id author title date pages extension mime words sentences flesch summary cache txt cord-298240-vcph52gn Chan, Shiu-Wan The unfolded protein response in virus infections 2014-09-30 .txt text/plain 1184 63 52 This research topic collated a number of review articles and original research article, in an attempt to highlight how viruses interact with the host UPR in the establishment of acute, chronic and latent infections. The relationship between virus and UPR and its associated autophagy is being addressed in three reviews focusing on RNA viruses, as their life cycles are closely associated with the ER (Blazquez et al., 2014; Fung and Liu, 2014; Jheng et al., 2014) . An important question remains as to whether UPR represents a new tool for sensing viruses or select UPR molecules are merely being co-opted in "microbial stress response." This is being addressed in Judith Smith's review, in which she provides a critique on the intersection of the UPR with the inflammatory pathways and innate immunity and offers an insight into UPR-PRR synergy as an evolutionary adaptation to ensure specificity of anti-viral responses (Smith, 2014) . ./cache/cord-298240-vcph52gn.txt ./txt/cord-298240-vcph52gn.txt