id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-353815-w35spqqt	Huan, Yuchen	Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields	2020-10-16		.txt	text/plain	12266	623	38	This review introduces the progress of research on AMPs comprehensively and systematically, including their classification, mechanism of action, design methods, environmental factors affecting their activity, application status, prospects in various fields and problems to be solved. Tryptophan (Trp), as a non-polar amino acid, has a remarkable effect on the interface region of the lipid bilayer, whereas Arg, as a basic amino acid, confers peptide charge and hydrogen bond interactions, which are essential properties to combine with the bacterial membrane's abundant anionic component. And it seems that Trp residues play the role of natural aromatic activators of Arg-rich AMPs by ion-pair-π interactions (Walrant et al., 2020) , thereby promoting enhanced peptide-membrane interactions (Chan et al., 2006) . Furthermore, L4H4, which is designed based on the linear cationic amphiphilic peptide magainin, also shows good antibacterial activity and cell penetration properties by inserting four histidine sequences in leucine and alanine (Lointier et al., 2020) .	./cache/cord-353815-w35spqqt.txt	./txt/cord-353815-w35spqqt.txt