id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002806-mu9jt1ul	Tong, Mingwei	Quantitative Analysis of Cellular Proteome Alterations in CDV-Infected Mink Lung Epithelial Cells	2017-12-22		.txt	text/plain	7332	351	43	Many studies have reported the effects of CDV infections on the host cell proteins, such as inhibiting STAT1 and STAT2 nuclear import (Rothlisberger et al., 2010) , inducing cytokine responses in PBMCs (Nielsen et al., 2009) , and inducing lymphocytes apoptosis (Kumagai et al., 2004) . Based on iTRAQ combined with LC-MS/MS, a quantitative proteomic analysis was performed to identify differentially expressed proteins (DEPs) in mink lung epithelial cells (Mv.1.Lu cells) infected with CDV at 24 hours post infection (hpi). Therefore, we utilized an iTRAQ approach to identify the DEPs to further explore the pathogenic mechanism and immunomodulation of CDV infection through an analysis of the effects on host cell proteins in the mink. Collectively, the findings suggested that activation of the innate immune NF-κB signaling pathway and the NLR signaling pathway was involved in mink immune responses against CDV infection, and the NF-κB signaling was associated with the pathological respiratory or other symptoms FIGURE 5 | Confirmation of the iTRAQ-MS data by western blotting or real-time RT-PCR.	./cache/cord-002806-mu9jt1ul.txt	./txt/cord-002806-mu9jt1ul.txt