h	55	3	shown	show	VBN
cord-006788-kz8i4a6h	55	4	in	in	IN
cord-006788-kz8i4a6h	55	5	the	the	DT
cord-006788-kz8i4a6h	55	6	early	early	JJ
cord-006788-kz8i4a6h	55	7	1990s	1990	NNS
cord-006788-kz8i4a6h	55	8	that	that	IN
cord-006788-kz8i4a6h	55	9	a	a	DT
cord-006788-kz8i4a6h	55	10	bolus	bolus	NN
cord-006788-kz8i4a6h	55	11	intravenous	intravenous	JJ
cord-006788-kz8i4a6h	55	12	injection	injection	NN
cord-006788-kz8i4a6h	55	13	of	of	IN
cord-006788-kz8i4a6h	55	14	FGF1	FGF1	NNP
cord-006788-kz8i4a6h	55	15	or	or	CC
cord-006788-kz8i4a6h	55	16	2	2	CD
cord-006788-kz8i4a6h	55	17	could	could	MD
cord-006788-kz8i4a6h	55	18	target	target	VB
cord-006788-kz8i4a6h	55	19	vascular	vascular	JJ
cord-006788-kz8i4a6h	55	20	endothelium	endothelium	NN
cord-006788-kz8i4a6h	55	21	to	to	TO
cord-006788-kz8i4a6h	55	22	decrease	decrease	VB
cord-006788-kz8i4a6h	55	23	arterial	arterial	JJ
cord-006788-kz8i4a6h	55	24	blood	blood	NN
cord-006788-kz8i4a6h	55	25	pressure	pressure	NN
cord-006788-kz8i4a6h	55	26	[	[	-LRB-
cord-006788-kz8i4a6h	55	27	43	43	CD
cord-006788-kz8i4a6h	55	28	]	]	-RRB-
cord-006788-kz8i4a6h	55	29	.	.	.
cord-006788-kz8i4a6h	56	1	FGF16	FGF16	NNP
cord-006788-kz8i4a6h	56	2	is	be	VBZ
cord-006788-kz8i4a6h	56	3	expressed	express	VBN
cord-006788-kz8i4a6h	56	4	in	in	IN
cord-006788-kz8i4a6h	56	5	classical	classical	JJ
cord-006788-kz8i4a6h	56	6	brown	brown	JJ
cord-006788-kz8i4a6h	56	7	fat	fat	JJ
cord-006788-kz8i4a6h	56	8	depots	depot	NNS
cord-006788-kz8i4a6h	56	9	during	during	IN
cord-006788-kz8i4a6h	56	10	the	the	DT
cord-006788-kz8i4a6h	56	11	later	later	JJ
cord-006788-kz8i4a6h	56	12	stages	stage	NNS
cord-006788-kz8i4a6h	56	13	of	of	IN
cord-006788-kz8i4a6h	56	14	embryonic	embryonic	JJ
cord-006788-kz8i4a6h	56	15	development	development	NN
cord-006788-kz8i4a6h	56	16	,	,	,
cord-006788-kz8i4a6h	56	17	and	and	CC
cord-006788-kz8i4a6h	56	18	recombinant	recombinant	JJ
cord-006788-kz8i4a6h	56	19	FGF16	FGF16	NNP
cord-006788-kz8i4a6h	56	20	is	be	VBZ
cord-006788-kz8i4a6h	56	21	a	a	DT
cord-006788-kz8i4a6h	56	22	mitogen	mitogen	NN
cord-006788-kz8i4a6h	56	23	for	for	IN
cord-006788-kz8i4a6h	56	24	adipocytes	adipocyte	NNS
cord-006788-kz8i4a6h	56	25	[	[	-LRB-
cord-006788-kz8i4a6h	56	26	44	44	CD
cord-006788-kz8i4a6h	56	27	]	]	-RRB-
cord-006788-kz8i4a6h	56	28	.	.	.
cord-006788-kz8i4a6h	57	1	Mice	mice	NN
cord-006788-kz8i4a6h	57	2	overexpressing	overexpresse	VBG
cord-006788-kz8i4a6h	57	3	FGF16	fgf16	NN
cord-006788-kz8i4a6h	57	4	delivered	deliver	VBN
cord-006788-kz8i4a6h	57	5	by	by	IN
cord-006788-kz8i4a6h	57	6	adeno	adeno	NN
cord-006788-kz8i4a6h	57	7	-	-	HYPH
cord-006788-kz8i4a6h	57	8	associated	associate	VBN
cord-006788-kz8i4a6h	57	9	virus	virus	NN
cord-006788-kz8i4a6h	57	10	display	display	VBP
cord-006788-kz8i4a6h	57	11	dramatic	dramatic	JJ
cord-006788-kz8i4a6h	57	12	weight	weight	NN
cord-006788-kz8i4a6h	57	13	loss	loss	NN
cord-006788-kz8i4a6h	57	14	and	and	CC
cord-006788-kz8i4a6h	57	15	uncoupling	uncoupling	NN
cord-006788-kz8i4a6h	57	16	protein-1	protein-1	NNP
cord-006788-kz8i4a6h	57	17	(	(	-LRB-
cord-006788-kz8i4a6h	57	18	UCP1	UCP1	NNP
cord-006788-kz8i4a6h	57	19	)	)	-RRB-
cord-006788-kz8i4a6h	57	20	upregulation	upregulation	NN
cord-006788-kz8i4a6h	57	21	in	in	IN
cord-006788-kz8i4a6h	57	22	inguinal	inguinal	JJ
cord-006788-kz8i4a6h	57	23	white	white	JJ
cord-006788-kz8i4a6h	57	24	adipose	adipose	JJ
cord-006788-kz8i4a6h	57	25	tissue	tissue	NN
cord-006788-kz8i4a6h	57	26	(	(	-LRB-
cord-006788-kz8i4a6h	57	27	WAT	WAT	NNP
cord-006788-kz8i4a6h	57	28	)	)	-RRB-
cord-006788-kz8i4a6h	57	29	,	,	,
cord-006788-kz8i4a6h	57	30	which	which	WDT
cord-006788-kz8i4a6h	57	31	is	be	VBZ
cord-006788-kz8i4a6h	57	32	a	a	DT
cord-006788-kz8i4a6h	57	33	common	common	JJ
cord-006788-kz8i4a6h	57	34	site	site	NN
cord-006788-kz8i4a6h	57	35	for	for	IN
cord-006788-kz8i4a6h	57	36	emergent	emergent	JJ
cord-006788-kz8i4a6h	57	37	active	active	JJ
cord-006788-kz8i4a6h	57	38	brown	brown	JJ
cord-006788-kz8i4a6h	57	39	adipose	adipose	JJ
cord-006788-kz8i4a6h	57	40	tissue	tissue	NN
cord-006788-kz8i4a6h	57	41	(	(	-LRB-
cord-006788-kz8i4a6h	57	42	BAT	bat	NN
cord-006788-kz8i4a6h	57	43	)	)	-RRB-
cord-006788-kz8i4a6h	57	44	.	.	.
cord-006788-kz8i4a6h	58	1	These	these	DT
cord-006788-kz8i4a6h	58	2	effects	effect	NNS
cord-006788-kz8i4a6h	58	3	are	be	VBP
cord-006788-kz8i4a6h	58	4	likely	likely	RB
cord-006788-kz8i4a6h	58	5	a	a	DT
cord-006788-kz8i4a6h	58	6	combined	combined	JJ
cord-006788-kz8i4a6h	58	7	result	result	NN
cord-006788-kz8i4a6h	58	8	of	of	IN
cord-006788-kz8i4a6h	58	9	reduced	reduce	VBN
cord-006788-kz8i4a6h	58	10	food	food	NN
cord-006788-kz8i4a6h	58	11	and	and	CC
cord-006788-kz8i4a6h	58	12	water	water	NN
cord-006788-kz8i4a6h	58	13	intake	intake	NN
cord-006788-kz8i4a6h	58	14	and	and	CC
cord-006788-kz8i4a6h	58	15	abnormal	abnormal	JJ
cord-006788-kz8i4a6h	58	16	feces	fece	NNS
cord-006788-kz8i4a6h	58	17	replete	replete	JJ
cord-006788-kz8i4a6h	58	18	with	with	IN
cord-006788-kz8i4a6h	58	19	lipid	lipid	NN
cord-006788-kz8i4a6h	58	20	and	and	CC
cord-006788-kz8i4a6h	58	21	bile	bile	NN
cord-006788-kz8i4a6h	58	22	acid	acid	NN
cord-006788-kz8i4a6h	58	23	due	due	IN
cord-006788-kz8i4a6h	58	24	to	to	IN
cord-006788-kz8i4a6h	58	25	the	the	DT
cord-006788-kz8i4a6h	58	26	brain	brain	NN
cord-006788-kz8i4a6h	58	27	,	,	,
cord-006788-kz8i4a6h	58	28	liver	liver	NN
cord-006788-kz8i4a6h	58	29	,	,	,
cord-006788-kz8i4a6h	58	30	and	and	CC
cord-006788-kz8i4a6h	58	31	intestinal	intestinal	JJ
cord-006788-kz8i4a6h	58	32	actions	action	NNS
cord-006788-kz8i4a6h	58	33	of	of	IN
cord-006788-kz8i4a6h	58	34	overexpressed	overexpresse	VBN
cord-006788-kz8i4a6h	58	35	FGF16	FGF16	.
cord-006788-kz8i4a6h	58	36	[	[	-LRB-
cord-006788-kz8i4a6h	58	37	45	45	CD
cord-006788-kz8i4a6h	58	38	]	]	-RRB-
cord-006788-kz8i4a6h	58	39	.	.	.
cord-006788-kz8i4a6h	59	1	Mice	mouse	NNS
cord-006788-kz8i4a6h	59	2	deficient	deficient	JJ
cord-006788-kz8i4a6h	59	3	in	in	IN
cord-006788-kz8i4a6h	59	4	FGF1	FGF1	NNP
cord-006788-kz8i4a6h	59	5	exhibit	exhibit	VBP
cord-006788-kz8i4a6h	59	6	insignificant	insignificant	JJ
cord-006788-kz8i4a6h	59	7	phenotypes	phenotype	NNS
cord-006788-kz8i4a6h	59	8	under	under	IN
cord-006788-kz8i4a6h	59	9	standard	standard	JJ
cord-006788-kz8i4a6h	59	10	dietary	dietary	JJ
cord-006788-kz8i4a6h	59	11	conditions	condition	NNS
cord-006788-kz8i4a6h	59	12	;	;	:
cord-006788-kz8i4a6h	59	13	however	however	RB
cord-006788-kz8i4a6h	59	14	,	,	,
cord-006788-kz8i4a6h	59	15	under	under	IN
cord-006788-kz8i4a6h	59	16	a	a	DT
cord-006788-kz8i4a6h	59	17	chronic	chronic	JJ
cord-006788-kz8i4a6h	59	18	high	high	JJ
cord-006788-kz8i4a6h	59	19	-	-	HYPH
cord-006788-kz8i4a6h	59	20	fat	fat	NN
cord-006788-kz8i4a6h	59	21	diet	diet	NN
cord-006788-kz8i4a6h	59	22	,	,	,
cord-006788-kz8i4a6h	59	23	these	these	DT
cord-006788-kz8i4a6h	59	24	mice	mouse	NNS
cord-006788-kz8i4a6h	59	25	develop	develop	VBP
cord-006788-kz8i4a6h	59	26	an	an	DT
cord-006788-kz8i4a6h	59	27	aggressive	aggressive	JJ
cord-006788-kz8i4a6h	59	28	diabetic	diabetic	JJ
cord-006788-kz8i4a6h	59	29	phenotype	phenotype	NN
cord-006788-kz8i4a6h	59	30	coupled	couple	VBN
cord-006788-kz8i4a6h	59	31	with	with	IN
cord-006788-kz8i4a6h	59	32	aberrant	aberrant	JJ
cord-006788-kz8i4a6h	59	33	adipose	adipose	JJ
cord-006788-kz8i4a6h	59	34	phenotypes	phenotype	NNS
cord-006788-kz8i4a6h	59	35	,	,	,
cord-006788-kz8i4a6h	59	36	including	include	VBG
cord-006788-kz8i4a6h	59	37	multiple	multiple	JJ
cord-006788-kz8i4a6h	59	38	histopathologies	histopathologie	NNS
cord-006788-kz8i4a6h	59	39	in	in	IN
cord-006788-kz8i4a6h	59	40	the	the	DT
cord-006788-kz8i4a6h	59	41	adipose	adipose	JJ
cord-006788-kz8i4a6h	59	42	vasculature	vasculature	NN
cord-006788-kz8i4a6h	59	43	network	network	NN
cord-006788-kz8i4a6h	59	44	,	,	,
cord-006788-kz8i4a6h	59	45	accentuated	accentuate	VBD
cord-006788-kz8i4a6h	59	46	inflammatory	inflammatory	JJ
cord-006788-kz8i4a6h	59	47	response	response	NN
cord-006788-kz8i4a6h	59	48	,	,	,
cord-006788-kz8i4a6h	59	49	aberrant	aberrant	JJ
cord-006788-kz8i4a6h	59	50	adipocyte	adipocyte	NN
cord-006788-kz8i4a6h	59	51	size	size	NN
cord-006788-kz8i4a6h	59	52	distribution	distribution	NN
cord-006788-kz8i4a6h	59	53	and	and	CC
cord-006788-kz8i4a6h	59	54	expansion	expansion	NN
cord-006788-kz8i4a6h	59	55	,	,	,
cord-006788-kz8i4a6h	59	56	and	and	CC
cord-006788-kz8i4a6h	59	57	ectopic	ectopic	JJ
cord-006788-kz8i4a6h	59	58	expression	expression	NN
cord-006788-kz8i4a6h	59	59	of	of	IN
cord-006788-kz8i4a6h	59	60	pancreatic	pancreatic	JJ
cord-006788-kz8i4a6h	59	61	lipases	lipase	NNS
cord-006788-kz8i4a6h	59	62	[	[	-LRB-
cord-006788-kz8i4a6h	59	63	46	46	CD
cord-006788-kz8i4a6h	59	64	]	]	-RRB-
cord-006788-kz8i4a6h	59	65	.	.	.
cord-006788-kz8i4a6h	60	1	In	in	IN
cord-006788-kz8i4a6h	60	2	particular	particular	JJ
cord-006788-kz8i4a6h	60	3	,	,	,
cord-006788-kz8i4a6h	60	4	we	-PRON-	PRP
cord-006788-kz8i4a6h	60	5	show	show	VBP
cord-006788-kz8i4a6h	60	6	by	by	IN
cord-006788-kz8i4a6h	60	7	structure	structure	NN
cord-006788-kz8i4a6h	60	8	-	-	HYPH
cord-006788-kz8i4a6h	60	9	based	base	VBN
cord-006788-kz8i4a6h	60	10	mutagenesis	mutagenesis	NN
cord-006788-kz8i4a6h	60	11	that	that	WDT
cord-006788-kz8i4a6h	60	12	FGF1	FGF1	NNP
cord-006788-kz8i4a6h	60	13	can	can	MD
cord-006788-kz8i4a6h	60	14	be	be	VB
cord-006788-kz8i4a6h	60	15	designed	design	VBN
cord-006788-kz8i4a6h	60	16	to	to	TO
cord-006788-kz8i4a6h	60	17	have	have	VB
cord-006788-kz8i4a6h	60	18	full	full	JJ
cord-006788-kz8i4a6h	60	19	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	60	20	activity	activity	NN
cord-006788-kz8i4a6h	60	21	of	of	IN
cord-006788-kz8i4a6h	60	22	wild	wild	JJ
cord-006788-kz8i4a6h	60	23	-	-	HYPH
cord-006788-kz8i4a6h	60	24	type	type	NN
cord-006788-kz8i4a6h	60	25	FGF1	FGF1	NNP
cord-006788-kz8i4a6h	60	26	but	but	CC
cord-006788-kz8i4a6h	60	27	with	with	IN
cord-006788-kz8i4a6h	60	28	reduced	reduce	VBN
cord-006788-kz8i4a6h	60	29	proliferative	proliferative	JJ
cord-006788-kz8i4a6h	60	30	potential	potential	NN
cord-006788-kz8i4a6h	60	31	both	both	CC
cord-006788-kz8i4a6h	60	32	in	in	IN
cord-006788-kz8i4a6h	60	33	vitro	vitro	FW
cord-006788-kz8i4a6h	60	34	and	and	CC
cord-006788-kz8i4a6h	60	35	in	in	IN
cord-006788-kz8i4a6h	60	36	vivo	vivo	NNP
cord-006788-kz8i4a6h	60	37	[	[	-LRB-
cord-006788-kz8i4a6h	60	38	47	47	CD
cord-006788-kz8i4a6h	60	39	]	]	-RRB-
cord-006788-kz8i4a6h	60	40	.	.	.
cord-006788-kz8i4a6h	61	1	These	these	DT
cord-006788-kz8i4a6h	61	2	studies	study	NNS
cord-006788-kz8i4a6h	61	3	underscore	underscore	VBP
cord-006788-kz8i4a6h	61	4	the	the	DT
cord-006788-kz8i4a6h	61	5	important	important	JJ
cord-006788-kz8i4a6h	61	6	role	role	NN
cord-006788-kz8i4a6h	61	7	of	of	IN
cord-006788-kz8i4a6h	61	8	FGF1	FGF1	NNP
cord-006788-kz8i4a6h	61	9	in	in	IN
cord-006788-kz8i4a6h	61	10	maintaining	maintain	VBG
cord-006788-kz8i4a6h	61	11	local	local	JJ
cord-006788-kz8i4a6h	61	12	adipose	adipose	JJ
cord-006788-kz8i4a6h	61	13	tissue	tissue	NN
cord-006788-kz8i4a6h	61	14	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	61	15	,	,	,
cord-006788-kz8i4a6h	61	16	which	which	WDT
cord-006788-kz8i4a6h	61	17	upon	upon	IN
cord-006788-kz8i4a6h	61	18	significant	significant	JJ
cord-006788-kz8i4a6h	61	19	tissue	tissue	NN
cord-006788-kz8i4a6h	61	20	perturbations	perturbation	NNS
cord-006788-kz8i4a6h	61	21	impinges	impinge	VBZ
cord-006788-kz8i4a6h	61	22	on	on	IN
cord-006788-kz8i4a6h	61	23	the	the	DT
cord-006788-kz8i4a6h	61	24	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	61	25	functions	function	NNS
cord-006788-kz8i4a6h	61	26	that	that	WDT
cord-006788-kz8i4a6h	61	27	subsequently	subsequently	RB
cord-006788-kz8i4a6h	61	28	affect	affect	VBP
cord-006788-kz8i4a6h	61	29	the	the	DT
cord-006788-kz8i4a6h	61	30	systemic	systemic	JJ
cord-006788-kz8i4a6h	61	31	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	61	32	state	state	NN
cord-006788-kz8i4a6h	61	33	.	.	.
cord-006788-kz8i4a6h	62	1	Thus	thus	RB
cord-006788-kz8i4a6h	62	2	,	,	,
cord-006788-kz8i4a6h	62	3	the	the	DT
cord-006788-kz8i4a6h	62	4	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	62	5	effects	effect	NNS
cord-006788-kz8i4a6h	62	6	of	of	IN
cord-006788-kz8i4a6h	62	7	several	several	JJ
cord-006788-kz8i4a6h	62	8	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	62	9	FGF	FGF	NNP
cord-006788-kz8i4a6h	62	10	axes	axis	NNS
cord-006788-kz8i4a6h	62	11	may	may	MD
cord-006788-kz8i4a6h	62	12	be	be	VB
cord-006788-kz8i4a6h	62	13	due	due	JJ
cord-006788-kz8i4a6h	62	14	to	to	IN
cord-006788-kz8i4a6h	62	15	either	either	CC
cord-006788-kz8i4a6h	62	16	a	a	DT
cord-006788-kz8i4a6h	62	17	local	local	JJ
cord-006788-kz8i4a6h	62	18	function	function	NN
cord-006788-kz8i4a6h	62	19	in	in	IN
cord-006788-kz8i4a6h	62	20	maintaining	maintain	VBG
cord-006788-kz8i4a6h	62	21	cellular	cellular	JJ
cord-006788-kz8i4a6h	62	22	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	62	23	that	that	WDT
cord-006788-kz8i4a6h	62	24	is	be	VBZ
cord-006788-kz8i4a6h	62	25	closely	closely	RB
cord-006788-kz8i4a6h	62	26	associated	associate	VBN
cord-006788-kz8i4a6h	62	27	with	with	IN
cord-006788-kz8i4a6h	62	28	local	local	JJ
cord-006788-kz8i4a6h	62	29	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	62	30	state	state	NN
cord-006788-kz8i4a6h	62	31	at	at	IN
cord-006788-kz8i4a6h	62	32	a	a	DT
cord-006788-kz8i4a6h	62	33	physiological	physiological	JJ
cord-006788-kz8i4a6h	62	34	concentration	concentration	NN
cord-006788-kz8i4a6h	62	35	or	or	CC
cord-006788-kz8i4a6h	62	36	an	an	DT
cord-006788-kz8i4a6h	62	37	induced	induce	VBN
cord-006788-kz8i4a6h	62	38	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	62	39	response	response	NN
cord-006788-kz8i4a6h	62	40	to	to	IN
cord-006788-kz8i4a6h	62	41	a	a	DT
cord-006788-kz8i4a6h	62	42	supraphysiological	supraphysiological	JJ
cord-006788-kz8i4a6h	62	43	concentration	concentration	NN
cord-006788-kz8i4a6h	62	44	from	from	IN
cord-006788-kz8i4a6h	62	45	circulation	circulation	NN
cord-006788-kz8i4a6h	62	46	in	in	IN
cord-006788-kz8i4a6h	62	47	the	the	DT
cord-006788-kz8i4a6h	62	48	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	62	49	tissues	tissue	NNS
cord-006788-kz8i4a6h	62	50	or	or	CC
cord-006788-kz8i4a6h	62	51	organs	organ	NNS
cord-006788-kz8i4a6h	62	52	where	where	WRB
cord-006788-kz8i4a6h	62	53	FGFR	FGFR	NNP
cord-006788-kz8i4a6h	62	54	resides	reside	VBZ
cord-006788-kz8i4a6h	62	55	.	.	.
cord-006788-kz8i4a6h	63	1	However	however	RB
cord-006788-kz8i4a6h	63	2	,	,	,
cord-006788-kz8i4a6h	63	3	at	at	IN
cord-006788-kz8i4a6h	63	4	pharmacological	pharmacological	JJ
cord-006788-kz8i4a6h	63	5	levels	level	NNS
cord-006788-kz8i4a6h	63	6	,	,	,
cord-006788-kz8i4a6h	63	7	few	few	JJ
cord-006788-kz8i4a6h	63	8	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	63	9	FGFs	fgf	NNS
cord-006788-kz8i4a6h	63	10	may	may	MD
cord-006788-kz8i4a6h	63	11	also	also	RB
cord-006788-kz8i4a6h	63	12	be	be	VB
cord-006788-kz8i4a6h	63	13	designed	design	VBN
cord-006788-kz8i4a6h	63	14	to	to	TO
cord-006788-kz8i4a6h	63	15	elicit	elicit	VB
cord-006788-kz8i4a6h	63	16	systemic	systemic	JJ
cord-006788-kz8i4a6h	63	17	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	63	18	effects	effect	NNS
cord-006788-kz8i4a6h	63	19	.	.	.
cord-006788-kz8i4a6h	64	1	In	in	IN
cord-006788-kz8i4a6h	64	2	contrast	contrast	NN
cord-006788-kz8i4a6h	64	3	to	to	IN
cord-006788-kz8i4a6h	64	4	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	64	5	FGFs	FGFs	NNP
cord-006788-kz8i4a6h	64	6	,	,	,
cord-006788-kz8i4a6h	64	7	the	the	DT
cord-006788-kz8i4a6h	64	8	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	64	9	FGF	FGF	NNP
cord-006788-kz8i4a6h	64	10	subfamily	subfamily	NN
cord-006788-kz8i4a6h	64	11	contains	contain	VBZ
cord-006788-kz8i4a6h	64	12	only	only	RB
cord-006788-kz8i4a6h	64	13	three	three	CD
cord-006788-kz8i4a6h	64	14	members	member	NNS
cord-006788-kz8i4a6h	64	15	,	,	,
cord-006788-kz8i4a6h	64	16	namely	namely	RB
cord-006788-kz8i4a6h	64	17	,	,	,
cord-006788-kz8i4a6h	64	18	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	64	19	(	(	-LRB-
cord-006788-kz8i4a6h	64	20	mouse	mouse	NN
cord-006788-kz8i4a6h	64	21	FGF15	FGF15	NNP
cord-006788-kz8i4a6h	64	22	)	)	-RRB-
cord-006788-kz8i4a6h	64	23	,	,	,
cord-006788-kz8i4a6h	64	24	21	21	CD
cord-006788-kz8i4a6h	64	25	,	,	,
cord-006788-kz8i4a6h	64	26	and	and	CC
cord-006788-kz8i4a6h	64	27	23	23	CD
cord-006788-kz8i4a6h	64	28	[	[	-LRB-
cord-006788-kz8i4a6h	64	29	2	2	CD
cord-006788-kz8i4a6h	64	30	,	,	,
cord-006788-kz8i4a6h	64	31	7	7	CD
cord-006788-kz8i4a6h	64	32	,	,	,
cord-006788-kz8i4a6h	64	33	[	[	-LRB-
cord-006788-kz8i4a6h	64	34	48	48	CD
cord-006788-kz8i4a6h	64	35	]	]	-RRB-
cord-006788-kz8i4a6h	64	36	[	[	-LRB-
cord-006788-kz8i4a6h	64	37	49	49	CD
cord-006788-kz8i4a6h	64	38	]	]	-RRB-
cord-006788-kz8i4a6h	64	39	[	[	-LRB-
cord-006788-kz8i4a6h	64	40	50	50	CD
cord-006788-kz8i4a6h	64	41	]	]	-RRB-
cord-006788-kz8i4a6h	64	42	[	[	-LRB-
cord-006788-kz8i4a6h	64	43	51	51	CD
cord-006788-kz8i4a6h	64	44	]	]	-RRB-
cord-006788-kz8i4a6h	64	45	.	.	.
cord-006788-kz8i4a6h	65	1	However	however	RB
cord-006788-kz8i4a6h	65	2	,	,	,
cord-006788-kz8i4a6h	65	3	the	the	DT
cord-006788-kz8i4a6h	65	4	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	65	5	axes	axis	NNS
cord-006788-kz8i4a6h	65	6	of	of	IN
cord-006788-kz8i4a6h	65	7	these	these	DT
cord-006788-kz8i4a6h	65	8	three	three	CD
cord-006788-kz8i4a6h	65	9	FGFs	fgf	NNS
cord-006788-kz8i4a6h	65	10	regulate	regulate	VBP
cord-006788-kz8i4a6h	65	11	a	a	DT
cord-006788-kz8i4a6h	65	12	wide	wide	JJ
cord-006788-kz8i4a6h	65	13	range	range	NN
cord-006788-kz8i4a6h	65	14	of	of	IN
cord-006788-kz8i4a6h	65	15	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	65	16	pathways	pathway	NNS
cord-006788-kz8i4a6h	65	17	,	,	,
cord-006788-kz8i4a6h	65	18	resulting	result	VBG
cord-006788-kz8i4a6h	65	19	in	in	IN
cord-006788-kz8i4a6h	65	20	tissue	tissue	NN
cord-006788-kz8i4a6h	65	21	and	and	CC
cord-006788-kz8i4a6h	65	22	organismal	organismal	JJ
cord-006788-kz8i4a6h	65	23	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	65	24	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	65	25	of	of	IN
cord-006788-kz8i4a6h	65	26	bile	bile	NN
cord-006788-kz8i4a6h	65	27	acids	acid	NNS
cord-006788-kz8i4a6h	65	28	,	,	,
cord-006788-kz8i4a6h	65	29	lipid	lipid	NN
cord-006788-kz8i4a6h	65	30	,	,	,
cord-006788-kz8i4a6h	65	31	glucose	glucose	NN
cord-006788-kz8i4a6h	65	32	,	,	,
cord-006788-kz8i4a6h	65	33	energy	energy	NN
cord-006788-kz8i4a6h	65	34	,	,	,
cord-006788-kz8i4a6h	65	35	and	and	CC
cord-006788-kz8i4a6h	65	36	minerals	mineral	NNS
cord-006788-kz8i4a6h	65	37	.	.	.
cord-006788-kz8i4a6h	66	1	Although	although	IN
cord-006788-kz8i4a6h	66	2	the	the	DT
cord-006788-kz8i4a6h	66	3	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	66	4	FGF	FGF	NNP
cord-006788-kz8i4a6h	66	5	axes	axis	NNS
cord-006788-kz8i4a6h	66	6	do	do	VBP
cord-006788-kz8i4a6h	66	7	not	not	RB
cord-006788-kz8i4a6h	66	8	overtly	overtly	RB
cord-006788-kz8i4a6h	66	9	promote	promote	VB
cord-006788-kz8i4a6h	66	10	DNA	dna	NN
cord-006788-kz8i4a6h	66	11	synthesis	synthesis	NN
cord-006788-kz8i4a6h	66	12	,	,	,
cord-006788-kz8i4a6h	66	13	thereby	thereby	RB
cord-006788-kz8i4a6h	66	14	leading	lead	VBG
cord-006788-kz8i4a6h	66	15	to	to	IN
cord-006788-kz8i4a6h	66	16	cell	cell	NN
cord-006788-kz8i4a6h	66	17	proliferation	proliferation	NN
cord-006788-kz8i4a6h	66	18	[	[	-LRB-
cord-006788-kz8i4a6h	66	19	12	12	CD
cord-006788-kz8i4a6h	66	20	,	,	,
cord-006788-kz8i4a6h	66	21	52	52	CD
cord-006788-kz8i4a6h	66	22	,	,	,
cord-006788-kz8i4a6h	66	23	53	53	CD
cord-006788-kz8i4a6h	66	24	]	]	-RRB-
cord-006788-kz8i4a6h	66	25	,	,	,
cord-006788-kz8i4a6h	66	26	both	both	CC
cord-006788-kz8i4a6h	66	27	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	66	28	and	and	CC
cord-006788-kz8i4a6h	66	29	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	66	30	FGF	FGF	NNP
cord-006788-kz8i4a6h	66	31	axes	axis	NNS
cord-006788-kz8i4a6h	66	32	appear	appear	VBP
cord-006788-kz8i4a6h	66	33	to	to	TO
cord-006788-kz8i4a6h	66	34	enhance	enhance	VB
cord-006788-kz8i4a6h	66	35	cell	cell	NN
cord-006788-kz8i4a6h	66	36	survival	survival	NN
cord-006788-kz8i4a6h	66	37	and	and	CC
cord-006788-kz8i4a6h	66	38	promote	promote	VB
cord-006788-kz8i4a6h	66	39	an	an	DT
cord-006788-kz8i4a6h	66	40	optimal	optimal	JJ
cord-006788-kz8i4a6h	66	41	state	state	NN
cord-006788-kz8i4a6h	66	42	of	of	IN
cord-006788-kz8i4a6h	66	43	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	66	44	in	in	IN
cord-006788-kz8i4a6h	66	45	the	the	DT
cord-006788-kz8i4a6h	66	46	target	target	NN
cord-006788-kz8i4a6h	66	47	tissues	tissue	NNS
cord-006788-kz8i4a6h	66	48	and	and	CC
cord-006788-kz8i4a6h	66	49	organisms	organism	NNS
cord-006788-kz8i4a6h	66	50	[	[	-LRB-
cord-006788-kz8i4a6h	66	51	7	7	CD
cord-006788-kz8i4a6h	66	52	]	]	-RRB-
cord-006788-kz8i4a6h	66	53	.	.	.
cord-006788-kz8i4a6h	67	1	Based	base	VBN
cord-006788-kz8i4a6h	67	2	on	on	IN
cord-006788-kz8i4a6h	67	3	current	current	JJ
cord-006788-kz8i4a6h	67	4	knowledge	knowledge	NN
cord-006788-kz8i4a6h	67	5	,	,	,
cord-006788-kz8i4a6h	67	6	the	the	DT
cord-006788-kz8i4a6h	67	7	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	67	8	FGFs	fgf	NNS
cord-006788-kz8i4a6h	67	9	appear	appear	VBP
cord-006788-kz8i4a6h	67	10	to	to	TO
cord-006788-kz8i4a6h	67	11	originate	originate	VB
cord-006788-kz8i4a6h	67	12	from	from	IN
cord-006788-kz8i4a6h	67	13	a	a	DT
cord-006788-kz8i4a6h	67	14	common	common	JJ
cord-006788-kz8i4a6h	67	15	FGF13-like	fgf13-like	CD
cord-006788-kz8i4a6h	67	16	ancestor	ancestor	NN
cord-006788-kz8i4a6h	67	17	molecule	molecule	NN
cord-006788-kz8i4a6h	67	18	as	as	IN
cord-006788-kz8i4a6h	67	19	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	67	20	FGFs	fgf	NNS
cord-006788-kz8i4a6h	67	21	and	and	CC
cord-006788-kz8i4a6h	67	22	then	then	RB
cord-006788-kz8i4a6h	67	23	bifurcate	bifurcate	VB
cord-006788-kz8i4a6h	67	24	in	in	IN
cord-006788-kz8i4a6h	67	25	early	early	JJ
cord-006788-kz8i4a6h	67	26	evolution	evolution	NN
cord-006788-kz8i4a6h	67	27	through	through	IN
cord-006788-kz8i4a6h	67	28	an	an	DT
cord-006788-kz8i4a6h	67	29	FGF4-like	FGF4-like	NNP
cord-006788-kz8i4a6h	67	30	molecule	molecule	NN
cord-006788-kz8i4a6h	67	31	from	from	IN
cord-006788-kz8i4a6h	67	32	all	all	DT
cord-006788-kz8i4a6h	67	33	other	other	JJ
cord-006788-kz8i4a6h	67	34	mitogenic	mitogenic	JJ
cord-006788-kz8i4a6h	67	35	members	member	NNS
cord-006788-kz8i4a6h	67	36	by	by	IN
cord-006788-kz8i4a6h	67	37	acquiring	acquire	VBG
cord-006788-kz8i4a6h	67	38	unique	unique	JJ
cord-006788-kz8i4a6h	67	39	structural	structural	JJ
cord-006788-kz8i4a6h	67	40	and	and	CC
cord-006788-kz8i4a6h	67	41	mechanistic	mechanistic	JJ
cord-006788-kz8i4a6h	67	42	properties	property	NNS
cord-006788-kz8i4a6h	67	43	[	[	-LRB-
cord-006788-kz8i4a6h	67	44	5	5	CD
cord-006788-kz8i4a6h	67	45	,	,	,
cord-006788-kz8i4a6h	67	46	10	10	CD
cord-006788-kz8i4a6h	67	47	,	,	,
cord-006788-kz8i4a6h	67	48	11	11	CD
cord-006788-kz8i4a6h	67	49	,	,	,
cord-006788-kz8i4a6h	67	50	54	54	CD
cord-006788-kz8i4a6h	67	51	]	]	-RRB-
cord-006788-kz8i4a6h	67	52	,	,	,
cord-006788-kz8i4a6h	67	53	thereby	thereby	RB
cord-006788-kz8i4a6h	67	54	leading	lead	VBG
cord-006788-kz8i4a6h	67	55	to	to	IN
cord-006788-kz8i4a6h	67	56	specific	specific	JJ
cord-006788-kz8i4a6h	67	57	activities	activity	NNS
cord-006788-kz8i4a6h	67	58	in	in	IN
cord-006788-kz8i4a6h	67	59	modulating	modulate	VBG
cord-006788-kz8i4a6h	67	60	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	67	61	states	state	NNS
cord-006788-kz8i4a6h	67	62	in	in	IN
cord-006788-kz8i4a6h	67	63	specific	specific	JJ
cord-006788-kz8i4a6h	67	64	cell	cell	NN
cord-006788-kz8i4a6h	67	65	and	and	CC
cord-006788-kz8i4a6h	67	66	tissue	tissue	NN
cord-006788-kz8i4a6h	67	67	types	type	NNS
cord-006788-kz8i4a6h	67	68	[	[	-LRB-
cord-006788-kz8i4a6h	67	69	2	2	CD
cord-006788-kz8i4a6h	67	70	]	]	-RRB-
cord-006788-kz8i4a6h	67	71	.	.	.
cord-006788-kz8i4a6h	68	1	Instead	instead	RB
cord-006788-kz8i4a6h	68	2	of	of	IN
cord-006788-kz8i4a6h	68	3	acting	act	VBG
cord-006788-kz8i4a6h	68	4	locally	locally	RB
cord-006788-kz8i4a6h	68	5	,	,	,
cord-006788-kz8i4a6h	68	6	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	68	7	FGFs	fgf	NNS
cord-006788-kz8i4a6h	68	8	take	take	VBP
cord-006788-kz8i4a6h	68	9	a	a	DT
cord-006788-kz8i4a6h	68	10	hormonal	hormonal	JJ
cord-006788-kz8i4a6h	68	11	or	or	CC
cord-006788-kz8i4a6h	68	12	endocrine	endocrine	JJ
cord-006788-kz8i4a6h	68	13	route	route	NN
cord-006788-kz8i4a6h	68	14	of	of	IN
cord-006788-kz8i4a6h	68	15	action	action	NN
cord-006788-kz8i4a6h	68	16	by	by	IN
cord-006788-kz8i4a6h	68	17	traveling	travel	VBG
cord-006788-kz8i4a6h	68	18	through	through	IN
cord-006788-kz8i4a6h	68	19	circulation	circulation	NN
cord-006788-kz8i4a6h	68	20	from	from	IN
cord-006788-kz8i4a6h	68	21	the	the	DT
cord-006788-kz8i4a6h	68	22	originating	originate	VBG
cord-006788-kz8i4a6h	68	23	tissue	tissue	NN
cord-006788-kz8i4a6h	68	24	to	to	IN
cord-006788-kz8i4a6h	68	25	other	other	JJ
cord-006788-kz8i4a6h	68	26	peripheral	peripheral	JJ
cord-006788-kz8i4a6h	68	27	tissues	tissue	NNS
cord-006788-kz8i4a6h	68	28	/	/	SYM
cord-006788-kz8i4a6h	68	29	organs	organ	NNS
cord-006788-kz8i4a6h	68	30	.	.	.
cord-006788-kz8i4a6h	69	1	This	this	DT
cord-006788-kz8i4a6h	69	2	endocrine	endocrine	JJ
cord-006788-kz8i4a6h	69	3	action	action	NN
cord-006788-kz8i4a6h	69	4	can	can	MD
cord-006788-kz8i4a6h	69	5	be	be	VB
cord-006788-kz8i4a6h	69	6	attributed	attribute	VBN
cord-006788-kz8i4a6h	69	7	to	to	IN
cord-006788-kz8i4a6h	69	8	the	the	DT
cord-006788-kz8i4a6h	69	9	loss	loss	NN
cord-006788-kz8i4a6h	69	10	of	of	IN
cord-006788-kz8i4a6h	69	11	the	the	DT
cord-006788-kz8i4a6h	69	12	structurally	structurally	RB
cord-006788-kz8i4a6h	69	13	conserved	conserve	VBN
cord-006788-kz8i4a6h	69	14	HSbinding	hsbinde	VBG
cord-006788-kz8i4a6h	69	15	domain	domain	NN
cord-006788-kz8i4a6h	69	16	characteristic	characteristic	NN
cord-006788-kz8i4a6h	69	17	of	of	IN
cord-006788-kz8i4a6h	69	18	the	the	DT
cord-006788-kz8i4a6h	69	19	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	69	20	FGFs	FGFs	NNPS
cord-006788-kz8i4a6h	69	21	[	[	-LRB-
cord-006788-kz8i4a6h	69	22	5	5	CD
cord-006788-kz8i4a6h	69	23	]	]	-RRB-
cord-006788-kz8i4a6h	69	24	.	.	.
cord-006788-kz8i4a6h	70	1	Both	both	DT
cord-006788-kz8i4a6h	70	2	the	the	DT
cord-006788-kz8i4a6h	70	3	expression	expression	NN
cord-006788-kz8i4a6h	70	4	and	and	CC
cord-006788-kz8i4a6h	70	5	target	target	NN
cord-006788-kz8i4a6h	70	6	tissues	tissue	NNS
cord-006788-kz8i4a6h	70	7	of	of	IN
cord-006788-kz8i4a6h	70	8	the	the	DT
cord-006788-kz8i4a6h	70	9	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	70	10	FGFs	fgf	NNS
cord-006788-kz8i4a6h	70	11	are	be	VBP
cord-006788-kz8i4a6h	70	12	relatively	relatively	RB
cord-006788-kz8i4a6h	70	13	limited	limited	JJ
cord-006788-kz8i4a6h	70	14	to	to	IN
cord-006788-kz8i4a6h	70	15	the	the	DT
cord-006788-kz8i4a6h	70	16	metabolically	metabolically	RB
cord-006788-kz8i4a6h	70	17	active	active	JJ
cord-006788-kz8i4a6h	70	18	endocrine	endocrine	JJ
cord-006788-kz8i4a6h	70	19	organs	organ	NNS
cord-006788-kz8i4a6h	70	20	,	,	,
cord-006788-kz8i4a6h	70	21	such	such	JJ
cord-006788-kz8i4a6h	70	22	as	as	IN
cord-006788-kz8i4a6h	70	23	liver	liver	NN
cord-006788-kz8i4a6h	70	24	,	,	,
cord-006788-kz8i4a6h	70	25	intestine	intestine	NN
cord-006788-kz8i4a6h	70	26	,	,	,
cord-006788-kz8i4a6h	70	27	adipose	adipose	JJ
cord-006788-kz8i4a6h	70	28	tissue	tissue	NN
cord-006788-kz8i4a6h	70	29	,	,	,
cord-006788-kz8i4a6h	70	30	pancreas	pancreas	NN
cord-006788-kz8i4a6h	70	31	,	,	,
cord-006788-kz8i4a6h	70	32	muscle	muscle	NN
cord-006788-kz8i4a6h	70	33	,	,	,
cord-006788-kz8i4a6h	70	34	bone	bone	NN
cord-006788-kz8i4a6h	70	35	,	,	,
cord-006788-kz8i4a6h	70	36	kidney	kidney	NN
cord-006788-kz8i4a6h	70	37	,	,	,
cord-006788-kz8i4a6h	70	38	heart	heart	NN
cord-006788-kz8i4a6h	70	39	,	,	,
cord-006788-kz8i4a6h	70	40	parathyroid	parathyroid	NN
cord-006788-kz8i4a6h	70	41	,	,	,
cord-006788-kz8i4a6h	70	42	and	and	CC
cord-006788-kz8i4a6h	70	43	specific	specific	JJ
cord-006788-kz8i4a6h	70	44	neurons	neuron	NNS
cord-006788-kz8i4a6h	70	45	in	in	IN
cord-006788-kz8i4a6h	70	46	specific	specific	JJ
cord-006788-kz8i4a6h	70	47	regions	region	NNS
cord-006788-kz8i4a6h	70	48	of	of	IN
cord-006788-kz8i4a6h	70	49	the	the	DT
cord-006788-kz8i4a6h	70	50	central	central	JJ
cord-006788-kz8i4a6h	70	51	nervous	nervous	JJ
cord-006788-kz8i4a6h	70	52	system	system	NN
cord-006788-kz8i4a6h	70	53	(	(	-LRB-
cord-006788-kz8i4a6h	70	54	CNS	CNS	NNP
cord-006788-kz8i4a6h	70	55	)	)	-RRB-
cord-006788-kz8i4a6h	71	1	[	[	-LRB-
cord-006788-kz8i4a6h	71	2	55	55	CD
cord-006788-kz8i4a6h	71	3	,	,	,
cord-006788-kz8i4a6h	71	4	56	56	CD
cord-006788-kz8i4a6h	71	5	]	]	-RRB-
cord-006788-kz8i4a6h	71	6	.	.	.
cord-006788-kz8i4a6h	72	1	In	in	IN
cord-006788-kz8i4a6h	72	2	expression	expression	NN
cord-006788-kz8i4a6h	72	3	tissues	tissue	NNS
cord-006788-kz8i4a6h	72	4	,	,	,
cord-006788-kz8i4a6h	72	5	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	72	6	FGF	FGF	NNP
cord-006788-kz8i4a6h	72	7	genes	gene	NNS
cord-006788-kz8i4a6h	72	8	are	be	VBP
cord-006788-kz8i4a6h	72	9	subject	subject	JJ
cord-006788-kz8i4a6h	72	10	to	to	IN
cord-006788-kz8i4a6h	72	11	direct	direct	JJ
cord-006788-kz8i4a6h	72	12	transcriptional	transcriptional	JJ
cord-006788-kz8i4a6h	72	13	control	control	NN
cord-006788-kz8i4a6h	72	14	by	by	IN
cord-006788-kz8i4a6h	72	15	several	several	JJ
cord-006788-kz8i4a6h	72	16	major	major	JJ
cord-006788-kz8i4a6h	72	17	metabolite	metabolite	NN
cord-006788-kz8i4a6h	72	18	-	-	HYPH
cord-006788-kz8i4a6h	72	19	responsive	responsive	JJ
cord-006788-kz8i4a6h	72	20	nuclear	nuclear	JJ
cord-006788-kz8i4a6h	72	21	receptors	receptor	NNS
cord-006788-kz8i4a6h	72	22	,	,	,
cord-006788-kz8i4a6h	72	23	including	include	VBG
cord-006788-kz8i4a6h	72	24	farnesoid	farnesoid	NNP
cord-006788-kz8i4a6h	72	25	X	x	NN
cord-006788-kz8i4a6h	72	26	receptor	receptor	NN
cord-006788-kz8i4a6h	72	27	(	(	-LRB-
cord-006788-kz8i4a6h	72	28	FXR	FXR	NNP
cord-006788-kz8i4a6h	72	29	)	)	-RRB-
cord-006788-kz8i4a6h	72	30	,	,	,
cord-006788-kz8i4a6h	72	31	peroxisome	peroxisome	NN
cord-006788-kz8i4a6h	72	32	proliferator	proliferator	NN
cord-006788-kz8i4a6h	72	33	-	-	HYPH
cord-006788-kz8i4a6h	72	34	activated	activate	VBN
cord-006788-kz8i4a6h	72	35	receptor	receptor	NN
cord-006788-kz8i4a6h	72	36	α	α	NN
cord-006788-kz8i4a6h	72	37	(	(	-LRB-
cord-006788-kz8i4a6h	72	38	PPARA	PPARA	NNP
cord-006788-kz8i4a6h	72	39	)	)	-RRB-
cord-006788-kz8i4a6h	72	40	and	and	CC
cord-006788-kz8i4a6h	72	41	γ	γ	NN
cord-006788-kz8i4a6h	72	42	(	(	-LRB-
cord-006788-kz8i4a6h	72	43	PPARG	PPARG	NNP
cord-006788-kz8i4a6h	72	44	)	)	-RRB-
cord-006788-kz8i4a6h	72	45	,	,	,
cord-006788-kz8i4a6h	72	46	carbohydrate	carbohydrate	NN
cord-006788-kz8i4a6h	72	47	-	-	HYPH
cord-006788-kz8i4a6h	72	48	response	response	NN
cord-006788-kz8i4a6h	72	49	element	element	NN
cord-006788-kz8i4a6h	72	50	-	-	HYPH
cord-006788-kz8i4a6h	72	51	binding	bind	VBG
cord-006788-kz8i4a6h	72	52	protein	protein	NN
cord-006788-kz8i4a6h	72	53	(	(	-LRB-
cord-006788-kz8i4a6h	72	54	Ch	Ch	NNP
cord-006788-kz8i4a6h	72	55	-	-	HYPH
cord-006788-kz8i4a6h	72	56	REBP	REBP	NNP
cord-006788-kz8i4a6h	72	57	)	)	-RRB-
cord-006788-kz8i4a6h	72	58	,	,	,
cord-006788-kz8i4a6h	72	59	sterol	sterol	NN
cord-006788-kz8i4a6h	72	60	regulatory	regulatory	JJ
cord-006788-kz8i4a6h	72	61	element	element	NN
cord-006788-kz8i4a6h	72	62	-	-	HYPH
cord-006788-kz8i4a6h	72	63	binding	bind	VBG
cord-006788-kz8i4a6h	72	64	protein-1c	protein-1c	NNP
cord-006788-kz8i4a6h	72	65	(	(	-LRB-
cord-006788-kz8i4a6h	72	66	SREBP1c	SREBP1c	NNP
cord-006788-kz8i4a6h	72	67	)	)	-RRB-
cord-006788-kz8i4a6h	72	68	,	,	,
cord-006788-kz8i4a6h	72	69	retinoic	retinoic	JJ
cord-006788-kz8i4a6h	72	70	acid	acid	NN
cord-006788-kz8i4a6h	72	71	-	-	HYPH
cord-006788-kz8i4a6h	72	72	related	relate	VBN
cord-006788-kz8i4a6h	72	73	orphan	orphan	NN
cord-006788-kz8i4a6h	72	74	receptor	receptor	NN
cord-006788-kz8i4a6h	72	75	α	α	NN
cord-006788-kz8i4a6h	72	76	(	(	-LRB-
cord-006788-kz8i4a6h	72	77	RORA	RORA	NNP
cord-006788-kz8i4a6h	72	78	)	)	-RRB-
cord-006788-kz8i4a6h	72	79	,	,	,
cord-006788-kz8i4a6h	72	80	liver	liver	NN
cord-006788-kz8i4a6h	72	81	X	x	NN
cord-006788-kz8i4a6h	72	82	receptor	receptor	NN
cord-006788-kz8i4a6h	72	83	β	β	NN
cord-006788-kz8i4a6h	72	84	(	(	-LRB-
cord-006788-kz8i4a6h	72	85	LXRB	LXRB	NNP
cord-006788-kz8i4a6h	72	86	)	)	-RRB-
cord-006788-kz8i4a6h	72	87	,	,	,
cord-006788-kz8i4a6h	72	88	vitamin	vitamin	NN
cord-006788-kz8i4a6h	72	89	D	d	NN
cord-006788-kz8i4a6h	72	90	receptor	receptor	NN
cord-006788-kz8i4a6h	72	91	(	(	-LRB-
cord-006788-kz8i4a6h	72	92	VDR	VDR	NNP
cord-006788-kz8i4a6h	72	93	)	)	-RRB-
cord-006788-kz8i4a6h	72	94	[	[	-LRB-
cord-006788-kz8i4a6h	72	95	48	48	CD
cord-006788-kz8i4a6h	72	96	]	]	-RRB-
cord-006788-kz8i4a6h	73	1	[	[	-LRB-
cord-006788-kz8i4a6h	73	2	49	49	CD
cord-006788-kz8i4a6h	73	3	]	]	-RRB-
cord-006788-kz8i4a6h	73	4	[	[	-LRB-
cord-006788-kz8i4a6h	73	5	50	50	CD
cord-006788-kz8i4a6h	73	6	]	]	-RRB-
cord-006788-kz8i4a6h	73	7	[	[	-LRB-
cord-006788-kz8i4a6h	73	8	57	57	CD
cord-006788-kz8i4a6h	73	9	]	]	-RRB-
cord-006788-kz8i4a6h	74	1	[	[	-LRB-
cord-006788-kz8i4a6h	74	2	58	58	CD
cord-006788-kz8i4a6h	74	3	]	]	-RRB-
cord-006788-kz8i4a6h	75	1	[	[	-LRB-
cord-006788-kz8i4a6h	75	2	59	59	CD
cord-006788-kz8i4a6h	75	3	]	]	-RRB-
cord-006788-kz8i4a6h	75	4	[	[	-LRB-
cord-006788-kz8i4a6h	75	5	60	60	CD
cord-006788-kz8i4a6h	75	6	]	]	-RRB-
cord-006788-kz8i4a6h	75	7	[	[	-LRB-
cord-006788-kz8i4a6h	75	8	61	61	CD
cord-006788-kz8i4a6h	75	9	]	]	-RRB-
cord-006788-kz8i4a6h	76	1	[	[	-LRB-
cord-006788-kz8i4a6h	76	2	62	62	CD
cord-006788-kz8i4a6h	76	3	]	]	-RRB-
cord-006788-kz8i4a6h	76	4	[	[	-LRB-
cord-006788-kz8i4a6h	76	5	63	63	CD
cord-006788-kz8i4a6h	76	6	]	]	-RRB-
cord-006788-kz8i4a6h	77	1	[	[	-LRB-
cord-006788-kz8i4a6h	77	2	64	64	CD
cord-006788-kz8i4a6h	77	3	]	]	-RRB-
cord-006788-kz8i4a6h	77	4	[	[	-LRB-
cord-006788-kz8i4a6h	77	5	65	65	CD
cord-006788-kz8i4a6h	77	6	]	]	-RRB-
cord-006788-kz8i4a6h	77	7	,	,	,
cord-006788-kz8i4a6h	77	8	and	and	CC
cord-006788-kz8i4a6h	77	9	stress	stress	NN
cord-006788-kz8i4a6h	77	10	-	-	HYPH
cord-006788-kz8i4a6h	77	11	sensing	sense	VBG
cord-006788-kz8i4a6h	77	12	transcription	transcription	NN
cord-006788-kz8i4a6h	77	13	factors	factor	NNS
cord-006788-kz8i4a6h	77	14	,	,	,
cord-006788-kz8i4a6h	77	15	such	such	JJ
cord-006788-kz8i4a6h	77	16	as	as	IN
cord-006788-kz8i4a6h	77	17	ATF4	ATF4	NNP
cord-006788-kz8i4a6h	77	18	[	[	-LRB-
cord-006788-kz8i4a6h	77	19	66	66	CD
cord-006788-kz8i4a6h	77	20	]	]	-RRB-
cord-006788-kz8i4a6h	77	21	,	,	,
cord-006788-kz8i4a6h	77	22	depending	depend	VBG
cord-006788-kz8i4a6h	77	23	on	on	IN
cord-006788-kz8i4a6h	77	24	the	the	DT
cord-006788-kz8i4a6h	77	25	location	location	NN
cord-006788-kz8i4a6h	77	26	of	of	IN
cord-006788-kz8i4a6h	77	27	specific	specific	JJ
cord-006788-kz8i4a6h	77	28	nutrition	nutrition	NN
cord-006788-kz8i4a6h	77	29	/	/	SYM
cord-006788-kz8i4a6h	77	30	energy	energy	NN
cord-006788-kz8i4a6h	77	31	-	-	HYPH
cord-006788-kz8i4a6h	77	32	sensing	sense	VBG
cord-006788-kz8i4a6h	77	33	cells	cell	NNS
cord-006788-kz8i4a6h	77	34	in	in	IN
cord-006788-kz8i4a6h	77	35	specific	specific	JJ
cord-006788-kz8i4a6h	77	36	tissues	tissue	NNS
cord-006788-kz8i4a6h	77	37	.	.	.
cord-006788-kz8i4a6h	78	1	In	in	IN
cord-006788-kz8i4a6h	78	2	target	target	NN
cord-006788-kz8i4a6h	78	3	tissues	tissue	NNS
cord-006788-kz8i4a6h	78	4	,	,	,
cord-006788-kz8i4a6h	78	5	the	the	DT
cord-006788-kz8i4a6h	78	6	biological	biological	JJ
cord-006788-kz8i4a6h	78	7	effects	effect	NNS
cord-006788-kz8i4a6h	78	8	of	of	IN
cord-006788-kz8i4a6h	78	9	the	the	DT
cord-006788-kz8i4a6h	78	10	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	78	11	FGF	FGF	NNP
cord-006788-kz8i4a6h	78	12	axes	axis	NNS
cord-006788-kz8i4a6h	78	13	are	be	VBP
cord-006788-kz8i4a6h	78	14	still	still	RB
cord-006788-kz8i4a6h	78	15	mediated	mediate	VBN
cord-006788-kz8i4a6h	78	16	by	by	IN
cord-006788-kz8i4a6h	78	17	FGFRs	fgfr	NNS
cord-006788-kz8i4a6h	78	18	but	but	CC
cord-006788-kz8i4a6h	78	19	in	in	IN
cord-006788-kz8i4a6h	78	20	a	a	DT
cord-006788-kz8i4a6h	78	21	different	different	JJ
cord-006788-kz8i4a6h	78	22	binary	binary	JJ
cord-006788-kz8i4a6h	78	23	complex	complex	NN
cord-006788-kz8i4a6h	78	24	with	with	IN
cord-006788-kz8i4a6h	78	25	a	a	DT
cord-006788-kz8i4a6h	78	26	new	new	JJ
cord-006788-kz8i4a6h	78	27	transmembrane	transmembrane	NNP
cord-006788-kz8i4a6h	78	28	nonkinase	nonkinase	NNP
cord-006788-kz8i4a6h	78	29	accessory	accessory	NNP
cord-006788-kz8i4a6h	78	30	coreceptor	coreceptor	NNP
cord-006788-kz8i4a6h	78	31	,	,	,
cord-006788-kz8i4a6h	78	32	the	the	DT
cord-006788-kz8i4a6h	78	33	α	α	NNP
cord-006788-kz8i4a6h	78	34	-	-	HYPH
cord-006788-kz8i4a6h	78	35	Klotho	Klotho	NNP
cord-006788-kz8i4a6h	78	36	(	(	-LRB-
cord-006788-kz8i4a6h	78	37	KL	KL	NNP
cord-006788-kz8i4a6h	78	38	)	)	-RRB-
cord-006788-kz8i4a6h	78	39	or	or	CC
cord-006788-kz8i4a6h	78	40	β	β	NN
cord-006788-kz8i4a6h	78	41	-	-	HYPH
cord-006788-kz8i4a6h	78	42	KL	KL	NNP
cord-006788-kz8i4a6h	78	43	(	(	-LRB-
cord-006788-kz8i4a6h	78	44	KLB	KLB	NNP
cord-006788-kz8i4a6h	78	45	)	)	-RRB-
cord-006788-kz8i4a6h	78	46	[	[	-LRB-
cord-006788-kz8i4a6h	78	47	5	5	CD
cord-006788-kz8i4a6h	78	48	,	,	,
cord-006788-kz8i4a6h	78	49	11	11	CD
cord-006788-kz8i4a6h	78	50	,	,	,
cord-006788-kz8i4a6h	78	51	55	55	CD
cord-006788-kz8i4a6h	78	52	,	,	,
cord-006788-kz8i4a6h	78	53	67	67	CD
cord-006788-kz8i4a6h	78	54	]	]	-RRB-
cord-006788-kz8i4a6h	78	55	(	(	-LRB-
cord-006788-kz8i4a6h	78	56	Table	table	NN
cord-006788-kz8i4a6h	78	57	2	2	CD
cord-006788-kz8i4a6h	78	58	)	)	-RRB-
cord-006788-kz8i4a6h	78	59	,	,	,
cord-006788-kz8i4a6h	78	60	to	to	TO
cord-006788-kz8i4a6h	78	61	which	which	WDT
cord-006788-kz8i4a6h	78	62	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	78	63	FGFs	fgf	NNS
cord-006788-kz8i4a6h	78	64	do	do	VBP
cord-006788-kz8i4a6h	78	65	not	not	RB
cord-006788-kz8i4a6h	78	66	bind	bind	VB
cord-006788-kz8i4a6h	78	67	.	.	.
cord-006788-kz8i4a6h	79	1	Structurally	structurally	RB
cord-006788-kz8i4a6h	79	2	,	,	,
cord-006788-kz8i4a6h	79	3	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	79	4	FGFs	fgf	NNS
cord-006788-kz8i4a6h	79	5	coevolve	coevolve	RB
cord-006788-kz8i4a6h	79	6	with	with	IN
cord-006788-kz8i4a6h	79	7	coreceptor	coreceptor	NN
cord-006788-kz8i4a6h	79	8	KL	KL	NNP
cord-006788-kz8i4a6h	79	9	/	/	SYM
cord-006788-kz8i4a6h	79	10	KLB	KLB	NNP
cord-006788-kz8i4a6h	79	11	but	but	CC
cord-006788-kz8i4a6h	79	12	also	also	RB
cord-006788-kz8i4a6h	79	13	acquire	acquire	VBP
cord-006788-kz8i4a6h	79	14	new	new	JJ
cord-006788-kz8i4a6h	79	15	structural	structural	JJ
cord-006788-kz8i4a6h	79	16	elements	element	NNS
cord-006788-kz8i4a6h	79	17	that	that	WDT
cord-006788-kz8i4a6h	79	18	direct	direct	VBP
cord-006788-kz8i4a6h	79	19	specific	specific	JJ
cord-006788-kz8i4a6h	79	20	contact	contact	NN
cord-006788-kz8i4a6h	79	21	interactions	interaction	NNS
cord-006788-kz8i4a6h	79	22	with	with	IN
cord-006788-kz8i4a6h	79	23	KL	KL	NNP
cord-006788-kz8i4a6h	79	24	/	/	SYM
cord-006788-kz8i4a6h	79	25	KLB	KLB	NNP
cord-006788-kz8i4a6h	79	26	and	and	CC
cord-006788-kz8i4a6h	79	27	FGFRs	fgfr	NNS
cord-006788-kz8i4a6h	79	28	,	,	,
cord-006788-kz8i4a6h	79	29	thereby	thereby	RB
cord-006788-kz8i4a6h	79	30	leading	lead	VBG
cord-006788-kz8i4a6h	79	31	to	to	IN
cord-006788-kz8i4a6h	79	32	a	a	DT
cord-006788-kz8i4a6h	79	33	tethered	tethered	JJ
cord-006788-kz8i4a6h	79	34	basic	basic	JJ
cord-006788-kz8i4a6h	79	35	triad	triad	NN
cord-006788-kz8i4a6h	79	36	complex	complex	JJ
cord-006788-kz8i4a6h	79	37	and	and	CC
cord-006788-kz8i4a6h	79	38	subsequent	subsequent	JJ
cord-006788-kz8i4a6h	79	39	activation	activation	NN
cord-006788-kz8i4a6h	79	40	of	of	IN
cord-006788-kz8i4a6h	79	41	intracellular	intracellular	JJ
cord-006788-kz8i4a6h	79	42	kinase	kinase	NN
cord-006788-kz8i4a6h	79	43	domains	domain	NNS
cord-006788-kz8i4a6h	79	44	of	of	IN
cord-006788-kz8i4a6h	79	45	FGFRs	fgfr	NNS
cord-006788-kz8i4a6h	79	46	[	[	-LRB-
cord-006788-kz8i4a6h	79	47	5	5	CD
cord-006788-kz8i4a6h	79	48	,	,	,
cord-006788-kz8i4a6h	79	49	11	11	CD
cord-006788-kz8i4a6h	79	50	]	]	-RRB-
cord-006788-kz8i4a6h	79	51	.	.	.
cord-006788-kz8i4a6h	80	1	The	the	DT
cord-006788-kz8i4a6h	80	2	C	c	NN
cord-006788-kz8i4a6h	80	3	-	-	HYPH
cord-006788-kz8i4a6h	80	4	terminus	terminus	NN
cord-006788-kz8i4a6h	80	5	of	of	IN
cord-006788-kz8i4a6h	80	6	the	the	DT
cord-006788-kz8i4a6h	80	7	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	80	8	FGFs	fgf	NNS
cord-006788-kz8i4a6h	80	9	mimics	mimic	VBZ
cord-006788-kz8i4a6h	80	10	the	the	DT
cord-006788-kz8i4a6h	80	11	interaction	interaction	NN
cord-006788-kz8i4a6h	80	12	mode	mode	NN
cord-006788-kz8i4a6h	80	13	of	of	IN
cord-006788-kz8i4a6h	80	14	a	a	DT
cord-006788-kz8i4a6h	80	15	sugar	sugar	NN
cord-006788-kz8i4a6h	80	16	chain	chain	NN
cord-006788-kz8i4a6h	80	17	that	that	WDT
cord-006788-kz8i4a6h	80	18	docks	dock	VBZ
cord-006788-kz8i4a6h	80	19	into	into	IN
cord-006788-kz8i4a6h	80	20	the	the	DT
cord-006788-kz8i4a6h	80	21	pseudo	pseudo	JJ
cord-006788-kz8i4a6h	80	22	-	-	HYPH
cord-006788-kz8i4a6h	80	23	glycolytic	glycolytic	JJ
cord-006788-kz8i4a6h	80	24	pocket	pocket	NN
cord-006788-kz8i4a6h	80	25	of	of	IN
cord-006788-kz8i4a6h	80	26	KL	KL	NNP
cord-006788-kz8i4a6h	80	27	/	/	SYM
cord-006788-kz8i4a6h	80	28	KLB	KLB	NNP
cord-006788-kz8i4a6h	80	29	while	while	IN
cord-006788-kz8i4a6h	80	30	interacting	interact	VBG
cord-006788-kz8i4a6h	80	31	with	with	IN
cord-006788-kz8i4a6h	80	32	FGFR	FGFR	NNP
cord-006788-kz8i4a6h	80	33	ectodomains	ectodomain	NNS
cord-006788-kz8i4a6h	80	34	through	through	IN
cord-006788-kz8i4a6h	80	35	the	the	DT
cord-006788-kz8i4a6h	80	36	domains	domain	NNS
cord-006788-kz8i4a6h	80	37	that	that	WDT
cord-006788-kz8i4a6h	80	38	are	be	VBP
cord-006788-kz8i4a6h	80	39	conserved	conserve	VBN
cord-006788-kz8i4a6h	80	40	across	across	IN
cord-006788-kz8i4a6h	80	41	the	the	DT
cord-006788-kz8i4a6h	80	42	FGF	FGF	NNP
cord-006788-kz8i4a6h	80	43	family	family	NN
cord-006788-kz8i4a6h	80	44	[	[	-LRB-
cord-006788-kz8i4a6h	80	45	5	5	CD
cord-006788-kz8i4a6h	80	46	,	,	,
cord-006788-kz8i4a6h	80	47	68	68	CD
cord-006788-kz8i4a6h	80	48	]	]	-RRB-
cord-006788-kz8i4a6h	80	49	.	.	.
cord-006788-kz8i4a6h	81	1	Meanwhile	meanwhile	RB
cord-006788-kz8i4a6h	81	2	,	,	,
cord-006788-kz8i4a6h	81	3	the	the	DT
cord-006788-kz8i4a6h	81	4	interacting	interact	VBG
cord-006788-kz8i4a6h	81	5	KL	KL	NNP
cord-006788-kz8i4a6h	81	6	/	/	SYM
cord-006788-kz8i4a6h	81	7	KLB	KLB	NNP
cord-006788-kz8i4a6h	81	8	protrudes	protrude	VBZ
cord-006788-kz8i4a6h	81	9	an	an	DT
cord-006788-kz8i4a6h	81	10	"	"	``
cord-006788-kz8i4a6h	81	11	arm	arm	NN
cord-006788-kz8i4a6h	81	12	"	"	''
cord-006788-kz8i4a6h	81	13	from	from	IN
cord-006788-kz8i4a6h	81	14	the	the	DT
cord-006788-kz8i4a6h	81	15	membrane	membrane	NN
cord-006788-kz8i4a6h	81	16	-	-	HYPH
cord-006788-kz8i4a6h	81	17	proximal	proximal	JJ
cord-006788-kz8i4a6h	81	18	glycosidase	glycosidase	NN
cord-006788-kz8i4a6h	81	19	domain	domain	NN
cord-006788-kz8i4a6h	81	20	griping	gripe	VBG
cord-006788-kz8i4a6h	81	21	onto	onto	IN
cord-006788-kz8i4a6h	81	22	the	the	DT
cord-006788-kz8i4a6h	81	23	FGFR	FGFR	NNP
cord-006788-kz8i4a6h	81	24	ectodomain	ectodomain	NN
cord-006788-kz8i4a6h	81	25	.	.	.
cord-006788-kz8i4a6h	82	1	Although	although	IN
cord-006788-kz8i4a6h	82	2	the	the	DT
cord-006788-kz8i4a6h	82	3	FGFRs	fgfr	NNS
cord-006788-kz8i4a6h	82	4	,	,	,
cord-006788-kz8i4a6h	82	5	in	in	IN
cord-006788-kz8i4a6h	82	6	particular	particular	JJ
cord-006788-kz8i4a6h	82	7	FGFR1	FGFR1	NNP
cord-006788-kz8i4a6h	82	8	,	,	,
cord-006788-kz8i4a6h	82	9	are	be	VBP
cord-006788-kz8i4a6h	82	10	broadly	broadly	RB
cord-006788-kz8i4a6h	82	11	expressed	express	VBN
cord-006788-kz8i4a6h	82	12	,	,	,
cord-006788-kz8i4a6h	82	13	the	the	DT
cord-006788-kz8i4a6h	82	14	highly	highly	RB
cord-006788-kz8i4a6h	82	15	restricted	restricted	JJ
cord-006788-kz8i4a6h	82	16	expression	expression	NN
cord-006788-kz8i4a6h	82	17	of	of	IN
cord-006788-kz8i4a6h	82	18	KL	KL	NNP
cord-006788-kz8i4a6h	82	19	/	/	SYM
cord-006788-kz8i4a6h	82	20	KLB	KLB	NNP
cord-006788-kz8i4a6h	82	21	and	and	CC
cord-006788-kz8i4a6h	82	22	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	82	23	FGFs	fgf	NNS
cord-006788-kz8i4a6h	82	24	,	,	,
cord-006788-kz8i4a6h	82	25	and	and	CC
cord-006788-kz8i4a6h	82	26	the	the	DT
cord-006788-kz8i4a6h	82	27	new	new	JJ
cord-006788-kz8i4a6h	82	28	structural	structural	JJ
cord-006788-kz8i4a6h	82	29	elements	element	NNS
cord-006788-kz8i4a6h	82	30	and	and	CC
cord-006788-kz8i4a6h	82	31	mutual	mutual	JJ
cord-006788-kz8i4a6h	82	32	interaction	interaction	NN
cord-006788-kz8i4a6h	82	33	modes	mode	NNS
cord-006788-kz8i4a6h	82	34	,	,	,
cord-006788-kz8i4a6h	82	35	set	set	VBD
cord-006788-kz8i4a6h	82	36	the	the	DT
cord-006788-kz8i4a6h	82	37	tone	tone	NN
cord-006788-kz8i4a6h	82	38	for	for	IN
cord-006788-kz8i4a6h	82	39	tissue	tissue	NN
cord-006788-kz8i4a6h	82	40	-	-	HYPH
cord-006788-kz8i4a6h	82	41	specific	specific	JJ
cord-006788-kz8i4a6h	82	42	functions	function	NNS
cord-006788-kz8i4a6h	82	43	of	of	IN
cord-006788-kz8i4a6h	82	44	the	the	DT
cord-006788-kz8i4a6h	82	45	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	82	46	FGF	FGF	NNP
cord-006788-kz8i4a6h	82	47	axes	axis	NNS
cord-006788-kz8i4a6h	82	48	(	(	-LRB-
cord-006788-kz8i4a6h	82	49	Table	table	NN
cord-006788-kz8i4a6h	82	50	2	2	CD
cord-006788-kz8i4a6h	82	51	)	)	-RRB-
cord-006788-kz8i4a6h	82	52	.	.	.
cord-006788-kz8i4a6h	83	1	The	the	DT
cord-006788-kz8i4a6h	83	2	different	different	JJ
cord-006788-kz8i4a6h	83	3	intracellular	intracellular	JJ
cord-006788-kz8i4a6h	83	4	molecular	molecular	JJ
cord-006788-kz8i4a6h	83	5	constituents	constituent	NNS
cord-006788-kz8i4a6h	83	6	in	in	IN
cord-006788-kz8i4a6h	83	7	different	different	JJ
cord-006788-kz8i4a6h	83	8	cells	cell	NNS
cord-006788-kz8i4a6h	83	9	types	type	NNS
cord-006788-kz8i4a6h	83	10	,	,	,
cord-006788-kz8i4a6h	83	11	which	which	WDT
cord-006788-kz8i4a6h	83	12	are	be	VBP
cord-006788-kz8i4a6h	83	13	tailored	tailor	VBN
cord-006788-kz8i4a6h	83	14	to	to	TO
cord-006788-kz8i4a6h	83	15	perform	perform	VB
cord-006788-kz8i4a6h	83	16	specific	specific	JJ
cord-006788-kz8i4a6h	83	17	biological	biological	JJ
cord-006788-kz8i4a6h	83	18	functions	function	NNS
cord-006788-kz8i4a6h	83	19	,	,	,
cord-006788-kz8i4a6h	83	20	may	may	MD
cord-006788-kz8i4a6h	83	21	be	be	VB
cord-006788-kz8i4a6h	83	22	also	also	RB
cord-006788-kz8i4a6h	83	23	an	an	DT
cord-006788-kz8i4a6h	83	24	important	important	JJ
cord-006788-kz8i4a6h	83	25	limiting	limit	VBG
cord-006788-kz8i4a6h	83	26	factor	factor	NN
cord-006788-kz8i4a6h	83	27	.	.	.
cord-006788-kz8i4a6h	84	1	For	for	IN
cord-006788-kz8i4a6h	84	2	instance	instance	NN
cord-006788-kz8i4a6h	84	3	,	,	,
cord-006788-kz8i4a6h	84	4	the	the	DT
cord-006788-kz8i4a6h	84	5	adult	adult	NN
cord-006788-kz8i4a6h	84	6	adipocytes	adipocyte	NNS
cord-006788-kz8i4a6h	84	7	are	be	VBP
cord-006788-kz8i4a6h	84	8	not	not	RB
cord-006788-kz8i4a6h	84	9	poised	poise	VBN
cord-006788-kz8i4a6h	84	10	in	in	IN
cord-006788-kz8i4a6h	84	11	a	a	DT
cord-006788-kz8i4a6h	84	12	normal	normal	JJ
cord-006788-kz8i4a6h	84	13	context	context	NN
cord-006788-kz8i4a6h	84	14	to	to	TO
cord-006788-kz8i4a6h	84	15	increase	increase	VB
cord-006788-kz8i4a6h	84	16	population	population	NN
cord-006788-kz8i4a6h	84	17	by	by	IN
cord-006788-kz8i4a6h	84	18	direct	direct	JJ
cord-006788-kz8i4a6h	84	19	proliferation	proliferation	NN
cord-006788-kz8i4a6h	84	20	due	due	IN
cord-006788-kz8i4a6h	84	21	to	to	IN
cord-006788-kz8i4a6h	84	22	the	the	DT
cord-006788-kz8i4a6h	84	23	loss	loss	NN
cord-006788-kz8i4a6h	84	24	of	of	IN
cord-006788-kz8i4a6h	84	25	several	several	JJ
cord-006788-kz8i4a6h	84	26	key	key	JJ
cord-006788-kz8i4a6h	84	27	proliferation	proliferation	NN
cord-006788-kz8i4a6h	84	28	-	-	HYPH
cord-006788-kz8i4a6h	84	29	controlling	control	VBG
cord-006788-kz8i4a6h	84	30	pathways	pathway	NNS
cord-006788-kz8i4a6h	84	31	,	,	,
cord-006788-kz8i4a6h	84	32	thereby	thereby	RB
cord-006788-kz8i4a6h	84	33	partly	partly	RB
cord-006788-kz8i4a6h	84	34	accounting	account	VBG
cord-006788-kz8i4a6h	84	35	for	for	IN
cord-006788-kz8i4a6h	84	36	the	the	DT
cord-006788-kz8i4a6h	84	37	inability	inability	NN
cord-006788-kz8i4a6h	84	38	of	of	IN
cord-006788-kz8i4a6h	84	39	the	the	DT
cord-006788-kz8i4a6h	84	40	activated	activate	VBN
cord-006788-kz8i4a6h	84	41	FGFR1	FGFR1	NNP
cord-006788-kz8i4a6h	84	42	by	by	IN
cord-006788-kz8i4a6h	84	43	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	84	44	to	to	TO
cord-006788-kz8i4a6h	84	45	promote	promote	VB
cord-006788-kz8i4a6h	84	46	adipocyte	adipocyte	NN
cord-006788-kz8i4a6h	84	47	proliferation	proliferation	NN
cord-006788-kz8i4a6h	84	48	.	.	.
cord-006788-kz8i4a6h	85	1	Overall	overall	RB
cord-006788-kz8i4a6h	85	2	,	,	,
cord-006788-kz8i4a6h	85	3	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	85	4	FGFs	fgf	NNS
cord-006788-kz8i4a6h	85	5	appear	appear	VBP
cord-006788-kz8i4a6h	85	6	to	to	TO
cord-006788-kz8i4a6h	85	7	be	be	VB
cord-006788-kz8i4a6h	85	8	inducible	inducible	JJ
cord-006788-kz8i4a6h	85	9	stress	stress	NN
cord-006788-kz8i4a6h	85	10	factors	factor	NNS
cord-006788-kz8i4a6h	85	11	in	in	IN
cord-006788-kz8i4a6h	85	12	response	response	NN
cord-006788-kz8i4a6h	85	13	to	to	IN
cord-006788-kz8i4a6h	85	14	organismal	organismal	JJ
cord-006788-kz8i4a6h	85	15	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	85	16	perturbations	perturbation	NNS
cord-006788-kz8i4a6h	85	17	[	[	-LRB-
cord-006788-kz8i4a6h	85	18	7,69	7,69	CD
cord-006788-kz8i4a6h	85	19	]	]	-RRB-
cord-006788-kz8i4a6h	85	20	and	and	CC
cord-006788-kz8i4a6h	85	21	signal	signal	VB
cord-006788-kz8i4a6h	85	22	distal	distal	JJ
cord-006788-kz8i4a6h	85	23	peripheral	peripheral	JJ
cord-006788-kz8i4a6h	85	24	tissues	tissue	NNS
cord-006788-kz8i4a6h	85	25	through	through	IN
cord-006788-kz8i4a6h	85	26	the	the	DT
cord-006788-kz8i4a6h	85	27	FGFR	FGFR	NNP
cord-006788-kz8i4a6h	85	28	-	-	HYPH
cord-006788-kz8i4a6h	85	29	KL	KL	NNP
cord-006788-kz8i4a6h	85	30	/	/	SYM
cord-006788-kz8i4a6h	85	31	KLB	KLB	NNP
cord-006788-kz8i4a6h	85	32	complex	complex	JJ
cord-006788-kz8i4a6h	85	33	to	to	TO
cord-006788-kz8i4a6h	85	34	control	control	VB
cord-006788-kz8i4a6h	85	35	due	due	JJ
cord-006788-kz8i4a6h	85	36	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	85	37	pathways	pathway	NNS
cord-006788-kz8i4a6h	85	38	.	.	.
cord-006788-kz8i4a6h	86	1	In	in	IN
cord-006788-kz8i4a6h	86	2	this	this	DT
cord-006788-kz8i4a6h	86	3	sense	sense	NN
cord-006788-kz8i4a6h	86	4	,	,	,
cord-006788-kz8i4a6h	86	5	the	the	DT
cord-006788-kz8i4a6h	86	6	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	86	7	FGF	FGF	NNP
cord-006788-kz8i4a6h	86	8	acts	act	VBZ
cord-006788-kz8i4a6h	86	9	as	as	IN
cord-006788-kz8i4a6h	86	10	a	a	DT
cord-006788-kz8i4a6h	86	11	key	key	NN
cord-006788-kz8i4a6h	86	12	to	to	TO
cord-006788-kz8i4a6h	86	13	ignite	ignite	VB
cord-006788-kz8i4a6h	86	14	the	the	DT
cord-006788-kz8i4a6h	86	15	FGF	FGF	NNP
cord-006788-kz8i4a6h	86	16	-	-	HYPH
cord-006788-kz8i4a6h	86	17	FGFR	FGFR	NNP
cord-006788-kz8i4a6h	86	18	-	-	HYPH
cord-006788-kz8i4a6h	86	19	KLB	KLB	NNP
cord-006788-kz8i4a6h	86	20	/	/	SYM
cord-006788-kz8i4a6h	86	21	KLB	KLB	NNP
cord-006788-kz8i4a6h	86	22	triad	triad	NN
cord-006788-kz8i4a6h	86	23	complex	complex	NN
cord-006788-kz8i4a6h	86	24	,	,	,
cord-006788-kz8i4a6h	86	25	which	which	WDT
cord-006788-kz8i4a6h	86	26	functions	function	VBZ
cord-006788-kz8i4a6h	86	27	similarly	similarly	RB
cord-006788-kz8i4a6h	86	28	as	as	IN
cord-006788-kz8i4a6h	86	29	an	an	DT
cord-006788-kz8i4a6h	86	30	engine	engine	NN
cord-006788-kz8i4a6h	86	31	with	with	IN
cord-006788-kz8i4a6h	86	32	an	an	DT
cord-006788-kz8i4a6h	86	33	axis	axis	NN
cord-006788-kz8i4a6h	86	34	to	to	TO
cord-006788-kz8i4a6h	86	35	drive	drive	VB
cord-006788-kz8i4a6h	86	36	effects	effect	NNS
cord-006788-kz8i4a6h	86	37	in	in	IN
cord-006788-kz8i4a6h	86	38	a	a	DT
cord-006788-kz8i4a6h	86	39	tissue	tissue	NN
cord-006788-kz8i4a6h	86	40	-	-	HYPH
cord-006788-kz8i4a6h	86	41	specific	specific	JJ
cord-006788-kz8i4a6h	86	42	manner	manner	NN
cord-006788-kz8i4a6h	86	43	,	,	,
cord-006788-kz8i4a6h	86	44	thereby	thereby	RB
cord-006788-kz8i4a6h	86	45	leading	lead	VBG
cord-006788-kz8i4a6h	86	46	to	to	IN
cord-006788-kz8i4a6h	86	47	beneficial	beneficial	JJ
cord-006788-kz8i4a6h	86	48	effects	effect	NNS
cord-006788-kz8i4a6h	86	49	that	that	WDT
cord-006788-kz8i4a6h	86	50	offset	offset	VBP
cord-006788-kz8i4a6h	86	51	the	the	DT
cord-006788-kz8i4a6h	86	52	initial	initial	JJ
cord-006788-kz8i4a6h	86	53	adverse	adverse	JJ
cord-006788-kz8i4a6h	86	54	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	86	55	changes	change	NNS
cord-006788-kz8i4a6h	86	56	and	and	CC
cord-006788-kz8i4a6h	86	57	prevent	prevent	VB
cord-006788-kz8i4a6h	86	58	metaflammation	metaflammation	NN
cord-006788-kz8i4a6h	86	59	and	and	CC
cord-006788-kz8i4a6h	86	60	tissue	tissue	NN
cord-006788-kz8i4a6h	86	61	damage	damage	NN
cord-006788-kz8i4a6h	86	62	not	not	RB
cord-006788-kz8i4a6h	86	63	only	only	RB
cord-006788-kz8i4a6h	86	64	in	in	IN
cord-006788-kz8i4a6h	86	65	the	the	DT
cord-006788-kz8i4a6h	86	66	FGF	FGF	NNP
cord-006788-kz8i4a6h	86	67	-	-	HYPH
cord-006788-kz8i4a6h	86	68	producing	produce	VBG
cord-006788-kz8i4a6h	86	69	tissues	tissue	NNS
cord-006788-kz8i4a6h	86	70	but	but	CC
cord-006788-kz8i4a6h	86	71	also	also	RB
cord-006788-kz8i4a6h	86	72	systemically	systemically	RB
cord-006788-kz8i4a6h	86	73	[	[	-LRB-
cord-006788-kz8i4a6h	86	74	2	2	CD
cord-006788-kz8i4a6h	86	75	,	,	,
cord-006788-kz8i4a6h	86	76	7	7	CD
cord-006788-kz8i4a6h	86	77	]	]	-RRB-
cord-006788-kz8i4a6h	87	1	(	(	-LRB-
cord-006788-kz8i4a6h	87	2	Table	table	NN
cord-006788-kz8i4a6h	87	3	2	2	CD
cord-006788-kz8i4a6h	87	4	)	)	-RRB-
cord-006788-kz8i4a6h	87	5	.	.	.
cord-006788-kz8i4a6h	88	1	Consequently	consequently	RB
cord-006788-kz8i4a6h	88	2	,	,	,
cord-006788-kz8i4a6h	88	3	both	both	CC
cord-006788-kz8i4a6h	88	4	the	the	DT
cord-006788-kz8i4a6h	88	5	analogs	analog	NNS
cord-006788-kz8i4a6h	88	6	of	of	IN
cord-006788-kz8i4a6h	88	7	endocrine	endocrine	JJ
cord-006788-kz8i4a6h	88	8	FGFs	fgf	NNS
cord-006788-kz8i4a6h	88	9	and	and	CC
cord-006788-kz8i4a6h	88	10	the	the	DT
cord-006788-kz8i4a6h	88	11	agonists	agonist	NNS
cord-006788-kz8i4a6h	88	12	of	of	IN
cord-006788-kz8i4a6h	88	13	FGF	FGF	NNP
cord-006788-kz8i4a6h	88	14	-	-	HYPH
cord-006788-kz8i4a6h	88	15	KL/	KL/	NNP
cord-006788-kz8i4a6h	88	16	KLB	KLB	NNP
cord-006788-kz8i4a6h	88	17	have	have	VBP
cord-006788-kz8i4a6h	88	18	been	be	VBN
cord-006788-kz8i4a6h	88	19	actively	actively	RB
cord-006788-kz8i4a6h	88	20	pursued	pursue	VBN
cord-006788-kz8i4a6h	88	21	clinically	clinically	RB
cord-006788-kz8i4a6h	88	22	for	for	IN
cord-006788-kz8i4a6h	88	23	the	the	DT
cord-006788-kz8i4a6h	88	24	prevention	prevention	NN
cord-006788-kz8i4a6h	88	25	and	and	CC
cord-006788-kz8i4a6h	88	26	treatment	treatment	NN
cord-006788-kz8i4a6h	88	27	of	of	IN
cord-006788-kz8i4a6h	88	28	a	a	DT
cord-006788-kz8i4a6h	88	29	wide	wide	JJ
cord-006788-kz8i4a6h	88	30	range	range	NN
cord-006788-kz8i4a6h	88	31	of	of	IN
cord-006788-kz8i4a6h	88	32	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	88	33	diseases	disease	NNS
cord-006788-kz8i4a6h	88	34	and	and	CC
cord-006788-kz8i4a6h	88	35	comorbidities	comorbiditie	NNS
cord-006788-kz8i4a6h	88	36	[	[	-LRB-
cord-006788-kz8i4a6h	88	37	2	2	CD
cord-006788-kz8i4a6h	88	38	,	,	,
cord-006788-kz8i4a6h	88	39	[	[	-LRB-
cord-006788-kz8i4a6h	88	40	70	70	CD
cord-006788-kz8i4a6h	88	41	]	]	-RRB-
cord-006788-kz8i4a6h	88	42	[	[	-LRB-
cord-006788-kz8i4a6h	88	43	71	71	CD
cord-006788-kz8i4a6h	88	44	]	]	-RRB-
cord-006788-kz8i4a6h	88	45	[	[	-LRB-
cord-006788-kz8i4a6h	88	46	72	72	CD
cord-006788-kz8i4a6h	88	47	]	]	-RRB-
cord-006788-kz8i4a6h	88	48	[	[	-LRB-
cord-006788-kz8i4a6h	88	49	73	73	CD
cord-006788-kz8i4a6h	88	50	]	]	-RRB-
cord-006788-kz8i4a6h	88	51	[	[	-LRB-
cord-006788-kz8i4a6h	88	52	74	74	CD
cord-006788-kz8i4a6h	88	53	]	]	-RRB-
cord-006788-kz8i4a6h	88	54	[	[	-LRB-
cord-006788-kz8i4a6h	88	55	75	75	CD
cord-006788-kz8i4a6h	88	56	]	]	-RRB-
cord-006788-kz8i4a6h	88	57	.	.	.
cord-006788-kz8i4a6h	88	58	 	 	_SP
cord-006788-kz8i4a6h	89	1	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	89	2	is	be	VBZ
cord-006788-kz8i4a6h	89	3	the	the	DT
cord-006788-kz8i4a6h	89	4	prime	prime	JJ
cord-006788-kz8i4a6h	89	5	controller	controller	NN
cord-006788-kz8i4a6h	89	6	of	of	IN
cord-006788-kz8i4a6h	89	7	diurnal	diurnal	JJ
cord-006788-kz8i4a6h	89	8	bile	bile	NN
cord-006788-kz8i4a6h	89	9	acid	acid	NN
cord-006788-kz8i4a6h	89	10	flux	flux	NN
cord-006788-kz8i4a6h	89	11	,	,	,
cord-006788-kz8i4a6h	89	12	and	and	CC
cord-006788-kz8i4a6h	89	13	the	the	DT
cord-006788-kz8i4a6h	89	14	FGF19-driven	FGF19-driven	NNP
cord-006788-kz8i4a6h	89	15	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	89	16	axis	axis	NN
cord-006788-kz8i4a6h	89	17	is	be	VBZ
cord-006788-kz8i4a6h	89	18	a	a	DT
cord-006788-kz8i4a6h	89	19	temporal	temporal	JJ
cord-006788-kz8i4a6h	89	20	interorgan	interorgan	NN
cord-006788-kz8i4a6h	89	21	crosstalk	crosstalk	NN
cord-006788-kz8i4a6h	89	22	from	from	IN
cord-006788-kz8i4a6h	89	23	the	the	DT
cord-006788-kz8i4a6h	89	24	ileum	ileum	NN
cord-006788-kz8i4a6h	89	25	to	to	IN
cord-006788-kz8i4a6h	89	26	the	the	DT
cord-006788-kz8i4a6h	89	27	liver	liver	NN
cord-006788-kz8i4a6h	89	28	in	in	IN
cord-006788-kz8i4a6h	89	29	response	response	NN
cord-006788-kz8i4a6h	89	30	to	to	IN
cord-006788-kz8i4a6h	89	31	the	the	DT
cord-006788-kz8i4a6h	89	32	increase	increase	NN
cord-006788-kz8i4a6h	89	33	in	in	IN
cord-006788-kz8i4a6h	89	34	the	the	DT
cord-006788-kz8i4a6h	89	35	postprandial	postprandial	JJ
cord-006788-kz8i4a6h	89	36	serum	serum	NN
cord-006788-kz8i4a6h	89	37	and	and	CC
cord-006788-kz8i4a6h	89	38	transintestinal	transintestinal	JJ
cord-006788-kz8i4a6h	89	39	flux	flux	NN
cord-006788-kz8i4a6h	89	40	of	of	IN
cord-006788-kz8i4a6h	89	41	bile	bile	NN
cord-006788-kz8i4a6h	89	42	acids	acid	NNS
cord-006788-kz8i4a6h	89	43	[	[	-LRB-
cord-006788-kz8i4a6h	89	44	2	2	CD
cord-006788-kz8i4a6h	89	45	,	,	,
cord-006788-kz8i4a6h	89	46	49	49	CD
cord-006788-kz8i4a6h	89	47	]	]	-RRB-
cord-006788-kz8i4a6h	89	48	(	(	-LRB-
cord-006788-kz8i4a6h	89	49	Fig	Fig	NNP
cord-006788-kz8i4a6h	89	50	.	.	NNP
cord-006788-kz8i4a6h	89	51	2	2	CD
cord-006788-kz8i4a6h	89	52	)	)	-RRB-
cord-006788-kz8i4a6h	89	53	.	.	.
cord-006788-kz8i4a6h	90	1	This	this	DT
cord-006788-kz8i4a6h	90	2	axis	axis	NN
cord-006788-kz8i4a6h	90	3	serves	serve	VBZ
cord-006788-kz8i4a6h	90	4	to	to	TO
cord-006788-kz8i4a6h	90	5	control	control	VB
cord-006788-kz8i4a6h	90	6	the	the	DT
cord-006788-kz8i4a6h	90	7	enterohepatic	enterohepatic	JJ
cord-006788-kz8i4a6h	90	8	and	and	CC
cord-006788-kz8i4a6h	90	9	systemic	systemic	JJ
cord-006788-kz8i4a6h	90	10	levels	level	NNS
cord-006788-kz8i4a6h	90	11	of	of	IN
cord-006788-kz8i4a6h	90	12	bile	bile	NN
cord-006788-kz8i4a6h	90	13	acids	acid	NNS
cord-006788-kz8i4a6h	90	14	negatively	negatively	RB
cord-006788-kz8i4a6h	90	15	,	,	,
cord-006788-kz8i4a6h	90	16	which	which	WDT
cord-006788-kz8i4a6h	90	17	facilitate	facilitate	VBP
cord-006788-kz8i4a6h	90	18	the	the	DT
cord-006788-kz8i4a6h	90	19	uptake	uptake	NN
cord-006788-kz8i4a6h	90	20	and	and	CC
cord-006788-kz8i4a6h	90	21	absorption	absorption	NN
cord-006788-kz8i4a6h	90	22	of	of	IN
cord-006788-kz8i4a6h	90	23	dietary	dietary	JJ
cord-006788-kz8i4a6h	90	24	lipids	lipid	NNS
cord-006788-kz8i4a6h	90	25	after	after	IN
cord-006788-kz8i4a6h	90	26	a	a	DT
cord-006788-kz8i4a6h	90	27	meal	meal	NN
cord-006788-kz8i4a6h	90	28	but	but	CC
cord-006788-kz8i4a6h	90	29	are	be	VBP
cord-006788-kz8i4a6h	90	30	toxic	toxic	JJ
cord-006788-kz8i4a6h	90	31	as	as	IN
cord-006788-kz8i4a6h	90	32	biodetergent	biodetergent	NN
cord-006788-kz8i4a6h	90	33	if	if	IN
cord-006788-kz8i4a6h	90	34	the	the	DT
cord-006788-kz8i4a6h	90	35	flux	flux	NN
cord-006788-kz8i4a6h	90	36	is	be	VBZ
cord-006788-kz8i4a6h	90	37	prolonged	prolong	VBN
cord-006788-kz8i4a6h	90	38	at	at	IN
cord-006788-kz8i4a6h	90	39	increased	increase	VBN
cord-006788-kz8i4a6h	90	40	levels	level	NNS
cord-006788-kz8i4a6h	90	41	.	.	.
cord-006788-kz8i4a6h	91	1	The	the	DT
cord-006788-kz8i4a6h	91	2	ileal	ileal	JJ
cord-006788-kz8i4a6h	91	3	initiation	initiation	NN
cord-006788-kz8i4a6h	91	4	of	of	IN
cord-006788-kz8i4a6h	91	5	the	the	DT
cord-006788-kz8i4a6h	91	6	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	91	7	signal	signal	NN
cord-006788-kz8i4a6h	91	8	is	be	VBZ
cord-006788-kz8i4a6h	91	9	under	under	IN
cord-006788-kz8i4a6h	91	10	the	the	DT
cord-006788-kz8i4a6h	91	11	transcriptional	transcriptional	JJ
cord-006788-kz8i4a6h	91	12	control	control	NN
cord-006788-kz8i4a6h	91	13	of	of	IN
cord-006788-kz8i4a6h	91	14	FXR	FXR	NNP
cord-006788-kz8i4a6h	91	15	,	,	,
cord-006788-kz8i4a6h	91	16	which	which	WDT
cord-006788-kz8i4a6h	91	17	is	be	VBZ
cord-006788-kz8i4a6h	91	18	stimulated	stimulate	VBN
cord-006788-kz8i4a6h	91	19	by	by	IN
cord-006788-kz8i4a6h	91	20	the	the	DT
cord-006788-kz8i4a6h	91	21	reabsorbed	reabsorb	VBN
cord-006788-kz8i4a6h	91	22	enterocyte	enterocyte	HYPH
cord-006788-kz8i4a6h	91	23	bile	bile	NN
cord-006788-kz8i4a6h	91	24	acids	acid	NNS
cord-006788-kz8i4a6h	91	25	as	as	IN
cord-006788-kz8i4a6h	91	26	a	a	DT
cord-006788-kz8i4a6h	91	27	natural	natural	JJ
cord-006788-kz8i4a6h	91	28	ligand	ligand	NN
cord-006788-kz8i4a6h	91	29	that	that	WDT
cord-006788-kz8i4a6h	91	30	is	be	VBZ
cord-006788-kz8i4a6h	91	31	originally	originally	RB
cord-006788-kz8i4a6h	91	32	released	release	VBN
cord-006788-kz8i4a6h	91	33	from	from	IN
cord-006788-kz8i4a6h	91	34	gallbladder	gallbladder	NN
cord-006788-kz8i4a6h	91	35	and	and	CC
cord-006788-kz8i4a6h	91	36	mixed	mix	VBN
cord-006788-kz8i4a6h	91	37	with	with	IN
cord-006788-kz8i4a6h	91	38	food	food	NN
cord-006788-kz8i4a6h	91	39	traveling	travel	VBG
cord-006788-kz8i4a6h	91	40	down	down	RP
cord-006788-kz8i4a6h	91	41	from	from	IN
cord-006788-kz8i4a6h	91	42	the	the	DT
cord-006788-kz8i4a6h	91	43	duodenum	duodenum	NN
cord-006788-kz8i4a6h	91	44	to	to	IN
cord-006788-kz8i4a6h	91	45	jejunum	jejunum	NN
cord-006788-kz8i4a6h	91	46	and	and	CC
cord-006788-kz8i4a6h	91	47	ileum	ileum	NN
cord-006788-kz8i4a6h	91	48	.	.	.
cord-006788-kz8i4a6h	92	1	This	this	DT
cord-006788-kz8i4a6h	92	2	enterocytederived	enterocytederived	JJ
cord-006788-kz8i4a6h	92	3	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	92	4	activates	activate	VBZ
cord-006788-kz8i4a6h	92	5	the	the	DT
cord-006788-kz8i4a6h	92	6	remote	remote	JJ
cord-006788-kz8i4a6h	92	7	FGFR4-KLB	FGFR4-KLB	NNP
cord-006788-kz8i4a6h	92	8	complex	complex	JJ
cord-006788-kz8i4a6h	92	9	[	[	-LRB-
cord-006788-kz8i4a6h	92	10	67	67	CD
cord-006788-kz8i4a6h	92	11	]	]	-RRB-
cord-006788-kz8i4a6h	92	12	residing	reside	VBG
cord-006788-kz8i4a6h	92	13	across	across	IN
cord-006788-kz8i4a6h	92	14	the	the	DT
cord-006788-kz8i4a6h	92	15	membrane	membrane	NN
cord-006788-kz8i4a6h	92	16	of	of	IN
cord-006788-kz8i4a6h	92	17	hepatocytes	hepatocyte	NNS
cord-006788-kz8i4a6h	92	18	in	in	IN
cord-006788-kz8i4a6h	92	19	the	the	DT
cord-006788-kz8i4a6h	92	20	liver	liver	NN
cord-006788-kz8i4a6h	92	21	,	,	,
cord-006788-kz8i4a6h	92	22	resulting	result	VBG
cord-006788-kz8i4a6h	92	23	in	in	IN
cord-006788-kz8i4a6h	92	24	a	a	DT
cord-006788-kz8i4a6h	92	25	major	major	JJ
cord-006788-kz8i4a6h	92	26	feedback	feedback	NN
cord-006788-kz8i4a6h	92	27	termination	termination	NN
cord-006788-kz8i4a6h	92	28	of	of	IN
cord-006788-kz8i4a6h	92	29	the	the	DT
cord-006788-kz8i4a6h	92	30	transcription	transcription	NN
cord-006788-kz8i4a6h	92	31	of	of	IN
cord-006788-kz8i4a6h	92	32	the	the	DT
cord-006788-kz8i4a6h	92	33	rate	rate	NN
cord-006788-kz8i4a6h	92	34	-	-	HYPH
cord-006788-kz8i4a6h	92	35	limiting	limit	VBG
cord-006788-kz8i4a6h	92	36	enzymes	enzyme	NNS
cord-006788-kz8i4a6h	92	37	Cyp7A1	Cyp7A1	VBN
cord-006788-kz8i4a6h	93	1	and	and	CC
cord-006788-kz8i4a6h	93	2	Cyp8b1	cyp8b1	CC
cord-006788-kz8i4a6h	93	3	in	in	IN
cord-006788-kz8i4a6h	93	4	the	the	DT
cord-006788-kz8i4a6h	93	5	bile	bile	NN
cord-006788-kz8i4a6h	93	6	acid	acid	NN
cord-006788-kz8i4a6h	93	7	biosynthesis	biosynthesis	NN
cord-006788-kz8i4a6h	93	8	pathways	pathway	NNS
cord-006788-kz8i4a6h	93	9	[	[	-LRB-
cord-006788-kz8i4a6h	93	10	49	49	CD
cord-006788-kz8i4a6h	93	11	,	,	,
cord-006788-kz8i4a6h	93	12	76	76	CD
cord-006788-kz8i4a6h	93	13	]	]	-RRB-
cord-006788-kz8i4a6h	93	14	.	.	.
cord-006788-kz8i4a6h	94	1	Therefore	therefore	RB
cord-006788-kz8i4a6h	94	2	,	,	,
cord-006788-kz8i4a6h	94	3	the	the	DT
cord-006788-kz8i4a6h	94	4	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	94	5	axis	axis	NN
cord-006788-kz8i4a6h	94	6	triggers	trigger	VBZ
cord-006788-kz8i4a6h	94	7	the	the	DT
cord-006788-kz8i4a6h	94	8	shut	shut	NN
cord-006788-kz8i4a6h	94	9	-	-	HYPH
cord-006788-kz8i4a6h	94	10	off	off	NN
cord-006788-kz8i4a6h	94	11	of	of	IN
cord-006788-kz8i4a6h	94	12	hepatic	hepatic	JJ
cord-006788-kz8i4a6h	94	13	biosynthesis	biosynthesis	NN
cord-006788-kz8i4a6h	94	14	of	of	IN
cord-006788-kz8i4a6h	94	15	new	new	JJ
cord-006788-kz8i4a6h	94	16	bile	bile	NN
cord-006788-kz8i4a6h	94	17	acids	acid	NNS
cord-006788-kz8i4a6h	94	18	from	from	IN
cord-006788-kz8i4a6h	94	19	cholesterol	cholesterol	NN
cord-006788-kz8i4a6h	94	20	and	and	CC
cord-006788-kz8i4a6h	94	21	the	the	DT
cord-006788-kz8i4a6h	94	22	refilling	refilling	NN
cord-006788-kz8i4a6h	94	23	of	of	IN
cord-006788-kz8i4a6h	94	24	gallbladder	gallbladder	NN
cord-006788-kz8i4a6h	94	25	approximately	approximately	RB
cord-006788-kz8i4a6h	94	26	2	2	CD
cord-006788-kz8i4a6h	94	27	h	h	NN
cord-006788-kz8i4a6h	94	28	after	after	IN
cord-006788-kz8i4a6h	94	29	the	the	DT
cord-006788-kz8i4a6h	94	30	peak	peak	NN
cord-006788-kz8i4a6h	94	31	of	of	IN
cord-006788-kz8i4a6h	94	32	serum	serum	NN
cord-006788-kz8i4a6h	94	33	bile	bile	NN
cord-006788-kz8i4a6h	94	34	acids	acid	NNS
cord-006788-kz8i4a6h	94	35	is	be	VBZ
cord-006788-kz8i4a6h	94	36	reached	reach	VBN
cord-006788-kz8i4a6h	94	37	.	.	.
cord-006788-kz8i4a6h	95	1	In	in	IN
cord-006788-kz8i4a6h	95	2	experimental	experimental	JJ
cord-006788-kz8i4a6h	95	3	animals	animal	NNS
cord-006788-kz8i4a6h	95	4	,	,	,
cord-006788-kz8i4a6h	95	5	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	95	6	overexpression	overexpression	NN
cord-006788-kz8i4a6h	95	7	or	or	CC
cord-006788-kz8i4a6h	95	8	administration	administration	NN
cord-006788-kz8i4a6h	95	9	elicits	elicit	VBZ
cord-006788-kz8i4a6h	95	10	other	other	JJ
cord-006788-kz8i4a6h	95	11	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	95	12	effects	effect	NNS
cord-006788-kz8i4a6h	95	13	[	[	-LRB-
cord-006788-kz8i4a6h	95	14	77	77	CD
cord-006788-kz8i4a6h	95	15	,	,	,
cord-006788-kz8i4a6h	95	16	78	78	CD
cord-006788-kz8i4a6h	95	17	]	]	-RRB-
cord-006788-kz8i4a6h	95	18	.	.	.
cord-006788-kz8i4a6h	96	1	Excessive	excessive	JJ
cord-006788-kz8i4a6h	96	2	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	96	3	promotes	promote	VBZ
cord-006788-kz8i4a6h	96	4	lipolysis	lipolysis	NN
cord-006788-kz8i4a6h	96	5	,	,	,
cord-006788-kz8i4a6h	96	6	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	96	7	rate	rate	NN
cord-006788-kz8i4a6h	96	8	,	,	,
cord-006788-kz8i4a6h	96	9	and	and	CC
cord-006788-kz8i4a6h	96	10	energy	energy	NN
cord-006788-kz8i4a6h	96	11	expenditure	expenditure	NN
cord-006788-kz8i4a6h	96	12	and	and	CC
cord-006788-kz8i4a6h	96	13	reduces	reduce	VBZ
cord-006788-kz8i4a6h	96	14	body	body	NN
cord-006788-kz8i4a6h	96	15	weight	weight	NN
cord-006788-kz8i4a6h	96	16	,	,	,
cord-006788-kz8i4a6h	96	17	serum	serum	NN
cord-006788-kz8i4a6h	96	18	glucose	glucose	NN
cord-006788-kz8i4a6h	96	19	,	,	,
cord-006788-kz8i4a6h	96	20	and	and	CC
cord-006788-kz8i4a6h	96	21	lipids	lipid	NNS
cord-006788-kz8i4a6h	96	22	.	.	.
cord-006788-kz8i4a6h	97	1	The	the	DT
cord-006788-kz8i4a6h	97	2	FGFR1-KLB	FGFR1-KLB	NNP
cord-006788-kz8i4a6h	97	3	complex	complex	NN
cord-006788-kz8i4a6h	97	4	on	on	IN
cord-006788-kz8i4a6h	97	5	adipose	adipose	JJ
cord-006788-kz8i4a6h	97	6	tissues	tissue	NNS
cord-006788-kz8i4a6h	97	7	,	,	,
cord-006788-kz8i4a6h	97	8	including	include	VBG
cord-006788-kz8i4a6h	97	9	WAT	WAT	NNP
cord-006788-kz8i4a6h	97	10	and	and	CC
cord-006788-kz8i4a6h	97	11	BAT	BAT	NNP
cord-006788-kz8i4a6h	97	12	,	,	,
cord-006788-kz8i4a6h	97	13	was	be	VBD
cord-006788-kz8i4a6h	97	14	suggested	suggest	VBN
cord-006788-kz8i4a6h	97	15	in	in	IN
cord-006788-kz8i4a6h	97	16	a	a	DT
cord-006788-kz8i4a6h	97	17	large	large	JJ
cord-006788-kz8i4a6h	97	18	part	part	NN
cord-006788-kz8i4a6h	97	19	to	to	TO
cord-006788-kz8i4a6h	97	20	mediate	mediate	VB
cord-006788-kz8i4a6h	97	21	these	these	DT
cord-006788-kz8i4a6h	97	22	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	97	23	effects	effect	NNS
cord-006788-kz8i4a6h	97	24	[	[	-LRB-
cord-006788-kz8i4a6h	97	25	79	79	CD
cord-006788-kz8i4a6h	97	26	]	]	-RRB-
cord-006788-kz8i4a6h	98	1	(	(	-LRB-
cord-006788-kz8i4a6h	98	2	Fig	Fig	NNP
cord-006788-kz8i4a6h	98	3	.	.	NNP
cord-006788-kz8i4a6h	98	4	2	2	CD
cord-006788-kz8i4a6h	98	5	)	)	-RRB-
cord-006788-kz8i4a6h	98	6	.	.	.
cord-006788-kz8i4a6h	99	1	However	however	RB
cord-006788-kz8i4a6h	99	2	,	,	,
cord-006788-kz8i4a6h	99	3	the	the	DT
cord-006788-kz8i4a6h	99	4	direct	direct	JJ
cord-006788-kz8i4a6h	99	5	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	99	6	roles	role	NNS
cord-006788-kz8i4a6h	99	7	of	of	IN
cord-006788-kz8i4a6h	99	8	bile	bile	NN
cord-006788-kz8i4a6h	99	9	acid	acid	NN
cord-006788-kz8i4a6h	99	10	fluctuation	fluctuation	NN
cord-006788-kz8i4a6h	99	11	and	and	CC
cord-006788-kz8i4a6h	99	12	bile	bile	NN
cord-006788-kz8i4a6h	99	13	acid	acid	NN
cord-006788-kz8i4a6h	99	14	-	-	HYPH
cord-006788-kz8i4a6h	99	15	activated	activate	VBN
cord-006788-kz8i4a6h	99	16	FXR	FXR	NNP
cord-006788-kz8i4a6h	99	17	and	and	CC
cord-006788-kz8i4a6h	99	18	TGR5	TGR5	NNP
cord-006788-kz8i4a6h	99	19	can	can	MD
cord-006788-kz8i4a6h	99	20	not	not	RB
cord-006788-kz8i4a6h	99	21	be	be	VB
cord-006788-kz8i4a6h	99	22	excluded	exclude	VBN
cord-006788-kz8i4a6h	99	23	.	.	.
cord-006788-kz8i4a6h	100	1	Although	although	IN
cord-006788-kz8i4a6h	100	2	there	there	EX
cord-006788-kz8i4a6h	100	3	is	be	VBZ
cord-006788-kz8i4a6h	100	4	no	no	DT
cord-006788-kz8i4a6h	100	5	evidence	evidence	NN
cord-006788-kz8i4a6h	100	6	for	for	IN
cord-006788-kz8i4a6h	100	7	any	any	DT
cord-006788-kz8i4a6h	100	8	genetic	genetic	JJ
cord-006788-kz8i4a6h	100	9	mutation	mutation	NN
cord-006788-kz8i4a6h	100	10	of	of	IN
cord-006788-kz8i4a6h	100	11	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	100	12	gene	gene	NN
cord-006788-kz8i4a6h	100	13	that	that	WDT
cord-006788-kz8i4a6h	100	14	may	may	MD
cord-006788-kz8i4a6h	100	15	be	be	VB
cord-006788-kz8i4a6h	100	16	involved	involve	VBN
cord-006788-kz8i4a6h	100	17	in	in	IN
cord-006788-kz8i4a6h	100	18	human	human	JJ
cord-006788-kz8i4a6h	100	19	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	100	20	diseases	disease	NNS
cord-006788-kz8i4a6h	100	21	,	,	,
cord-006788-kz8i4a6h	100	22	its	-PRON-	PRP$
cord-006788-kz8i4a6h	100	23	reduced	reduced	JJ
cord-006788-kz8i4a6h	100	24	synthesis	synthesis	NN
cord-006788-kz8i4a6h	100	25	and	and	CC
cord-006788-kz8i4a6h	100	26	blood	blood	NN
cord-006788-kz8i4a6h	100	27	levels	level	NNS
cord-006788-kz8i4a6h	100	28	are	be	VBP
cord-006788-kz8i4a6h	100	29	suggestive	suggestive	JJ
cord-006788-kz8i4a6h	100	30	of	of	IN
cord-006788-kz8i4a6h	100	31	a	a	DT
cord-006788-kz8i4a6h	100	32	causative	causative	JJ
cord-006788-kz8i4a6h	100	33	factor	factor	NN
cord-006788-kz8i4a6h	100	34	of	of	IN
cord-006788-kz8i4a6h	100	35	chronic	chronic	JJ
cord-006788-kz8i4a6h	100	36	bile	bile	NN
cord-006788-kz8i4a6h	100	37	acid	acid	NN
cord-006788-kz8i4a6h	100	38	diarrhea	diarrhea	NN
cord-006788-kz8i4a6h	100	39	[	[	-LRB-
cord-006788-kz8i4a6h	100	40	80	80	CD
cord-006788-kz8i4a6h	100	41	,	,	,
cord-006788-kz8i4a6h	100	42	81	81	CD
cord-006788-kz8i4a6h	100	43	]	]	-RRB-
cord-006788-kz8i4a6h	100	44	and	and	CC
cord-006788-kz8i4a6h	100	45	certain	certain	JJ
cord-006788-kz8i4a6h	100	46	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	100	47	disorders	disorder	NNS
cord-006788-kz8i4a6h	100	48	,	,	,
cord-006788-kz8i4a6h	100	49	such	such	JJ
cord-006788-kz8i4a6h	100	50	as	as	IN
cord-006788-kz8i4a6h	100	51	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	100	52	syndrome	syndrome	NN
cord-006788-kz8i4a6h	100	53	,	,	,
cord-006788-kz8i4a6h	100	54	nonalcoholic	nonalcoholic	JJ
cord-006788-kz8i4a6h	100	55	fatty	fatty	JJ
cord-006788-kz8i4a6h	100	56	liver	liver	NN
cord-006788-kz8i4a6h	100	57	disease	disease	NN
cord-006788-kz8i4a6h	100	58	(	(	-LRB-
cord-006788-kz8i4a6h	100	59	NAFLD	NAFLD	NNP
cord-006788-kz8i4a6h	100	60	)	)	-RRB-
cord-006788-kz8i4a6h	100	61	,	,	,
cord-006788-kz8i4a6h	100	62	and	and	CC
cord-006788-kz8i4a6h	100	63	insulin	insulin	NN
cord-006788-kz8i4a6h	100	64	resistance	resistance	NN
cord-006788-kz8i4a6h	100	65	.	.	.
cord-006788-kz8i4a6h	101	1	Experimentally	experimentally	RB
cord-006788-kz8i4a6h	101	2	,	,	,
cord-006788-kz8i4a6h	101	3	the	the	DT
cord-006788-kz8i4a6h	101	4	Fig	Fig	NNP
cord-006788-kz8i4a6h	101	5	.	.	NNP
cord-006788-kz8i4a6h	101	6	2	2	CD
cord-006788-kz8i4a6h	101	7	FGF19	fgf19	NN
cord-006788-kz8i4a6h	101	8	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	101	9	axis	axis	NN
cord-006788-kz8i4a6h	101	10	.	.	.
cord-006788-kz8i4a6h	102	1	The	the	DT
cord-006788-kz8i4a6h	102	2	major	major	JJ
cord-006788-kz8i4a6h	102	3	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	102	4	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	102	5	axis	axis	NN
cord-006788-kz8i4a6h	102	6	drives	drive	VBZ
cord-006788-kz8i4a6h	102	7	a	a	DT
cord-006788-kz8i4a6h	102	8	temporal	temporal	JJ
cord-006788-kz8i4a6h	102	9	interorgan	interorgan	NN
cord-006788-kz8i4a6h	102	10	crosstalk	crosstalk	NN
cord-006788-kz8i4a6h	102	11	from	from	IN
cord-006788-kz8i4a6h	102	12	the	the	DT
cord-006788-kz8i4a6h	102	13	ileum	ileum	NN
cord-006788-kz8i4a6h	102	14	to	to	IN
cord-006788-kz8i4a6h	102	15	the	the	DT
cord-006788-kz8i4a6h	102	16	liver	liver	NN
cord-006788-kz8i4a6h	102	17	in	in	IN
cord-006788-kz8i4a6h	102	18	response	response	NN
cord-006788-kz8i4a6h	102	19	to	to	IN
cord-006788-kz8i4a6h	102	20	the	the	DT
cord-006788-kz8i4a6h	102	21	increase	increase	NN
cord-006788-kz8i4a6h	102	22	in	in	IN
cord-006788-kz8i4a6h	102	23	postprandial	postprandial	JJ
cord-006788-kz8i4a6h	102	24	serum	serum	NN
cord-006788-kz8i4a6h	102	25	and	and	CC
cord-006788-kz8i4a6h	102	26	transintestinal	transintestinal	NN
cord-006788-kz8i4a6h	102	27	flux	flux	NN
cord-006788-kz8i4a6h	102	28	of	of	IN
cord-006788-kz8i4a6h	102	29	bile	bile	NN
cord-006788-kz8i4a6h	102	30	acids	acid	NNS
cord-006788-kz8i4a6h	102	31	to	to	TO
cord-006788-kz8i4a6h	102	32	discontinue	discontinue	VB
cord-006788-kz8i4a6h	102	33	the	the	DT
cord-006788-kz8i4a6h	102	34	biosynthesis	biosynthesis	NN
cord-006788-kz8i4a6h	102	35	of	of	IN
cord-006788-kz8i4a6h	102	36	new	new	JJ
cord-006788-kz8i4a6h	102	37	bile	bile	NN
cord-006788-kz8i4a6h	102	38	acids	acid	NNS
cord-006788-kz8i4a6h	102	39	after	after	IN
cord-006788-kz8i4a6h	102	40	sufficient	sufficient	JJ
cord-006788-kz8i4a6h	102	41	food	food	NN
cord-006788-kz8i4a6h	102	42	digestion	digestion	NN
cord-006788-kz8i4a6h	102	43	,	,	,
cord-006788-kz8i4a6h	102	44	thereby	thereby	RB
cord-006788-kz8i4a6h	102	45	preventing	prevent	VBG
cord-006788-kz8i4a6h	102	46	the	the	DT
cord-006788-kz8i4a6h	102	47	prolonged	prolong	VBN
cord-006788-kz8i4a6h	102	48	exposure	exposure	NN
cord-006788-kz8i4a6h	102	49	of	of	IN
cord-006788-kz8i4a6h	102	50	tissues	tissue	NNS
cord-006788-kz8i4a6h	102	51	to	to	IN
cord-006788-kz8i4a6h	102	52	potential	potential	JJ
cord-006788-kz8i4a6h	102	53	bile	bile	NN
cord-006788-kz8i4a6h	102	54	acid	acid	NN
cord-006788-kz8i4a6h	102	55	toxicity	toxicity	NN
cord-006788-kz8i4a6h	102	56	.	.	.
cord-006788-kz8i4a6h	103	1	Pharmacological	pharmacological	JJ
cord-006788-kz8i4a6h	103	2	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	103	3	may	may	MD
cord-006788-kz8i4a6h	103	4	also	also	RB
cord-006788-kz8i4a6h	103	5	initiate	initiate	VB
cord-006788-kz8i4a6h	103	6	multiple	multiple	JJ
cord-006788-kz8i4a6h	103	7	signal	signal	NN
cord-006788-kz8i4a6h	103	8	axes	axis	NNS
cord-006788-kz8i4a6h	103	9	to	to	TO
cord-006788-kz8i4a6h	103	10	drive	drive	VB
cord-006788-kz8i4a6h	103	11	effects	effect	NNS
cord-006788-kz8i4a6h	103	12	on	on	IN
cord-006788-kz8i4a6h	103	13	multiple	multiple	JJ
cord-006788-kz8i4a6h	103	14	tissues	tissue	NNS
cord-006788-kz8i4a6h	103	15	/	/	SYM
cord-006788-kz8i4a6h	103	16	organs	organ	NNS
cord-006788-kz8i4a6h	103	17	,	,	,
cord-006788-kz8i4a6h	103	18	such	such	JJ
cord-006788-kz8i4a6h	103	19	as	as	IN
cord-006788-kz8i4a6h	103	20	promoting	promote	VBG
cord-006788-kz8i4a6h	103	21	(	(	-LRB-
cord-006788-kz8i4a6h	103	22	green	green	JJ
cord-006788-kz8i4a6h	103	23	arrow	arrow	NN
cord-006788-kz8i4a6h	103	24	)	)	-RRB-
cord-006788-kz8i4a6h	103	25	energy	energy	NN
cord-006788-kz8i4a6h	103	26	expenditure	expenditure	NN
cord-006788-kz8i4a6h	103	27	in	in	IN
cord-006788-kz8i4a6h	103	28	white	white	JJ
cord-006788-kz8i4a6h	103	29	and	and	CC
cord-006788-kz8i4a6h	103	30	brown	brown	JJ
cord-006788-kz8i4a6h	103	31	adipose	adipose	JJ
cord-006788-kz8i4a6h	103	32	tissues	tissue	NNS
cord-006788-kz8i4a6h	103	33	,	,	,
cord-006788-kz8i4a6h	103	34	increasing	increase	VBG
cord-006788-kz8i4a6h	103	35	muscle	muscle	NN
cord-006788-kz8i4a6h	103	36	mass	mass	NN
cord-006788-kz8i4a6h	103	37	and	and	CC
cord-006788-kz8i4a6h	103	38	insulin	insulin	NN
cord-006788-kz8i4a6h	103	39	sensitivity	sensitivity	NN
cord-006788-kz8i4a6h	103	40	,	,	,
cord-006788-kz8i4a6h	103	41	and	and	CC
cord-006788-kz8i4a6h	103	42	preventing	prevent	VBG
cord-006788-kz8i4a6h	103	43	(	(	-LRB-
cord-006788-kz8i4a6h	103	44	red	red	JJ
cord-006788-kz8i4a6h	103	45	long	long	JJ
cord-006788-kz8i4a6h	103	46	-	-	HYPH
cord-006788-kz8i4a6h	103	47	tailed	tailed	JJ
cord-006788-kz8i4a6h	103	48	"	"	``
cord-006788-kz8i4a6h	103	49	T	t	NN
cord-006788-kz8i4a6h	103	50	"	"	''
cord-006788-kz8i4a6h	103	51	sign	sign	NN
cord-006788-kz8i4a6h	103	52	)	)	-RRB-
cord-006788-kz8i4a6h	103	53	systemic	systemic	JJ
cord-006788-kz8i4a6h	103	54	hyperglycemia	hyperglycemia	NN
cord-006788-kz8i4a6h	103	55	and	and	CC
cord-006788-kz8i4a6h	103	56	hyperlipidemia	hyperlipidemia	NN
cord-006788-kz8i4a6h	103	57	.	.	.
cord-006788-kz8i4a6h	104	1	FAA	FAA	NNP
cord-006788-kz8i4a6h	104	2	:	:	:
cord-006788-kz8i4a6h	104	3	free	free	JJ
cord-006788-kz8i4a6h	104	4	fatty	fatty	JJ
cord-006788-kz8i4a6h	104	5	acids	acid	NNS
cord-006788-kz8i4a6h	104	6	.	.	.
cord-006788-kz8i4a6h	105	1	neutralization	neutralization	NN
cord-006788-kz8i4a6h	105	2	of	of	IN
cord-006788-kz8i4a6h	105	3	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	105	4	by	by	IN
cord-006788-kz8i4a6h	105	5	specific	specific	JJ
cord-006788-kz8i4a6h	105	6	anti	anti	JJ
cord-006788-kz8i4a6h	105	7	-	-	JJ
cord-006788-kz8i4a6h	105	8	FGF19	fgf19	JJ
cord-006788-kz8i4a6h	105	9	antibodies	antibody	NNS
cord-006788-kz8i4a6h	105	10	causes	cause	VBZ
cord-006788-kz8i4a6h	105	11	severe	severe	JJ
cord-006788-kz8i4a6h	105	12	diarrhea	diarrhea	NN
cord-006788-kz8i4a6h	105	13	in	in	IN
cord-006788-kz8i4a6h	105	14	monkeys	monkey	NNS
cord-006788-kz8i4a6h	105	15	accompanied	accompany	VBN
cord-006788-kz8i4a6h	105	16	by	by	IN
cord-006788-kz8i4a6h	105	17	the	the	DT
cord-006788-kz8i4a6h	105	18	increases	increase	NNS
cord-006788-kz8i4a6h	105	19	in	in	IN
cord-006788-kz8i4a6h	105	20	bile	bile	NN
cord-006788-kz8i4a6h	105	21	acid	acid	NN
cord-006788-kz8i4a6h	105	22	synthesis	synthesis	NN
cord-006788-kz8i4a6h	105	23	,	,	,
cord-006788-kz8i4a6h	105	24	serum	serum	NN
cord-006788-kz8i4a6h	105	25	and	and	CC
cord-006788-kz8i4a6h	105	26	fecal	fecal	JJ
cord-006788-kz8i4a6h	105	27	total	total	JJ
cord-006788-kz8i4a6h	105	28	bile	bile	NN
cord-006788-kz8i4a6h	105	29	acids	acid	NNS
cord-006788-kz8i4a6h	105	30	,	,	,
cord-006788-kz8i4a6h	105	31	specific	specific	JJ
cord-006788-kz8i4a6h	105	32	bile	bile	NN
cord-006788-kz8i4a6h	105	33	acid	acid	NN
cord-006788-kz8i4a6h	105	34	transporters	transporter	NNS
cord-006788-kz8i4a6h	105	35	,	,	,
cord-006788-kz8i4a6h	105	36	and	and	CC
cord-006788-kz8i4a6h	105	37	liver	liver	NN
cord-006788-kz8i4a6h	105	38	toxicity	toxicity	NN
cord-006788-kz8i4a6h	105	39	[	[	-LRB-
cord-006788-kz8i4a6h	105	40	82	82	CD
cord-006788-kz8i4a6h	105	41	]	]	-RRB-
cord-006788-kz8i4a6h	105	42	.	.	.
cord-006788-kz8i4a6h	106	1	In	in	IN
cord-006788-kz8i4a6h	106	2	obese	obese	JJ
cord-006788-kz8i4a6h	106	3	patients	patient	NNS
cord-006788-kz8i4a6h	106	4	who	who	WP
cord-006788-kz8i4a6h	106	5	undergo	undergo	VBP
cord-006788-kz8i4a6h	106	6	Roux	roux	NN
cord-006788-kz8i4a6h	106	7	-	-	HYPH
cord-006788-kz8i4a6h	106	8	en	en	FW
cord-006788-kz8i4a6h	106	9	-	-	HYPH
cord-006788-kz8i4a6h	106	10	Y	Y	NNP
cord-006788-kz8i4a6h	106	11	gastric	gastric	JJ
cord-006788-kz8i4a6h	106	12	bypass	bypass	NN
cord-006788-kz8i4a6h	106	13	bariatric	bariatric	NN
cord-006788-kz8i4a6h	106	14	surgery	surgery	NN
cord-006788-kz8i4a6h	106	15	,	,	,
cord-006788-kz8i4a6h	106	16	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	106	17	increases	increase	NNS
cord-006788-kz8i4a6h	106	18	to	to	IN
cord-006788-kz8i4a6h	106	19	normal	normal	JJ
cord-006788-kz8i4a6h	106	20	values	value	NNS
cord-006788-kz8i4a6h	106	21	,	,	,
cord-006788-kz8i4a6h	106	22	which	which	WDT
cord-006788-kz8i4a6h	106	23	at	at	IN
cord-006788-kz8i4a6h	106	24	least	least	JJS
cord-006788-kz8i4a6h	106	25	partially	partially	RB
cord-006788-kz8i4a6h	106	26	underlie	underlie	VB
cord-006788-kz8i4a6h	106	27	the	the	DT
cord-006788-kz8i4a6h	106	28	benefits	benefit	NNS
cord-006788-kz8i4a6h	106	29	of	of	IN
cord-006788-kz8i4a6h	106	30	this	this	DT
cord-006788-kz8i4a6h	106	31	approach	approach	NN
cord-006788-kz8i4a6h	106	32	[	[	-LRB-
cord-006788-kz8i4a6h	106	33	83	83	CD
cord-006788-kz8i4a6h	106	34	]	]	-RRB-
cord-006788-kz8i4a6h	106	35	.	.	.
cord-006788-kz8i4a6h	107	1	On	on	IN
cord-006788-kz8i4a6h	107	2	the	the	DT
cord-006788-kz8i4a6h	107	3	other	other	JJ
cord-006788-kz8i4a6h	107	4	hand	hand	NN
cord-006788-kz8i4a6h	107	5	,	,	,
cord-006788-kz8i4a6h	107	6	high	high	JJ
cord-006788-kz8i4a6h	107	7	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	107	8	expression	expression	NN
cord-006788-kz8i4a6h	107	9	levels	level	NNS
cord-006788-kz8i4a6h	107	10	are	be	VBP
cord-006788-kz8i4a6h	107	11	found	find	VBN
cord-006788-kz8i4a6h	107	12	in	in	IN
cord-006788-kz8i4a6h	107	13	the	the	DT
cord-006788-kz8i4a6h	107	14	livers	liver	NNS
cord-006788-kz8i4a6h	107	15	of	of	IN
cord-006788-kz8i4a6h	107	16	patients	patient	NNS
cord-006788-kz8i4a6h	107	17	with	with	IN
cord-006788-kz8i4a6h	107	18	extrahepatic	extrahepatic	JJ
cord-006788-kz8i4a6h	107	19	cholestasis	cholestasis	NN
cord-006788-kz8i4a6h	107	20	[	[	-LRB-
cord-006788-kz8i4a6h	107	21	84	84	CD
cord-006788-kz8i4a6h	107	22	,	,	,
cord-006788-kz8i4a6h	107	23	85	85	CD
cord-006788-kz8i4a6h	107	24	]	]	-RRB-
cord-006788-kz8i4a6h	107	25	,	,	,
cord-006788-kz8i4a6h	107	26	suggesting	suggest	VBG
cord-006788-kz8i4a6h	107	27	FGF19	FGF19	VBN
cord-006788-kz8i4a6h	107	28	as	as	IN
cord-006788-kz8i4a6h	107	29	a	a	DT
cord-006788-kz8i4a6h	107	30	therapeutic	therapeutic	JJ
cord-006788-kz8i4a6h	107	31	target	target	NN
cord-006788-kz8i4a6h	107	32	for	for	IN
cord-006788-kz8i4a6h	107	33	this	this	DT
cord-006788-kz8i4a6h	107	34	disease	disease	NN
cord-006788-kz8i4a6h	107	35	.	.	.
cord-006788-kz8i4a6h	108	1	Recently	recently	RB
cord-006788-kz8i4a6h	108	2	,	,	,
cord-006788-kz8i4a6h	108	3	the	the	DT
cord-006788-kz8i4a6h	108	4	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	108	5	axis	axis	NN
cord-006788-kz8i4a6h	108	6	was	be	VBD
cord-006788-kz8i4a6h	108	7	shown	show	VBN
cord-006788-kz8i4a6h	108	8	to	to	TO
cord-006788-kz8i4a6h	108	9	elicit	elicit	VB
cord-006788-kz8i4a6h	108	10	hypertrophic	hypertrophic	JJ
cord-006788-kz8i4a6h	108	11	and	and	CC
cord-006788-kz8i4a6h	108	12	protective	protective	JJ
cord-006788-kz8i4a6h	108	13	effects	effect	NNS
cord-006788-kz8i4a6h	108	14	on	on	IN
cord-006788-kz8i4a6h	108	15	the	the	DT
cord-006788-kz8i4a6h	108	16	skeletal	skeletal	JJ
cord-006788-kz8i4a6h	108	17	muscle	muscle	NN
cord-006788-kz8i4a6h	108	18	presumably	presumably	RB
cord-006788-kz8i4a6h	108	19	through	through	IN
cord-006788-kz8i4a6h	108	20	a	a	DT
cord-006788-kz8i4a6h	108	21	KLB	KLB	NNP
cord-006788-kz8i4a6h	108	22	-	-	HYPH
cord-006788-kz8i4a6h	108	23	FGFR4-dependent	FGFR4-dependent	NNP
cord-006788-kz8i4a6h	108	24	mechanism	mechanism	NN
cord-006788-kz8i4a6h	108	25	by	by	IN
cord-006788-kz8i4a6h	108	26	increasing	increase	VBG
cord-006788-kz8i4a6h	108	27	myofiber	myofiber	NN
cord-006788-kz8i4a6h	108	28	size	size	NN
cord-006788-kz8i4a6h	108	29	in	in	IN
cord-006788-kz8i4a6h	108	30	the	the	DT
cord-006788-kz8i4a6h	108	31	soleus	soleus	NN
cord-006788-kz8i4a6h	108	32	,	,	,
cord-006788-kz8i4a6h	108	33	muscle	muscle	NN
cord-006788-kz8i4a6h	108	34	mass	mass	NN
cord-006788-kz8i4a6h	108	35	,	,	,
cord-006788-kz8i4a6h	108	36	and	and	CC
cord-006788-kz8i4a6h	108	37	grip	grip	NN
cord-006788-kz8i4a6h	108	38	strength	strength	NN
cord-006788-kz8i4a6h	108	39	[	[	-LRB-
cord-006788-kz8i4a6h	108	40	86	86	CD
cord-006788-kz8i4a6h	108	41	]	]	-RRB-
cord-006788-kz8i4a6h	108	42	.	.	.
cord-006788-kz8i4a6h	109	1	Pharmacological	pharmacological	JJ
cord-006788-kz8i4a6h	109	2	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	109	3	ameliorates	ameliorate	VBZ
cord-006788-kz8i4a6h	109	4	skeletal	skeletal	JJ
cord-006788-kz8i4a6h	109	5	muscle	muscle	NN
cord-006788-kz8i4a6h	109	6	atrophy	atrophy	NN
cord-006788-kz8i4a6h	109	7	and	and	CC
cord-006788-kz8i4a6h	109	8	prevents	prevent	VBZ
cord-006788-kz8i4a6h	109	9	muscle	muscle	NN
cord-006788-kz8i4a6h	109	10	wasting	waste	VBG
cord-006788-kz8i4a6h	109	11	in	in	IN
cord-006788-kz8i4a6h	109	12	mice	mouse	NNS
cord-006788-kz8i4a6h	109	13	with	with	IN
cord-006788-kz8i4a6h	109	14	glucocorticoid	glucocorticoid	NN
cord-006788-kz8i4a6h	109	15	treatment	treatment	NN
cord-006788-kz8i4a6h	109	16	,	,	,
cord-006788-kz8i4a6h	109	17	obesity	obesity	NN
cord-006788-kz8i4a6h	109	18	,	,	,
cord-006788-kz8i4a6h	109	19	or	or	CC
cord-006788-kz8i4a6h	109	20	sarcopenia	sarcopenia	NN
cord-006788-kz8i4a6h	109	21	.	.	.
cord-006788-kz8i4a6h	110	1	These	these	DT
cord-006788-kz8i4a6h	110	2	results	result	NNS
cord-006788-kz8i4a6h	110	3	highlight	highlight	VBP
cord-006788-kz8i4a6h	110	4	a	a	DT
cord-006788-kz8i4a6h	110	5	potential	potential	JJ
cord-006788-kz8i4a6h	110	6	treatment	treatment	NN
cord-006788-kz8i4a6h	110	7	strategy	strategy	NN
cord-006788-kz8i4a6h	110	8	for	for	IN
cord-006788-kz8i4a6h	110	9	muscle	muscle	NN
cord-006788-kz8i4a6h	110	10	wasting	waste	VBG
cord-006788-kz8i4a6h	110	11	induced	induce	VBN
cord-006788-kz8i4a6h	110	12	by	by	IN
cord-006788-kz8i4a6h	110	13	glucocorticoid	glucocorticoid	NN
cord-006788-kz8i4a6h	110	14	treatment	treatment	NN
cord-006788-kz8i4a6h	110	15	,	,	,
cord-006788-kz8i4a6h	110	16	obesity	obesity	NN
cord-006788-kz8i4a6h	110	17	,	,	,
cord-006788-kz8i4a6h	110	18	aging	age	VBG
cord-006788-kz8i4a6h	110	19	,	,	,
cord-006788-kz8i4a6h	110	20	and	and	CC
cord-006788-kz8i4a6h	110	21	cachexia	cachexia	NN
cord-006788-kz8i4a6h	110	22	.	.	.
cord-006788-kz8i4a6h	111	1	However	however	RB
cord-006788-kz8i4a6h	111	2	,	,	,
cord-006788-kz8i4a6h	111	3	whether	whether	IN
cord-006788-kz8i4a6h	111	4	the	the	DT
cord-006788-kz8i4a6h	111	5	same	same	JJ
cord-006788-kz8i4a6h	111	6	treatment	treatment	NN
cord-006788-kz8i4a6h	111	7	will	will	MD
cord-006788-kz8i4a6h	111	8	have	have	VB
cord-006788-kz8i4a6h	111	9	a	a	DT
cord-006788-kz8i4a6h	111	10	similar	similar	JJ
cord-006788-kz8i4a6h	111	11	adverse	adverse	JJ
cord-006788-kz8i4a6h	111	12	effect	effect	NN
cord-006788-kz8i4a6h	111	13	on	on	IN
cord-006788-kz8i4a6h	111	14	the	the	DT
cord-006788-kz8i4a6h	111	15	liver	liver	NN
cord-006788-kz8i4a6h	111	16	still	still	RB
cord-006788-kz8i4a6h	111	17	has	have	VBZ
cord-006788-kz8i4a6h	111	18	to	to	TO
cord-006788-kz8i4a6h	111	19	be	be	VB
cord-006788-kz8i4a6h	111	20	determined	determine	VBN
cord-006788-kz8i4a6h	111	21	because	because	IN
cord-006788-kz8i4a6h	111	22	muscle	muscle	NN
cord-006788-kz8i4a6h	111	23	-	-	HYPH
cord-006788-kz8i4a6h	111	24	specific	specific	JJ
cord-006788-kz8i4a6h	111	25	transgenic	transgenic	JJ
cord-006788-kz8i4a6h	111	26	mice	mouse	NNS
cord-006788-kz8i4a6h	111	27	developed	develop	VBD
cord-006788-kz8i4a6h	111	28	prominent	prominent	JJ
cord-006788-kz8i4a6h	111	29	hepatocellular	hepatocellular	JJ
cord-006788-kz8i4a6h	111	30	carcinoma	carcinoma	NN
cord-006788-kz8i4a6h	111	31	(	(	-LRB-
cord-006788-kz8i4a6h	111	32	HCC	HCC	NNP
cord-006788-kz8i4a6h	111	33	)	)	-RRB-
cord-006788-kz8i4a6h	112	1	[	[	-LRB-
cord-006788-kz8i4a6h	112	2	87	87	CD
cord-006788-kz8i4a6h	112	3	]	]	-RRB-
cord-006788-kz8i4a6h	112	4	.	.	.
cord-006788-kz8i4a6h	113	1	Despite	despite	IN
cord-006788-kz8i4a6h	113	2	the	the	DT
cord-006788-kz8i4a6h	113	3	tumorigenic	tumorigenic	JJ
cord-006788-kz8i4a6h	113	4	concern	concern	NN
cord-006788-kz8i4a6h	113	5	,	,	,
cord-006788-kz8i4a6h	113	6	the	the	DT
cord-006788-kz8i4a6h	113	7	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	113	8	analog	analog	NN
cord-006788-kz8i4a6h	113	9	NGM282	NGM282	NNPS
cord-006788-kz8i4a6h	113	10	was	be	VBD
cord-006788-kz8i4a6h	113	11	tested	test	VBN
cord-006788-kz8i4a6h	113	12	in	in	IN
cord-006788-kz8i4a6h	113	13	patients	patient	NNS
cord-006788-kz8i4a6h	113	14	with	with	IN
cord-006788-kz8i4a6h	113	15	nonalcoholic	nonalcoholic	JJ
cord-006788-kz8i4a6h	113	16	steatohepatitis	steatohepatitis	NNP
cord-006788-kz8i4a6h	113	17	(	(	-LRB-
cord-006788-kz8i4a6h	113	18	NASH	NASH	NNP
cord-006788-kz8i4a6h	113	19	)	)	-RRB-
cord-006788-kz8i4a6h	113	20	.	.	.
cord-006788-kz8i4a6h	114	1	It	-PRON-	PRP
cord-006788-kz8i4a6h	114	2	markedly	markedly	RB
cord-006788-kz8i4a6h	114	3	reduced	reduce	VBD
cord-006788-kz8i4a6h	114	4	liver	liver	NN
cord-006788-kz8i4a6h	114	5	fat	fat	NN
cord-006788-kz8i4a6h	114	6	content	content	NN
cord-006788-kz8i4a6h	114	7	but	but	CC
cord-006788-kz8i4a6h	114	8	with	with	IN
cord-006788-kz8i4a6h	114	9	significant	significant	JJ
cord-006788-kz8i4a6h	114	10	side	side	NN
cord-006788-kz8i4a6h	114	11	effects	effect	NNS
cord-006788-kz8i4a6h	114	12	[	[	-LRB-
cord-006788-kz8i4a6h	114	13	70	70	CD
cord-006788-kz8i4a6h	114	14	]	]	-RRB-
cord-006788-kz8i4a6h	114	15	.	.	.
cord-006788-kz8i4a6h	115	1	In	in	IN
cord-006788-kz8i4a6h	115	2	a	a	DT
cord-006788-kz8i4a6h	115	3	phase	phase	NN
cord-006788-kz8i4a6h	115	4	2	2	CD
cord-006788-kz8i4a6h	115	5	trial	trial	NN
cord-006788-kz8i4a6h	115	6	in	in	IN
cord-006788-kz8i4a6h	115	7	patients	patient	NNS
cord-006788-kz8i4a6h	115	8	with	with	IN
cord-006788-kz8i4a6h	115	9	type	type	NN
cord-006788-kz8i4a6h	115	10	2	2	CD
cord-006788-kz8i4a6h	115	11	diabetes	diabetes	NN
cord-006788-kz8i4a6h	115	12	and	and	CC
cord-006788-kz8i4a6h	115	13	chronic	chronic	JJ
cord-006788-kz8i4a6h	115	14	idiopathic	idiopathic	JJ
cord-006788-kz8i4a6h	115	15	constipation	constipation	NN
cord-006788-kz8i4a6h	115	16	,	,	,
cord-006788-kz8i4a6h	115	17	NGM282	NGM282	NNPS
cord-006788-kz8i4a6h	115	18	significantly	significantly	RB
cord-006788-kz8i4a6h	115	19	improved	improve	VBD
cord-006788-kz8i4a6h	115	20	bowel	bowel	NN
cord-006788-kz8i4a6h	115	21	function	function	NN
cord-006788-kz8i4a6h	115	22	by	by	IN
cord-006788-kz8i4a6h	115	23	accelerating	accelerate	VBG
cord-006788-kz8i4a6h	115	24	gastric	gastric	JJ
cord-006788-kz8i4a6h	115	25	emptying	emptying	NN
cord-006788-kz8i4a6h	115	26	and	and	CC
cord-006788-kz8i4a6h	115	27	colonic	colonic	JJ
cord-006788-kz8i4a6h	115	28	transit	transit	NN
cord-006788-kz8i4a6h	115	29	[	[	-LRB-
cord-006788-kz8i4a6h	115	30	81	81	CD
cord-006788-kz8i4a6h	115	31	]	]	-RRB-
cord-006788-kz8i4a6h	115	32	.	.	.
cord-006788-kz8i4a6h	116	1	Furthermore	furthermore	RB
cord-006788-kz8i4a6h	116	2	,	,	,
cord-006788-kz8i4a6h	116	3	NGM282	NGM282	NNPS
cord-006788-kz8i4a6h	116	4	was	be	VBD
cord-006788-kz8i4a6h	116	5	further	further	RB
cord-006788-kz8i4a6h	116	6	tested	test	VBN
cord-006788-kz8i4a6h	116	7	in	in	IN
cord-006788-kz8i4a6h	116	8	mouse	mouse	NN
cord-006788-kz8i4a6h	116	9	models	model	NNS
cord-006788-kz8i4a6h	116	10	and	and	CC
cord-006788-kz8i4a6h	116	11	human	human	JJ
cord-006788-kz8i4a6h	116	12	patients	patient	NNS
cord-006788-kz8i4a6h	116	13	with	with	IN
cord-006788-kz8i4a6h	116	14	cholestasis	cholestasis	NN
cord-006788-kz8i4a6h	116	15	and	and	CC
cord-006788-kz8i4a6h	116	16	primary	primary	JJ
cord-006788-kz8i4a6h	116	17	biliary	biliary	JJ
cord-006788-kz8i4a6h	116	18	cholangitis	cholangitis	NN
cord-006788-kz8i4a6h	116	19	,	,	,
cord-006788-kz8i4a6h	116	20	showing	show	VBG
cord-006788-kz8i4a6h	116	21	efficacy	efficacy	NN
cord-006788-kz8i4a6h	116	22	in	in	IN
cord-006788-kz8i4a6h	116	23	significantly	significantly	RB
cord-006788-kz8i4a6h	116	24	reducing	reduce	VBG
cord-006788-kz8i4a6h	116	25	bile	bile	NN
cord-006788-kz8i4a6h	116	26	acid	acid	NN
cord-006788-kz8i4a6h	116	27	levels	level	NNS
cord-006788-kz8i4a6h	116	28	and	and	CC
cord-006788-kz8i4a6h	116	29	improving	improve	VBG
cord-006788-kz8i4a6h	116	30	hepatic	hepatic	JJ
cord-006788-kz8i4a6h	116	31	inflammatory	inflammatory	JJ
cord-006788-kz8i4a6h	116	32	injury	injury	NN
cord-006788-kz8i4a6h	116	33	and	and	CC
cord-006788-kz8i4a6h	116	34	fibrosis	fibrosis	NN
cord-006788-kz8i4a6h	116	35	[	[	-LRB-
cord-006788-kz8i4a6h	116	36	84	84	CD
cord-006788-kz8i4a6h	116	37	,	,	,
cord-006788-kz8i4a6h	116	38	88	88	CD
cord-006788-kz8i4a6h	116	39	,	,	,
cord-006788-kz8i4a6h	116	40	89	89	CD
cord-006788-kz8i4a6h	116	41	]	]	-RRB-
cord-006788-kz8i4a6h	116	42	.	.	.
cord-006788-kz8i4a6h	117	1	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	117	2	is	be	VBZ
cord-006788-kz8i4a6h	117	3	a	a	DT
cord-006788-kz8i4a6h	117	4	prime	prime	JJ
cord-006788-kz8i4a6h	117	5	lipid	lipid	NN
cord-006788-kz8i4a6h	117	6	catabolic	catabolic	NN
cord-006788-kz8i4a6h	117	7	factor	factor	NN
cord-006788-kz8i4a6h	117	8	that	that	WDT
cord-006788-kz8i4a6h	117	9	regulates	regulate	VBZ
cord-006788-kz8i4a6h	117	10	energy	energy	NN
cord-006788-kz8i4a6h	117	11	balance	balance	NN
cord-006788-kz8i4a6h	117	12	.	.	.
cord-006788-kz8i4a6h	118	1	However	however	RB
cord-006788-kz8i4a6h	118	2	,	,	,
cord-006788-kz8i4a6h	118	3	the	the	DT
cord-006788-kz8i4a6h	118	4	physiological	physiological	JJ
cord-006788-kz8i4a6h	118	5	roles	role	NNS
cord-006788-kz8i4a6h	118	6	and	and	CC
cord-006788-kz8i4a6h	118	7	pharmacological	pharmacological	JJ
cord-006788-kz8i4a6h	118	8	effects	effect	NNS
cord-006788-kz8i4a6h	118	9	of	of	IN
cord-006788-kz8i4a6h	118	10	FGF21-driven	FGF21-driven	NNP
cord-006788-kz8i4a6h	118	11	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	118	12	axes	axis	NNS
cord-006788-kz8i4a6h	118	13	are	be	VBP
cord-006788-kz8i4a6h	118	14	multifaceted	multifacete	VBN
cord-006788-kz8i4a6h	118	15	[	[	-LRB-
cord-006788-kz8i4a6h	118	16	2	2	CD
cord-006788-kz8i4a6h	118	17	,	,	,
cord-006788-kz8i4a6h	118	18	7	7	CD
cord-006788-kz8i4a6h	118	19	,	,	,
cord-006788-kz8i4a6h	118	20	90	90	CD
cord-006788-kz8i4a6h	118	21	]	]	-RRB-
cord-006788-kz8i4a6h	119	1	(	(	-LRB-
cord-006788-kz8i4a6h	119	2	Fig	Fig	NNP
cord-006788-kz8i4a6h	119	3	.	.	.
cord-006788-kz8i4a6h	119	4	3	3	CD
cord-006788-kz8i4a6h	119	5	)	)	-RRB-
cord-006788-kz8i4a6h	119	6	.	.	.
cord-006788-kz8i4a6h	120	1	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	120	2	was	be	VBD
cord-006788-kz8i4a6h	120	3	discovered	discover	VBN
cord-006788-kz8i4a6h	120	4	as	as	IN
cord-006788-kz8i4a6h	120	5	a	a	DT
cord-006788-kz8i4a6h	120	6	driver	driver	NN
cord-006788-kz8i4a6h	120	7	of	of	IN
cord-006788-kz8i4a6h	120	8	glucose	glucose	NN
cord-006788-kz8i4a6h	120	9	uptake	uptake	NN
cord-006788-kz8i4a6h	120	10	in	in	IN
cord-006788-kz8i4a6h	120	11	adipocytes	adipocyte	NNS
cord-006788-kz8i4a6h	120	12	and	and	CC
cord-006788-kz8i4a6h	120	13	a	a	DT
cord-006788-kz8i4a6h	120	14	PPARαdependent	pparαdependent	NN
cord-006788-kz8i4a6h	120	15	hepatic	hepatic	JJ
cord-006788-kz8i4a6h	120	16	starvation	starvation	NN
cord-006788-kz8i4a6h	120	17	hormone	hormone	NN
cord-006788-kz8i4a6h	120	18	[	[	-LRB-
cord-006788-kz8i4a6h	120	19	48	48	CD
cord-006788-kz8i4a6h	120	20	,	,	,
cord-006788-kz8i4a6h	120	21	50	50	CD
cord-006788-kz8i4a6h	120	22	,	,	,
cord-006788-kz8i4a6h	120	23	51	51	CD
cord-006788-kz8i4a6h	120	24	]	]	-RRB-
cord-006788-kz8i4a6h	120	25	.	.	.
cord-006788-kz8i4a6h	121	1	In	in	IN
cord-006788-kz8i4a6h	121	2	mice	mouse	NNS
cord-006788-kz8i4a6h	121	3	,	,	,
cord-006788-kz8i4a6h	121	4	FGF21	fgf21	JJ
cord-006788-kz8i4a6h	121	5	levels	level	NNS
cord-006788-kz8i4a6h	121	6	are	be	VBP
cord-006788-kz8i4a6h	121	7	induced	induce	VBN
cord-006788-kz8i4a6h	121	8	when	when	WRB
cord-006788-kz8i4a6h	121	9	calories	calorie	NNS
cord-006788-kz8i4a6h	121	10	are	be	VBP
cord-006788-kz8i4a6h	121	11	restricted	restrict	VBN
cord-006788-kz8i4a6h	121	12	or	or	CC
cord-006788-kz8i4a6h	121	13	when	when	WRB
cord-006788-kz8i4a6h	121	14	glucose	glucose	NN
cord-006788-kz8i4a6h	121	15	is	be	VBZ
cord-006788-kz8i4a6h	121	16	low	low	JJ
cord-006788-kz8i4a6h	121	17	to	to	TO
cord-006788-kz8i4a6h	121	18	allow	allow	VB
cord-006788-kz8i4a6h	121	19	fats	fat	NNS
cord-006788-kz8i4a6h	121	20	to	to	TO
cord-006788-kz8i4a6h	121	21	be	be	VB
cord-006788-kz8i4a6h	121	22	burned	burn	VBN
cord-006788-kz8i4a6h	121	23	for	for	IN
cord-006788-kz8i4a6h	121	24	energy	energy	NN
cord-006788-kz8i4a6h	121	25	supply	supply	NN
cord-006788-kz8i4a6h	121	26	.	.	.
cord-006788-kz8i4a6h	122	1	The	the	DT
cord-006788-kz8i4a6h	122	2	increasing	increase	VBG
cord-006788-kz8i4a6h	122	3	levels	level	NNS
cord-006788-kz8i4a6h	122	4	of	of	IN
cord-006788-kz8i4a6h	122	5	FGF21	fgf21	NN
cord-006788-kz8i4a6h	122	6	drive	drive	VBP
cord-006788-kz8i4a6h	122	7	diverse	diverse	JJ
cord-006788-kz8i4a6h	122	8	aspects	aspect	NNS
cord-006788-kz8i4a6h	122	9	of	of	IN
cord-006788-kz8i4a6h	122	10	the	the	DT
cord-006788-kz8i4a6h	122	11	adaptive	adaptive	JJ
cord-006788-kz8i4a6h	122	12	starvation	starvation	NN
cord-006788-kz8i4a6h	122	13	response	response	NN
cord-006788-kz8i4a6h	122	14	,	,	,
cord-006788-kz8i4a6h	122	15	including	include	VBG
cord-006788-kz8i4a6h	122	16	stimulation	stimulation	NN
cord-006788-kz8i4a6h	122	17	of	of	IN
cord-006788-kz8i4a6h	122	18	hepatic	hepatic	JJ
cord-006788-kz8i4a6h	122	19	fatty	fatty	JJ
cord-006788-kz8i4a6h	122	20	acid	acid	NN
cord-006788-kz8i4a6h	122	21	oxidative	oxidative	RB
cord-006788-kz8i4a6h	122	22	for	for	IN
cord-006788-kz8i4a6h	122	23	ketone	ketone	NN
cord-006788-kz8i4a6h	122	24	body	body	NN
cord-006788-kz8i4a6h	122	25	production	production	NN
cord-006788-kz8i4a6h	122	26	during	during	IN
cord-006788-kz8i4a6h	122	27	prolonged	prolonged	JJ
cord-006788-kz8i4a6h	122	28	fasting	fasting	NN
cord-006788-kz8i4a6h	122	29	and	and	CC
cord-006788-kz8i4a6h	122	30	starvation	starvation	NN
cord-006788-kz8i4a6h	122	31	.	.	.
cord-006788-kz8i4a6h	123	1	Whether	whether	IN
cord-006788-kz8i4a6h	123	2	this	this	DT
cord-006788-kz8i4a6h	123	3	action	action	NN
cord-006788-kz8i4a6h	123	4	of	of	IN
cord-006788-kz8i4a6h	123	5	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	123	6	is	be	VBZ
cord-006788-kz8i4a6h	123	7	autocrine	autocrine	NN
cord-006788-kz8i4a6h	123	8	/	/	SYM
cord-006788-kz8i4a6h	123	9	paracrine	paracrine	NN
cord-006788-kz8i4a6h	123	10	in	in	IN
cord-006788-kz8i4a6h	123	11	the	the	DT
cord-006788-kz8i4a6h	123	12	liver	liver	NN
cord-006788-kz8i4a6h	123	13	or	or	CC
cord-006788-kz8i4a6h	123	14	endocrine	endocrine	NN
cord-006788-kz8i4a6h	123	15	in	in	IN
cord-006788-kz8i4a6h	123	16	adipose	adipose	JJ
cord-006788-kz8i4a6h	123	17	tissues	tissue	NNS
cord-006788-kz8i4a6h	123	18	through	through	IN
cord-006788-kz8i4a6h	123	19	adipose	adipose	JJ
cord-006788-kz8i4a6h	123	20	lipolysis	lipolysis	NN
cord-006788-kz8i4a6h	123	21	and	and	CC
cord-006788-kz8i4a6h	124	1	fatty	fatty	JJ
cord-006788-kz8i4a6h	124	2	acid	acid	NN
cord-006788-kz8i4a6h	124	3	oxidation	oxidation	NN
cord-006788-kz8i4a6h	124	4	is	be	VBZ
cord-006788-kz8i4a6h	124	5	a	a	DT
cord-006788-kz8i4a6h	124	6	matter	matter	NN
cord-006788-kz8i4a6h	124	7	of	of	IN
cord-006788-kz8i4a6h	124	8	debate	debate	NN
cord-006788-kz8i4a6h	124	9	.	.	.
cord-006788-kz8i4a6h	125	1	The	the	DT
cord-006788-kz8i4a6h	125	2	liver	liver	NN
cord-006788-kz8i4a6h	125	3	is	be	VBZ
cord-006788-kz8i4a6h	125	4	a	a	DT
cord-006788-kz8i4a6h	125	5	major	major	JJ
cord-006788-kz8i4a6h	125	6	contributor	contributor	NN
cord-006788-kz8i4a6h	125	7	to	to	IN
cord-006788-kz8i4a6h	125	8	the	the	DT
cord-006788-kz8i4a6h	125	9	circulating	circulate	VBG
cord-006788-kz8i4a6h	125	10	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	125	11	levels	level	NNS
cord-006788-kz8i4a6h	125	12	,	,	,
cord-006788-kz8i4a6h	125	13	which	which	WDT
cord-006788-kz8i4a6h	125	14	is	be	VBZ
cord-006788-kz8i4a6h	125	15	associated	associate	VBN
cord-006788-kz8i4a6h	125	16	with	with	IN
cord-006788-kz8i4a6h	125	17	hepatic	hepatic	JJ
cord-006788-kz8i4a6h	125	18	fat	fat	NN
cord-006788-kz8i4a6h	125	19	content	content	NN
cord-006788-kz8i4a6h	125	20	and	and	CC
cord-006788-kz8i4a6h	125	21	adiposity	adiposity	NN
cord-006788-kz8i4a6h	125	22	but	but	CC
cord-006788-kz8i4a6h	125	23	inversely	inversely	RB
cord-006788-kz8i4a6h	125	24	associated	associate	VBN
cord-006788-kz8i4a6h	125	25	with	with	IN
cord-006788-kz8i4a6h	125	26	serum	serum	NN
cord-006788-kz8i4a6h	125	27	glucose	glucose	NN
cord-006788-kz8i4a6h	125	28	levels	level	NNS
cord-006788-kz8i4a6h	125	29	[	[	-LRB-
cord-006788-kz8i4a6h	125	30	91	91	CD
cord-006788-kz8i4a6h	125	31	]	]	-RRB-
cord-006788-kz8i4a6h	125	32	[	[	-LRB-
cord-006788-kz8i4a6h	125	33	92	92	CD
cord-006788-kz8i4a6h	125	34	]	]	-RRB-
cord-006788-kz8i4a6h	125	35	[	[	-LRB-
cord-006788-kz8i4a6h	125	36	93	93	CD
cord-006788-kz8i4a6h	125	37	]	]	-RRB-
cord-006788-kz8i4a6h	125	38	.	.	.
cord-006788-kz8i4a6h	126	1	The	the	DT
cord-006788-kz8i4a6h	126	2	hepatic	hepatic	JJ
cord-006788-kz8i4a6h	126	3	expression	expression	NN
cord-006788-kz8i4a6h	126	4	of	of	IN
cord-006788-kz8i4a6h	126	5	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	126	6	is	be	VBZ
cord-006788-kz8i4a6h	126	7	responsive	responsive	JJ
cord-006788-kz8i4a6h	126	8	not	not	RB
cord-006788-kz8i4a6h	126	9	only	only	RB
cord-006788-kz8i4a6h	126	10	to	to	IN
cord-006788-kz8i4a6h	126	11	starvation	starvation	NN
cord-006788-kz8i4a6h	126	12	but	but	CC
cord-006788-kz8i4a6h	126	13	also	also	RB
cord-006788-kz8i4a6h	126	14	to	to	IN
cord-006788-kz8i4a6h	126	15	a	a	DT
cord-006788-kz8i4a6h	126	16	broad	broad	JJ
cord-006788-kz8i4a6h	126	17	spectrum	spectrum	NN
cord-006788-kz8i4a6h	126	18	of	of	IN
cord-006788-kz8i4a6h	126	19	cellular	cellular	JJ
cord-006788-kz8i4a6h	126	20	,	,	,
cord-006788-kz8i4a6h	126	21	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	126	22	,	,	,
cord-006788-kz8i4a6h	126	23	or	or	CC
cord-006788-kz8i4a6h	126	24	pathological	pathological	JJ
cord-006788-kz8i4a6h	126	25	changes	change	NNS
cord-006788-kz8i4a6h	126	26	in	in	IN
cord-006788-kz8i4a6h	126	27	the	the	DT
cord-006788-kz8i4a6h	126	28	liver	liver	NN
cord-006788-kz8i4a6h	126	29	as	as	RB
cord-006788-kz8i4a6h	126	30	well	well	RB
cord-006788-kz8i4a6h	126	31	as	as	IN
cord-006788-kz8i4a6h	126	32	systemic	systemic	JJ
cord-006788-kz8i4a6h	126	33	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	126	34	perturbations	perturbation	NNS
cord-006788-kz8i4a6h	126	35	[	[	-LRB-
cord-006788-kz8i4a6h	126	36	7	7	CD
cord-006788-kz8i4a6h	126	37	,	,	,
cord-006788-kz8i4a6h	126	38	69	69	CD
cord-006788-kz8i4a6h	126	39	,	,	,
cord-006788-kz8i4a6h	126	40	94	94	CD
cord-006788-kz8i4a6h	126	41	]	]	-RRB-
cord-006788-kz8i4a6h	126	42	.	.	.
cord-006788-kz8i4a6h	127	1	As	as	IN
cord-006788-kz8i4a6h	127	2	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	127	3	is	be	VBZ
cord-006788-kz8i4a6h	127	4	incapable	incapable	JJ
cord-006788-kz8i4a6h	127	5	of	of	IN
cord-006788-kz8i4a6h	127	6	activating	activate	VBG
cord-006788-kz8i4a6h	127	7	FGFR4-KLB	FGFR4-KLB	NNP
cord-006788-kz8i4a6h	127	8	complex	complex	JJ
cord-006788-kz8i4a6h	127	9	[	[	-LRB-
cord-006788-kz8i4a6h	127	10	67	67	CD
cord-006788-kz8i4a6h	127	11	]	]	-RRB-
cord-006788-kz8i4a6h	127	12	,	,	,
cord-006788-kz8i4a6h	127	13	which	which	WDT
cord-006788-kz8i4a6h	127	14	is	be	VBZ
cord-006788-kz8i4a6h	127	15	predominant	predominant	JJ
cord-006788-kz8i4a6h	127	16	in	in	IN
cord-006788-kz8i4a6h	127	17	the	the	DT
cord-006788-kz8i4a6h	127	18	liver	liver	NN
cord-006788-kz8i4a6h	127	19	that	that	WDT
cord-006788-kz8i4a6h	127	20	expresses	express	VBZ
cord-006788-kz8i4a6h	127	21	FGFR1-KLB	fgfr1-klb	NN
cord-006788-kz8i4a6h	127	22	with	with	IN
cord-006788-kz8i4a6h	127	23	lower	low	JJR
cord-006788-kz8i4a6h	127	24	levels	level	NNS
cord-006788-kz8i4a6h	127	25	,	,	,
cord-006788-kz8i4a6h	127	26	hepatic	hepatic	JJ
cord-006788-kz8i4a6h	127	27	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	127	28	acts	act	NNS
cord-006788-kz8i4a6h	127	29	mainly	mainly	RB
cord-006788-kz8i4a6h	127	30	as	as	IN
cord-006788-kz8i4a6h	127	31	an	an	DT
cord-006788-kz8i4a6h	127	32	endocrine	endocrine	JJ
cord-006788-kz8i4a6h	127	33	factor	factor	NN
cord-006788-kz8i4a6h	127	34	to	to	TO
cord-006788-kz8i4a6h	127	35	drive	drive	VB
cord-006788-kz8i4a6h	127	36	the	the	DT
cord-006788-kz8i4a6h	127	37	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	127	38	pathways	pathway	NNS
cord-006788-kz8i4a6h	127	39	in	in	IN
cord-006788-kz8i4a6h	127	40	peripheral	peripheral	JJ
cord-006788-kz8i4a6h	127	41	tissues	tissue	NNS
cord-006788-kz8i4a6h	127	42	,	,	,
cord-006788-kz8i4a6h	127	43	including	include	VBG
cord-006788-kz8i4a6h	127	44	WAT	WAT	NNP
cord-006788-kz8i4a6h	127	45	,	,	,
cord-006788-kz8i4a6h	127	46	BAT	bat	NN
cord-006788-kz8i4a6h	127	47	,	,	,
cord-006788-kz8i4a6h	127	48	muscle	muscle	NN
cord-006788-kz8i4a6h	127	49	,	,	,
cord-006788-kz8i4a6h	127	50	heart	heart	NN
cord-006788-kz8i4a6h	127	51	,	,	,
cord-006788-kz8i4a6h	127	52	kidney	kidney	NN
cord-006788-kz8i4a6h	127	53	,	,	,
cord-006788-kz8i4a6h	127	54	and	and	CC
cord-006788-kz8i4a6h	127	55	CNS	CNS	NNP
cord-006788-kz8i4a6h	127	56	that	that	WDT
cord-006788-kz8i4a6h	127	57	express	express	VBP
cord-006788-kz8i4a6h	127	58	high	high	JJ
cord-006788-kz8i4a6h	127	59	levels	level	NNS
cord-006788-kz8i4a6h	127	60	of	of	IN
cord-006788-kz8i4a6h	127	61	FGFR1/2/3-KLB	FGFR1/2/3-KLB	NNP
cord-006788-kz8i4a6h	127	62	,	,	,
cord-006788-kz8i4a6h	127	63	leading	lead	VBG
cord-006788-kz8i4a6h	127	64	to	to	IN
cord-006788-kz8i4a6h	127	65	the	the	DT
cord-006788-kz8i4a6h	127	66	correction	correction	NN
cord-006788-kz8i4a6h	127	67	of	of	IN
cord-006788-kz8i4a6h	127	68	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	127	69	derangements	derangement	NNS
cord-006788-kz8i4a6h	127	70	and	and	CC
cord-006788-kz8i4a6h	127	71	amelioration	amelioration	NN
cord-006788-kz8i4a6h	127	72	of	of	IN
cord-006788-kz8i4a6h	127	73	metaflammation	metaflammation	NN
cord-006788-kz8i4a6h	127	74	and	and	CC
cord-006788-kz8i4a6h	127	75	stress	stress	NN
cord-006788-kz8i4a6h	127	76	damage	damage	NN
cord-006788-kz8i4a6h	128	1	(	(	-LRB-
cord-006788-kz8i4a6h	128	2	Fig	Fig	NNP
cord-006788-kz8i4a6h	128	3	.	.	.
cord-006788-kz8i4a6h	129	1	3	3	LS
cord-006788-kz8i4a6h	129	2	)	)	-RRB-
cord-006788-kz8i4a6h	129	3	[	[	-LRB-
cord-006788-kz8i4a6h	129	4	7,94	7,94	CD
cord-006788-kz8i4a6h	129	5	]	]	-RRB-
cord-006788-kz8i4a6h	129	6	.	.	.
cord-006788-kz8i4a6h	130	1	Although	although	IN
cord-006788-kz8i4a6h	130	2	the	the	DT
cord-006788-kz8i4a6h	130	3	liver	liver	NN
cord-006788-kz8i4a6h	130	4	is	be	VBZ
cord-006788-kz8i4a6h	130	5	unlikely	unlikely	JJ
cord-006788-kz8i4a6h	130	6	a	a	DT
cord-006788-kz8i4a6h	130	7	major	major	JJ
cord-006788-kz8i4a6h	130	8	direct	direct	JJ
cord-006788-kz8i4a6h	130	9	target	target	NN
cord-006788-kz8i4a6h	130	10	of	of	IN
cord-006788-kz8i4a6h	130	11	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	130	12	,	,	,
cord-006788-kz8i4a6h	130	13	the	the	DT
cord-006788-kz8i4a6h	130	14	effects	effect	NNS
cord-006788-kz8i4a6h	130	15	of	of	IN
cord-006788-kz8i4a6h	130	16	FGF21	fgf21	NN
cord-006788-kz8i4a6h	130	17	on	on	IN
cord-006788-kz8i4a6h	130	18	the	the	DT
cord-006788-kz8i4a6h	130	19	liver	liver	NN
cord-006788-kz8i4a6h	130	20	are	be	VBP
cord-006788-kz8i4a6h	130	21	prominent	prominent	JJ
cord-006788-kz8i4a6h	130	22	.	.	.
cord-006788-kz8i4a6h	131	1	In	in	IN
cord-006788-kz8i4a6h	131	2	addition	addition	NN
cord-006788-kz8i4a6h	131	3	to	to	IN
cord-006788-kz8i4a6h	131	4	its	-PRON-	PRP$
cord-006788-kz8i4a6h	131	5	role	role	NN
cord-006788-kz8i4a6h	131	6	as	as	IN
cord-006788-kz8i4a6h	131	7	a	a	DT
cord-006788-kz8i4a6h	131	8	regulator	regulator	NN
cord-006788-kz8i4a6h	131	9	of	of	IN
cord-006788-kz8i4a6h	131	10	integrated	integrated	JJ
cord-006788-kz8i4a6h	131	11	hepatic	hepatic	JJ
cord-006788-kz8i4a6h	131	12	metabolism	metabolism	NN
cord-006788-kz8i4a6h	131	13	in	in	IN
cord-006788-kz8i4a6h	131	14	multiple	multiple	JJ
cord-006788-kz8i4a6h	131	15	aspects	aspect	NNS
cord-006788-kz8i4a6h	131	16	[	[	-LRB-
cord-006788-kz8i4a6h	131	17	48	48	CD
cord-006788-kz8i4a6h	131	18	,	,	,
cord-006788-kz8i4a6h	131	19	50	50	CD
cord-006788-kz8i4a6h	131	20	,	,	,
cord-006788-kz8i4a6h	131	21	[	[	-LRB-
cord-006788-kz8i4a6h	131	22	95	95	CD
cord-006788-kz8i4a6h	131	23	]	]	-RRB-
cord-006788-kz8i4a6h	131	24	[	[	-LRB-
cord-006788-kz8i4a6h	131	25	96	96	CD
cord-006788-kz8i4a6h	131	26	]	]	-RRB-
cord-006788-kz8i4a6h	131	27	[	[	-LRB-
cord-006788-kz8i4a6h	131	28	97	97	CD
cord-006788-kz8i4a6h	131	29	]	]	-RRB-
cord-006788-kz8i4a6h	131	30	[	[	-LRB-
cord-006788-kz8i4a6h	131	31	98	98	CD
cord-006788-kz8i4a6h	131	32	]	]	-RRB-
cord-006788-kz8i4a6h	131	33	,	,	,
cord-006788-kz8i4a6h	131	34	including	include	VBG
cord-006788-kz8i4a6h	131	35	fatty	fatty	JJ
cord-006788-kz8i4a6h	131	36	acid	acid	NN
cord-006788-kz8i4a6h	131	37	oxidation	oxidation	NN
cord-006788-kz8i4a6h	131	38	,	,	,
cord-006788-kz8i4a6h	131	39	ketogenesis	ketogenesis	NN
cord-006788-kz8i4a6h	131	40	,	,	,
cord-006788-kz8i4a6h	131	41	gluconeogenesis	gluconeogenesis	NN
cord-006788-kz8i4a6h	131	42	,	,	,
cord-006788-kz8i4a6h	131	43	and	and	CC
cord-006788-kz8i4a6h	131	44	macronutrient	macronutrient	NN
cord-006788-kz8i4a6h	131	45	preference	preference	NN
cord-006788-kz8i4a6h	131	46	,	,	,
cord-006788-kz8i4a6h	131	47	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	131	48	counteracts	counteract	VBZ
cord-006788-kz8i4a6h	131	49	hepatic	hepatic	JJ
cord-006788-kz8i4a6h	131	50	pathologies	pathology	NNS
cord-006788-kz8i4a6h	131	51	in	in	IN
cord-006788-kz8i4a6h	131	52	response	response	NN
cord-006788-kz8i4a6h	131	53	to	to	IN
cord-006788-kz8i4a6h	131	54	a	a	DT
cord-006788-kz8i4a6h	131	55	number	number	NN
cord-006788-kz8i4a6h	131	56	of	of	IN
cord-006788-kz8i4a6h	131	57	nutritional	nutritional	JJ
cord-006788-kz8i4a6h	131	58	and	and	CC
cord-006788-kz8i4a6h	131	59	chemical	chemical	JJ
cord-006788-kz8i4a6h	131	60	insults	insult	NNS
cord-006788-kz8i4a6h	131	61	,	,	,
cord-006788-kz8i4a6h	131	62	including	include	VBG
cord-006788-kz8i4a6h	131	63	ketogenic	ketogenic	JJ
cord-006788-kz8i4a6h	131	64	diet	diet	NN
cord-006788-kz8i4a6h	131	65	,	,	,
cord-006788-kz8i4a6h	131	66	high	high	JJ
cord-006788-kz8i4a6h	131	67	fat	fat	NN
cord-006788-kz8i4a6h	131	68	diet	diet	NN
cord-006788-kz8i4a6h	131	69	,	,	,
cord-006788-kz8i4a6h	131	70	high	high	JJ
cord-006788-kz8i4a6h	131	71	fructose	fructose	NN
cord-006788-kz8i4a6h	131	72	diet	diet	NN
cord-006788-kz8i4a6h	131	73	,	,	,
cord-006788-kz8i4a6h	131	74	methionine	methionine	NN
cord-006788-kz8i4a6h	131	75	and	and	CC
cord-006788-kz8i4a6h	131	76	choline	choline	NN
cord-006788-kz8i4a6h	131	77	deficient	deficient	JJ
cord-006788-kz8i4a6h	131	78	diet	diet	NN
cord-006788-kz8i4a6h	131	79	,	,	,
cord-006788-kz8i4a6h	131	80	ethanol	ethanol	NN
cord-006788-kz8i4a6h	131	81	-	-	HYPH
cord-006788-kz8i4a6h	131	82	supplemented	supplement	VBN
cord-006788-kz8i4a6h	131	83	diet	diet	NN
cord-006788-kz8i4a6h	131	84	,	,	,
cord-006788-kz8i4a6h	131	85	and	and	CC
cord-006788-kz8i4a6h	131	86	diethylnitrosamine	diethylnitrosamine	NNP
cord-006788-kz8i4a6h	131	87	[	[	-LRB-
cord-006788-kz8i4a6h	131	88	99	99	CD
cord-006788-kz8i4a6h	131	89	]	]	-RRB-
cord-006788-kz8i4a6h	131	90	[	[	-LRB-
cord-006788-kz8i4a6h	131	91	100	100	CD
cord-006788-kz8i4a6h	131	92	]	]	-RRB-
cord-006788-kz8i4a6h	131	93	[	[	-LRB-
cord-006788-kz8i4a6h	131	94	101	101	CD
cord-006788-kz8i4a6h	131	95	]	]	-RRB-
cord-006788-kz8i4a6h	131	96	[	[	-LRB-
cord-006788-kz8i4a6h	131	97	102	102	CD
cord-006788-kz8i4a6h	131	98	]	]	-RRB-
cord-006788-kz8i4a6h	131	99	[	[	-LRB-
cord-006788-kz8i4a6h	131	100	103	103	CD
cord-006788-kz8i4a6h	131	101	]	]	-RRB-
cord-006788-kz8i4a6h	131	102	.	.	.
cord-006788-kz8i4a6h	132	1	Under	under	IN
cord-006788-kz8i4a6h	132	2	a	a	DT
cord-006788-kz8i4a6h	132	3	chronic	chronic	JJ
cord-006788-kz8i4a6h	132	4	obesogenic	obesogenic	NN
cord-006788-kz8i4a6h	132	5	diet	diet	NN
cord-006788-kz8i4a6h	132	6	,	,	,
cord-006788-kz8i4a6h	132	7	FGF21-deficient	fgf21-deficient	CD
cord-006788-kz8i4a6h	132	8	mice	mouse	NNS
cord-006788-kz8i4a6h	132	9	developed	develop	VBD
cord-006788-kz8i4a6h	132	10	a	a	DT
cord-006788-kz8i4a6h	132	11	spectrum	spectrum	NN
cord-006788-kz8i4a6h	132	12	of	of	IN
cord-006788-kz8i4a6h	132	13	progressive	progressive	JJ
cord-006788-kz8i4a6h	132	14	fatty	fatty	JJ
cord-006788-kz8i4a6h	132	15	liver	liver	NN
cord-006788-kz8i4a6h	132	16	disease	disease	NN
cord-006788-kz8i4a6h	132	17	,	,	,
cord-006788-kz8i4a6h	132	18	including	include	VBG
cord-006788-kz8i4a6h	132	19	simple	simple	JJ
cord-006788-kz8i4a6h	132	20	hepatosteatosis	hepatosteatosis	NN
cord-006788-kz8i4a6h	132	21	to	to	IN
cord-006788-kz8i4a6h	132	22	NASH	NASH	NNP
cord-006788-kz8i4a6h	132	23	,	,	,
cord-006788-kz8i4a6h	132	24	fibrosis	fibrosis	NN
cord-006788-kz8i4a6h	132	25	,	,	,
cord-006788-kz8i4a6h	132	26	and	and	CC
cord-006788-kz8i4a6h	132	27	HCC	HCC	NNP
cord-006788-kz8i4a6h	132	28	,	,	,
cord-006788-kz8i4a6h	132	29	which	which	WDT
cord-006788-kz8i4a6h	132	30	is	be	VBZ
cord-006788-kz8i4a6h	132	31	the	the	DT
cord-006788-kz8i4a6h	132	32	most	most	RBS
cord-006788-kz8i4a6h	132	33	lethal	lethal	JJ
cord-006788-kz8i4a6h	132	34	complication	complication	NN
cord-006788-kz8i4a6h	132	35	of	of	IN
cord-006788-kz8i4a6h	132	36	this	this	DT
cord-006788-kz8i4a6h	132	37	disorder	disorder	NN
cord-006788-kz8i4a6h	132	38	.	.	.
cord-006788-kz8i4a6h	133	1	These	these	DT
cord-006788-kz8i4a6h	133	2	findings	finding	NNS
cord-006788-kz8i4a6h	133	3	highlight	highlight	VBP
cord-006788-kz8i4a6h	133	4	the	the	DT
cord-006788-kz8i4a6h	133	5	role	role	NN
cord-006788-kz8i4a6h	133	6	of	of	IN
cord-006788-kz8i4a6h	133	7	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	133	8	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	133	9	axis	axis	NN
cord-006788-kz8i4a6h	133	10	as	as	IN
cord-006788-kz8i4a6h	133	11	a	a	DT
cord-006788-kz8i4a6h	133	12	defensive	defensive	JJ
cord-006788-kz8i4a6h	133	13	barrier	barrier	NN
cord-006788-kz8i4a6h	133	14	for	for	IN
cord-006788-kz8i4a6h	133	15	the	the	DT
cord-006788-kz8i4a6h	133	16	deleterious	deleterious	JJ
cord-006788-kz8i4a6h	133	17	stress	stress	NN
cord-006788-kz8i4a6h	133	18	damage	damage	NN
cord-006788-kz8i4a6h	133	19	caused	cause	VBN
cord-006788-kz8i4a6h	133	20	by	by	IN
cord-006788-kz8i4a6h	133	21	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	133	22	disorders	disorder	NNS
cord-006788-kz8i4a6h	133	23	in	in	IN
cord-006788-kz8i4a6h	133	24	the	the	DT
cord-006788-kz8i4a6h	133	25	liver	liver	NN
cord-006788-kz8i4a6h	133	26	[	[	-LRB-
cord-006788-kz8i4a6h	133	27	104	104	CD
cord-006788-kz8i4a6h	133	28	]	]	-RRB-
cord-006788-kz8i4a6h	133	29	.	.	.
cord-006788-kz8i4a6h	134	1	Current	current	JJ
cord-006788-kz8i4a6h	134	2	clinical	clinical	JJ
cord-006788-kz8i4a6h	134	3	trials	trial	NNS
cord-006788-kz8i4a6h	134	4	with	with	IN
cord-006788-kz8i4a6h	134	5	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	134	6	analogs	analog	NNS
cord-006788-kz8i4a6h	134	7	show	show	VBP
cord-006788-kz8i4a6h	134	8	promising	promising	JJ
cord-006788-kz8i4a6h	134	9	efficacy	efficacy	NN
cord-006788-kz8i4a6h	134	10	against	against	IN
cord-006788-kz8i4a6h	134	11	NAFLD	NAFLD	NNP
cord-006788-kz8i4a6h	134	12	,	,	,
cord-006788-kz8i4a6h	134	13	NASH	NASH	NNP
cord-006788-kz8i4a6h	134	14	,	,	,
cord-006788-kz8i4a6h	134	15	and	and	CC
cord-006788-kz8i4a6h	134	16	fibrosis	fibrosis	NN
cord-006788-kz8i4a6h	134	17	without	without	IN
cord-006788-kz8i4a6h	134	18	noticeable	noticeable	JJ
cord-006788-kz8i4a6h	134	19	adverse	adverse	JJ
cord-006788-kz8i4a6h	134	20	side	side	NN
cord-006788-kz8i4a6h	134	21	effects	effect	NNS
cord-006788-kz8i4a6h	134	22	[	[	-LRB-
cord-006788-kz8i4a6h	134	23	73	73	CD
cord-006788-kz8i4a6h	134	24	]	]	-RRB-
cord-006788-kz8i4a6h	134	25	.	.	.
cord-006788-kz8i4a6h	135	1	Acting	act	VBG
cord-006788-kz8i4a6h	135	2	on	on	IN
cord-006788-kz8i4a6h	135	3	WAT	WAT	NNP
cord-006788-kz8i4a6h	135	4	and	and	CC
cord-006788-kz8i4a6h	135	5	BAT	BAT	NNP
cord-006788-kz8i4a6h	135	6	,	,	,
cord-006788-kz8i4a6h	135	7	the	the	DT
cord-006788-kz8i4a6h	135	8	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	135	9	axis	axis	NN
cord-006788-kz8i4a6h	135	10	drives	drive	VBZ
cord-006788-kz8i4a6h	135	11	an	an	DT
cord-006788-kz8i4a6h	135	12	array	array	NN
cord-006788-kz8i4a6h	135	13	of	of	IN
cord-006788-kz8i4a6h	135	14	catabolic	catabolic	JJ
cord-006788-kz8i4a6h	135	15	effects	effect	NNS
cord-006788-kz8i4a6h	135	16	,	,	,
cord-006788-kz8i4a6h	135	17	including	include	VBG
cord-006788-kz8i4a6h	135	18	insulin	insulin	NN
cord-006788-kz8i4a6h	135	19	-	-	HYPH
cord-006788-kz8i4a6h	135	20	independent	independent	JJ
cord-006788-kz8i4a6h	135	21	glucose	glucose	NN
cord-006788-kz8i4a6h	135	22	uptake	uptake	NN
cord-006788-kz8i4a6h	135	23	,	,	,
cord-006788-kz8i4a6h	135	24	lipid	lipid	NN
cord-006788-kz8i4a6h	135	25	droplet	droplet	NN
cord-006788-kz8i4a6h	135	26	expansion	expansion	NN
cord-006788-kz8i4a6h	135	27	inhibition	inhibition	NN
cord-006788-kz8i4a6h	135	28	,	,	,
cord-006788-kz8i4a6h	135	29	lipolysis	lipolysis	NN
cord-006788-kz8i4a6h	135	30	,	,	,
cord-006788-kz8i4a6h	135	31	fatty	fatty	JJ
cord-006788-kz8i4a6h	135	32	acid	acid	NN
cord-006788-kz8i4a6h	135	33	oxidation	oxidation	NN
cord-006788-kz8i4a6h	135	34	,	,	,
cord-006788-kz8i4a6h	135	35	white	white	JJ
cord-006788-kz8i4a6h	135	36	adipocyte	adipocyte	NN
cord-006788-kz8i4a6h	135	37	beigeing	beigeing	NN
cord-006788-kz8i4a6h	135	38	,	,	,
cord-006788-kz8i4a6h	135	39	and	and	CC
cord-006788-kz8i4a6h	135	40	thermogenic	thermogenic	JJ
cord-006788-kz8i4a6h	135	41	dissipation	dissipation	NN
cord-006788-kz8i4a6h	135	42	of	of	IN
cord-006788-kz8i4a6h	135	43	energy	energy	NN
cord-006788-kz8i4a6h	135	44	[	[	-LRB-
cord-006788-kz8i4a6h	135	45	79	79	CD
cord-006788-kz8i4a6h	135	46	,	,	,
cord-006788-kz8i4a6h	135	47	105	105	CD
cord-006788-kz8i4a6h	135	48	,	,	,
cord-006788-kz8i4a6h	135	49	106	106	CD
cord-006788-kz8i4a6h	135	50	]	]	-RRB-
cord-006788-kz8i4a6h	135	51	.	.	.
cord-006788-kz8i4a6h	136	1	This	this	DT
cord-006788-kz8i4a6h	136	2	route	route	NN
cord-006788-kz8i4a6h	136	3	of	of	IN
cord-006788-kz8i4a6h	136	4	action	action	NN
cord-006788-kz8i4a6h	136	5	has	have	VBZ
cord-006788-kz8i4a6h	136	6	been	be	VBN
cord-006788-kz8i4a6h	136	7	proposed	propose	VBN
cord-006788-kz8i4a6h	136	8	as	as	IN
cord-006788-kz8i4a6h	136	9	a	a	DT
cord-006788-kz8i4a6h	136	10	major	major	JJ
cord-006788-kz8i4a6h	136	11	endocrine	endocrine	JJ
cord-006788-kz8i4a6h	136	12	axis	axis	NN
cord-006788-kz8i4a6h	136	13	of	of	IN
cord-006788-kz8i4a6h	136	14	FGF21	fgf21	NN
cord-006788-kz8i4a6h	136	15	for	for	IN
cord-006788-kz8i4a6h	136	16	insulin	insulin	NN
cord-006788-kz8i4a6h	136	17	sensitization	sensitization	NN
cord-006788-kz8i4a6h	136	18	;	;	:
cord-006788-kz8i4a6h	136	19	lowering	lowering	NN
cord-006788-kz8i4a6h	136	20	of	of	IN
cord-006788-kz8i4a6h	136	21	systemic	systemic	JJ
cord-006788-kz8i4a6h	136	22	glucose	glucose	NN
cord-006788-kz8i4a6h	136	23	,	,	,
cord-006788-kz8i4a6h	136	24	triacylglycerol	triacylglycerol	NN
cord-006788-kz8i4a6h	136	25	,	,	,
cord-006788-kz8i4a6h	136	26	and	and	CC
cord-006788-kz8i4a6h	136	27	LDL	ldl	NN
cord-006788-kz8i4a6h	136	28	;	;	:
cord-006788-kz8i4a6h	136	29	fighting	fight	VBG
cord-006788-kz8i4a6h	136	30	against	against	IN
cord-006788-kz8i4a6h	136	31	obesity	obesity	NN
cord-006788-kz8i4a6h	136	32	,	,	,
cord-006788-kz8i4a6h	136	33	diabetes	diabetes	NN
cord-006788-kz8i4a6h	136	34	,	,	,
cord-006788-kz8i4a6h	136	35	fatty	fatty	JJ
cord-006788-kz8i4a6h	136	36	liver	liver	NN
cord-006788-kz8i4a6h	136	37	diseases	disease	NNS
cord-006788-kz8i4a6h	136	38	,	,	,
cord-006788-kz8i4a6h	136	39	hyperlipidemia	hyperlipidemia	NN
cord-006788-kz8i4a6h	136	40	,	,	,
cord-006788-kz8i4a6h	136	41	and	and	CC
cord-006788-kz8i4a6h	136	42	associated	associated	JJ
cord-006788-kz8i4a6h	136	43	comorbidities	comorbiditie	NNS
cord-006788-kz8i4a6h	136	44	;	;	:
cord-006788-kz8i4a6h	136	45	and	and	CC
cord-006788-kz8i4a6h	136	46	achieving	achieve	VBG
cord-006788-kz8i4a6h	136	47	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	136	48	health	health	NN
cord-006788-kz8i4a6h	136	49	[	[	-LRB-
cord-006788-kz8i4a6h	136	50	2	2	CD
cord-006788-kz8i4a6h	136	51	,	,	,
cord-006788-kz8i4a6h	136	52	73	73	CD
cord-006788-kz8i4a6h	136	53	,	,	,
cord-006788-kz8i4a6h	136	54	74	74	CD
cord-006788-kz8i4a6h	136	55	,	,	,
cord-006788-kz8i4a6h	136	56	107	107	CD
cord-006788-kz8i4a6h	136	57	]	]	-RRB-
cord-006788-kz8i4a6h	136	58	.	.	.
cord-006788-kz8i4a6h	137	1	Some	some	DT
cord-006788-kz8i4a6h	137	2	of	of	IN
cord-006788-kz8i4a6h	137	3	these	these	DT
cord-006788-kz8i4a6h	137	4	effects	effect	NNS
cord-006788-kz8i4a6h	137	5	are	be	VBP
cord-006788-kz8i4a6h	137	6	likely	likely	RB
cord-006788-kz8i4a6h	137	7	mediated	mediate	VBN
cord-006788-kz8i4a6h	137	8	by	by	IN
cord-006788-kz8i4a6h	137	9	adipokines	adipokine	NNS
cord-006788-kz8i4a6h	137	10	,	,	,
cord-006788-kz8i4a6h	137	11	such	such	JJ
cord-006788-kz8i4a6h	137	12	as	as	IN
cord-006788-kz8i4a6h	137	13	CCL11	CCL11	NNP
cord-006788-kz8i4a6h	137	14	and	and	CC
cord-006788-kz8i4a6h	137	15	adiponectin	adiponectin	NN
cord-006788-kz8i4a6h	137	16	,	,	,
cord-006788-kz8i4a6h	137	17	as	as	IN
cord-006788-kz8i4a6h	137	18	shown	show	VBN
cord-006788-kz8i4a6h	137	19	in	in	IN
cord-006788-kz8i4a6h	137	20	mice	mouse	NNS
cord-006788-kz8i4a6h	137	21	[	[	-LRB-
cord-006788-kz8i4a6h	137	22	108	108	CD
cord-006788-kz8i4a6h	137	23	,	,	,
cord-006788-kz8i4a6h	137	24	109	109	CD
cord-006788-kz8i4a6h	137	25	]	]	-RRB-
cord-006788-kz8i4a6h	137	26	.	.	.
cord-006788-kz8i4a6h	138	1	In	in	IN
cord-006788-kz8i4a6h	138	2	cold	cold	JJ
cord-006788-kz8i4a6h	138	3	-	-	HYPH
cord-006788-kz8i4a6h	138	4	induced	induce	VBN
cord-006788-kz8i4a6h	138	5	nonshivering	nonshivere	VBG
cord-006788-kz8i4a6h	138	6	thermogenesis	thermogenesis	NN
cord-006788-kz8i4a6h	138	7	or	or	CC
cord-006788-kz8i4a6h	138	8	exercise	exercise	NN
cord-006788-kz8i4a6h	138	9	stress	stress	NN
cord-006788-kz8i4a6h	138	10	condition	condition	NN
cord-006788-kz8i4a6h	138	11	,	,	,
cord-006788-kz8i4a6h	138	12	BAT	BAT	NNP
cord-006788-kz8i4a6h	138	13	also	also	RB
cord-006788-kz8i4a6h	138	14	becomes	become	VBZ
cord-006788-kz8i4a6h	138	15	a	a	DT
cord-006788-kz8i4a6h	138	16	source	source	NN
cord-006788-kz8i4a6h	138	17	of	of	IN
cord-006788-kz8i4a6h	138	18	endocrine	endocrine	JJ
cord-006788-kz8i4a6h	138	19	FGF21	fgf21	NN
cord-006788-kz8i4a6h	138	20	in	in	IN
cord-006788-kz8i4a6h	138	21	a	a	DT
cord-006788-kz8i4a6h	138	22	β	β	NN
cord-006788-kz8i4a6h	138	23	-	-	HYPH
cord-006788-kz8i4a6h	138	24	adrenergicand	adrenergicand	NNP
cord-006788-kz8i4a6h	138	25	cAMPdependent	cAMPdependent	NNP
cord-006788-kz8i4a6h	138	26	manner	manner	NN
cord-006788-kz8i4a6h	138	27	,	,	,
cord-006788-kz8i4a6h	138	28	which	which	WDT
cord-006788-kz8i4a6h	138	29	in	in	IN
cord-006788-kz8i4a6h	138	30	turn	turn	NN
cord-006788-kz8i4a6h	138	31	facilitates	facilitate	VBZ
cord-006788-kz8i4a6h	138	32	mitochondrial	mitochondrial	JJ
cord-006788-kz8i4a6h	138	33	genesis	genesis	NN
cord-006788-kz8i4a6h	138	34	,	,	,
cord-006788-kz8i4a6h	138	35	oxidative	oxidative	JJ
cord-006788-kz8i4a6h	138	36	capacity	capacity	NN
cord-006788-kz8i4a6h	138	37	,	,	,
cord-006788-kz8i4a6h	138	38	uncoupling	uncoupling	NN
cord-006788-kz8i4a6h	138	39	,	,	,
cord-006788-kz8i4a6h	138	40	and	and	CC
cord-006788-kz8i4a6h	138	41	heat	heat	NN
cord-006788-kz8i4a6h	138	42	generation	generation	NN
cord-006788-kz8i4a6h	138	43	,	,	,
cord-006788-kz8i4a6h	138	44	leading	lead	VBG
cord-006788-kz8i4a6h	138	45	to	to	IN
cord-006788-kz8i4a6h	138	46	adaptation	adaptation	NN
cord-006788-kz8i4a6h	138	47	to	to	IN
cord-006788-kz8i4a6h	138	48	cold	cold	JJ
cord-006788-kz8i4a6h	138	49	conditions	condition	NNS
cord-006788-kz8i4a6h	138	50	and	and	CC
cord-006788-kz8i4a6h	138	51	core	core	NN
cord-006788-kz8i4a6h	138	52	body	body	NN
cord-006788-kz8i4a6h	138	53	temperature	temperature	NN
cord-006788-kz8i4a6h	138	54	maintenance	maintenance	NN
cord-006788-kz8i4a6h	138	55	[	[	-LRB-
cord-006788-kz8i4a6h	138	56	110	110	CD
cord-006788-kz8i4a6h	138	57	]	]	-RRB-
cord-006788-kz8i4a6h	138	58	[	[	-LRB-
cord-006788-kz8i4a6h	138	59	111	111	CD
cord-006788-kz8i4a6h	138	60	]	]	-RRB-
cord-006788-kz8i4a6h	138	61	[	[	-LRB-
cord-006788-kz8i4a6h	138	62	112	112	CD
cord-006788-kz8i4a6h	138	63	]	]	-RRB-
cord-006788-kz8i4a6h	138	64	.	.	.
cord-006788-kz8i4a6h	139	1	In	in	IN
cord-006788-kz8i4a6h	139	2	line	line	NN
cord-006788-kz8i4a6h	139	3	with	with	IN
cord-006788-kz8i4a6h	139	4	the	the	DT
cord-006788-kz8i4a6h	139	5	beneficial	beneficial	JJ
cord-006788-kz8i4a6h	139	6	effects	effect	NNS
cord-006788-kz8i4a6h	139	7	of	of	IN
cord-006788-kz8i4a6h	139	8	FGF21	fgf21	NN
cord-006788-kz8i4a6h	139	9	on	on	IN
cord-006788-kz8i4a6h	139	10	maintaining	maintain	VBG
cord-006788-kz8i4a6h	139	11	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	139	12	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	139	13	during	during	IN
cord-006788-kz8i4a6h	139	14	diverse	diverse	JJ
cord-006788-kz8i4a6h	139	15	adverse	adverse	JJ
cord-006788-kz8i4a6h	139	16	conditions	condition	NNS
cord-006788-kz8i4a6h	139	17	,	,	,
cord-006788-kz8i4a6h	139	18	pharmacological	pharmacological	JJ
cord-006788-kz8i4a6h	139	19	FGF21	FGF21	NNS
cord-006788-kz8i4a6h	139	20	markedly	markedly	RB
cord-006788-kz8i4a6h	139	21	extends	extend	VBZ
cord-006788-kz8i4a6h	139	22	the	the	DT
cord-006788-kz8i4a6h	139	23	lifespan	lifespan	NN
cord-006788-kz8i4a6h	139	24	of	of	IN
cord-006788-kz8i4a6h	139	25	mice	mouse	NNS
cord-006788-kz8i4a6h	139	26	by	by	IN
cord-006788-kz8i4a6h	139	27	blunting	blunt	VBG
cord-006788-kz8i4a6h	139	28	the	the	DT
cord-006788-kz8i4a6h	139	29	growth	growth	NN
cord-006788-kz8i4a6h	139	30	hormone	hormone	NN
cord-006788-kz8i4a6h	139	31	/	/	SYM
cord-006788-kz8i4a6h	139	32	insulinlike	insulinlike	JJ
cord-006788-kz8i4a6h	139	33	growth	growth	NN
cord-006788-kz8i4a6h	140	1	factor-1	factor-1	NNP
cord-006788-kz8i4a6h	141	1	signaling	signal	VBG
cord-006788-kz8i4a6h	141	2	pathway	pathway	NN
cord-006788-kz8i4a6h	141	3	in	in	IN
cord-006788-kz8i4a6h	141	4	the	the	DT
cord-006788-kz8i4a6h	141	5	liver	liver	NN
cord-006788-kz8i4a6h	141	6	without	without	IN
cord-006788-kz8i4a6h	141	7	reducing	reduce	VBG
cord-006788-kz8i4a6h	141	8	food	food	NN
cord-006788-kz8i4a6h	141	9	intake	intake	NN
cord-006788-kz8i4a6h	141	10	or	or	CC
cord-006788-kz8i4a6h	141	11	affecting	affect	VBG
cord-006788-kz8i4a6h	141	12	longevity	longevity	NN
cord-006788-kz8i4a6h	141	13	-	-	HYPH
cord-006788-kz8i4a6h	141	14	associated	associate	VBN
cord-006788-kz8i4a6h	141	15	markers	marker	NNS
cord-006788-kz8i4a6h	141	16	of	of	IN
cord-006788-kz8i4a6h	141	17	NAD	NAD	NNP
cord-006788-kz8i4a6h	141	18	+	+	CC
cord-006788-kz8i4a6h	141	19	metabolism	metabolism	NN
cord-006788-kz8i4a6h	141	20	,	,	,
cord-006788-kz8i4a6h	141	21	AMP	AMP	NNP
cord-006788-kz8i4a6h	141	22	kinase	kinase	NN
cord-006788-kz8i4a6h	141	23	,	,	,
cord-006788-kz8i4a6h	141	24	and	and	CC
cord-006788-kz8i4a6h	141	25	mTOR	mTOR	NNP
cord-006788-kz8i4a6h	141	26	signaling	signal	VBG
cord-006788-kz8i4a6h	141	27	pathways	pathway	NNS
cord-006788-kz8i4a6h	141	28	[	[	-LRB-
cord-006788-kz8i4a6h	141	29	113	113	CD
cord-006788-kz8i4a6h	141	30	]	]	-RRB-
cord-006788-kz8i4a6h	141	31	.	.	.
cord-006788-kz8i4a6h	142	1	The	the	DT
cord-006788-kz8i4a6h	142	2	thymus	thymus	NN
cord-006788-kz8i4a6h	142	3	functions	function	NNS
cord-006788-kz8i4a6h	142	4	in	in	IN
cord-006788-kz8i4a6h	142	5	producing	produce	VBG
cord-006788-kz8i4a6h	142	6	new	new	JJ
cord-006788-kz8i4a6h	142	7	T	t	NN
cord-006788-kz8i4a6h	142	8	cells	cell	NNS
cord-006788-kz8i4a6h	142	9	for	for	IN
cord-006788-kz8i4a6h	142	10	the	the	DT
cord-006788-kz8i4a6h	142	11	immune	immune	JJ
cord-006788-kz8i4a6h	142	12	system	system	NN
cord-006788-kz8i4a6h	142	13	,	,	,
cord-006788-kz8i4a6h	142	14	but	but	CC
cord-006788-kz8i4a6h	142	15	with	with	IN
cord-006788-kz8i4a6h	142	16	age	age	NN
cord-006788-kz8i4a6h	142	17	,	,	,
cord-006788-kz8i4a6h	142	18	it	-PRON-	PRP
cord-006788-kz8i4a6h	142	19	becomes	become	VBZ
cord-006788-kz8i4a6h	142	20	fatty	fatty	JJ
cord-006788-kz8i4a6h	142	21	and	and	CC
cord-006788-kz8i4a6h	142	22	loses	lose	VBZ
cord-006788-kz8i4a6h	142	23	the	the	DT
cord-006788-kz8i4a6h	142	24	ability	ability	NN
cord-006788-kz8i4a6h	142	25	to	to	TO
cord-006788-kz8i4a6h	142	26	produce	produce	VB
cord-006788-kz8i4a6h	142	27	a	a	DT
cord-006788-kz8i4a6h	142	28	sufficient	sufficient	JJ
cord-006788-kz8i4a6h	142	29	amount	amount	NN
cord-006788-kz8i4a6h	142	30	of	of	IN
cord-006788-kz8i4a6h	142	31	new	new	JJ
cord-006788-kz8i4a6h	142	32	T	T	NNP
cord-006788-kz8i4a6h	142	33	cells	cell	NNS
cord-006788-kz8i4a6h	142	34	,	,	,
cord-006788-kz8i4a6h	142	35	which	which	WDT
cord-006788-kz8i4a6h	142	36	is	be	VBZ
cord-006788-kz8i4a6h	142	37	an	an	DT
cord-006788-kz8i4a6h	142	38	important	important	JJ
cord-006788-kz8i4a6h	142	39	cause	cause	NN
cord-006788-kz8i4a6h	142	40	of	of	IN
cord-006788-kz8i4a6h	142	41	increased	increase	VBN
cord-006788-kz8i4a6h	142	42	risks	risk	NNS
cord-006788-kz8i4a6h	142	43	of	of	IN
cord-006788-kz8i4a6h	142	44	infections	infection	NNS
cord-006788-kz8i4a6h	142	45	,	,	,
cord-006788-kz8i4a6h	142	46	obesity	obesity	NN
cord-006788-kz8i4a6h	142	47	,	,	,
cord-006788-kz8i4a6h	142	48	diabetes	diabetes	NN
cord-006788-kz8i4a6h	142	49	,	,	,
cord-006788-kz8i4a6h	142	50	and	and	CC
cord-006788-kz8i4a6h	142	51	certain	certain	JJ
cord-006788-kz8i4a6h	142	52	cancer	cancer	NN
cord-006788-kz8i4a6h	142	53	types	type	NNS
cord-006788-kz8i4a6h	142	54	,	,	,
cord-006788-kz8i4a6h	142	55	leading	lead	VBG
cord-006788-kz8i4a6h	142	56	to	to	IN
cord-006788-kz8i4a6h	142	57	reduced	reduce	VBN
cord-006788-kz8i4a6h	142	58	lifespan	lifespan	NN
cord-006788-kz8i4a6h	142	59	in	in	IN
cord-006788-kz8i4a6h	142	60	the	the	DT
cord-006788-kz8i4a6h	142	61	elderly	elderly	JJ
cord-006788-kz8i4a6h	142	62	people	people	NNS
cord-006788-kz8i4a6h	142	63	.	.	.
cord-006788-kz8i4a6h	143	1	The	the	DT
cord-006788-kz8i4a6h	143	2	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	143	3	level	level	NN
cord-006788-kz8i4a6h	143	4	in	in	IN
cord-006788-kz8i4a6h	143	5	thymic	thymic	JJ
cord-006788-kz8i4a6h	143	6	epithelial	epithelial	JJ
cord-006788-kz8i4a6h	143	7	cells	cell	NNS
cord-006788-kz8i4a6h	143	8	is	be	VBZ
cord-006788-kz8i4a6h	143	9	several	several	JJ
cord-006788-kz8i4a6h	143	10	folds	fold	NNS
cord-006788-kz8i4a6h	143	11	higher	high	JJR
cord-006788-kz8i4a6h	143	12	than	than	IN
cord-006788-kz8i4a6h	143	13	that	that	DT
cord-006788-kz8i4a6h	143	14	in	in	IN
cord-006788-kz8i4a6h	143	15	the	the	DT
cord-006788-kz8i4a6h	143	16	liver	liver	NN
cord-006788-kz8i4a6h	143	17	.	.	.
cord-006788-kz8i4a6h	144	1	The	the	DT
cord-006788-kz8i4a6h	144	2	high	high	JJ
cord-006788-kz8i4a6h	144	3	level	level	NN
cord-006788-kz8i4a6h	144	4	of	of	IN
cord-006788-kz8i4a6h	144	5	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	144	6	is	be	VBZ
cord-006788-kz8i4a6h	144	7	proposed	propose	VBN
cord-006788-kz8i4a6h	144	8	to	to	TO
cord-006788-kz8i4a6h	144	9	protect	protect	VB
cord-006788-kz8i4a6h	144	10	thymus	thymus	NN
cord-006788-kz8i4a6h	144	11	from	from	IN
cord-006788-kz8i4a6h	144	12	the	the	DT
cord-006788-kz8i4a6h	144	13	agerelated	agerelate	VBN
cord-006788-kz8i4a6h	144	14	fatty	fatty	JJ
cord-006788-kz8i4a6h	144	15	degeneration	degeneration	NN
cord-006788-kz8i4a6h	144	16	and	and	CC
cord-006788-kz8i4a6h	144	17	to	to	TO
cord-006788-kz8i4a6h	144	18	increase	increase	VB
cord-006788-kz8i4a6h	144	19	the	the	DT
cord-006788-kz8i4a6h	144	20	production	production	NN
cord-006788-kz8i4a6h	144	21	of	of	IN
cord-006788-kz8i4a6h	144	22	new	new	JJ
cord-006788-kz8i4a6h	144	23	T	T	NNP
cord-006788-kz8i4a6h	144	24	cells	cell	NNS
cord-006788-kz8i4a6h	144	25	to	to	TO
cord-006788-kz8i4a6h	144	26	bolster	bolster	VB
cord-006788-kz8i4a6h	144	27	immune	immune	JJ
cord-006788-kz8i4a6h	144	28	function	function	NN
cord-006788-kz8i4a6h	144	29	,	,	,
cord-006788-kz8i4a6h	144	30	thereby	thereby	RB
cord-006788-kz8i4a6h	144	31	lowering	lower	VBG
cord-006788-kz8i4a6h	144	32	the	the	DT
cord-006788-kz8i4a6h	144	33	incidence	incidence	NN
cord-006788-kz8i4a6h	144	34	of	of	IN
cord-006788-kz8i4a6h	144	35	diseases	disease	NNS
cord-006788-kz8i4a6h	144	36	and	and	CC
cord-006788-kz8i4a6h	144	37	promoting	promote	VBG
cord-006788-kz8i4a6h	144	38	longevity	longevity	NN
cord-006788-kz8i4a6h	144	39	[	[	-LRB-
cord-006788-kz8i4a6h	144	40	114	114	CD
cord-006788-kz8i4a6h	144	41	]	]	-RRB-
cord-006788-kz8i4a6h	144	42	.	.	.
cord-006788-kz8i4a6h	145	1	The	the	DT
cord-006788-kz8i4a6h	145	2	acinar	acinar	JJ
cord-006788-kz8i4a6h	145	3	cell	cell	NN
cord-006788-kz8i4a6h	145	4	compartment	compartment	NN
cord-006788-kz8i4a6h	145	5	in	in	IN
cord-006788-kz8i4a6h	145	6	the	the	DT
cord-006788-kz8i4a6h	145	7	pancreas	pancreas	NN
cord-006788-kz8i4a6h	145	8	expresses	express	VBZ
cord-006788-kz8i4a6h	145	9	the	the	DT
cord-006788-kz8i4a6h	145	10	highest	high	JJS
cord-006788-kz8i4a6h	145	11	levels	level	NNS
cord-006788-kz8i4a6h	145	12	of	of	IN
cord-006788-kz8i4a6h	145	13	FGF21	fgf21	NN
cord-006788-kz8i4a6h	145	14	constitutively	constitutively	RB
cord-006788-kz8i4a6h	145	15	among	among	IN
cord-006788-kz8i4a6h	145	16	tissues	tissue	NNS
cord-006788-kz8i4a6h	145	17	,	,	,
cord-006788-kz8i4a6h	145	18	but	but	CC
cord-006788-kz8i4a6h	145	19	contributes	contribute	VBZ
cord-006788-kz8i4a6h	145	20	little	little	JJ
cord-006788-kz8i4a6h	145	21	to	to	IN
cord-006788-kz8i4a6h	145	22	the	the	DT
cord-006788-kz8i4a6h	145	23	circulation	circulation	NN
cord-006788-kz8i4a6h	145	24	[	[	-LRB-
cord-006788-kz8i4a6h	145	25	56	56	CD
cord-006788-kz8i4a6h	145	26	,	,	,
cord-006788-kz8i4a6h	145	27	115	115	CD
cord-006788-kz8i4a6h	145	28	]	]	-RRB-
cord-006788-kz8i4a6h	145	29	.	.	.
cord-006788-kz8i4a6h	146	1	Acinar	Acinar	NNP
cord-006788-kz8i4a6h	146	2	cells	cell	NNS
cord-006788-kz8i4a6h	146	3	appear	appear	VBP
cord-006788-kz8i4a6h	146	4	to	to	TO
cord-006788-kz8i4a6h	146	5	be	be	VB
cord-006788-kz8i4a6h	146	6	both	both	CC
cord-006788-kz8i4a6h	146	7	the	the	DT
cord-006788-kz8i4a6h	146	8	dominant	dominant	JJ
cord-006788-kz8i4a6h	146	9	source	source	NN
cord-006788-kz8i4a6h	146	10	and	and	CC
cord-006788-kz8i4a6h	146	11	target	target	NN
cord-006788-kz8i4a6h	146	12	(	(	-LRB-
cord-006788-kz8i4a6h	146	13	via	via	IN
cord-006788-kz8i4a6h	146	14	FGFR1-KLB	FGFR1-KLB	NNP
cord-006788-kz8i4a6h	146	15	complex	complex	NNP
cord-006788-kz8i4a6h	146	16	)	)	-RRB-
cord-006788-kz8i4a6h	146	17	of	of	IN
cord-006788-kz8i4a6h	146	18	pancreatic	pancreatic	JJ
cord-006788-kz8i4a6h	146	19	FGF21	fgf21	NN
cord-006788-kz8i4a6h	146	20	.	.	.
cord-006788-kz8i4a6h	147	1	The	the	DT
cord-006788-kz8i4a6h	147	2	high	high	JJ
cord-006788-kz8i4a6h	147	3	levels	level	NNS
cord-006788-kz8i4a6h	147	4	of	of	IN
cord-006788-kz8i4a6h	147	5	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	147	6	is	be	VBZ
cord-006788-kz8i4a6h	147	7	proposed	propose	VBN
cord-006788-kz8i4a6h	147	8	to	to	TO
cord-006788-kz8i4a6h	147	9	act	act	VB
cord-006788-kz8i4a6h	147	10	as	as	IN
cord-006788-kz8i4a6h	147	11	an	an	DT
cord-006788-kz8i4a6h	147	12	exocrine	exocrine	JJ
cord-006788-kz8i4a6h	147	13	pancreas	pancreas	NN
cord-006788-kz8i4a6h	147	14	secretagogue	secretagogue	NN
cord-006788-kz8i4a6h	147	15	to	to	TO
cord-006788-kz8i4a6h	147	16	stimulate	stimulate	VB
cord-006788-kz8i4a6h	147	17	pancreatic	pancreatic	JJ
cord-006788-kz8i4a6h	147	18	digestive	digestive	JJ
cord-006788-kz8i4a6h	147	19	enzyme	enzyme	NN
cord-006788-kz8i4a6h	147	20	secretion	secretion	NN
cord-006788-kz8i4a6h	147	21	and	and	CC
cord-006788-kz8i4a6h	147	22	pancreatic	pancreatic	JJ
cord-006788-kz8i4a6h	147	23	juice	juice	NN
cord-006788-kz8i4a6h	147	24	flow	flow	NN
cord-006788-kz8i4a6h	147	25	to	to	IN
cord-006788-kz8i4a6h	147	26	the	the	DT
cord-006788-kz8i4a6h	147	27	intestine	intestine	NN
cord-006788-kz8i4a6h	147	28	,	,	,
cord-006788-kz8i4a6h	147	29	thereby	thereby	RB
cord-006788-kz8i4a6h	147	30	relieving	relieve	VBG
cord-006788-kz8i4a6h	147	31	potential	potential	JJ
cord-006788-kz8i4a6h	147	32	self	self	NN
cord-006788-kz8i4a6h	147	33	-	-	HYPH
cord-006788-kz8i4a6h	147	34	digestion	digestion	NN
cord-006788-kz8i4a6h	147	35	caused	cause	VBN
cord-006788-kz8i4a6h	147	36	proteostasis	proteostasis	NN
cord-006788-kz8i4a6h	147	37	stress	stress	NN
cord-006788-kz8i4a6h	147	38	and	and	CC
cord-006788-kz8i4a6h	147	39	protecting	protect	VBG
cord-006788-kz8i4a6h	147	40	pancreas	pancrea	NNS
cord-006788-kz8i4a6h	147	41	from	from	IN
cord-006788-kz8i4a6h	147	42	pancreatitis	pancreatitis	NN
cord-006788-kz8i4a6h	147	43	,	,	,
cord-006788-kz8i4a6h	147	44	including	include	VBG
cord-006788-kz8i4a6h	147	45	but	but	CC
cord-006788-kz8i4a6h	147	46	not	not	RB
cord-006788-kz8i4a6h	147	47	limited	limited	JJ
cord-006788-kz8i4a6h	147	48	to	to	IN
cord-006788-kz8i4a6h	147	49	those	those	DT
cord-006788-kz8i4a6h	147	50	caused	cause	VBN
cord-006788-kz8i4a6h	147	51	by	by	IN
cord-006788-kz8i4a6h	147	52	high	high	JJ
cord-006788-kz8i4a6h	147	53	-	-	HYPH
cord-006788-kz8i4a6h	147	54	fat	fat	NN
cord-006788-kz8i4a6h	147	55	diet	diet	NN
cord-006788-kz8i4a6h	147	56	,	,	,
cord-006788-kz8i4a6h	147	57	pancreatic	pancreatic	JJ
cord-006788-kz8i4a6h	147	58	toxins	toxin	NNS
cord-006788-kz8i4a6h	147	59	,	,	,
cord-006788-kz8i4a6h	147	60	and	and	CC
cord-006788-kz8i4a6h	147	61	alcoholism	alcoholism	NN
cord-006788-kz8i4a6h	147	62	[	[	-LRB-
cord-006788-kz8i4a6h	147	63	116	116	CD
cord-006788-kz8i4a6h	147	64	]	]	-RRB-
cord-006788-kz8i4a6h	147	65	.	.	.
cord-006788-kz8i4a6h	148	1	Although	although	IN
cord-006788-kz8i4a6h	148	2	islets	islet	NNS
cord-006788-kz8i4a6h	148	3	express	express	VBP
cord-006788-kz8i4a6h	148	4	significantly	significantly	RB
cord-006788-kz8i4a6h	148	5	lower	low	JJR
cord-006788-kz8i4a6h	148	6	amounts	amount	NNS
cord-006788-kz8i4a6h	148	7	of	of	IN
cord-006788-kz8i4a6h	148	8	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	148	9	,	,	,
cord-006788-kz8i4a6h	148	10	acinar	acinar	JJ
cord-006788-kz8i4a6h	148	11	cell	cell	NN
cord-006788-kz8i4a6h	148	12	derived	derive	VBN
cord-006788-kz8i4a6h	148	13	or	or	CC
cord-006788-kz8i4a6h	148	14	endocrine	endocrine	JJ
cord-006788-kz8i4a6h	149	1	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	149	2	helps	help	VBZ
cord-006788-kz8i4a6h	149	3	protect	protect	VB
cord-006788-kz8i4a6h	149	4	against	against	IN
cord-006788-kz8i4a6h	149	5	fatty	fatty	JJ
cord-006788-kz8i4a6h	149	6	pancreas	pancrea	NNS
cord-006788-kz8i4a6h	149	7	,	,	,
cord-006788-kz8i4a6h	149	8	high	high	JJ
cord-006788-kz8i4a6h	149	9	-	-	HYPH
cord-006788-kz8i4a6h	149	10	fat	fat	NN
cord-006788-kz8i4a6h	149	11	diet	diet	NN
cord-006788-kz8i4a6h	149	12	induced	induce	VBN
cord-006788-kz8i4a6h	149	13	islet	islet	NN
cord-006788-kz8i4a6h	149	14	hyperplasia	hyperplasia	NN
cord-006788-kz8i4a6h	149	15	,	,	,
cord-006788-kz8i4a6h	149	16	and	and	CC
cord-006788-kz8i4a6h	149	17	inflammatory	inflammatory	JJ
cord-006788-kz8i4a6h	149	18	damage	damage	NN
cord-006788-kz8i4a6h	149	19	[	[	-LRB-
cord-006788-kz8i4a6h	149	20	117	117	CD
cord-006788-kz8i4a6h	149	21	]	]	-RRB-
cord-006788-kz8i4a6h	150	1	[	[	-LRB-
cord-006788-kz8i4a6h	150	2	118	118	CD
cord-006788-kz8i4a6h	150	3	]	]	-RRB-
cord-006788-kz8i4a6h	150	4	[	[	-LRB-
cord-006788-kz8i4a6h	150	5	119	119	CD
cord-006788-kz8i4a6h	150	6	]	]	-RRB-
cord-006788-kz8i4a6h	150	7	.	.	.
cord-006788-kz8i4a6h	151	1	Demyelination	Demyelination	NNP
cord-006788-kz8i4a6h	151	2	in	in	IN
cord-006788-kz8i4a6h	151	3	the	the	DT
cord-006788-kz8i4a6h	151	4	CNS	CNS	NNP
cord-006788-kz8i4a6h	151	5	can	can	MD
cord-006788-kz8i4a6h	151	6	cause	cause	VB
cord-006788-kz8i4a6h	151	7	severe	severe	JJ
cord-006788-kz8i4a6h	151	8	neurological	neurological	JJ
cord-006788-kz8i4a6h	151	9	deficits	deficit	NNS
cord-006788-kz8i4a6h	151	10	,	,	,
cord-006788-kz8i4a6h	151	11	such	such	JJ
cord-006788-kz8i4a6h	151	12	as	as	IN
cord-006788-kz8i4a6h	151	13	multiple	multiple	JJ
cord-006788-kz8i4a6h	151	14	sclerosis	sclerosis	NN
cord-006788-kz8i4a6h	151	15	and	and	CC
cord-006788-kz8i4a6h	151	16	neurological	neurological	JJ
cord-006788-kz8i4a6h	151	17	dysfunction	dysfunction	NN
cord-006788-kz8i4a6h	151	18	.	.	.
cord-006788-kz8i4a6h	152	1	Pancreatic	pancreatic	JJ
cord-006788-kz8i4a6h	152	2	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	152	3	acts	act	NNS
cord-006788-kz8i4a6h	152	4	on	on	IN
cord-006788-kz8i4a6h	152	5	oligodendrocyte	oligodendrocyte	NNP
cord-006788-kz8i4a6h	152	6	precursor	precursor	NN
cord-006788-kz8i4a6h	152	7	cells	cell	NNS
cord-006788-kz8i4a6h	152	8	to	to	TO
cord-006788-kz8i4a6h	152	9	promote	promote	VB
cord-006788-kz8i4a6h	152	10	the	the	DT
cord-006788-kz8i4a6h	152	11	remyelination	remyelination	NN
cord-006788-kz8i4a6h	152	12	process	process	NN
cord-006788-kz8i4a6h	152	13	,	,	,
cord-006788-kz8i4a6h	152	14	leading	lead	VBG
cord-006788-kz8i4a6h	152	15	to	to	IN
cord-006788-kz8i4a6h	152	16	better	well	JJR
cord-006788-kz8i4a6h	152	17	recovery	recovery	NN
cord-006788-kz8i4a6h	152	18	of	of	IN
cord-006788-kz8i4a6h	152	19	neurological	neurological	JJ
cord-006788-kz8i4a6h	152	20	functions	function	NNS
cord-006788-kz8i4a6h	152	21	in	in	IN
cord-006788-kz8i4a6h	152	22	mice	mouse	NNS
cord-006788-kz8i4a6h	152	23	[	[	-LRB-
cord-006788-kz8i4a6h	152	24	120	120	CD
cord-006788-kz8i4a6h	152	25	]	]	-RRB-
cord-006788-kz8i4a6h	152	26	.	.	.
cord-006788-kz8i4a6h	153	1	The	the	DT
cord-006788-kz8i4a6h	153	2	liver	liver	NN
cord-006788-kz8i4a6h	153	3	is	be	VBZ
cord-006788-kz8i4a6h	153	4	the	the	DT
cord-006788-kz8i4a6h	153	5	major	major	JJ
cord-006788-kz8i4a6h	153	6	organ	organ	NN
cord-006788-kz8i4a6h	153	7	of	of	IN
cord-006788-kz8i4a6h	153	8	origin	origin	NN
cord-006788-kz8i4a6h	153	9	of	of	IN
cord-006788-kz8i4a6h	153	10	endocrine	endocrine	JJ
cord-006788-kz8i4a6h	153	11	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	153	12	in	in	IN
cord-006788-kz8i4a6h	153	13	response	response	NN
cord-006788-kz8i4a6h	153	14	to	to	IN
cord-006788-kz8i4a6h	153	15	a	a	DT
cord-006788-kz8i4a6h	153	16	broad	broad	JJ
cord-006788-kz8i4a6h	153	17	spectrum	spectrum	NN
cord-006788-kz8i4a6h	153	18	of	of	IN
cord-006788-kz8i4a6h	153	19	stress	stress	NN
cord-006788-kz8i4a6h	153	20	conditions	condition	NNS
cord-006788-kz8i4a6h	153	21	.	.	.
cord-006788-kz8i4a6h	154	1	The	the	DT
cord-006788-kz8i4a6h	154	2	hepatic	hepatic	JJ
cord-006788-kz8i4a6h	154	3	and	and	CC
cord-006788-kz8i4a6h	154	4	pharmacological	pharmacological	JJ
cord-006788-kz8i4a6h	154	5	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	154	6	drive	drive	VBP
cord-006788-kz8i4a6h	154	7	multiple	multiple	JJ
cord-006788-kz8i4a6h	154	8	signal	signal	NN
cord-006788-kz8i4a6h	154	9	axes	axis	NNS
cord-006788-kz8i4a6h	154	10	in	in	IN
cord-006788-kz8i4a6h	154	11	multiple	multiple	JJ
cord-006788-kz8i4a6h	154	12	tissues	tissue	NNS
cord-006788-kz8i4a6h	154	13	/	/	SYM
cord-006788-kz8i4a6h	154	14	organs	organ	NNS
cord-006788-kz8i4a6h	154	15	,	,	,
cord-006788-kz8i4a6h	154	16	resulting	result	VBG
cord-006788-kz8i4a6h	154	17	in	in	IN
cord-006788-kz8i4a6h	154	18	multifaceted	multifaceted	JJ
cord-006788-kz8i4a6h	154	19	beneficiary	beneficiary	NN
cord-006788-kz8i4a6h	154	20	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	154	21	effects	effect	NNS
cord-006788-kz8i4a6h	154	22	,	,	,
cord-006788-kz8i4a6h	154	23	including	include	VBG
cord-006788-kz8i4a6h	154	24	promoting	promote	VBG
cord-006788-kz8i4a6h	154	25	(	(	-LRB-
cord-006788-kz8i4a6h	154	26	green	green	JJ
cord-006788-kz8i4a6h	154	27	arrow	arrow	NN
cord-006788-kz8i4a6h	154	28	)	)	-RRB-
cord-006788-kz8i4a6h	154	29	glucose	glucose	NN
cord-006788-kz8i4a6h	154	30	,	,	,
cord-006788-kz8i4a6h	154	31	lipid	lipid	NN
cord-006788-kz8i4a6h	154	32	,	,	,
cord-006788-kz8i4a6h	154	33	and	and	CC
cord-006788-kz8i4a6h	154	34	energy	energy	NN
cord-006788-kz8i4a6h	154	35	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	154	36	;	;	:
cord-006788-kz8i4a6h	154	37	offsetting	offset	VBG
cord-006788-kz8i4a6h	154	38	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	154	39	derangements	derangement	NNS
cord-006788-kz8i4a6h	154	40	;	;	:
cord-006788-kz8i4a6h	154	41	and	and	CC
cord-006788-kz8i4a6h	154	42	preventing	prevent	VBG
cord-006788-kz8i4a6h	154	43	(	(	-LRB-
cord-006788-kz8i4a6h	154	44	red	red	JJ
cord-006788-kz8i4a6h	154	45	long	long	JJ
cord-006788-kz8i4a6h	154	46	-	-	HYPH
cord-006788-kz8i4a6h	154	47	tailed	tailed	JJ
cord-006788-kz8i4a6h	154	48	"	"	``
cord-006788-kz8i4a6h	154	49	T	t	NN
cord-006788-kz8i4a6h	154	50	"	"	''
cord-006788-kz8i4a6h	154	51	sign	sign	NN
cord-006788-kz8i4a6h	154	52	)	)	-RRB-
cord-006788-kz8i4a6h	154	53	metaflammation	metaflammation	NN
cord-006788-kz8i4a6h	154	54	,	,	,
cord-006788-kz8i4a6h	154	55	inflammatory	inflammatory	JJ
cord-006788-kz8i4a6h	154	56	tissue	tissue	NN
cord-006788-kz8i4a6h	154	57	damage	damage	NN
cord-006788-kz8i4a6h	154	58	,	,	,
cord-006788-kz8i4a6h	154	59	and	and	CC
cord-006788-kz8i4a6h	154	60	tissue	tissue	NN
cord-006788-kz8i4a6h	154	61	-	-	HYPH
cord-006788-kz8i4a6h	154	62	specific	specific	JJ
cord-006788-kz8i4a6h	154	63	pathogenesis	pathogenesis	NN
cord-006788-kz8i4a6h	154	64	,	,	,
cord-006788-kz8i4a6h	154	65	including	include	VBG
cord-006788-kz8i4a6h	154	66	obesity	obesity	NN
cord-006788-kz8i4a6h	154	67	,	,	,
cord-006788-kz8i4a6h	154	68	type	type	NN
cord-006788-kz8i4a6h	154	69	2	2	CD
cord-006788-kz8i4a6h	154	70	diabetes	diabetes	NN
cord-006788-kz8i4a6h	154	71	,	,	,
cord-006788-kz8i4a6h	154	72	fatty	fatty	JJ
cord-006788-kz8i4a6h	154	73	liver	liver	NN
cord-006788-kz8i4a6h	154	74	disease	disease	NN
cord-006788-kz8i4a6h	154	75	,	,	,
cord-006788-kz8i4a6h	154	76	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	154	77	syndrome	syndrome	NN
cord-006788-kz8i4a6h	154	78	,	,	,
cord-006788-kz8i4a6h	154	79	and	and	CC
cord-006788-kz8i4a6h	154	80	associated	associated	JJ
cord-006788-kz8i4a6h	154	81	comorbidities	comorbiditie	NNS
cord-006788-kz8i4a6h	154	82	.	.	.
cord-006788-kz8i4a6h	155	1	FAA	FAA	NNP
cord-006788-kz8i4a6h	155	2	:	:	:
cord-006788-kz8i4a6h	155	3	free	free	JJ
cord-006788-kz8i4a6h	155	4	fatty	fatty	JJ
cord-006788-kz8i4a6h	155	5	acids	acid	NNS
cord-006788-kz8i4a6h	155	6	.	.	.
cord-006788-kz8i4a6h	156	1	Black	black	JJ
cord-006788-kz8i4a6h	156	2	semicircular	semicircular	JJ
cord-006788-kz8i4a6h	156	3	arrows	arrow	NNS
cord-006788-kz8i4a6h	156	4	indicate	indicate	VBP
cord-006788-kz8i4a6h	156	5	possibility	possibility	NN
cord-006788-kz8i4a6h	156	6	of	of	IN
cord-006788-kz8i4a6h	156	7	paracrine	paracrine	JJ
cord-006788-kz8i4a6h	156	8	mode	mode	NN
cord-006788-kz8i4a6h	156	9	of	of	IN
cord-006788-kz8i4a6h	156	10	FGF21	fgf21	NN
cord-006788-kz8i4a6h	156	11	within	within	IN
cord-006788-kz8i4a6h	156	12	local	local	JJ
cord-006788-kz8i4a6h	156	13	tissue	tissue	NN
cord-006788-kz8i4a6h	156	14	environment	environment	NN
cord-006788-kz8i4a6h	156	15	.	.	.
cord-006788-kz8i4a6h	157	1	Exposure	exposure	NN
cord-006788-kz8i4a6h	157	2	to	to	IN
cord-006788-kz8i4a6h	157	3	alcohol	alcohol	NN
cord-006788-kz8i4a6h	157	4	or	or	CC
cord-006788-kz8i4a6h	157	5	sugar	sugar	NN
cord-006788-kz8i4a6h	157	6	induces	induce	VBZ
cord-006788-kz8i4a6h	157	7	hepatic	hepatic	JJ
cord-006788-kz8i4a6h	157	8	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	157	9	through	through	IN
cord-006788-kz8i4a6h	157	10	ChREBP	ChREBP	NNP
cord-006788-kz8i4a6h	157	11	,	,	,
cord-006788-kz8i4a6h	157	12	which	which	WDT
cord-006788-kz8i4a6h	157	13	then	then	RB
cord-006788-kz8i4a6h	157	14	acts	act	VBZ
cord-006788-kz8i4a6h	157	15	on	on	IN
cord-006788-kz8i4a6h	157	16	the	the	DT
cord-006788-kz8i4a6h	157	17	hypothalamus	hypothalamus	NN
cord-006788-kz8i4a6h	157	18	reward	reward	NN
cord-006788-kz8i4a6h	157	19	pathway	pathway	NN
cord-006788-kz8i4a6h	157	20	to	to	TO
cord-006788-kz8i4a6h	157	21	suppress	suppress	VB
cord-006788-kz8i4a6h	157	22	the	the	DT
cord-006788-kz8i4a6h	157	23	desire	desire	NN
cord-006788-kz8i4a6h	157	24	for	for	IN
cord-006788-kz8i4a6h	157	25	sugar	sugar	NN
cord-006788-kz8i4a6h	157	26	and	and	CC
cord-006788-kz8i4a6h	157	27	alcohol	alcohol	NN
cord-006788-kz8i4a6h	157	28	in	in	IN
cord-006788-kz8i4a6h	157	29	favor	favor	NN
cord-006788-kz8i4a6h	157	30	of	of	IN
cord-006788-kz8i4a6h	157	31	drinking	drink	VBG
cord-006788-kz8i4a6h	157	32	water	water	NN
cord-006788-kz8i4a6h	157	33	in	in	IN
cord-006788-kz8i4a6h	157	34	mice	mouse	NNS
cord-006788-kz8i4a6h	157	35	depending	depend	VBG
cord-006788-kz8i4a6h	157	36	on	on	IN
cord-006788-kz8i4a6h	157	37	the	the	DT
cord-006788-kz8i4a6h	157	38	β	β	NN
cord-006788-kz8i4a6h	157	39	-	-	HYPH
cord-006788-kz8i4a6h	157	40	adrenergic	adrenergic	NN
cord-006788-kz8i4a6h	157	41	circuit	circuit	NN
cord-006788-kz8i4a6h	157	42	[	[	-LRB-
cord-006788-kz8i4a6h	157	43	97	97	CD
cord-006788-kz8i4a6h	157	44	,	,	,
cord-006788-kz8i4a6h	157	45	98	98	CD
cord-006788-kz8i4a6h	157	46	,	,	,
cord-006788-kz8i4a6h	157	47	121	121	CD
cord-006788-kz8i4a6h	157	48	,	,	,
cord-006788-kz8i4a6h	157	49	122	122	CD
cord-006788-kz8i4a6h	157	50	]	]	-RRB-
cord-006788-kz8i4a6h	157	51	.	.	.
cord-006788-kz8i4a6h	158	1	This	this	DT
cord-006788-kz8i4a6h	158	2	finding	finding	NN
cord-006788-kz8i4a6h	158	3	may	may	MD
cord-006788-kz8i4a6h	158	4	represent	represent	VB
cord-006788-kz8i4a6h	158	5	a	a	DT
cord-006788-kz8i4a6h	158	6	new	new	JJ
cord-006788-kz8i4a6h	158	7	hydration	hydration	NN
cord-006788-kz8i4a6h	158	8	pathway	pathway	NN
cord-006788-kz8i4a6h	158	9	that	that	WDT
cord-006788-kz8i4a6h	158	10	is	be	VBZ
cord-006788-kz8i4a6h	158	11	independent	independent	JJ
cord-006788-kz8i4a6h	158	12	of	of	IN
cord-006788-kz8i4a6h	158	13	the	the	DT
cord-006788-kz8i4a6h	158	14	classical	classical	JJ
cord-006788-kz8i4a6h	158	15	renin	renin	NN
cord-006788-kz8i4a6h	158	16	-	-	HYPH
cord-006788-kz8i4a6h	158	17	angiotensin	angiotensin	NN
cord-006788-kz8i4a6h	158	18	-	-	HYPH
cord-006788-kz8i4a6h	158	19	aldosterone	aldosterone	NN
cord-006788-kz8i4a6h	158	20	thirsty	thirsty	JJ
cord-006788-kz8i4a6h	158	21	pathway	pathway	NN
cord-006788-kz8i4a6h	158	22	in	in	IN
cord-006788-kz8i4a6h	158	23	the	the	DT
cord-006788-kz8i4a6h	158	24	kidney	kidney	NN
cord-006788-kz8i4a6h	158	25	in	in	IN
cord-006788-kz8i4a6h	158	26	response	response	NN
cord-006788-kz8i4a6h	158	27	to	to	IN
cord-006788-kz8i4a6h	158	28	nutritional	nutritional	JJ
cord-006788-kz8i4a6h	158	29	stress	stress	NN
cord-006788-kz8i4a6h	158	30	,	,	,
cord-006788-kz8i4a6h	158	31	suggesting	suggest	VBG
cord-006788-kz8i4a6h	158	32	a	a	DT
cord-006788-kz8i4a6h	158	33	previously	previously	RB
cord-006788-kz8i4a6h	158	34	underappreciated	underappreciated	JJ
cord-006788-kz8i4a6h	158	35	association	association	NN
cord-006788-kz8i4a6h	158	36	of	of	IN
cord-006788-kz8i4a6h	158	37	water	water	NN
cord-006788-kz8i4a6h	158	38	intake	intake	NN
cord-006788-kz8i4a6h	158	39	to	to	IN
cord-006788-kz8i4a6h	158	40	metabolism	metabolism	VB
cord-006788-kz8i4a6h	158	41	through	through	IN
cord-006788-kz8i4a6h	158	42	the	the	DT
cord-006788-kz8i4a6h	158	43	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	158	44	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	158	45	axis	axis	NN
cord-006788-kz8i4a6h	158	46	.	.	.
cord-006788-kz8i4a6h	159	1	A	a	DT
cord-006788-kz8i4a6h	159	2	human	human	JJ
cord-006788-kz8i4a6h	159	3	rs838133	rs838133	NNP
cord-006788-kz8i4a6h	159	4	allele	allele	NN
cord-006788-kz8i4a6h	159	5	in	in	IN
cord-006788-kz8i4a6h	159	6	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	159	7	is	be	VBZ
cord-006788-kz8i4a6h	159	8	associated	associate	VBN
cord-006788-kz8i4a6h	159	9	with	with	IN
cord-006788-kz8i4a6h	159	10	higher	high	JJR
cord-006788-kz8i4a6h	159	11	alcohol	alcohol	NN
cord-006788-kz8i4a6h	159	12	and	and	CC
cord-006788-kz8i4a6h	159	13	sugar	sugar	NN
cord-006788-kz8i4a6h	159	14	intake	intake	NN
cord-006788-kz8i4a6h	159	15	and	and	CC
cord-006788-kz8i4a6h	159	16	higher	high	JJR
cord-006788-kz8i4a6h	159	17	blood	blood	NN
cord-006788-kz8i4a6h	159	18	pressure	pressure	NN
cord-006788-kz8i4a6h	159	19	and	and	CC
cord-006788-kz8i4a6h	159	20	waist	waist	JJ
cord-006788-kz8i4a6h	159	21	-	-	HYPH
cord-006788-kz8i4a6h	159	22	hip	hip	NN
cord-006788-kz8i4a6h	159	23	ratio	ratio	NN
cord-006788-kz8i4a6h	159	24	,	,	,
cord-006788-kz8i4a6h	159	25	with	with	IN
cord-006788-kz8i4a6h	159	26	lower	low	JJR
cord-006788-kz8i4a6h	159	27	total	total	JJ
cord-006788-kz8i4a6h	159	28	body	body	NN
cord-006788-kz8i4a6h	159	29	-	-	HYPH
cord-006788-kz8i4a6h	159	30	fat	fat	NN
cord-006788-kz8i4a6h	159	31	percentage	percentage	NN
cord-006788-kz8i4a6h	159	32	[	[	-LRB-
cord-006788-kz8i4a6h	159	33	123	123	CD
cord-006788-kz8i4a6h	159	34	]	]	-RRB-
cord-006788-kz8i4a6h	159	35	.	.	.
cord-006788-kz8i4a6h	160	1	Comparison	comparison	NN
cord-006788-kz8i4a6h	160	2	of	of	IN
cord-006788-kz8i4a6h	160	3	the	the	DT
cord-006788-kz8i4a6h	160	4	genomes	genome	NNS
cord-006788-kz8i4a6h	160	5	of	of	IN
cord-006788-kz8i4a6h	160	6	more	more	JJR
cord-006788-kz8i4a6h	160	7	than	than	IN
cord-006788-kz8i4a6h	160	8	105	105	CD
cord-006788-kz8i4a6h	160	9	000	000	CD
cord-006788-kz8i4a6h	160	10	light	light	NN
cord-006788-kz8i4a6h	160	11	and	and	CC
cord-006788-kz8i4a6h	160	12	heavy	heavy	JJ
cord-006788-kz8i4a6h	160	13	social	social	JJ
cord-006788-kz8i4a6h	160	14	drinkers	drinker	NNS
cord-006788-kz8i4a6h	160	15	also	also	RB
cord-006788-kz8i4a6h	160	16	identifies	identify	VBZ
cord-006788-kz8i4a6h	160	17	a	a	DT
cord-006788-kz8i4a6h	160	18	variation	variation	NN
cord-006788-kz8i4a6h	160	19	in	in	IN
cord-006788-kz8i4a6h	160	20	the	the	DT
cord-006788-kz8i4a6h	160	21	rs11940694	rs11940694	NNP
cord-006788-kz8i4a6h	160	22	locus	locus	NN
cord-006788-kz8i4a6h	160	23	of	of	IN
cord-006788-kz8i4a6h	160	24	the	the	DT
cord-006788-kz8i4a6h	160	25	KLB	KLB	NNP
cord-006788-kz8i4a6h	160	26	gene	gene	NN
cord-006788-kz8i4a6h	160	27	in	in	IN
cord-006788-kz8i4a6h	160	28	association	association	NN
cord-006788-kz8i4a6h	160	29	with	with	IN
cord-006788-kz8i4a6h	160	30	the	the	DT
cord-006788-kz8i4a6h	160	31	aversion	aversion	NN
cord-006788-kz8i4a6h	160	32	for	for	IN
cord-006788-kz8i4a6h	160	33	alcohol	alcohol	NN
cord-006788-kz8i4a6h	160	34	[	[	-LRB-
cord-006788-kz8i4a6h	160	35	124	124	CD
cord-006788-kz8i4a6h	160	36	]	]	-RRB-
cord-006788-kz8i4a6h	160	37	.	.	.
cord-006788-kz8i4a6h	161	1	Neuronal	neuronal	JJ
cord-006788-kz8i4a6h	161	2	cell	cell	NN
cord-006788-kz8i4a6h	161	3	stress	stress	NN
cord-006788-kz8i4a6h	161	4	reaction	reaction	NN
cord-006788-kz8i4a6h	161	5	,	,	,
cord-006788-kz8i4a6h	161	6	such	such	JJ
cord-006788-kz8i4a6h	161	7	as	as	IN
cord-006788-kz8i4a6h	161	8	those	those	DT
cord-006788-kz8i4a6h	161	9	caused	cause	VBN
cord-006788-kz8i4a6h	161	10	by	by	IN
cord-006788-kz8i4a6h	161	11	disturbances	disturbance	NNS
cord-006788-kz8i4a6h	161	12	in	in	IN
cord-006788-kz8i4a6h	161	13	the	the	DT
cord-006788-kz8i4a6h	161	14	mitochondria	mitochondrion	NNS
cord-006788-kz8i4a6h	161	15	and	and	CC
cord-006788-kz8i4a6h	161	16	endoplasmic	endoplasmic	NN
cord-006788-kz8i4a6h	161	17	reticulum	reticulum	NN
cord-006788-kz8i4a6h	161	18	(	(	-LRB-
cord-006788-kz8i4a6h	161	19	ER	ER	NNP
cord-006788-kz8i4a6h	161	20	)	)	-RRB-
cord-006788-kz8i4a6h	161	21	,	,	,
cord-006788-kz8i4a6h	161	22	is	be	VBZ
cord-006788-kz8i4a6h	161	23	an	an	DT
cord-006788-kz8i4a6h	161	24	important	important	JJ
cord-006788-kz8i4a6h	161	25	factor	factor	NN
cord-006788-kz8i4a6h	161	26	in	in	IN
cord-006788-kz8i4a6h	161	27	the	the	DT
cord-006788-kz8i4a6h	161	28	development	development	NN
cord-006788-kz8i4a6h	161	29	of	of	IN
cord-006788-kz8i4a6h	161	30	neurodegenerative	neurodegenerative	JJ
cord-006788-kz8i4a6h	161	31	diseases	disease	NNS
cord-006788-kz8i4a6h	161	32	.	.	.
cord-006788-kz8i4a6h	162	1	Studies	study	NNS
cord-006788-kz8i4a6h	162	2	found	find	VBD
cord-006788-kz8i4a6h	162	3	that	that	IN
cord-006788-kz8i4a6h	162	4	the	the	DT
cord-006788-kz8i4a6h	162	5	integrated	integrate	VBN
cord-006788-kz8i4a6h	162	6	stress	stress	NN
cord-006788-kz8i4a6h	162	7	response	response	NN
cord-006788-kz8i4a6h	162	8	induces	induce	VBZ
cord-006788-kz8i4a6h	162	9	neuronal	neuronal	JJ
cord-006788-kz8i4a6h	162	10	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	162	11	,	,	,
cord-006788-kz8i4a6h	162	12	which	which	WDT
cord-006788-kz8i4a6h	162	13	presumably	presumably	RB
cord-006788-kz8i4a6h	162	14	serves	serve	VBZ
cord-006788-kz8i4a6h	162	15	to	to	TO
cord-006788-kz8i4a6h	162	16	attenuate	attenuate	VB
cord-006788-kz8i4a6h	162	17	stress	stress	NN
cord-006788-kz8i4a6h	162	18	and	and	CC
cord-006788-kz8i4a6h	162	19	neural	neural	JJ
cord-006788-kz8i4a6h	162	20	damage	damage	NN
cord-006788-kz8i4a6h	162	21	[	[	-LRB-
cord-006788-kz8i4a6h	162	22	125	125	CD
cord-006788-kz8i4a6h	162	23	]	]	-RRB-
cord-006788-kz8i4a6h	162	24	.	.	.
cord-006788-kz8i4a6h	163	1	In	in	IN
cord-006788-kz8i4a6h	163	2	addition	addition	NN
cord-006788-kz8i4a6h	163	3	to	to	IN
cord-006788-kz8i4a6h	163	4	the	the	DT
cord-006788-kz8i4a6h	163	5	liver	liver	NN
cord-006788-kz8i4a6h	163	6	,	,	,
cord-006788-kz8i4a6h	163	7	pancreas	pancrea	NNS
cord-006788-kz8i4a6h	163	8	,	,	,
cord-006788-kz8i4a6h	163	9	and	and	CC
cord-006788-kz8i4a6h	163	10	adipose	adipose	JJ
cord-006788-kz8i4a6h	163	11	tissues	tissue	NNS
cord-006788-kz8i4a6h	163	12	,	,	,
cord-006788-kz8i4a6h	163	13	cardiac	cardiac	JJ
cord-006788-kz8i4a6h	163	14	muscle	muscle	NN
cord-006788-kz8i4a6h	163	15	produces	produce	VBZ
cord-006788-kz8i4a6h	163	16	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	163	17	in	in	IN
cord-006788-kz8i4a6h	163	18	response	response	NN
cord-006788-kz8i4a6h	163	19	to	to	IN
cord-006788-kz8i4a6h	163	20	cardiac	cardiac	JJ
cord-006788-kz8i4a6h	163	21	stress	stress	NN
cord-006788-kz8i4a6h	163	22	,	,	,
cord-006788-kz8i4a6h	163	23	cardio	cardio	NN
cord-006788-kz8i4a6h	163	24	exercise	exercise	NN
cord-006788-kz8i4a6h	163	25	,	,	,
cord-006788-kz8i4a6h	163	26	and	and	CC
cord-006788-kz8i4a6h	163	27	endurance	endurance	NN
cord-006788-kz8i4a6h	163	28	training	training	NN
cord-006788-kz8i4a6h	163	29	[	[	-LRB-
cord-006788-kz8i4a6h	163	30	126	126	CD
cord-006788-kz8i4a6h	163	31	,	,	,
cord-006788-kz8i4a6h	163	32	127	127	CD
cord-006788-kz8i4a6h	163	33	]	]	-RRB-
cord-006788-kz8i4a6h	163	34	,	,	,
cord-006788-kz8i4a6h	163	35	which	which	WDT
cord-006788-kz8i4a6h	163	36	then	then	RB
cord-006788-kz8i4a6h	163	37	speeds	speed	VBZ
cord-006788-kz8i4a6h	163	38	up	up	RP
cord-006788-kz8i4a6h	163	39	glucose	glucose	NN
cord-006788-kz8i4a6h	163	40	uptake	uptake	NN
cord-006788-kz8i4a6h	163	41	,	,	,
cord-006788-kz8i4a6h	163	42	lipid	lipid	NN
cord-006788-kz8i4a6h	163	43	catabolism	catabolism	NN
cord-006788-kz8i4a6h	163	44	,	,	,
cord-006788-kz8i4a6h	163	45	and	and	CC
cord-006788-kz8i4a6h	163	46	energy	energy	NN
cord-006788-kz8i4a6h	163	47	metabolism	metabolism	NN
cord-006788-kz8i4a6h	163	48	,	,	,
cord-006788-kz8i4a6h	163	49	and	and	CC
cord-006788-kz8i4a6h	163	50	protects	protect	VBZ
cord-006788-kz8i4a6h	163	51	against	against	IN
cord-006788-kz8i4a6h	163	52	cardiovascular	cardiovascular	JJ
cord-006788-kz8i4a6h	163	53	stress	stress	NN
cord-006788-kz8i4a6h	163	54	damage	damage	NN
cord-006788-kz8i4a6h	163	55	,	,	,
cord-006788-kz8i4a6h	163	56	apoptosis	apoptosis	NN
cord-006788-kz8i4a6h	163	57	,	,	,
cord-006788-kz8i4a6h	163	58	and	and	CC
cord-006788-kz8i4a6h	163	59	heart	heart	NN
cord-006788-kz8i4a6h	163	60	dysfunctions	dysfunction	NNS
cord-006788-kz8i4a6h	163	61	,	,	,
cord-006788-kz8i4a6h	163	62	such	such	JJ
cord-006788-kz8i4a6h	163	63	as	as	IN
cord-006788-kz8i4a6h	163	64	cardiac	cardiac	JJ
cord-006788-kz8i4a6h	163	65	hypertrophy	hypertrophy	NN
cord-006788-kz8i4a6h	163	66	,	,	,
cord-006788-kz8i4a6h	163	67	myopathy	myopathy	NN
cord-006788-kz8i4a6h	163	68	,	,	,
cord-006788-kz8i4a6h	163	69	steatosis	steatosis	NN
cord-006788-kz8i4a6h	163	70	,	,	,
cord-006788-kz8i4a6h	163	71	ischemic	ischemic	JJ
cord-006788-kz8i4a6h	163	72	infarction	infarction	NN
cord-006788-kz8i4a6h	163	73	,	,	,
cord-006788-kz8i4a6h	163	74	and	and	CC
cord-006788-kz8i4a6h	163	75	atherosclerosis	atherosclerosis	NN
cord-006788-kz8i4a6h	163	76	[	[	-LRB-
cord-006788-kz8i4a6h	163	77	128	128	CD
cord-006788-kz8i4a6h	163	78	]	]	-RRB-
cord-006788-kz8i4a6h	163	79	[	[	-LRB-
cord-006788-kz8i4a6h	163	80	129	129	CD
cord-006788-kz8i4a6h	163	81	]	]	-RRB-
cord-006788-kz8i4a6h	163	82	[	[	-LRB-
cord-006788-kz8i4a6h	163	83	130	130	CD
cord-006788-kz8i4a6h	163	84	]	]	-RRB-
cord-006788-kz8i4a6h	163	85	[	[	-LRB-
cord-006788-kz8i4a6h	163	86	131	131	CD
cord-006788-kz8i4a6h	163	87	]	]	-RRB-
cord-006788-kz8i4a6h	164	1	[	[	-LRB-
cord-006788-kz8i4a6h	164	2	132	132	CD
cord-006788-kz8i4a6h	164	3	]	]	-RRB-
cord-006788-kz8i4a6h	164	4	.	.	.
cord-006788-kz8i4a6h	165	1	Through	through	IN
cord-006788-kz8i4a6h	165	2	a	a	DT
cord-006788-kz8i4a6h	165	3	multiorgan	multiorgan	NN
cord-006788-kz8i4a6h	165	4	crosstalk	crosstalk	NN
cord-006788-kz8i4a6h	165	5	,	,	,
cord-006788-kz8i4a6h	165	6	hepatic	hepatic	JJ
cord-006788-kz8i4a6h	165	7	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	165	8	drives	drive	VBZ
cord-006788-kz8i4a6h	165	9	the	the	DT
cord-006788-kz8i4a6h	165	10	expression	expression	NN
cord-006788-kz8i4a6h	165	11	of	of	IN
cord-006788-kz8i4a6h	165	12	angiotensin	angiotensin	NN
cord-006788-kz8i4a6h	165	13	-	-	HYPH
cord-006788-kz8i4a6h	165	14	converting	convert	VBG
cord-006788-kz8i4a6h	165	15	enzyme	enzyme	NN
cord-006788-kz8i4a6h	165	16	2	2	CD
cord-006788-kz8i4a6h	165	17	in	in	IN
cord-006788-kz8i4a6h	165	18	adipocytes	adipocyte	NNS
cord-006788-kz8i4a6h	165	19	and	and	CC
cord-006788-kz8i4a6h	165	20	renal	renal	JJ
cord-006788-kz8i4a6h	165	21	cells	cell	NNS
cord-006788-kz8i4a6h	165	22	,	,	,
cord-006788-kz8i4a6h	165	23	which	which	WDT
cord-006788-kz8i4a6h	165	24	hydrolyzes	hydrolyze	VBZ
cord-006788-kz8i4a6h	165	25	angiotensin	angiotensin	NN
cord-006788-kz8i4a6h	165	26	II	II	NNP
cord-006788-kz8i4a6h	165	27	to	to	IN
cord-006788-kz8i4a6h	165	28	active	active	JJ
cord-006788-kz8i4a6h	165	29	vasodilator	vasodilator	NN
cord-006788-kz8i4a6h	165	30	angiotensin-(1	angiotensin-(1	CD
cord-006788-kz8i4a6h	165	31	-	-	SYM
cord-006788-kz8i4a6h	165	32	7	7	CD
cord-006788-kz8i4a6h	165	33	)	)	-RRB-
cord-006788-kz8i4a6h	165	34	in	in	IN
cord-006788-kz8i4a6h	165	35	the	the	DT
cord-006788-kz8i4a6h	165	36	renin	renin	NN
cord-006788-kz8i4a6h	165	37	-	-	HYPH
cord-006788-kz8i4a6h	165	38	angiotensin	angiotensin	NN
cord-006788-kz8i4a6h	165	39	system	system	NN
cord-006788-kz8i4a6h	165	40	,	,	,
cord-006788-kz8i4a6h	165	41	thereby	thereby	RB
cord-006788-kz8i4a6h	165	42	alleviating	alleviate	VBG
cord-006788-kz8i4a6h	165	43	angiotensin	angiotensin	NN
cord-006788-kz8i4a6h	165	44	II	II	NNP
cord-006788-kz8i4a6h	165	45	-	-	HYPH
cord-006788-kz8i4a6h	165	46	associated	associate	VBN
cord-006788-kz8i4a6h	165	47	hypertension	hypertension	NN
cord-006788-kz8i4a6h	165	48	and	and	CC
cord-006788-kz8i4a6h	165	49	reversing	reverse	VBG
cord-006788-kz8i4a6h	165	50	vascular	vascular	JJ
cord-006788-kz8i4a6h	165	51	damage	damage	NN
cord-006788-kz8i4a6h	165	52	[	[	-LRB-
cord-006788-kz8i4a6h	165	53	133	133	CD
cord-006788-kz8i4a6h	165	54	]	]	-RRB-
cord-006788-kz8i4a6h	165	55	.	.	.
cord-006788-kz8i4a6h	166	1	Skeletal	skeletal	JJ
cord-006788-kz8i4a6h	166	2	muscle	muscle	NN
cord-006788-kz8i4a6h	166	3	under	under	IN
cord-006788-kz8i4a6h	166	4	the	the	DT
cord-006788-kz8i4a6h	166	5	bouts	bout	NNS
cord-006788-kz8i4a6h	166	6	of	of	IN
cord-006788-kz8i4a6h	166	7	exercise	exercise	NN
cord-006788-kz8i4a6h	166	8	or	or	CC
cord-006788-kz8i4a6h	166	9	stress	stress	NN
cord-006788-kz8i4a6h	166	10	,	,	,
cord-006788-kz8i4a6h	166	11	such	such	JJ
cord-006788-kz8i4a6h	166	12	as	as	IN
cord-006788-kz8i4a6h	166	13	mitochondrial	mitochondrial	JJ
cord-006788-kz8i4a6h	166	14	myopathies	myopathy	NNS
cord-006788-kz8i4a6h	166	15	,	,	,
cord-006788-kz8i4a6h	166	16	also	also	RB
cord-006788-kz8i4a6h	166	17	induces	induce	VBZ
cord-006788-kz8i4a6h	166	18	FGF21	fgf21	JJ
cord-006788-kz8i4a6h	166	19	expression	expression	NN
cord-006788-kz8i4a6h	166	20	[	[	-LRB-
cord-006788-kz8i4a6h	166	21	134	134	CD
cord-006788-kz8i4a6h	166	22	]	]	-RRB-
cord-006788-kz8i4a6h	167	1	[	[	-LRB-
cord-006788-kz8i4a6h	167	2	135	135	CD
cord-006788-kz8i4a6h	167	3	]	]	-RRB-
cord-006788-kz8i4a6h	167	4	[	[	-LRB-
cord-006788-kz8i4a6h	167	5	136	136	CD
cord-006788-kz8i4a6h	167	6	]	]	-RRB-
cord-006788-kz8i4a6h	167	7	.	.	.
cord-006788-kz8i4a6h	168	1	In	in	IN
cord-006788-kz8i4a6h	168	2	turn	turn	NN
cord-006788-kz8i4a6h	168	3	,	,	,
cord-006788-kz8i4a6h	168	4	FGF21	fgf21	JJ
cord-006788-kz8i4a6h	168	5	acts	act	NNS
cord-006788-kz8i4a6h	168	6	on	on	IN
cord-006788-kz8i4a6h	168	7	muscle	muscle	NN
cord-006788-kz8i4a6h	168	8	and	and	CC
cord-006788-kz8i4a6h	168	9	adipose	adipose	JJ
cord-006788-kz8i4a6h	168	10	tissue	tissue	NN
cord-006788-kz8i4a6h	168	11	to	to	TO
cord-006788-kz8i4a6h	168	12	reduce	reduce	VB
cord-006788-kz8i4a6h	168	13	lipid	lipid	NN
cord-006788-kz8i4a6h	168	14	load	load	NN
cord-006788-kz8i4a6h	168	15	by	by	IN
cord-006788-kz8i4a6h	168	16	increasing	increase	VBG
cord-006788-kz8i4a6h	168	17	lipolysis	lipolysis	NN
cord-006788-kz8i4a6h	168	18	,	,	,
cord-006788-kz8i4a6h	168	19	fatty	fatty	JJ
cord-006788-kz8i4a6h	168	20	acid	acid	NN
cord-006788-kz8i4a6h	168	21	utilization	utilization	NN
cord-006788-kz8i4a6h	168	22	,	,	,
cord-006788-kz8i4a6h	168	23	energy	energy	NN
cord-006788-kz8i4a6h	168	24	expenditure	expenditure	NN
cord-006788-kz8i4a6h	168	25	,	,	,
cord-006788-kz8i4a6h	168	26	and	and	CC
cord-006788-kz8i4a6h	168	27	insulin	insulin	NN
cord-006788-kz8i4a6h	168	28	sensitivity	sensitivity	NN
cord-006788-kz8i4a6h	168	29	,	,	,
cord-006788-kz8i4a6h	168	30	thereby	thereby	RB
cord-006788-kz8i4a6h	168	31	preventing	prevent	VBG
cord-006788-kz8i4a6h	168	32	diet	diet	NN
cord-006788-kz8i4a6h	168	33	-	-	HYPH
cord-006788-kz8i4a6h	168	34	induced	induce	VBN
cord-006788-kz8i4a6h	168	35	obesity	obesity	NN
cord-006788-kz8i4a6h	168	36	and	and	CC
cord-006788-kz8i4a6h	168	37	insulin	insulin	NN
cord-006788-kz8i4a6h	168	38	resistance	resistance	NN
cord-006788-kz8i4a6h	168	39	[	[	-LRB-
cord-006788-kz8i4a6h	168	40	137	137	CD
cord-006788-kz8i4a6h	168	41	]	]	-RRB-
cord-006788-kz8i4a6h	169	1	[	[	-LRB-
cord-006788-kz8i4a6h	169	2	138	138	CD
cord-006788-kz8i4a6h	169	3	]	]	-RRB-
cord-006788-kz8i4a6h	170	1	[	[	-LRB-
cord-006788-kz8i4a6h	170	2	139	139	CD
cord-006788-kz8i4a6h	170	3	]	]	-RRB-
cord-006788-kz8i4a6h	170	4	[	[	-LRB-
cord-006788-kz8i4a6h	170	5	140	140	CD
cord-006788-kz8i4a6h	170	6	]	]	-RRB-
cord-006788-kz8i4a6h	170	7	.	.	.
cord-006788-kz8i4a6h	171	1	Hepatic	hepatic	JJ
cord-006788-kz8i4a6h	171	2	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	171	3	acts	act	NNS
cord-006788-kz8i4a6h	171	4	on	on	IN
cord-006788-kz8i4a6h	171	5	the	the	DT
cord-006788-kz8i4a6h	171	6	paraventricular	paraventricular	NNP
cord-006788-kz8i4a6h	171	7	nucleus	nucleus	NN
cord-006788-kz8i4a6h	171	8	in	in	IN
cord-006788-kz8i4a6h	171	9	the	the	DT
cord-006788-kz8i4a6h	171	10	hypothalamus	hypothalamus	NN
cord-006788-kz8i4a6h	171	11	to	to	TO
cord-006788-kz8i4a6h	171	12	drive	drive	VB
cord-006788-kz8i4a6h	171	13	the	the	DT
cord-006788-kz8i4a6h	171	14	release	release	NN
cord-006788-kz8i4a6h	171	15	of	of	IN
cord-006788-kz8i4a6h	171	16	corticotropin	corticotropin	NNP
cord-006788-kz8i4a6h	171	17	-	-	HYPH
cord-006788-kz8i4a6h	171	18	releasing	release	VBG
cord-006788-kz8i4a6h	171	19	factor	factor	NN
cord-006788-kz8i4a6h	171	20	,	,	,
cord-006788-kz8i4a6h	171	21	which	which	WDT
cord-006788-kz8i4a6h	171	22	then	then	RB
cord-006788-kz8i4a6h	171	23	stimulates	stimulate	VBZ
cord-006788-kz8i4a6h	171	24	the	the	DT
cord-006788-kz8i4a6h	171	25	involuntary	involuntary	JJ
cord-006788-kz8i4a6h	171	26	sympathetic	sympathetic	JJ
cord-006788-kz8i4a6h	171	27	nerve	nerve	NN
cord-006788-kz8i4a6h	171	28	activity	activity	NN
cord-006788-kz8i4a6h	171	29	.	.	.
cord-006788-kz8i4a6h	172	1	This	this	DT
cord-006788-kz8i4a6h	172	2	leads	lead	VBZ
cord-006788-kz8i4a6h	172	3	to	to	IN
cord-006788-kz8i4a6h	172	4	the	the	DT
cord-006788-kz8i4a6h	172	5	activation	activation	NN
cord-006788-kz8i4a6h	172	6	of	of	IN
cord-006788-kz8i4a6h	172	7	brown	brown	JJ
cord-006788-kz8i4a6h	172	8	adipose	adipose	JJ
cord-006788-kz8i4a6h	172	9	tissue	tissue	NN
cord-006788-kz8i4a6h	172	10	by	by	IN
cord-006788-kz8i4a6h	172	11	upregulaing	upregulae	VBG
cord-006788-kz8i4a6h	172	12	UCP1	UCP1	NNP
cord-006788-kz8i4a6h	172	13	and	and	CC
cord-006788-kz8i4a6h	172	14	increases	increase	NNS
cord-006788-kz8i4a6h	172	15	of	of	IN
cord-006788-kz8i4a6h	172	16	glucose	glucose	NN
cord-006788-kz8i4a6h	172	17	uptake	uptake	NN
cord-006788-kz8i4a6h	172	18	,	,	,
cord-006788-kz8i4a6h	172	19	lipolysis	lipolysis	NN
cord-006788-kz8i4a6h	172	20	,	,	,
cord-006788-kz8i4a6h	173	1	mitochondrial	mitochondrial	JJ
cord-006788-kz8i4a6h	173	2	oxidation	oxidation	NN
cord-006788-kz8i4a6h	173	3	of	of	IN
cord-006788-kz8i4a6h	173	4	fatty	fatty	JJ
cord-006788-kz8i4a6h	173	5	acids	acid	NNS
cord-006788-kz8i4a6h	173	6	and	and	CC
cord-006788-kz8i4a6h	173	7	glucose	glucose	NN
cord-006788-kz8i4a6h	173	8	,	,	,
cord-006788-kz8i4a6h	173	9	body	body	NN
cord-006788-kz8i4a6h	173	10	heat	heat	NN
cord-006788-kz8i4a6h	173	11	generation	generation	NN
cord-006788-kz8i4a6h	173	12	,	,	,
cord-006788-kz8i4a6h	173	13	and	and	CC
cord-006788-kz8i4a6h	173	14	weight	weight	NN
cord-006788-kz8i4a6h	173	15	loss	loss	NN
cord-006788-kz8i4a6h	173	16	[	[	-LRB-
cord-006788-kz8i4a6h	173	17	141	141	CD
cord-006788-kz8i4a6h	173	18	,	,	,
cord-006788-kz8i4a6h	173	19	142	142	CD
cord-006788-kz8i4a6h	173	20	]	]	-RRB-
cord-006788-kz8i4a6h	173	21	.	.	.
cord-006788-kz8i4a6h	174	1	The	the	DT
cord-006788-kz8i4a6h	174	2	increase	increase	NN
cord-006788-kz8i4a6h	174	3	in	in	IN
cord-006788-kz8i4a6h	174	4	corticotropin	corticotropin	NNP
cord-006788-kz8i4a6h	174	5	-	-	HYPH
cord-006788-kz8i4a6h	174	6	releasing	release	VBG
cord-006788-kz8i4a6h	174	7	factor	factor	NN
cord-006788-kz8i4a6h	174	8	levels	level	NNS
cord-006788-kz8i4a6h	174	9	may	may	MD
cord-006788-kz8i4a6h	174	10	also	also	RB
cord-006788-kz8i4a6h	174	11	stimulate	stimulate	VB
cord-006788-kz8i4a6h	174	12	the	the	DT
cord-006788-kz8i4a6h	174	13	pituitary	pituitary	JJ
cord-006788-kz8i4a6h	174	14	gland	gland	NN
cord-006788-kz8i4a6h	174	15	to	to	TO
cord-006788-kz8i4a6h	174	16	release	release	VB
cord-006788-kz8i4a6h	174	17	adrenocorticotrophic	adrenocorticotrophic	JJ
cord-006788-kz8i4a6h	174	18	hormone	hormone	NN
cord-006788-kz8i4a6h	174	19	and	and	CC
cord-006788-kz8i4a6h	174	20	subsequent	subsequent	JJ
cord-006788-kz8i4a6h	174	21	corticoster	corticoster	JJ
cord-006788-kz8i4a6h	174	22	-	-	HYPH
cord-006788-kz8i4a6h	174	23	one	one	CD
cord-006788-kz8i4a6h	174	24	production	production	NN
cord-006788-kz8i4a6h	174	25	in	in	IN
cord-006788-kz8i4a6h	174	26	adrenal	adrenal	JJ
cord-006788-kz8i4a6h	174	27	cortex	cortex	NN
cord-006788-kz8i4a6h	174	28	,	,	,
cord-006788-kz8i4a6h	174	29	leading	lead	VBG
cord-006788-kz8i4a6h	174	30	to	to	IN
cord-006788-kz8i4a6h	174	31	increased	increase	VBN
cord-006788-kz8i4a6h	174	32	hepatic	hepatic	JJ
cord-006788-kz8i4a6h	174	33	gluconeogenesis	gluconeogenesis	NN
cord-006788-kz8i4a6h	174	34	during	during	IN
cord-006788-kz8i4a6h	174	35	prolonged	prolong	VBN
cord-006788-kz8i4a6h	174	36	fasting	fasting	NN
cord-006788-kz8i4a6h	174	37	to	to	TO
cord-006788-kz8i4a6h	174	38	prevent	prevent	VB
cord-006788-kz8i4a6h	174	39	hypoglycemia	hypoglycemia	NN
cord-006788-kz8i4a6h	174	40	[	[	-LRB-
cord-006788-kz8i4a6h	174	41	143	143	CD
cord-006788-kz8i4a6h	174	42	]	]	-RRB-
cord-006788-kz8i4a6h	174	43	.	.	.
cord-006788-kz8i4a6h	175	1	Hepatic	hepatic	JJ
cord-006788-kz8i4a6h	175	2	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	175	3	acts	act	NNS
cord-006788-kz8i4a6h	175	4	on	on	IN
cord-006788-kz8i4a6h	175	5	the	the	DT
cord-006788-kz8i4a6h	175	6	suprachiasmatic	suprachiasmatic	JJ
cord-006788-kz8i4a6h	175	7	nucleus	nucleus	NN
cord-006788-kz8i4a6h	175	8	(	(	-LRB-
cord-006788-kz8i4a6h	175	9	SCN	SCN	NNP
cord-006788-kz8i4a6h	175	10	)	)	-RRB-
cord-006788-kz8i4a6h	175	11	in	in	IN
cord-006788-kz8i4a6h	175	12	the	the	DT
cord-006788-kz8i4a6h	175	13	hypothalamus	hypothalamus	NN
cord-006788-kz8i4a6h	175	14	to	to	TO
cord-006788-kz8i4a6h	175	15	suppress	suppress	VB
cord-006788-kz8i4a6h	175	16	the	the	DT
cord-006788-kz8i4a6h	175	17	vasopressin	vasopressin	NN
cord-006788-kz8i4a6h	175	18	-	-	HYPH
cord-006788-kz8i4a6h	175	19	kisspeptin	kisspeptin	NNP
cord-006788-kz8i4a6h	175	20	and	and	CC
cord-006788-kz8i4a6h	175	21	gonadotropinreleasing	gonadotropinrelease	VBG
cord-006788-kz8i4a6h	175	22	hormone	hormone	NN
cord-006788-kz8i4a6h	175	23	signaling	signal	VBG
cord-006788-kz8i4a6h	175	24	cascade	cascade	NN
cord-006788-kz8i4a6h	175	25	,	,	,
cord-006788-kz8i4a6h	175	26	which	which	WDT
cord-006788-kz8i4a6h	175	27	then	then	RB
cord-006788-kz8i4a6h	175	28	inhibit	inhibit	VBP
cord-006788-kz8i4a6h	175	29	the	the	DT
cord-006788-kz8i4a6h	175	30	proestrus	proestrus	JJ
cord-006788-kz8i4a6h	175	31	surge	surge	NN
cord-006788-kz8i4a6h	175	32	in	in	IN
cord-006788-kz8i4a6h	175	33	luteinizing	luteinize	VBG
cord-006788-kz8i4a6h	175	34	hormone	hormone	NN
cord-006788-kz8i4a6h	175	35	from	from	IN
cord-006788-kz8i4a6h	175	36	anterior	anterior	JJ
cord-006788-kz8i4a6h	175	37	pituitary	pituitary	JJ
cord-006788-kz8i4a6h	175	38	gland	gland	NN
cord-006788-kz8i4a6h	175	39	,	,	,
cord-006788-kz8i4a6h	175	40	thereby	thereby	RB
cord-006788-kz8i4a6h	175	41	contributing	contribute	VBG
cord-006788-kz8i4a6h	175	42	to	to	IN
cord-006788-kz8i4a6h	175	43	female	female	JJ
cord-006788-kz8i4a6h	175	44	infertility	infertility	NN
cord-006788-kz8i4a6h	175	45	in	in	IN
cord-006788-kz8i4a6h	175	46	response	response	NN
cord-006788-kz8i4a6h	175	47	to	to	IN
cord-006788-kz8i4a6h	175	48	nutritional	nutritional	JJ
cord-006788-kz8i4a6h	175	49	challenge	challenge	NN
cord-006788-kz8i4a6h	175	50	,	,	,
cord-006788-kz8i4a6h	175	51	such	such	JJ
cord-006788-kz8i4a6h	175	52	as	as	IN
cord-006788-kz8i4a6h	175	53	prolonged	prolonged	JJ
cord-006788-kz8i4a6h	175	54	starvation	starvation	NN
cord-006788-kz8i4a6h	175	55	[	[	-LRB-
cord-006788-kz8i4a6h	175	56	144	144	CD
cord-006788-kz8i4a6h	175	57	]	]	-RRB-
cord-006788-kz8i4a6h	175	58	.	.	.
cord-006788-kz8i4a6h	176	1	The	the	DT
cord-006788-kz8i4a6h	176	2	SCN	SCN	NNP
cord-006788-kz8i4a6h	176	3	action	action	NN
cord-006788-kz8i4a6h	176	4	of	of	IN
cord-006788-kz8i4a6h	176	5	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	176	6	may	may	MD
cord-006788-kz8i4a6h	176	7	also	also	RB
cord-006788-kz8i4a6h	176	8	alter	alter	VB
cord-006788-kz8i4a6h	176	9	circadian	circadian	NN
cord-006788-kz8i4a6h	176	10	behavior	behavior	NN
cord-006788-kz8i4a6h	176	11	[	[	-LRB-
cord-006788-kz8i4a6h	176	12	145	145	CD
cord-006788-kz8i4a6h	176	13	]	]	-RRB-
cord-006788-kz8i4a6h	176	14	.	.	.
cord-006788-kz8i4a6h	177	1	By	by	IN
cord-006788-kz8i4a6h	177	2	increasing	increase	VBG
cord-006788-kz8i4a6h	177	3	neuropeptide	neuropeptide	NN
cord-006788-kz8i4a6h	177	4	Y	Y	NNP
cord-006788-kz8i4a6h	177	5	levels	level	NNS
cord-006788-kz8i4a6h	177	6	and	and	CC
cord-006788-kz8i4a6h	177	7	Y1	Y1	NNP
cord-006788-kz8i4a6h	177	8	receptor	receptor	NN
cord-006788-kz8i4a6h	177	9	activation	activation	NN
cord-006788-kz8i4a6h	177	10	,	,	,
cord-006788-kz8i4a6h	177	11	the	the	DT
cord-006788-kz8i4a6h	177	12	hypothalamus	hypothalamus	NN
cord-006788-kz8i4a6h	177	13	action	action	NN
cord-006788-kz8i4a6h	177	14	of	of	IN
cord-006788-kz8i4a6h	177	15	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	177	16	may	may	MD
cord-006788-kz8i4a6h	177	17	decrease	decrease	VB
cord-006788-kz8i4a6h	177	18	locomotive	locomotive	JJ
cord-006788-kz8i4a6h	177	19	activity	activity	NN
cord-006788-kz8i4a6h	177	20	,	,	,
cord-006788-kz8i4a6h	177	21	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	177	22	rate	rate	NN
cord-006788-kz8i4a6h	177	23	,	,	,
cord-006788-kz8i4a6h	177	24	and	and	CC
cord-006788-kz8i4a6h	177	25	body	body	NN
cord-006788-kz8i4a6h	177	26	temperature	temperature	NN
cord-006788-kz8i4a6h	177	27	,	,	,
cord-006788-kz8i4a6h	177	28	leading	lead	VBG
cord-006788-kz8i4a6h	177	29	to	to	IN
cord-006788-kz8i4a6h	177	30	torpor	torpor	NN
cord-006788-kz8i4a6h	177	31	under	under	IN
cord-006788-kz8i4a6h	177	32	nutrition	nutrition	NN
cord-006788-kz8i4a6h	177	33	limitation	limitation	NN
cord-006788-kz8i4a6h	177	34	[	[	-LRB-
cord-006788-kz8i4a6h	177	35	146	146	CD
cord-006788-kz8i4a6h	177	36	]	]	-RRB-
cord-006788-kz8i4a6h	177	37	.	.	.
cord-006788-kz8i4a6h	178	1	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	178	2	may	may	MD
cord-006788-kz8i4a6h	178	3	also	also	RB
cord-006788-kz8i4a6h	178	4	act	act	VB
cord-006788-kz8i4a6h	178	5	on	on	IN
cord-006788-kz8i4a6h	178	6	the	the	DT
cord-006788-kz8i4a6h	178	7	hippocampus	hippocampus	NN
cord-006788-kz8i4a6h	178	8	to	to	TO
cord-006788-kz8i4a6h	178	9	decrease	decrease	VB
cord-006788-kz8i4a6h	178	10	reactive	reactive	JJ
cord-006788-kz8i4a6h	178	11	oxygen	oxygen	NN
cord-006788-kz8i4a6h	178	12	species	specie	NNS
cord-006788-kz8i4a6h	178	13	and	and	CC
cord-006788-kz8i4a6h	178	14	inflammatory	inflammatory	JJ
cord-006788-kz8i4a6h	178	15	damage	damage	NN
cord-006788-kz8i4a6h	178	16	,	,	,
cord-006788-kz8i4a6h	178	17	thus	thus	RB
cord-006788-kz8i4a6h	178	18	decreasing	decrease	VBG
cord-006788-kz8i4a6h	178	19	brain	brain	NN
cord-006788-kz8i4a6h	178	20	cell	cell	NN
cord-006788-kz8i4a6h	178	21	damage	damage	NN
cord-006788-kz8i4a6h	178	22	and	and	CC
cord-006788-kz8i4a6h	178	23	improving	improve	VBG
cord-006788-kz8i4a6h	178	24	cognition	cognition	NN
cord-006788-kz8i4a6h	178	25	[	[	-LRB-
cord-006788-kz8i4a6h	178	26	147	147	CD
cord-006788-kz8i4a6h	178	27	,	,	,
cord-006788-kz8i4a6h	178	28	148	148	CD
cord-006788-kz8i4a6h	178	29	]	]	-RRB-
cord-006788-kz8i4a6h	178	30	.	.	.
cord-006788-kz8i4a6h	179	1	The	the	DT
cord-006788-kz8i4a6h	179	2	endocrine	endocrine	JJ
cord-006788-kz8i4a6h	179	3	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	179	4	axes	axis	NNS
cord-006788-kz8i4a6h	179	5	as	as	RB
cord-006788-kz8i4a6h	179	6	well	well	RB
cord-006788-kz8i4a6h	179	7	as	as	IN
cord-006788-kz8i4a6h	179	8	the	the	DT
cord-006788-kz8i4a6h	179	9	paracrine	paracrine	JJ
cord-006788-kz8i4a6h	179	10	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	179	11	axes	axis	NNS
cord-006788-kz8i4a6h	179	12	within	within	IN
cord-006788-kz8i4a6h	179	13	the	the	DT
cord-006788-kz8i4a6h	179	14	local	local	JJ
cord-006788-kz8i4a6h	179	15	tissue	tissue	NN
cord-006788-kz8i4a6h	179	16	compartments	compartment	NNS
cord-006788-kz8i4a6h	179	17	have	have	VBP
cord-006788-kz8i4a6h	179	18	been	be	VBN
cord-006788-kz8i4a6h	179	19	shown	show	VBN
cord-006788-kz8i4a6h	179	20	in	in	IN
cord-006788-kz8i4a6h	179	21	many	many	JJ
cord-006788-kz8i4a6h	179	22	tissues	tissue	NNS
cord-006788-kz8i4a6h	179	23	and	and	CC
cord-006788-kz8i4a6h	179	24	organs	organ	NNS
cord-006788-kz8i4a6h	179	25	to	to	TO
cord-006788-kz8i4a6h	179	26	counteract	counteract	VB
cord-006788-kz8i4a6h	179	27	stress	stress	NN
cord-006788-kz8i4a6h	179	28	response	response	NN
cord-006788-kz8i4a6h	179	29	and	and	CC
cord-006788-kz8i4a6h	179	30	attenuate	attenuate	VB
cord-006788-kz8i4a6h	179	31	stress	stress	NN
cord-006788-kz8i4a6h	179	32	-	-	HYPH
cord-006788-kz8i4a6h	179	33	ensued	ensue	VBD
cord-006788-kz8i4a6h	179	34	inflammation	inflammation	NN
cord-006788-kz8i4a6h	179	35	and	and	CC
cord-006788-kz8i4a6h	179	36	inflammatory	inflammatory	JJ
cord-006788-kz8i4a6h	179	37	damage	damage	NN
cord-006788-kz8i4a6h	179	38	[	[	-LRB-
cord-006788-kz8i4a6h	179	39	7	7	CD
cord-006788-kz8i4a6h	179	40	,	,	,
cord-006788-kz8i4a6h	179	41	104	104	CD
cord-006788-kz8i4a6h	179	42	,	,	,
cord-006788-kz8i4a6h	179	43	117	117	CD
cord-006788-kz8i4a6h	179	44	]	]	-RRB-
cord-006788-kz8i4a6h	179	45	.	.	.
cord-006788-kz8i4a6h	180	1	Therefore	therefore	RB
cord-006788-kz8i4a6h	180	2	,	,	,
cord-006788-kz8i4a6h	180	3	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	180	4	is	be	VBZ
cord-006788-kz8i4a6h	180	5	not	not	RB
cord-006788-kz8i4a6h	180	6	only	only	RB
cord-006788-kz8i4a6h	180	7	a	a	DT
cord-006788-kz8i4a6h	180	8	stress	stress	NN
cord-006788-kz8i4a6h	180	9	-	-	HYPH
cord-006788-kz8i4a6h	180	10	responsive	responsive	JJ
cord-006788-kz8i4a6h	180	11	or	or	CC
cord-006788-kz8i4a6h	180	12	-induced	-induced	JJ
cord-006788-kz8i4a6h	180	13	factor	factor	NN
cord-006788-kz8i4a6h	180	14	but	but	CC
cord-006788-kz8i4a6h	180	15	also	also	RB
cord-006788-kz8i4a6h	180	16	an	an	DT
cord-006788-kz8i4a6h	180	17	anti	anti	JJ
cord-006788-kz8i4a6h	180	18	-	-	JJ
cord-006788-kz8i4a6h	180	19	stress	stress	JJ
cord-006788-kz8i4a6h	180	20	and	and	CC
cord-006788-kz8i4a6h	180	21	anti	anti	JJ
cord-006788-kz8i4a6h	180	22	-	-	JJ
cord-006788-kz8i4a6h	180	23	inflammatory	inflammatory	JJ
cord-006788-kz8i4a6h	180	24	factor	factor	NN
cord-006788-kz8i4a6h	180	25	.	.	.
cord-006788-kz8i4a6h	181	1	The	the	DT
cord-006788-kz8i4a6h	181	2	stress	stress	NN
cord-006788-kz8i4a6h	181	3	-	-	HYPH
cord-006788-kz8i4a6h	181	4	offsetting	offset	VBG
cord-006788-kz8i4a6h	181	5	effects	effect	NNS
cord-006788-kz8i4a6h	181	6	,	,	,
cord-006788-kz8i4a6h	181	7	in	in	IN
cord-006788-kz8i4a6h	181	8	particular	particular	JJ
cord-006788-kz8i4a6h	181	9	the	the	DT
cord-006788-kz8i4a6h	181	10	anti	anti	JJ
cord-006788-kz8i4a6h	181	11	-	-	JJ
cord-006788-kz8i4a6h	181	12	inflammatory	inflammatory	JJ
cord-006788-kz8i4a6h	181	13	activities	activity	NNS
cord-006788-kz8i4a6h	181	14	,	,	,
cord-006788-kz8i4a6h	181	15	can	can	MD
cord-006788-kz8i4a6h	181	16	be	be	VB
cord-006788-kz8i4a6h	181	17	attributed	attribute	VBN
cord-006788-kz8i4a6h	181	18	to	to	IN
cord-006788-kz8i4a6h	181	19	the	the	DT
cord-006788-kz8i4a6h	181	20	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	181	21	effects	effect	NNS
cord-006788-kz8i4a6h	181	22	of	of	IN
cord-006788-kz8i4a6h	181	23	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	181	24	axes	axis	NNS
cord-006788-kz8i4a6h	181	25	that	that	WDT
cord-006788-kz8i4a6h	181	26	prevent	prevent	VBP
cord-006788-kz8i4a6h	181	27	fatty	fatty	JJ
cord-006788-kz8i4a6h	181	28	degeneration	degeneration	NN
cord-006788-kz8i4a6h	181	29	,	,	,
cord-006788-kz8i4a6h	181	30	gluco	gluco	NN
cord-006788-kz8i4a6h	181	31	-	-	HYPH
cord-006788-kz8i4a6h	181	32	lipotoxicity	lipotoxicity	NN
cord-006788-kz8i4a6h	181	33	,	,	,
cord-006788-kz8i4a6h	181	34	oxidative	oxidative	JJ
cord-006788-kz8i4a6h	181	35	and	and	CC
cord-006788-kz8i4a6h	181	36	ER	ER	NNP
cord-006788-kz8i4a6h	181	37	stress	stress	NN
cord-006788-kz8i4a6h	181	38	,	,	,
cord-006788-kz8i4a6h	181	39	and	and	CC
cord-006788-kz8i4a6h	181	40	inflammatory	inflammatory	JJ
cord-006788-kz8i4a6h	181	41	and	and	CC
cord-006788-kz8i4a6h	181	42	immune	immune	JJ
cord-006788-kz8i4a6h	181	43	cell	cell	NN
cord-006788-kz8i4a6h	181	44	infiltration	infiltration	NN
cord-006788-kz8i4a6h	181	45	.	.	.
cord-006788-kz8i4a6h	182	1	These	these	DT
cord-006788-kz8i4a6h	182	2	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	182	3	activities	activity	NNS
cord-006788-kz8i4a6h	182	4	may	may	MD
cord-006788-kz8i4a6h	182	5	be	be	VB
cord-006788-kz8i4a6h	182	6	mediated	mediate	VBN
cord-006788-kz8i4a6h	182	7	in	in	IN
cord-006788-kz8i4a6h	182	8	part	part	NN
cord-006788-kz8i4a6h	182	9	through	through	IN
cord-006788-kz8i4a6h	182	10	efficient	efficient	JJ
cord-006788-kz8i4a6h	182	11	and	and	CC
cord-006788-kz8i4a6h	182	12	durable	durable	JJ
cord-006788-kz8i4a6h	182	13	systemic	systemic	JJ
cord-006788-kz8i4a6h	182	14	and	and	CC
cord-006788-kz8i4a6h	182	15	local	local	JJ
cord-006788-kz8i4a6h	182	16	glycemic	glycemic	NN
cord-006788-kz8i4a6h	182	17	and	and	CC
cord-006788-kz8i4a6h	182	18	lipidemic	lipidemic	NNP
cord-006788-kz8i4a6h	182	19	control	control	NN
cord-006788-kz8i4a6h	182	20	,	,	,
cord-006788-kz8i4a6h	182	21	improvement	improvement	NN
cord-006788-kz8i4a6h	182	22	of	of	IN
cord-006788-kz8i4a6h	182	23	insulin	insulin	NN
cord-006788-kz8i4a6h	182	24	sensitivity	sensitivity	NN
cord-006788-kz8i4a6h	182	25	,	,	,
cord-006788-kz8i4a6h	182	26	and	and	CC
cord-006788-kz8i4a6h	182	27	promotion	promotion	NN
cord-006788-kz8i4a6h	182	28	of	of	IN
cord-006788-kz8i4a6h	182	29	lipid	lipid	NN
cord-006788-kz8i4a6h	182	30	catabolism	catabolism	NN
cord-006788-kz8i4a6h	182	31	(	(	-LRB-
cord-006788-kz8i4a6h	182	32	lipolysis	lipolysis	NN
cord-006788-kz8i4a6h	182	33	and	and	CC
cord-006788-kz8i4a6h	182	34	fatty	fatty	JJ
cord-006788-kz8i4a6h	182	35	acid	acid	NN
cord-006788-kz8i4a6h	182	36	oxidation	oxidation	NN
cord-006788-kz8i4a6h	182	37	)	)	-RRB-
cord-006788-kz8i4a6h	182	38	,	,	,
cord-006788-kz8i4a6h	182	39	adipose	adipose	JJ
cord-006788-kz8i4a6h	182	40	beigeing	beigeing	NN
cord-006788-kz8i4a6h	182	41	,	,	,
cord-006788-kz8i4a6h	182	42	and	and	CC
cord-006788-kz8i4a6h	182	43	futile	futile	JJ
cord-006788-kz8i4a6h	182	44	energy	energy	NN
cord-006788-kz8i4a6h	182	45	expenditure	expenditure	NN
cord-006788-kz8i4a6h	182	46	in	in	IN
cord-006788-kz8i4a6h	182	47	adipose	adipose	JJ
cord-006788-kz8i4a6h	182	48	tissues	tissue	NNS
cord-006788-kz8i4a6h	182	49	,	,	,
cord-006788-kz8i4a6h	182	50	local	local	JJ
cord-006788-kz8i4a6h	182	51	adipocytes	adipocyte	NNS
cord-006788-kz8i4a6h	182	52	,	,	,
cord-006788-kz8i4a6h	182	53	and	and	CC
cord-006788-kz8i4a6h	182	54	brain	brain	NN
cord-006788-kz8i4a6h	182	55	in	in	IN
cord-006788-kz8i4a6h	182	56	both	both	CC
cord-006788-kz8i4a6h	182	57	UCP1-dependent	UCP1-dependent	NNP
cord-006788-kz8i4a6h	182	58	and	and	CC
cord-006788-kz8i4a6h	182	59	adrenergic	adrenergic	JJ
cord-006788-kz8i4a6h	182	60	sympathetic	sympathetic	JJ
cord-006788-kz8i4a6h	182	61	nervous	nervous	JJ
cord-006788-kz8i4a6h	182	62	system	system	NN
cord-006788-kz8i4a6h	182	63	-	-	HYPH
cord-006788-kz8i4a6h	182	64	dependent	dependent	JJ
cord-006788-kz8i4a6h	182	65	mechanisms	mechanism	NNS
cord-006788-kz8i4a6h	182	66	[	[	-LRB-
cord-006788-kz8i4a6h	182	67	79	79	CD
cord-006788-kz8i4a6h	182	68	,	,	,
cord-006788-kz8i4a6h	182	69	105	105	CD
cord-006788-kz8i4a6h	182	70	,	,	,
cord-006788-kz8i4a6h	182	71	106	106	CD
cord-006788-kz8i4a6h	182	72	,	,	,
cord-006788-kz8i4a6h	182	73	141	141	CD
cord-006788-kz8i4a6h	182	74	,	,	,
cord-006788-kz8i4a6h	182	75	149	149	CD
cord-006788-kz8i4a6h	182	76	,	,	,
cord-006788-kz8i4a6h	182	77	150	150	CD
cord-006788-kz8i4a6h	182	78	]	]	-RRB-
cord-006788-kz8i4a6h	182	79	.	.	.
cord-006788-kz8i4a6h	183	1	As	as	IN
cord-006788-kz8i4a6h	183	2	a	a	DT
cord-006788-kz8i4a6h	183	3	result	result	NN
cord-006788-kz8i4a6h	183	4	,	,	,
cord-006788-kz8i4a6h	183	5	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	183	6	effectively	effectively	RB
cord-006788-kz8i4a6h	183	7	reverses	reverse	VBZ
cord-006788-kz8i4a6h	183	8	hepatic	hepatic	JJ
cord-006788-kz8i4a6h	183	9	steatosis	steatosis	NN
cord-006788-kz8i4a6h	183	10	in	in	IN
cord-006788-kz8i4a6h	183	11	obese	obese	JJ
cord-006788-kz8i4a6h	183	12	mice	mouse	NNS
cord-006788-kz8i4a6h	183	13	and	and	CC
cord-006788-kz8i4a6h	183	14	clinical	clinical	JJ
cord-006788-kz8i4a6h	183	15	obese	obese	JJ
cord-006788-kz8i4a6h	183	16	patients	patient	NNS
cord-006788-kz8i4a6h	183	17	[	[	-LRB-
cord-006788-kz8i4a6h	183	18	73	73	CD
cord-006788-kz8i4a6h	183	19	,	,	,
cord-006788-kz8i4a6h	183	20	105	105	CD
cord-006788-kz8i4a6h	183	21	,	,	,
cord-006788-kz8i4a6h	183	22	151	151	CD
cord-006788-kz8i4a6h	183	23	]	]	-RRB-
cord-006788-kz8i4a6h	183	24	.	.	.
cord-006788-kz8i4a6h	184	1	Furthermore	furthermore	RB
cord-006788-kz8i4a6h	184	2	,	,	,
cord-006788-kz8i4a6h	184	3	the	the	DT
cord-006788-kz8i4a6h	184	4	pharmacological	pharmacological	JJ
cord-006788-kz8i4a6h	184	5	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	184	6	analogs	analog	NNS
cord-006788-kz8i4a6h	184	7	and	and	CC
cord-006788-kz8i4a6h	184	8	FGFR1-KLB	FGFR1-KLB	NNP
cord-006788-kz8i4a6h	184	9	agonists	agonist	NNS
cord-006788-kz8i4a6h	184	10	have	have	VBP
cord-006788-kz8i4a6h	184	11	been	be	VBN
cord-006788-kz8i4a6h	184	12	shown	show	VBN
cord-006788-kz8i4a6h	184	13	to	to	TO
cord-006788-kz8i4a6h	184	14	directly	directly	RB
cord-006788-kz8i4a6h	184	15	improve	improve	VB
cord-006788-kz8i4a6h	184	16	the	the	DT
cord-006788-kz8i4a6h	184	17	spectrum	spectrum	NN
cord-006788-kz8i4a6h	184	18	of	of	IN
cord-006788-kz8i4a6h	184	19	adverse	adverse	JJ
cord-006788-kz8i4a6h	184	20	components	component	NNS
cord-006788-kz8i4a6h	184	21	of	of	IN
cord-006788-kz8i4a6h	184	22	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	184	23	syndrome	syndrome	NN
cord-006788-kz8i4a6h	184	24	,	,	,
cord-006788-kz8i4a6h	184	25	including	include	VBG
cord-006788-kz8i4a6h	184	26	central	central	JJ
cord-006788-kz8i4a6h	184	27	obesity	obesity	NN
cord-006788-kz8i4a6h	184	28	,	,	,
cord-006788-kz8i4a6h	184	29	insulin	insulin	NN
cord-006788-kz8i4a6h	184	30	resistance	resistance	NN
cord-006788-kz8i4a6h	184	31	,	,	,
cord-006788-kz8i4a6h	184	32	fasting	fast	VBG
cord-006788-kz8i4a6h	184	33	hyperglycemia	hyperglycemia	NN
cord-006788-kz8i4a6h	184	34	,	,	,
cord-006788-kz8i4a6h	184	35	dyslipidemia	dyslipidemia	NN
cord-006788-kz8i4a6h	184	36	,	,	,
cord-006788-kz8i4a6h	184	37	systemic	systemic	JJ
cord-006788-kz8i4a6h	184	38	hypertension	hypertension	NN
cord-006788-kz8i4a6h	184	39	,	,	,
cord-006788-kz8i4a6h	184	40	and	and	CC
cord-006788-kz8i4a6h	184	41	fatty	fatty	JJ
cord-006788-kz8i4a6h	184	42	liver	liver	NN
cord-006788-kz8i4a6h	184	43	,	,	,
cord-006788-kz8i4a6h	184	44	which	which	WDT
cord-006788-kz8i4a6h	184	45	are	be	VBP
cord-006788-kz8i4a6h	184	46	the	the	DT
cord-006788-kz8i4a6h	184	47	major	major	JJ
cord-006788-kz8i4a6h	184	48	risk	risk	NN
cord-006788-kz8i4a6h	184	49	factors	factor	NNS
cord-006788-kz8i4a6h	184	50	for	for	IN
cord-006788-kz8i4a6h	184	51	cardiovascular	cardiovascular	JJ
cord-006788-kz8i4a6h	184	52	disease	disease	NN
cord-006788-kz8i4a6h	184	53	(	(	-LRB-
cord-006788-kz8i4a6h	184	54	CVD	CVD	NNP
cord-006788-kz8i4a6h	184	55	)	)	-RRB-
cord-006788-kz8i4a6h	184	56	,	,	,
cord-006788-kz8i4a6h	184	57	type	type	NN
cord-006788-kz8i4a6h	184	58	2	2	CD
cord-006788-kz8i4a6h	184	59	diabetes	diabetes	NN
cord-006788-kz8i4a6h	184	60	mellitus	mellitus	NN
cord-006788-kz8i4a6h	184	61	,	,	,
cord-006788-kz8i4a6h	184	62	chronic	chronic	JJ
cord-006788-kz8i4a6h	184	63	kidney	kidney	NN
cord-006788-kz8i4a6h	184	64	disease	disease	NN
cord-006788-kz8i4a6h	184	65	(	(	-LRB-
cord-006788-kz8i4a6h	184	66	CKD	CKD	NNP
cord-006788-kz8i4a6h	184	67	)	)	-RRB-
cord-006788-kz8i4a6h	184	68	,	,	,
cord-006788-kz8i4a6h	184	69	and	and	CC
cord-006788-kz8i4a6h	184	70	all	all	DT
cord-006788-kz8i4a6h	184	71	-	-	HYPH
cord-006788-kz8i4a6h	184	72	cause	cause	NN
cord-006788-kz8i4a6h	184	73	mortality	mortality	NN
cord-006788-kz8i4a6h	184	74	[	[	-LRB-
cord-006788-kz8i4a6h	184	75	2	2	CD
cord-006788-kz8i4a6h	184	76	,	,	,
cord-006788-kz8i4a6h	184	77	7	7	CD
cord-006788-kz8i4a6h	184	78	,	,	,
cord-006788-kz8i4a6h	184	79	73	73	CD
cord-006788-kz8i4a6h	184	80	,	,	,
cord-006788-kz8i4a6h	184	81	74	74	CD
cord-006788-kz8i4a6h	184	82	,	,	,
cord-006788-kz8i4a6h	184	83	107	107	CD
cord-006788-kz8i4a6h	184	84	]	]	-RRB-
cord-006788-kz8i4a6h	184	85	.	.	.
cord-006788-kz8i4a6h	185	1	The	the	DT
cord-006788-kz8i4a6h	185	2	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	185	3	axes	axis	NNS
cord-006788-kz8i4a6h	185	4	suppress	suppress	VBP
cord-006788-kz8i4a6h	185	5	atherosclerotic	atherosclerotic	JJ
cord-006788-kz8i4a6h	185	6	plaque	plaque	NN
cord-006788-kz8i4a6h	185	7	by	by	IN
cord-006788-kz8i4a6h	185	8	reducing	reduce	VBG
cord-006788-kz8i4a6h	185	9	hypercholesterolemia	hypercholesterolemia	NN
cord-006788-kz8i4a6h	185	10	,	,	,
cord-006788-kz8i4a6h	185	11	oxidative	oxidative	JJ
cord-006788-kz8i4a6h	185	12	stress	stress	NN
cord-006788-kz8i4a6h	185	13	,	,	,
cord-006788-kz8i4a6h	185	14	and	and	CC
cord-006788-kz8i4a6h	185	15	smooth	smooth	JJ
cord-006788-kz8i4a6h	185	16	muscle	muscle	NN
cord-006788-kz8i4a6h	185	17	cell	cell	NN
cord-006788-kz8i4a6h	185	18	proliferation	proliferation	NN
cord-006788-kz8i4a6h	185	19	via	via	IN
cord-006788-kz8i4a6h	185	20	adiponectin	adiponectin	NN
cord-006788-kz8i4a6h	185	21	-	-	HYPH
cord-006788-kz8i4a6h	185	22	dependent	dependent	JJ
cord-006788-kz8i4a6h	185	23	and	and	CC
cord-006788-kz8i4a6h	185	24	adiponectinindependent	adiponectinindependent	NN
cord-006788-kz8i4a6h	185	25	mechanisms	mechanism	NNS
cord-006788-kz8i4a6h	185	26	[	[	-LRB-
cord-006788-kz8i4a6h	185	27	129	129	CD
cord-006788-kz8i4a6h	185	28	]	]	-RRB-
cord-006788-kz8i4a6h	185	29	.	.	.
cord-006788-kz8i4a6h	186	1	FGF21-deficient	fgf21-deficient	CD
cord-006788-kz8i4a6h	186	2	mice	mouse	NNS
cord-006788-kz8i4a6h	186	3	developed	develop	VBD
cord-006788-kz8i4a6h	186	4	significant	significant	JJ
cord-006788-kz8i4a6h	186	5	islet	islet	NN
cord-006788-kz8i4a6h	186	6	hyperplasia	hyperplasia	NN
cord-006788-kz8i4a6h	186	7	and	and	CC
cord-006788-kz8i4a6h	186	8	periductal	periductal	JJ
cord-006788-kz8i4a6h	186	9	lymphocytic	lymphocytic	JJ
cord-006788-kz8i4a6h	186	10	inflammation	inflammation	NN
cord-006788-kz8i4a6h	186	11	upon	upon	IN
cord-006788-kz8i4a6h	186	12	chronic	chronic	JJ
cord-006788-kz8i4a6h	186	13	challenge	challenge	NN
cord-006788-kz8i4a6h	186	14	of	of	IN
cord-006788-kz8i4a6h	186	15	an	an	DT
cord-006788-kz8i4a6h	186	16	obesogenic	obesogenic	JJ
cord-006788-kz8i4a6h	186	17	high	high	JJ
cord-006788-kz8i4a6h	186	18	-	-	HYPH
cord-006788-kz8i4a6h	186	19	fat	fat	NN
cord-006788-kz8i4a6h	186	20	diet	diet	NN
cord-006788-kz8i4a6h	186	21	,	,	,
cord-006788-kz8i4a6h	186	22	indicating	indicate	VBG
cord-006788-kz8i4a6h	186	23	a	a	DT
cord-006788-kz8i4a6h	186	24	protective	protective	JJ
cord-006788-kz8i4a6h	186	25	role	role	NN
cord-006788-kz8i4a6h	186	26	of	of	IN
cord-006788-kz8i4a6h	186	27	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	186	28	in	in	IN
cord-006788-kz8i4a6h	186	29	compensatory	compensatory	JJ
cord-006788-kz8i4a6h	186	30	islet	islet	NN
cord-006788-kz8i4a6h	186	31	hyperplasia	hyperplasia	NN
cord-006788-kz8i4a6h	186	32	and	and	CC
cord-006788-kz8i4a6h	186	33	pancreatic	pancreatic	JJ
cord-006788-kz8i4a6h	186	34	inflammation	inflammation	NN
cord-006788-kz8i4a6h	186	35	associated	associate	VBN
cord-006788-kz8i4a6h	186	36	with	with	IN
cord-006788-kz8i4a6h	186	37	obesity	obesity	NN
cord-006788-kz8i4a6h	186	38	[	[	-LRB-
cord-006788-kz8i4a6h	186	39	117	117	CD
cord-006788-kz8i4a6h	186	40	,	,	,
cord-006788-kz8i4a6h	186	41	152	152	CD
cord-006788-kz8i4a6h	186	42	]	]	-RRB-
cord-006788-kz8i4a6h	186	43	.	.	.
cord-006788-kz8i4a6h	187	1	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	187	2	directly	directly	RB
cord-006788-kz8i4a6h	187	3	suppresses	suppress	VBZ
cord-006788-kz8i4a6h	187	4	triglyceride	triglyceride	NN
cord-006788-kz8i4a6h	187	5	levels	level	NNS
cord-006788-kz8i4a6h	187	6	and	and	CC
cord-006788-kz8i4a6h	187	7	lipid	lipid	NN
cord-006788-kz8i4a6h	187	8	accumulation	accumulation	NN
cord-006788-kz8i4a6h	187	9	in	in	IN
cord-006788-kz8i4a6h	187	10	kidney	kidney	NN
cord-006788-kz8i4a6h	187	11	tissues	tissue	NNS
cord-006788-kz8i4a6h	187	12	,	,	,
cord-006788-kz8i4a6h	187	13	thereby	thereby	RB
cord-006788-kz8i4a6h	187	14	reducing	reduce	VBG
cord-006788-kz8i4a6h	187	15	lipotoxicity	lipotoxicity	NN
cord-006788-kz8i4a6h	187	16	,	,	,
cord-006788-kz8i4a6h	187	17	oxidative	oxidative	JJ
cord-006788-kz8i4a6h	187	18	stress	stress	NN
cord-006788-kz8i4a6h	187	19	,	,	,
cord-006788-kz8i4a6h	187	20	inflammation	inflammation	NN
cord-006788-kz8i4a6h	187	21	,	,	,
cord-006788-kz8i4a6h	187	22	glomerular	glomerular	JJ
cord-006788-kz8i4a6h	187	23	abnormalities	abnormality	NNS
cord-006788-kz8i4a6h	187	24	,	,	,
cord-006788-kz8i4a6h	187	25	fibrotic	fibrotic	JJ
cord-006788-kz8i4a6h	187	26	renal	renal	JJ
cord-006788-kz8i4a6h	187	27	injury	injury	NN
cord-006788-kz8i4a6h	187	28	in	in	IN
cord-006788-kz8i4a6h	187	29	diabetic	diabetic	JJ
cord-006788-kz8i4a6h	187	30	nephropathy	nephropathy	NN
cord-006788-kz8i4a6h	187	31	,	,	,
cord-006788-kz8i4a6h	187	32	while	while	IN
cord-006788-kz8i4a6h	187	33	deficiency	deficiency	NN
cord-006788-kz8i4a6h	187	34	of	of	IN
cord-006788-kz8i4a6h	187	35	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	187	36	aggravates	aggravate	VBZ
cord-006788-kz8i4a6h	187	37	these	these	DT
cord-006788-kz8i4a6h	187	38	conditions	condition	NNS
cord-006788-kz8i4a6h	187	39	[	[	-LRB-
cord-006788-kz8i4a6h	187	40	153	153	CD
cord-006788-kz8i4a6h	187	41	,	,	,
cord-006788-kz8i4a6h	187	42	154	154	CD
cord-006788-kz8i4a6h	187	43	]	]	-RRB-
cord-006788-kz8i4a6h	187	44	,	,	,
cord-006788-kz8i4a6h	187	45	indicating	indicate	VBG
cord-006788-kz8i4a6h	187	46	a	a	DT
cord-006788-kz8i4a6h	187	47	defensive	defensive	JJ
cord-006788-kz8i4a6h	187	48	role	role	NN
cord-006788-kz8i4a6h	187	49	of	of	IN
cord-006788-kz8i4a6h	187	50	FGF21	fgf21	NN
cord-006788-kz8i4a6h	187	51	against	against	IN
cord-006788-kz8i4a6h	187	52	kidney	kidney	NN
cord-006788-kz8i4a6h	187	53	pathogenesis	pathogenesis	NN
cord-006788-kz8i4a6h	187	54	associated	associate	VBN
cord-006788-kz8i4a6h	187	55	with	with	IN
cord-006788-kz8i4a6h	187	56	obesity	obesity	NN
cord-006788-kz8i4a6h	187	57	and	and	CC
cord-006788-kz8i4a6h	187	58	diabetes	diabetes	NN
cord-006788-kz8i4a6h	187	59	.	.	.
cord-006788-kz8i4a6h	188	1	The	the	DT
cord-006788-kz8i4a6h	188	2	anti	anti	JJ
cord-006788-kz8i4a6h	188	3	-	-	JJ
cord-006788-kz8i4a6h	188	4	stress	stress	JJ
cord-006788-kz8i4a6h	188	5	and	and	CC
cord-006788-kz8i4a6h	188	6	anti	anti	JJ
cord-006788-kz8i4a6h	188	7	-	-	JJ
cord-006788-kz8i4a6h	188	8	inflammatory	inflammatory	JJ
cord-006788-kz8i4a6h	188	9	effects	effect	NNS
cord-006788-kz8i4a6h	188	10	of	of	IN
cord-006788-kz8i4a6h	188	11	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	188	12	may	may	MD
cord-006788-kz8i4a6h	188	13	be	be	VB
cord-006788-kz8i4a6h	188	14	also	also	RB
cord-006788-kz8i4a6h	188	15	attributable	attributable	JJ
cord-006788-kz8i4a6h	188	16	to	to	IN
cord-006788-kz8i4a6h	188	17	its	-PRON-	PRP$
cord-006788-kz8i4a6h	188	18	direct	direct	JJ
cord-006788-kz8i4a6h	188	19	action	action	NN
cord-006788-kz8i4a6h	188	20	on	on	IN
cord-006788-kz8i4a6h	188	21	nonmetabolic	nonmetabolic	NNP
cord-006788-kz8i4a6h	188	22	cells	cell	NNS
cord-006788-kz8i4a6h	188	23	and	and	CC
cord-006788-kz8i4a6h	188	24	non	non	JJ
cord-006788-kz8i4a6h	188	25	-	-	JJ
cord-006788-kz8i4a6h	188	26	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	188	27	activities	activity	NNS
cord-006788-kz8i4a6h	188	28	.	.	.
cord-006788-kz8i4a6h	189	1	FGF21	FGF21	NNS
cord-006788-kz8i4a6h	189	2	directly	directly	RB
cord-006788-kz8i4a6h	189	3	inhibits	inhibit	VBZ
cord-006788-kz8i4a6h	189	4	cardiomyocyte	cardiomyocyte	NN
cord-006788-kz8i4a6h	189	5	apoptosis	apoptosis	NN
cord-006788-kz8i4a6h	189	6	,	,	,
cord-006788-kz8i4a6h	189	7	oxidative	oxidative	JJ
cord-006788-kz8i4a6h	189	8	stress	stress	NN
cord-006788-kz8i4a6h	189	9	,	,	,
cord-006788-kz8i4a6h	189	10	myocardial	myocardial	JJ
cord-006788-kz8i4a6h	189	11	injury	injury	NN
cord-006788-kz8i4a6h	189	12	,	,	,
cord-006788-kz8i4a6h	189	13	thereby	thereby	RB
cord-006788-kz8i4a6h	189	14	reducing	reduce	VBG
cord-006788-kz8i4a6h	189	15	the	the	DT
cord-006788-kz8i4a6h	189	16	risk	risk	NN
cord-006788-kz8i4a6h	189	17	of	of	IN
cord-006788-kz8i4a6h	189	18	pathological	pathological	JJ
cord-006788-kz8i4a6h	189	19	cardiac	cardiac	JJ
cord-006788-kz8i4a6h	189	20	remodeling	remodeling	NN
cord-006788-kz8i4a6h	189	21	and	and	CC
cord-006788-kz8i4a6h	189	22	dysfunction	dysfunction	NN
cord-006788-kz8i4a6h	189	23	,	,	,
cord-006788-kz8i4a6h	189	24	cardiac	cardiac	JJ
cord-006788-kz8i4a6h	189	25	hypertrophy	hypertrophy	NN
cord-006788-kz8i4a6h	189	26	,	,	,
cord-006788-kz8i4a6h	189	27	myocardial	myocardial	JJ
cord-006788-kz8i4a6h	189	28	ischemia	ischemia	NN
cord-006788-kz8i4a6h	189	29	,	,	,
cord-006788-kz8i4a6h	189	30	and	and	CC
cord-006788-kz8i4a6h	189	31	heart	heart	NN
cord-006788-kz8i4a6h	189	32	failure	failure	NN
cord-006788-kz8i4a6h	189	33	in	in	IN
cord-006788-kz8i4a6h	189	34	ischemic	ischemic	JJ
cord-006788-kz8i4a6h	189	35	heart	heart	NN
cord-006788-kz8i4a6h	189	36	tissue	tissue	NN
cord-006788-kz8i4a6h	189	37	and	and	CC
cord-006788-kz8i4a6h	189	38	diabetic	diabetic	JJ
cord-006788-kz8i4a6h	189	39	cardiomyopathy	cardiomyopathy	NN
cord-006788-kz8i4a6h	189	40	[	[	-LRB-
cord-006788-kz8i4a6h	189	41	130	130	CD
cord-006788-kz8i4a6h	189	42	,	,	,
cord-006788-kz8i4a6h	189	43	155	155	CD
cord-006788-kz8i4a6h	189	44	]	]	-RRB-
cord-006788-kz8i4a6h	189	45	.	.	.
cord-006788-kz8i4a6h	190	1	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	190	2	protects	protect	VBZ
cord-006788-kz8i4a6h	190	3	the	the	DT
cord-006788-kz8i4a6h	190	4	pancreas	pancrea	NNS
cord-006788-kz8i4a6h	190	5	from	from	IN
cord-006788-kz8i4a6h	190	6	caerulein	caerulein	JJ
cord-006788-kz8i4a6h	190	7	-	-	:
cord-006788-kz8i4a6h	190	8	and	and	CC
cord-006788-kz8i4a6h	190	9	Larginine	Larginine	NNP
cord-006788-kz8i4a6h	190	10	-	-	HYPH
cord-006788-kz8i4a6h	190	11	induced	induce	VBN
cord-006788-kz8i4a6h	190	12	pancreatitis	pancreatitis	NN
cord-006788-kz8i4a6h	190	13	,	,	,
cord-006788-kz8i4a6h	190	14	acinar	acinar	NNP
cord-006788-kz8i4a6h	190	15	cell	cell	NN
cord-006788-kz8i4a6h	190	16	injury	injury	NN
cord-006788-kz8i4a6h	190	17	,	,	,
cord-006788-kz8i4a6h	190	18	and	and	CC
cord-006788-kz8i4a6h	190	19	fibrosis	fibrosis	NN
cord-006788-kz8i4a6h	190	20	in	in	IN
cord-006788-kz8i4a6h	190	21	mice	mouse	NNS
cord-006788-kz8i4a6h	190	22	[	[	-LRB-
cord-006788-kz8i4a6h	190	23	118	118	CD
cord-006788-kz8i4a6h	190	24	,	,	,
cord-006788-kz8i4a6h	190	25	119	119	CD
cord-006788-kz8i4a6h	190	26	,	,	,
cord-006788-kz8i4a6h	190	27	156	156	CD
cord-006788-kz8i4a6h	190	28	]	]	-RRB-
cord-006788-kz8i4a6h	190	29	.	.	.
cord-006788-kz8i4a6h	191	1	FGF21	fgf21	NN
cord-006788-kz8i4a6h	191	2	acts	act	NNS
cord-006788-kz8i4a6h	191	3	directly	directly	RB
cord-006788-kz8i4a6h	191	4	on	on	IN
cord-006788-kz8i4a6h	191	5	renal	renal	JJ
cord-006788-kz8i4a6h	191	6	mesangial	mesangial	JJ
cord-006788-kz8i4a6h	191	7	cells	cell	NNS
cord-006788-kz8i4a6h	191	8	to	to	TO
cord-006788-kz8i4a6h	191	9	reduce	reduce	VB
cord-006788-kz8i4a6h	191	10	glucose	glucose	NN
cord-006788-kz8i4a6h	191	11	reabsorption	reabsorption	NN
cord-006788-kz8i4a6h	191	12	and	and	CC
cord-006788-kz8i4a6h	191	13	prevent	prevent	VB
cord-006788-kz8i4a6h	191	14	hyperglycemia	hyperglycemia	NN
cord-006788-kz8i4a6h	191	15	-	-	HYPH
cord-006788-kz8i4a6h	191	16	induced	induce	VBN
cord-006788-kz8i4a6h	191	17	fibrogenesis	fibrogenesis	NN
cord-006788-kz8i4a6h	191	18	in	in	IN
cord-006788-kz8i4a6h	191	19	db	db	NNP
cord-006788-kz8i4a6h	191	20	/	/	SYM
cord-006788-kz8i4a6h	191	21	db	db	NNP
cord-006788-kz8i4a6h	191	22	mice	mouse	NNS
cord-006788-kz8i4a6h	191	23	[	[	-LRB-
cord-006788-kz8i4a6h	191	24	157	157	CD
cord-006788-kz8i4a6h	191	25	,	,	,
cord-006788-kz8i4a6h	191	26	158	158	CD
cord-006788-kz8i4a6h	191	27	]	]	-RRB-
cord-006788-kz8i4a6h	191	28	.	.	.
cord-006788-kz8i4a6h	192	1	Interestingly	interestingly	RB
cord-006788-kz8i4a6h	192	2	,	,	,
cord-006788-kz8i4a6h	192	3	recent	recent	JJ
cord-006788-kz8i4a6h	192	4	evidence	evidence	NN
cord-006788-kz8i4a6h	192	5	supports	support	VBZ
cord-006788-kz8i4a6h	192	6	that	that	IN
cord-006788-kz8i4a6h	192	7	FGF21	fgf21	NN
cord-006788-kz8i4a6h	192	8	can	can	MD
cord-006788-kz8i4a6h	192	9	directly	directly	RB
cord-006788-kz8i4a6h	192	10	act	act	VB
cord-006788-kz8i4a6h	192	11	on	on	IN
cord-006788-kz8i4a6h	192	12	inflammatory	inflammatory	JJ
cord-006788-kz8i4a6h	192	13	and	and	CC
cord-006788-kz8i4a6h	192	14	immune	immune	JJ
cord-006788-kz8i4a6h	192	15	cells	cell	NNS
cord-006788-kz8i4a6h	192	16	to	to	TO
cord-006788-kz8i4a6h	192	17	attenuate	attenuate	VB
cord-006788-kz8i4a6h	192	18	inflammation	inflammation	NN
cord-006788-kz8i4a6h	192	19	and	and	CC
cord-006788-kz8i4a6h	192	20	inflammatory	inflammatory	JJ
cord-006788-kz8i4a6h	192	21	damage	damage	NN
cord-006788-kz8i4a6h	192	22	.	.	.
cord-006788-kz8i4a6h	193	1	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	193	2	activates	activate	VBZ
cord-006788-kz8i4a6h	193	3	THP-1-derived	thp-1-derived	JJ
cord-006788-kz8i4a6h	193	4	macrophages	macrophage	NNS
cord-006788-kz8i4a6h	193	5	to	to	TO
cord-006788-kz8i4a6h	193	6	promote	promote	VB
cord-006788-kz8i4a6h	193	7	cholesterol	cholesterol	NN
cord-006788-kz8i4a6h	193	8	efflux	efflux	NN
cord-006788-kz8i4a6h	193	9	,	,	,
cord-006788-kz8i4a6h	193	10	oxidized	oxidize	VBN
cord-006788-kz8i4a6h	193	11	low	low	JJ
cord-006788-kz8i4a6h	193	12	-	-	HYPH
cord-006788-kz8i4a6h	193	13	density	density	NN
cord-006788-kz8i4a6h	193	14	lipoprotein	lipoprotein	NN
cord-006788-kz8i4a6h	193	15	(	(	-LRB-
cord-006788-kz8i4a6h	193	16	oxLDL	oxldl	JJ
cord-006788-kz8i4a6h	193	17	)	)	-RRB-
cord-006788-kz8i4a6h	193	18	uptake	uptake	NN
cord-006788-kz8i4a6h	193	19	,	,	,
cord-006788-kz8i4a6h	193	20	and	and	CC
cord-006788-kz8i4a6h	193	21	foam	foam	NN
cord-006788-kz8i4a6h	193	22	cell	cell	NN
cord-006788-kz8i4a6h	193	23	formation	formation	NN
cord-006788-kz8i4a6h	193	24	and	and	CC
cord-006788-kz8i4a6h	193	25	inhibits	inhibit	VBZ
cord-006788-kz8i4a6h	193	26	macrophage	macrophage	NN
cord-006788-kz8i4a6h	193	27	inflammatory	inflammatory	JJ
cord-006788-kz8i4a6h	193	28	capacity	capacity	NN
cord-006788-kz8i4a6h	193	29	through	through	IN
cord-006788-kz8i4a6h	193	30	the	the	DT
cord-006788-kz8i4a6h	193	31	Nrf2	Nrf2	NNP
cord-006788-kz8i4a6h	193	32	pathway	pathway	NN
cord-006788-kz8i4a6h	193	33	[	[	-LRB-
cord-006788-kz8i4a6h	193	34	156	156	CD
cord-006788-kz8i4a6h	193	35	,	,	,
cord-006788-kz8i4a6h	193	36	159	159	CD
cord-006788-kz8i4a6h	193	37	,	,	,
cord-006788-kz8i4a6h	193	38	160	160	CD
cord-006788-kz8i4a6h	193	39	]	]	-RRB-
cord-006788-kz8i4a6h	193	40	.	.	.
cord-006788-kz8i4a6h	194	1	Adipose	adipose	JJ
cord-006788-kz8i4a6h	194	2	tissue	tissue	NN
cord-006788-kz8i4a6h	194	3	is	be	VBZ
cord-006788-kz8i4a6h	194	4	an	an	DT
cord-006788-kz8i4a6h	194	5	endocrine	endocrine	JJ
cord-006788-kz8i4a6h	194	6	organ	organ	NN
cord-006788-kz8i4a6h	194	7	and	and	CC
cord-006788-kz8i4a6h	194	8	plays	play	VBZ
cord-006788-kz8i4a6h	194	9	an	an	DT
cord-006788-kz8i4a6h	194	10	active	active	JJ
cord-006788-kz8i4a6h	194	11	role	role	NN
cord-006788-kz8i4a6h	194	12	in	in	IN
cord-006788-kz8i4a6h	194	13	the	the	DT
cord-006788-kz8i4a6h	194	14	inflammation	inflammation	NN
cord-006788-kz8i4a6h	194	15	in	in	IN
cord-006788-kz8i4a6h	194	16	obesity	obesity	NN
cord-006788-kz8i4a6h	194	17	that	that	WDT
cord-006788-kz8i4a6h	194	18	can	can	MD
cord-006788-kz8i4a6h	194	19	favor	favor	VB
cord-006788-kz8i4a6h	194	20	CVD	CVD	NNP
cord-006788-kz8i4a6h	194	21	and	and	CC
cord-006788-kz8i4a6h	194	22	CKD	CKD	NNP
cord-006788-kz8i4a6h	194	23	progression	progression	NN
cord-006788-kz8i4a6h	194	24	by	by	IN
cord-006788-kz8i4a6h	194	25	inducing	induce	VBG
cord-006788-kz8i4a6h	194	26	a	a	DT
cord-006788-kz8i4a6h	194	27	chronic	chronic	JJ
cord-006788-kz8i4a6h	194	28	and	and	CC
cord-006788-kz8i4a6h	194	29	low	low	JJ
cord-006788-kz8i4a6h	194	30	-	-	HYPH
cord-006788-kz8i4a6h	194	31	grade	grade	NN
cord-006788-kz8i4a6h	194	32	inflammation	inflammation	NN
cord-006788-kz8i4a6h	194	33	via	via	IN
cord-006788-kz8i4a6h	194	34	secreted	secrete	VBN
cord-006788-kz8i4a6h	194	35	proinflammatory	proinflammatory	JJ
cord-006788-kz8i4a6h	194	36	adipokines	adipokine	NNS
cord-006788-kz8i4a6h	194	37	and	and	CC
cord-006788-kz8i4a6h	194	38	cytokines	cytokine	NNS
cord-006788-kz8i4a6h	194	39	.	.	.
cord-006788-kz8i4a6h	195	1	Studies	study	NNS
cord-006788-kz8i4a6h	195	2	in	in	IN
cord-006788-kz8i4a6h	195	3	diet	diet	NN
cord-006788-kz8i4a6h	195	4	-	-	HYPH
cord-006788-kz8i4a6h	195	5	induced	induce	VBN
cord-006788-kz8i4a6h	195	6	obesity	obesity	NN
cord-006788-kz8i4a6h	195	7	and	and	CC
cord-006788-kz8i4a6h	195	8	pancreatitis	pancreatitis	NN
cord-006788-kz8i4a6h	195	9	models	model	NNS
cord-006788-kz8i4a6h	195	10	indicate	indicate	VBP
cord-006788-kz8i4a6h	195	11	that	that	IN
cord-006788-kz8i4a6h	195	12	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	195	13	promotes	promote	VBZ
cord-006788-kz8i4a6h	195	14	anti	anti	JJ
cord-006788-kz8i4a6h	195	15	-	-	JJ
cord-006788-kz8i4a6h	195	16	inflammatory	inflammatory	JJ
cord-006788-kz8i4a6h	195	17	macrophage	macrophage	NN
cord-006788-kz8i4a6h	195	18	polarization	polarization	NN
cord-006788-kz8i4a6h	195	19	in	in	IN
cord-006788-kz8i4a6h	195	20	adipose	adipose	JJ
cord-006788-kz8i4a6h	195	21	depots	depot	NNS
cord-006788-kz8i4a6h	195	22	and	and	CC
cord-006788-kz8i4a6h	195	23	pancreas	pancrea	NNS
cord-006788-kz8i4a6h	195	24	,	,	,
cord-006788-kz8i4a6h	195	25	WAT	WAT	NNP
cord-006788-kz8i4a6h	195	26	browning	browning	NNP
cord-006788-kz8i4a6h	195	27	,	,	,
cord-006788-kz8i4a6h	195	28	and	and	CC
cord-006788-kz8i4a6h	195	29	insulin	insulin	NN
cord-006788-kz8i4a6h	195	30	sensitivity	sensitivity	NN
cord-006788-kz8i4a6h	195	31	,	,	,
cord-006788-kz8i4a6h	195	32	thereby	thereby	RB
cord-006788-kz8i4a6h	195	33	effectively	effectively	RB
cord-006788-kz8i4a6h	195	34	preventing	prevent	VBG
cord-006788-kz8i4a6h	195	35	adipose	adipose	JJ
cord-006788-kz8i4a6h	195	36	tissues	tissue	NNS
cord-006788-kz8i4a6h	195	37	from	from	IN
cord-006788-kz8i4a6h	195	38	adapting	adapt	VBG
cord-006788-kz8i4a6h	195	39	proinflammatory	proinflammatory	JJ
cord-006788-kz8i4a6h	195	40	profiles	profile	NNS
cord-006788-kz8i4a6h	195	41	and	and	CC
cord-006788-kz8i4a6h	195	42	the	the	DT
cord-006788-kz8i4a6h	195	43	pancreas	pancrea	NNS
cord-006788-kz8i4a6h	195	44	from	from	IN
cord-006788-kz8i4a6h	195	45	inflammatory	inflammatory	JJ
cord-006788-kz8i4a6h	195	46	fibrosis	fibrosis	NN
cord-006788-kz8i4a6h	195	47	[	[	-LRB-
cord-006788-kz8i4a6h	195	48	109	109	CD
cord-006788-kz8i4a6h	195	49	,	,	,
cord-006788-kz8i4a6h	195	50	156	156	CD
cord-006788-kz8i4a6h	195	51	,	,	,
cord-006788-kz8i4a6h	195	52	159	159	CD
cord-006788-kz8i4a6h	195	53	,	,	,
cord-006788-kz8i4a6h	195	54	161	161	CD
cord-006788-kz8i4a6h	195	55	]	]	-RRB-
cord-006788-kz8i4a6h	195	56	.	.	.
cord-006788-kz8i4a6h	196	1	Interestingly	interestingly	RB
cord-006788-kz8i4a6h	196	2	,	,	,
cord-006788-kz8i4a6h	196	3	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	196	4	was	be	VBD
cord-006788-kz8i4a6h	196	5	found	find	VBN
cord-006788-kz8i4a6h	196	6	highly	highly	RB
cord-006788-kz8i4a6h	196	7	expressed	express	VBN
cord-006788-kz8i4a6h	196	8	in	in	IN
cord-006788-kz8i4a6h	196	9	neutrophils	neutrophil	NNS
cord-006788-kz8i4a6h	196	10	and	and	CC
cord-006788-kz8i4a6h	196	11	monocytes	monocyte	NNS
cord-006788-kz8i4a6h	196	12	among	among	IN
cord-006788-kz8i4a6h	196	13	circulating	circulate	VBG
cord-006788-kz8i4a6h	196	14	leukocytes	leukocyte	NNS
cord-006788-kz8i4a6h	196	15	and	and	CC
cord-006788-kz8i4a6h	196	16	stimulates	stimulate	VBZ
cord-006788-kz8i4a6h	196	17	phagocytosis	phagocytosis	NN
cord-006788-kz8i4a6h	196	18	,	,	,
cord-006788-kz8i4a6h	196	19	glucose	glucose	NN
cord-006788-kz8i4a6h	196	20	uptake	uptake	NN
cord-006788-kz8i4a6h	196	21	,	,	,
cord-006788-kz8i4a6h	196	22	and	and	CC
cord-006788-kz8i4a6h	196	23	reactive	reactive	JJ
cord-006788-kz8i4a6h	196	24	oxygen	oxygen	NN
cord-006788-kz8i4a6h	196	25	species	species	NN
cord-006788-kz8i4a6h	196	26	production	production	NN
cord-006788-kz8i4a6h	196	27	in	in	IN
cord-006788-kz8i4a6h	196	28	a	a	DT
cord-006788-kz8i4a6h	196	29	NADPH	NADPH	NNP
cord-006788-kz8i4a6h	196	30	oxidase	oxidase	NN
cord-006788-kz8i4a6h	196	31	-	-	HYPH
cord-006788-kz8i4a6h	196	32	dependent	dependent	JJ
cord-006788-kz8i4a6h	196	33	manner	manner	NN
cord-006788-kz8i4a6h	196	34	in	in	IN
cord-006788-kz8i4a6h	196	35	the	the	DT
cord-006788-kz8i4a6h	196	36	neutrophil	neutrophil	NN
cord-006788-kz8i4a6h	196	37	-	-	HYPH
cord-006788-kz8i4a6h	196	38	like	like	IN
cord-006788-kz8i4a6h	196	39	HL-60	HL-60	NNP
cord-006788-kz8i4a6h	196	40	and	and	CC
cord-006788-kz8i4a6h	196	41	monocytic	monocytic	NNP
cord-006788-kz8i4a6h	196	42	THP-1	THP-1	NNP
cord-006788-kz8i4a6h	196	43	cells	cell	NNS
cord-006788-kz8i4a6h	196	44	[	[	-LRB-
cord-006788-kz8i4a6h	196	45	162	162	CD
cord-006788-kz8i4a6h	196	46	]	]	-RRB-
cord-006788-kz8i4a6h	196	47	[	[	-LRB-
cord-006788-kz8i4a6h	196	48	163	163	CD
cord-006788-kz8i4a6h	196	49	]	]	-RRB-
cord-006788-kz8i4a6h	196	50	[	[	-LRB-
cord-006788-kz8i4a6h	196	51	164	164	CD
cord-006788-kz8i4a6h	196	52	]	]	-RRB-
cord-006788-kz8i4a6h	196	53	.	.	.
cord-006788-kz8i4a6h	197	1	In	in	IN
cord-006788-kz8i4a6h	197	2	the	the	DT
cord-006788-kz8i4a6h	197	3	type	type	NN
cord-006788-kz8i4a6h	197	4	II	ii	CD
cord-006788-kz8i4a6h	197	5	collagen	collagen	NN
cord-006788-kz8i4a6h	197	6	-	-	HYPH
cord-006788-kz8i4a6h	197	7	induced	induce	VBN
cord-006788-kz8i4a6h	197	8	arthritis	arthritis	NN
cord-006788-kz8i4a6h	197	9	mouse	mouse	NN
cord-006788-kz8i4a6h	197	10	model	model	NN
cord-006788-kz8i4a6h	197	11	,	,	,
cord-006788-kz8i4a6h	197	12	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	197	13	acts	act	NNS
cord-006788-kz8i4a6h	197	14	on	on	IN
cord-006788-kz8i4a6h	197	15	the	the	DT
cord-006788-kz8i4a6h	197	16	spleen	spleen	NN
cord-006788-kz8i4a6h	197	17	to	to	TO
cord-006788-kz8i4a6h	197	18	reduce	reduce	VB
cord-006788-kz8i4a6h	197	19	inflammatory	inflammatory	JJ
cord-006788-kz8i4a6h	197	20	IL-17	IL-17	NNP
cord-006788-kz8i4a6h	197	21	,	,	,
cord-006788-kz8i4a6h	197	22	TNF	TNF	NNP
cord-006788-kz8i4a6h	197	23	-	-	HYPH
cord-006788-kz8i4a6h	197	24	α	α	NNP
cord-006788-kz8i4a6h	197	25	,	,	,
cord-006788-kz8i4a6h	197	26	IL-1β	IL-1β	NNP
cord-006788-kz8i4a6h	197	27	,	,	,
cord-006788-kz8i4a6h	197	28	IL-6	IL-6	NNP
cord-006788-kz8i4a6h	197	29	,	,	,
cord-006788-kz8i4a6h	197	30	IL-8	IL-8	NNP
cord-006788-kz8i4a6h	197	31	,	,	,
cord-006788-kz8i4a6h	197	32	and	and	CC
cord-006788-kz8i4a6h	197	33	MMP3	MMP3	NNP
cord-006788-kz8i4a6h	197	34	and	and	CC
cord-006788-kz8i4a6h	197	35	the	the	DT
cord-006788-kz8i4a6h	197	36	number	number	NN
cord-006788-kz8i4a6h	197	37	of	of	IN
cord-006788-kz8i4a6h	197	38	splenic	splenic	JJ
cord-006788-kz8i4a6h	197	39	TH17	TH17	NNP
cord-006788-kz8i4a6h	197	40	cells	cell	NNS
cord-006788-kz8i4a6h	197	41	,	,	,
cord-006788-kz8i4a6h	197	42	thereby	thereby	RB
cord-006788-kz8i4a6h	197	43	alleviating	alleviate	VBG
cord-006788-kz8i4a6h	197	44	arthritis	arthritis	NN
cord-006788-kz8i4a6h	197	45	severity	severity	NN
cord-006788-kz8i4a6h	197	46	[	[	-LRB-
cord-006788-kz8i4a6h	197	47	165	165	CD
cord-006788-kz8i4a6h	197	48	]	]	-RRB-
cord-006788-kz8i4a6h	197	49	.	.	.
cord-006788-kz8i4a6h	198	1	These	these	DT
cord-006788-kz8i4a6h	198	2	studies	study	NNS
cord-006788-kz8i4a6h	198	3	highlight	highlight	VBP
cord-006788-kz8i4a6h	198	4	the	the	DT
cord-006788-kz8i4a6h	198	5	potential	potential	JJ
cord-006788-kz8i4a6h	198	6	mediator	mediator	NN
cord-006788-kz8i4a6h	198	7	role	role	NN
cord-006788-kz8i4a6h	198	8	of	of	IN
cord-006788-kz8i4a6h	198	9	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	198	10	in	in	IN
cord-006788-kz8i4a6h	198	11	innate	innate	JJ
cord-006788-kz8i4a6h	198	12	immunity	immunity	NN
cord-006788-kz8i4a6h	198	13	and	and	CC
cord-006788-kz8i4a6h	198	14	inflammatory	inflammatory	JJ
cord-006788-kz8i4a6h	198	15	disorders	disorder	NNS
cord-006788-kz8i4a6h	198	16	.	.	.
cord-006788-kz8i4a6h	199	1	The	the	DT
cord-006788-kz8i4a6h	199	2	direct	direct	JJ
cord-006788-kz8i4a6h	199	3	impact	impact	NN
cord-006788-kz8i4a6h	199	4	of	of	IN
cord-006788-kz8i4a6h	199	5	FGF21	fgf21	NN
cord-006788-kz8i4a6h	199	6	on	on	IN
cord-006788-kz8i4a6h	199	7	the	the	DT
cord-006788-kz8i4a6h	199	8	function	function	NN
cord-006788-kz8i4a6h	199	9	of	of	IN
cord-006788-kz8i4a6h	199	10	inflammatory	inflammatory	JJ
cord-006788-kz8i4a6h	199	11	and	and	CC
cord-006788-kz8i4a6h	199	12	immune	immune	JJ
cord-006788-kz8i4a6h	199	13	cells	cell	NNS
cord-006788-kz8i4a6h	199	14	and	and	CC
cord-006788-kz8i4a6h	199	15	associated	associate	VBD
cord-006788-kz8i4a6h	199	16	health	health	NN
cord-006788-kz8i4a6h	199	17	consequences	consequence	NNS
cord-006788-kz8i4a6h	199	18	is	be	VBZ
cord-006788-kz8i4a6h	199	19	yet	yet	RB
cord-006788-kz8i4a6h	199	20	to	to	TO
cord-006788-kz8i4a6h	199	21	be	be	VB
cord-006788-kz8i4a6h	199	22	validated	validate	VBN
cord-006788-kz8i4a6h	199	23	.	.	.
cord-006788-kz8i4a6h	200	1	FGF23	fgf23	NN
cord-006788-kz8i4a6h	200	2	is	be	VBZ
cord-006788-kz8i4a6h	200	3	a	a	DT
cord-006788-kz8i4a6h	200	4	key	key	JJ
cord-006788-kz8i4a6h	200	5	hormonal	hormonal	JJ
cord-006788-kz8i4a6h	200	6	regulator	regulator	NN
cord-006788-kz8i4a6h	200	7	of	of	IN
cord-006788-kz8i4a6h	200	8	phosphate	phosphate	NN
cord-006788-kz8i4a6h	200	9	,	,	,
cord-006788-kz8i4a6h	200	10	vitamin	vitamin	NN
cord-006788-kz8i4a6h	200	11	D	d	NN
cord-006788-kz8i4a6h	200	12	,	,	,
cord-006788-kz8i4a6h	200	13	and	and	CC
cord-006788-kz8i4a6h	200	14	calcium	calcium	NN
cord-006788-kz8i4a6h	200	15	metabolism	metabolism	NN
cord-006788-kz8i4a6h	200	16	,	,	,
cord-006788-kz8i4a6h	200	17	and	and	CC
cord-006788-kz8i4a6h	200	18	its	-PRON-	PRP$
cord-006788-kz8i4a6h	200	19	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	200	20	axes	axis	NNS
cord-006788-kz8i4a6h	200	21	drive	drive	VBP
cord-006788-kz8i4a6h	200	22	a	a	DT
cord-006788-kz8i4a6h	200	23	complex	complex	JJ
cord-006788-kz8i4a6h	200	24	interorgan	interorgan	NN
cord-006788-kz8i4a6h	200	25	crosstalk	crosstalk	NN
cord-006788-kz8i4a6h	200	26	network	network	NN
cord-006788-kz8i4a6h	200	27	for	for	IN
cord-006788-kz8i4a6h	200	28	bone	bone	NN
cord-006788-kz8i4a6h	200	29	health	health	NN
cord-006788-kz8i4a6h	200	30	and	and	CC
cord-006788-kz8i4a6h	200	31	systemic	systemic	JJ
cord-006788-kz8i4a6h	200	32	mineral	mineral	NN
cord-006788-kz8i4a6h	200	33	balance	balance	NN
cord-006788-kz8i4a6h	201	1	(	(	-LRB-
cord-006788-kz8i4a6h	201	2	Fig	Fig	NNP
cord-006788-kz8i4a6h	201	3	.	.	NNP
cord-006788-kz8i4a6h	201	4	4	4	LS
cord-006788-kz8i4a6h	201	5	)	)	-RRB-
cord-006788-kz8i4a6h	201	6	[	[	-LRB-
cord-006788-kz8i4a6h	201	7	2	2	CD
cord-006788-kz8i4a6h	201	8	,	,	,
cord-006788-kz8i4a6h	201	9	61	61	CD
cord-006788-kz8i4a6h	201	10	,	,	,
cord-006788-kz8i4a6h	201	11	[	[	-LRB-
cord-006788-kz8i4a6h	201	12	166	166	CD
cord-006788-kz8i4a6h	201	13	]	]	-RRB-
cord-006788-kz8i4a6h	201	14	[	[	-LRB-
cord-006788-kz8i4a6h	201	15	167	167	CD
cord-006788-kz8i4a6h	201	16	]	]	-RRB-
cord-006788-kz8i4a6h	201	17	[	[	-LRB-
cord-006788-kz8i4a6h	201	18	168	168	CD
cord-006788-kz8i4a6h	201	19	]	]	-RRB-
cord-006788-kz8i4a6h	201	20	.	.	.
cord-006788-kz8i4a6h	202	1	Osteoblastic	osteoblastic	JJ
cord-006788-kz8i4a6h	202	2	cells	cell	NNS
cord-006788-kz8i4a6h	202	3	in	in	IN
cord-006788-kz8i4a6h	202	4	osseous	osseous	JJ
cord-006788-kz8i4a6h	202	5	tissue	tissue	NN
cord-006788-kz8i4a6h	202	6	are	be	VBP
cord-006788-kz8i4a6h	202	7	the	the	DT
cord-006788-kz8i4a6h	202	8	major	major	JJ
cord-006788-kz8i4a6h	202	9	source	source	NN
cord-006788-kz8i4a6h	202	10	of	of	IN
cord-006788-kz8i4a6h	202	11	FGF23	fgf23	NN
cord-006788-kz8i4a6h	202	12	in	in	IN
cord-006788-kz8i4a6h	202	13	response	response	NN
cord-006788-kz8i4a6h	202	14	to	to	IN
cord-006788-kz8i4a6h	202	15	elevated	elevated	JJ
cord-006788-kz8i4a6h	202	16	calcitriol	calcitriol	NN
cord-006788-kz8i4a6h	202	17	,	,	,
cord-006788-kz8i4a6h	202	18	increased	increase	VBN
cord-006788-kz8i4a6h	202	19	phosphate	phosphate	NN
cord-006788-kz8i4a6h	202	20	and	and	CC
cord-006788-kz8i4a6h	202	21	calcium	calcium	NN
cord-006788-kz8i4a6h	202	22	burdens	burden	NNS
cord-006788-kz8i4a6h	202	23	,	,	,
cord-006788-kz8i4a6h	202	24	increased	increase	VBN
cord-006788-kz8i4a6h	202	25	parathyroid	parathyroid	JJ
cord-006788-kz8i4a6h	202	26	hormone	hormone	NN
cord-006788-kz8i4a6h	202	27	,	,	,
cord-006788-kz8i4a6h	202	28	iron	iron	NN
cord-006788-kz8i4a6h	202	29	and	and	CC
cord-006788-kz8i4a6h	202	30	magnesium	magnesium	NN
cord-006788-kz8i4a6h	202	31	loss	loss	NN
cord-006788-kz8i4a6h	202	32	,	,	,
cord-006788-kz8i4a6h	202	33	and	and	CC
cord-006788-kz8i4a6h	202	34	active	active	JJ
cord-006788-kz8i4a6h	202	35	bone	bone	NN
cord-006788-kz8i4a6h	202	36	remodeling	remodeling	NN
cord-006788-kz8i4a6h	202	37	in	in	IN
cord-006788-kz8i4a6h	202	38	a	a	DT
cord-006788-kz8i4a6h	202	39	vitamin	vitamin	NN
cord-006788-kz8i4a6h	202	40	D	d	NN
cord-006788-kz8i4a6h	202	41	receptor	receptor	NN
cord-006788-kz8i4a6h	202	42	dependent	dependent	JJ
cord-006788-kz8i4a6h	202	43	mechanism	mechanism	NN
cord-006788-kz8i4a6h	202	44	.	.	.
cord-006788-kz8i4a6h	203	1	Acting	act	VBG
cord-006788-kz8i4a6h	203	2	on	on	IN
cord-006788-kz8i4a6h	203	3	kidneys	kidney	NNS
cord-006788-kz8i4a6h	203	4	that	that	WDT
cord-006788-kz8i4a6h	203	5	express	express	VBP
cord-006788-kz8i4a6h	203	6	the	the	DT
cord-006788-kz8i4a6h	203	7	FGFR1-KL	FGFR1-KL	NNP
cord-006788-kz8i4a6h	203	8	complex	complex	NN
cord-006788-kz8i4a6h	203	9	,	,	,
cord-006788-kz8i4a6h	203	10	the	the	DT
cord-006788-kz8i4a6h	203	11	FGF23	fgf23	NN
cord-006788-kz8i4a6h	203	12	signal	signal	NN
cord-006788-kz8i4a6h	203	13	axis	axis	NN
cord-006788-kz8i4a6h	203	14	represses	repress	VBZ
cord-006788-kz8i4a6h	203	15	the	the	DT
cord-006788-kz8i4a6h	203	16	expression	expression	NN
cord-006788-kz8i4a6h	203	17	of	of	IN
cord-006788-kz8i4a6h	203	18	NPT2a	NPT2a	NNP
cord-006788-kz8i4a6h	203	19	and	and	CC
cord-006788-kz8i4a6h	203	20	NPT2c	NPT2c	NNP
cord-006788-kz8i4a6h	203	21	,	,	,
cord-006788-kz8i4a6h	203	22	the	the	DT
cord-006788-kz8i4a6h	203	23	sodium	sodium	NN
cord-006788-kz8i4a6h	203	24	-	-	HYPH
cord-006788-kz8i4a6h	203	25	phosphate	phosphate	NN
cord-006788-kz8i4a6h	203	26	cotransporters	cotransporter	NNS
cord-006788-kz8i4a6h	203	27	in	in	IN
cord-006788-kz8i4a6h	203	28	the	the	DT
cord-006788-kz8i4a6h	203	29	proximal	proximal	JJ
cord-006788-kz8i4a6h	203	30	tubule	tubule	NN
cord-006788-kz8i4a6h	203	31	,	,	,
cord-006788-kz8i4a6h	203	32	thereby	thereby	RB
cord-006788-kz8i4a6h	203	33	decreasing	decrease	VBG
cord-006788-kz8i4a6h	203	34	reabsorption	reabsorption	NN
cord-006788-kz8i4a6h	203	35	and	and	CC
cord-006788-kz8i4a6h	203	36	increasing	increase	VBG
cord-006788-kz8i4a6h	203	37	secretion	secretion	NN
cord-006788-kz8i4a6h	203	38	of	of	IN
cord-006788-kz8i4a6h	203	39	phosphate	phosphate	NN
cord-006788-kz8i4a6h	203	40	in	in	IN
cord-006788-kz8i4a6h	203	41	renal	renal	JJ
cord-006788-kz8i4a6h	203	42	brush	brush	NN
cord-006788-kz8i4a6h	203	43	border	border	NN
cord-006788-kz8i4a6h	203	44	membrane	membrane	NN
cord-006788-kz8i4a6h	203	45	vesicles	vesicle	NNS
cord-006788-kz8i4a6h	203	46	.	.	.
cord-006788-kz8i4a6h	204	1	Another	another	DT
cord-006788-kz8i4a6h	204	2	important	important	JJ
cord-006788-kz8i4a6h	204	3	function	function	NN
cord-006788-kz8i4a6h	204	4	of	of	IN
cord-006788-kz8i4a6h	204	5	this	this	DT
cord-006788-kz8i4a6h	204	6	bone	bone	NN
cord-006788-kz8i4a6h	204	7	to	to	IN
cord-006788-kz8i4a6h	204	8	kidney	kidney	NN
cord-006788-kz8i4a6h	204	9	FGF23	fgf23	NN
cord-006788-kz8i4a6h	204	10	signal	signal	NN
cord-006788-kz8i4a6h	204	11	axis	axis	NN
cord-006788-kz8i4a6h	204	12	is	be	VBZ
cord-006788-kz8i4a6h	204	13	suppressing	suppress	VBG
cord-006788-kz8i4a6h	204	14	the	the	DT
cord-006788-kz8i4a6h	204	15	expression	expression	NN
cord-006788-kz8i4a6h	204	16	of	of	IN
cord-006788-kz8i4a6h	204	17	25-hydroxyvitamin	25-hydroxyvitamin	CD
cord-006788-kz8i4a6h	204	18	D3	D3	NNP
cord-006788-kz8i4a6h	204	19	-	-	HYPH
cord-006788-kz8i4a6h	204	20	1-α	1-α	CD
cord-006788-kz8i4a6h	204	21	-	-	HYPH
cord-006788-kz8i4a6h	204	22	hydroxylase	hydroxylase	NN
cord-006788-kz8i4a6h	204	23	and	and	CC
cord-006788-kz8i4a6h	204	24	stimulating	stimulate	VBG
cord-006788-kz8i4a6h	204	25	the	the	DT
cord-006788-kz8i4a6h	204	26	expression	expression	NN
cord-006788-kz8i4a6h	204	27	of	of	IN
cord-006788-kz8i4a6h	204	28	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	CD
cord-006788-kz8i4a6h	204	29	D(3	d(3	CD
cord-006788-kz8i4a6h	204	30	)	)	-RRB-
cord-006788-kz8i4a6h	204	31	24-hydroxylase	24-hydroxylase	CD
cord-006788-kz8i4a6h	204	32	,	,	,
cord-006788-kz8i4a6h	204	33	thereby	thereby	RB
cord-006788-kz8i4a6h	204	34	inhibiting	inhibit	VBG
cord-006788-kz8i4a6h	204	35	the	the	DT
cord-006788-kz8i4a6h	204	36	production	production	NN
cord-006788-kz8i4a6h	204	37	of	of	IN
cord-006788-kz8i4a6h	204	38	active	active	JJ
cord-006788-kz8i4a6h	204	39	calcitriol	calcitriol	NN
cord-006788-kz8i4a6h	204	40	in	in	IN
cord-006788-kz8i4a6h	204	41	renal	renal	JJ
cord-006788-kz8i4a6h	204	42	proximal	proximal	JJ
cord-006788-kz8i4a6h	204	43	tubules	tubule	NNS
cord-006788-kz8i4a6h	204	44	,	,	,
cord-006788-kz8i4a6h	204	45	which	which	WDT
cord-006788-kz8i4a6h	204	46	subsequently	subsequently	RB
cord-006788-kz8i4a6h	204	47	inhibits	inhibit	VBZ
cord-006788-kz8i4a6h	204	48	the	the	DT
cord-006788-kz8i4a6h	204	49	expression	expression	NN
cord-006788-kz8i4a6h	204	50	of	of	IN
cord-006788-kz8i4a6h	204	51	NPT2b	NPT2b	NNP
cord-006788-kz8i4a6h	204	52	and	and	CC
cord-006788-kz8i4a6h	204	53	phosphate	phosphate	NN
cord-006788-kz8i4a6h	204	54	absorption	absorption	NN
cord-006788-kz8i4a6h	204	55	in	in	IN
cord-006788-kz8i4a6h	204	56	the	the	DT
cord-006788-kz8i4a6h	204	57	apical	apical	JJ
cord-006788-kz8i4a6h	204	58	brush	brush	NN
cord-006788-kz8i4a6h	204	59	border	border	NN
cord-006788-kz8i4a6h	204	60	of	of	IN
cord-006788-kz8i4a6h	204	61	small	small	JJ
cord-006788-kz8i4a6h	204	62	intestine	intestine	NN
cord-006788-kz8i4a6h	204	63	.	.	.
cord-006788-kz8i4a6h	205	1	The	the	DT
cord-006788-kz8i4a6h	205	2	bone	bone	NN
cord-006788-kz8i4a6h	205	3	FGF23	fgf23	NN
cord-006788-kz8i4a6h	205	4	acts	act	VBZ
cord-006788-kz8i4a6h	205	5	on	on	IN
cord-006788-kz8i4a6h	205	6	the	the	DT
cord-006788-kz8i4a6h	205	7	basolateral	basolateral	JJ
cord-006788-kz8i4a6h	205	8	FGFR1-KL	fgfr1-kl	CD
cord-006788-kz8i4a6h	205	9	complex	complex	NN
cord-006788-kz8i4a6h	205	10	in	in	IN
cord-006788-kz8i4a6h	205	11	the	the	DT
cord-006788-kz8i4a6h	205	12	renal	renal	JJ
cord-006788-kz8i4a6h	205	13	distal	distal	JJ
cord-006788-kz8i4a6h	205	14	tubules	tubule	NNS
cord-006788-kz8i4a6h	205	15	to	to	TO
cord-006788-kz8i4a6h	205	16	increase	increase	VB
cord-006788-kz8i4a6h	205	17	the	the	DT
cord-006788-kz8i4a6h	205	18	intracellular	intracellular	JJ
cord-006788-kz8i4a6h	205	19	transport	transport	NN
cord-006788-kz8i4a6h	205	20	of	of	IN
cord-006788-kz8i4a6h	205	21	fully	fully	RB
cord-006788-kz8i4a6h	205	22	glycosylated	glycosylate	VBN
cord-006788-kz8i4a6h	205	23	TRPV5	TRPV5	NNS
cord-006788-kz8i4a6h	205	24	from	from	IN
cord-006788-kz8i4a6h	205	25	the	the	DT
cord-006788-kz8i4a6h	205	26	Golgi	Golgi	NNP
cord-006788-kz8i4a6h	205	27	apparatus	apparatus	NN
cord-006788-kz8i4a6h	205	28	to	to	IN
cord-006788-kz8i4a6h	205	29	the	the	DT
cord-006788-kz8i4a6h	205	30	plasma	plasma	NN
cord-006788-kz8i4a6h	205	31	membrane	membrane	NN
cord-006788-kz8i4a6h	205	32	,	,	,
cord-006788-kz8i4a6h	205	33	thereby	thereby	RB
cord-006788-kz8i4a6h	205	34	stimulating	stimulate	VBG
cord-006788-kz8i4a6h	205	35	calcium	calcium	NN
cord-006788-kz8i4a6h	205	36	reabsorption	reabsorption	NN
cord-006788-kz8i4a6h	205	37	in	in	IN
cord-006788-kz8i4a6h	205	38	distal	distal	JJ
cord-006788-kz8i4a6h	205	39	renal	renal	JJ
cord-006788-kz8i4a6h	205	40	tubules	tubule	NNS
cord-006788-kz8i4a6h	205	41	and	and	CC
cord-006788-kz8i4a6h	205	42	preventing	prevent	VBG
cord-006788-kz8i4a6h	205	43	calcium	calcium	NN
cord-006788-kz8i4a6h	205	44	loss	loss	NN
cord-006788-kz8i4a6h	205	45	[	[	-LRB-
cord-006788-kz8i4a6h	205	46	169	169	CD
cord-006788-kz8i4a6h	205	47	]	]	-RRB-
cord-006788-kz8i4a6h	205	48	.	.	.
cord-006788-kz8i4a6h	206	1	These	these	DT
cord-006788-kz8i4a6h	206	2	FGF23-associated	fgf23-associate	VBN
cord-006788-kz8i4a6h	206	3	axes	axis	NNS
cord-006788-kz8i4a6h	206	4	also	also	RB
cord-006788-kz8i4a6h	206	5	directly	directly	RB
cord-006788-kz8i4a6h	206	6	increase	increase	VB
cord-006788-kz8i4a6h	206	7	the	the	DT
cord-006788-kz8i4a6h	206	8	membrane	membrane	NN
cord-006788-kz8i4a6h	206	9	abundance	abundance	NN
cord-006788-kz8i4a6h	206	10	of	of	IN
cord-006788-kz8i4a6h	206	11	the	the	DT
cord-006788-kz8i4a6h	206	12	Na	Na	NNP
cord-006788-kz8i4a6h	206	13	+	+	CC
cord-006788-kz8i4a6h	206	14	:	:	:
cord-006788-kz8i4a6h	207	1	Clcotransporter	Clcotransporter	NNP
cord-006788-kz8i4a6h	207	2	NCC	NCC	NNP
cord-006788-kz8i4a6h	207	3	in	in	IN
cord-006788-kz8i4a6h	207	4	distal	distal	JJ
cord-006788-kz8i4a6h	207	5	renal	renal	JJ
cord-006788-kz8i4a6h	207	6	tubules	tubule	NNS
cord-006788-kz8i4a6h	207	7	,	,	,
cord-006788-kz8i4a6h	207	8	and	and	CC
cord-006788-kz8i4a6h	207	9	thus	thus	RB
cord-006788-kz8i4a6h	207	10	,	,	,
cord-006788-kz8i4a6h	207	11	increase	increase	VB
cord-006788-kz8i4a6h	207	12	sodium	sodium	NN
cord-006788-kz8i4a6h	207	13	reabsorption	reabsorption	NN
cord-006788-kz8i4a6h	207	14	,	,	,
cord-006788-kz8i4a6h	207	15	plasma	plasma	NN
cord-006788-kz8i4a6h	207	16	volume	volume	NN
cord-006788-kz8i4a6h	207	17	,	,	,
cord-006788-kz8i4a6h	207	18	and	and	CC
cord-006788-kz8i4a6h	207	19	blood	blood	NN
cord-006788-kz8i4a6h	207	20	pressure	pressure	NN
cord-006788-kz8i4a6h	207	21	[	[	-LRB-
cord-006788-kz8i4a6h	207	22	170	170	CD
cord-006788-kz8i4a6h	207	23	]	]	-RRB-
cord-006788-kz8i4a6h	207	24	.	.	.
cord-006788-kz8i4a6h	208	1	This	this	DT
cord-006788-kz8i4a6h	208	2	change	change	NN
cord-006788-kz8i4a6h	208	3	may	may	MD
cord-006788-kz8i4a6h	208	4	be	be	VB
cord-006788-kz8i4a6h	208	5	a	a	DT
cord-006788-kz8i4a6h	208	6	new	new	JJ
cord-006788-kz8i4a6h	208	7	cause	cause	NN
cord-006788-kz8i4a6h	208	8	of	of	IN
cord-006788-kz8i4a6h	208	9	high	high	JJ
cord-006788-kz8i4a6h	208	10	blood	blood	NN
cord-006788-kz8i4a6h	208	11	pressure	pressure	NN
cord-006788-kz8i4a6h	208	12	and	and	CC
cord-006788-kz8i4a6h	208	13	heart	heart	NN
cord-006788-kz8i4a6h	208	14	disease	disease	NN
cord-006788-kz8i4a6h	208	15	under	under	IN
cord-006788-kz8i4a6h	208	16	the	the	DT
cord-006788-kz8i4a6h	208	17	modern	modern	JJ
cord-006788-kz8i4a6h	208	18	processed	process	VBN
cord-006788-kz8i4a6h	208	19	phosphaterich	phosphaterich	NN
cord-006788-kz8i4a6h	208	20	foods	food	NNS
cord-006788-kz8i4a6h	208	21	.	.	.
cord-006788-kz8i4a6h	209	1	Bone	Bone	NNP
cord-006788-kz8i4a6h	209	2	FGF23	FGF23	NNP
cord-006788-kz8i4a6h	209	3	also	also	RB
cord-006788-kz8i4a6h	209	4	acts	act	VBZ
cord-006788-kz8i4a6h	209	5	on	on	IN
cord-006788-kz8i4a6h	209	6	the	the	DT
cord-006788-kz8i4a6h	209	7	parathyroid	parathyroid	JJ
cord-006788-kz8i4a6h	209	8	gland	gland	NN
cord-006788-kz8i4a6h	209	9	to	to	TO
cord-006788-kz8i4a6h	209	10	inhibit	inhibit	VB
cord-006788-kz8i4a6h	209	11	the	the	DT
cord-006788-kz8i4a6h	209	12	production	production	NN
cord-006788-kz8i4a6h	209	13	and	and	CC
cord-006788-kz8i4a6h	209	14	secretion	secretion	NN
cord-006788-kz8i4a6h	209	15	of	of	IN
cord-006788-kz8i4a6h	209	16	parathyroid	parathyroid	JJ
cord-006788-kz8i4a6h	209	17	hormone	hormone	NN
cord-006788-kz8i4a6h	210	1	(	(	-LRB-
cord-006788-kz8i4a6h	210	2	Fig	Fig	NNP
cord-006788-kz8i4a6h	210	3	.	.	NNP
cord-006788-kz8i4a6h	210	4	4	4	LS
cord-006788-kz8i4a6h	210	5	)	)	-RRB-
cord-006788-kz8i4a6h	210	6	[	[	-LRB-
cord-006788-kz8i4a6h	210	7	171	171	CD
cord-006788-kz8i4a6h	210	8	]	]	-RRB-
cord-006788-kz8i4a6h	210	9	,	,	,
cord-006788-kz8i4a6h	210	10	which	which	WDT
cord-006788-kz8i4a6h	210	11	then	then	RB
cord-006788-kz8i4a6h	210	12	reduces	reduce	VBZ
cord-006788-kz8i4a6h	210	13	serum	serum	NN
cord-006788-kz8i4a6h	210	14	calcium	calcium	NN
cord-006788-kz8i4a6h	210	15	through	through	IN
cord-006788-kz8i4a6h	210	16	its	-PRON-	PRP$
cord-006788-kz8i4a6h	210	17	effects	effect	NNS
cord-006788-kz8i4a6h	210	18	on	on	IN
cord-006788-kz8i4a6h	210	19	the	the	DT
cord-006788-kz8i4a6h	210	20	bone	bone	NN
cord-006788-kz8i4a6h	210	21	,	,	,
cord-006788-kz8i4a6h	210	22	kidney	kidney	NN
cord-006788-kz8i4a6h	210	23	,	,	,
cord-006788-kz8i4a6h	210	24	and	and	CC
cord-006788-kz8i4a6h	210	25	intestine	intestine	NN
cord-006788-kz8i4a6h	210	26	.	.	.
cord-006788-kz8i4a6h	211	1	High	high	JJ
cord-006788-kz8i4a6h	211	2	serum	serum	NN
cord-006788-kz8i4a6h	211	3	FGF23	fgf23	NN
cord-006788-kz8i4a6h	211	4	levels	level	NNS
cord-006788-kz8i4a6h	211	5	in	in	IN
cord-006788-kz8i4a6h	211	6	patients	patient	NNS
cord-006788-kz8i4a6h	211	7	with	with	IN
cord-006788-kz8i4a6h	211	8	CKD	CKD	NNP
cord-006788-kz8i4a6h	211	9	decrease	decrease	NN
cord-006788-kz8i4a6h	211	10	calcitriol	calcitriol	NN
cord-006788-kz8i4a6h	211	11	,	,	,
cord-006788-kz8i4a6h	211	12	thereby	thereby	RB
cord-006788-kz8i4a6h	211	13	contributing	contribute	VBG
cord-006788-kz8i4a6h	211	14	to	to	IN
cord-006788-kz8i4a6h	211	15	the	the	DT
cord-006788-kz8i4a6h	211	16	development	development	NN
cord-006788-kz8i4a6h	211	17	of	of	IN
cord-006788-kz8i4a6h	211	18	secondary	secondary	JJ
cord-006788-kz8i4a6h	211	19	hyperparathyroidism	hyperparathyroidism	NN
cord-006788-kz8i4a6h	211	20	,	,	,
cord-006788-kz8i4a6h	211	21	which	which	WDT
cord-006788-kz8i4a6h	211	22	has	have	VBZ
cord-006788-kz8i4a6h	211	23	a	a	DT
cord-006788-kz8i4a6h	211	24	crucial	crucial	JJ
cord-006788-kz8i4a6h	211	25	role	role	NN
cord-006788-kz8i4a6h	211	26	in	in	IN
cord-006788-kz8i4a6h	211	27	increasing	increase	VBG
cord-006788-kz8i4a6h	211	28	the	the	DT
cord-006788-kz8i4a6h	211	29	levels	level	NNS
cord-006788-kz8i4a6h	211	30	of	of	IN
cord-006788-kz8i4a6h	211	31	FGF23	fgf23	NN
cord-006788-kz8i4a6h	211	32	because	because	IN
cord-006788-kz8i4a6h	211	33	the	the	DT
cord-006788-kz8i4a6h	211	34	parathyroid	parathyroid	JJ
cord-006788-kz8i4a6h	211	35	hormone	hormone	NN
cord-006788-kz8i4a6h	211	36	stimulates	stimulate	VBZ
cord-006788-kz8i4a6h	211	37	FGF23	fgf23	CD
cord-006788-kz8i4a6h	211	38	expression	expression	NN
cord-006788-kz8i4a6h	211	39	.	.	.
cord-006788-kz8i4a6h	212	1	Recent	recent	JJ
cord-006788-kz8i4a6h	212	2	studies	study	NNS
cord-006788-kz8i4a6h	212	3	revealed	reveal	VBD
cord-006788-kz8i4a6h	212	4	the	the	DT
cord-006788-kz8i4a6h	212	5	potential	potential	JJ
cord-006788-kz8i4a6h	212	6	roles	role	NNS
cord-006788-kz8i4a6h	212	7	of	of	IN
cord-006788-kz8i4a6h	212	8	the	the	DT
cord-006788-kz8i4a6h	212	9	FGF23	fgf23	NN
cord-006788-kz8i4a6h	212	10	axis	axis	NN
cord-006788-kz8i4a6h	212	11	in	in	IN
cord-006788-kz8i4a6h	212	12	suppressing	suppress	VBG
cord-006788-kz8i4a6h	212	13	erythropoiesis	erythropoiesis	NN
cord-006788-kz8i4a6h	212	14	in	in	IN
cord-006788-kz8i4a6h	212	15	bone	bone	NN
cord-006788-kz8i4a6h	212	16	marrow	marrow	NN
cord-006788-kz8i4a6h	212	17	.	.	.
cord-006788-kz8i4a6h	213	1	Erythroid	Erythroid	NNP
cord-006788-kz8i4a6h	213	2	progenitor	progenitor	NN
cord-006788-kz8i4a6h	213	3	cells	cell	NNS
cord-006788-kz8i4a6h	213	4	highly	highly	RB
cord-006788-kz8i4a6h	213	5	express	express	VBP
cord-006788-kz8i4a6h	213	6	FGF23	FGF23	NNP
cord-006788-kz8i4a6h	213	7	and	and	CC
cord-006788-kz8i4a6h	213	8	FGFR	FGFR	NNP
cord-006788-kz8i4a6h	213	9	-	-	HYPH
cord-006788-kz8i4a6h	213	10	KL	KL	NNP
cord-006788-kz8i4a6h	213	11	,	,	,
cord-006788-kz8i4a6h	213	12	suggesting	suggest	VBG
cord-006788-kz8i4a6h	213	13	that	that	IN
cord-006788-kz8i4a6h	213	14	they	-PRON-	PRP
cord-006788-kz8i4a6h	213	15	are	be	VBP
cord-006788-kz8i4a6h	213	16	both	both	DT
cord-006788-kz8i4a6h	213	17	a	a	DT
cord-006788-kz8i4a6h	213	18	source	source	NN
cord-006788-kz8i4a6h	213	19	and	and	CC
cord-006788-kz8i4a6h	213	20	a	a	DT
cord-006788-kz8i4a6h	213	21	target	target	NN
cord-006788-kz8i4a6h	213	22	of	of	IN
cord-006788-kz8i4a6h	213	23	FGF23	fgf23	NN
cord-006788-kz8i4a6h	213	24	.	.	.
cord-006788-kz8i4a6h	214	1	The	the	DT
cord-006788-kz8i4a6h	214	2	loss	loss	NN
cord-006788-kz8i4a6h	214	3	of	of	IN
cord-006788-kz8i4a6h	214	4	FGF23	fgf23	NN
cord-006788-kz8i4a6h	214	5	or	or	CC
cord-006788-kz8i4a6h	214	6	injection	injection	NN
cord-006788-kz8i4a6h	214	7	of	of	IN
cord-006788-kz8i4a6h	214	8	an	an	DT
cord-006788-kz8i4a6h	214	9	FGF23-blocking	fgf23-blocke	VBG
cord-006788-kz8i4a6h	214	10	peptide	peptide	NN
cord-006788-kz8i4a6h	214	11	in	in	IN
cord-006788-kz8i4a6h	214	12	mice	mice	NN
cord-006788-kz8i4a6h	214	13	results	result	NNS
cord-006788-kz8i4a6h	214	14	in	in	IN
cord-006788-kz8i4a6h	214	15	increased	increase	VBN
cord-006788-kz8i4a6h	214	16	erythropoiesis	erythropoiesis	NN
cord-006788-kz8i4a6h	214	17	,	,	,
cord-006788-kz8i4a6h	214	18	reduced	reduce	VBN
cord-006788-kz8i4a6h	214	19	erythroid	erythroid	NN
cord-006788-kz8i4a6h	214	20	cell	cell	NN
cord-006788-kz8i4a6h	214	21	apoptosis	apoptosis	NN
cord-006788-kz8i4a6h	214	22	,	,	,
cord-006788-kz8i4a6h	214	23	and	and	CC
cord-006788-kz8i4a6h	214	24	increased	increase	VBN
cord-006788-kz8i4a6h	214	25	renal	renal	JJ
cord-006788-kz8i4a6h	214	26	and	and	CC
cord-006788-kz8i4a6h	214	27	bone	bone	NN
cord-006788-kz8i4a6h	214	28	marrow	marrow	NN
cord-006788-kz8i4a6h	214	29	erythropoietin	erythropoietin	NN
cord-006788-kz8i4a6h	214	30	(	(	-LRB-
cord-006788-kz8i4a6h	214	31	EPO	EPO	NNP
cord-006788-kz8i4a6h	214	32	)	)	-RRB-
cord-006788-kz8i4a6h	214	33	expression	expression	NN
cord-006788-kz8i4a6h	214	34	with	with	IN
cord-006788-kz8i4a6h	214	35	increased	increase	VBN
cord-006788-kz8i4a6h	214	36	circulating	circulate	VBG
cord-006788-kz8i4a6h	214	37	EPO	EPO	NNP
cord-006788-kz8i4a6h	214	38	levels	level	NNS
cord-006788-kz8i4a6h	214	39	.	.	.
cord-006788-kz8i4a6h	215	1	On	on	IN
cord-006788-kz8i4a6h	215	2	the	the	DT
cord-006788-kz8i4a6h	215	3	other	other	JJ
cord-006788-kz8i4a6h	215	4	hand	hand	NN
cord-006788-kz8i4a6h	215	5	,	,	,
cord-006788-kz8i4a6h	215	6	the	the	DT
cord-006788-kz8i4a6h	215	7	increased	increase	VBN
cord-006788-kz8i4a6h	215	8	EPO	EPO	NNP
cord-006788-kz8i4a6h	215	9	or	or	CC
cord-006788-kz8i4a6h	215	10	acute	acute	JJ
cord-006788-kz8i4a6h	215	11	blood	blood	NN
cord-006788-kz8i4a6h	215	12	loss	loss	NN
cord-006788-kz8i4a6h	215	13	increases	increase	VBZ
cord-006788-kz8i4a6h	215	14	FGF23	fgf23	CD
cord-006788-kz8i4a6h	215	15	expression	expression	NN
cord-006788-kz8i4a6h	215	16	in	in	IN
cord-006788-kz8i4a6h	215	17	the	the	DT
cord-006788-kz8i4a6h	215	18	bone	bone	NN
cord-006788-kz8i4a6h	215	19	marrow	marrow	NN
cord-006788-kz8i4a6h	215	20	with	with	IN
cord-006788-kz8i4a6h	215	21	a	a	DT
cord-006788-kz8i4a6h	215	22	concomitant	concomitant	JJ
cord-006788-kz8i4a6h	215	23	increase	increase	NN
cord-006788-kz8i4a6h	215	24	in	in	IN
cord-006788-kz8i4a6h	215	25	serum	serum	NN
cord-006788-kz8i4a6h	215	26	FGF23	fgf23	NN
cord-006788-kz8i4a6h	215	27	[	[	-LRB-
cord-006788-kz8i4a6h	215	28	172	172	CD
cord-006788-kz8i4a6h	215	29	,	,	,
cord-006788-kz8i4a6h	215	30	173	173	CD
cord-006788-kz8i4a6h	215	31	]	]	-RRB-
cord-006788-kz8i4a6h	215	32	.	.	.
cord-006788-kz8i4a6h	216	1	A	a	DT
cord-006788-kz8i4a6h	216	2	recent	recent	JJ
cord-006788-kz8i4a6h	216	3	study	study	NN
cord-006788-kz8i4a6h	216	4	suggests	suggest	VBZ
cord-006788-kz8i4a6h	216	5	that	that	IN
cord-006788-kz8i4a6h	216	6	FGF23	fgf23	NN
cord-006788-kz8i4a6h	216	7	is	be	VBZ
cord-006788-kz8i4a6h	216	8	involved	involve	VBN
cord-006788-kz8i4a6h	216	9	in	in	IN
cord-006788-kz8i4a6h	216	10	the	the	DT
cord-006788-kz8i4a6h	216	11	association	association	NN
cord-006788-kz8i4a6h	216	12	between	between	IN
cord-006788-kz8i4a6h	216	13	functional	functional	JJ
cord-006788-kz8i4a6h	216	14	iron	iron	NN
cord-006788-kz8i4a6h	216	15	deficiency	deficiency	NN
cord-006788-kz8i4a6h	216	16	,	,	,
cord-006788-kz8i4a6h	216	17	increased	increase	VBN
cord-006788-kz8i4a6h	216	18	EPO	EPO	NNP
cord-006788-kz8i4a6h	216	19	levels	level	NNS
cord-006788-kz8i4a6h	216	20	,	,	,
cord-006788-kz8i4a6h	216	21	and	and	CC
cord-006788-kz8i4a6h	216	22	death	death	NN
cord-006788-kz8i4a6h	216	23	.	.	.
cord-006788-kz8i4a6h	217	1	The	the	DT
cord-006788-kz8i4a6h	217	2	further	further	JJ
cord-006788-kz8i4a6h	217	3	elucidation	elucidation	NN
cord-006788-kz8i4a6h	217	4	of	of	IN
cord-006788-kz8i4a6h	217	5	the	the	DT
cord-006788-kz8i4a6h	217	6	role	role	NN
cord-006788-kz8i4a6h	217	7	of	of	IN
cord-006788-kz8i4a6h	217	8	the	the	DT
cord-006788-kz8i4a6h	217	9	EPO	EPO	NNP
cord-006788-kz8i4a6h	217	10	-	-	HYPH
cord-006788-kz8i4a6h	217	11	FGF23	FGF23	NNP
cord-006788-kz8i4a6h	217	12	signaling	signal	VBG
cord-006788-kz8i4a6h	217	13	axis	axis	NN
cord-006788-kz8i4a6h	217	14	in	in	IN
cord-006788-kz8i4a6h	217	15	hereditary	hereditary	JJ
cord-006788-kz8i4a6h	217	16	anemia	anemia	NN
cord-006788-kz8i4a6h	217	17	and	and	CC
cord-006788-kz8i4a6h	217	18	chronic	chronic	JJ
cord-006788-kz8i4a6h	217	19	hemolytic	hemolytic	JJ
cord-006788-kz8i4a6h	217	20	diseases	disease	NNS
cord-006788-kz8i4a6h	217	21	,	,	,
cord-006788-kz8i4a6h	217	22	CKD	CKD	NNP
cord-006788-kz8i4a6h	217	23	,	,	,
cord-006788-kz8i4a6h	217	24	and	and	CC
cord-006788-kz8i4a6h	217	25	mineralization	mineralization	NN
cord-006788-kz8i4a6h	217	26	disorders	disorder	NNS
cord-006788-kz8i4a6h	217	27	will	will	MD
cord-006788-kz8i4a6h	217	28	add	add	VB
cord-006788-kz8i4a6h	217	29	to	to	IN
cord-006788-kz8i4a6h	217	30	the	the	DT
cord-006788-kz8i4a6h	217	31	understanding	understanding	NN
cord-006788-kz8i4a6h	217	32	of	of	IN
cord-006788-kz8i4a6h	217	33	the	the	DT
cord-006788-kz8i4a6h	217	34	pathophysiology	pathophysiology	NN
cord-006788-kz8i4a6h	217	35	of	of	IN
cord-006788-kz8i4a6h	217	36	these	these	DT
cord-006788-kz8i4a6h	217	37	diseases	disease	NNS
cord-006788-kz8i4a6h	217	38	and	and	CC
cord-006788-kz8i4a6h	217	39	life	life	NN
cord-006788-kz8i4a6h	217	40	expectancy	expectancy	NN
cord-006788-kz8i4a6h	217	41	and	and	CC
cord-006788-kz8i4a6h	217	42	will	will	MD
cord-006788-kz8i4a6h	217	43	inform	inform	VB
cord-006788-kz8i4a6h	217	44	new	new	JJ
cord-006788-kz8i4a6h	217	45	treatment	treatment	NN
cord-006788-kz8i4a6h	217	46	strategies	strategy	NNS
cord-006788-kz8i4a6h	217	47	for	for	IN
cord-006788-kz8i4a6h	217	48	the	the	DT
cord-006788-kz8i4a6h	217	49	diseases	disease	NNS
cord-006788-kz8i4a6h	217	50	.	.	.
cord-006788-kz8i4a6h	218	1	Current	current	JJ
cord-006788-kz8i4a6h	218	2	evidence	evidence	NN
cord-006788-kz8i4a6h	218	3	indicates	indicate	VBZ
cord-006788-kz8i4a6h	218	4	that	that	IN
cord-006788-kz8i4a6h	218	5	FGF23	fgf23	NN
cord-006788-kz8i4a6h	218	6	is	be	VBZ
cord-006788-kz8i4a6h	218	7	more	more	RBR
cord-006788-kz8i4a6h	218	8	structurally	structurally	RB
cord-006788-kz8i4a6h	218	9	unique	unique	JJ
cord-006788-kz8i4a6h	218	10	than	than	IN
cord-006788-kz8i4a6h	218	11	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	218	12	and	and	CC
cord-006788-kz8i4a6h	218	13	21	21	CD
cord-006788-kz8i4a6h	218	14	[	[	-LRB-
cord-006788-kz8i4a6h	218	15	5	5	CD
cord-006788-kz8i4a6h	218	16	]	]	-RRB-
cord-006788-kz8i4a6h	218	17	.	.	.
cord-006788-kz8i4a6h	219	1	FGF23	fgf23	NN
cord-006788-kz8i4a6h	219	2	contains	contain	VBZ
cord-006788-kz8i4a6h	219	3	a	a	DT
cord-006788-kz8i4a6h	219	4	conserved	conserve	VBN
cord-006788-kz8i4a6h	219	5	furin	furin	NN
cord-006788-kz8i4a6h	219	6	-	-	HYPH
cord-006788-kz8i4a6h	219	7	sensitive	sensitive	JJ
cord-006788-kz8i4a6h	219	8	176	176	CD
cord-006788-kz8i4a6h	219	9	RHTR	RHTR	NNP
cord-006788-kz8i4a6h	219	10	179	179	CD
cord-006788-kz8i4a6h	219	11	cleavage	cleavage	NN
cord-006788-kz8i4a6h	219	12	site	site	NN
cord-006788-kz8i4a6h	219	13	near	near	IN
cord-006788-kz8i4a6h	219	14	the	the	DT
cord-006788-kz8i4a6h	219	15	C	C	NNP
cord-006788-kz8i4a6h	219	16	-	-	HYPH
cord-006788-kz8i4a6h	219	17	terminus	terminus	NN
cord-006788-kz8i4a6h	219	18	,	,	,
cord-006788-kz8i4a6h	219	19	which	which	WDT
cord-006788-kz8i4a6h	219	20	inactivates	inactivate	VBZ
cord-006788-kz8i4a6h	219	21	the	the	DT
cord-006788-kz8i4a6h	219	22	intact	intact	JJ
cord-006788-kz8i4a6h	219	23	FGF23	fgf23	NN
cord-006788-kz8i4a6h	219	24	upon	upon	IN
cord-006788-kz8i4a6h	219	25	cleavage	cleavage	NN
cord-006788-kz8i4a6h	219	26	,	,	,
cord-006788-kz8i4a6h	219	27	leading	lead	VBG
cord-006788-kz8i4a6h	219	28	to	to	IN
cord-006788-kz8i4a6h	219	29	signal	signal	NN
cord-006788-kz8i4a6h	219	30	attenuation	attenuation	NN
cord-006788-kz8i4a6h	219	31	.	.	.
cord-006788-kz8i4a6h	220	1	The	the	DT
cord-006788-kz8i4a6h	220	2	biological	biological	JJ
cord-006788-kz8i4a6h	220	3	importance	importance	NN
cord-006788-kz8i4a6h	220	4	of	of	IN
cord-006788-kz8i4a6h	220	5	this	this	DT
cord-006788-kz8i4a6h	220	6	activity	activity	NN
cord-006788-kz8i4a6h	220	7	control	control	NN
cord-006788-kz8i4a6h	220	8	mechanism	mechanism	NN
cord-006788-kz8i4a6h	220	9	is	be	VBZ
cord-006788-kz8i4a6h	220	10	demonstrated	demonstrate	VBN
cord-006788-kz8i4a6h	220	11	by	by	IN
cord-006788-kz8i4a6h	220	12	point	point	NN
cord-006788-kz8i4a6h	220	13	mutations	mutation	NNS
cord-006788-kz8i4a6h	220	14	(	(	-LRB-
cord-006788-kz8i4a6h	220	15	e.g.	e.g.	RB
cord-006788-kz8i4a6h	220	16	,	,	,
cord-006788-kz8i4a6h	220	17	R176Q	R176Q	NNP
cord-006788-kz8i4a6h	220	18	,	,	,
cord-006788-kz8i4a6h	220	19	R179Q	R179Q	NNP
cord-006788-kz8i4a6h	220	20	,	,	,
cord-006788-kz8i4a6h	220	21	and	and	CC
cord-006788-kz8i4a6h	220	22	R179W	R179W	NNP
cord-006788-kz8i4a6h	220	23	)	)	-RRB-
cord-006788-kz8i4a6h	220	24	of	of	IN
cord-006788-kz8i4a6h	220	25	this	this	DT
cord-006788-kz8i4a6h	220	26	site	site	NN
cord-006788-kz8i4a6h	220	27	,	,	,
cord-006788-kz8i4a6h	220	28	which	which	WDT
cord-006788-kz8i4a6h	220	29	results	result	VBZ
cord-006788-kz8i4a6h	220	30	in	in	IN
cord-006788-kz8i4a6h	220	31	cleavage	cleavage	NN
cord-006788-kz8i4a6h	220	32	-	-	HYPH
cord-006788-kz8i4a6h	220	33	resistant	resistant	JJ
cord-006788-kz8i4a6h	220	34	FGF23	fgf23	NN
cord-006788-kz8i4a6h	220	35	and	and	CC
cord-006788-kz8i4a6h	220	36	increased	increase	VBN
cord-006788-kz8i4a6h	220	37	circulating	circulate	VBG
cord-006788-kz8i4a6h	220	38	levels	level	NNS
cord-006788-kz8i4a6h	220	39	of	of	IN
cord-006788-kz8i4a6h	220	40	active	active	JJ
cord-006788-kz8i4a6h	220	41	FGF23	FGF23	NNP
cord-006788-kz8i4a6h	220	42	,	,	,
cord-006788-kz8i4a6h	220	43	in	in	IN
cord-006788-kz8i4a6h	220	44	autosomal	autosomal	JJ
cord-006788-kz8i4a6h	220	45	dominant	dominant	JJ
cord-006788-kz8i4a6h	220	46	hypophosphatemic	hypophosphatemic	NN
cord-006788-kz8i4a6h	220	47	and	and	CC
cord-006788-kz8i4a6h	220	48	vitamin	vitamin	NN
cord-006788-kz8i4a6h	220	49	Ddeficient	Ddeficient	NNP
cord-006788-kz8i4a6h	220	50	rickets	ricket	NNS
cord-006788-kz8i4a6h	220	51	characterized	characterize	VBN
cord-006788-kz8i4a6h	220	52	by	by	IN
cord-006788-kz8i4a6h	220	53	renal	renal	JJ
cord-006788-kz8i4a6h	220	54	phosphate	phosphate	NN
cord-006788-kz8i4a6h	220	55	wasting	wasting	NN
cord-006788-kz8i4a6h	220	56	,	,	,
cord-006788-kz8i4a6h	220	57	hypophosphatemia	hypophosphatemia	NN
cord-006788-kz8i4a6h	220	58	,	,	,
cord-006788-kz8i4a6h	220	59	rickets	ricket	NNS
cord-006788-kz8i4a6h	220	60	,	,	,
cord-006788-kz8i4a6h	220	61	osteomalacia	osteomalacia	NNS
cord-006788-kz8i4a6h	220	62	,	,	,
cord-006788-kz8i4a6h	220	63	leg	leg	NN
cord-006788-kz8i4a6h	220	64	deformities	deformity	NNS
cord-006788-kz8i4a6h	220	65	,	,	,
cord-006788-kz8i4a6h	220	66	short	short	JJ
cord-006788-kz8i4a6h	220	67	stature	stature	NN
cord-006788-kz8i4a6h	220	68	,	,	,
cord-006788-kz8i4a6h	220	69	bone	bone	NN
cord-006788-kz8i4a6h	220	70	pain	pain	NN
cord-006788-kz8i4a6h	220	71	,	,	,
cord-006788-kz8i4a6h	220	72	and	and	CC
cord-006788-kz8i4a6h	220	73	dental	dental	JJ
cord-006788-kz8i4a6h	220	74	abscesses	abscess	NNS
cord-006788-kz8i4a6h	220	75	[	[	-LRB-
cord-006788-kz8i4a6h	220	76	168	168	CD
cord-006788-kz8i4a6h	220	77	,	,	,
cord-006788-kz8i4a6h	220	78	174	174	CD
cord-006788-kz8i4a6h	220	79	,	,	,
cord-006788-kz8i4a6h	220	80	175	175	CD
cord-006788-kz8i4a6h	220	81	]	]	-RRB-
cord-006788-kz8i4a6h	220	82	.	.	.
cord-006788-kz8i4a6h	221	1	FGF23	fgf23	NN
cord-006788-kz8i4a6h	221	2	levels	level	NNS
cord-006788-kz8i4a6h	221	3	are	be	VBP
cord-006788-kz8i4a6h	221	4	increased	increase	VBN
cord-006788-kz8i4a6h	221	5	and	and	CC
cord-006788-kz8i4a6h	221	6	may	may	MD
cord-006788-kz8i4a6h	221	7	play	play	VB
cord-006788-kz8i4a6h	221	8	important	important	JJ
cord-006788-kz8i4a6h	221	9	roles	role	NNS
cord-006788-kz8i4a6h	221	10	in	in	IN
cord-006788-kz8i4a6h	221	11	other	other	JJ
cord-006788-kz8i4a6h	221	12	hereditable	hereditable	JJ
cord-006788-kz8i4a6h	221	13	and	and	CC
cord-006788-kz8i4a6h	221	14	acquired	acquire	VBD
cord-006788-kz8i4a6h	221	15	phosphate	phosphate	NN
cord-006788-kz8i4a6h	221	16	wasting	waste	VBG
cord-006788-kz8i4a6h	221	17	disorders	disorder	NNS
cord-006788-kz8i4a6h	221	18	,	,	,
cord-006788-kz8i4a6h	221	19	including	include	VBG
cord-006788-kz8i4a6h	221	20	X	x	NN
cord-006788-kz8i4a6h	221	21	-	-	HYPH
cord-006788-kz8i4a6h	221	22	linked	link	VBN
cord-006788-kz8i4a6h	221	23	dominant	dominant	JJ
cord-006788-kz8i4a6h	221	24	hypophosphatemic	hypophosphatemic	JJ
cord-006788-kz8i4a6h	221	25	rickets	ricket	NNS
cord-006788-kz8i4a6h	221	26	,	,	,
cord-006788-kz8i4a6h	221	27	autosomal	autosomal	JJ
cord-006788-kz8i4a6h	221	28	recessive	recessive	JJ
cord-006788-kz8i4a6h	221	29	hypophosphatemic	hypophosphatemic	JJ
cord-006788-kz8i4a6h	221	30	rickets	ricket	NNS
cord-006788-kz8i4a6h	221	31	,	,	,
cord-006788-kz8i4a6h	221	32	hypophosphatemic	hypophosphatemic	NNP
cord-006788-kz8i4a6h	221	33	rickets	ricket	NNS
cord-006788-kz8i4a6h	221	34	associated	associate	VBN
cord-006788-kz8i4a6h	221	35	with	with	IN
cord-006788-kz8i4a6h	221	36	McCune	McCune	NNP
cord-006788-kz8i4a6h	221	37	-	-	HYPH
cord-006788-kz8i4a6h	221	38	Albright	Albright	NNP
cord-006788-kz8i4a6h	221	39	syndrome	syndrome	NN
cord-006788-kz8i4a6h	221	40	/	/	SYM
cord-006788-kz8i4a6h	221	41	fibrous	fibrous	JJ
cord-006788-kz8i4a6h	221	42	dysplasia	dysplasia	NN
cord-006788-kz8i4a6h	221	43	of	of	IN
cord-006788-kz8i4a6h	221	44	bone	bone	NN
cord-006788-kz8i4a6h	221	45	,	,	,
cord-006788-kz8i4a6h	221	46	and	and	CC
cord-006788-kz8i4a6h	221	47	linear	linear	JJ
cord-006788-kz8i4a6h	221	48	sebaceous	sebaceous	JJ
cord-006788-kz8i4a6h	221	49	nevus	nevus	NN
cord-006788-kz8i4a6h	221	50	syndrome	syndrome	NN
cord-006788-kz8i4a6h	221	51	[	[	-LRB-
cord-006788-kz8i4a6h	221	52	176	176	CD
cord-006788-kz8i4a6h	221	53	,	,	,
cord-006788-kz8i4a6h	221	54	177	177	CD
cord-006788-kz8i4a6h	221	55	]	]	-RRB-
cord-006788-kz8i4a6h	221	56	.	.	.
cord-006788-kz8i4a6h	222	1	The	the	DT
cord-006788-kz8i4a6h	222	2	increased	increase	VBN
cord-006788-kz8i4a6h	222	3	FGF23	fgf23	NN
cord-006788-kz8i4a6h	222	4	levels	level	NNS
cord-006788-kz8i4a6h	222	5	are	be	VBP
cord-006788-kz8i4a6h	222	6	also	also	RB
cord-006788-kz8i4a6h	222	7	found	find	VBN
cord-006788-kz8i4a6h	222	8	in	in	IN
cord-006788-kz8i4a6h	222	9	acquired	acquire	VBN
cord-006788-kz8i4a6h	222	10	phosphate	phosphate	NN
cord-006788-kz8i4a6h	222	11	wasting	waste	VBG
cord-006788-kz8i4a6h	222	12	disorders	disorder	NNS
cord-006788-kz8i4a6h	222	13	in	in	IN
cord-006788-kz8i4a6h	222	14	some	some	DT
cord-006788-kz8i4a6h	222	15	tumor	tumor	NN
cord-006788-kz8i4a6h	222	16	types	type	NNS
cord-006788-kz8i4a6h	222	17	,	,	,
cord-006788-kz8i4a6h	222	18	such	such	JJ
cord-006788-kz8i4a6h	222	19	as	as	IN
cord-006788-kz8i4a6h	222	20	the	the	DT
cord-006788-kz8i4a6h	222	21	benign	benign	JJ
cord-006788-kz8i4a6h	222	22	mesenchymal	mesenchymal	JJ
cord-006788-kz8i4a6h	222	23	neoplasm	neoplasm	NN
cord-006788-kz8i4a6h	222	24	phosphaturic	phosphaturic	JJ
cord-006788-kz8i4a6h	222	25	mesenchymal	mesenchymal	JJ
cord-006788-kz8i4a6h	222	26	tumor	tumor	NN
cord-006788-kz8i4a6h	222	27	,	,	,
cord-006788-kz8i4a6h	222	28	causing	cause	VBG
cord-006788-kz8i4a6h	222	29	tumor	tumor	NN
cord-006788-kz8i4a6h	222	30	-	-	HYPH
cord-006788-kz8i4a6h	222	31	induced	induce	VBN
cord-006788-kz8i4a6h	222	32	osteomalacia	osteomalacia	NNS
cord-006788-kz8i4a6h	222	33	,	,	,
cord-006788-kz8i4a6h	222	34	a	a	DT
cord-006788-kz8i4a6h	222	35	paraneoplastic	paraneoplastic	JJ
cord-006788-kz8i4a6h	222	36	syndrome	syndrome	NN
cord-006788-kz8i4a6h	222	37	[	[	-LRB-
cord-006788-kz8i4a6h	222	38	168	168	CD
cord-006788-kz8i4a6h	222	39	]	]	-RRB-
cord-006788-kz8i4a6h	222	40	.	.	.
cord-006788-kz8i4a6h	223	1	During	during	IN
cord-006788-kz8i4a6h	223	2	post	post	JJ
cord-006788-kz8i4a6h	223	3	-	-	JJ
cord-006788-kz8i4a6h	223	4	translational	translational	JJ
cord-006788-kz8i4a6h	223	5	modification	modification	NN
cord-006788-kz8i4a6h	223	6	,	,	,
cord-006788-kz8i4a6h	223	7	FGF23	FGF23	NNP
cord-006788-kz8i4a6h	223	8	is	be	VBZ
cord-006788-kz8i4a6h	223	9	glycosylated	glycosylate	VBN
cord-006788-kz8i4a6h	223	10	at	at	IN
cord-006788-kz8i4a6h	223	11	Thr-178	thr-178	CD
cord-006788-kz8i4a6h	223	12	in	in	IN
cord-006788-kz8i4a6h	223	13	the	the	DT
cord-006788-kz8i4a6h	223	14	cleavage	cleavage	NN
cord-006788-kz8i4a6h	223	15	site	site	NN
cord-006788-kz8i4a6h	223	16	by	by	IN
cord-006788-kz8i4a6h	223	17	GalNT3	GalNT3	NNP
cord-006788-kz8i4a6h	223	18	,	,	,
cord-006788-kz8i4a6h	223	19	which	which	WDT
cord-006788-kz8i4a6h	223	20	facilitates	facilitate	VBZ
cord-006788-kz8i4a6h	223	21	its	-PRON-	PRP$
cord-006788-kz8i4a6h	223	22	secretion	secretion	NN
cord-006788-kz8i4a6h	223	23	and	and	CC
cord-006788-kz8i4a6h	223	24	protects	protect	VBZ
cord-006788-kz8i4a6h	223	25	the	the	DT
cord-006788-kz8i4a6h	223	26	protein	protein	NN
cord-006788-kz8i4a6h	223	27	from	from	IN
cord-006788-kz8i4a6h	223	28	being	be	VBG
cord-006788-kz8i4a6h	223	29	broken	break	VBN
cord-006788-kz8i4a6h	223	30	down	down	RP
cord-006788-kz8i4a6h	223	31	,	,	,
cord-006788-kz8i4a6h	223	32	suggesting	suggest	VBG
cord-006788-kz8i4a6h	223	33	a	a	DT
cord-006788-kz8i4a6h	223	34	novel	novel	JJ
cord-006788-kz8i4a6h	223	35	posttranslational	posttranslational	JJ
cord-006788-kz8i4a6h	223	36	regulatory	regulatory	JJ
cord-006788-kz8i4a6h	223	37	model	model	NN
cord-006788-kz8i4a6h	223	38	of	of	IN
cord-006788-kz8i4a6h	223	39	FGF23	FGF23	NNP
cord-006788-kz8i4a6h	223	40	involving	involve	VBG
cord-006788-kz8i4a6h	223	41	competing	compete	VBG
cord-006788-kz8i4a6h	223	42	O	o	NN
cord-006788-kz8i4a6h	223	43	-	-	HYPH
cord-006788-kz8i4a6h	223	44	glycosylation	glycosylation	NN
cord-006788-kz8i4a6h	223	45	and	and	CC
cord-006788-kz8i4a6h	223	46	proteolytic	proteolytic	JJ
cord-006788-kz8i4a6h	223	47	processing	processing	NN
cord-006788-kz8i4a6h	223	48	to	to	TO
cord-006788-kz8i4a6h	223	49	determine	determine	VB
cord-006788-kz8i4a6h	223	50	the	the	DT
cord-006788-kz8i4a6h	223	51	level	level	NN
cord-006788-kz8i4a6h	223	52	of	of	IN
cord-006788-kz8i4a6h	223	53	secreted	secrete	VBN
cord-006788-kz8i4a6h	223	54	active	active	JJ
cord-006788-kz8i4a6h	223	55	FGF23	fgf23	NN
cord-006788-kz8i4a6h	223	56	[	[	-LRB-
cord-006788-kz8i4a6h	223	57	178	178	CD
cord-006788-kz8i4a6h	223	58	]	]	-RRB-
cord-006788-kz8i4a6h	223	59	.	.	.
cord-006788-kz8i4a6h	224	1	The	the	DT
cord-006788-kz8i4a6h	224	2	importance	importance	NN
cord-006788-kz8i4a6h	224	3	of	of	IN
cord-006788-kz8i4a6h	224	4	this	this	DT
cord-006788-kz8i4a6h	224	5	glycosylation	glycosylation	NN
cord-006788-kz8i4a6h	224	6	modification	modification	NN
cord-006788-kz8i4a6h	224	7	is	be	VBZ
cord-006788-kz8i4a6h	224	8	demonstrated	demonstrate	VBN
cord-006788-kz8i4a6h	224	9	by	by	IN
cord-006788-kz8i4a6h	224	10	inactivating	inactivate	VBG
cord-006788-kz8i4a6h	224	11	GalNT3	galnt3	NN
cord-006788-kz8i4a6h	224	12	mutations	mutation	NNS
cord-006788-kz8i4a6h	224	13	that	that	WDT
cord-006788-kz8i4a6h	224	14	render	render	VBP
cord-006788-kz8i4a6h	224	15	FGF23	fgf23	NN
cord-006788-kz8i4a6h	224	16	susceptible	susceptible	JJ
cord-006788-kz8i4a6h	224	17	to	to	IN
cord-006788-kz8i4a6h	224	18	Fig	Fig	NNP
cord-006788-kz8i4a6h	224	19	.	.	.
cord-006788-kz8i4a6h	225	1	4	4	CD
cord-006788-kz8i4a6h	225	2	FGF23	fgf23	NN
cord-006788-kz8i4a6h	225	3	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	225	4	axis	axis	NN
cord-006788-kz8i4a6h	225	5	.	.	.
cord-006788-kz8i4a6h	226	1	The	the	DT
cord-006788-kz8i4a6h	226	2	bone	bone	NN
cord-006788-kz8i4a6h	226	3	-	-	HYPH
cord-006788-kz8i4a6h	226	4	derived	derive	VBN
cord-006788-kz8i4a6h	226	5	FGF23	fgf23	NN
cord-006788-kz8i4a6h	226	6	drives	drive	NNS
cord-006788-kz8i4a6h	226	7	signal	signal	VBP
cord-006788-kz8i4a6h	226	8	axes	axis	NNS
cord-006788-kz8i4a6h	226	9	to	to	TO
cord-006788-kz8i4a6h	226	10	promote	promote	VB
cord-006788-kz8i4a6h	226	11	(	(	-LRB-
cord-006788-kz8i4a6h	226	12	green	green	JJ
cord-006788-kz8i4a6h	226	13	arrows	arrow	NNS
cord-006788-kz8i4a6h	226	14	)	)	-RRB-
cord-006788-kz8i4a6h	226	15	the	the	DT
cord-006788-kz8i4a6h	226	16	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	226	17	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	226	18	of	of	IN
cord-006788-kz8i4a6h	226	19	phosphate	phosphate	NN
cord-006788-kz8i4a6h	226	20	,	,	,
cord-006788-kz8i4a6h	226	21	vitamin	vitamin	NN
cord-006788-kz8i4a6h	226	22	D	d	NN
cord-006788-kz8i4a6h	226	23	,	,	,
cord-006788-kz8i4a6h	226	24	and	and	CC
cord-006788-kz8i4a6h	226	25	calcium	calcium	NN
cord-006788-kz8i4a6h	226	26	through	through	IN
cord-006788-kz8i4a6h	226	27	a	a	DT
cord-006788-kz8i4a6h	226	28	complex	complex	JJ
cord-006788-kz8i4a6h	226	29	interorgan	interorgan	NN
cord-006788-kz8i4a6h	226	30	crosstalk	crosstalk	NN
cord-006788-kz8i4a6h	226	31	network	network	NN
cord-006788-kz8i4a6h	226	32	for	for	IN
cord-006788-kz8i4a6h	226	33	bone	bone	NN
cord-006788-kz8i4a6h	226	34	health	health	NN
cord-006788-kz8i4a6h	226	35	and	and	CC
cord-006788-kz8i4a6h	226	36	systemic	systemic	JJ
cord-006788-kz8i4a6h	226	37	mineral	mineral	NN
cord-006788-kz8i4a6h	226	38	balance	balance	NN
cord-006788-kz8i4a6h	226	39	.	.	.
cord-006788-kz8i4a6h	227	1	The	the	DT
cord-006788-kz8i4a6h	227	2	bone	bone	NN
cord-006788-kz8i4a6h	227	3	to	to	IN
cord-006788-kz8i4a6h	227	4	the	the	DT
cord-006788-kz8i4a6h	227	5	kidney	kidney	NN
cord-006788-kz8i4a6h	227	6	axis	axis	NN
cord-006788-kz8i4a6h	227	7	of	of	IN
cord-006788-kz8i4a6h	227	8	FGF23	FGF23	NNP
cord-006788-kz8i4a6h	227	9	is	be	VBZ
cord-006788-kz8i4a6h	227	10	central	central	JJ
cord-006788-kz8i4a6h	227	11	to	to	IN
cord-006788-kz8i4a6h	227	12	the	the	DT
cord-006788-kz8i4a6h	227	13	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	227	14	roles	role	NNS
cord-006788-kz8i4a6h	227	15	of	of	IN
cord-006788-kz8i4a6h	227	16	FGF23	fgf23	NN
cord-006788-kz8i4a6h	227	17	,	,	,
cord-006788-kz8i4a6h	227	18	which	which	WDT
cord-006788-kz8i4a6h	227	19	inhibits	inhibit	VBZ
cord-006788-kz8i4a6h	227	20	(	(	-LRB-
cord-006788-kz8i4a6h	227	21	red	red	JJ
cord-006788-kz8i4a6h	227	22	long	long	JJ
cord-006788-kz8i4a6h	227	23	-	-	HYPH
cord-006788-kz8i4a6h	227	24	tailed	tailed	JJ
cord-006788-kz8i4a6h	227	25	"	"	``
cord-006788-kz8i4a6h	227	26	T	t	NN
cord-006788-kz8i4a6h	227	27	"	"	''
cord-006788-kz8i4a6h	227	28	sign	sign	NN
cord-006788-kz8i4a6h	227	29	)	)	-RRB-
cord-006788-kz8i4a6h	228	1	the	the	DT
cord-006788-kz8i4a6h	228	2	reabsorption	reabsorption	NN
cord-006788-kz8i4a6h	228	3	of	of	IN
cord-006788-kz8i4a6h	228	4	phosphate	phosphate	NN
cord-006788-kz8i4a6h	228	5	and	and	CC
cord-006788-kz8i4a6h	228	6	the	the	DT
cord-006788-kz8i4a6h	228	7	production	production	NN
cord-006788-kz8i4a6h	228	8	of	of	IN
cord-006788-kz8i4a6h	228	9	active	active	JJ
cord-006788-kz8i4a6h	228	10	calcitriol	calcitriol	NN
cord-006788-kz8i4a6h	228	11	in	in	IN
cord-006788-kz8i4a6h	228	12	renal	renal	JJ
cord-006788-kz8i4a6h	228	13	proximal	proximal	JJ
cord-006788-kz8i4a6h	228	14	tubules	tubule	NNS
cord-006788-kz8i4a6h	228	15	while	while	IN
cord-006788-kz8i4a6h	228	16	increasing	increase	VBG
cord-006788-kz8i4a6h	228	17	the	the	DT
cord-006788-kz8i4a6h	228	18	calcium	calcium	NN
cord-006788-kz8i4a6h	228	19	and	and	CC
cord-006788-kz8i4a6h	228	20	sodium	sodium	NN
cord-006788-kz8i4a6h	228	21	reabsorption	reabsorption	NN
cord-006788-kz8i4a6h	228	22	in	in	IN
cord-006788-kz8i4a6h	228	23	renal	renal	JJ
cord-006788-kz8i4a6h	228	24	distal	distal	JJ
cord-006788-kz8i4a6h	228	25	tubules	tubule	NNS
cord-006788-kz8i4a6h	228	26	.	.	.
cord-006788-kz8i4a6h	229	1	The	the	DT
cord-006788-kz8i4a6h	229	2	bone	bone	NN
cord-006788-kz8i4a6h	229	3	to	to	IN
cord-006788-kz8i4a6h	229	4	parathyroid	parathyroid	JJ
cord-006788-kz8i4a6h	229	5	axis	axis	NN
cord-006788-kz8i4a6h	229	6	of	of	IN
cord-006788-kz8i4a6h	229	7	FGF23	FGF23	NNP
cord-006788-kz8i4a6h	229	8	inhibits	inhibit	VBZ
cord-006788-kz8i4a6h	229	9	the	the	DT
cord-006788-kz8i4a6h	229	10	production	production	NN
cord-006788-kz8i4a6h	229	11	and	and	CC
cord-006788-kz8i4a6h	229	12	secretion	secretion	NN
cord-006788-kz8i4a6h	229	13	of	of	IN
cord-006788-kz8i4a6h	229	14	parathyroid	parathyroid	JJ
cord-006788-kz8i4a6h	229	15	hormone	hormone	NN
cord-006788-kz8i4a6h	229	16	that	that	WDT
cord-006788-kz8i4a6h	229	17	also	also	RB
cord-006788-kz8i4a6h	229	18	plays	play	VBZ
cord-006788-kz8i4a6h	229	19	critical	critical	JJ
cord-006788-kz8i4a6h	229	20	roles	role	NNS
cord-006788-kz8i4a6h	229	21	in	in	IN
cord-006788-kz8i4a6h	229	22	mineral	mineral	NN
cord-006788-kz8i4a6h	229	23	and	and	CC
cord-006788-kz8i4a6h	229	24	vitamin	vitamin	NN
cord-006788-kz8i4a6h	229	25	D	d	NN
cord-006788-kz8i4a6h	229	26	balance	balance	NN
cord-006788-kz8i4a6h	229	27	.	.	.
cord-006788-kz8i4a6h	230	1	proteolysis	proteolysis	NN
cord-006788-kz8i4a6h	230	2	[	[	-LRB-
cord-006788-kz8i4a6h	230	3	179	179	CD
cord-006788-kz8i4a6h	230	4	,	,	,
cord-006788-kz8i4a6h	230	5	180	180	CD
cord-006788-kz8i4a6h	230	6	]	]	-RRB-
cord-006788-kz8i4a6h	230	7	,	,	.
cord-006788-kz8i4a6h	231	1	thereby	thereby	RB
cord-006788-kz8i4a6h	231	2	reducing	reduce	VBG
cord-006788-kz8i4a6h	231	3	circulating	circulate	VBG
cord-006788-kz8i4a6h	231	4	intact	intact	JJ
cord-006788-kz8i4a6h	231	5	hormone	hormone	NN
cord-006788-kz8i4a6h	231	6	levels	level	NNS
cord-006788-kz8i4a6h	231	7	and	and	CC
cord-006788-kz8i4a6h	231	8	leading	lead	VBG
cord-006788-kz8i4a6h	231	9	to	to	IN
cord-006788-kz8i4a6h	231	10	autosomal	autosomal	JJ
cord-006788-kz8i4a6h	231	11	recessive	recessive	JJ
cord-006788-kz8i4a6h	231	12	familial	familial	JJ
cord-006788-kz8i4a6h	231	13	tumoral	tumoral	JJ
cord-006788-kz8i4a6h	231	14	calcinosis	calcinosis	NNP
cord-006788-kz8i4a6h	231	15	that	that	WDT
cord-006788-kz8i4a6h	231	16	manifests	manifest	VBZ
cord-006788-kz8i4a6h	231	17	with	with	IN
cord-006788-kz8i4a6h	231	18	hyperphosphatemic	hyperphosphatemic	JJ
cord-006788-kz8i4a6h	231	19	and	and	CC
cord-006788-kz8i4a6h	231	20	massive	massive	JJ
cord-006788-kz8i4a6h	231	21	calcium	calcium	NN
cord-006788-kz8i4a6h	231	22	deposits	deposit	NNS
cord-006788-kz8i4a6h	231	23	in	in	IN
cord-006788-kz8i4a6h	231	24	the	the	DT
cord-006788-kz8i4a6h	231	25	skin	skin	NN
cord-006788-kz8i4a6h	231	26	and	and	CC
cord-006788-kz8i4a6h	231	27	subcutaneous	subcutaneous	JJ
cord-006788-kz8i4a6h	231	28	tissues	tissue	NNS
cord-006788-kz8i4a6h	231	29	throughout	throughout	IN
cord-006788-kz8i4a6h	231	30	the	the	DT
cord-006788-kz8i4a6h	231	31	body	body	NN
cord-006788-kz8i4a6h	231	32	.	.	.
cord-006788-kz8i4a6h	232	1	Consistently	consistently	RB
cord-006788-kz8i4a6h	232	2	,	,	,
cord-006788-kz8i4a6h	232	3	at	at	RB
cord-006788-kz8i4a6h	232	4	least	least	JJS
cord-006788-kz8i4a6h	232	5	seven	seven	CD
cord-006788-kz8i4a6h	232	6	mutations	mutation	NNS
cord-006788-kz8i4a6h	232	7	in	in	IN
cord-006788-kz8i4a6h	232	8	the	the	DT
cord-006788-kz8i4a6h	232	9	conserved	conserve	VBN
cord-006788-kz8i4a6h	232	10	backbone	backbone	NN
cord-006788-kz8i4a6h	232	11	of	of	IN
cord-006788-kz8i4a6h	232	12	FGF23	fgf23	NN
cord-006788-kz8i4a6h	232	13	,	,	,
cord-006788-kz8i4a6h	232	14	such	such	JJ
cord-006788-kz8i4a6h	232	15	as	as	IN
cord-006788-kz8i4a6h	232	16	S71	S71	NNP
cord-006788-kz8i4a6h	232	17	G	G	NNP
cord-006788-kz8i4a6h	232	18	,	,	,
cord-006788-kz8i4a6h	232	19	M96	M96	NNP
cord-006788-kz8i4a6h	232	20	T	T	NNP
cord-006788-kz8i4a6h	232	21	,	,	,
cord-006788-kz8i4a6h	232	22	S129F	S129F	NNP
cord-006788-kz8i4a6h	232	23	,	,	,
cord-006788-kz8i4a6h	232	24	and	and	CC
cord-006788-kz8i4a6h	232	25	F157L	F157L	NNP
cord-006788-kz8i4a6h	232	26	,	,	,
cord-006788-kz8i4a6h	232	27	destabilize	destabilize	VB
cord-006788-kz8i4a6h	232	28	the	the	DT
cord-006788-kz8i4a6h	232	29	tertiary	tertiary	JJ
cord-006788-kz8i4a6h	232	30	structure	structure	NN
cord-006788-kz8i4a6h	232	31	and	and	CC
cord-006788-kz8i4a6h	232	32	render	render	VB
cord-006788-kz8i4a6h	232	33	it	-PRON-	PRP
cord-006788-kz8i4a6h	232	34	susceptible	susceptible	JJ
cord-006788-kz8i4a6h	232	35	to	to	IN
cord-006788-kz8i4a6h	232	36	degradation	degradation	NN
cord-006788-kz8i4a6h	232	37	,	,	,
cord-006788-kz8i4a6h	232	38	thereby	thereby	RB
cord-006788-kz8i4a6h	232	39	resulting	result	VBG
cord-006788-kz8i4a6h	232	40	in	in	IN
cord-006788-kz8i4a6h	232	41	autosomal	autosomal	JJ
cord-006788-kz8i4a6h	232	42	recessive	recessive	JJ
cord-006788-kz8i4a6h	232	43	familial	familial	JJ
cord-006788-kz8i4a6h	232	44	tumoral	tumoral	NN
cord-006788-kz8i4a6h	232	45	calcinosis	calcinosis	NNP
cord-006788-kz8i4a6h	232	46	with	with	IN
cord-006788-kz8i4a6h	232	47	hyperphosphatemia	hyperphosphatemia	NNP
cord-006788-kz8i4a6h	232	48	[	[	-LRB-
cord-006788-kz8i4a6h	232	49	2	2	CD
cord-006788-kz8i4a6h	232	50	,	,	,
cord-006788-kz8i4a6h	232	51	5	5	CD
cord-006788-kz8i4a6h	232	52	,	,	,
cord-006788-kz8i4a6h	232	53	[	[	-LRB-
cord-006788-kz8i4a6h	232	54	181	181	CD
cord-006788-kz8i4a6h	232	55	]	]	-RRB-
cord-006788-kz8i4a6h	232	56	[	[	-LRB-
cord-006788-kz8i4a6h	232	57	182	182	CD
cord-006788-kz8i4a6h	232	58	]	]	-RRB-
cord-006788-kz8i4a6h	232	59	[	[	-LRB-
cord-006788-kz8i4a6h	232	60	183	183	CD
cord-006788-kz8i4a6h	232	61	]	]	-RRB-
cord-006788-kz8i4a6h	232	62	[	[	-LRB-
cord-006788-kz8i4a6h	232	63	184	184	CD
cord-006788-kz8i4a6h	232	64	]	]	-RRB-
cord-006788-kz8i4a6h	232	65	.	.	.
cord-006788-kz8i4a6h	233	1	Patients	patient	NNS
cord-006788-kz8i4a6h	233	2	with	with	IN
cord-006788-kz8i4a6h	233	3	CKD	CKD	NNP
cord-006788-kz8i4a6h	233	4	have	have	VBP
cord-006788-kz8i4a6h	233	5	increased	increase	VBN
cord-006788-kz8i4a6h	233	6	serum	serum	NN
cord-006788-kz8i4a6h	233	7	levels	level	NNS
cord-006788-kz8i4a6h	233	8	of	of	IN
cord-006788-kz8i4a6h	233	9	phosphate	phosphate	NN
cord-006788-kz8i4a6h	233	10	as	as	RB
cord-006788-kz8i4a6h	233	11	well	well	RB
cord-006788-kz8i4a6h	233	12	as	as	IN
cord-006788-kz8i4a6h	233	13	FGF23	fgf23	NN
cord-006788-kz8i4a6h	233	14	,	,	,
cord-006788-kz8i4a6h	233	15	which	which	WDT
cord-006788-kz8i4a6h	233	16	lead	lead	VBP
cord-006788-kz8i4a6h	233	17	to	to	IN
cord-006788-kz8i4a6h	233	18	increased	increase	VBN
cord-006788-kz8i4a6h	233	19	uptake	uptake	NN
cord-006788-kz8i4a6h	233	20	of	of	IN
cord-006788-kz8i4a6h	233	21	calcium	calcium	NN
cord-006788-kz8i4a6h	233	22	by	by	IN
cord-006788-kz8i4a6h	233	23	the	the	DT
cord-006788-kz8i4a6h	233	24	kidneys	kidney	NNS
cord-006788-kz8i4a6h	233	25	,	,	,
cord-006788-kz8i4a6h	233	26	resulting	result	VBG
cord-006788-kz8i4a6h	233	27	in	in	IN
cord-006788-kz8i4a6h	233	28	vascular	vascular	JJ
cord-006788-kz8i4a6h	233	29	calcification	calcification	NN
cord-006788-kz8i4a6h	233	30	.	.	.
cord-006788-kz8i4a6h	234	1	This	this	DT
cord-006788-kz8i4a6h	234	2	explains	explain	VBZ
cord-006788-kz8i4a6h	234	3	the	the	DT
cord-006788-kz8i4a6h	234	4	CVD	CVD	NNP
cord-006788-kz8i4a6h	234	5	complications	complication	NNS
cord-006788-kz8i4a6h	234	6	,	,	,
cord-006788-kz8i4a6h	234	7	such	such	JJ
cord-006788-kz8i4a6h	234	8	as	as	IN
cord-006788-kz8i4a6h	234	9	cardiac	cardiac	JJ
cord-006788-kz8i4a6h	234	10	hypertrophy	hypertrophy	NN
cord-006788-kz8i4a6h	234	11	and	and	CC
cord-006788-kz8i4a6h	234	12	congestive	congestive	JJ
cord-006788-kz8i4a6h	234	13	heart	heart	NN
cord-006788-kz8i4a6h	234	14	failure	failure	NN
cord-006788-kz8i4a6h	234	15	,	,	,
cord-006788-kz8i4a6h	234	16	in	in	IN
cord-006788-kz8i4a6h	234	17	patients	patient	NNS
cord-006788-kz8i4a6h	234	18	with	with	IN
cord-006788-kz8i4a6h	234	19	CKD	CKD	NNP
cord-006788-kz8i4a6h	234	20	[	[	-LRB-
cord-006788-kz8i4a6h	234	21	185	185	CD
cord-006788-kz8i4a6h	234	22	,	,	,
cord-006788-kz8i4a6h	234	23	186	186	CD
cord-006788-kz8i4a6h	234	24	]	]	-RRB-
cord-006788-kz8i4a6h	234	25	.	.	.
cord-006788-kz8i4a6h	235	1	The	the	DT
cord-006788-kz8i4a6h	235	2	inhibition	inhibition	NN
cord-006788-kz8i4a6h	235	3	of	of	IN
cord-006788-kz8i4a6h	235	4	FGF23	fgf23	NN
cord-006788-kz8i4a6h	235	5	or	or	CC
cord-006788-kz8i4a6h	235	6	its	-PRON-	PRP$
cord-006788-kz8i4a6h	235	7	axis	axis	NN
cord-006788-kz8i4a6h	235	8	could	could	MD
cord-006788-kz8i4a6h	235	9	be	be	VB
cord-006788-kz8i4a6h	235	10	a	a	DT
cord-006788-kz8i4a6h	235	11	strategy	strategy	NN
cord-006788-kz8i4a6h	235	12	to	to	TO
cord-006788-kz8i4a6h	235	13	bring	bring	VB
cord-006788-kz8i4a6h	235	14	CVD	CVD	NNP
cord-006788-kz8i4a6h	235	15	and	and	CC
cord-006788-kz8i4a6h	235	16	vascular	vascular	JJ
cord-006788-kz8i4a6h	235	17	calcification	calcification	NN
cord-006788-kz8i4a6h	235	18	under	under	IN
cord-006788-kz8i4a6h	235	19	control	control	NN
cord-006788-kz8i4a6h	235	20	.	.	.
cord-006788-kz8i4a6h	236	1	The	the	DT
cord-006788-kz8i4a6h	236	2	FGF23	fgf23	NN
cord-006788-kz8i4a6h	236	3	level	level	NN
cord-006788-kz8i4a6h	236	4	in	in	IN
cord-006788-kz8i4a6h	236	5	patients	patient	NNS
cord-006788-kz8i4a6h	236	6	with	with	IN
cord-006788-kz8i4a6h	236	7	CKD	CKD	NNP
cord-006788-kz8i4a6h	236	8	can	can	MD
cord-006788-kz8i4a6h	236	9	even	even	RB
cord-006788-kz8i4a6h	236	10	indicate	indicate	VB
cord-006788-kz8i4a6h	236	11	their	-PRON-	PRP$
cord-006788-kz8i4a6h	236	12	life	life	NN
cord-006788-kz8i4a6h	236	13	expectancy	expectancy	NN
cord-006788-kz8i4a6h	236	14	.	.	.
cord-006788-kz8i4a6h	237	1	The	the	DT
cord-006788-kz8i4a6h	237	2	dysregulation	dysregulation	NN
cord-006788-kz8i4a6h	237	3	of	of	IN
cord-006788-kz8i4a6h	237	4	calcium	calcium	NN
cord-006788-kz8i4a6h	237	5	levels	level	NNS
cord-006788-kz8i4a6h	237	6	can	can	MD
cord-006788-kz8i4a6h	237	7	have	have	VB
cord-006788-kz8i4a6h	237	8	an	an	DT
cord-006788-kz8i4a6h	237	9	array	array	NN
cord-006788-kz8i4a6h	237	10	of	of	IN
cord-006788-kz8i4a6h	237	11	serious	serious	JJ
cord-006788-kz8i4a6h	237	12	health	health	NN
cord-006788-kz8i4a6h	237	13	consequences	consequence	NNS
cord-006788-kz8i4a6h	237	14	.	.	.
cord-006788-kz8i4a6h	238	1	Chronic	chronic	JJ
cord-006788-kz8i4a6h	238	2	hypocalcemia	hypocalcemia	NN
cord-006788-kz8i4a6h	238	3	can	can	MD
cord-006788-kz8i4a6h	238	4	potentially	potentially	RB
cord-006788-kz8i4a6h	238	5	lead	lead	VB
cord-006788-kz8i4a6h	238	6	to	to	IN
cord-006788-kz8i4a6h	238	7	heart	heart	NN
cord-006788-kz8i4a6h	238	8	failure	failure	NN
cord-006788-kz8i4a6h	238	9	,	,	,
cord-006788-kz8i4a6h	238	10	nervous	nervous	JJ
cord-006788-kz8i4a6h	238	11	system	system	NN
cord-006788-kz8i4a6h	238	12	and	and	CC
cord-006788-kz8i4a6h	238	13	muscle	muscle	NN
cord-006788-kz8i4a6h	238	14	disorders	disorder	NNS
cord-006788-kz8i4a6h	238	15	,	,	,
cord-006788-kz8i4a6h	238	16	and	and	CC
cord-006788-kz8i4a6h	238	17	encephalopathy	encephalopathy	NN
cord-006788-kz8i4a6h	238	18	,	,	,
cord-006788-kz8i4a6h	238	19	while	while	IN
cord-006788-kz8i4a6h	238	20	hypercalcemia	hypercalcemia	NN
cord-006788-kz8i4a6h	238	21	can	can	MD
cord-006788-kz8i4a6h	238	22	increase	increase	VB
cord-006788-kz8i4a6h	238	23	the	the	DT
cord-006788-kz8i4a6h	238	24	risk	risk	NN
cord-006788-kz8i4a6h	238	25	of	of	IN
cord-006788-kz8i4a6h	238	26	kidney	kidney	NN
cord-006788-kz8i4a6h	238	27	stones	stone	NNS
cord-006788-kz8i4a6h	238	28	,	,	,
cord-006788-kz8i4a6h	238	29	cause	cause	VB
cord-006788-kz8i4a6h	238	30	muscle	muscle	NN
cord-006788-kz8i4a6h	238	31	weakness	weakness	NN
cord-006788-kz8i4a6h	238	32	,	,	,
cord-006788-kz8i4a6h	238	33	and	and	CC
cord-006788-kz8i4a6h	238	34	worsen	worsen	VB
cord-006788-kz8i4a6h	238	35	psychological	psychological	JJ
cord-006788-kz8i4a6h	238	36	issues	issue	NNS
cord-006788-kz8i4a6h	238	37	,	,	,
cord-006788-kz8i4a6h	238	38	such	such	JJ
cord-006788-kz8i4a6h	238	39	as	as	IN
cord-006788-kz8i4a6h	238	40	dementia	dementia	NN
cord-006788-kz8i4a6h	238	41	and	and	CC
cord-006788-kz8i4a6h	238	42	depression	depression	NN
cord-006788-kz8i4a6h	238	43	.	.	.
cord-006788-kz8i4a6h	239	1	This	this	DT
cord-006788-kz8i4a6h	239	2	may	may	MD
cord-006788-kz8i4a6h	239	3	explain	explain	VB
cord-006788-kz8i4a6h	239	4	some	some	DT
cord-006788-kz8i4a6h	239	5	current	current	JJ
cord-006788-kz8i4a6h	239	6	observations	observation	NNS
cord-006788-kz8i4a6h	239	7	that	that	WDT
cord-006788-kz8i4a6h	239	8	people	people	NNS
cord-006788-kz8i4a6h	239	9	with	with	IN
cord-006788-kz8i4a6h	239	10	high	high	JJ
cord-006788-kz8i4a6h	239	11	serum	serum	NN
cord-006788-kz8i4a6h	239	12	FGF23	fgf23	NN
cord-006788-kz8i4a6h	239	13	can	can	MD
cord-006788-kz8i4a6h	239	14	be	be	VB
cord-006788-kz8i4a6h	239	15	at	at	IN
cord-006788-kz8i4a6h	239	16	risk	risk	NN
cord-006788-kz8i4a6h	239	17	of	of	IN
cord-006788-kz8i4a6h	239	18	dementia	dementia	NN
cord-006788-kz8i4a6h	239	19	,	,	,
cord-006788-kz8i4a6h	239	20	and	and	CC
cord-006788-kz8i4a6h	239	21	that	that	IN
cord-006788-kz8i4a6h	239	22	mice	mouse	NNS
cord-006788-kz8i4a6h	239	23	lacking	lack	VBG
cord-006788-kz8i4a6h	239	24	FGF23	fgf23	CD
cord-006788-kz8i4a6h	239	25	exhibit	exhibit	NN
cord-006788-kz8i4a6h	239	26	defective	defective	JJ
cord-006788-kz8i4a6h	239	27	learning	learning	NN
cord-006788-kz8i4a6h	239	28	and	and	CC
cord-006788-kz8i4a6h	239	29	memory	memory	NN
cord-006788-kz8i4a6h	239	30	problems	problem	NNS
cord-006788-kz8i4a6h	239	31	similar	similar	JJ
cord-006788-kz8i4a6h	239	32	to	to	IN
cord-006788-kz8i4a6h	239	33	those	those	DT
cord-006788-kz8i4a6h	239	34	seen	see	VBN
cord-006788-kz8i4a6h	239	35	in	in	IN
cord-006788-kz8i4a6h	239	36	KL	kl	NN
cord-006788-kz8i4a6h	239	37	-	-	HYPH
cord-006788-kz8i4a6h	239	38	deficient	deficient	JJ
cord-006788-kz8i4a6h	239	39	mice	mouse	NNS
cord-006788-kz8i4a6h	239	40	[	[	-LRB-
cord-006788-kz8i4a6h	239	41	187	187	CD
cord-006788-kz8i4a6h	239	42	,	,	,
cord-006788-kz8i4a6h	239	43	188	188	CD
cord-006788-kz8i4a6h	239	44	]	]	-RRB-
cord-006788-kz8i4a6h	239	45	.	.	.
cord-006788-kz8i4a6h	240	1	The	the	DT
cord-006788-kz8i4a6h	240	2	three	three	CD
cord-006788-kz8i4a6h	240	3	members	member	NNS
cord-006788-kz8i4a6h	240	4	of	of	IN
cord-006788-kz8i4a6h	240	5	the	the	DT
cord-006788-kz8i4a6h	240	6	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	240	7	FGFs	fgf	NNS
cord-006788-kz8i4a6h	240	8	,	,	,
cord-006788-kz8i4a6h	240	9	including	include	VBG
cord-006788-kz8i4a6h	240	10	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	240	11	,	,	,
cord-006788-kz8i4a6h	240	12	21	21	CD
cord-006788-kz8i4a6h	240	13	,	,	,
cord-006788-kz8i4a6h	240	14	and	and	CC
cord-006788-kz8i4a6h	240	15	23	23	CD
cord-006788-kz8i4a6h	240	16	,	,	,
cord-006788-kz8i4a6h	240	17	share	share	VB
cord-006788-kz8i4a6h	240	18	a	a	DT
cord-006788-kz8i4a6h	240	19	conserved	conserve	VBN
cord-006788-kz8i4a6h	240	20	core	core	NN
cord-006788-kz8i4a6h	240	21	structure	structure	NN
cord-006788-kz8i4a6h	240	22	of	of	IN
cord-006788-kz8i4a6h	240	23	βtrefoil	βtrefoil	NNP
cord-006788-kz8i4a6h	240	24	fold	fold	VBP
cord-006788-kz8i4a6h	240	25	but	but	CC
cord-006788-kz8i4a6h	240	26	diverge	diverge	VBP
cord-006788-kz8i4a6h	240	27	in	in	IN
cord-006788-kz8i4a6h	240	28	functions	function	NNS
cord-006788-kz8i4a6h	240	29	from	from	IN
cord-006788-kz8i4a6h	240	30	other	other	JJ
cord-006788-kz8i4a6h	240	31	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	240	32	members	member	NNS
cord-006788-kz8i4a6h	240	33	of	of	IN
cord-006788-kz8i4a6h	240	34	the	the	DT
cord-006788-kz8i4a6h	240	35	FGF	FGF	NNP
cord-006788-kz8i4a6h	240	36	family	family	NN
cord-006788-kz8i4a6h	240	37	during	during	IN
cord-006788-kz8i4a6h	240	38	evolution	evolution	NN
cord-006788-kz8i4a6h	240	39	(	(	-LRB-
cord-006788-kz8i4a6h	240	40	Fig	Fig	NNP
cord-006788-kz8i4a6h	240	41	.	.	.
cord-006788-kz8i4a6h	240	42	1	1	CD
cord-006788-kz8i4a6h	240	43	)	)	-RRB-
cord-006788-kz8i4a6h	240	44	.	.	.
cord-006788-kz8i4a6h	241	1	These	these	DT
cord-006788-kz8i4a6h	241	2	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	241	3	FGFs	fgf	NNS
cord-006788-kz8i4a6h	241	4	acquire	acquire	VBP
cord-006788-kz8i4a6h	241	5	specific	specific	JJ
cord-006788-kz8i4a6h	241	6	structural	structural	JJ
cord-006788-kz8i4a6h	241	7	elements	element	NNS
cord-006788-kz8i4a6h	241	8	that	that	WDT
cord-006788-kz8i4a6h	241	9	endow	endow	VBP
cord-006788-kz8i4a6h	241	10	them	-PRON-	PRP
cord-006788-kz8i4a6h	241	11	with	with	IN
cord-006788-kz8i4a6h	241	12	abilities	ability	NNS
cord-006788-kz8i4a6h	241	13	to	to	TO
cord-006788-kz8i4a6h	241	14	function	function	VB
cord-006788-kz8i4a6h	241	15	via	via	IN
cord-006788-kz8i4a6h	241	16	an	an	DT
cord-006788-kz8i4a6h	241	17	endocrine	endocrine	JJ
cord-006788-kz8i4a6h	241	18	mode	mode	NN
cord-006788-kz8i4a6h	241	19	and	and	CC
cord-006788-kz8i4a6h	241	20	to	to	TO
cord-006788-kz8i4a6h	241	21	bind	bind	VB
cord-006788-kz8i4a6h	241	22	new	new	JJ
cord-006788-kz8i4a6h	241	23	accessory	accessory	JJ
cord-006788-kz8i4a6h	241	24	receptors	receptor	NNS
cord-006788-kz8i4a6h	241	25	that	that	WDT
cord-006788-kz8i4a6h	241	26	have	have	VBP
cord-006788-kz8i4a6h	241	27	strict	strict	JJ
cord-006788-kz8i4a6h	241	28	expression	expression	NN
cord-006788-kz8i4a6h	241	29	patterns	pattern	NNS
cord-006788-kz8i4a6h	241	30	in	in	IN
cord-006788-kz8i4a6h	241	31	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	241	32	tissues	tissue	NNS
cord-006788-kz8i4a6h	241	33	.	.	.
cord-006788-kz8i4a6h	242	1	Although	although	IN
cord-006788-kz8i4a6h	242	2	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	242	3	FGFs	fgf	NNS
cord-006788-kz8i4a6h	242	4	still	still	RB
cord-006788-kz8i4a6h	242	5	signal	signal	VB
cord-006788-kz8i4a6h	242	6	through	through	IN
cord-006788-kz8i4a6h	242	7	the	the	DT
cord-006788-kz8i4a6h	242	8	transmembrane	transmembrane	JJ
cord-006788-kz8i4a6h	242	9	FGFR	FGFR	NNP
cord-006788-kz8i4a6h	242	10	tyrosine	tyrosine	NN
cord-006788-kz8i4a6h	242	11	kinases	kinase	NNS
cord-006788-kz8i4a6h	242	12	as	as	IN
cord-006788-kz8i4a6h	242	13	the	the	DT
cord-006788-kz8i4a6h	242	14	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	242	15	FGFs	FGFs	NNPS
cord-006788-kz8i4a6h	242	16	,	,	,
cord-006788-kz8i4a6h	242	17	these	these	DT
cord-006788-kz8i4a6h	242	18	new	new	JJ
cord-006788-kz8i4a6h	242	19	properties	property	NNS
cord-006788-kz8i4a6h	242	20	divert	divert	VBP
cord-006788-kz8i4a6h	242	21	their	-PRON-	PRP$
cord-006788-kz8i4a6h	242	22	functions	function	NNS
cord-006788-kz8i4a6h	242	23	to	to	IN
cord-006788-kz8i4a6h	242	24	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	242	25	regulation	regulation	NN
cord-006788-kz8i4a6h	242	26	.	.	.
cord-006788-kz8i4a6h	243	1	As	as	IN
cord-006788-kz8i4a6h	243	2	such	such	JJ
cord-006788-kz8i4a6h	243	3	,	,	,
cord-006788-kz8i4a6h	243	4	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	243	5	,	,	,
cord-006788-kz8i4a6h	243	6	21	21	CD
cord-006788-kz8i4a6h	243	7	,	,	,
cord-006788-kz8i4a6h	243	8	and	and	CC
cord-006788-kz8i4a6h	243	9	23	23	CD
cord-006788-kz8i4a6h	243	10	drive	drive	VB
cord-006788-kz8i4a6h	243	11	a	a	DT
cord-006788-kz8i4a6h	243	12	wide	wide	JJ
cord-006788-kz8i4a6h	243	13	range	range	NN
cord-006788-kz8i4a6h	243	14	of	of	IN
cord-006788-kz8i4a6h	243	15	diverse	diverse	JJ
cord-006788-kz8i4a6h	243	16	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	243	17	axes	axis	NNS
cord-006788-kz8i4a6h	243	18	that	that	WDT
cord-006788-kz8i4a6h	243	19	function	function	VBP
cord-006788-kz8i4a6h	243	20	in	in	IN
cord-006788-kz8i4a6h	243	21	maintaining	maintain	VBG
cord-006788-kz8i4a6h	243	22	the	the	DT
cord-006788-kz8i4a6h	243	23	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	243	24	of	of	IN
cord-006788-kz8i4a6h	243	25	bile	bile	NN
cord-006788-kz8i4a6h	243	26	acids	acid	NNS
cord-006788-kz8i4a6h	243	27	,	,	,
cord-006788-kz8i4a6h	243	28	glucose	glucose	NN
cord-006788-kz8i4a6h	243	29	,	,	,
cord-006788-kz8i4a6h	243	30	lipids	lipid	NNS
cord-006788-kz8i4a6h	243	31	,	,	,
cord-006788-kz8i4a6h	243	32	energy	energy	NN
cord-006788-kz8i4a6h	243	33	,	,	,
cord-006788-kz8i4a6h	243	34	and	and	CC
cord-006788-kz8i4a6h	243	35	minerals	mineral	NNS
cord-006788-kz8i4a6h	243	36	;	;	,
cord-006788-kz8i4a6h	243	37	offsetting	offset	VBG
cord-006788-kz8i4a6h	243	38	detrimental	detrimental	JJ
cord-006788-kz8i4a6h	243	39	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	243	40	derangements	derangement	NNS
cord-006788-kz8i4a6h	243	41	;	;	:
cord-006788-kz8i4a6h	243	42	and	and	CC
cord-006788-kz8i4a6h	243	43	achieving	achieve	VBG
cord-006788-kz8i4a6h	243	44	optimal	optimal	JJ
cord-006788-kz8i4a6h	243	45	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	243	46	health	health	NN
cord-006788-kz8i4a6h	243	47	without	without	IN
cord-006788-kz8i4a6h	243	48	an	an	DT
cord-006788-kz8i4a6h	243	49	overt	overt	JJ
cord-006788-kz8i4a6h	243	50	effect	effect	NN
cord-006788-kz8i4a6h	243	51	on	on	IN
cord-006788-kz8i4a6h	243	52	cell	cell	NN
cord-006788-kz8i4a6h	243	53	proliferation	proliferation	NN
cord-006788-kz8i4a6h	243	54	and	and	CC
cord-006788-kz8i4a6h	243	55	population	population	NN
cord-006788-kz8i4a6h	243	56	growth	growth	NN
cord-006788-kz8i4a6h	243	57	.	.	.
cord-006788-kz8i4a6h	244	1	In	in	IN
cord-006788-kz8i4a6h	244	2	this	this	DT
cord-006788-kz8i4a6h	244	3	sense	sense	NN
cord-006788-kz8i4a6h	244	4	,	,	,
cord-006788-kz8i4a6h	244	5	each	each	DT
cord-006788-kz8i4a6h	244	6	of	of	IN
cord-006788-kz8i4a6h	244	7	the	the	DT
cord-006788-kz8i4a6h	244	8	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	244	9	axes	axis	NNS
cord-006788-kz8i4a6h	244	10	of	of	IN
cord-006788-kz8i4a6h	244	11	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	244	12	,	,	,
cord-006788-kz8i4a6h	244	13	21	21	CD
cord-006788-kz8i4a6h	244	14	,	,	,
cord-006788-kz8i4a6h	244	15	and	and	CC
cord-006788-kz8i4a6h	244	16	23	23	CD
cord-006788-kz8i4a6h	244	17	stands	stand	NNS
cord-006788-kz8i4a6h	244	18	alone	alone	JJ
cord-006788-kz8i4a6h	244	19	as	as	IN
cord-006788-kz8i4a6h	244	20	a	a	DT
cord-006788-kz8i4a6h	244	21	driver	driver	NN
cord-006788-kz8i4a6h	244	22	of	of	IN
cord-006788-kz8i4a6h	244	23	specific	specific	JJ
cord-006788-kz8i4a6h	244	24	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	244	25	effects	effect	NNS
cord-006788-kz8i4a6h	244	26	with	with	IN
cord-006788-kz8i4a6h	244	27	important	important	JJ
cord-006788-kz8i4a6h	244	28	physiological	physiological	JJ
cord-006788-kz8i4a6h	244	29	functions	function	NNS
cord-006788-kz8i4a6h	244	30	and	and	CC
cord-006788-kz8i4a6h	244	31	pathological	pathological	JJ
cord-006788-kz8i4a6h	244	32	consequences	consequence	NNS
cord-006788-kz8i4a6h	244	33	.	.	.
cord-006788-kz8i4a6h	245	1	Therefore	therefore	RB
cord-006788-kz8i4a6h	245	2	,	,	,
cord-006788-kz8i4a6h	245	3	these	these	DT
cord-006788-kz8i4a6h	245	4	axes	axis	NNS
cord-006788-kz8i4a6h	245	5	together	together	RB
cord-006788-kz8i4a6h	245	6	constitute	constitute	VBP
cord-006788-kz8i4a6h	245	7	the	the	DT
cord-006788-kz8i4a6h	245	8	"	"	``
cord-006788-kz8i4a6h	245	9	FGF	FGF	NNP
cord-006788-kz8i4a6h	245	10	Metabolic	Metabolic	NNP
cord-006788-kz8i4a6h	245	11	Axis	Axis	NNP
cord-006788-kz8i4a6h	245	12	,	,	,
cord-006788-kz8i4a6h	245	13	"	"	''
cord-006788-kz8i4a6h	245	14	which	which	WDT
cord-006788-kz8i4a6h	245	15	is	be	VBZ
cord-006788-kz8i4a6h	245	16	a	a	DT
cord-006788-kz8i4a6h	245	17	new	new	JJ
cord-006788-kz8i4a6h	245	18	term	term	NN
cord-006788-kz8i4a6h	245	19	that	that	WDT
cord-006788-kz8i4a6h	245	20	we	-PRON-	PRP
cord-006788-kz8i4a6h	245	21	start	start	VBP
cord-006788-kz8i4a6h	245	22	to	to	TO
cord-006788-kz8i4a6h	245	23	call	call	VB
cord-006788-kz8i4a6h	245	24	hereafter	hereafter	RB
cord-006788-kz8i4a6h	245	25	,	,	,
cord-006788-kz8i4a6h	245	26	with	with	IN
cord-006788-kz8i4a6h	245	27	broad	broad	JJ
cord-006788-kz8i4a6h	245	28	-	-	HYPH
cord-006788-kz8i4a6h	245	29	spectrum	spectrum	NN
cord-006788-kz8i4a6h	245	30	pathophysiological	pathophysiological	JJ
cord-006788-kz8i4a6h	245	31	roles	role	NNS
cord-006788-kz8i4a6h	245	32	and	and	CC
cord-006788-kz8i4a6h	245	33	consequences	consequence	NNS
cord-006788-kz8i4a6h	245	34	on	on	IN
cord-006788-kz8i4a6h	245	35	the	the	DT
cord-006788-kz8i4a6h	245	36	quality	quality	NN
cord-006788-kz8i4a6h	245	37	of	of	IN
cord-006788-kz8i4a6h	245	38	survival	survival	NN
cord-006788-kz8i4a6h	246	1	(	(	-LRB-
cord-006788-kz8i4a6h	246	2	Fig	Fig	NNP
cord-006788-kz8i4a6h	246	3	.	.	NNP
cord-006788-kz8i4a6h	246	4	1	1	CD
cord-006788-kz8i4a6h	246	5	)	)	-RRB-
cord-006788-kz8i4a6h	246	6	.	.	.
cord-006788-kz8i4a6h	247	1	I	-PRON-	PRP
cord-006788-kz8i4a6h	247	2	would	would	MD
cord-006788-kz8i4a6h	247	3	like	like	VB
cord-006788-kz8i4a6h	247	4	to	to	TO
cord-006788-kz8i4a6h	247	5	acknowledge	acknowledge	VB
cord-006788-kz8i4a6h	247	6	the	the	DT
cord-006788-kz8i4a6h	247	7	long	long	JJ
cord-006788-kz8i4a6h	247	8	-	-	HYPH
cord-006788-kz8i4a6h	247	9	term	term	NN
cord-006788-kz8i4a6h	247	10	contributions	contribution	NNS
cord-006788-kz8i4a6h	247	11	of	of	IN
cord-006788-kz8i4a6h	247	12	many	many	JJ
cord-006788-kz8i4a6h	247	13	members	member	NNS
cord-006788-kz8i4a6h	247	14	of	of	IN
cord-006788-kz8i4a6h	247	15	my	-PRON-	PRP$
cord-006788-kz8i4a6h	247	16	Wenzhou	Wenzhou	NNP
cord-006788-kz8i4a6h	247	17	FGF	FGF	NNP
cord-006788-kz8i4a6h	247	18	team	team	NN
cord-006788-kz8i4a6h	247	19	to	to	IN
cord-006788-kz8i4a6h	247	20	the	the	DT
cord-006788-kz8i4a6h	247	21	FGF	FGF	NNP
cord-006788-kz8i4a6h	247	22	field	field	NN
cord-006788-kz8i4a6h	247	23	research	research	NN
cord-006788-kz8i4a6h	247	24	as	as	IN
cord-006788-kz8i4a6h	247	25	I	-PRON-	PRP
cord-006788-kz8i4a6h	247	26	cited	cite	VBD
cord-006788-kz8i4a6h	247	27	in	in	IN
cord-006788-kz8i4a6h	247	28	the	the	DT
cord-006788-kz8i4a6h	247	29	text	text	NN
cord-006788-kz8i4a6h	247	30	that	that	WDT
cord-006788-kz8i4a6h	247	31	made	make	VBD
cord-006788-kz8i4a6h	247	32	the	the	DT
cord-006788-kz8i4a6h	247	33	idea	idea	NN
cord-006788-kz8i4a6h	247	34	of	of	IN
cord-006788-kz8i4a6h	247	35	"	"	``
cord-006788-kz8i4a6h	247	36	The	the	DT
cord-006788-kz8i4a6h	247	37	FGF	FGF	NNP
cord-006788-kz8i4a6h	247	38	Metabolic	Metabolic	NNP
cord-006788-kz8i4a6h	247	39	Axis	Axis	NNP
cord-006788-kz8i4a6h	247	40	"	"	''
cord-006788-kz8i4a6h	247	41	possible	possible	JJ
cord-006788-kz8i4a6h	247	42	.	.	.
cord-006788-kz8i4a6h	248	1	I	-PRON-	PRP
cord-006788-kz8i4a6h	248	2	thank	thank	VBP
cord-006788-kz8i4a6h	248	3	Dr.	Dr.	NNP
cord-006788-kz8i4a6h	248	4	Yongde	Yongde	NNP
cord-006788-kz8i4a6h	248	5	Luo	Luo	NNP
cord-006788-kz8i4a6h	248	6	for	for	IN
cord-006788-kz8i4a6h	248	7	the	the	DT
cord-006788-kz8i4a6h	248	8	expert	expert	JJ
cord-006788-kz8i4a6h	248	9	assistance	assistance	NN
cord-006788-kz8i4a6h	248	10	on	on	IN
cord-006788-kz8i4a6h	248	11	the	the	DT
cord-006788-kz8i4a6h	248	12	conceptual	conceptual	JJ
cord-006788-kz8i4a6h	248	13	and	and	CC
cord-006788-kz8i4a6h	248	14	practical	practical	JJ
cord-006788-kz8i4a6h	248	15	aspects	aspect	NNS
cord-006788-kz8i4a6h	248	16	of	of	IN
cord-006788-kz8i4a6h	248	17	the	the	DT
cord-006788-kz8i4a6h	248	18	manuscript	manuscript	NN
cord-006788-kz8i4a6h	248	19	and	and	CC
cord-006788-kz8i4a6h	248	20	Dr.	Dr.	NNP
cord-006788-kz8i4a6h	248	21	Jin	Jin	NNP
cord-006788-kz8i4a6h	248	22	-	-	HYPH
cord-006788-kz8i4a6h	248	23	San	San	NNP
cord-006788-kz8i4a6h	248	24	Zhang	Zhang	NNP
cord-006788-kz8i4a6h	248	25	and	and	CC
cord-006788-kz8i4a6h	248	26	Dr.	Dr.	NNP
cord-006788-kz8i4a6h	248	27	Jian	Jian	NNP
cord-006788-kz8i4a6h	248	28	Xiao	Xiao	NNP
cord-006788-kz8i4a6h	248	29	for	for	IN
cord-006788-kz8i4a6h	248	30	their	-PRON-	PRP$
cord-006788-kz8i4a6h	248	31	assistance	assistance	NN
cord-006788-kz8i4a6h	248	32	.	.	.
cord-006788-kz8i4a6h	249	1	I	-PRON-	PRP
cord-006788-kz8i4a6h	249	2	apologize	apologize	VBP
cord-006788-kz8i4a6h	249	3	to	to	IN
cord-006788-kz8i4a6h	249	4	those	those	DT
cord-006788-kz8i4a6h	249	5	whose	whose	WP$
cord-006788-kz8i4a6h	249	6	works	work	NNS
cord-006788-kz8i4a6h	249	7	have	have	VBP
cord-006788-kz8i4a6h	249	8	not	not	RB
cord-006788-kz8i4a6h	249	9	been	be	VBN
cord-006788-kz8i4a6h	249	10	cited	cite	VBN
cord-006788-kz8i4a6h	249	11	here	here	RB
cord-006788-kz8i4a6h	249	12	due	due	IN
cord-006788-kz8i4a6h	249	13	to	to	IN
cord-006788-kz8i4a6h	249	14	the	the	DT
cord-006788-kz8i4a6h	249	15	limited	limited	JJ
cord-006788-kz8i4a6h	249	16	discussion	discussion	NN
cord-006788-kz8i4a6h	249	17	scope	scope	NN
cord-006788-kz8i4a6h	249	18	on	on	IN
cord-006788-kz8i4a6h	249	19	this	this	DT
cord-006788-kz8i4a6h	249	20	evolving	evolve	VBG
cord-006788-kz8i4a6h	249	21	field	field	NN
cord-006788-kz8i4a6h	249	22	.	.	.
cord-006788-kz8i4a6h	250	1	This	this	DT
cord-006788-kz8i4a6h	250	2	work	work	NN
cord-006788-kz8i4a6h	250	3	is	be	VBZ
cord-006788-kz8i4a6h	250	4	supported	support	VBN
cord-006788-kz8i4a6h	250	5	by	by	IN
cord-006788-kz8i4a6h	250	6	the	the	DT
cord-006788-kz8i4a6h	250	7	National	National	NNP
cord-006788-kz8i4a6h	250	8	Key	Key	NNP
cord-006788-kz8i4a6h	250	9	R&D	R&D	NNP
cord-006788-kz8i4a6h	250	10	Program	Program	NNP
cord-006788-kz8i4a6h	250	11	of	of	IN
cord-006788-kz8i4a6h	250	12	China	China	NNP
cord-006788-kz8i4a6h	250	13	(	(	-LRB-
cord-006788-kz8i4a6h	250	14	No	no	NN
cord-006788-kz8i4a6h	250	15	.	.	NNP
cord-006788-kz8i4a6h	250	16	2017YFA0506000	2017yfa0506000	CD
cord-006788-kz8i4a6h	250	17	,	,	,
cord-006788-kz8i4a6h	250	18	Xiaokun	Xiaokun	NNP
cord-006788-kz8i4a6h	250	19	Li	Li	NNP
cord-006788-kz8i4a6h	250	20	)	)	-RRB-
cord-006788-kz8i4a6h	250	21	.	.	.
cord-006788-kz8i4a6h	251	1	Xiaokun	Xiaokun	NNP
cord-006788-kz8i4a6h	251	2	Li	Li	NNP
cord-006788-kz8i4a6h	251	3	declares	declare	VBZ
cord-006788-kz8i4a6h	251	4	no	no	DT
cord-006788-kz8i4a6h	251	5	conflict	conflict	NN
cord-006788-kz8i4a6h	251	6	of	of	IN
cord-006788-kz8i4a6h	251	7	interests	interest	NNS
cord-006788-kz8i4a6h	251	8	.	.	.
cord-006788-kz8i4a6h	252	1	This	this	DT
cord-006788-kz8i4a6h	252	2	manuscript	manuscript	NN
cord-006788-kz8i4a6h	252	3	is	be	VBZ
cord-006788-kz8i4a6h	252	4	a	a	DT
cord-006788-kz8i4a6h	252	5	review	review	NN
cord-006788-kz8i4a6h	252	6	article	article	NN
cord-006788-kz8i4a6h	252	7	and	and	CC
cord-006788-kz8i4a6h	252	8	does	do	VBZ
cord-006788-kz8i4a6h	252	9	not	not	RB
cord-006788-kz8i4a6h	252	10	involve	involve	VB
cord-006788-kz8i4a6h	252	11	a	a	DT
cord-006788-kz8i4a6h	252	12	research	research	NN
cord-006788-kz8i4a6h	252	13	protocol	protocol	NN
cord-006788-kz8i4a6h	252	14	requiring	require	VBG
cord-006788-kz8i4a6h	252	15	approval	approval	NN
cord-006788-kz8i4a6h	252	16	by	by	IN
cord-006788-kz8i4a6h	252	17	the	the	DT
cord-006788-kz8i4a6h	252	18	relevant	relevant	JJ
cord-006788-kz8i4a6h	252	19	institutional	institutional	JJ
cord-006788-kz8i4a6h	252	20	review	review	NN
cord-006788-kz8i4a6h	252	21	board	board	NNP
cord-006788-kz8i4a6h	252	22	or	or	CC
cord-006788-kz8i4a6h	252	23	ethics	ethics	NNP
cord-006788-kz8i4a6h	252	24	committee	committee	NNP
cord-006788-kz8i4a6h	252	25	.	.	.
cord-006788-kz8i4a6h	253	1	Open	open	VB
cord-006788-kz8i4a6h	253	2	Access	Access	NNP
cord-006788-kz8i4a6h	254	1	This	this	DT
cord-006788-kz8i4a6h	254	2	article	article	NN
cord-006788-kz8i4a6h	254	3	is	be	VBZ
cord-006788-kz8i4a6h	254	4	licensed	license	VBN
cord-006788-kz8i4a6h	254	5	under	under	IN
cord-006788-kz8i4a6h	254	6	a	a	DT
cord-006788-kz8i4a6h	254	7	Creative	Creative	NNP
cord-006788-kz8i4a6h	254	8	Commons	Commons	NNP
cord-006788-kz8i4a6h	254	9	Attribution	Attribution	NNP
cord-006788-kz8i4a6h	254	10	4.0	4.0	CD
cord-006788-kz8i4a6h	254	11	International	International	NNP
cord-006788-kz8i4a6h	254	12	License	License	NNP
cord-006788-kz8i4a6h	254	13	,	,	,
cord-006788-kz8i4a6h	254	14	which	which	WDT
cord-006788-kz8i4a6h	254	15	permits	permit	VBZ
cord-006788-kz8i4a6h	254	16	use	use	NN
cord-006788-kz8i4a6h	254	17	,	,	,
cord-006788-kz8i4a6h	254	18	sharing	sharing	NN
cord-006788-kz8i4a6h	254	19	,	,	,
cord-006788-kz8i4a6h	254	20	adaptation	adaptation	NN
cord-006788-kz8i4a6h	254	21	,	,	,
cord-006788-kz8i4a6h	254	22	distribution	distribution	NN
cord-006788-kz8i4a6h	254	23	and	and	CC
cord-006788-kz8i4a6h	254	24	reproduction	reproduction	NN
cord-006788-kz8i4a6h	254	25	in	in	IN
cord-006788-kz8i4a6h	254	26	any	any	DT
cord-006788-kz8i4a6h	254	27	medium	medium	NN
cord-006788-kz8i4a6h	254	28	or	or	CC
cord-006788-kz8i4a6h	254	29	format	format	NN
cord-006788-kz8i4a6h	254	30	,	,	,
cord-006788-kz8i4a6h	254	31	as	as	RB
cord-006788-kz8i4a6h	254	32	long	long	RB
cord-006788-kz8i4a6h	254	33	as	as	IN
cord-006788-kz8i4a6h	254	34	you	-PRON-	PRP
cord-006788-kz8i4a6h	254	35	give	give	VBP
cord-006788-kz8i4a6h	254	36	appropriate	appropriate	JJ
cord-006788-kz8i4a6h	254	37	credit	credit	NN
cord-006788-kz8i4a6h	254	38	to	to	IN
cord-006788-kz8i4a6h	254	39	the	the	DT
cord-006788-kz8i4a6h	254	40	original	original	JJ
cord-006788-kz8i4a6h	254	41	author(s	author(s	NNP
cord-006788-kz8i4a6h	254	42	)	)	-RRB-
cord-006788-kz8i4a6h	254	43	and	and	CC
cord-006788-kz8i4a6h	254	44	the	the	DT
cord-006788-kz8i4a6h	254	45	source	source	NN
cord-006788-kz8i4a6h	254	46	,	,	,
cord-006788-kz8i4a6h	254	47	provide	provide	VB
cord-006788-kz8i4a6h	254	48	a	a	DT
cord-006788-kz8i4a6h	254	49	link	link	NN
cord-006788-kz8i4a6h	254	50	to	to	IN
cord-006788-kz8i4a6h	254	51	the	the	DT
cord-006788-kz8i4a6h	254	52	Creative	Creative	NNP
cord-006788-kz8i4a6h	254	53	Commons	Commons	NNP
cord-006788-kz8i4a6h	254	54	licence	licence	NN
cord-006788-kz8i4a6h	254	55	,	,	,
cord-006788-kz8i4a6h	254	56	and	and	CC
cord-006788-kz8i4a6h	254	57	indicate	indicate	VBP
cord-006788-kz8i4a6h	254	58	if	if	IN
cord-006788-kz8i4a6h	254	59	changes	change	NNS
cord-006788-kz8i4a6h	254	60	were	be	VBD
cord-006788-kz8i4a6h	254	61	made	make	VBN
cord-006788-kz8i4a6h	254	62	.	.	.
cord-006788-kz8i4a6h	255	1	The	the	DT
cord-006788-kz8i4a6h	255	2	images	image	NNS
cord-006788-kz8i4a6h	255	3	or	or	CC
cord-006788-kz8i4a6h	255	4	other	other	JJ
cord-006788-kz8i4a6h	255	5	third	third	JJ
cord-006788-kz8i4a6h	255	6	party	party	NN
cord-006788-kz8i4a6h	255	7	material	material	NN
cord-006788-kz8i4a6h	255	8	in	in	IN
cord-006788-kz8i4a6h	255	9	this	this	DT
cord-006788-kz8i4a6h	255	10	article	article	NN
cord-006788-kz8i4a6h	255	11	are	be	VBP
cord-006788-kz8i4a6h	255	12	included	include	VBN
cord-006788-kz8i4a6h	255	13	in	in	IN
cord-006788-kz8i4a6h	255	14	the	the	DT
cord-006788-kz8i4a6h	255	15	article	article	NN
cord-006788-kz8i4a6h	255	16	's	's	POS
cord-006788-kz8i4a6h	255	17	Creative	Creative	NNP
cord-006788-kz8i4a6h	255	18	Commons	Commons	NNP
cord-006788-kz8i4a6h	255	19	licence	licence	NN
cord-006788-kz8i4a6h	255	20	,	,	,
cord-006788-kz8i4a6h	255	21	unless	unless	IN
cord-006788-kz8i4a6h	255	22	indicated	indicate	VBN
cord-006788-kz8i4a6h	255	23	otherwise	otherwise	RB
cord-006788-kz8i4a6h	255	24	in	in	IN
cord-006788-kz8i4a6h	255	25	a	a	DT
cord-006788-kz8i4a6h	255	26	credit	credit	NN
cord-006788-kz8i4a6h	255	27	line	line	NN
cord-006788-kz8i4a6h	255	28	to	to	IN
cord-006788-kz8i4a6h	255	29	the	the	DT
cord-006788-kz8i4a6h	255	30	material	material	NN
cord-006788-kz8i4a6h	255	31	.	.	.
cord-006788-kz8i4a6h	256	1	If	if	IN
cord-006788-kz8i4a6h	256	2	material	material	NN
cord-006788-kz8i4a6h	256	3	is	be	VBZ
cord-006788-kz8i4a6h	256	4	not	not	RB
cord-006788-kz8i4a6h	256	5	included	include	VBN
cord-006788-kz8i4a6h	256	6	in	in	IN
cord-006788-kz8i4a6h	256	7	the	the	DT
cord-006788-kz8i4a6h	256	8	article	article	NN
cord-006788-kz8i4a6h	256	9	's	's	POS
cord-006788-kz8i4a6h	256	10	Creative	Creative	NNP
cord-006788-kz8i4a6h	256	11	Commons	Commons	NNP
cord-006788-kz8i4a6h	256	12	licence	licence	NN
cord-006788-kz8i4a6h	256	13	and	and	CC
cord-006788-kz8i4a6h	256	14	your	-PRON-	PRP$
cord-006788-kz8i4a6h	256	15	intended	intend	VBN
cord-006788-kz8i4a6h	256	16	use	use	NN
cord-006788-kz8i4a6h	256	17	is	be	VBZ
cord-006788-kz8i4a6h	256	18	not	not	RB
cord-006788-kz8i4a6h	256	19	permitted	permit	VBN
cord-006788-kz8i4a6h	256	20	by	by	IN
cord-006788-kz8i4a6h	256	21	statutory	statutory	JJ
cord-006788-kz8i4a6h	256	22	regulation	regulation	NN
cord-006788-kz8i4a6h	256	23	or	or	CC
cord-006788-kz8i4a6h	256	24	exceeds	exceed	VBZ
cord-006788-kz8i4a6h	256	25	the	the	DT
cord-006788-kz8i4a6h	256	26	permitted	permit	VBN
cord-006788-kz8i4a6h	256	27	use	use	NN
cord-006788-kz8i4a6h	256	28	,	,	,
cord-006788-kz8i4a6h	256	29	you	-PRON-	PRP
cord-006788-kz8i4a6h	256	30	will	will	MD
cord-006788-kz8i4a6h	256	31	need	need	VB
cord-006788-kz8i4a6h	256	32	to	to	TO
cord-006788-kz8i4a6h	256	33	obtain	obtain	VB
cord-006788-kz8i4a6h	256	34	permission	permission	NN
cord-006788-kz8i4a6h	256	35	directly	directly	RB
cord-006788-kz8i4a6h	256	36	from	from	IN
cord-006788-kz8i4a6h	256	37	the	the	DT
cord-006788-kz8i4a6h	256	38	copyright	copyright	NN
cord-006788-kz8i4a6h	256	39	holder	holder	NN
cord-006788-kz8i4a6h	256	40	.	.	.
cord-006788-kz8i4a6h	257	1	To	to	TO
cord-006788-kz8i4a6h	257	2	view	view	VB
cord-006788-kz8i4a6h	257	3	a	a	DT
cord-006788-kz8i4a6h	257	4	copy	copy	NN
cord-006788-kz8i4a6h	257	5	of	of	IN
cord-006788-kz8i4a6h	257	6	this	this	DT
cord-006788-kz8i4a6h	257	7	licence	licence	NN
cord-006788-kz8i4a6h	257	8	,	,	,
cord-006788-kz8i4a6h	257	9	visit	visit	VB
cord-006788-kz8i4a6h	257	10	https://creativecommons.org/	https://creativecommons.org/	ADD
cord-006788-kz8i4a6h	257	11	licenses/	licenses/	ADD
cord-006788-kz8i4a6h	258	1	by/4.0/.	by/4.0/.	NNP
cord-006788-kz8i4a6h	258	2	 	 	_SP
cord-006788-kz8i4a6h	259	1	The	the	DT
cord-006788-kz8i4a6h	259	2	FGF	FGF	NNP
cord-006788-kz8i4a6h	259	3	family	family	NN
cord-006788-kz8i4a6h	259	4	:	:	:
cord-006788-kz8i4a6h	259	5	biology	biology	NN
cord-006788-kz8i4a6h	259	6	,	,	,
cord-006788-kz8i4a6h	259	7	pathophysiology	pathophysiology	NN
cord-006788-kz8i4a6h	259	8	and	and	CC
cord-006788-kz8i4a6h	259	9	therapy	therapy	NN
cord-006788-kz8i4a6h	259	10	Emerging	emerge	VBG
cord-006788-kz8i4a6h	259	11	structure	structure	NN
cord-006788-kz8i4a6h	259	12	-	-	HYPH
cord-006788-kz8i4a6h	259	13	function	function	NN
cord-006788-kz8i4a6h	259	14	paradigm	paradigm	NN
cord-006788-kz8i4a6h	259	15	of	of	IN
cord-006788-kz8i4a6h	259	16	endocrine	endocrine	JJ
cord-006788-kz8i4a6h	259	17	FGFs	fgf	NNS
cord-006788-kz8i4a6h	259	18	in	in	IN
cord-006788-kz8i4a6h	259	19	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	259	20	diseases	disease	NNS
cord-006788-kz8i4a6h	259	21	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	259	22	growth	growth	NN
cord-006788-kz8i4a6h	259	23	factors	factor	NNS
cord-006788-kz8i4a6h	259	24	,	,	,
cord-006788-kz8i4a6h	259	25	old	old	JJ
cord-006788-kz8i4a6h	259	26	kids	kid	NNS
cord-006788-kz8i4a6h	259	27	on	on	IN
cord-006788-kz8i4a6h	259	28	the	the	DT
cord-006788-kz8i4a6h	259	29	new	new	JJ
cord-006788-kz8i4a6h	259	30	block	block	NN
cord-006788-kz8i4a6h	260	1	Threedimensional	threedimensional	JJ
cord-006788-kz8i4a6h	260	2	structure	structure	NN
cord-006788-kz8i4a6h	260	3	of	of	IN
cord-006788-kz8i4a6h	260	4	human	human	JJ
cord-006788-kz8i4a6h	260	5	basic	basic	JJ
cord-006788-kz8i4a6h	260	6	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	260	7	growth	growth	NN
cord-006788-kz8i4a6h	260	8	factor	factor	NN
cord-006788-kz8i4a6h	261	1	Comparative	comparative	JJ
cord-006788-kz8i4a6h	261	2	study	study	NN
cord-006788-kz8i4a6h	261	3	of	of	IN
cord-006788-kz8i4a6h	261	4	heparinpoloxamer	heparinpoloxamer	NNP
cord-006788-kz8i4a6h	261	5	hydrogel	hydrogel	NNP
cord-006788-kz8i4a6h	261	6	modified	modify	VBN
cord-006788-kz8i4a6h	261	7	bFGF	bFGF	NNP
cord-006788-kz8i4a6h	261	8	and	and	CC
cord-006788-kz8i4a6h	261	9	aFGF	afgf	VB
cord-006788-kz8i4a6h	261	10	for	for	IN
cord-006788-kz8i4a6h	261	11	in	in	IN
cord-006788-kz8i4a6h	261	12	vivo	vivo	NN
cord-006788-kz8i4a6h	261	13	wound	wind	VBN
cord-006788-kz8i4a6h	261	14	healing	heal	VBG
cord-006788-kz8i4a6h	261	15	efficiency	efficiency	NN
cord-006788-kz8i4a6h	262	1	Heparin	Heparin	NNP
cord-006788-kz8i4a6h	262	2	-	-	HYPH
cord-006788-kz8i4a6h	262	3	based	base	VBN
cord-006788-kz8i4a6h	262	4	coacervate	coacervate	NN
cord-006788-kz8i4a6h	262	5	of	of	IN
cord-006788-kz8i4a6h	262	6	FGF2	FGF2	NNP
cord-006788-kz8i4a6h	262	7	improves	improve	VBZ
cord-006788-kz8i4a6h	262	8	dermal	dermal	JJ
cord-006788-kz8i4a6h	262	9	regeneration	regeneration	NN
cord-006788-kz8i4a6h	262	10	by	by	IN
cord-006788-kz8i4a6h	262	11	asserting	assert	VBG
cord-006788-kz8i4a6h	262	12	a	a	DT
cord-006788-kz8i4a6h	262	13	synergistic	synergistic	JJ
cord-006788-kz8i4a6h	262	14	role	role	NN
cord-006788-kz8i4a6h	262	15	with	with	IN
cord-006788-kz8i4a6h	262	16	cell	cell	NN
cord-006788-kz8i4a6h	262	17	proliferation	proliferation	NN
cord-006788-kz8i4a6h	262	18	and	and	CC
cord-006788-kz8i4a6h	262	19	endogenous	endogenous	JJ
cord-006788-kz8i4a6h	262	20	facilitated	facilitate	VBN
cord-006788-kz8i4a6h	262	21	VEGF	VEGF	NNP
cord-006788-kz8i4a6h	262	22	for	for	IN
cord-006788-kz8i4a6h	262	23	cutaneous	cutaneous	JJ
cord-006788-kz8i4a6h	262	24	wound	wound	NN
cord-006788-kz8i4a6h	262	25	healing	heal	VBG
cord-006788-kz8i4a6h	262	26	A	a	DT
cord-006788-kz8i4a6h	262	27	thermosensitive	thermosensitive	JJ
cord-006788-kz8i4a6h	262	28	heparin	heparin	NN
cord-006788-kz8i4a6h	262	29	-	-	HYPH
cord-006788-kz8i4a6h	262	30	poloxamer	poloxamer	NNP
cord-006788-kz8i4a6h	262	31	hydrogel	hydrogel	NN
cord-006788-kz8i4a6h	262	32	bridges	bridge	NNS
cord-006788-kz8i4a6h	262	33	aFGF	afgf	XX
cord-006788-kz8i4a6h	262	34	to	to	TO
cord-006788-kz8i4a6h	262	35	treat	treat	VB
cord-006788-kz8i4a6h	262	36	spinal	spinal	JJ
cord-006788-kz8i4a6h	262	37	cord	cord	NN
cord-006788-kz8i4a6h	262	38	injury	injury	NN
cord-006788-kz8i4a6h	262	39	Therapeutics	Therapeutics	NNP
cord-006788-kz8i4a6h	262	40	targeting	target	VBG
cord-006788-kz8i4a6h	262	41	FGF	FGF	NNP
cord-006788-kz8i4a6h	262	42	signaling	signal	VBG
cord-006788-kz8i4a6h	262	43	network	network	NN
cord-006788-kz8i4a6h	262	44	in	in	IN
cord-006788-kz8i4a6h	262	45	human	human	JJ
cord-006788-kz8i4a6h	262	46	diseases	disease	NNS
cord-006788-kz8i4a6h	263	1	Anticancer	anticancer	JJ
cord-006788-kz8i4a6h	263	2	molecules	molecule	NNS
cord-006788-kz8i4a6h	263	3	targeting	target	VBG
cord-006788-kz8i4a6h	263	4	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	263	5	growth	growth	NN
cord-006788-kz8i4a6h	263	6	factor	factor	NN
cord-006788-kz8i4a6h	263	7	receptors	receptor	NNS
cord-006788-kz8i4a6h	263	8	Hypotensive	hypotensive	JJ
cord-006788-kz8i4a6h	263	9	activity	activity	NN
cord-006788-kz8i4a6h	263	10	of	of	IN
cord-006788-kz8i4a6h	263	11	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	263	12	growth	growth	NN
cord-006788-kz8i4a6h	263	13	factor	factor	NN
cord-006788-kz8i4a6h	264	1	Fibroblast	fibroblast	JJ
cord-006788-kz8i4a6h	264	2	growth	growth	NN
cord-006788-kz8i4a6h	264	3	factor-16	factor-16	NN
cord-006788-kz8i4a6h	264	4	is	be	VBZ
cord-006788-kz8i4a6h	264	5	a	a	DT
cord-006788-kz8i4a6h	264	6	growth	growth	NN
cord-006788-kz8i4a6h	264	7	factor	factor	NN
cord-006788-kz8i4a6h	264	8	for	for	IN
cord-006788-kz8i4a6h	264	9	embryonic	embryonic	JJ
cord-006788-kz8i4a6h	264	10	brown	brown	JJ
cord-006788-kz8i4a6h	264	11	adipocytes	adipocyte	NNS
cord-006788-kz8i4a6h	265	1	In	in	IN
cord-006788-kz8i4a6h	265	2	vitro	vitro	FW
cord-006788-kz8i4a6h	265	3	and	and	CC
cord-006788-kz8i4a6h	265	4	in	in	IN
cord-006788-kz8i4a6h	265	5	vivo	vivo	NN
cord-006788-kz8i4a6h	265	6	analyses	analysis	NNS
cord-006788-kz8i4a6h	265	7	reveal	reveal	VBP
cord-006788-kz8i4a6h	265	8	profound	profound	JJ
cord-006788-kz8i4a6h	265	9	effects	effect	NNS
cord-006788-kz8i4a6h	265	10	of	of	IN
cord-006788-kz8i4a6h	265	11	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	265	12	growth	growth	NN
cord-006788-kz8i4a6h	265	13	factor	factor	NN
cord-006788-kz8i4a6h	265	14	16	16	CD
cord-006788-kz8i4a6h	265	15	as	as	IN
cord-006788-kz8i4a6h	265	16	a	a	DT
cord-006788-kz8i4a6h	265	17	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	265	18	regulator	regulator	NN
cord-006788-kz8i4a6h	265	19	A	A	NNP
cord-006788-kz8i4a6h	265	20	PPARg	PPARg	NNS
cord-006788-kz8i4a6h	265	21	-	-	:
cord-006788-kz8i4a6h	265	22	FGF1	FGF1	NNP
cord-006788-kz8i4a6h	265	23	axis	axis	NN
cord-006788-kz8i4a6h	265	24	is	be	VBZ
cord-006788-kz8i4a6h	265	25	required	require	VBN
cord-006788-kz8i4a6h	265	26	for	for	IN
cord-006788-kz8i4a6h	265	27	adaptive	adaptive	JJ
cord-006788-kz8i4a6h	265	28	adipose	adipose	JJ
cord-006788-kz8i4a6h	265	29	remodelling	remodelling	NN
cord-006788-kz8i4a6h	265	30	and	and	CC
cord-006788-kz8i4a6h	265	31	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	265	32	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	265	33	Uncoupling	uncouple	VBG
cord-006788-kz8i4a6h	265	34	the	the	DT
cord-006788-kz8i4a6h	265	35	mitogenic	mitogenic	NNP
cord-006788-kz8i4a6h	265	36	and	and	CC
cord-006788-kz8i4a6h	265	37	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	265	38	functions	function	NNS
cord-006788-kz8i4a6h	265	39	of	of	IN
cord-006788-kz8i4a6h	265	40	FGF1	FGF1	NNP
cord-006788-kz8i4a6h	265	41	by	by	IN
cord-006788-kz8i4a6h	265	42	tuning	tune	VBG
cord-006788-kz8i4a6h	265	43	FGF1-FGF	FGF1-FGF	NNP
cord-006788-kz8i4a6h	265	44	receptor	receptor	NN
cord-006788-kz8i4a6h	265	45	dimer	dimer	NN
cord-006788-kz8i4a6h	265	46	stability	stability	NN
cord-006788-kz8i4a6h	265	47	Maratos	Maratos	NNP
cord-006788-kz8i4a6h	265	48	-	-	HYPH
cord-006788-kz8i4a6h	265	49	Flier	Flier	NNP
cord-006788-kz8i4a6h	265	50	E.	E.	NNP
cord-006788-kz8i4a6h	265	51	Hepatic	hepatic	JJ
cord-006788-kz8i4a6h	265	52	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	265	53	growth	growth	NN
cord-006788-kz8i4a6h	265	54	factor	factor	NN
cord-006788-kz8i4a6h	265	55	21	21	CD
cord-006788-kz8i4a6h	265	56	is	be	VBZ
cord-006788-kz8i4a6h	265	57	regulated	regulate	VBN
cord-006788-kz8i4a6h	265	58	by	by	IN
cord-006788-kz8i4a6h	265	59	PPARα	PPARα	NNS
cord-006788-kz8i4a6h	265	60	and	and	CC
cord-006788-kz8i4a6h	265	61	is	be	VBZ
cord-006788-kz8i4a6h	265	62	a	a	DT
cord-006788-kz8i4a6h	265	63	key	key	JJ
cord-006788-kz8i4a6h	265	64	mediator	mediator	NN
cord-006788-kz8i4a6h	265	65	of	of	IN
cord-006788-kz8i4a6h	265	66	hepatic	hepatic	JJ
cord-006788-kz8i4a6h	265	67	lipid	lipid	NN
cord-006788-kz8i4a6h	265	68	metabolism	metabolism	NN
cord-006788-kz8i4a6h	265	69	in	in	IN
cord-006788-kz8i4a6h	265	70	ketotic	ketotic	JJ
cord-006788-kz8i4a6h	265	71	states	state	NNS
cord-006788-kz8i4a6h	265	72	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	265	73	growth	growth	NN
cord-006788-kz8i4a6h	265	74	factor	factor	NN
cord-006788-kz8i4a6h	265	75	15	15	CD
cord-006788-kz8i4a6h	265	76	functions	function	NNS
cord-006788-kz8i4a6h	265	77	as	as	IN
cord-006788-kz8i4a6h	265	78	an	an	DT
cord-006788-kz8i4a6h	265	79	enterohepatic	enterohepatic	JJ
cord-006788-kz8i4a6h	265	80	signal	signal	NN
cord-006788-kz8i4a6h	265	81	to	to	TO
cord-006788-kz8i4a6h	265	82	regulate	regulate	VB
cord-006788-kz8i4a6h	265	83	bile	bile	NN
cord-006788-kz8i4a6h	265	84	acid	acid	NN
cord-006788-kz8i4a6h	265	85	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	265	86	Endocrine	endocrine	JJ
cord-006788-kz8i4a6h	265	87	regulation	regulation	NN
cord-006788-kz8i4a6h	265	88	of	of	IN
cord-006788-kz8i4a6h	265	89	the	the	DT
cord-006788-kz8i4a6h	265	90	fasting	fast	VBG
cord-006788-kz8i4a6h	265	91	response	response	NN
cord-006788-kz8i4a6h	265	92	by	by	IN
cord-006788-kz8i4a6h	265	93	PPARα	PPARα	NNS
cord-006788-kz8i4a6h	265	94	-	-	HYPH
cord-006788-kz8i4a6h	265	95	mediated	mediate	VBN
cord-006788-kz8i4a6h	265	96	induction	induction	NN
cord-006788-kz8i4a6h	265	97	of	of	IN
cord-006788-kz8i4a6h	265	98	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	265	99	growth	growth	NN
cord-006788-kz8i4a6h	265	100	factor	factor	NN
cord-006788-kz8i4a6h	265	101	21	21	CD
cord-006788-kz8i4a6h	265	102	FGF-21	FGF-21	NNP
cord-006788-kz8i4a6h	265	103	as	as	IN
cord-006788-kz8i4a6h	265	104	a	a	DT
cord-006788-kz8i4a6h	265	105	novel	novel	JJ
cord-006788-kz8i4a6h	265	106	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	265	107	regulator	regulator	NN
cord-006788-kz8i4a6h	265	108	Klotho	Klotho	NNP
cord-006788-kz8i4a6h	265	109	co	co	NNS
cord-006788-kz8i4a6h	265	110	-	-	NNS
cord-006788-kz8i4a6h	265	111	receptors	receptor	NNS
cord-006788-kz8i4a6h	265	112	inhibit	inhibit	VBP
cord-006788-kz8i4a6h	265	113	signaling	signal	VBG
cord-006788-kz8i4a6h	265	114	by	by	IN
cord-006788-kz8i4a6h	265	115	paracrine	paracrine	JJ
cord-006788-kz8i4a6h	265	116	FGF8	FGF8	NNP
cord-006788-kz8i4a6h	265	117	subfamily	subfamily	NN
cord-006788-kz8i4a6h	265	118	ligands	ligand	NNS
cord-006788-kz8i4a6h	265	119	Metabolic	metabolic	JJ
cord-006788-kz8i4a6h	265	120	regulator	regulator	NN
cord-006788-kz8i4a6h	265	121	βKlotho	βKlotho	NNP
cord-006788-kz8i4a6h	265	122	interacts	interact	VBZ
cord-006788-kz8i4a6h	265	123	with	with	IN
cord-006788-kz8i4a6h	265	124	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	265	125	growth	growth	NN
cord-006788-kz8i4a6h	265	126	factor	factor	NN
cord-006788-kz8i4a6h	265	127	receptor	receptor	NN
cord-006788-kz8i4a6h	265	128	4	4	CD
cord-006788-kz8i4a6h	265	129	(	(	-LRB-
cord-006788-kz8i4a6h	265	130	FGFR4	FGFR4	NNP
cord-006788-kz8i4a6h	265	131	)	)	-RRB-
cord-006788-kz8i4a6h	265	132	to	to	TO
cord-006788-kz8i4a6h	265	133	induce	induce	VB
cord-006788-kz8i4a6h	265	134	apoptosis	apoptosis	NN
cord-006788-kz8i4a6h	265	135	and	and	CC
cord-006788-kz8i4a6h	265	136	inhibit	inhibit	VB
cord-006788-kz8i4a6h	265	137	tumor	tumor	NN
cord-006788-kz8i4a6h	265	138	cell	cell	NN
cord-006788-kz8i4a6h	265	139	proliferation	proliferation	NN
cord-006788-kz8i4a6h	265	140	Evolutionary	evolutionary	JJ
cord-006788-kz8i4a6h	265	141	history	history	NN
cord-006788-kz8i4a6h	265	142	and	and	CC
cord-006788-kz8i4a6h	265	143	functional	functional	JJ
cord-006788-kz8i4a6h	265	144	implications	implication	NNS
cord-006788-kz8i4a6h	265	145	of	of	IN
cord-006788-kz8i4a6h	265	146	protein	protein	NN
cord-006788-kz8i4a6h	265	147	domains	domain	NNS
cord-006788-kz8i4a6h	265	148	and	and	CC
cord-006788-kz8i4a6h	265	149	their	-PRON-	PRP$
cord-006788-kz8i4a6h	265	150	combinations	combination	NNS
cord-006788-kz8i4a6h	265	151	in	in	IN
cord-006788-kz8i4a6h	265	152	eukaryotes	eukaryote	NNS
cord-006788-kz8i4a6h	265	153	Tissue	tissue	NN
cord-006788-kz8i4a6h	265	154	-	-	HYPH
cord-006788-kz8i4a6h	265	155	specific	specific	JJ
cord-006788-kz8i4a6h	265	156	expression	expression	NN
cord-006788-kz8i4a6h	265	157	of	of	IN
cord-006788-kz8i4a6h	265	158	βKlotho	βKlotho	NNP
cord-006788-kz8i4a6h	265	159	and	and	CC
cord-006788-kz8i4a6h	265	160	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	265	161	growth	growth	NN
cord-006788-kz8i4a6h	265	162	factor	factor	NN
cord-006788-kz8i4a6h	265	163	(	(	-LRB-
cord-006788-kz8i4a6h	265	164	FGF	FGF	NNP
cord-006788-kz8i4a6h	265	165	)	)	-RRB-
cord-006788-kz8i4a6h	265	166	receptor	receptor	NN
cord-006788-kz8i4a6h	265	167	isoforms	isoform	NNS
cord-006788-kz8i4a6h	265	168	determines	determine	VBZ
cord-006788-kz8i4a6h	265	169	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	265	170	activity	activity	NN
cord-006788-kz8i4a6h	265	171	of	of	IN
cord-006788-kz8i4a6h	265	172	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	265	173	and	and	CC
cord-006788-kz8i4a6h	265	174	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	265	175	Research	Research	NNP
cord-006788-kz8i4a6h	265	176	resource	resource	NN
cord-006788-kz8i4a6h	265	177	:	:	:
cord-006788-kz8i4a6h	265	178	comprehensive	comprehensive	JJ
cord-006788-kz8i4a6h	265	179	expression	expression	NN
cord-006788-kz8i4a6h	265	180	atlas	atlas	NN
cord-006788-kz8i4a6h	265	181	of	of	IN
cord-006788-kz8i4a6h	265	182	the	the	DT
cord-006788-kz8i4a6h	265	183	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	265	184	growth	growth	NN
cord-006788-kz8i4a6h	265	185	factor	factor	NN
cord-006788-kz8i4a6h	265	186	system	system	NN
cord-006788-kz8i4a6h	265	187	in	in	IN
cord-006788-kz8i4a6h	265	188	adult	adult	NN
cord-006788-kz8i4a6h	265	189	mouse	mouse	NN
cord-006788-kz8i4a6h	265	190	Identification	identification	NN
cord-006788-kz8i4a6h	265	191	of	of	IN
cord-006788-kz8i4a6h	265	192	a	a	DT
cord-006788-kz8i4a6h	265	193	domain	domain	NN
cord-006788-kz8i4a6h	265	194	within	within	IN
cord-006788-kz8i4a6h	265	195	peroxisome	peroxisome	NN
cord-006788-kz8i4a6h	265	196	proliferator	proliferator	NN
cord-006788-kz8i4a6h	265	197	-	-	HYPH
cord-006788-kz8i4a6h	265	198	activated	activate	VBN
cord-006788-kz8i4a6h	265	199	receptor	receptor	NN
cord-006788-kz8i4a6h	265	200	γ	γ	NN
cord-006788-kz8i4a6h	265	201	regulating	regulate	VBG
cord-006788-kz8i4a6h	265	202	expression	expression	NN
cord-006788-kz8i4a6h	265	203	of	of	IN
cord-006788-kz8i4a6h	265	204	a	a	DT
cord-006788-kz8i4a6h	265	205	group	group	NN
cord-006788-kz8i4a6h	265	206	of	of	IN
cord-006788-kz8i4a6h	265	207	genes	gene	NNS
cord-006788-kz8i4a6h	265	208	containing	contain	VBG
cord-006788-kz8i4a6h	265	209	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	265	210	growth	growth	NN
cord-006788-kz8i4a6h	265	211	factor	factor	NN
cord-006788-kz8i4a6h	265	212	21	21	CD
cord-006788-kz8i4a6h	265	213	that	that	WDT
cord-006788-kz8i4a6h	265	214	are	be	VBP
cord-006788-kz8i4a6h	265	215	selectively	selectively	RB
cord-006788-kz8i4a6h	265	216	repressed	repress	VBN
cord-006788-kz8i4a6h	265	217	by	by	IN
cord-006788-kz8i4a6h	265	218	SIRT1	SIRT1	NNS
cord-006788-kz8i4a6h	265	219	in	in	IN
cord-006788-kz8i4a6h	265	220	adipocytes	adipocyte	NNS
cord-006788-kz8i4a6h	265	221	Glucose	Glucose	NNP
cord-006788-kz8i4a6h	265	222	induces	induce	VBZ
cord-006788-kz8i4a6h	265	223	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	265	224	mRNA	mrna	NN
cord-006788-kz8i4a6h	265	225	expression	expression	NN
cord-006788-kz8i4a6h	265	226	through	through	IN
cord-006788-kz8i4a6h	265	227	ChREBP	ChREBP	NNP
cord-006788-kz8i4a6h	265	228	activation	activation	NN
cord-006788-kz8i4a6h	265	229	in	in	IN
cord-006788-kz8i4a6h	265	230	rat	rat	NN
cord-006788-kz8i4a6h	265	231	hepatocytes	hepatocyte	NNS
cord-006788-kz8i4a6h	265	232	Regulation	Regulation	NNP
cord-006788-kz8i4a6h	265	233	of	of	IN
cord-006788-kz8i4a6h	265	234	FGF21	fgf21	JJ
cord-006788-kz8i4a6h	265	235	expression	expression	NN
cord-006788-kz8i4a6h	265	236	and	and	CC
cord-006788-kz8i4a6h	265	237	secretion	secretion	NN
cord-006788-kz8i4a6h	265	238	by	by	IN
cord-006788-kz8i4a6h	265	239	retinoic	retinoic	JJ
cord-006788-kz8i4a6h	265	240	acid	acid	NN
cord-006788-kz8i4a6h	265	241	receptor	receptor	NN
cord-006788-kz8i4a6h	265	242	-	-	HYPH
cord-006788-kz8i4a6h	265	243	related	relate	VBN
cord-006788-kz8i4a6h	265	244	orphan	orphan	NN
cord-006788-kz8i4a6h	265	245	receptor	receptor	NN
cord-006788-kz8i4a6h	265	246	α	α	NN
cord-006788-kz8i4a6h	266	1	Liver	liver	NN
cord-006788-kz8i4a6h	266	2	X	x	NN
cord-006788-kz8i4a6h	266	3	receptor	receptor	NN
cord-006788-kz8i4a6h	266	4	negatively	negatively	RB
cord-006788-kz8i4a6h	266	5	regulates	regulate	VBZ
cord-006788-kz8i4a6h	266	6	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	266	7	growth	growth	NN
cord-006788-kz8i4a6h	266	8	factor	factor	NN
cord-006788-kz8i4a6h	266	9	21	21	CD
cord-006788-kz8i4a6h	266	10	in	in	IN
cord-006788-kz8i4a6h	266	11	the	the	DT
cord-006788-kz8i4a6h	266	12	fatty	fatty	JJ
cord-006788-kz8i4a6h	266	13	liver	liver	NN
cord-006788-kz8i4a6h	266	14	induced	induce	VBN
cord-006788-kz8i4a6h	266	15	by	by	IN
cord-006788-kz8i4a6h	266	16	cholesterol	cholesterol	NN
cord-006788-kz8i4a6h	266	17	-	-	HYPH
cord-006788-kz8i4a6h	266	18	enriched	enrich	VBN
cord-006788-kz8i4a6h	266	19	diet	diet	NN
cord-006788-kz8i4a6h	266	20	Vitamin	vitamin	NN
cord-006788-kz8i4a6h	266	21	D	d	NN
cord-006788-kz8i4a6h	266	22	receptor	receptor	NN
cord-006788-kz8i4a6h	266	23	in	in	IN
cord-006788-kz8i4a6h	266	24	chondrocytes	chondrocyte	NNS
cord-006788-kz8i4a6h	267	1	promotes	promote	VBZ
cord-006788-kz8i4a6h	267	2	osteoclastogenesis	osteoclastogenesis	NNP
cord-006788-kz8i4a6h	267	3	and	and	CC
cord-006788-kz8i4a6h	267	4	regulates	regulate	VBZ
cord-006788-kz8i4a6h	267	5	FGF23	fgf23	NN
cord-006788-kz8i4a6h	267	6	production	production	NN
cord-006788-kz8i4a6h	267	7	in	in	IN
cord-006788-kz8i4a6h	267	8	osteoblasts	osteoblast	NNS
cord-006788-kz8i4a6h	268	1	25-Dihydroxyvitamin	25-dihydroxyvitamin	CD
cord-006788-kz8i4a6h	268	2	D3	D3	NNP
cord-006788-kz8i4a6h	268	3	upregulates	upregulate	VBZ
cord-006788-kz8i4a6h	268	4	FGF23	fgf23	NN
cord-006788-kz8i4a6h	268	5	gene	gene	NN
cord-006788-kz8i4a6h	268	6	expression	expression	NN
cord-006788-kz8i4a6h	268	7	in	in	IN
cord-006788-kz8i4a6h	268	8	bone	bone	NN
cord-006788-kz8i4a6h	268	9	:	:	:
cord-006788-kz8i4a6h	268	10	the	the	DT
cord-006788-kz8i4a6h	268	11	final	final	JJ
cord-006788-kz8i4a6h	268	12	link	link	NN
cord-006788-kz8i4a6h	268	13	in	in	IN
cord-006788-kz8i4a6h	268	14	a	a	DT
cord-006788-kz8i4a6h	268	15	renal	renal	JJ
cord-006788-kz8i4a6h	268	16	-	-	HYPH
cord-006788-kz8i4a6h	268	17	gastrointestinal	gastrointestinal	JJ
cord-006788-kz8i4a6h	268	18	-	-	HYPH
cord-006788-kz8i4a6h	268	19	skeletal	skeletal	JJ
cord-006788-kz8i4a6h	268	20	axis	axis	NN
cord-006788-kz8i4a6h	268	21	that	that	WDT
cord-006788-kz8i4a6h	268	22	controls	control	VBZ
cord-006788-kz8i4a6h	268	23	phosphate	phosphate	NN
cord-006788-kz8i4a6h	268	24	transport	transport	NN
cord-006788-kz8i4a6h	269	1	The	the	DT
cord-006788-kz8i4a6h	269	2	link	link	NN
cord-006788-kz8i4a6h	269	3	between	between	IN
cord-006788-kz8i4a6h	269	4	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	269	5	growth	growth	NN
cord-006788-kz8i4a6h	269	6	factor	factor	NN
cord-006788-kz8i4a6h	269	7	21	21	CD
cord-006788-kz8i4a6h	269	8	and	and	CC
cord-006788-kz8i4a6h	269	9	sterol	sterol	NN
cord-006788-kz8i4a6h	269	10	regulatory	regulatory	JJ
cord-006788-kz8i4a6h	269	11	element	element	NN
cord-006788-kz8i4a6h	269	12	binding	bind	VBG
cord-006788-kz8i4a6h	269	13	protein	protein	NN
cord-006788-kz8i4a6h	269	14	1c	1c	NN
cord-006788-kz8i4a6h	269	15	during	during	IN
cord-006788-kz8i4a6h	269	16	lipogenesis	lipogenesi	NNS
cord-006788-kz8i4a6h	269	17	in	in	IN
cord-006788-kz8i4a6h	269	18	hepatocytes	hepatocyte	NNS
cord-006788-kz8i4a6h	269	19	Ablation	ablation	NN
cord-006788-kz8i4a6h	269	20	of	of	IN
cord-006788-kz8i4a6h	269	21	gp78	gp78	NN
cord-006788-kz8i4a6h	269	22	in	in	IN
cord-006788-kz8i4a6h	269	23	liver	liver	NN
cord-006788-kz8i4a6h	269	24	improves	improve	VBZ
cord-006788-kz8i4a6h	269	25	hyperlipidemia	hyperlipidemia	NN
cord-006788-kz8i4a6h	269	26	and	and	CC
cord-006788-kz8i4a6h	269	27	insulin	insulin	NN
cord-006788-kz8i4a6h	269	28	resistance	resistance	NN
cord-006788-kz8i4a6h	269	29	by	by	IN
cord-006788-kz8i4a6h	269	30	inhibiting	inhibit	VBG
cord-006788-kz8i4a6h	269	31	SREBP	SREBP	NNP
cord-006788-kz8i4a6h	269	32	to	to	TO
cord-006788-kz8i4a6h	269	33	decrease	decrease	VB
cord-006788-kz8i4a6h	269	34	lipid	lipid	NN
cord-006788-kz8i4a6h	269	35	biosynthesis	biosynthesis	NN
cord-006788-kz8i4a6h	269	36	Adipose	adipose	JJ
cord-006788-kz8i4a6h	269	37	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	269	38	growth	growth	NN
cord-006788-kz8i4a6h	269	39	factor	factor	NN
cord-006788-kz8i4a6h	269	40	21	21	CD
cord-006788-kz8i4a6h	269	41	is	be	VBZ
cord-006788-kz8i4a6h	269	42	up	up	RB
cord-006788-kz8i4a6h	269	43	-	-	HYPH
cord-006788-kz8i4a6h	269	44	regulated	regulate	VBN
cord-006788-kz8i4a6h	269	45	by	by	IN
cord-006788-kz8i4a6h	269	46	peroxisome	peroxisome	NN
cord-006788-kz8i4a6h	269	47	proliferatoractivated	proliferatoractivated	JJ
cord-006788-kz8i4a6h	269	48	receptor	receptor	NN
cord-006788-kz8i4a6h	269	49	γ	γ	NN
cord-006788-kz8i4a6h	269	50	and	and	CC
cord-006788-kz8i4a6h	269	51	altered	alter	VBD
cord-006788-kz8i4a6h	269	52	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	269	53	states	state	NNS
cord-006788-kz8i4a6h	269	54	Activating	activate	VBG
cord-006788-kz8i4a6h	269	55	transcription	transcription	NN
cord-006788-kz8i4a6h	269	56	factor	factor	NN
cord-006788-kz8i4a6h	269	57	4-dependent	4-dependent	CD
cord-006788-kz8i4a6h	269	58	induction	induction	NN
cord-006788-kz8i4a6h	269	59	of	of	IN
cord-006788-kz8i4a6h	269	60	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	269	61	during	during	IN
cord-006788-kz8i4a6h	269	62	amino	amino	NN
cord-006788-kz8i4a6h	269	63	acid	acid	NN
cord-006788-kz8i4a6h	269	64	deprivation	deprivation	NN
cord-006788-kz8i4a6h	269	65	Differential	differential	NN
cord-006788-kz8i4a6h	269	66	specificity	specificity	NN
cord-006788-kz8i4a6h	269	67	of	of	IN
cord-006788-kz8i4a6h	269	68	endocrine	endocrine	NN
cord-006788-kz8i4a6h	269	69	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	269	70	and	and	CC
cord-006788-kz8i4a6h	269	71	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	269	72	to	to	IN
cord-006788-kz8i4a6h	269	73	FGFR1	FGFR1	NNP
cord-006788-kz8i4a6h	269	74	and	and	CC
cord-006788-kz8i4a6h	269	75	FGFR4	FGFR4	NNP
cord-006788-kz8i4a6h	269	76	in	in	IN
cord-006788-kz8i4a6h	269	77	complex	complex	NN
cord-006788-kz8i4a6h	269	78	with	with	IN
cord-006788-kz8i4a6h	269	79	KLB	KLB	NNP
cord-006788-kz8i4a6h	269	80	Structures	Structures	NNPS
cord-006788-kz8i4a6h	269	81	of	of	IN
cord-006788-kz8i4a6h	269	82	β	β	NNP
cord-006788-kz8i4a6h	269	83	-	-	HYPH
cord-006788-kz8i4a6h	269	84	klotho	klotho	NNP
cord-006788-kz8i4a6h	269	85	reveal	reveal	VB
cord-006788-kz8i4a6h	269	86	a	a	DT
cord-006788-kz8i4a6h	269	87	'	'	``
cord-006788-kz8i4a6h	269	88	zip	zip	NN
cord-006788-kz8i4a6h	269	89	code'-like	code'-like	NNP
cord-006788-kz8i4a6h	269	90	mechanism	mechanism	NN
cord-006788-kz8i4a6h	269	91	for	for	IN
cord-006788-kz8i4a6h	269	92	endocrine	endocrine	JJ
cord-006788-kz8i4a6h	269	93	FGF	FGF	NNP
cord-006788-kz8i4a6h	269	94	signalling	signal	VBG
cord-006788-kz8i4a6h	269	95	Stressed	stress	VBD
cord-006788-kz8i4a6h	269	96	liver	liver	NN
cord-006788-kz8i4a6h	269	97	and	and	CC
cord-006788-kz8i4a6h	269	98	muscle	muscle	NN
cord-006788-kz8i4a6h	269	99	call	call	NN
cord-006788-kz8i4a6h	269	100	on	on	IN
cord-006788-kz8i4a6h	269	101	adipocytes	adipocyte	NNS
cord-006788-kz8i4a6h	269	102	with	with	IN
cord-006788-kz8i4a6h	269	103	FGF21	fgf21	NN
cord-006788-kz8i4a6h	269	104	NGM282	NGM282	NNPS
cord-006788-kz8i4a6h	269	105	for	for	IN
cord-006788-kz8i4a6h	269	106	treatment	treatment	NN
cord-006788-kz8i4a6h	269	107	of	of	IN
cord-006788-kz8i4a6h	269	108	nonalcoholic	nonalcoholic	JJ
cord-006788-kz8i4a6h	269	109	steatohepatitis	steatohepatitis	NNP
cord-006788-kz8i4a6h	269	110	:	:	:
cord-006788-kz8i4a6h	269	111	a	a	DT
cord-006788-kz8i4a6h	269	112	multicentre	multicentre	NNP
cord-006788-kz8i4a6h	269	113	,	,	,
cord-006788-kz8i4a6h	269	114	randomised	randomised	JJ
cord-006788-kz8i4a6h	269	115	,	,	,
cord-006788-kz8i4a6h	269	116	double	double	JJ
cord-006788-kz8i4a6h	269	117	-	-	HYPH
cord-006788-kz8i4a6h	269	118	blind	blind	JJ
cord-006788-kz8i4a6h	269	119	,	,	,
cord-006788-kz8i4a6h	269	120	placebo	placebo	NN
cord-006788-kz8i4a6h	269	121	-	-	HYPH
cord-006788-kz8i4a6h	269	122	controlled	control	VBN
cord-006788-kz8i4a6h	269	123	,	,	,
cord-006788-kz8i4a6h	269	124	phase	phase	NN
cord-006788-kz8i4a6h	269	125	2	2	CD
cord-006788-kz8i4a6h	269	126	trial	trial	NN
cord-006788-kz8i4a6h	269	127	Effect	effect	NN
cord-006788-kz8i4a6h	269	128	of	of	IN
cord-006788-kz8i4a6h	269	129	NGM282	NGM282	NNPS
cord-006788-kz8i4a6h	269	130	,	,	,
cord-006788-kz8i4a6h	269	131	an	an	DT
cord-006788-kz8i4a6h	269	132	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	269	133	analogue	analogue	NN
cord-006788-kz8i4a6h	269	134	,	,	,
cord-006788-kz8i4a6h	269	135	in	in	IN
cord-006788-kz8i4a6h	269	136	primary	primary	JJ
cord-006788-kz8i4a6h	269	137	sclerosing	sclerosing	NN
cord-006788-kz8i4a6h	269	138	cholangitis	cholangitis	NN
cord-006788-kz8i4a6h	269	139	:	:	:
cord-006788-kz8i4a6h	269	140	a	a	DT
cord-006788-kz8i4a6h	269	141	multicenter	multicenter	NN
cord-006788-kz8i4a6h	269	142	,	,	,
cord-006788-kz8i4a6h	269	143	randomized	randomized	JJ
cord-006788-kz8i4a6h	269	144	,	,	,
cord-006788-kz8i4a6h	269	145	double	double	JJ
cord-006788-kz8i4a6h	269	146	-	-	HYPH
cord-006788-kz8i4a6h	269	147	blind	blind	JJ
cord-006788-kz8i4a6h	269	148	,	,	,
cord-006788-kz8i4a6h	269	149	placebo	placebo	NN
cord-006788-kz8i4a6h	269	150	-	-	HYPH
cord-006788-kz8i4a6h	269	151	controlled	control	VBN
cord-006788-kz8i4a6h	269	152	phase	phase	NN
cord-006788-kz8i4a6h	269	153	II	ii	CD
cord-006788-kz8i4a6h	269	154	trial	trial	NN
cord-006788-kz8i4a6h	269	155	NGM282	NGM282	NNPS
cord-006788-kz8i4a6h	269	156	improves	improve	VBZ
cord-006788-kz8i4a6h	269	157	liver	liver	NN
cord-006788-kz8i4a6h	269	158	fibrosis	fibrosis	NN
cord-006788-kz8i4a6h	269	159	and	and	CC
cord-006788-kz8i4a6h	269	160	histology	histology	NN
cord-006788-kz8i4a6h	269	161	in	in	IN
cord-006788-kz8i4a6h	269	162	12	12	CD
cord-006788-kz8i4a6h	269	163	weeks	week	NNS
cord-006788-kz8i4a6h	269	164	in	in	IN
cord-006788-kz8i4a6h	269	165	patients	patient	NNS
cord-006788-kz8i4a6h	269	166	with	with	IN
cord-006788-kz8i4a6h	269	167	nonalcoholic	nonalcoholic	JJ
cord-006788-kz8i4a6h	269	168	steatohepatitis	steatohepatitis	NNP
cord-006788-kz8i4a6h	269	169	BMS-986036	BMS-986036	NNP
cord-006788-kz8i4a6h	269	170	)	)	-RRB-
cord-006788-kz8i4a6h	269	171	,	,	,
cord-006788-kz8i4a6h	269	172	a	a	DT
cord-006788-kz8i4a6h	269	173	PEGylated	pegylate	VBN
cord-006788-kz8i4a6h	269	174	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	269	175	growth	growth	NN
cord-006788-kz8i4a6h	269	176	factor	factor	NN
cord-006788-kz8i4a6h	269	177	21	21	CD
cord-006788-kz8i4a6h	269	178	analogue	analogue	NN
cord-006788-kz8i4a6h	269	179	,	,	,
cord-006788-kz8i4a6h	269	180	in	in	IN
cord-006788-kz8i4a6h	269	181	patients	patient	NNS
cord-006788-kz8i4a6h	269	182	with	with	IN
cord-006788-kz8i4a6h	269	183	non	non	JJ
cord-006788-kz8i4a6h	269	184	-	-	JJ
cord-006788-kz8i4a6h	269	185	alcoholic	alcoholic	JJ
cord-006788-kz8i4a6h	269	186	steatohepatitis	steatohepatitis	NN
cord-006788-kz8i4a6h	269	187	:	:	:
cord-006788-kz8i4a6h	269	188	a	a	DT
cord-006788-kz8i4a6h	269	189	randomised	randomised	JJ
cord-006788-kz8i4a6h	269	190	,	,	,
cord-006788-kz8i4a6h	269	191	doubleblind	doubleblind	NN
cord-006788-kz8i4a6h	269	192	,	,	,
cord-006788-kz8i4a6h	269	193	placebo	placebo	NN
cord-006788-kz8i4a6h	269	194	-	-	HYPH
cord-006788-kz8i4a6h	269	195	controlled	control	VBN
cord-006788-kz8i4a6h	269	196	,	,	,
cord-006788-kz8i4a6h	269	197	phase	phase	NN
cord-006788-kz8i4a6h	269	198	2a	2a	CD
cord-006788-kz8i4a6h	269	199	trial	trial	NN
cord-006788-kz8i4a6h	270	1	A	a	DT
cord-006788-kz8i4a6h	270	2	long	long	RB
cord-006788-kz8i4a6h	270	3	-	-	HYPH
cord-006788-kz8i4a6h	270	4	acting	act	VBG
cord-006788-kz8i4a6h	270	5	FGF21	fgf21	JJ
cord-006788-kz8i4a6h	270	6	molecule	molecule	NN
cord-006788-kz8i4a6h	270	7	,	,	,
cord-006788-kz8i4a6h	270	8	PF-05231023	PF-05231023	NNP
cord-006788-kz8i4a6h	270	9	,	,	,
cord-006788-kz8i4a6h	270	10	decreases	decrease	VBZ
cord-006788-kz8i4a6h	270	11	body	body	NN
cord-006788-kz8i4a6h	270	12	weight	weight	NN
cord-006788-kz8i4a6h	270	13	and	and	CC
cord-006788-kz8i4a6h	270	14	improves	improve	VBZ
cord-006788-kz8i4a6h	270	15	lipid	lipid	NN
cord-006788-kz8i4a6h	270	16	profile	profile	NN
cord-006788-kz8i4a6h	270	17	in	in	IN
cord-006788-kz8i4a6h	270	18	non	non	JJ
cord-006788-kz8i4a6h	270	19	-	-	JJ
cord-006788-kz8i4a6h	270	20	human	human	JJ
cord-006788-kz8i4a6h	270	21	primates	primate	NNS
cord-006788-kz8i4a6h	270	22	and	and	CC
cord-006788-kz8i4a6h	270	23	type	type	NN
cord-006788-kz8i4a6h	270	24	2	2	CD
cord-006788-kz8i4a6h	270	25	diabetic	diabetic	JJ
cord-006788-kz8i4a6h	270	26	subjects	subject	NNS
cord-006788-kz8i4a6h	270	27	Randomized	randomized	JJ
cord-006788-kz8i4a6h	270	28	trial	trial	NN
cord-006788-kz8i4a6h	270	29	of	of	IN
cord-006788-kz8i4a6h	270	30	the	the	DT
cord-006788-kz8i4a6h	270	31	anti	anti	JJ
cord-006788-kz8i4a6h	270	32	-	-	JJ
cord-006788-kz8i4a6h	270	33	FGF23	fgf23	JJ
cord-006788-kz8i4a6h	270	34	antibody	antibody	NN
cord-006788-kz8i4a6h	270	35	KRN23	KRN23	NNP
cord-006788-kz8i4a6h	270	36	in	in	IN
cord-006788-kz8i4a6h	270	37	X	x	NN
cord-006788-kz8i4a6h	270	38	-	-	HYPH
cord-006788-kz8i4a6h	270	39	linked	link	VBN
cord-006788-kz8i4a6h	270	40	hypophosphatemia	hypophosphatemia	NN
cord-006788-kz8i4a6h	270	41	Elevated	elevated	JJ
cord-006788-kz8i4a6h	270	42	cholesterol	cholesterol	NN
cord-006788-kz8i4a6h	270	43	metabolism	metabolism	NN
cord-006788-kz8i4a6h	270	44	and	and	CC
cord-006788-kz8i4a6h	270	45	bile	bile	NN
cord-006788-kz8i4a6h	270	46	acid	acid	NN
cord-006788-kz8i4a6h	270	47	synthesis	synthesis	NN
cord-006788-kz8i4a6h	270	48	in	in	IN
cord-006788-kz8i4a6h	270	49	mice	mouse	NNS
cord-006788-kz8i4a6h	270	50	lacking	lack	VBG
cord-006788-kz8i4a6h	270	51	membrane	membrane	NN
cord-006788-kz8i4a6h	270	52	tyrosine	tyrosine	NN
cord-006788-kz8i4a6h	270	53	kinase	kinase	NN
cord-006788-kz8i4a6h	270	54	receptor	receptor	NN
cord-006788-kz8i4a6h	270	55	FGFR4	fgfr4	NN
cord-006788-kz8i4a6h	270	56	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	270	57	growth	growth	NN
cord-006788-kz8i4a6h	270	58	factor	factor	NN
cord-006788-kz8i4a6h	270	59	19	19	CD
cord-006788-kz8i4a6h	270	60	increases	increase	VBZ
cord-006788-kz8i4a6h	270	61	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	270	62	rate	rate	NN
cord-006788-kz8i4a6h	270	63	and	and	CC
cord-006788-kz8i4a6h	270	64	reverses	reverse	VBZ
cord-006788-kz8i4a6h	270	65	dietary	dietary	JJ
cord-006788-kz8i4a6h	270	66	and	and	CC
cord-006788-kz8i4a6h	270	67	leptin	leptin	NN
cord-006788-kz8i4a6h	270	68	-	-	HYPH
cord-006788-kz8i4a6h	270	69	deficient	deficient	JJ
cord-006788-kz8i4a6h	270	70	diabetes	diabetes	NN
cord-006788-kz8i4a6h	271	1	Transgenic	transgenic	JJ
cord-006788-kz8i4a6h	271	2	mice	mouse	NNS
cord-006788-kz8i4a6h	271	3	expressing	express	VBG
cord-006788-kz8i4a6h	271	4	human	human	JJ
cord-006788-kz8i4a6h	271	5	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	271	6	growth	growth	NN
cord-006788-kz8i4a6h	271	7	factor-19	factor-19	NNP
cord-006788-kz8i4a6h	271	8	display	display	NN
cord-006788-kz8i4a6h	271	9	increased	increase	VBN
cord-006788-kz8i4a6h	271	10	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	271	11	rate	rate	NN
cord-006788-kz8i4a6h	271	12	and	and	CC
cord-006788-kz8i4a6h	271	13	decreased	decrease	VBD
cord-006788-kz8i4a6h	271	14	adiposity	adiposity	NN
cord-006788-kz8i4a6h	271	15	The	the	DT
cord-006788-kz8i4a6h	271	16	breadth	breadth	NN
cord-006788-kz8i4a6h	271	17	of	of	IN
cord-006788-kz8i4a6h	271	18	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	271	19	's	's	POS
cord-006788-kz8i4a6h	271	20	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	271	21	actions	action	NNS
cord-006788-kz8i4a6h	271	22	are	be	VBP
cord-006788-kz8i4a6h	271	23	governed	govern	VBN
cord-006788-kz8i4a6h	271	24	by	by	IN
cord-006788-kz8i4a6h	271	25	FGFR1	FGFR1	NNP
cord-006788-kz8i4a6h	271	26	in	in	IN
cord-006788-kz8i4a6h	271	27	adipose	adipose	JJ
cord-006788-kz8i4a6h	271	28	tissue	tissue	NN
cord-006788-kz8i4a6h	272	1	A	a	DT
cord-006788-kz8i4a6h	272	2	new	new	JJ
cord-006788-kz8i4a6h	272	3	mechanism	mechanism	NN
cord-006788-kz8i4a6h	272	4	for	for	IN
cord-006788-kz8i4a6h	272	5	bile	bile	NN
cord-006788-kz8i4a6h	272	6	acid	acid	NN
cord-006788-kz8i4a6h	272	7	diarrhea	diarrhea	NN
cord-006788-kz8i4a6h	272	8	:	:	:
cord-006788-kz8i4a6h	272	9	defective	defective	JJ
cord-006788-kz8i4a6h	272	10	feedback	feedback	NN
cord-006788-kz8i4a6h	272	11	inhibition	inhibition	NN
cord-006788-kz8i4a6h	272	12	of	of	IN
cord-006788-kz8i4a6h	272	13	bile	bile	NN
cord-006788-kz8i4a6h	272	14	acid	acid	NN
cord-006788-kz8i4a6h	272	15	biosynthesis	biosynthesis	NN
cord-006788-kz8i4a6h	272	16	Effects	effect	NNS
cord-006788-kz8i4a6h	272	17	of	of	IN
cord-006788-kz8i4a6h	272	18	NGM282	NGM282	NNPS
cord-006788-kz8i4a6h	272	19	,	,	,
cord-006788-kz8i4a6h	272	20	an	an	DT
cord-006788-kz8i4a6h	272	21	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	272	22	variant	variant	NN
cord-006788-kz8i4a6h	272	23	,	,	,
cord-006788-kz8i4a6h	272	24	on	on	IN
cord-006788-kz8i4a6h	272	25	colonic	colonic	JJ
cord-006788-kz8i4a6h	272	26	transit	transit	NN
cord-006788-kz8i4a6h	272	27	and	and	CC
cord-006788-kz8i4a6h	272	28	bowel	bowel	NN
cord-006788-kz8i4a6h	272	29	function	function	NN
cord-006788-kz8i4a6h	272	30	in	in	IN
cord-006788-kz8i4a6h	272	31	functional	functional	JJ
cord-006788-kz8i4a6h	272	32	constipation	constipation	NN
cord-006788-kz8i4a6h	272	33	:	:	:
cord-006788-kz8i4a6h	272	34	a	a	DT
cord-006788-kz8i4a6h	272	35	randomized	randomized	JJ
cord-006788-kz8i4a6h	272	36	phase	phase	NN
cord-006788-kz8i4a6h	272	37	2	2	CD
cord-006788-kz8i4a6h	272	38	trial	trial	NN
cord-006788-kz8i4a6h	272	39	Antibodymediated	Antibodymediated	NNP
cord-006788-kz8i4a6h	272	40	inhibition	inhibition	NN
cord-006788-kz8i4a6h	272	41	of	of	IN
cord-006788-kz8i4a6h	272	42	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	272	43	growth	growth	NN
cord-006788-kz8i4a6h	272	44	factor	factor	NN
cord-006788-kz8i4a6h	272	45	19	19	CD
cord-006788-kz8i4a6h	272	46	results	result	NNS
cord-006788-kz8i4a6h	272	47	in	in	IN
cord-006788-kz8i4a6h	272	48	increased	increase	VBN
cord-006788-kz8i4a6h	272	49	bile	bile	NN
cord-006788-kz8i4a6h	272	50	acids	acid	NNS
cord-006788-kz8i4a6h	272	51	synthesis	synthesis	NN
cord-006788-kz8i4a6h	272	52	and	and	CC
cord-006788-kz8i4a6h	272	53	ileal	ileal	JJ
cord-006788-kz8i4a6h	272	54	malabsorption	malabsorption	NN
cord-006788-kz8i4a6h	272	55	of	of	IN
cord-006788-kz8i4a6h	272	56	bile	bile	NN
cord-006788-kz8i4a6h	272	57	acids	acid	NNS
cord-006788-kz8i4a6h	272	58	in	in	IN
cord-006788-kz8i4a6h	272	59	cynomolgus	cynomolgus	JJ
cord-006788-kz8i4a6h	272	60	monkeys	monkey	NNS
cord-006788-kz8i4a6h	273	1	A	a	DT
cord-006788-kz8i4a6h	273	2	role	role	NN
cord-006788-kz8i4a6h	273	3	for	for	IN
cord-006788-kz8i4a6h	273	4	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	273	5	growth	growth	NN
cord-006788-kz8i4a6h	273	6	factor	factor	NN
cord-006788-kz8i4a6h	273	7	19	19	CD
cord-006788-kz8i4a6h	273	8	and	and	CC
cord-006788-kz8i4a6h	273	9	bile	bile	NN
cord-006788-kz8i4a6h	273	10	acids	acid	NNS
cord-006788-kz8i4a6h	273	11	in	in	IN
cord-006788-kz8i4a6h	273	12	diabetes	diabetes	NN
cord-006788-kz8i4a6h	273	13	remission	remission	NN
cord-006788-kz8i4a6h	273	14	after	after	IN
cord-006788-kz8i4a6h	273	15	Roux	roux	NN
cord-006788-kz8i4a6h	273	16	-	-	HYPH
cord-006788-kz8i4a6h	273	17	en	en	FW
cord-006788-kz8i4a6h	273	18	-	-	HYPH
cord-006788-kz8i4a6h	273	19	Y	Y	NNP
cord-006788-kz8i4a6h	273	20	gastric	gastric	JJ
cord-006788-kz8i4a6h	273	21	bypass	bypass	NN
cord-006788-kz8i4a6h	274	1	A	a	DT
cord-006788-kz8i4a6h	274	2	nontumorigenic	nontumorigenic	JJ
cord-006788-kz8i4a6h	274	3	variant	variant	NN
cord-006788-kz8i4a6h	274	4	of	of	IN
cord-006788-kz8i4a6h	274	5	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	274	6	treats	treat	VBZ
cord-006788-kz8i4a6h	274	7	cholestatic	cholestatic	JJ
cord-006788-kz8i4a6h	274	8	liver	liver	NN
cord-006788-kz8i4a6h	274	9	diseases	disease	NNS
cord-006788-kz8i4a6h	275	1	High	high	JJ
cord-006788-kz8i4a6h	275	2	expression	expression	NN
cord-006788-kz8i4a6h	275	3	of	of	IN
cord-006788-kz8i4a6h	275	4	the	the	DT
cord-006788-kz8i4a6h	275	5	bile	bile	NN
cord-006788-kz8i4a6h	275	6	salt	salt	NN
cord-006788-kz8i4a6h	275	7	-	-	HYPH
cord-006788-kz8i4a6h	275	8	homeostatic	homeostatic	JJ
cord-006788-kz8i4a6h	275	9	hormone	hormone	NN
cord-006788-kz8i4a6h	275	10	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	275	11	growth	growth	NN
cord-006788-kz8i4a6h	275	12	factor	factor	NN
cord-006788-kz8i4a6h	275	13	19	19	CD
cord-006788-kz8i4a6h	275	14	in	in	IN
cord-006788-kz8i4a6h	275	15	the	the	DT
cord-006788-kz8i4a6h	275	16	liver	liver	NN
cord-006788-kz8i4a6h	275	17	of	of	IN
cord-006788-kz8i4a6h	275	18	patients	patient	NNS
cord-006788-kz8i4a6h	275	19	with	with	IN
cord-006788-kz8i4a6h	275	20	extrahepatic	extrahepatic	JJ
cord-006788-kz8i4a6h	275	21	cholestasis	cholestasis	NN
cord-006788-kz8i4a6h	275	22	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	275	23	growth	growth	NN
cord-006788-kz8i4a6h	275	24	factor	factor	NN
cord-006788-kz8i4a6h	275	25	19	19	CD
cord-006788-kz8i4a6h	275	26	regulates	regulate	VBZ
cord-006788-kz8i4a6h	275	27	skeletal	skeletal	JJ
cord-006788-kz8i4a6h	275	28	muscle	muscle	NN
cord-006788-kz8i4a6h	275	29	mass	mass	NN
cord-006788-kz8i4a6h	275	30	and	and	CC
cord-006788-kz8i4a6h	275	31	ameliorates	ameliorate	VBZ
cord-006788-kz8i4a6h	275	32	muscle	muscle	NN
cord-006788-kz8i4a6h	275	33	wasting	waste	VBG
cord-006788-kz8i4a6h	275	34	in	in	IN
cord-006788-kz8i4a6h	275	35	mice	mouse	NNS
cord-006788-kz8i4a6h	276	1	A	a	DT
cord-006788-kz8i4a6h	276	2	mouse	mouse	NN
cord-006788-kz8i4a6h	276	3	model	model	NN
cord-006788-kz8i4a6h	276	4	of	of	IN
cord-006788-kz8i4a6h	276	5	hepatocellular	hepatocellular	JJ
cord-006788-kz8i4a6h	276	6	carcinoma	carcinoma	NN
cord-006788-kz8i4a6h	276	7	:	:	:
cord-006788-kz8i4a6h	276	8	ectopic	ectopic	JJ
cord-006788-kz8i4a6h	276	9	expression	expression	NN
cord-006788-kz8i4a6h	276	10	of	of	IN
cord-006788-kz8i4a6h	276	11	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	276	12	growth	growth	NN
cord-006788-kz8i4a6h	276	13	factor	factor	NN
cord-006788-kz8i4a6h	276	14	19	19	CD
cord-006788-kz8i4a6h	276	15	in	in	IN
cord-006788-kz8i4a6h	276	16	skeletal	skeletal	JJ
cord-006788-kz8i4a6h	276	17	muscle	muscle	NN
cord-006788-kz8i4a6h	276	18	of	of	IN
cord-006788-kz8i4a6h	276	19	transgenic	transgenic	JJ
cord-006788-kz8i4a6h	276	20	mice	mouse	NNS
cord-006788-kz8i4a6h	277	1	Engineered	engineer	VBN
cord-006788-kz8i4a6h	277	2	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	277	3	growth	growth	NN
cord-006788-kz8i4a6h	277	4	factor	factor	NN
cord-006788-kz8i4a6h	277	5	19	19	CD
cord-006788-kz8i4a6h	277	6	reduces	reduce	VBZ
cord-006788-kz8i4a6h	277	7	liver	liver	NN
cord-006788-kz8i4a6h	277	8	injury	injury	NN
cord-006788-kz8i4a6h	277	9	and	and	CC
cord-006788-kz8i4a6h	277	10	resolves	resolve	VBZ
cord-006788-kz8i4a6h	277	11	sclerosing	sclerose	VBG
cord-006788-kz8i4a6h	277	12	cholangitis	cholangitis	NN
cord-006788-kz8i4a6h	277	13	in	in	IN
cord-006788-kz8i4a6h	277	14	Mdr2-deficient	Mdr2-deficient	NNP
cord-006788-kz8i4a6h	277	15	mice	mouse	NNS
cord-006788-kz8i4a6h	278	1	NGM282	NGM282	NNPS
cord-006788-kz8i4a6h	278	2	for	for	IN
cord-006788-kz8i4a6h	278	3	treatment	treatment	NN
cord-006788-kz8i4a6h	278	4	of	of	IN
cord-006788-kz8i4a6h	278	5	patients	patient	NNS
cord-006788-kz8i4a6h	278	6	with	with	IN
cord-006788-kz8i4a6h	278	7	primary	primary	JJ
cord-006788-kz8i4a6h	278	8	biliary	biliary	JJ
cord-006788-kz8i4a6h	278	9	cholangitis	cholangitis	NN
cord-006788-kz8i4a6h	278	10	:	:	:
cord-006788-kz8i4a6h	279	1	a	a	DT
cord-006788-kz8i4a6h	279	2	multicenter	multicenter	NN
cord-006788-kz8i4a6h	279	3	,	,	,
cord-006788-kz8i4a6h	279	4	randomized	randomized	JJ
cord-006788-kz8i4a6h	279	5	,	,	,
cord-006788-kz8i4a6h	279	6	double	double	JJ
cord-006788-kz8i4a6h	279	7	-	-	HYPH
cord-006788-kz8i4a6h	279	8	blind	blind	JJ
cord-006788-kz8i4a6h	279	9	,	,	,
cord-006788-kz8i4a6h	279	10	placebo	placebo	NN
cord-006788-kz8i4a6h	279	11	-	-	HYPH
cord-006788-kz8i4a6h	279	12	controlled	control	VBN
cord-006788-kz8i4a6h	279	13	trial	trial	NN
cord-006788-kz8i4a6h	279	14	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	279	15	growth	growth	NN
cord-006788-kz8i4a6h	279	16	factor	factor	NN
cord-006788-kz8i4a6h	279	17	21	21	CD
cord-006788-kz8i4a6h	279	18	:	:	:
cord-006788-kz8i4a6h	279	19	a	a	DT
cord-006788-kz8i4a6h	279	20	versatile	versatile	JJ
cord-006788-kz8i4a6h	279	21	regulator	regulator	NN
cord-006788-kz8i4a6h	279	22	of	of	IN
cord-006788-kz8i4a6h	279	23	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	279	24	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	279	25	Circulating	circulate	VBG
cord-006788-kz8i4a6h	279	26	levels	level	NNS
cord-006788-kz8i4a6h	279	27	of	of	IN
cord-006788-kz8i4a6h	279	28	FGF-21	FGF-21	NNP
cord-006788-kz8i4a6h	279	29	in	in	IN
cord-006788-kz8i4a6h	279	30	obese	obese	JJ
cord-006788-kz8i4a6h	279	31	youth	youth	NN
cord-006788-kz8i4a6h	279	32	:	:	:
cord-006788-kz8i4a6h	279	33	associations	association	NNS
cord-006788-kz8i4a6h	279	34	with	with	IN
cord-006788-kz8i4a6h	279	35	liver	liver	NN
cord-006788-kz8i4a6h	279	36	fat	fat	NN
cord-006788-kz8i4a6h	279	37	content	content	NN
cord-006788-kz8i4a6h	279	38	and	and	CC
cord-006788-kz8i4a6h	279	39	markers	marker	NNS
cord-006788-kz8i4a6h	279	40	of	of	IN
cord-006788-kz8i4a6h	279	41	liver	liver	NN
cord-006788-kz8i4a6h	279	42	damage	damage	NN
cord-006788-kz8i4a6h	279	43	Dynamic	dynamic	JJ
cord-006788-kz8i4a6h	279	44	change	change	NN
cord-006788-kz8i4a6h	279	45	of	of	IN
cord-006788-kz8i4a6h	279	46	serum	serum	NN
cord-006788-kz8i4a6h	279	47	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	279	48	levels	level	NNS
cord-006788-kz8i4a6h	279	49	in	in	IN
cord-006788-kz8i4a6h	279	50	response	response	NN
cord-006788-kz8i4a6h	279	51	to	to	IN
cord-006788-kz8i4a6h	279	52	glucose	glucose	NN
cord-006788-kz8i4a6h	279	53	challenge	challenge	NN
cord-006788-kz8i4a6h	279	54	in	in	IN
cord-006788-kz8i4a6h	279	55	human	human	JJ
cord-006788-kz8i4a6h	279	56	Increased	Increased	NNP
cord-006788-kz8i4a6h	279	57	serum	serum	NN
cord-006788-kz8i4a6h	279	58	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	279	59	levels	level	NNS
cord-006788-kz8i4a6h	279	60	in	in	IN
cord-006788-kz8i4a6h	279	61	patients	patient	NNS
cord-006788-kz8i4a6h	279	62	with	with	IN
cord-006788-kz8i4a6h	279	63	nonalcoholic	nonalcoholic	JJ
cord-006788-kz8i4a6h	279	64	fatty	fatty	JJ
cord-006788-kz8i4a6h	279	65	liver	liver	NN
cord-006788-kz8i4a6h	279	66	disease	disease	NN
cord-006788-kz8i4a6h	280	1	A	a	DT
cord-006788-kz8i4a6h	280	2	dozen	dozen	NN
cord-006788-kz8i4a6h	280	3	years	year	NNS
cord-006788-kz8i4a6h	280	4	of	of	IN
cord-006788-kz8i4a6h	280	5	discovery	discovery	NN
cord-006788-kz8i4a6h	280	6	:	:	:
cord-006788-kz8i4a6h	281	1	insights	insight	NNS
cord-006788-kz8i4a6h	281	2	into	into	IN
cord-006788-kz8i4a6h	281	3	the	the	DT
cord-006788-kz8i4a6h	281	4	physiology	physiology	NN
cord-006788-kz8i4a6h	281	5	and	and	CC
cord-006788-kz8i4a6h	281	6	pharmacology	pharmacology	NN
cord-006788-kz8i4a6h	281	7	of	of	IN
cord-006788-kz8i4a6h	281	8	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	281	9	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	281	10	is	be	VBZ
cord-006788-kz8i4a6h	281	11	an	an	DT
cord-006788-kz8i4a6h	281	12	endocrine	endocrine	JJ
cord-006788-kz8i4a6h	281	13	signal	signal	NN
cord-006788-kz8i4a6h	281	14	of	of	IN
cord-006788-kz8i4a6h	281	15	protein	protein	NN
cord-006788-kz8i4a6h	281	16	restriction	restriction	NN
cord-006788-kz8i4a6h	282	1	A	a	DT
cord-006788-kz8i4a6h	282	2	critical	critical	JJ
cord-006788-kz8i4a6h	282	3	role	role	NN
cord-006788-kz8i4a6h	282	4	for	for	IN
cord-006788-kz8i4a6h	282	5	ChREBP	chrebp	NN
cord-006788-kz8i4a6h	282	6	-	-	HYPH
cord-006788-kz8i4a6h	282	7	mediated	mediate	VBN
cord-006788-kz8i4a6h	282	8	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	282	9	secretion	secretion	NN
cord-006788-kz8i4a6h	282	10	in	in	IN
cord-006788-kz8i4a6h	283	1	hepatic	hepatic	JJ
cord-006788-kz8i4a6h	283	2	fructose	fructose	NN
cord-006788-kz8i4a6h	283	3	metabolism	metabolism	NN
cord-006788-kz8i4a6h	283	4	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	283	5	mediates	mediate	VBZ
cord-006788-kz8i4a6h	283	6	endocrine	endocrine	JJ
cord-006788-kz8i4a6h	283	7	control	control	NN
cord-006788-kz8i4a6h	283	8	of	of	IN
cord-006788-kz8i4a6h	283	9	simple	simple	JJ
cord-006788-kz8i4a6h	283	10	sugar	sugar	NN
cord-006788-kz8i4a6h	283	11	intake	intake	NN
cord-006788-kz8i4a6h	283	12	and	and	CC
cord-006788-kz8i4a6h	283	13	sweet	sweet	JJ
cord-006788-kz8i4a6h	283	14	taste	taste	NN
cord-006788-kz8i4a6h	283	15	preference	preference	NN
cord-006788-kz8i4a6h	283	16	by	by	IN
cord-006788-kz8i4a6h	283	17	the	the	DT
cord-006788-kz8i4a6h	283	18	liver	liver	NN
cord-006788-kz8i4a6h	284	1	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	284	2	regulates	regulate	VBZ
cord-006788-kz8i4a6h	284	3	sweet	sweet	JJ
cord-006788-kz8i4a6h	284	4	and	and	CC
cord-006788-kz8i4a6h	284	5	alcohol	alcohol	NN
cord-006788-kz8i4a6h	284	6	preference	preference	NN
cord-006788-kz8i4a6h	284	7	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	284	8	growth	growth	NN
cord-006788-kz8i4a6h	284	9	factor	factor	NN
cord-006788-kz8i4a6h	284	10	21	21	CD
cord-006788-kz8i4a6h	284	11	limits	limit	NNS
cord-006788-kz8i4a6h	284	12	lipotoxicity	lipotoxicity	NN
cord-006788-kz8i4a6h	284	13	by	by	IN
cord-006788-kz8i4a6h	284	14	promoting	promote	VBG
cord-006788-kz8i4a6h	284	15	hepatic	hepatic	JJ
cord-006788-kz8i4a6h	284	16	fatty	fatty	JJ
cord-006788-kz8i4a6h	284	17	acid	acid	NN
cord-006788-kz8i4a6h	284	18	activation	activation	NN
cord-006788-kz8i4a6h	284	19	in	in	IN
cord-006788-kz8i4a6h	284	20	mice	mouse	NNS
cord-006788-kz8i4a6h	284	21	on	on	IN
cord-006788-kz8i4a6h	284	22	methionine	methionine	NN
cord-006788-kz8i4a6h	284	23	and	and	CC
cord-006788-kz8i4a6h	284	24	cholinedeficient	cholinedeficient	NN
cord-006788-kz8i4a6h	284	25	diets	diet	NNS
cord-006788-kz8i4a6h	284	26	Forced	force	VBD
cord-006788-kz8i4a6h	284	27	expression	expression	NN
cord-006788-kz8i4a6h	284	28	of	of	IN
cord-006788-kz8i4a6h	284	29	hepatocyte	hepatocyte	NN
cord-006788-kz8i4a6h	284	30	-	-	HYPH
cord-006788-kz8i4a6h	284	31	specific	specific	JJ
cord-006788-kz8i4a6h	284	32	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	284	33	growth	growth	NN
cord-006788-kz8i4a6h	284	34	factor	factor	NN
cord-006788-kz8i4a6h	284	35	21	21	CD
cord-006788-kz8i4a6h	284	36	delays	delay	NNS
cord-006788-kz8i4a6h	284	37	initiation	initiation	NN
cord-006788-kz8i4a6h	284	38	of	of	IN
cord-006788-kz8i4a6h	284	39	chemically	chemically	RB
cord-006788-kz8i4a6h	284	40	induced	induce	VBN
cord-006788-kz8i4a6h	284	41	hepatocarcinogenesis	hepatocarcinogenesis	NN
cord-006788-kz8i4a6h	284	42	Role	role	NN
cord-006788-kz8i4a6h	284	43	of	of	IN
cord-006788-kz8i4a6h	284	44	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	284	45	growth	growth	NN
cord-006788-kz8i4a6h	284	46	factor	factor	NN
cord-006788-kz8i4a6h	284	47	21	21	CD
cord-006788-kz8i4a6h	284	48	in	in	IN
cord-006788-kz8i4a6h	284	49	the	the	DT
cord-006788-kz8i4a6h	284	50	early	early	JJ
cord-006788-kz8i4a6h	284	51	stage	stage	NN
cord-006788-kz8i4a6h	284	52	of	of	IN
cord-006788-kz8i4a6h	284	53	NASH	NASH	NNP
cord-006788-kz8i4a6h	284	54	induced	induce	VBN
cord-006788-kz8i4a6h	284	55	by	by	IN
cord-006788-kz8i4a6h	284	56	methionine	methionine	NN
cord-006788-kz8i4a6h	284	57	-	-	HYPH
cord-006788-kz8i4a6h	284	58	and	and	CC
cord-006788-kz8i4a6h	284	59	choline	choline	NN
cord-006788-kz8i4a6h	284	60	-	-	HYPH
cord-006788-kz8i4a6h	284	61	deficient	deficient	JJ
cord-006788-kz8i4a6h	284	62	diet	diet	NN
cord-006788-kz8i4a6h	284	63	Maratos	Maratos	NNP
cord-006788-kz8i4a6h	284	64	-	-	HYPH
cord-006788-kz8i4a6h	284	65	Flier	Flier	NNP
cord-006788-kz8i4a6h	284	66	E.	E.	NNP
cord-006788-kz8i4a6h	284	67	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	284	68	growth	growth	NN
cord-006788-kz8i4a6h	284	69	factor	factor	NN
cord-006788-kz8i4a6h	284	70	21	21	CD
cord-006788-kz8i4a6h	285	1	(	(	-LRB-
cord-006788-kz8i4a6h	285	2	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	285	3	)	)	-RRB-
cord-006788-kz8i4a6h	285	4	is	be	VBZ
cord-006788-kz8i4a6h	285	5	robustly	robustly	RB
cord-006788-kz8i4a6h	285	6	induced	induce	VBN
cord-006788-kz8i4a6h	285	7	by	by	IN
cord-006788-kz8i4a6h	285	8	ethanol	ethanol	NN
cord-006788-kz8i4a6h	285	9	and	and	CC
cord-006788-kz8i4a6h	285	10	has	have	VBZ
cord-006788-kz8i4a6h	285	11	a	a	DT
cord-006788-kz8i4a6h	285	12	protective	protective	JJ
cord-006788-kz8i4a6h	285	13	role	role	NN
cord-006788-kz8i4a6h	285	14	in	in	IN
cord-006788-kz8i4a6h	285	15	ethanol	ethanol	NN
cord-006788-kz8i4a6h	285	16	associated	associate	VBD
cord-006788-kz8i4a6h	285	17	liver	liver	NN
cord-006788-kz8i4a6h	285	18	injury	injury	NN
cord-006788-kz8i4a6h	285	19	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	285	20	growth	growth	NN
cord-006788-kz8i4a6h	285	21	factor	factor	NN
cord-006788-kz8i4a6h	285	22	21	21	CD
cord-006788-kz8i4a6h	285	23	protects	protect	NNS
cord-006788-kz8i4a6h	285	24	against	against	IN
cord-006788-kz8i4a6h	285	25	acetaminopheninduced	acetaminopheninduce	VBN
cord-006788-kz8i4a6h	285	26	hepatotoxicity	hepatotoxicity	NN
cord-006788-kz8i4a6h	285	27	by	by	IN
cord-006788-kz8i4a6h	285	28	potentiating	potentiate	VBG
cord-006788-kz8i4a6h	285	29	peroxisome	peroxisome	NN
cord-006788-kz8i4a6h	285	30	proliferatoractivated	proliferatoractivated	JJ
cord-006788-kz8i4a6h	285	31	receptor	receptor	NN
cord-006788-kz8i4a6h	285	32	coactivator	coactivator	NN
cord-006788-kz8i4a6h	285	33	protein-1α	protein-1α	NNP
cord-006788-kz8i4a6h	285	34	-	-	HYPH
cord-006788-kz8i4a6h	285	35	mediated	mediate	VBN
cord-006788-kz8i4a6h	285	36	antioxidant	antioxidant	JJ
cord-006788-kz8i4a6h	285	37	capacity	capacity	NN
cord-006788-kz8i4a6h	285	38	in	in	IN
cord-006788-kz8i4a6h	285	39	mice	mouse	NNS
cord-006788-kz8i4a6h	285	40	Maratos	Maratos	NNP
cord-006788-kz8i4a6h	285	41	-	-	HYPH
cord-006788-kz8i4a6h	285	42	Flier	Flier	NNP
cord-006788-kz8i4a6h	285	43	E.	E.	NNP
cord-006788-kz8i4a6h	285	44	Deficiency	deficiency	NN
cord-006788-kz8i4a6h	285	45	of	of	IN
cord-006788-kz8i4a6h	285	46	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	285	47	growth	growth	NN
cord-006788-kz8i4a6h	285	48	factor	factor	NN
cord-006788-kz8i4a6h	285	49	21	21	CD
cord-006788-kz8i4a6h	285	50	(	(	-LRB-
cord-006788-kz8i4a6h	285	51	FGF21	fgf21	NN
cord-006788-kz8i4a6h	285	52	)	)	-RRB-
cord-006788-kz8i4a6h	285	53	promotes	promote	VBZ
cord-006788-kz8i4a6h	285	54	hepatocellular	hepatocellular	JJ
cord-006788-kz8i4a6h	285	55	carcinoma	carcinoma	NN
cord-006788-kz8i4a6h	285	56	(	(	-LRB-
cord-006788-kz8i4a6h	285	57	HCC	HCC	NNP
cord-006788-kz8i4a6h	285	58	)	)	-RRB-
cord-006788-kz8i4a6h	285	59	in	in	IN
cord-006788-kz8i4a6h	285	60	mice	mouse	NNS
cord-006788-kz8i4a6h	285	61	on	on	IN
cord-006788-kz8i4a6h	285	62	a	a	DT
cord-006788-kz8i4a6h	285	63	long	long	JJ
cord-006788-kz8i4a6h	285	64	term	term	NN
cord-006788-kz8i4a6h	285	65	obesogenic	obesogenic	NN
cord-006788-kz8i4a6h	285	66	diet	diet	NN
cord-006788-kz8i4a6h	285	67	FGF21-FGFR1	FGF21-FGFR1	NNP
cord-006788-kz8i4a6h	285	68	coordinates	coordinate	VBZ
cord-006788-kz8i4a6h	285	69	phospholipid	phospholipid	NN
cord-006788-kz8i4a6h	285	70	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	285	71	,	,	,
cord-006788-kz8i4a6h	285	72	lipid	lipid	NN
cord-006788-kz8i4a6h	285	73	droplet	droplet	NN
cord-006788-kz8i4a6h	285	74	function	function	NN
cord-006788-kz8i4a6h	285	75	,	,	,
cord-006788-kz8i4a6h	285	76	and	and	CC
cord-006788-kz8i4a6h	285	77	ER	ER	NNP
cord-006788-kz8i4a6h	285	78	stress	stress	NN
cord-006788-kz8i4a6h	285	79	in	in	IN
cord-006788-kz8i4a6h	285	80	obesity	obesity	NN
cord-006788-kz8i4a6h	285	81	Treating	treat	VBG
cord-006788-kz8i4a6h	285	82	diabetes	diabetes	NN
cord-006788-kz8i4a6h	285	83	and	and	CC
cord-006788-kz8i4a6h	285	84	obesity	obesity	NN
cord-006788-kz8i4a6h	285	85	with	with	IN
cord-006788-kz8i4a6h	285	86	an	an	DT
cord-006788-kz8i4a6h	285	87	FGF21-mimetic	fgf21-mimetic	JJ
cord-006788-kz8i4a6h	285	88	antibody	antibody	NN
cord-006788-kz8i4a6h	285	89	activating	activate	VBG
cord-006788-kz8i4a6h	285	90	the	the	DT
cord-006788-kz8i4a6h	285	91	βKlotho	βKlotho	NNP
cord-006788-kz8i4a6h	285	92	/	/	SYM
cord-006788-kz8i4a6h	285	93	FGFR1c	FGFR1c	NNP
cord-006788-kz8i4a6h	285	94	receptor	receptor	NN
cord-006788-kz8i4a6h	285	95	complex	complex	NN
cord-006788-kz8i4a6h	286	1	The	the	DT
cord-006788-kz8i4a6h	286	2	effects	effect	NNS
cord-006788-kz8i4a6h	286	3	of	of	IN
cord-006788-kz8i4a6h	286	4	LY2405319	LY2405319	NNP
cord-006788-kz8i4a6h	286	5	,	,	,
cord-006788-kz8i4a6h	286	6	an	an	DT
cord-006788-kz8i4a6h	286	7	FGF21	fgf21	NN
cord-006788-kz8i4a6h	286	8	analog	analog	NN
cord-006788-kz8i4a6h	286	9	,	,	,
cord-006788-kz8i4a6h	286	10	in	in	IN
cord-006788-kz8i4a6h	286	11	obese	obese	JJ
cord-006788-kz8i4a6h	286	12	human	human	JJ
cord-006788-kz8i4a6h	286	13	subjects	subject	NNS
cord-006788-kz8i4a6h	286	14	with	with	IN
cord-006788-kz8i4a6h	286	15	type	type	NN
cord-006788-kz8i4a6h	286	16	2	2	CD
cord-006788-kz8i4a6h	286	17	diabetes	diabetes	NN
cord-006788-kz8i4a6h	287	1	Adiponectin	Adiponectin	NNP
cord-006788-kz8i4a6h	287	2	mediates	mediate	VBZ
cord-006788-kz8i4a6h	287	3	the	the	DT
cord-006788-kz8i4a6h	287	4	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	287	5	effects	effect	NNS
cord-006788-kz8i4a6h	287	6	of	of	IN
cord-006788-kz8i4a6h	287	7	FGF21	fgf21	NN
cord-006788-kz8i4a6h	287	8	on	on	IN
cord-006788-kz8i4a6h	287	9	glucose	glucose	NN
cord-006788-kz8i4a6h	287	10	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	287	11	and	and	CC
cord-006788-kz8i4a6h	287	12	insulin	insulin	NN
cord-006788-kz8i4a6h	287	13	sensitivity	sensitivity	NN
cord-006788-kz8i4a6h	287	14	in	in	IN
cord-006788-kz8i4a6h	287	15	mice	mouse	NNS
cord-006788-kz8i4a6h	288	1	The	the	DT
cord-006788-kz8i4a6h	288	2	FGF21-CCL11	FGF21-CCL11	NNP
cord-006788-kz8i4a6h	288	3	axis	axis	NN
cord-006788-kz8i4a6h	288	4	mediates	mediate	VBZ
cord-006788-kz8i4a6h	288	5	beiging	beige	VBG
cord-006788-kz8i4a6h	288	6	of	of	IN
cord-006788-kz8i4a6h	288	7	white	white	JJ
cord-006788-kz8i4a6h	288	8	adipose	adipose	JJ
cord-006788-kz8i4a6h	288	9	tissues	tissue	NNS
cord-006788-kz8i4a6h	288	10	by	by	IN
cord-006788-kz8i4a6h	288	11	coupling	couple	VBG
cord-006788-kz8i4a6h	288	12	sympathetic	sympathetic	JJ
cord-006788-kz8i4a6h	288	13	nervous	nervous	JJ
cord-006788-kz8i4a6h	288	14	system	system	NN
cord-006788-kz8i4a6h	288	15	to	to	TO
cord-006788-kz8i4a6h	288	16	type	type	VB
cord-006788-kz8i4a6h	288	17	2	2	CD
cord-006788-kz8i4a6h	288	18	immunity	immunity	NN
cord-006788-kz8i4a6h	288	19	Irisin	Irisin	NNP
cord-006788-kz8i4a6h	288	20	and	and	CC
cord-006788-kz8i4a6h	288	21	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	289	1	are	be	VBP
cord-006788-kz8i4a6h	289	2	cold	cold	JJ
cord-006788-kz8i4a6h	289	3	-	-	HYPH
cord-006788-kz8i4a6h	289	4	induced	induce	VBN
cord-006788-kz8i4a6h	289	5	endocrine	endocrine	JJ
cord-006788-kz8i4a6h	289	6	activators	activator	NNS
cord-006788-kz8i4a6h	289	7	of	of	IN
cord-006788-kz8i4a6h	289	8	brown	brown	JJ
cord-006788-kz8i4a6h	289	9	fat	fat	JJ
cord-006788-kz8i4a6h	289	10	function	function	NN
cord-006788-kz8i4a6h	289	11	in	in	IN
cord-006788-kz8i4a6h	289	12	humans	human	NNS
cord-006788-kz8i4a6h	289	13	Thermogenic	Thermogenic	NNP
cord-006788-kz8i4a6h	289	14	activation	activation	NN
cord-006788-kz8i4a6h	289	15	induces	induce	VBZ
cord-006788-kz8i4a6h	289	16	FGF21	fgf21	JJ
cord-006788-kz8i4a6h	289	17	expression	expression	NN
cord-006788-kz8i4a6h	289	18	and	and	CC
cord-006788-kz8i4a6h	289	19	release	release	NN
cord-006788-kz8i4a6h	289	20	in	in	IN
cord-006788-kz8i4a6h	290	1	brown	brown	JJ
cord-006788-kz8i4a6h	290	2	adipose	adipose	JJ
cord-006788-kz8i4a6h	290	3	tissue	tissue	NN
cord-006788-kz8i4a6h	290	4	Liver	liver	NN
cord-006788-kz8i4a6h	290	5	derived	derive	VBN
cord-006788-kz8i4a6h	291	1	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	291	2	maintains	maintain	VBZ
cord-006788-kz8i4a6h	291	3	core	core	NN
cord-006788-kz8i4a6h	291	4	body	body	NN
cord-006788-kz8i4a6h	291	5	temperature	temperature	NN
cord-006788-kz8i4a6h	291	6	during	during	IN
cord-006788-kz8i4a6h	291	7	acute	acute	JJ
cord-006788-kz8i4a6h	291	8	cold	cold	JJ
cord-006788-kz8i4a6h	291	9	exposure	exposure	NN
cord-006788-kz8i4a6h	291	10	The	the	DT
cord-006788-kz8i4a6h	291	11	starvation	starvation	NN
cord-006788-kz8i4a6h	291	12	hormone	hormone	NN
cord-006788-kz8i4a6h	291	13	,	,	,
cord-006788-kz8i4a6h	291	14	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	291	15	growth	growth	NN
cord-006788-kz8i4a6h	291	16	factor-21	factor-21	NNP
cord-006788-kz8i4a6h	291	17	,	,	,
cord-006788-kz8i4a6h	291	18	extends	extend	VBZ
cord-006788-kz8i4a6h	291	19	lifespan	lifespan	NN
cord-006788-kz8i4a6h	291	20	in	in	IN
cord-006788-kz8i4a6h	291	21	mice	mouse	NNS
cord-006788-kz8i4a6h	292	1	Prolongevity	prolongevity	NN
cord-006788-kz8i4a6h	292	2	hormone	hormone	NN
cord-006788-kz8i4a6h	292	3	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	292	4	protects	protect	VBZ
cord-006788-kz8i4a6h	292	5	against	against	IN
cord-006788-kz8i4a6h	292	6	immune	immune	JJ
cord-006788-kz8i4a6h	292	7	senescence	senescence	NN
cord-006788-kz8i4a6h	292	8	by	by	IN
cord-006788-kz8i4a6h	292	9	delaying	delay	VBG
cord-006788-kz8i4a6h	292	10	age	age	NN
cord-006788-kz8i4a6h	292	11	-	-	HYPH
cord-006788-kz8i4a6h	292	12	related	relate	VBN
cord-006788-kz8i4a6h	292	13	thymic	thymic	JJ
cord-006788-kz8i4a6h	292	14	involution	involution	NN
cord-006788-kz8i4a6h	292	15	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	292	16	growth	growth	NN
cord-006788-kz8i4a6h	292	17	factor	factor	NN
cord-006788-kz8i4a6h	292	18	21	21	CD
cord-006788-kz8i4a6h	293	1	is	be	VBZ
cord-006788-kz8i4a6h	293	2	not	not	RB
cord-006788-kz8i4a6h	293	3	required	require	VBN
cord-006788-kz8i4a6h	293	4	for	for	IN
cord-006788-kz8i4a6h	293	5	the	the	DT
cord-006788-kz8i4a6h	293	6	antidiabetic	antidiabetic	JJ
cord-006788-kz8i4a6h	293	7	actions	action	NNS
cord-006788-kz8i4a6h	293	8	of	of	IN
cord-006788-kz8i4a6h	293	9	the	the	DT
cord-006788-kz8i4a6h	293	10	thiazoladinediones	thiazoladinedione	NNS
cord-006788-kz8i4a6h	294	1	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	294	2	is	be	VBZ
cord-006788-kz8i4a6h	295	1	an	an	DT
cord-006788-kz8i4a6h	295	2	exocrine	exocrine	JJ
cord-006788-kz8i4a6h	295	3	pancreas	pancreas	NN
cord-006788-kz8i4a6h	295	4	secretagogue	secretagogue	NN
cord-006788-kz8i4a6h	295	5	Maratos	Maratos	NNP
cord-006788-kz8i4a6h	295	6	-	-	HYPH
cord-006788-kz8i4a6h	295	7	Flier	Flier	NNP
cord-006788-kz8i4a6h	295	8	E.	E.	NNP
cord-006788-kz8i4a6h	295	9	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	295	10	growth	growth	NN
cord-006788-kz8i4a6h	295	11	factor	factor	NN
cord-006788-kz8i4a6h	295	12	21	21	CD
cord-006788-kz8i4a6h	295	13	(	(	-LRB-
cord-006788-kz8i4a6h	295	14	FGF21	fgf21	NN
cord-006788-kz8i4a6h	295	15	)	)	-RRB-
cord-006788-kz8i4a6h	295	16	protects	protect	VBZ
cord-006788-kz8i4a6h	295	17	against	against	IN
cord-006788-kz8i4a6h	295	18	high	high	JJ
cord-006788-kz8i4a6h	295	19	fat	fat	JJ
cord-006788-kz8i4a6h	295	20	diet	diet	NN
cord-006788-kz8i4a6h	295	21	induced	induce	VBN
cord-006788-kz8i4a6h	295	22	inflammation	inflammation	NN
cord-006788-kz8i4a6h	295	23	and	and	CC
cord-006788-kz8i4a6h	295	24	islet	islet	NN
cord-006788-kz8i4a6h	295	25	hyperplasia	hyperplasia	NN
cord-006788-kz8i4a6h	295	26	in	in	IN
cord-006788-kz8i4a6h	295	27	pancreas	pancreas	NN
cord-006788-kz8i4a6h	295	28	Silencing	silencing	NN
cord-006788-kz8i4a6h	295	29	of	of	IN
cord-006788-kz8i4a6h	295	30	the	the	DT
cord-006788-kz8i4a6h	295	31	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	295	32	growth	growth	NN
cord-006788-kz8i4a6h	295	33	factor	factor	NN
cord-006788-kz8i4a6h	295	34	21	21	CD
cord-006788-kz8i4a6h	295	35	gene	gene	NN
cord-006788-kz8i4a6h	295	36	is	be	VBZ
cord-006788-kz8i4a6h	295	37	an	an	DT
cord-006788-kz8i4a6h	295	38	underlying	underlying	JJ
cord-006788-kz8i4a6h	295	39	cause	cause	NN
cord-006788-kz8i4a6h	295	40	of	of	IN
cord-006788-kz8i4a6h	295	41	acinar	acinar	JJ
cord-006788-kz8i4a6h	295	42	cell	cell	NN
cord-006788-kz8i4a6h	295	43	injury	injury	NN
cord-006788-kz8i4a6h	295	44	in	in	IN
cord-006788-kz8i4a6h	295	45	mice	mouse	NNS
cord-006788-kz8i4a6h	296	1	lacking	lack	VBG
cord-006788-kz8i4a6h	296	2	MIST1	MIST1	NNP
cord-006788-kz8i4a6h	297	1	Fibroblast	fibroblast	JJ
cord-006788-kz8i4a6h	297	2	growth	growth	NN
cord-006788-kz8i4a6h	297	3	factor	factor	NN
cord-006788-kz8i4a6h	297	4	21	21	CD
cord-006788-kz8i4a6h	297	5	reduces	reduce	VBZ
cord-006788-kz8i4a6h	297	6	the	the	DT
cord-006788-kz8i4a6h	297	7	severity	severity	NN
cord-006788-kz8i4a6h	297	8	of	of	IN
cord-006788-kz8i4a6h	297	9	cerulein	cerulein	NN
cord-006788-kz8i4a6h	297	10	-	-	HYPH
cord-006788-kz8i4a6h	297	11	induced	induce	VBN
cord-006788-kz8i4a6h	297	12	pancreatitis	pancreatitis	NN
cord-006788-kz8i4a6h	297	13	in	in	IN
cord-006788-kz8i4a6h	297	14	mice	mouse	NNS
cord-006788-kz8i4a6h	298	1	Peripherally	peripherally	RB
cord-006788-kz8i4a6h	298	2	derived	derive	VBN
cord-006788-kz8i4a6h	298	3	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	298	4	promotes	promote	VBZ
cord-006788-kz8i4a6h	298	5	remyelination	remyelination	NN
cord-006788-kz8i4a6h	298	6	in	in	IN
cord-006788-kz8i4a6h	298	7	the	the	DT
cord-006788-kz8i4a6h	298	8	central	central	JJ
cord-006788-kz8i4a6h	298	9	nervous	nervous	JJ
cord-006788-kz8i4a6h	298	10	system	system	NN
cord-006788-kz8i4a6h	299	1	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	299	2	is	be	VBZ
cord-006788-kz8i4a6h	299	3	a	a	DT
cord-006788-kz8i4a6h	299	4	sugar	sugar	NN
cord-006788-kz8i4a6h	299	5	-	-	HYPH
cord-006788-kz8i4a6h	299	6	induced	induce	VBN
cord-006788-kz8i4a6h	299	7	hormone	hormone	NN
cord-006788-kz8i4a6h	299	8	associated	associate	VBN
cord-006788-kz8i4a6h	299	9	with	with	IN
cord-006788-kz8i4a6h	299	10	sweet	sweet	JJ
cord-006788-kz8i4a6h	299	11	intake	intake	NN
cord-006788-kz8i4a6h	299	12	and	and	CC
cord-006788-kz8i4a6h	299	13	preference	preference	NN
cord-006788-kz8i4a6h	299	14	in	in	IN
cord-006788-kz8i4a6h	299	15	humans	human	NNS
cord-006788-kz8i4a6h	300	1	The	the	DT
cord-006788-kz8i4a6h	300	2	hormone	hormone	NN
cord-006788-kz8i4a6h	300	3	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	300	4	stimulates	stimulate	VBZ
cord-006788-kz8i4a6h	300	5	water	water	NN
cord-006788-kz8i4a6h	300	6	drinking	drink	VBG
cord-006788-kz8i4a6h	300	7	in	in	IN
cord-006788-kz8i4a6h	300	8	response	response	NN
cord-006788-kz8i4a6h	300	9	to	to	IN
cord-006788-kz8i4a6h	300	10	ketogenic	ketogenic	JJ
cord-006788-kz8i4a6h	300	11	diet	diet	NN
cord-006788-kz8i4a6h	300	12	and	and	CC
cord-006788-kz8i4a6h	300	13	alcohol	alcohol	NN
cord-006788-kz8i4a6h	301	1	A	a	DT
cord-006788-kz8i4a6h	301	2	common	common	JJ
cord-006788-kz8i4a6h	301	3	allele	allele	NN
cord-006788-kz8i4a6h	301	4	in	in	IN
cord-006788-kz8i4a6h	301	5	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	301	6	associated	associate	VBN
cord-006788-kz8i4a6h	301	7	with	with	IN
cord-006788-kz8i4a6h	301	8	sugar	sugar	NN
cord-006788-kz8i4a6h	301	9	intake	intake	NN
cord-006788-kz8i4a6h	301	10	is	be	VBZ
cord-006788-kz8i4a6h	301	11	associated	associate	VBN
cord-006788-kz8i4a6h	301	12	with	with	IN
cord-006788-kz8i4a6h	301	13	body	body	NN
cord-006788-kz8i4a6h	301	14	shape	shape	NN
cord-006788-kz8i4a6h	301	15	,	,	,
cord-006788-kz8i4a6h	301	16	lower	low	JJR
cord-006788-kz8i4a6h	301	17	total	total	JJ
cord-006788-kz8i4a6h	301	18	body	body	NN
cord-006788-kz8i4a6h	301	19	-	-	HYPH
cord-006788-kz8i4a6h	301	20	fat	fat	NN
cord-006788-kz8i4a6h	301	21	percentage	percentage	NN
cord-006788-kz8i4a6h	301	22	,	,	,
cord-006788-kz8i4a6h	301	23	and	and	CC
cord-006788-kz8i4a6h	301	24	higher	high	JJR
cord-006788-kz8i4a6h	301	25	blood	blood	NN
cord-006788-kz8i4a6h	301	26	pressure	pressure	NN
cord-006788-kz8i4a6h	301	27	Neuronal	neuronal	JJ
cord-006788-kz8i4a6h	301	28	mitochondrial	mitochondrial	JJ
cord-006788-kz8i4a6h	301	29	dysfunction	dysfunction	NN
cord-006788-kz8i4a6h	301	30	activates	activate	VBZ
cord-006788-kz8i4a6h	301	31	the	the	DT
cord-006788-kz8i4a6h	301	32	integrated	integrated	JJ
cord-006788-kz8i4a6h	301	33	stress	stress	NN
cord-006788-kz8i4a6h	301	34	response	response	NN
cord-006788-kz8i4a6h	301	35	to	to	TO
cord-006788-kz8i4a6h	301	36	induce	induce	VB
cord-006788-kz8i4a6h	301	37	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	301	38	growth	growth	NN
cord-006788-kz8i4a6h	301	39	factor	factor	NN
cord-006788-kz8i4a6h	301	40	21	21	CD
cord-006788-kz8i4a6h	301	41	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	301	42	growth	growth	NN
cord-006788-kz8i4a6h	301	43	factor	factor	NN
cord-006788-kz8i4a6h	301	44	21	21	CD
cord-006788-kz8i4a6h	301	45	protects	protect	NNS
cord-006788-kz8i4a6h	301	46	against	against	IN
cord-006788-kz8i4a6h	301	47	cardiac	cardiac	JJ
cord-006788-kz8i4a6h	301	48	hypertrophy	hypertrophy	NN
cord-006788-kz8i4a6h	301	49	in	in	IN
cord-006788-kz8i4a6h	301	50	mice	mouse	NNS
cord-006788-kz8i4a6h	302	1	Divergent	divergent	JJ
cord-006788-kz8i4a6h	302	2	effects	effect	NNS
cord-006788-kz8i4a6h	302	3	of	of	IN
cord-006788-kz8i4a6h	302	4	resistance	resistance	NN
cord-006788-kz8i4a6h	302	5	and	and	CC
cord-006788-kz8i4a6h	302	6	endurance	endurance	NN
cord-006788-kz8i4a6h	302	7	exercise	exercise	NN
cord-006788-kz8i4a6h	302	8	on	on	IN
cord-006788-kz8i4a6h	302	9	plasma	plasma	NN
cord-006788-kz8i4a6h	302	10	bile	bile	NN
cord-006788-kz8i4a6h	302	11	acids	acid	NNS
cord-006788-kz8i4a6h	302	12	,	,	,
cord-006788-kz8i4a6h	302	13	FGF19	FGF19	NNP
cord-006788-kz8i4a6h	302	14	,	,	,
cord-006788-kz8i4a6h	302	15	and	and	CC
cord-006788-kz8i4a6h	302	16	FGF21	fgf21	NN
cord-006788-kz8i4a6h	302	17	in	in	IN
cord-006788-kz8i4a6h	303	1	humans	human	NNS
cord-006788-kz8i4a6h	303	2	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	303	3	growth	growth	NN
cord-006788-kz8i4a6h	303	4	factor	factor	NN
cord-006788-kz8i4a6h	303	5	21	21	CD
cord-006788-kz8i4a6h	303	6	is	be	VBZ
cord-006788-kz8i4a6h	303	7	induced	induce	VBN
cord-006788-kz8i4a6h	303	8	upon	upon	IN
cord-006788-kz8i4a6h	303	9	cardiac	cardiac	JJ
cord-006788-kz8i4a6h	303	10	stress	stress	NN
cord-006788-kz8i4a6h	303	11	and	and	CC
cord-006788-kz8i4a6h	303	12	alters	alter	VBZ
cord-006788-kz8i4a6h	303	13	cardiac	cardiac	JJ
cord-006788-kz8i4a6h	303	14	lipid	lipid	NN
cord-006788-kz8i4a6h	303	15	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	303	16	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	303	17	growth	growth	NN
cord-006788-kz8i4a6h	303	18	factor	factor	NN
cord-006788-kz8i4a6h	303	19	21	21	CD
cord-006788-kz8i4a6h	303	20	prevents	prevent	VBZ
cord-006788-kz8i4a6h	303	21	atherosclerosis	atherosclerosis	NN
cord-006788-kz8i4a6h	303	22	by	by	IN
cord-006788-kz8i4a6h	303	23	suppression	suppression	NN
cord-006788-kz8i4a6h	303	24	of	of	IN
cord-006788-kz8i4a6h	303	25	hepatic	hepatic	JJ
cord-006788-kz8i4a6h	303	26	sterol	sterol	NN
cord-006788-kz8i4a6h	303	27	regulatory	regulatory	JJ
cord-006788-kz8i4a6h	303	28	element	element	NN
cord-006788-kz8i4a6h	303	29	-	-	HYPH
cord-006788-kz8i4a6h	303	30	binding	bind	VBG
cord-006788-kz8i4a6h	303	31	protein-2	protein-2	NNS
cord-006788-kz8i4a6h	303	32	and	and	CC
cord-006788-kz8i4a6h	303	33	induction	induction	NN
cord-006788-kz8i4a6h	303	34	of	of	IN
cord-006788-kz8i4a6h	303	35	adiponectin	adiponectin	NN
cord-006788-kz8i4a6h	303	36	in	in	IN
cord-006788-kz8i4a6h	303	37	mice	mouse	NNS
cord-006788-kz8i4a6h	303	38	Endocrine	endocrine	JJ
cord-006788-kz8i4a6h	303	39	protection	protection	NN
cord-006788-kz8i4a6h	303	40	of	of	IN
cord-006788-kz8i4a6h	303	41	ischemic	ischemic	JJ
cord-006788-kz8i4a6h	303	42	myocardium	myocardium	NN
cord-006788-kz8i4a6h	303	43	by	by	IN
cord-006788-kz8i4a6h	303	44	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	303	45	from	from	IN
cord-006788-kz8i4a6h	303	46	the	the	DT
cord-006788-kz8i4a6h	303	47	liver	liver	NN
cord-006788-kz8i4a6h	303	48	and	and	CC
cord-006788-kz8i4a6h	303	49	adipose	adipose	NN
cord-006788-kz8i4a6h	303	50	tissue	tissue	NN
cord-006788-kz8i4a6h	303	51	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	303	52	growth	growth	NN
cord-006788-kz8i4a6h	304	1	factor-21	factor-21	CC
cord-006788-kz8i4a6h	304	2	prevents	prevent	VBZ
cord-006788-kz8i4a6h	304	3	diabetic	diabetic	JJ
cord-006788-kz8i4a6h	304	4	cardiomyopathy	cardiomyopathy	NN
cord-006788-kz8i4a6h	304	5	via	via	IN
cord-006788-kz8i4a6h	304	6	AMPK	AMPK	NNP
cord-006788-kz8i4a6h	304	7	-	-	HYPH
cord-006788-kz8i4a6h	304	8	mediated	mediate	VBN
cord-006788-kz8i4a6h	304	9	antioxidation	antioxidation	NN
cord-006788-kz8i4a6h	304	10	and	and	CC
cord-006788-kz8i4a6h	304	11	lipid	lipid	NN
cord-006788-kz8i4a6h	304	12	-	-	HYPH
cord-006788-kz8i4a6h	304	13	lowering	lower	VBG
cord-006788-kz8i4a6h	304	14	effects	effect	NNS
cord-006788-kz8i4a6h	304	15	in	in	IN
cord-006788-kz8i4a6h	304	16	the	the	DT
cord-006788-kz8i4a6h	304	17	heart	heart	NN
cord-006788-kz8i4a6h	304	18	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	304	19	growth	growth	NN
cord-006788-kz8i4a6h	304	20	factor	factor	NN
cord-006788-kz8i4a6h	305	1	21	21	CD
cord-006788-kz8i4a6h	305	2	protects	protect	VBZ
cord-006788-kz8i4a6h	305	3	the	the	DT
cord-006788-kz8i4a6h	305	4	heart	heart	NN
cord-006788-kz8i4a6h	305	5	from	from	IN
cord-006788-kz8i4a6h	305	6	apoptosis	apoptosis	NN
cord-006788-kz8i4a6h	305	7	in	in	IN
cord-006788-kz8i4a6h	305	8	a	a	DT
cord-006788-kz8i4a6h	305	9	diabetic	diabetic	JJ
cord-006788-kz8i4a6h	305	10	mouse	mouse	NN
cord-006788-kz8i4a6h	305	11	model	model	NN
cord-006788-kz8i4a6h	305	12	via	via	IN
cord-006788-kz8i4a6h	305	13	extracellular	extracellular	JJ
cord-006788-kz8i4a6h	305	14	signal	signal	NN
cord-006788-kz8i4a6h	305	15	-	-	HYPH
cord-006788-kz8i4a6h	305	16	regulated	regulate	VBN
cord-006788-kz8i4a6h	305	17	kinase	kinase	NN
cord-006788-kz8i4a6h	305	18	1/2-dependent	1/2-dependent	CD
cord-006788-kz8i4a6h	305	19	signalling	signal	VBG
cord-006788-kz8i4a6h	305	20	pathway	pathway	NN
cord-006788-kz8i4a6h	306	1	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	306	2	prevents	prevent	VBZ
cord-006788-kz8i4a6h	306	3	angiotensin	angiotensin	NNP
cord-006788-kz8i4a6h	306	4	II	II	NNP
cord-006788-kz8i4a6h	306	5	-	-	HYPH
cord-006788-kz8i4a6h	306	6	induced	induce	VBN
cord-006788-kz8i4a6h	306	7	hypertension	hypertension	NN
cord-006788-kz8i4a6h	306	8	and	and	CC
cord-006788-kz8i4a6h	306	9	vascular	vascular	JJ
cord-006788-kz8i4a6h	306	10	dysfunction	dysfunction	NN
cord-006788-kz8i4a6h	306	11	by	by	IN
cord-006788-kz8i4a6h	306	12	activation	activation	NN
cord-006788-kz8i4a6h	306	13	of	of	IN
cord-006788-kz8i4a6h	306	14	ACE2	ACE2	NNP
cord-006788-kz8i4a6h	306	15	/	/	SYM
cord-006788-kz8i4a6h	306	16	angiotensin-(1	angiotensin-(1	CD
cord-006788-kz8i4a6h	306	17	-	-	SYM
cord-006788-kz8i4a6h	306	18	7	7	CD
cord-006788-kz8i4a6h	306	19	)	)	-RRB-
cord-006788-kz8i4a6h	306	20	axis	axis	NN
cord-006788-kz8i4a6h	306	21	in	in	IN
cord-006788-kz8i4a6h	306	22	mice	mouse	NNS
cord-006788-kz8i4a6h	307	1	Autophagy	Autophagy	NNP
cord-006788-kz8i4a6h	307	2	deficiency	deficiency	NN
cord-006788-kz8i4a6h	307	3	leads	lead	VBZ
cord-006788-kz8i4a6h	307	4	to	to	IN
cord-006788-kz8i4a6h	307	5	protection	protection	NN
cord-006788-kz8i4a6h	307	6	from	from	IN
cord-006788-kz8i4a6h	307	7	obesity	obesity	NN
cord-006788-kz8i4a6h	307	8	and	and	CC
cord-006788-kz8i4a6h	307	9	insulin	insulin	NN
cord-006788-kz8i4a6h	307	10	resistance	resistance	NN
cord-006788-kz8i4a6h	307	11	by	by	IN
cord-006788-kz8i4a6h	307	12	inducing	induce	VBG
cord-006788-kz8i4a6h	307	13	Fgf21	Fgf21	NNP
cord-006788-kz8i4a6h	307	14	as	as	IN
cord-006788-kz8i4a6h	307	15	a	a	DT
cord-006788-kz8i4a6h	307	16	mitokine	mitokine	NN
cord-006788-kz8i4a6h	307	17	FGF-21	FGF-21	NNP
cord-006788-kz8i4a6h	307	18	as	as	IN
cord-006788-kz8i4a6h	307	19	a	a	DT
cord-006788-kz8i4a6h	307	20	biomarker	biomarker	NN
cord-006788-kz8i4a6h	307	21	for	for	IN
cord-006788-kz8i4a6h	307	22	muscle	muscle	NN
cord-006788-kz8i4a6h	307	23	-	-	HYPH
cord-006788-kz8i4a6h	307	24	manifesting	manifest	VBG
cord-006788-kz8i4a6h	307	25	mitochondrial	mitochondrial	JJ
cord-006788-kz8i4a6h	307	26	respiratory	respiratory	JJ
cord-006788-kz8i4a6h	307	27	chain	chain	NN
cord-006788-kz8i4a6h	307	28	deficiencies	deficiency	NNS
cord-006788-kz8i4a6h	307	29	:	:	:
cord-006788-kz8i4a6h	307	30	a	a	DT
cord-006788-kz8i4a6h	307	31	diagnostic	diagnostic	JJ
cord-006788-kz8i4a6h	307	32	study	study	NN
cord-006788-kz8i4a6h	307	33	Exercise	exercise	NN
cord-006788-kz8i4a6h	307	34	alleviates	alleviate	VBZ
cord-006788-kz8i4a6h	307	35	obesity	obesity	NN
cord-006788-kz8i4a6h	307	36	-	-	HYPH
cord-006788-kz8i4a6h	307	37	induced	induce	VBN
cord-006788-kz8i4a6h	307	38	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	307	39	dysfunction	dysfunction	NN
cord-006788-kz8i4a6h	307	40	via	via	IN
cord-006788-kz8i4a6h	307	41	enhancing	enhance	VBG
cord-006788-kz8i4a6h	307	42	FGF21	fgf21	JJ
cord-006788-kz8i4a6h	307	43	sensitivity	sensitivity	NN
cord-006788-kz8i4a6h	307	44	in	in	IN
cord-006788-kz8i4a6h	307	45	adipose	adipose	JJ
cord-006788-kz8i4a6h	307	46	tissues	tissue	NNS
cord-006788-kz8i4a6h	307	47	OPA1	opa1	JJ
cord-006788-kz8i4a6h	307	48	deficiency	deficiency	NN
cord-006788-kz8i4a6h	307	49	promotes	promote	VBZ
cord-006788-kz8i4a6h	307	50	secretion	secretion	NN
cord-006788-kz8i4a6h	307	51	of	of	IN
cord-006788-kz8i4a6h	307	52	FGF21	fgf21	NN
cord-006788-kz8i4a6h	307	53	from	from	IN
cord-006788-kz8i4a6h	307	54	muscle	muscle	NN
cord-006788-kz8i4a6h	307	55	that	that	WDT
cord-006788-kz8i4a6h	307	56	prevents	prevent	VBZ
cord-006788-kz8i4a6h	307	57	obesity	obesity	NN
cord-006788-kz8i4a6h	307	58	and	and	CC
cord-006788-kz8i4a6h	307	59	insulin	insulin	NN
cord-006788-kz8i4a6h	307	60	resistance	resistance	NN
cord-006788-kz8i4a6h	308	1	Acute	acute	JJ
cord-006788-kz8i4a6h	308	2	exercise	exercise	NN
cord-006788-kz8i4a6h	308	3	increases	increase	VBZ
cord-006788-kz8i4a6h	308	4	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	308	5	growth	growth	NN
cord-006788-kz8i4a6h	308	6	factor	factor	NN
cord-006788-kz8i4a6h	308	7	21	21	CD
cord-006788-kz8i4a6h	308	8	in	in	IN
cord-006788-kz8i4a6h	308	9	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	308	10	organs	organ	NNS
cord-006788-kz8i4a6h	308	11	and	and	CC
cord-006788-kz8i4a6h	308	12	circulation	circulation	NN
cord-006788-kz8i4a6h	309	1	Fibroblast	fibroblast	JJ
cord-006788-kz8i4a6h	309	2	growth	growth	NN
cord-006788-kz8i4a6h	309	3	factor-21	factor-21	VBD
cord-006788-kz8i4a6h	309	4	protects	protect	VBZ
cord-006788-kz8i4a6h	309	5	human	human	JJ
cord-006788-kz8i4a6h	309	6	skeletal	skeletal	JJ
cord-006788-kz8i4a6h	309	7	muscle	muscle	NN
cord-006788-kz8i4a6h	309	8	myotubes	myotube	NNS
cord-006788-kz8i4a6h	309	9	from	from	IN
cord-006788-kz8i4a6h	309	10	palmitate	palmitate	NN
cord-006788-kz8i4a6h	309	11	-	-	HYPH
cord-006788-kz8i4a6h	309	12	induced	induce	VBN
cord-006788-kz8i4a6h	309	13	insulin	insulin	NN
cord-006788-kz8i4a6h	309	14	resistance	resistance	NN
cord-006788-kz8i4a6h	309	15	by	by	IN
cord-006788-kz8i4a6h	309	16	inhibiting	inhibit	VBG
cord-006788-kz8i4a6h	309	17	stress	stress	NN
cord-006788-kz8i4a6h	309	18	kinase	kinase	NN
cord-006788-kz8i4a6h	309	19	and	and	CC
cord-006788-kz8i4a6h	309	20	NF	NF	NNP
cord-006788-kz8i4a6h	309	21	-	-	HYPH
cord-006788-kz8i4a6h	309	22	kB	kB	NNP
cord-006788-kz8i4a6h	309	23	FGF21	fgf21	NN
cord-006788-kz8i4a6h	310	1	is	be	VBZ
cord-006788-kz8i4a6h	310	2	an	an	DT
cord-006788-kz8i4a6h	310	3	Akt	Akt	NNP
cord-006788-kz8i4a6h	310	4	-	-	HYPH
cord-006788-kz8i4a6h	310	5	regulated	regulate	VBN
cord-006788-kz8i4a6h	310	6	myokine	myokine	NN
cord-006788-kz8i4a6h	310	7	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	310	8	acts	act	VBZ
cord-006788-kz8i4a6h	310	9	centrally	centrally	RB
cord-006788-kz8i4a6h	310	10	to	to	TO
cord-006788-kz8i4a6h	310	11	induce	induce	VB
cord-006788-kz8i4a6h	310	12	sympathetic	sympathetic	JJ
cord-006788-kz8i4a6h	310	13	nerve	nerve	NN
cord-006788-kz8i4a6h	310	14	activity	activity	NN
cord-006788-kz8i4a6h	310	15	,	,	,
cord-006788-kz8i4a6h	310	16	energy	energy	NN
cord-006788-kz8i4a6h	310	17	expenditure	expenditure	NN
cord-006788-kz8i4a6h	310	18	,	,	,
cord-006788-kz8i4a6h	310	19	and	and	CC
cord-006788-kz8i4a6h	310	20	weight	weight	NN
cord-006788-kz8i4a6h	310	21	loss	loss	NN
cord-006788-kz8i4a6h	310	22	Maratos	Maratos	NNP
cord-006788-kz8i4a6h	310	23	-	-	HYPH
cord-006788-kz8i4a6h	310	24	Flier	Flier	NNP
cord-006788-kz8i4a6h	310	25	E.	E.	NNP
cord-006788-kz8i4a6h	310	26	Central	central	JJ
cord-006788-kz8i4a6h	310	27	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	310	28	growth	growth	NN
cord-006788-kz8i4a6h	310	29	factor	factor	NN
cord-006788-kz8i4a6h	310	30	21	21	CD
cord-006788-kz8i4a6h	310	31	browns	brown	NNS
cord-006788-kz8i4a6h	310	32	white	white	JJ
cord-006788-kz8i4a6h	310	33	fat	fat	NN
cord-006788-kz8i4a6h	310	34	via	via	IN
cord-006788-kz8i4a6h	310	35	sympathetic	sympathetic	JJ
cord-006788-kz8i4a6h	310	36	action	action	NN
cord-006788-kz8i4a6h	310	37	in	in	IN
cord-006788-kz8i4a6h	310	38	male	male	JJ
cord-006788-kz8i4a6h	310	39	mice	mouse	NNS
cord-006788-kz8i4a6h	311	1	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	311	2	maintains	maintain	VBZ
cord-006788-kz8i4a6h	311	3	glucose	glucose	NN
cord-006788-kz8i4a6h	311	4	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	311	5	by	by	IN
cord-006788-kz8i4a6h	311	6	mediating	mediate	VBG
cord-006788-kz8i4a6h	311	7	the	the	DT
cord-006788-kz8i4a6h	311	8	cross	cross	NN
cord-006788-kz8i4a6h	311	9	talk	talk	NN
cord-006788-kz8i4a6h	311	10	between	between	IN
cord-006788-kz8i4a6h	311	11	liver	liver	NN
cord-006788-kz8i4a6h	311	12	and	and	CC
cord-006788-kz8i4a6h	311	13	brain	brain	NN
cord-006788-kz8i4a6h	311	14	during	during	IN
cord-006788-kz8i4a6h	311	15	prolonged	prolong	VBN
cord-006788-kz8i4a6h	311	16	fasting	fast	VBG
cord-006788-kz8i4a6h	311	17	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	311	18	contributes	contribute	VBZ
cord-006788-kz8i4a6h	311	19	to	to	IN
cord-006788-kz8i4a6h	311	20	neuroendocrine	neuroendocrine	JJ
cord-006788-kz8i4a6h	311	21	control	control	NN
cord-006788-kz8i4a6h	311	22	of	of	IN
cord-006788-kz8i4a6h	311	23	female	female	JJ
cord-006788-kz8i4a6h	311	24	reproduction	reproduction	NN
cord-006788-kz8i4a6h	312	1	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	312	2	regulates	regulate	VBZ
cord-006788-kz8i4a6h	312	3	metabolism	metabolism	NN
cord-006788-kz8i4a6h	312	4	and	and	CC
cord-006788-kz8i4a6h	312	5	circadian	circadian	NN
cord-006788-kz8i4a6h	312	6	behavior	behavior	NN
cord-006788-kz8i4a6h	312	7	by	by	IN
cord-006788-kz8i4a6h	312	8	acting	act	VBG
cord-006788-kz8i4a6h	312	9	on	on	IN
cord-006788-kz8i4a6h	312	10	the	the	DT
cord-006788-kz8i4a6h	312	11	nervous	nervous	JJ
cord-006788-kz8i4a6h	312	12	system	system	NN
cord-006788-kz8i4a6h	312	13	Role	role	NN
cord-006788-kz8i4a6h	312	14	of	of	IN
cord-006788-kz8i4a6h	312	15	PPARα	PPARα	NNS
cord-006788-kz8i4a6h	312	16	in	in	IN
cord-006788-kz8i4a6h	312	17	the	the	DT
cord-006788-kz8i4a6h	312	18	control	control	NN
cord-006788-kz8i4a6h	312	19	of	of	IN
cord-006788-kz8i4a6h	312	20	torpor	torpor	NN
cord-006788-kz8i4a6h	312	21	through	through	IN
cord-006788-kz8i4a6h	312	22	FGF21-NPY	fgf21-npy	NN
cord-006788-kz8i4a6h	312	23	pathway	pathway	NN
cord-006788-kz8i4a6h	312	24	:	:	:
cord-006788-kz8i4a6h	312	25	from	from	IN
cord-006788-kz8i4a6h	312	26	circadian	circadian	NN
cord-006788-kz8i4a6h	312	27	clock	clock	NN
cord-006788-kz8i4a6h	312	28	to	to	IN
cord-006788-kz8i4a6h	312	29	seasonal	seasonal	JJ
cord-006788-kz8i4a6h	312	30	change	change	NN
cord-006788-kz8i4a6h	312	31	in	in	IN
cord-006788-kz8i4a6h	312	32	mammals	mammal	NNS
cord-006788-kz8i4a6h	313	1	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	313	2	attenuates	attenuate	VBZ
cord-006788-kz8i4a6h	313	3	high	high	JJ
cord-006788-kz8i4a6h	313	4	-	-	HYPH
cord-006788-kz8i4a6h	313	5	fat	fat	NN
cord-006788-kz8i4a6h	313	6	diet	diet	NN
cord-006788-kz8i4a6h	313	7	-	-	HYPH
cord-006788-kz8i4a6h	313	8	induced	induce	VBN
cord-006788-kz8i4a6h	313	9	cognitive	cognitive	JJ
cord-006788-kz8i4a6h	313	10	impairment	impairment	NN
cord-006788-kz8i4a6h	313	11	via	via	IN
cord-006788-kz8i4a6h	313	12	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	313	13	regulation	regulation	NN
cord-006788-kz8i4a6h	313	14	and	and	CC
cord-006788-kz8i4a6h	313	15	anti	anti	JJ
cord-006788-kz8i4a6h	313	16	-	-	JJ
cord-006788-kz8i4a6h	313	17	inflammation	inflammation	NN
cord-006788-kz8i4a6h	313	18	of	of	IN
cord-006788-kz8i4a6h	313	19	obese	obese	JJ
cord-006788-kz8i4a6h	313	20	mice	mouse	NNS
cord-006788-kz8i4a6h	313	21	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	313	22	growth	growth	NN
cord-006788-kz8i4a6h	313	23	factor	factor	NN
cord-006788-kz8i4a6h	313	24	21	21	CD
cord-006788-kz8i4a6h	314	1	protects	protect	VBZ
cord-006788-kz8i4a6h	314	2	mouse	mouse	NN
cord-006788-kz8i4a6h	314	3	brain	brain	NN
cord-006788-kz8i4a6h	314	4	against	against	IN
cord-006788-kz8i4a6h	314	5	D	d	NN
cord-006788-kz8i4a6h	314	6	-	-	HYPH
cord-006788-kz8i4a6h	314	7	galactose	galactose	NN
cord-006788-kz8i4a6h	314	8	induced	induce	VBN
cord-006788-kz8i4a6h	314	9	aging	age	VBG
cord-006788-kz8i4a6h	314	10	via	via	IN
cord-006788-kz8i4a6h	314	11	suppression	suppression	NN
cord-006788-kz8i4a6h	314	12	of	of	IN
cord-006788-kz8i4a6h	314	13	oxidative	oxidative	JJ
cord-006788-kz8i4a6h	314	14	stress	stress	NN
cord-006788-kz8i4a6h	314	15	response	response	NN
cord-006788-kz8i4a6h	314	16	and	and	CC
cord-006788-kz8i4a6h	314	17	advanced	advanced	JJ
cord-006788-kz8i4a6h	314	18	glycation	glycation	NN
cord-006788-kz8i4a6h	314	19	end	end	NN
cord-006788-kz8i4a6h	314	20	products	product	NNS
cord-006788-kz8i4a6h	314	21	formation	formation	NN
cord-006788-kz8i4a6h	314	22	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	314	23	growth	growth	NN
cord-006788-kz8i4a6h	314	24	factor	factor	NN
cord-006788-kz8i4a6h	314	25	21	21	CD
cord-006788-kz8i4a6h	314	26	action	action	NN
cord-006788-kz8i4a6h	314	27	in	in	IN
cord-006788-kz8i4a6h	314	28	the	the	DT
cord-006788-kz8i4a6h	314	29	brain	brain	NN
cord-006788-kz8i4a6h	314	30	increases	increase	VBZ
cord-006788-kz8i4a6h	314	31	energy	energy	NN
cord-006788-kz8i4a6h	314	32	expenditure	expenditure	NN
cord-006788-kz8i4a6h	314	33	and	and	CC
cord-006788-kz8i4a6h	314	34	insulin	insulin	NN
cord-006788-kz8i4a6h	314	35	sensitivity	sensitivity	NN
cord-006788-kz8i4a6h	314	36	in	in	IN
cord-006788-kz8i4a6h	314	37	obese	obese	JJ
cord-006788-kz8i4a6h	314	38	rats	rat	NNS
cord-006788-kz8i4a6h	315	1	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	315	2	promotes	promote	VBZ
cord-006788-kz8i4a6h	315	3	metabolic	metabolic	JJ
cord-006788-kz8i4a6h	315	4	homeostasis	homeostasis	NN
cord-006788-kz8i4a6h	315	5	via	via	IN
cord-006788-kz8i4a6h	315	6	white	white	JJ
cord-006788-kz8i4a6h	315	7	adipose	adipose	NN
cord-006788-kz8i4a6h	315	8	and	and	CC
cord-006788-kz8i4a6h	315	9	leptin	leptin	NN
cord-006788-kz8i4a6h	315	10	in	in	IN
cord-006788-kz8i4a6h	316	1	mice	mouse	NNS
cord-006788-kz8i4a6h	316	2	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	316	3	growth	growth	NN
cord-006788-kz8i4a6h	316	4	factor	factor	NN
cord-006788-kz8i4a6h	316	5	21	21	CD
cord-006788-kz8i4a6h	316	6	reverses	reverse	VBZ
cord-006788-kz8i4a6h	316	7	hepatic	hepatic	JJ
cord-006788-kz8i4a6h	316	8	steatosis	steatosis	NN
cord-006788-kz8i4a6h	316	9	,	,	,
cord-006788-kz8i4a6h	316	10	increases	increase	VBZ
cord-006788-kz8i4a6h	316	11	energy	energy	NN
cord-006788-kz8i4a6h	316	12	expenditure	expenditure	NN
cord-006788-kz8i4a6h	316	13	,	,	,
cord-006788-kz8i4a6h	316	14	and	and	CC
cord-006788-kz8i4a6h	316	15	improves	improve	VBZ
cord-006788-kz8i4a6h	316	16	insulin	insulin	NN
cord-006788-kz8i4a6h	316	17	sensitivity	sensitivity	NN
cord-006788-kz8i4a6h	316	18	in	in	IN
cord-006788-kz8i4a6h	316	19	diet	diet	NN
cord-006788-kz8i4a6h	316	20	-	-	HYPH
cord-006788-kz8i4a6h	316	21	induced	induce	VBN
cord-006788-kz8i4a6h	316	22	obese	obese	JJ
cord-006788-kz8i4a6h	316	23	mice	mouse	NNS
cord-006788-kz8i4a6h	316	24	Loss	loss	NN
cord-006788-kz8i4a6h	316	25	of	of	IN
cord-006788-kz8i4a6h	316	26	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	316	27	growth	growth	NN
cord-006788-kz8i4a6h	316	28	factor	factor	NN
cord-006788-kz8i4a6h	316	29	21	21	CD
cord-006788-kz8i4a6h	316	30	action	action	NN
cord-006788-kz8i4a6h	316	31	induces	induce	VBZ
cord-006788-kz8i4a6h	316	32	insulin	insulin	NN
cord-006788-kz8i4a6h	316	33	resistance	resistance	NN
cord-006788-kz8i4a6h	316	34	,	,	,
cord-006788-kz8i4a6h	316	35	pancreatic	pancreatic	JJ
cord-006788-kz8i4a6h	316	36	islet	islet	NN
cord-006788-kz8i4a6h	316	37	hyperplasia	hyperplasia	NN
cord-006788-kz8i4a6h	316	38	and	and	CC
cord-006788-kz8i4a6h	316	39	dysfunction	dysfunction	NN
cord-006788-kz8i4a6h	316	40	in	in	IN
cord-006788-kz8i4a6h	316	41	mice	mouse	NNS
cord-006788-kz8i4a6h	316	42	Attenuation	attenuation	NN
cord-006788-kz8i4a6h	316	43	of	of	IN
cord-006788-kz8i4a6h	316	44	hyperlipidemia	hyperlipidemia	NN
cord-006788-kz8i4a6h	316	45	-	-	HYPH
cord-006788-kz8i4a6h	316	46	and	and	CC
cord-006788-kz8i4a6h	316	47	diabetes	diabetes	NN
cord-006788-kz8i4a6h	316	48	-	-	HYPH
cord-006788-kz8i4a6h	316	49	induced	induce	VBN
cord-006788-kz8i4a6h	316	50	early	early	JJ
cord-006788-kz8i4a6h	316	51	-	-	HYPH
cord-006788-kz8i4a6h	316	52	stage	stage	NN
cord-006788-kz8i4a6h	316	53	apoptosis	apoptosis	NN
cord-006788-kz8i4a6h	316	54	and	and	CC
cord-006788-kz8i4a6h	316	55	late	late	JJ
cord-006788-kz8i4a6h	316	56	-	-	HYPH
cord-006788-kz8i4a6h	316	57	stage	stage	NN
cord-006788-kz8i4a6h	316	58	renal	renal	JJ
cord-006788-kz8i4a6h	316	59	dysfunction	dysfunction	NN
cord-006788-kz8i4a6h	316	60	via	via	IN
cord-006788-kz8i4a6h	316	61	administration	administration	NN
cord-006788-kz8i4a6h	316	62	of	of	IN
cord-006788-kz8i4a6h	316	63	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	316	64	growth	growth	NN
cord-006788-kz8i4a6h	317	1	factor-21	factor-21	NNP
cord-006788-kz8i4a6h	317	2	is	be	VBZ
cord-006788-kz8i4a6h	317	3	associated	associate	VBN
cord-006788-kz8i4a6h	317	4	with	with	IN
cord-006788-kz8i4a6h	317	5	suppression	suppression	NN
cord-006788-kz8i4a6h	317	6	of	of	IN
cord-006788-kz8i4a6h	317	7	renal	renal	JJ
cord-006788-kz8i4a6h	317	8	inflammation	inflammation	NN
cord-006788-kz8i4a6h	317	9	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	317	10	growth	growth	NN
cord-006788-kz8i4a6h	317	11	factor	factor	NN
cord-006788-kz8i4a6h	317	12	21	21	CD
cord-006788-kz8i4a6h	317	13	improves	improve	VBZ
cord-006788-kz8i4a6h	317	14	insulin	insulin	NN
cord-006788-kz8i4a6h	317	15	resistance	resistance	NN
cord-006788-kz8i4a6h	317	16	and	and	CC
cord-006788-kz8i4a6h	317	17	ameliorates	ameliorate	VBZ
cord-006788-kz8i4a6h	317	18	renal	renal	JJ
cord-006788-kz8i4a6h	317	19	injury	injury	NN
cord-006788-kz8i4a6h	317	20	in	in	IN
cord-006788-kz8i4a6h	318	1	db	db	NNP
cord-006788-kz8i4a6h	318	2	/	/	SYM
cord-006788-kz8i4a6h	318	3	db	db	NNP
cord-006788-kz8i4a6h	318	4	mice	mouse	NNS
cord-006788-kz8i4a6h	318	5	Liver	liver	NN
cord-006788-kz8i4a6h	318	6	-	-	HYPH
cord-006788-kz8i4a6h	318	7	heart	heart	NN
cord-006788-kz8i4a6h	318	8	crosstalk	crosstalk	NN
cord-006788-kz8i4a6h	318	9	controls	control	VBZ
cord-006788-kz8i4a6h	318	10	IL-22	IL-22	NNP
cord-006788-kz8i4a6h	318	11	activity	activity	NN
cord-006788-kz8i4a6h	318	12	in	in	IN
cord-006788-kz8i4a6h	318	13	cardiac	cardiac	JJ
cord-006788-kz8i4a6h	318	14	protection	protection	NN
cord-006788-kz8i4a6h	318	15	after	after	IN
cord-006788-kz8i4a6h	318	16	myocardial	myocardial	JJ
cord-006788-kz8i4a6h	318	17	infarction	infarction	NN
cord-006788-kz8i4a6h	318	18	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	318	19	growth	growth	NN
cord-006788-kz8i4a6h	318	20	factor	factor	NN
cord-006788-kz8i4a6h	318	21	21	21	CD
cord-006788-kz8i4a6h	318	22	ameliorates	ameliorate	VBZ
cord-006788-kz8i4a6h	318	23	pancreatic	pancreatic	NN
cord-006788-kz8i4a6h	318	24	fibrogenesis	fibrogenesis	NN
cord-006788-kz8i4a6h	318	25	via	via	IN
cord-006788-kz8i4a6h	318	26	regulating	regulate	VBG
cord-006788-kz8i4a6h	318	27	polarization	polarization	NN
cord-006788-kz8i4a6h	318	28	of	of	IN
cord-006788-kz8i4a6h	318	29	macrophages	macrophage	NNS
cord-006788-kz8i4a6h	318	30	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	318	31	growth	growth	NN
cord-006788-kz8i4a6h	318	32	factor	factor	NN
cord-006788-kz8i4a6h	318	33	21	21	CD
cord-006788-kz8i4a6h	318	34	ameliorates	ameliorate	VBZ
cord-006788-kz8i4a6h	318	35	high	high	JJ
cord-006788-kz8i4a6h	318	36	glucose	glucose	NN
cord-006788-kz8i4a6h	318	37	-	-	HYPH
cord-006788-kz8i4a6h	318	38	induced	induce	VBN
cord-006788-kz8i4a6h	318	39	fibrogenesis	fibrogenesis	NN
cord-006788-kz8i4a6h	318	40	in	in	IN
cord-006788-kz8i4a6h	318	41	mesangial	mesangial	JJ
cord-006788-kz8i4a6h	318	42	cells	cell	NNS
cord-006788-kz8i4a6h	318	43	through	through	IN
cord-006788-kz8i4a6h	318	44	inhibiting	inhibit	VBG
cord-006788-kz8i4a6h	318	45	STAT5	stat5	RB
cord-006788-kz8i4a6h	318	46	signaling	signal	VBG
cord-006788-kz8i4a6h	318	47	pathway	pathway	NN
cord-006788-kz8i4a6h	318	48	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	318	49	growth	growth	NN
cord-006788-kz8i4a6h	318	50	factor	factor	NN
cord-006788-kz8i4a6h	318	51	21	21	CD
cord-006788-kz8i4a6h	319	1	regulates	regulate	VBZ
cord-006788-kz8i4a6h	319	2	glucose	glucose	NN
cord-006788-kz8i4a6h	319	3	metabolism	metabolism	NN
cord-006788-kz8i4a6h	319	4	in	in	IN
cord-006788-kz8i4a6h	319	5	part	part	NN
cord-006788-kz8i4a6h	319	6	by	by	IN
cord-006788-kz8i4a6h	319	7	reducing	reduce	VBG
cord-006788-kz8i4a6h	320	1	renal	renal	JJ
cord-006788-kz8i4a6h	320	2	glucose	glucose	NN
cord-006788-kz8i4a6h	320	3	reabsorption	reabsorption	NN
cord-006788-kz8i4a6h	320	4	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	320	5	increases	increase	VBZ
cord-006788-kz8i4a6h	320	6	cholesterol	cholesterol	NN
cord-006788-kz8i4a6h	320	7	efflux	efflux	NN
cord-006788-kz8i4a6h	320	8	by	by	IN
cord-006788-kz8i4a6h	320	9	upregulating	upregulate	VBG
cord-006788-kz8i4a6h	320	10	ABCA1	abca1	XX
cord-006788-kz8i4a6h	320	11	through	through	IN
cord-006788-kz8i4a6h	320	12	the	the	DT
cord-006788-kz8i4a6h	320	13	ERK1/2-PPARg	ERK1/2-PPARg	NNP
cord-006788-kz8i4a6h	320	14	-	-	HYPH
cord-006788-kz8i4a6h	320	15	LXRα	LXRα	NNP
cord-006788-kz8i4a6h	320	16	pathway	pathway	NN
cord-006788-kz8i4a6h	320	17	in	in	IN
cord-006788-kz8i4a6h	320	18	THP1	THP1	NNP
cord-006788-kz8i4a6h	320	19	macrophage	macrophage	NN
cord-006788-kz8i4a6h	320	20	-	-	HYPH
cord-006788-kz8i4a6h	320	21	derived	derive	VBN
cord-006788-kz8i4a6h	320	22	foam	foam	NN
cord-006788-kz8i4a6h	320	23	cells	cell	NNS
cord-006788-kz8i4a6h	320	24	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	320	25	growth	growth	NN
cord-006788-kz8i4a6h	320	26	factor	factor	NN
cord-006788-kz8i4a6h	320	27	21	21	CD
cord-006788-kz8i4a6h	320	28	(	(	-LRB-
cord-006788-kz8i4a6h	320	29	FGF21	fgf21	NN
cord-006788-kz8i4a6h	320	30	)	)	-RRB-
cord-006788-kz8i4a6h	321	1	inhibits	inhibit	VBZ
cord-006788-kz8i4a6h	321	2	macrophage	macrophage	NN
cord-006788-kz8i4a6h	321	3	-	-	HYPH
cord-006788-kz8i4a6h	321	4	mediated	mediate	VBN
cord-006788-kz8i4a6h	321	5	inflammation	inflammation	NN
cord-006788-kz8i4a6h	321	6	by	by	IN
cord-006788-kz8i4a6h	321	7	activating	activate	VBG
cord-006788-kz8i4a6h	321	8	Nrf2	Nrf2	NNP
cord-006788-kz8i4a6h	321	9	and	and	CC
cord-006788-kz8i4a6h	321	10	suppressing	suppress	VBG
cord-006788-kz8i4a6h	321	11	the	the	DT
cord-006788-kz8i4a6h	321	12	NF	NF	NNP
cord-006788-kz8i4a6h	321	13	-	-	HYPH
cord-006788-kz8i4a6h	321	14	kB	kB	NNP
cord-006788-kz8i4a6h	321	15	signaling	signal	VBG
cord-006788-kz8i4a6h	321	16	pathway	pathway	NN
cord-006788-kz8i4a6h	321	17	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	321	18	growth	growth	NN
cord-006788-kz8i4a6h	321	19	factor	factor	NN
cord-006788-kz8i4a6h	322	1	21	21	CD
cord-006788-kz8i4a6h	322	2	increases	increase	NNS
cord-006788-kz8i4a6h	322	3	insulin	insulin	NN
cord-006788-kz8i4a6h	322	4	sensitivity	sensitivity	NN
cord-006788-kz8i4a6h	322	5	through	through	IN
cord-006788-kz8i4a6h	322	6	specific	specific	JJ
cord-006788-kz8i4a6h	322	7	expansion	expansion	NN
cord-006788-kz8i4a6h	322	8	of	of	IN
cord-006788-kz8i4a6h	322	9	subcutaneous	subcutaneous	JJ
cord-006788-kz8i4a6h	322	10	fat	fat	JJ
cord-006788-kz8i4a6h	322	11	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	322	12	growth	growth	NN
cord-006788-kz8i4a6h	322	13	factor	factor	NN
cord-006788-kz8i4a6h	322	14	21	21	CD
cord-006788-kz8i4a6h	322	15	expressions	expression	NNS
cord-006788-kz8i4a6h	322	16	in	in	IN
cord-006788-kz8i4a6h	322	17	white	white	JJ
cord-006788-kz8i4a6h	322	18	blood	blood	NN
cord-006788-kz8i4a6h	322	19	cells	cell	NNS
cord-006788-kz8i4a6h	322	20	and	and	CC
cord-006788-kz8i4a6h	322	21	sera	sera	NNP
cord-006788-kz8i4a6h	322	22	of	of	IN
cord-006788-kz8i4a6h	322	23	patients	patient	NNS
cord-006788-kz8i4a6h	322	24	with	with	IN
cord-006788-kz8i4a6h	322	25	gestational	gestational	JJ
cord-006788-kz8i4a6h	322	26	diabetes	diabetes	NN
cord-006788-kz8i4a6h	322	27	mellitus	mellitus	NN
cord-006788-kz8i4a6h	322	28	during	during	IN
cord-006788-kz8i4a6h	322	29	gestation	gestation	NN
cord-006788-kz8i4a6h	322	30	and	and	CC
cord-006788-kz8i4a6h	322	31	postpartum	postpartum	NN
cord-006788-kz8i4a6h	322	32	FGF-21	FGF-21	NNP
cord-006788-kz8i4a6h	322	33	elevated	elevated	JJ
cord-006788-kz8i4a6h	322	34	IL-10	IL-10	NNP
cord-006788-kz8i4a6h	322	35	production	production	NN
cord-006788-kz8i4a6h	322	36	to	to	TO
cord-006788-kz8i4a6h	322	37	correct	correct	VB
cord-006788-kz8i4a6h	322	38	LPSinduced	lpsinduced	JJ
cord-006788-kz8i4a6h	322	39	inflammation	inflammation	NN
cord-006788-kz8i4a6h	323	1	A	a	DT
cord-006788-kz8i4a6h	323	2	novel	novel	JJ
cord-006788-kz8i4a6h	323	3	function	function	NN
cord-006788-kz8i4a6h	323	4	for	for	IN
cord-006788-kz8i4a6h	323	5	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	323	6	growth	growth	NN
cord-006788-kz8i4a6h	323	7	factor	factor	NN
cord-006788-kz8i4a6h	323	8	21	21	CD
cord-006788-kz8i4a6h	323	9	:	:	:
cord-006788-kz8i4a6h	323	10	stimulation	stimulation	NN
cord-006788-kz8i4a6h	323	11	of	of	IN
cord-006788-kz8i4a6h	323	12	NADPH	NADPH	NNP
cord-006788-kz8i4a6h	323	13	oxidase	oxidase	NN
cord-006788-kz8i4a6h	323	14	-	-	HYPH
cord-006788-kz8i4a6h	323	15	dependent	dependent	JJ
cord-006788-kz8i4a6h	323	16	ROS	ROS	NNP
cord-006788-kz8i4a6h	323	17	generation	generation	NN
cord-006788-kz8i4a6h	323	18	Treatment	treatment	NN
cord-006788-kz8i4a6h	323	19	of	of	IN
cord-006788-kz8i4a6h	323	20	CIA	CIA	NNP
cord-006788-kz8i4a6h	323	21	mice	mouse	NNS
cord-006788-kz8i4a6h	323	22	with	with	IN
cord-006788-kz8i4a6h	323	23	FGF21	FGF21	NNP
cord-006788-kz8i4a6h	323	24	down	down	RB
cord-006788-kz8i4a6h	323	25	-	-	HYPH
cord-006788-kz8i4a6h	323	26	regulates	regulate	NNS
cord-006788-kz8i4a6h	324	1	TH17-IL-17	th17-il-17	DT
cord-006788-kz8i4a6h	324	2	axis	axis	NN
cord-006788-kz8i4a6h	324	3	Human	human	JJ
cord-006788-kz8i4a6h	324	4	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	324	5	growth	growth	NN
cord-006788-kz8i4a6h	324	6	factor-23	factor-23	CD
cord-006788-kz8i4a6h	324	7	mutants	mutant	NNS
cord-006788-kz8i4a6h	324	8	suppress	suppress	VBP
cord-006788-kz8i4a6h	325	1	Na	Na	NNP
cord-006788-kz8i4a6h	325	2	+	+	CC
cord-006788-kz8i4a6h	325	3	-dependent	-dependent	JJ
cord-006788-kz8i4a6h	325	4	phosphate	phosphate	NN
cord-006788-kz8i4a6h	325	5	co	co	NN
cord-006788-kz8i4a6h	325	6	-	-	JJ
cord-006788-kz8i4a6h	325	7	transport	transport	JJ
cord-006788-kz8i4a6h	325	8	activity	activity	NN
cord-006788-kz8i4a6h	325	9	and	and	CC
cord-006788-kz8i4a6h	325	10	1α,25-dihydroxyvitamin	1α,25-dihydroxyvitamin	CD
cord-006788-kz8i4a6h	325	11	D3	D3	NNP
cord-006788-kz8i4a6h	325	12	production	production	NN
cord-006788-kz8i4a6h	325	13	Targeted	target	VBN
cord-006788-kz8i4a6h	325	14	ablation	ablation	NN
cord-006788-kz8i4a6h	325	15	of	of	IN
cord-006788-kz8i4a6h	325	16	Fgf23	Fgf23	NNP
cord-006788-kz8i4a6h	325	17	demonstrates	demonstrate	VBZ
cord-006788-kz8i4a6h	325	18	an	an	DT
cord-006788-kz8i4a6h	325	19	essential	essential	JJ
cord-006788-kz8i4a6h	325	20	physiological	physiological	JJ
cord-006788-kz8i4a6h	325	21	role	role	NN
cord-006788-kz8i4a6h	325	22	of	of	IN
cord-006788-kz8i4a6h	325	23	FGF23	fgf23	NN
cord-006788-kz8i4a6h	325	24	in	in	IN
cord-006788-kz8i4a6h	325	25	phosphate	phosphate	NN
cord-006788-kz8i4a6h	325	26	and	and	CC
cord-006788-kz8i4a6h	325	27	vitamin	vitamin	NN
cord-006788-kz8i4a6h	325	28	D	d	NN
cord-006788-kz8i4a6h	325	29	metabolism	metabolism	NN
cord-006788-kz8i4a6h	325	30	Cloning	cloning	NN
cord-006788-kz8i4a6h	325	31	and	and	CC
cord-006788-kz8i4a6h	325	32	characterization	characterization	NN
cord-006788-kz8i4a6h	325	33	of	of	IN
cord-006788-kz8i4a6h	325	34	FGF23	fgf23	NN
cord-006788-kz8i4a6h	325	35	as	as	IN
cord-006788-kz8i4a6h	325	36	a	a	DT
cord-006788-kz8i4a6h	325	37	causative	causative	JJ
cord-006788-kz8i4a6h	325	38	factor	factor	NN
cord-006788-kz8i4a6h	325	39	of	of	IN
cord-006788-kz8i4a6h	325	40	tumor	tumor	NN
cord-006788-kz8i4a6h	325	41	-	-	HYPH
cord-006788-kz8i4a6h	325	42	induced	induce	VBN
cord-006788-kz8i4a6h	325	43	osteomalacia	osteomalacia	NNS
cord-006788-kz8i4a6h	326	1	FGF23	fgf23	NN
cord-006788-kz8i4a6h	326	2	promotes	promote	VBZ
cord-006788-kz8i4a6h	326	3	renal	renal	JJ
cord-006788-kz8i4a6h	326	4	calcium	calcium	NN
cord-006788-kz8i4a6h	326	5	reabsorption	reabsorption	NN
cord-006788-kz8i4a6h	326	6	through	through	IN
cord-006788-kz8i4a6h	326	7	the	the	DT
cord-006788-kz8i4a6h	326	8	TRPV5	TRPV5	NNP
cord-006788-kz8i4a6h	326	9	channel	channel	NNP
cord-006788-kz8i4a6h	326	10	FGF23	FGF23	NNP
cord-006788-kz8i4a6h	326	11	regulates	regulate	VBZ
cord-006788-kz8i4a6h	326	12	renal	renal	JJ
cord-006788-kz8i4a6h	326	13	sodium	sodium	NN
cord-006788-kz8i4a6h	326	14	handling	handling	NN
cord-006788-kz8i4a6h	326	15	and	and	CC
cord-006788-kz8i4a6h	326	16	blood	blood	NN
cord-006788-kz8i4a6h	326	17	pressure	pressure	NN
cord-006788-kz8i4a6h	327	1	The	the	DT
cord-006788-kz8i4a6h	327	2	parathyroid	parathyroid	NN
cord-006788-kz8i4a6h	327	3	is	be	VBZ
cord-006788-kz8i4a6h	327	4	a	a	DT
cord-006788-kz8i4a6h	327	5	target	target	NN
cord-006788-kz8i4a6h	327	6	organ	organ	NN
cord-006788-kz8i4a6h	327	7	for	for	IN
cord-006788-kz8i4a6h	327	8	FGF23	fgf23	NN
cord-006788-kz8i4a6h	327	9	in	in	IN
cord-006788-kz8i4a6h	327	10	rats	rat	NNS
cord-006788-kz8i4a6h	327	11	Erythropoietin	Erythropoietin	VBZ
cord-006788-kz8i4a6h	327	12	induces	induce	VBZ
cord-006788-kz8i4a6h	327	13	bone	bone	NN
cord-006788-kz8i4a6h	327	14	marrow	marrow	NN
cord-006788-kz8i4a6h	327	15	and	and	CC
cord-006788-kz8i4a6h	327	16	plasma	plasma	NN
cord-006788-kz8i4a6h	327	17	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	327	18	growth	growth	NN
cord-006788-kz8i4a6h	327	19	factor	factor	NN
cord-006788-kz8i4a6h	327	20	23	23	CD
cord-006788-kz8i4a6h	327	21	during	during	IN
cord-006788-kz8i4a6h	328	1	acute	acute	JJ
cord-006788-kz8i4a6h	328	2	kidney	kidney	NN
cord-006788-kz8i4a6h	328	3	injury	injury	NN
cord-006788-kz8i4a6h	328	4	Acute	acute	JJ
cord-006788-kz8i4a6h	328	5	blood	blood	NN
cord-006788-kz8i4a6h	328	6	loss	loss	NN
cord-006788-kz8i4a6h	328	7	stimulates	stimulate	VBZ
cord-006788-kz8i4a6h	328	8	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	328	9	growth	growth	NN
cord-006788-kz8i4a6h	328	10	factor	factor	NN
cord-006788-kz8i4a6h	329	1	23	23	CD
cord-006788-kz8i4a6h	329	2	production	production	NN
cord-006788-kz8i4a6h	329	3	Autosomal	autosomal	JJ
cord-006788-kz8i4a6h	329	4	dominant	dominant	JJ
cord-006788-kz8i4a6h	329	5	hypophosphataemic	hypophosphataemic	NN
cord-006788-kz8i4a6h	329	6	rickets	ricket	NNS
cord-006788-kz8i4a6h	329	7	is	be	VBZ
cord-006788-kz8i4a6h	329	8	associated	associate	VBN
cord-006788-kz8i4a6h	329	9	with	with	IN
cord-006788-kz8i4a6h	329	10	mutations	mutation	NNS
cord-006788-kz8i4a6h	329	11	in	in	IN
cord-006788-kz8i4a6h	329	12	FGF23	FGF23	NNP
cord-006788-kz8i4a6h	329	13	FGF-23	FGF-23	NNP
cord-006788-kz8i4a6h	329	14	inhibits	inhibit	VBZ
cord-006788-kz8i4a6h	329	15	renal	renal	JJ
cord-006788-kz8i4a6h	329	16	tubular	tubular	JJ
cord-006788-kz8i4a6h	329	17	phosphate	phosphate	NN
cord-006788-kz8i4a6h	329	18	transport	transport	NN
cord-006788-kz8i4a6h	329	19	and	and	CC
cord-006788-kz8i4a6h	329	20	is	be	VBZ
cord-006788-kz8i4a6h	329	21	a	a	DT
cord-006788-kz8i4a6h	329	22	PHEX	PHEX	NNP
cord-006788-kz8i4a6h	329	23	substrate	substrate	NN
cord-006788-kz8i4a6h	329	24	FGF-23	FGF-23	NNPS
cord-006788-kz8i4a6h	329	25	in	in	IN
cord-006788-kz8i4a6h	329	26	fibrous	fibrous	JJ
cord-006788-kz8i4a6h	329	27	dysplasia	dysplasia	NN
cord-006788-kz8i4a6h	329	28	of	of	IN
cord-006788-kz8i4a6h	329	29	bone	bone	NN
cord-006788-kz8i4a6h	329	30	and	and	CC
cord-006788-kz8i4a6h	329	31	its	-PRON-	PRP$
cord-006788-kz8i4a6h	329	32	relationship	relationship	NN
cord-006788-kz8i4a6h	329	33	to	to	IN
cord-006788-kz8i4a6h	329	34	renal	renal	JJ
cord-006788-kz8i4a6h	329	35	phosphate	phosphate	NN
cord-006788-kz8i4a6h	329	36	wasting	waste	VBG
cord-006788-kz8i4a6h	329	37	Elevated	elevated	JJ
cord-006788-kz8i4a6h	329	38	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	329	39	growth	growth	NN
cord-006788-kz8i4a6h	329	40	factor-23	factor-23	NN
cord-006788-kz8i4a6h	329	41	in	in	IN
cord-006788-kz8i4a6h	329	42	hypophosphatemic	hypophosphatemic	NNP
cord-006788-kz8i4a6h	329	43	linear	linear	JJ
cord-006788-kz8i4a6h	329	44	nevus	nevus	NN
cord-006788-kz8i4a6h	329	45	sebaceous	sebaceous	NN
cord-006788-kz8i4a6h	329	46	syndrome	syndrome	NN
cord-006788-kz8i4a6h	329	47	Polypeptide	Polypeptide	NNP
cord-006788-kz8i4a6h	329	48	GalNAc	galnac	NN
cord-006788-kz8i4a6h	329	49	-	-	HYPH
cord-006788-kz8i4a6h	329	50	transferase	transferase	NN
cord-006788-kz8i4a6h	329	51	T3	T3	NNP
cord-006788-kz8i4a6h	329	52	and	and	CC
cord-006788-kz8i4a6h	329	53	familial	familial	JJ
cord-006788-kz8i4a6h	329	54	tumoral	tumoral	NNP
cord-006788-kz8i4a6h	329	55	calcinosis	calcinosis	NNP
cord-006788-kz8i4a6h	329	56	.	.	.
cord-006788-kz8i4a6h	330	1	Secretion	secretion	NN
cord-006788-kz8i4a6h	330	2	of	of	IN
cord-006788-kz8i4a6h	330	3	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	330	4	growth	growth	NN
cord-006788-kz8i4a6h	330	5	factor	factor	NN
cord-006788-kz8i4a6h	330	6	23	23	CD
cord-006788-kz8i4a6h	330	7	requires	require	VBZ
cord-006788-kz8i4a6h	330	8	O	o	NN
cord-006788-kz8i4a6h	330	9	-	-	HYPH
cord-006788-kz8i4a6h	330	10	glycosylation	glycosylation	NN
cord-006788-kz8i4a6h	330	11	Tumoral	Tumoral	NNP
cord-006788-kz8i4a6h	330	12	calcinosis	calcinosis	NN
cord-006788-kz8i4a6h	330	13	presenting	present	VBG
cord-006788-kz8i4a6h	330	14	with	with	IN
cord-006788-kz8i4a6h	330	15	eyelid	eyelid	NN
cord-006788-kz8i4a6h	330	16	calcifications	calcification	NNS
cord-006788-kz8i4a6h	330	17	due	due	JJ
cord-006788-kz8i4a6h	330	18	to	to	IN
cord-006788-kz8i4a6h	330	19	novel	novel	JJ
cord-006788-kz8i4a6h	330	20	missense	missense	NN
cord-006788-kz8i4a6h	330	21	mutations	mutation	NNS
cord-006788-kz8i4a6h	330	22	in	in	IN
cord-006788-kz8i4a6h	330	23	the	the	DT
cord-006788-kz8i4a6h	330	24	glycosyl	glycosyl	JJ
cord-006788-kz8i4a6h	330	25	transferase	transferase	NN
cord-006788-kz8i4a6h	330	26	domain	domain	NN
cord-006788-kz8i4a6h	330	27	of	of	IN
cord-006788-kz8i4a6h	330	28	the	the	DT
cord-006788-kz8i4a6h	330	29	GALNT3	GALNT3	NNP
cord-006788-kz8i4a6h	330	30	gene	gene	NN
cord-006788-kz8i4a6h	331	1	The	the	DT
cord-006788-kz8i4a6h	331	2	role	role	NN
cord-006788-kz8i4a6h	331	3	of	of	IN
cord-006788-kz8i4a6h	331	4	mutant	mutant	JJ
cord-006788-kz8i4a6h	331	5	UDP	UDP	NNP
cord-006788-kz8i4a6h	331	6	-	-	HYPH
cord-006788-kz8i4a6h	331	7	N	n	NN
cord-006788-kz8i4a6h	331	8	-	-	HYPH
cord-006788-kz8i4a6h	331	9	acetyl	acetyl	NN
cord-006788-kz8i4a6h	331	10	-	-	HYPH
cord-006788-kz8i4a6h	331	11	α	α	NN
cord-006788-kz8i4a6h	331	12	-	-	HYPH
cord-006788-kz8i4a6h	331	13	D	D	NNP
cord-006788-kz8i4a6h	331	14	-	-	HYPH
cord-006788-kz8i4a6h	331	15	galactosaminepolypeptide	galactosaminepolypeptide	NNP
cord-006788-kz8i4a6h	331	16	N	N	NNP
cord-006788-kz8i4a6h	331	17	-	-	HYPH
cord-006788-kz8i4a6h	331	18	acetylgalactosaminyltransferase	acetylgalactosaminyltransferase	NNP
cord-006788-kz8i4a6h	331	19	3	3	CD
cord-006788-kz8i4a6h	331	20	in	in	IN
cord-006788-kz8i4a6h	331	21	regulating	regulate	VBG
cord-006788-kz8i4a6h	331	22	serum	serum	NN
cord-006788-kz8i4a6h	331	23	intact	intact	JJ
cord-006788-kz8i4a6h	331	24	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	331	25	growth	growth	NN
cord-006788-kz8i4a6h	331	26	factor	factor	NN
cord-006788-kz8i4a6h	331	27	23	23	CD
cord-006788-kz8i4a6h	331	28	and	and	CC
cord-006788-kz8i4a6h	331	29	matrix	matrix	NN
cord-006788-kz8i4a6h	331	30	extracellular	extracellular	JJ
cord-006788-kz8i4a6h	331	31	phosphoglycoprotein	phosphoglycoprotein	NN
cord-006788-kz8i4a6h	331	32	in	in	IN
cord-006788-kz8i4a6h	331	33	heritable	heritable	JJ
cord-006788-kz8i4a6h	331	34	tumoral	tumoral	NNP
cord-006788-kz8i4a6h	331	35	calcinosis	calcinosis	NNP
cord-006788-kz8i4a6h	332	1	An	an	DT
cord-006788-kz8i4a6h	332	2	FGF23	fgf23	NN
cord-006788-kz8i4a6h	332	3	missense	missense	NN
cord-006788-kz8i4a6h	332	4	mutation	mutation	NN
cord-006788-kz8i4a6h	332	5	causes	cause	VBZ
cord-006788-kz8i4a6h	332	6	familial	familial	JJ
cord-006788-kz8i4a6h	332	7	tumoral	tumoral	NNP
cord-006788-kz8i4a6h	332	8	calcinosis	calcinosis	NNP
cord-006788-kz8i4a6h	332	9	with	with	IN
cord-006788-kz8i4a6h	332	10	hyperphosphatemia	hyperphosphatemia	NNP
cord-006788-kz8i4a6h	332	11	A	a	DT
cord-006788-kz8i4a6h	332	12	novel	novel	JJ
cord-006788-kz8i4a6h	332	13	homozygous	homozygous	JJ
cord-006788-kz8i4a6h	332	14	missense	missense	NN
cord-006788-kz8i4a6h	332	15	mutation	mutation	NN
cord-006788-kz8i4a6h	332	16	in	in	IN
cord-006788-kz8i4a6h	332	17	FGF23	fgf23	NN
cord-006788-kz8i4a6h	332	18	causes	cause	VBZ
cord-006788-kz8i4a6h	332	19	Familial	Familial	NNP
cord-006788-kz8i4a6h	332	20	Tumoral	Tumoral	NNP
cord-006788-kz8i4a6h	332	21	Calcinosis	Calcinosis	NNP
cord-006788-kz8i4a6h	332	22	associated	associate	VBN
cord-006788-kz8i4a6h	332	23	with	with	IN
cord-006788-kz8i4a6h	332	24	disseminated	disseminate	VBN
cord-006788-kz8i4a6h	332	25	visceral	visceral	JJ
cord-006788-kz8i4a6h	332	26	calcification	calcification	NN
cord-006788-kz8i4a6h	332	27	A	a	DT
cord-006788-kz8i4a6h	332	28	novel	novel	JJ
cord-006788-kz8i4a6h	332	29	mutation	mutation	NN
cord-006788-kz8i4a6h	332	30	in	in	IN
cord-006788-kz8i4a6h	332	31	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	332	32	growth	growth	NN
cord-006788-kz8i4a6h	332	33	factor	factor	NN
cord-006788-kz8i4a6h	332	34	23	23	CD
cord-006788-kz8i4a6h	332	35	gene	gene	NN
cord-006788-kz8i4a6h	332	36	as	as	IN
cord-006788-kz8i4a6h	332	37	a	a	DT
cord-006788-kz8i4a6h	332	38	cause	cause	NN
cord-006788-kz8i4a6h	332	39	of	of	IN
cord-006788-kz8i4a6h	332	40	tumoral	tumoral	NNP
cord-006788-kz8i4a6h	332	41	calcinosis	calcinosis	NNP
cord-006788-kz8i4a6h	333	1	A	a	DT
cord-006788-kz8i4a6h	333	2	new	new	JJ
cord-006788-kz8i4a6h	333	3	missense	missense	JJ
cord-006788-kz8i4a6h	333	4	mutation	mutation	NN
cord-006788-kz8i4a6h	333	5	in	in	IN
cord-006788-kz8i4a6h	333	6	FGF23	fgf23	NN
cord-006788-kz8i4a6h	333	7	gene	gene	NN
cord-006788-kz8i4a6h	333	8	in	in	IN
cord-006788-kz8i4a6h	333	9	a	a	DT
cord-006788-kz8i4a6h	333	10	male	male	NN
cord-006788-kz8i4a6h	333	11	with	with	IN
cord-006788-kz8i4a6h	333	12	hyperostosis	hyperostosis	NNP
cord-006788-kz8i4a6h	333	13	-	-	HYPH
cord-006788-kz8i4a6h	333	14	hyperphosphatemia	hyperphosphatemia	NNP
cord-006788-kz8i4a6h	333	15	syndrome	syndrome	NN
cord-006788-kz8i4a6h	333	16	(	(	-LRB-
cord-006788-kz8i4a6h	333	17	HHS	HHS	NNP
cord-006788-kz8i4a6h	333	18	)	)	-RRB-
cord-006788-kz8i4a6h	334	1	FGF23	fgf23	NN
cord-006788-kz8i4a6h	334	2	induces	induce	VBZ
cord-006788-kz8i4a6h	334	3	left	leave	VBD
cord-006788-kz8i4a6h	334	4	ventricular	ventricular	JJ
cord-006788-kz8i4a6h	334	5	hypertrophy	hypertrophy	NN
cord-006788-kz8i4a6h	334	6	Fibroblast	Fibroblast	NNP
cord-006788-kz8i4a6h	334	7	growth	growth	NN
cord-006788-kz8i4a6h	334	8	factor	factor	NN
cord-006788-kz8i4a6h	334	9	23	23	CD
cord-006788-kz8i4a6h	334	10	and	and	CC
cord-006788-kz8i4a6h	334	11	left	leave	VBD
cord-006788-kz8i4a6h	334	12	ventricular	ventricular	JJ
cord-006788-kz8i4a6h	334	13	hypertrophy	hypertrophy	NN
cord-006788-kz8i4a6h	334	14	in	in	IN
cord-006788-kz8i4a6h	334	15	chronic	chronic	JJ
cord-006788-kz8i4a6h	334	16	kidney	kidney	NN
cord-006788-kz8i4a6h	334	17	disease	disease	NN
cord-006788-kz8i4a6h	335	1	Circulating	circulate	VBG
cord-006788-kz8i4a6h	335	2	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	335	3	growth	growth	NN
cord-006788-kz8i4a6h	335	4	factor	factor	NN
cord-006788-kz8i4a6h	335	5	23	23	CD
cord-006788-kz8i4a6h	335	6	levels	level	NNS
cord-006788-kz8i4a6h	335	7	and	and	CC
cord-006788-kz8i4a6h	335	8	incident	incident	NN
cord-006788-kz8i4a6h	335	9	dementia	dementia	NN
cord-006788-kz8i4a6h	335	10	:	:	:
cord-006788-kz8i4a6h	335	11	The	the	DT
cord-006788-kz8i4a6h	335	12	Framingham	Framingham	NNP
cord-006788-kz8i4a6h	335	13	heart	heart	NN
cord-006788-kz8i4a6h	335	14	study	study	NN
cord-006788-kz8i4a6h	335	15	Impairment	impairment	NN
cord-006788-kz8i4a6h	335	16	of	of	IN
cord-006788-kz8i4a6h	335	17	spatial	spatial	JJ
cord-006788-kz8i4a6h	335	18	learning	learning	NN
cord-006788-kz8i4a6h	335	19	and	and	CC
cord-006788-kz8i4a6h	335	20	memory	memory	NN
cord-006788-kz8i4a6h	335	21	in	in	IN
cord-006788-kz8i4a6h	335	22	transgenic	transgenic	JJ
cord-006788-kz8i4a6h	335	23	mice	mouse	NNS
cord-006788-kz8i4a6h	335	24	overexpressing	overexpresse	VBG
cord-006788-kz8i4a6h	335	25	human	human	JJ
cord-006788-kz8i4a6h	335	26	fibroblast	fibroblast	NN
cord-006788-kz8i4a6h	335	27	growth	growth	NN
cord-006788-kz8i4a6h	335	28	factor-23	factor-23	CD