id sid tid token lemma pos cord-298240-vcph52gn 1 1 key key JJ cord-298240-vcph52gn 1 2 : : : cord-298240-vcph52gn 1 3 cord-298240-vcph52gn cord-298240-vcph52gn JJ cord-298240-vcph52gn 1 4 authors author NNS cord-298240-vcph52gn 1 5 : : : cord-298240-vcph52gn 1 6 Chan Chan NNP cord-298240-vcph52gn 1 7 , , , cord-298240-vcph52gn 1 8 Shiu Shiu NNP cord-298240-vcph52gn 1 9 - - HYPH cord-298240-vcph52gn 1 10 Wan Wan NNP cord-298240-vcph52gn 1 11 title title NN cord-298240-vcph52gn 1 12 : : : cord-298240-vcph52gn 1 13 The the DT cord-298240-vcph52gn 1 14 unfolded unfolded JJ cord-298240-vcph52gn 1 15 protein protein NN cord-298240-vcph52gn 1 16 response response NN cord-298240-vcph52gn 1 17 in in IN cord-298240-vcph52gn 1 18 virus virus NN cord-298240-vcph52gn 1 19 infections infection NNS cord-298240-vcph52gn 1 20 date date NN cord-298240-vcph52gn 1 21 : : : cord-298240-vcph52gn 1 22 2014 2014 CD cord-298240-vcph52gn 1 23 - - HYPH cord-298240-vcph52gn 1 24 09 09 CD cord-298240-vcph52gn 1 25 - - SYM cord-298240-vcph52gn 1 26 30 30 CD cord-298240-vcph52gn 1 27 journal journal NN cord-298240-vcph52gn 1 28 : : : cord-298240-vcph52gn 2 1 Front Front NNP cord-298240-vcph52gn 2 2 Microbiol Microbiol NNP cord-298240-vcph52gn 2 3 DOI DOI NNP cord-298240-vcph52gn 2 4 : : : cord-298240-vcph52gn 3 1 10.3389/ 10.3389/ CD cord-298240-vcph52gn 4 1 fmicb.2014.00518 fmicb.2014.00518 NFP cord-298240-vcph52gn 4 2 sha sha NNP cord-298240-vcph52gn 4 3 : : : cord-298240-vcph52gn 5 1 c9931d8718e491e3002bbf42aec7cde49e93bac5 c9931d8718e491e3002bbf42aec7cde49e93bac5 NNP cord-298240-vcph52gn 5 2 doc_id doc_id NNP cord-298240-vcph52gn 5 3 : : : cord-298240-vcph52gn 5 4 298240 298240 CD cord-298240-vcph52gn 5 5 cord_uid cord_uid NNS cord-298240-vcph52gn 5 6 : : : cord-298240-vcph52gn 6 1 vcph52gn vcph52gn NNP cord-298240-vcph52gn 7 1 nan nan NNP cord-298240-vcph52gn 7 2 Unfolded unfold VBD cord-298240-vcph52gn 7 3 protein protein NN cord-298240-vcph52gn 7 4 response response NN cord-298240-vcph52gn 7 5 ( ( -LRB- cord-298240-vcph52gn 7 6 UPR UPR NNP cord-298240-vcph52gn 7 7 ) ) -RRB- cord-298240-vcph52gn 7 8 is be VBZ cord-298240-vcph52gn 7 9 a a DT cord-298240-vcph52gn 7 10 cellular cellular JJ cord-298240-vcph52gn 7 11 homeostatic homeostatic JJ cord-298240-vcph52gn 7 12 response response NN cord-298240-vcph52gn 7 13 to to IN cord-298240-vcph52gn 7 14 endoplasmic endoplasmic NN cord-298240-vcph52gn 7 15 reticulum reticulum NN cord-298240-vcph52gn 7 16 ( ( -LRB- cord-298240-vcph52gn 7 17 ER ER NNP cord-298240-vcph52gn 7 18 ) ) -RRB- cord-298240-vcph52gn 7 19 stress stress NN cord-298240-vcph52gn 7 20 . . . cord-298240-vcph52gn 8 1 Increasing increase VBG cord-298240-vcph52gn 8 2 evidence evidence NN cord-298240-vcph52gn 8 3 suggests suggest VBZ cord-298240-vcph52gn 8 4 an an DT cord-298240-vcph52gn 8 5 intimate intimate JJ cord-298240-vcph52gn 8 6 relationship relationship NN cord-298240-vcph52gn 8 7 between between IN cord-298240-vcph52gn 8 8 virus virus NN cord-298240-vcph52gn 8 9 and and CC cord-298240-vcph52gn 8 10 UPR UPR NNP cord-298240-vcph52gn 8 11 . . . cord-298240-vcph52gn 9 1 This this DT cord-298240-vcph52gn 9 2 research research NN cord-298240-vcph52gn 9 3 topic topic NN cord-298240-vcph52gn 9 4 collated collate VBD cord-298240-vcph52gn 9 5 a a DT cord-298240-vcph52gn 9 6 number number NN cord-298240-vcph52gn 9 7 of of IN cord-298240-vcph52gn 9 8 review review NN cord-298240-vcph52gn 9 9 articles article NNS cord-298240-vcph52gn 9 10 and and CC cord-298240-vcph52gn 9 11 original original JJ cord-298240-vcph52gn 9 12 research research NN cord-298240-vcph52gn 9 13 article article NN cord-298240-vcph52gn 9 14 , , , cord-298240-vcph52gn 9 15 in in IN cord-298240-vcph52gn 9 16 an an DT cord-298240-vcph52gn 9 17 attempt attempt NN cord-298240-vcph52gn 9 18 to to TO cord-298240-vcph52gn 9 19 highlight highlight VB cord-298240-vcph52gn 9 20 how how WRB cord-298240-vcph52gn 9 21 viruses virus NNS cord-298240-vcph52gn 9 22 interact interact VBP cord-298240-vcph52gn 9 23 with with IN cord-298240-vcph52gn 9 24 the the DT cord-298240-vcph52gn 9 25 host host NN cord-298240-vcph52gn 9 26 UPR UPR NNP cord-298240-vcph52gn 9 27 in in IN cord-298240-vcph52gn 9 28 the the DT cord-298240-vcph52gn 9 29 establishment establishment NN cord-298240-vcph52gn 9 30 of of IN cord-298240-vcph52gn 9 31 acute acute JJ cord-298240-vcph52gn 9 32 , , , cord-298240-vcph52gn 9 33 chronic chronic JJ cord-298240-vcph52gn 9 34 and and CC cord-298240-vcph52gn 9 35 latent latent JJ cord-298240-vcph52gn 9 36 infections infection NNS cord-298240-vcph52gn 9 37 . . . cord-298240-vcph52gn 10 1 Virus virus NN cord-298240-vcph52gn 10 2 infection infection NN cord-298240-vcph52gn 10 3 represents represent VBZ cord-298240-vcph52gn 10 4 an an DT cord-298240-vcph52gn 10 5 arm arm NN cord-298240-vcph52gn 10 6 race race NN cord-298240-vcph52gn 10 7 between between IN cord-298240-vcph52gn 10 8 virus virus NN cord-298240-vcph52gn 10 9 and and CC cord-298240-vcph52gn 10 10 the the DT cord-298240-vcph52gn 10 11 host host NN cord-298240-vcph52gn 10 12 . . . cord-298240-vcph52gn 11 1 On on IN cord-298240-vcph52gn 11 2 one one CD cord-298240-vcph52gn 11 3 hand hand NN cord-298240-vcph52gn 11 4 , , , cord-298240-vcph52gn 11 5 the the DT cord-298240-vcph52gn 11 6 host host NN cord-298240-vcph52gn 11 7 mobilizes mobilize VBZ cord-298240-vcph52gn 11 8 the the DT cord-298240-vcph52gn 11 9 UPR UPR NNP cord-298240-vcph52gn 11 10 in in IN cord-298240-vcph52gn 11 11 an an DT cord-298240-vcph52gn 11 12 attempt attempt NN cord-298240-vcph52gn 11 13 to to TO cord-298240-vcph52gn 11 14 restrict restrict VB cord-298240-vcph52gn 11 15 virus virus NN cord-298240-vcph52gn 11 16 infection infection NN cord-298240-vcph52gn 11 17 . . . cord-298240-vcph52gn 12 1 On on IN cord-298240-vcph52gn 12 2 the the DT cord-298240-vcph52gn 12 3 other other JJ cord-298240-vcph52gn 12 4 hand hand NN cord-298240-vcph52gn 12 5 , , , cord-298240-vcph52gn 12 6 virus virus NN cord-298240-vcph52gn 12 7 subverts subvert VBZ cord-298240-vcph52gn 12 8 or or CC cord-298240-vcph52gn 12 9 even even RB cord-298240-vcph52gn 12 10 manipulates manipulate VBZ cord-298240-vcph52gn 12 11 the the DT cord-298240-vcph52gn 12 12 UPR UPR NNP cord-298240-vcph52gn 12 13 to to TO cord-298240-vcph52gn 12 14 assist assist VB cord-298240-vcph52gn 12 15 in in IN cord-298240-vcph52gn 12 16 its -PRON- PRP$ cord-298240-vcph52gn 12 17 own own JJ cord-298240-vcph52gn 12 18 infection infection NN cord-298240-vcph52gn 12 19 . . . cord-298240-vcph52gn 13 1 The the DT cord-298240-vcph52gn 13 2 consequence consequence NN cord-298240-vcph52gn 13 3 of of IN cord-298240-vcph52gn 13 4 this this DT cord-298240-vcph52gn 13 5 is be VBZ cord-298240-vcph52gn 13 6 that that IN cord-298240-vcph52gn 13 7 the the DT cord-298240-vcph52gn 13 8 UPR UPR NNP cord-298240-vcph52gn 13 9 is be VBZ cord-298240-vcph52gn 13 10 often often RB cord-298240-vcph52gn 13 11 skewed skewed JJ cord-298240-vcph52gn 13 12 during during IN cord-298240-vcph52gn 13 13 virus virus NN cord-298240-vcph52gn 13 14 infections infection NNS cord-298240-vcph52gn 13 15 to to IN cord-298240-vcph52gn 13 16 either either CC cord-298240-vcph52gn 13 17 favor favor VBP cord-298240-vcph52gn 13 18 virus virus NN cord-298240-vcph52gn 13 19 elimination elimination NN cord-298240-vcph52gn 13 20 or or CC cord-298240-vcph52gn 13 21 virus virus NN cord-298240-vcph52gn 13 22 invasion invasion NN cord-298240-vcph52gn 13 23 . . . cord-298240-vcph52gn 14 1 Whoever whoever WP cord-298240-vcph52gn 14 2 won win VBD cord-298240-vcph52gn 14 3 , , , cord-298240-vcph52gn 14 4 the the DT cord-298240-vcph52gn 14 5 outcome outcome NN cord-298240-vcph52gn 14 6 could could MD cord-298240-vcph52gn 14 7 be be VB cord-298240-vcph52gn 14 8 pathogenic pathogenic JJ cord-298240-vcph52gn 14 9 . . . cord-298240-vcph52gn 15 1 The the DT cord-298240-vcph52gn 15 2 relationship relationship NN cord-298240-vcph52gn 15 3 between between IN cord-298240-vcph52gn 15 4 virus virus NN cord-298240-vcph52gn 15 5 and and CC cord-298240-vcph52gn 15 6 UPR UPR NNP cord-298240-vcph52gn 15 7 and and CC cord-298240-vcph52gn 15 8 its -PRON- PRP$ cord-298240-vcph52gn 15 9 associated associated JJ cord-298240-vcph52gn 15 10 autophagy autophagy NN cord-298240-vcph52gn 15 11 is be VBZ cord-298240-vcph52gn 15 12 being be VBG cord-298240-vcph52gn 15 13 addressed address VBN cord-298240-vcph52gn 15 14 in in IN cord-298240-vcph52gn 15 15 three three CD cord-298240-vcph52gn 15 16 reviews review NNS cord-298240-vcph52gn 15 17 focusing focus VBG cord-298240-vcph52gn 15 18 on on IN cord-298240-vcph52gn 15 19 RNA RNA NNP cord-298240-vcph52gn 15 20 viruses virus NNS cord-298240-vcph52gn 15 21 , , , cord-298240-vcph52gn 15 22 as as IN cord-298240-vcph52gn 15 23 their -PRON- PRP$ cord-298240-vcph52gn 15 24 life life NN cord-298240-vcph52gn 15 25 cycles cycle NNS cord-298240-vcph52gn 15 26 are be VBP cord-298240-vcph52gn 15 27 closely closely RB cord-298240-vcph52gn 15 28 associated associate VBN cord-298240-vcph52gn 15 29 with with IN cord-298240-vcph52gn 15 30 the the DT cord-298240-vcph52gn 15 31 ER er NN cord-298240-vcph52gn 16 1 ( ( -LRB- cord-298240-vcph52gn 16 2 Blazquez Blazquez NNP cord-298240-vcph52gn 16 3 et et NNP cord-298240-vcph52gn 16 4 al al NNP cord-298240-vcph52gn 16 5 . . . cord-298240-vcph52gn 17 1 , , , cord-298240-vcph52gn 17 2 2014 2014 CD cord-298240-vcph52gn 17 3 ; ; : cord-298240-vcph52gn 17 4 Fung Fung NNP cord-298240-vcph52gn 17 5 and and CC cord-298240-vcph52gn 17 6 Liu Liu NNP cord-298240-vcph52gn 17 7 , , , cord-298240-vcph52gn 17 8 2014 2014 CD cord-298240-vcph52gn 17 9 ; ; : cord-298240-vcph52gn 17 10 Jheng Jheng NNP cord-298240-vcph52gn 17 11 et et NNP cord-298240-vcph52gn 17 12 al al NNP cord-298240-vcph52gn 17 13 . . NNP cord-298240-vcph52gn 17 14 , , , cord-298240-vcph52gn 17 15 2014 2014 CD cord-298240-vcph52gn 17 16 ) ) -RRB- cord-298240-vcph52gn 17 17 . . . cord-298240-vcph52gn 18 1 Miguel Miguel NNP cord-298240-vcph52gn 18 2 Martin Martin NNP cord-298240-vcph52gn 18 3 - - HYPH cord-298240-vcph52gn 18 4 Acebes Acebes NNP cord-298240-vcph52gn 18 5 and and CC cord-298240-vcph52gn 18 6 his -PRON- PRP$ cord-298240-vcph52gn 18 7 group group NN cord-298240-vcph52gn 18 8 focuses focus VBZ cord-298240-vcph52gn 18 9 on on IN cord-298240-vcph52gn 18 10 flaviviruses flavivirus NNS cord-298240-vcph52gn 18 11 whereas whereas IN cord-298240-vcph52gn 18 12 To to IN cord-298240-vcph52gn 18 13 S. S. NNP cord-298240-vcph52gn 18 14 Fung Fung NNP cord-298240-vcph52gn 18 15 and and CC cord-298240-vcph52gn 18 16 Ding Ding NNP cord-298240-vcph52gn 18 17 X. X. NNP cord-298240-vcph52gn 18 18 Liu Liu NNP cord-298240-vcph52gn 18 19 focus focus VB cord-298240-vcph52gn 18 20 on on IN cord-298240-vcph52gn 18 21 coronaviruses coronaviruse NNS cord-298240-vcph52gn 18 22 . . . cord-298240-vcph52gn 19 1 Jim Jim NNP cord-298240-vcph52gn 19 2 - - HYPH cord-298240-vcph52gn 19 3 Tong Tong NNP cord-298240-vcph52gn 19 4 Horng Horng NNP cord-298240-vcph52gn 19 5 's 's POS cord-298240-vcph52gn 19 6 group group NN cord-298240-vcph52gn 19 7 takes take VBZ cord-298240-vcph52gn 19 8 a a DT cord-298240-vcph52gn 19 9 closer close JJR cord-298240-vcph52gn 19 10 look look NN cord-298240-vcph52gn 19 11 at at IN cord-298240-vcph52gn 19 12 virus virus NN cord-298240-vcph52gn 19 13 interaction interaction NN cord-298240-vcph52gn 19 14 with with IN cord-298240-vcph52gn 19 15 autophagy autophagy NN cord-298240-vcph52gn 19 16 and and CC cord-298240-vcph52gn 19 17 also also RB cord-298240-vcph52gn 19 18 discusses discuss VBZ cord-298240-vcph52gn 19 19 the the DT cord-298240-vcph52gn 19 20 potential potential NN cord-298240-vcph52gn 19 21 of of IN cord-298240-vcph52gn 19 22 targeting target VBG cord-298240-vcph52gn 19 23 UPR UPR NNP cord-298240-vcph52gn 19 24 and and CC cord-298240-vcph52gn 19 25 autophagy autophagy NN cord-298240-vcph52gn 19 26 as as IN cord-298240-vcph52gn 19 27 novel novel JJ cord-298240-vcph52gn 19 28 anti anti NNS cord-298240-vcph52gn 19 29 - - NNS cord-298240-vcph52gn 19 30 virals viral NNS cord-298240-vcph52gn 19 31 . . . cord-298240-vcph52gn 20 1 In in IN cord-298240-vcph52gn 20 2 contrast contrast NN cord-298240-vcph52gn 20 3 to to IN cord-298240-vcph52gn 20 4 acute acute JJ cord-298240-vcph52gn 20 5 virus virus NN cord-298240-vcph52gn 20 6 , , , cord-298240-vcph52gn 20 7 one one PRP cord-298240-vcph52gn 20 8 can can MD cord-298240-vcph52gn 20 9 only only RB cord-298240-vcph52gn 20 10 imagine imagine VB cord-298240-vcph52gn 20 11 that that IN cord-298240-vcph52gn 20 12 virus virus NN cord-298240-vcph52gn 20 13 establishing establish VBG cord-298240-vcph52gn 20 14 a a DT cord-298240-vcph52gn 20 15 life life NN cord-298240-vcph52gn 20 16 - - HYPH cord-298240-vcph52gn 20 17 long long JJ cord-298240-vcph52gn 20 18 chronic chronic JJ cord-298240-vcph52gn 20 19 infection infection NN cord-298240-vcph52gn 20 20 may may MD cord-298240-vcph52gn 20 21 interact interact VB cord-298240-vcph52gn 20 22 with with IN cord-298240-vcph52gn 20 23 the the DT cord-298240-vcph52gn 20 24 host host NN cord-298240-vcph52gn 20 25 UPR UPR NNP cord-298240-vcph52gn 20 26 in in IN cord-298240-vcph52gn 20 27 a a DT cord-298240-vcph52gn 20 28 completely completely RB cord-298240-vcph52gn 20 29 different different JJ cord-298240-vcph52gn 20 30 way way NN cord-298240-vcph52gn 20 31 to to TO cord-298240-vcph52gn 20 32 maintain maintain VB cord-298240-vcph52gn 20 33 an an DT cord-298240-vcph52gn 20 34 environment environment NN cord-298240-vcph52gn 20 35 favorable favorable JJ cord-298240-vcph52gn 20 36 for for IN cord-298240-vcph52gn 20 37 virus virus NN cord-298240-vcph52gn 20 38 survival survival NN cord-298240-vcph52gn 20 39 . . . cord-298240-vcph52gn 21 1 Two two CD cord-298240-vcph52gn 21 2 reviews review NNS cord-298240-vcph52gn 21 3 presented present VBN cord-298240-vcph52gn 21 4 by by IN cord-298240-vcph52gn 21 5 Shiu Shiu NNP cord-298240-vcph52gn 21 6 - - HYPH cord-298240-vcph52gn 21 7 Wan Wan NNP cord-298240-vcph52gn 21 8 Chan Chan NNP cord-298240-vcph52gn 21 9 and and CC cord-298240-vcph52gn 21 10 Norica Norica NNP cord-298240-vcph52gn 21 11 Branza Branza NNP cord-298240-vcph52gn 21 12 - - HYPH cord-298240-vcph52gn 21 13 Nichita Nichita NNP cord-298240-vcph52gn 21 14 's 's POS cord-298240-vcph52gn 21 15 group group NN cord-298240-vcph52gn 21 16 on on IN cord-298240-vcph52gn 21 17 hepatitis hepatitis NNP cord-298240-vcph52gn 21 18 C C NNP cord-298240-vcph52gn 21 19 virus virus NN cord-298240-vcph52gn 21 20 and and CC cord-298240-vcph52gn 21 21 hepatitis hepatitis NN cord-298240-vcph52gn 21 22 B B NNP cord-298240-vcph52gn 21 23 virus virus NN cord-298240-vcph52gn 21 24 , , , cord-298240-vcph52gn 21 25 respectively respectively RB cord-298240-vcph52gn 21 26 , , , cord-298240-vcph52gn 21 27 shed shed VBP cord-298240-vcph52gn 21 28 light light NN cord-298240-vcph52gn 21 29 on on IN cord-298240-vcph52gn 21 30 how how WRB cord-298240-vcph52gn 21 31 persistent persistent JJ cord-298240-vcph52gn 21 32 virus virus NN cord-298240-vcph52gn 21 33 interacts interact VBZ cord-298240-vcph52gn 21 34 with with IN cord-298240-vcph52gn 21 35 the the DT cord-298240-vcph52gn 21 36 host host NN cord-298240-vcph52gn 21 37 UPR UPR NNP cord-298240-vcph52gn 21 38 to to TO cord-298240-vcph52gn 21 39 benefit benefit VB cord-298240-vcph52gn 21 40 establishment establishment NN cord-298240-vcph52gn 21 41 of of IN cord-298240-vcph52gn 21 42 a a DT cord-298240-vcph52gn 21 43 chronic chronic JJ cord-298240-vcph52gn 21 44 infection infection NN cord-298240-vcph52gn 21 45 and and CC cord-298240-vcph52gn 21 46 how how WRB cord-298240-vcph52gn 21 47 chronic chronic JJ cord-298240-vcph52gn 21 48 activation activation NN cord-298240-vcph52gn 21 49 of of IN cord-298240-vcph52gn 21 50 the the DT cord-298240-vcph52gn 21 51 UPR UPR NNP cord-298240-vcph52gn 21 52 leads lead VBZ cord-298240-vcph52gn 21 53 to to IN cord-298240-vcph52gn 21 54 diseases disease NNS cord-298240-vcph52gn 21 55 ( ( -LRB- cord-298240-vcph52gn 21 56 Chan Chan NNP cord-298240-vcph52gn 21 57 , , , cord-298240-vcph52gn 21 58 2014 2014 CD cord-298240-vcph52gn 21 59 ; ; : cord-298240-vcph52gn 21 60 Lazar Lazar NNP cord-298240-vcph52gn 21 61 et et NNP cord-298240-vcph52gn 21 62 al al NNP cord-298240-vcph52gn 21 63 . . NNP cord-298240-vcph52gn 21 64 , , , cord-298240-vcph52gn 21 65 2014 2014 CD cord-298240-vcph52gn 21 66 ) ) -RRB- cord-298240-vcph52gn 21 67 . . . cord-298240-vcph52gn 22 1 UPR UPR NNP cord-298240-vcph52gn 22 2 is be VBZ cord-298240-vcph52gn 22 3 prevalent prevalent JJ cord-298240-vcph52gn 22 4 in in IN cord-298240-vcph52gn 22 5 viruses virus NNS cord-298240-vcph52gn 22 6 establishing establish VBG cord-298240-vcph52gn 22 7 latent latent JJ cord-298240-vcph52gn 22 8 infections infection NNS cord-298240-vcph52gn 22 9 such such JJ cord-298240-vcph52gn 22 10 as as IN cord-298240-vcph52gn 22 11 herpesviruses herpesviruses NNP cord-298240-vcph52gn 22 12 . . . cord-298240-vcph52gn 23 1 Herpesvirus Herpesvirus NNP cord-298240-vcph52gn 23 2 is be VBZ cord-298240-vcph52gn 23 3 an an DT cord-298240-vcph52gn 23 4 ancient ancient JJ cord-298240-vcph52gn 23 5 virus virus NN cord-298240-vcph52gn 23 6 . . . cord-298240-vcph52gn 24 1 During during IN cord-298240-vcph52gn 24 2 its -PRON- PRP$ cord-298240-vcph52gn 24 3 course course NN cord-298240-vcph52gn 24 4 of of IN cord-298240-vcph52gn 24 5 millions million NNS cord-298240-vcph52gn 24 6 of of IN cord-298240-vcph52gn 24 7 years year NNS cord-298240-vcph52gn 24 8 of of IN cord-298240-vcph52gn 24 9 co co NN cord-298240-vcph52gn 24 10 - - NN cord-298240-vcph52gn 24 11 inhabitation inhabitation NN cord-298240-vcph52gn 24 12 with with IN cord-298240-vcph52gn 24 13 its -PRON- PRP$ cord-298240-vcph52gn 24 14 host host NN cord-298240-vcph52gn 24 15 , , , cord-298240-vcph52gn 24 16 herpesvirus herpesvirus NN cord-298240-vcph52gn 24 17 has have VBZ cord-298240-vcph52gn 24 18 borrowed borrow VBN cord-298240-vcph52gn 24 19 a a DT cord-298240-vcph52gn 24 20 number number NN cord-298240-vcph52gn 24 21 of of IN cord-298240-vcph52gn 24 22 molecules molecule NNS cord-298240-vcph52gn 24 23 from from IN cord-298240-vcph52gn 24 24 its -PRON- PRP$ cord-298240-vcph52gn 24 25 host host NN cord-298240-vcph52gn 24 26 to to TO cord-298240-vcph52gn 24 27 be be VB cord-298240-vcph52gn 24 28 used use VBN cord-298240-vcph52gn 24 29 in in IN cord-298240-vcph52gn 24 30 its -PRON- PRP$ cord-298240-vcph52gn 24 31 life life NN cord-298240-vcph52gn 24 32 cycle cycle NN cord-298240-vcph52gn 24 33 . . . cord-298240-vcph52gn 25 1 There there EX cord-298240-vcph52gn 25 2 is be VBZ cord-298240-vcph52gn 25 3 no no DT cord-298240-vcph52gn 25 4 exception exception NN cord-298240-vcph52gn 25 5 in in IN cord-298240-vcph52gn 25 6 UPR UPR NNP cord-298240-vcph52gn 25 7 , , , cord-298240-vcph52gn 25 8 in in IN cord-298240-vcph52gn 25 9 which which WDT cord-298240-vcph52gn 25 10 herpesviruses herpesviruses NNP cord-298240-vcph52gn 25 11 also also RB cord-298240-vcph52gn 25 12 share share VBP cord-298240-vcph52gn 25 13 molecular molecular JJ cord-298240-vcph52gn 25 14 mimicry mimicry NN cord-298240-vcph52gn 25 15 with with IN cord-298240-vcph52gn 25 16 the the DT cord-298240-vcph52gn 25 17 UPR UPR NNP cord-298240-vcph52gn 25 18 molecules molecule NNS cord-298240-vcph52gn 25 19 and and CC cord-298240-vcph52gn 25 20 utilize utilize VB cord-298240-vcph52gn 25 21 UPR UPR NNP cord-298240-vcph52gn 25 22 to to TO cord-298240-vcph52gn 25 23 set set VB cord-298240-vcph52gn 25 24 up up RP cord-298240-vcph52gn 25 25 lytic lytic JJ cord-298240-vcph52gn 25 26 infection infection NN cord-298240-vcph52gn 25 27 and and CC cord-298240-vcph52gn 25 28 to to TO cord-298240-vcph52gn 25 29 break break VB cord-298240-vcph52gn 25 30 dormancy dormancy NN cord-298240-vcph52gn 25 31 , , , cord-298240-vcph52gn 25 32 suggesting suggest VBG cord-298240-vcph52gn 25 33 that that IN cord-298240-vcph52gn 25 34 interaction interaction NN cord-298240-vcph52gn 25 35 of of IN cord-298240-vcph52gn 25 36 virus virus NN cord-298240-vcph52gn 25 37 with with IN cord-298240-vcph52gn 25 38 host host NN cord-298240-vcph52gn 25 39 UPR UPR NNP cord-298240-vcph52gn 25 40 may may MD cord-298240-vcph52gn 25 41 be be VB cord-298240-vcph52gn 25 42 very very RB cord-298240-vcph52gn 25 43 ancient ancient JJ cord-298240-vcph52gn 25 44 . . . cord-298240-vcph52gn 26 1 Varicella varicella NN cord-298240-vcph52gn 26 2 - - HYPH cord-298240-vcph52gn 26 3 zoster zoster NN cord-298240-vcph52gn 26 4 virus virus NN cord-298240-vcph52gn 26 5 ( ( -LRB- cord-298240-vcph52gn 26 6 VZV VZV NNP cord-298240-vcph52gn 26 7 ) ) -RRB- cord-298240-vcph52gn 26 8 possesses possess VBZ cord-298240-vcph52gn 26 9 the the DT cord-298240-vcph52gn 26 10 smallest small JJS cord-298240-vcph52gn 26 11 genome genome NN cord-298240-vcph52gn 26 12 of of IN cord-298240-vcph52gn 26 13 human human JJ cord-298240-vcph52gn 26 14 herpesviruses herpesviruse NNS cord-298240-vcph52gn 26 15 and and CC cord-298240-vcph52gn 26 16 lacks lack VBZ cord-298240-vcph52gn 26 17 some some DT cord-298240-vcph52gn 26 18 genes gene NNS cord-298240-vcph52gn 26 19 used use VBN cord-298240-vcph52gn 26 20 by by IN cord-298240-vcph52gn 26 21 other other JJ cord-298240-vcph52gn 26 22 herpesviruses herpesviruse NNS cord-298240-vcph52gn 26 23 to to TO cord-298240-vcph52gn 26 24 manipulate manipulate VB cord-298240-vcph52gn 26 25 the the DT cord-298240-vcph52gn 26 26 UPR UPR NNP cord-298240-vcph52gn 26 27 . . . cord-298240-vcph52gn 27 1 The the DT cord-298240-vcph52gn 27 2 key key JJ cord-298240-vcph52gn 27 3 question question NN cord-298240-vcph52gn 27 4 is be VBZ cord-298240-vcph52gn 27 5 therefore therefore RB cord-298240-vcph52gn 27 6 whether whether IN cord-298240-vcph52gn 27 7 VZV VZV NNP cord-298240-vcph52gn 27 8 UPR UPR NNP cord-298240-vcph52gn 27 9 induction induction NN cord-298240-vcph52gn 27 10 is be VBZ cord-298240-vcph52gn 27 11 merely merely RB cord-298240-vcph52gn 27 12 a a DT cord-298240-vcph52gn 27 13 host host NN cord-298240-vcph52gn 27 14 response response NN cord-298240-vcph52gn 27 15 or or CC cord-298240-vcph52gn 27 16 a a DT cord-298240-vcph52gn 27 17 result result NN cord-298240-vcph52gn 27 18 of of IN cord-298240-vcph52gn 27 19 viral viral JJ cord-298240-vcph52gn 27 20 manipulation manipulation NN cord-298240-vcph52gn 27 21 . . . cord-298240-vcph52gn 28 1 By by IN cord-298240-vcph52gn 28 2 using use VBG cord-298240-vcph52gn 28 3 a a DT cord-298240-vcph52gn 28 4 UPR UPR NNP cord-298240-vcph52gn 28 5 PCR PCR NNP cord-298240-vcph52gn 28 6 array array NN cord-298240-vcph52gn 28 7 , , , cord-298240-vcph52gn 28 8 John John NNP cord-298240-vcph52gn 28 9 Carpenter Carpenter NNP cord-298240-vcph52gn 28 10 and and CC cord-298240-vcph52gn 28 11 Charles Charles NNP cord-298240-vcph52gn 28 12 Grose Grose NNP cord-298240-vcph52gn 28 13 demonstrated demonstrate VBD cord-298240-vcph52gn 28 14 VZV VZV NNP cord-298240-vcph52gn 28 15 differentially differentially RB cord-298240-vcph52gn 28 16 induced induce VBN cord-298240-vcph52gn 28 17 the the DT cord-298240-vcph52gn 28 18 UPR UPR NNP cord-298240-vcph52gn 28 19 to to TO cord-298240-vcph52gn 28 20 expand expand VB cord-298240-vcph52gn 28 21 the the DT cord-298240-vcph52gn 28 22 ER er NN cord-298240-vcph52gn 28 23 to to TO cord-298240-vcph52gn 28 24 cope cope VB cord-298240-vcph52gn 28 25 with with IN cord-298240-vcph52gn 28 26 viral viral JJ cord-298240-vcph52gn 28 27 glycoprotein glycoprotein NN cord-298240-vcph52gn 28 28 synthesis synthesis NN cord-298240-vcph52gn 28 29 ( ( -LRB- cord-298240-vcph52gn 28 30 Carpenter Carpenter NNP cord-298240-vcph52gn 28 31 and and CC cord-298240-vcph52gn 28 32 Grose Grose NNP cord-298240-vcph52gn 28 33 , , , cord-298240-vcph52gn 28 34 2014 2014 CD cord-298240-vcph52gn 28 35 ) ) -RRB- cord-298240-vcph52gn 28 36 . . . cord-298240-vcph52gn 29 1 This this DT cord-298240-vcph52gn 29 2 study study NN cord-298240-vcph52gn 29 3 also also RB cord-298240-vcph52gn 29 4 uncovered uncover VBD cord-298240-vcph52gn 29 5 VZV VZV NNP cord-298240-vcph52gn 29 6 upregulation upregulation NN cord-298240-vcph52gn 29 7 of of IN cord-298240-vcph52gn 29 8 an an DT cord-298240-vcph52gn 29 9 unusual unusual JJ cord-298240-vcph52gn 29 10 UPR UPR NNP cord-298240-vcph52gn 29 11 molecule molecule NN cord-298240-vcph52gn 29 12 , , , cord-298240-vcph52gn 29 13 the the DT cord-298240-vcph52gn 29 14 cAMP camp NN cord-298240-vcph52gn 29 15 responsive responsive JJ cord-298240-vcph52gn 29 16 element element NN cord-298240-vcph52gn 29 17 binding bind VBG cord-298240-vcph52gn 29 18 protein protein NN cord-298240-vcph52gn 30 1 H. H. NNP cord-298240-vcph52gn 30 2 Clearly clearly RB cord-298240-vcph52gn 30 3 , , , cord-298240-vcph52gn 30 4 this this DT cord-298240-vcph52gn 30 5 will will MD cord-298240-vcph52gn 30 6 pave pave VB cord-298240-vcph52gn 30 7 the the DT cord-298240-vcph52gn 30 8 way way NN cord-298240-vcph52gn 30 9 to to IN cord-298240-vcph52gn 30 10 future future JJ cord-298240-vcph52gn 30 11 studies study NNS cord-298240-vcph52gn 30 12 to to TO cord-298240-vcph52gn 30 13 disclose disclose VB cord-298240-vcph52gn 30 14 the the DT cord-298240-vcph52gn 30 15 relationship relationship NN cord-298240-vcph52gn 30 16 between between IN cord-298240-vcph52gn 30 17 VZV VZV NNP cord-298240-vcph52gn 30 18 and and CC cord-298240-vcph52gn 30 19 UPR UPR NNP cord-298240-vcph52gn 30 20 . . . cord-298240-vcph52gn 31 1 ER ER NNP cord-298240-vcph52gn 31 2 - - HYPH cord-298240-vcph52gn 31 3 associated associate VBN cord-298240-vcph52gn 31 4 degradation degradation NN cord-298240-vcph52gn 31 5 ( ( -LRB- cord-298240-vcph52gn 31 6 ERAD ERAD NNP cord-298240-vcph52gn 31 7 ) ) -RRB- cord-298240-vcph52gn 31 8 is be VBZ cord-298240-vcph52gn 31 9 part part NN cord-298240-vcph52gn 31 10 of of IN cord-298240-vcph52gn 31 11 an an DT cord-298240-vcph52gn 31 12 UPR UPR NNP cord-298240-vcph52gn 31 13 functioning function VBG cord-298240-vcph52gn 31 14 to to TO cord-298240-vcph52gn 31 15 extract extract VB cord-298240-vcph52gn 31 16 unfolded unfold VBN cord-298240-vcph52gn 31 17 / / SYM cord-298240-vcph52gn 31 18 misfolded misfolde VBN cord-298240-vcph52gn 31 19 proteins protein NNS cord-298240-vcph52gn 31 20 from from IN cord-298240-vcph52gn 31 21 the the DT cord-298240-vcph52gn 31 22 ER ER NNP cord-298240-vcph52gn 31 23 into into IN cord-298240-vcph52gn 31 24 the the DT cord-298240-vcph52gn 31 25 cytosol cytosol NN cord-298240-vcph52gn 31 26 for for IN cord-298240-vcph52gn 31 27 proteasomal proteasomal JJ cord-298240-vcph52gn 31 28 degradation degradation NN cord-298240-vcph52gn 31 29 . . . cord-298240-vcph52gn 32 1 Not not RB cord-298240-vcph52gn 32 2 surprisingly surprisingly RB cord-298240-vcph52gn 32 3 , , , cord-298240-vcph52gn 32 4 this this DT cord-298240-vcph52gn 32 5 process process NN cord-298240-vcph52gn 32 6 is be VBZ cord-298240-vcph52gn 32 7 also also RB cord-298240-vcph52gn 32 8 targeted target VBN cord-298240-vcph52gn 32 9 by by IN cord-298240-vcph52gn 32 10 virus virus NN cord-298240-vcph52gn 32 11 . . . cord-298240-vcph52gn 33 1 Jaquelin Jaquelin NNP cord-298240-vcph52gn 33 2 Dudley Dudley NNP cord-298240-vcph52gn 33 3 and and CC cord-298240-vcph52gn 33 4 her -PRON- PRP$ cord-298240-vcph52gn 33 5 group group NN cord-298240-vcph52gn 34 1 re re VBG cord-298240-vcph52gn 34 2 - - VBN cord-298240-vcph52gn 34 3 captures capture VBZ cord-298240-vcph52gn 34 4 the the DT cord-298240-vcph52gn 34 5 ERAD ERAD NNP cord-298240-vcph52gn 34 6 process process NN cord-298240-vcph52gn 34 7 in in IN cord-298240-vcph52gn 34 8 details detail NNS cord-298240-vcph52gn 34 9 followed follow VBN cord-298240-vcph52gn 34 10 by by IN cord-298240-vcph52gn 34 11 an an DT cord-298240-vcph52gn 34 12 illustration illustration NN cord-298240-vcph52gn 34 13 of of IN cord-298240-vcph52gn 34 14 how how WRB cord-298240-vcph52gn 34 15 viruses virus NNS cord-298240-vcph52gn 34 16 exploit exploit VBP cord-298240-vcph52gn 34 17 this this DT cord-298240-vcph52gn 34 18 process process NN cord-298240-vcph52gn 34 19 ( ( -LRB- cord-298240-vcph52gn 34 20 Byun Byun NNP cord-298240-vcph52gn 34 21 et et NNP cord-298240-vcph52gn 34 22 al al NNP cord-298240-vcph52gn 34 23 . . NNP cord-298240-vcph52gn 34 24 , , , cord-298240-vcph52gn 34 25 2014 2014 CD cord-298240-vcph52gn 34 26 ) ) -RRB- cord-298240-vcph52gn 34 27 . . . cord-298240-vcph52gn 35 1 First first RB cord-298240-vcph52gn 35 2 , , , cord-298240-vcph52gn 35 3 viruses virus NNS cord-298240-vcph52gn 35 4 can can MD cord-298240-vcph52gn 35 5 simply simply RB cord-298240-vcph52gn 35 6 mobilize mobilize VB cord-298240-vcph52gn 35 7 the the DT cord-298240-vcph52gn 35 8 ERAD ERAD NNP cord-298240-vcph52gn 35 9 to to TO cord-298240-vcph52gn 35 10 degrade degrade VB cord-298240-vcph52gn 35 11 important important JJ cord-298240-vcph52gn 35 12 immune immune JJ cord-298240-vcph52gn 35 13 molecules molecule NNS cord-298240-vcph52gn 35 14 or or CC cord-298240-vcph52gn 35 15 viral viral JJ cord-298240-vcph52gn 35 16 envelope envelope NN cord-298240-vcph52gn 35 17 glycoproteins glycoprotein NNS cord-298240-vcph52gn 35 18 to to TO cord-298240-vcph52gn 35 19 evade evade VB cord-298240-vcph52gn 35 20 innate innate JJ cord-298240-vcph52gn 35 21 and and CC cord-298240-vcph52gn 35 22 adaptive adaptive JJ cord-298240-vcph52gn 35 23 immune immune JJ cord-298240-vcph52gn 35 24 responses response NNS cord-298240-vcph52gn 35 25 . . . cord-298240-vcph52gn 36 1 At at IN cord-298240-vcph52gn 36 2 a a DT cord-298240-vcph52gn 36 3 more more RBR cord-298240-vcph52gn 36 4 intimate intimate JJ cord-298240-vcph52gn 36 5 level level NN cord-298240-vcph52gn 36 6 , , , cord-298240-vcph52gn 36 7 some some DT cord-298240-vcph52gn 36 8 viruses virus NNS cord-298240-vcph52gn 36 9 have have VBP cord-298240-vcph52gn 36 10 actually actually RB cord-298240-vcph52gn 36 11 incorporated incorporate VBN cord-298240-vcph52gn 36 12 ERAD ERAD NNP cord-298240-vcph52gn 36 13 into into IN cord-298240-vcph52gn 36 14 their -PRON- PRP$ cord-298240-vcph52gn 36 15 life life NN cord-298240-vcph52gn 36 16 cycles cycle NNS cord-298240-vcph52gn 36 17 for for IN cord-298240-vcph52gn 36 18 viral viral JJ cord-298240-vcph52gn 36 19 protein protein NN cord-298240-vcph52gn 36 20 and and CC cord-298240-vcph52gn 36 21 even even RB cord-298240-vcph52gn 36 22 virion virion NN cord-298240-vcph52gn 36 23 maturation maturation NN cord-298240-vcph52gn 36 24 . . . cord-298240-vcph52gn 37 1 It -PRON- PRP cord-298240-vcph52gn 37 2 is be VBZ cord-298240-vcph52gn 37 3 fascinating fascinating JJ cord-298240-vcph52gn 37 4 how how WRB cord-298240-vcph52gn 37 5 naked naked JJ cord-298240-vcph52gn 37 6 polyomaviruses polyomaviruse NNS cord-298240-vcph52gn 37 7 will will MD cord-298240-vcph52gn 37 8 make make VB cord-298240-vcph52gn 37 9 a a DT cord-298240-vcph52gn 37 10 de de FW cord-298240-vcph52gn 37 11 tour tour NN cord-298240-vcph52gn 37 12 to to IN cord-298240-vcph52gn 37 13 the the DT cord-298240-vcph52gn 37 14 ER ER NNP cord-298240-vcph52gn 37 15 for for IN cord-298240-vcph52gn 37 16 ERAD ERAD NNP cord-298240-vcph52gn 37 17 - - HYPH cord-298240-vcph52gn 37 18 assisted assist VBN cord-298240-vcph52gn 37 19 uncoating uncoating NN cord-298240-vcph52gn 37 20 before before IN cord-298240-vcph52gn 37 21 re re NN cord-298240-vcph52gn 37 22 - - VBG cord-298240-vcph52gn 37 23 entering enter VBG cord-298240-vcph52gn 37 24 the the DT cord-298240-vcph52gn 37 25 cytosol cytosol NN cord-298240-vcph52gn 37 26 en en IN cord-298240-vcph52gn 37 27 route route NN cord-298240-vcph52gn 37 28 to to IN cord-298240-vcph52gn 37 29 the the DT cord-298240-vcph52gn 37 30 nucleus nucleus NN cord-298240-vcph52gn 37 31 . . . cord-298240-vcph52gn 38 1 Lastly lastly RB cord-298240-vcph52gn 38 2 , , , cord-298240-vcph52gn 38 3 viruses virus NNS cord-298240-vcph52gn 38 4 can can MD cord-298240-vcph52gn 38 5 interfere interfere VB cord-298240-vcph52gn 38 6 with with IN cord-298240-vcph52gn 38 7 ERAD ERAD NNP cord-298240-vcph52gn 38 8 tuning tuning NN cord-298240-vcph52gn 38 9 and and CC cord-298240-vcph52gn 38 10 hijack hijack VB cord-298240-vcph52gn 38 11 certain certain JJ cord-298240-vcph52gn 38 12 ERAD ERAD NNP cord-298240-vcph52gn 38 13 cargo cargo NN cord-298240-vcph52gn 38 14 into into IN cord-298240-vcph52gn 38 15 forming form VBG cord-298240-vcph52gn 38 16 double double JJ cord-298240-vcph52gn 38 17 membrane membrane NN cord-298240-vcph52gn 38 18 vesicles vesicle NNS cord-298240-vcph52gn 38 19 as as IN cord-298240-vcph52gn 38 20 sites site NNS cord-298240-vcph52gn 38 21 of of IN cord-298240-vcph52gn 38 22 virus virus NN cord-298240-vcph52gn 38 23 replication replication NN cord-298240-vcph52gn 38 24 . . . cord-298240-vcph52gn 39 1 UPR UPR NNP cord-298240-vcph52gn 39 2 has have VBZ cord-298240-vcph52gn 39 3 emerged emerge VBN cord-298240-vcph52gn 39 4 to to TO cord-298240-vcph52gn 39 5 be be VB cord-298240-vcph52gn 39 6 more more JJR cord-298240-vcph52gn 39 7 than than IN cord-298240-vcph52gn 39 8 a a DT cord-298240-vcph52gn 39 9 homeostatic homeostatic JJ cord-298240-vcph52gn 39 10 cellular cellular JJ cord-298240-vcph52gn 39 11 response response NN cord-298240-vcph52gn 39 12 to to IN cord-298240-vcph52gn 39 13 virus virus NN cord-298240-vcph52gn 39 14 infections infection NNS cord-298240-vcph52gn 39 15 . . . cord-298240-vcph52gn 40 1 UPR UPR NNP cord-298240-vcph52gn 40 2 has have VBZ cord-298240-vcph52gn 40 3 been be VBN cord-298240-vcph52gn 40 4 intimately intimately RB cord-298240-vcph52gn 40 5 linked link VBN cord-298240-vcph52gn 40 6 to to IN cord-298240-vcph52gn 40 7 innate innate JJ cord-298240-vcph52gn 40 8 immunity immunity NN cord-298240-vcph52gn 40 9 ; ; : cord-298240-vcph52gn 40 10 whether whether IN cord-298240-vcph52gn 40 11 by by IN cord-298240-vcph52gn 40 12 modulating modulate VBG cord-298240-vcph52gn 40 13 innate innate JJ cord-298240-vcph52gn 40 14 immunity immunity NN cord-298240-vcph52gn 40 15 or or CC cord-298240-vcph52gn 40 16 as as IN cord-298240-vcph52gn 40 17 part part NN cord-298240-vcph52gn 40 18 of of IN cord-298240-vcph52gn 40 19 the the DT cord-298240-vcph52gn 40 20 innate innate JJ cord-298240-vcph52gn 40 21 immunity immunity NN cord-298240-vcph52gn 40 22 . . . cord-298240-vcph52gn 41 1 Innate innate JJ cord-298240-vcph52gn 41 2 immunity immunity NN cord-298240-vcph52gn 41 3 is be VBZ cord-298240-vcph52gn 41 4 initiated initiate VBN cord-298240-vcph52gn 41 5 by by IN cord-298240-vcph52gn 41 6 the the DT cord-298240-vcph52gn 41 7 sensing sensing NN cord-298240-vcph52gn 41 8 of of IN cord-298240-vcph52gn 41 9 " " `` cord-298240-vcph52gn 41 10 danger danger NN cord-298240-vcph52gn 41 11 signals signal NNS cord-298240-vcph52gn 41 12 " " '' cord-298240-vcph52gn 41 13 by by IN cord-298240-vcph52gn 41 14 host host NN cord-298240-vcph52gn 41 15 pattern pattern NN cord-298240-vcph52gn 41 16 recognition recognition NN cord-298240-vcph52gn 41 17 receptors receptor NNS cord-298240-vcph52gn 41 18 ( ( -LRB- cord-298240-vcph52gn 41 19 PRRs PRRs NNP cord-298240-vcph52gn 41 20 ) ) -RRB- cord-298240-vcph52gn 41 21 , , , cord-298240-vcph52gn 41 22 culminating culminate VBG cord-298240-vcph52gn 41 23 in in IN cord-298240-vcph52gn 41 24 the the DT cord-298240-vcph52gn 41 25 release release NN cord-298240-vcph52gn 41 26 of of IN cord-298240-vcph52gn 41 27 interferon interferon NN cord-298240-vcph52gn 41 28 , , , cord-298240-vcph52gn 41 29 which which WDT cord-298240-vcph52gn 41 30 in in IN cord-298240-vcph52gn 41 31 turn turn NN cord-298240-vcph52gn 41 32 activates activate VBZ cord-298240-vcph52gn 41 33 the the DT cord-298240-vcph52gn 41 34 professional professional JJ cord-298240-vcph52gn 41 35 virus virus NN cord-298240-vcph52gn 41 36 killer killer NN cord-298240-vcph52gn 41 37 , , , cord-298240-vcph52gn 41 38 one one CD cord-298240-vcph52gn 41 39 of of IN cord-298240-vcph52gn 41 40 which which WDT cord-298240-vcph52gn 41 41 is be VBZ cord-298240-vcph52gn 41 42 RNase RNase NNP cord-298240-vcph52gn 41 43 L. L. NNP cord-298240-vcph52gn 41 44 One one CD cord-298240-vcph52gn 41 45 of of IN cord-298240-vcph52gn 41 46 the the DT cord-298240-vcph52gn 41 47 proximal proximal JJ cord-298240-vcph52gn 41 48 UPR UPR NNP cord-298240-vcph52gn 41 49 sensors sensor NNS cord-298240-vcph52gn 41 50 , , , cord-298240-vcph52gn 41 51 inositol inositol NN cord-298240-vcph52gn 41 52 - - HYPH cord-298240-vcph52gn 41 53 requiring require VBG cord-298240-vcph52gn 41 54 enzyme enzyme NN cord-298240-vcph52gn 41 55 1 1 CD cord-298240-vcph52gn 41 56 ( ( -LRB- cord-298240-vcph52gn 41 57 IRE1 IRE1 NNP cord-298240-vcph52gn 41 58 ) ) -RRB- cord-298240-vcph52gn 41 59 , , , cord-298240-vcph52gn 41 60 is be VBZ cord-298240-vcph52gn 41 61 evolutionarily evolutionarily RB cord-298240-vcph52gn 41 62 related related JJ cord-298240-vcph52gn 41 63 to to IN cord-298240-vcph52gn 41 64 RNase RNase NNP cord-298240-vcph52gn 41 65 L. L. NNP cord-298240-vcph52gn 42 1 In in IN cord-298240-vcph52gn 42 2 the the DT cord-298240-vcph52gn 42 3 review review NN cord-298240-vcph52gn 42 4 of of IN cord-298240-vcph52gn 42 5 Sankar Sankar NNP cord-298240-vcph52gn 42 6 Bhattacharyya Bhattacharyya NNP cord-298240-vcph52gn 42 7 , , , cord-298240-vcph52gn 42 8 he -PRON- PRP cord-298240-vcph52gn 42 9 provides provide VBZ cord-298240-vcph52gn 42 10 a a DT cord-298240-vcph52gn 42 11 structural structural JJ cord-298240-vcph52gn 42 12 and and CC cord-298240-vcph52gn 42 13 functional functional JJ cord-298240-vcph52gn 42 14 comparison comparison NN cord-298240-vcph52gn 42 15 between between IN cord-298240-vcph52gn 42 16 IRE1 IRE1 NNP cord-298240-vcph52gn 42 17 and and CC cord-298240-vcph52gn 42 18 RNase RNase NNP cord-298240-vcph52gn 42 19 L L NNP cord-298240-vcph52gn 42 20 and and CC cord-298240-vcph52gn 42 21 comments comment NNS cord-298240-vcph52gn 42 22 on on IN cord-298240-vcph52gn 42 23 a a DT cord-298240-vcph52gn 42 24 potential potential JJ cord-298240-vcph52gn 42 25 anti anti JJ cord-298240-vcph52gn 42 26 - - JJ cord-298240-vcph52gn 42 27 viral viral JJ cord-298240-vcph52gn 42 28 function function NN cord-298240-vcph52gn 42 29 of of IN cord-298240-vcph52gn 42 30 IRE1 IRE1 NNP cord-298240-vcph52gn 42 31 by by IN cord-298240-vcph52gn 42 32 the the DT cord-298240-vcph52gn 42 33 creation creation NN cord-298240-vcph52gn 42 34 of of IN cord-298240-vcph52gn 42 35 " " `` cord-298240-vcph52gn 42 36 danger danger NN cord-298240-vcph52gn 42 37 signals signal NNS cord-298240-vcph52gn 42 38 " " '' cord-298240-vcph52gn 42 39 via via IN cord-298240-vcph52gn 42 40 the the DT cord-298240-vcph52gn 42 41 regulated regulated JJ cord-298240-vcph52gn 42 42 IRE1-dependent ire1-dependent NN cord-298240-vcph52gn 42 43 decay decay NN cord-298240-vcph52gn 42 44 ( ( -LRB- cord-298240-vcph52gn 42 45 RIDD RIDD NNP cord-298240-vcph52gn 42 46 ) ) -RRB- cord-298240-vcph52gn 42 47 pathway pathway NN cord-298240-vcph52gn 42 48 ( ( -LRB- cord-298240-vcph52gn 42 49 Bhattacharyya Bhattacharyya NNP cord-298240-vcph52gn 42 50 , , , cord-298240-vcph52gn 42 51 2014 2014 CD cord-298240-vcph52gn 42 52 ) ) -RRB- cord-298240-vcph52gn 42 53 . . . cord-298240-vcph52gn 43 1 An an DT cord-298240-vcph52gn 43 2 important important JJ cord-298240-vcph52gn 43 3 question question NN cord-298240-vcph52gn 43 4 remains remain VBZ cord-298240-vcph52gn 43 5 as as IN cord-298240-vcph52gn 43 6 to to IN cord-298240-vcph52gn 43 7 whether whether IN cord-298240-vcph52gn 43 8 UPR UPR NNP cord-298240-vcph52gn 43 9 represents represent VBZ cord-298240-vcph52gn 43 10 a a DT cord-298240-vcph52gn 43 11 new new JJ cord-298240-vcph52gn 43 12 tool tool NN cord-298240-vcph52gn 43 13 for for IN cord-298240-vcph52gn 43 14 sensing sense VBG cord-298240-vcph52gn 43 15 viruses virus NNS cord-298240-vcph52gn 43 16 or or CC cord-298240-vcph52gn 43 17 select select VB cord-298240-vcph52gn 43 18 UPR UPR NNP cord-298240-vcph52gn 43 19 molecules molecule NNS cord-298240-vcph52gn 43 20 are be VBP cord-298240-vcph52gn 43 21 merely merely RB cord-298240-vcph52gn 43 22 being be VBG cord-298240-vcph52gn 43 23 co co VBN cord-298240-vcph52gn 43 24 - - VBN cord-298240-vcph52gn 43 25 opted opt VBN cord-298240-vcph52gn 43 26 in in IN cord-298240-vcph52gn 43 27 " " `` cord-298240-vcph52gn 43 28 microbial microbial JJ cord-298240-vcph52gn 43 29 stress stress NN cord-298240-vcph52gn 43 30 response response NN cord-298240-vcph52gn 43 31 . . . cord-298240-vcph52gn 44 1 " " `` cord-298240-vcph52gn 44 2 This this DT cord-298240-vcph52gn 44 3 is be VBZ cord-298240-vcph52gn 44 4 being be VBG cord-298240-vcph52gn 44 5 addressed address VBN cord-298240-vcph52gn 44 6 in in IN cord-298240-vcph52gn 44 7 Judith Judith NNP cord-298240-vcph52gn 44 8 Smith Smith NNP cord-298240-vcph52gn 44 9 's 's POS cord-298240-vcph52gn 44 10 review review NN cord-298240-vcph52gn 44 11 , , , cord-298240-vcph52gn 44 12 in in IN cord-298240-vcph52gn 44 13 which which WDT cord-298240-vcph52gn 44 14 she -PRON- PRP cord-298240-vcph52gn 44 15 provides provide VBZ cord-298240-vcph52gn 44 16 a a DT cord-298240-vcph52gn 44 17 critique critique NN cord-298240-vcph52gn 44 18 on on IN cord-298240-vcph52gn 44 19 the the DT cord-298240-vcph52gn 44 20 intersection intersection NN cord-298240-vcph52gn 44 21 of of IN cord-298240-vcph52gn 44 22 the the DT cord-298240-vcph52gn 44 23 UPR UPR NNP cord-298240-vcph52gn 44 24 with with IN cord-298240-vcph52gn 44 25 the the DT cord-298240-vcph52gn 44 26 inflammatory inflammatory JJ cord-298240-vcph52gn 44 27 pathways pathway NNS cord-298240-vcph52gn 44 28 and and CC cord-298240-vcph52gn 44 29 innate innate JJ cord-298240-vcph52gn 44 30 immunity immunity NN cord-298240-vcph52gn 44 31 and and CC cord-298240-vcph52gn 44 32 offers offer VBZ cord-298240-vcph52gn 44 33 an an DT cord-298240-vcph52gn 44 34 insight insight NN cord-298240-vcph52gn 44 35 into into IN cord-298240-vcph52gn 44 36 UPR UPR NNP cord-298240-vcph52gn 44 37 - - HYPH cord-298240-vcph52gn 44 38 PRR PRR NNP cord-298240-vcph52gn 44 39 synergy synergy NN cord-298240-vcph52gn 44 40 as as IN cord-298240-vcph52gn 44 41 an an DT cord-298240-vcph52gn 44 42 evolutionary evolutionary JJ cord-298240-vcph52gn 44 43 adaptation adaptation NN cord-298240-vcph52gn 44 44 to to TO cord-298240-vcph52gn 44 45 ensure ensure VB cord-298240-vcph52gn 44 46 specificity specificity NN cord-298240-vcph52gn 44 47 of of IN cord-298240-vcph52gn 44 48 anti anti JJ cord-298240-vcph52gn 44 49 - - JJ cord-298240-vcph52gn 44 50 viral viral JJ cord-298240-vcph52gn 44 51 responses response NNS cord-298240-vcph52gn 44 52 ( ( -LRB- cord-298240-vcph52gn 44 53 Smith Smith NNP cord-298240-vcph52gn 44 54 , , , cord-298240-vcph52gn 44 55 2014 2014 CD cord-298240-vcph52gn 44 56 ) ) -RRB- cord-298240-vcph52gn 44 57 . . . cord-298240-vcph52gn 45 1 It -PRON- PRP cord-298240-vcph52gn 45 2 is be VBZ cord-298240-vcph52gn 45 3 increasingly increasingly RB cord-298240-vcph52gn 45 4 popular popular JJ cord-298240-vcph52gn 45 5 to to TO cord-298240-vcph52gn 45 6 use use VB cord-298240-vcph52gn 45 7 viruses virus NNS cord-298240-vcph52gn 45 8 in in IN cord-298240-vcph52gn 45 9 clinical clinical JJ cord-298240-vcph52gn 45 10 applications application NNS cord-298240-vcph52gn 45 11 such such JJ cord-298240-vcph52gn 45 12 as as IN cord-298240-vcph52gn 45 13 gene gene NN cord-298240-vcph52gn 45 14 therapy therapy NN cord-298240-vcph52gn 45 15 and and CC cord-298240-vcph52gn 45 16 oncolytic oncolytic JJ cord-298240-vcph52gn 45 17 virotherapy virotherapy NN cord-298240-vcph52gn 45 18 . . . cord-298240-vcph52gn 46 1 The the DT cord-298240-vcph52gn 46 2 use use NN cord-298240-vcph52gn 46 3 of of IN cord-298240-vcph52gn 46 4 viral viral JJ cord-298240-vcph52gn 46 5 vectors vector NNS cord-298240-vcph52gn 46 6 / / SYM cord-298240-vcph52gn 46 7 viruses virus NNS cord-298240-vcph52gn 46 8 in in IN cord-298240-vcph52gn 46 9 the the DT cord-298240-vcph52gn 46 10 clinics clinic NNS cord-298240-vcph52gn 46 11 will will MD cord-298240-vcph52gn 46 12 not not RB cord-298240-vcph52gn 46 13 be be VB cord-298240-vcph52gn 46 14 valid valid JJ cord-298240-vcph52gn 46 15 without without IN cord-298240-vcph52gn 46 16 a a DT cord-298240-vcph52gn 46 17 thorough thorough JJ cord-298240-vcph52gn 46 18 understanding understanding NN cord-298240-vcph52gn 46 19 of of IN cord-298240-vcph52gn 46 20 virus virus NN cord-298240-vcph52gn 46 21 - - HYPH cord-298240-vcph52gn 46 22 host host NN cord-298240-vcph52gn 46 23 interaction interaction NN cord-298240-vcph52gn 46 24 . . . cord-298240-vcph52gn 47 1 Giridhara Giridhara NNP cord-298240-vcph52gn 47 2 Jayandharan Jayandharan NNP cord-298240-vcph52gn 47 3 and and CC cord-298240-vcph52gn 47 4 his -PRON- PRP$ cord-298240-vcph52gn 47 5 group group NN cord-298240-vcph52gn 47 6 presents present VBZ cord-298240-vcph52gn 47 7 a a DT cord-298240-vcph52gn 47 8 review review NN cord-298240-vcph52gn 47 9 on on IN cord-298240-vcph52gn 47 10 the the DT cord-298240-vcph52gn 47 11 emerging emerge VBG cord-298240-vcph52gn 47 12 impact impact NN cord-298240-vcph52gn 47 13 of of IN cord-298240-vcph52gn 47 14 UPR UPR NNP cord-298240-vcph52gn 47 15 on on IN cord-298240-vcph52gn 47 16 gene gene NN cord-298240-vcph52gn 47 17 therapy therapy NN cord-298240-vcph52gn 47 18 and and CC cord-298240-vcph52gn 47 19 how how WRB cord-298240-vcph52gn 47 20 the the DT cord-298240-vcph52gn 47 21 understanding understanding NN cord-298240-vcph52gn 47 22 of of IN cord-298240-vcph52gn 47 23 this this DT cord-298240-vcph52gn 47 24 will will MD cord-298240-vcph52gn 47 25 allow allow VB cord-298240-vcph52gn 47 26 us -PRON- PRP cord-298240-vcph52gn 47 27 to to TO cord-298240-vcph52gn 47 28 exploit exploit VB cord-298240-vcph52gn 47 29 and and CC cord-298240-vcph52gn 47 30 improve improve VB cord-298240-vcph52gn 47 31 the the DT cord-298240-vcph52gn 47 32 use use NN cord-298240-vcph52gn 47 33 of of IN cord-298240-vcph52gn 47 34 viral viral JJ cord-298240-vcph52gn 47 35 vectors vector NNS cord-298240-vcph52gn 47 36 in in IN cord-298240-vcph52gn 47 37 gene gene NN cord-298240-vcph52gn 47 38 therapy therapy NN cord-298240-vcph52gn 47 39 ( ( -LRB- cord-298240-vcph52gn 47 40 Sen Sen NNP cord-298240-vcph52gn 47 41 et et NNP cord-298240-vcph52gn 47 42 al al NNP cord-298240-vcph52gn 47 43 . . NNP cord-298240-vcph52gn 47 44 , , , cord-298240-vcph52gn 47 45 2014 2014 CD cord-298240-vcph52gn 47 46 ) ) -RRB- cord-298240-vcph52gn 47 47 . . . cord-298240-vcph52gn 48 1 To to IN cord-298240-vcph52gn 48 2 date date NN cord-298240-vcph52gn 48 3 we -PRON- PRP cord-298240-vcph52gn 48 4 are be VBP cord-298240-vcph52gn 48 5 still still RB cord-298240-vcph52gn 48 6 at at IN cord-298240-vcph52gn 48 7 the the DT cord-298240-vcph52gn 48 8 sprouting sprouting JJ cord-298240-vcph52gn 48 9 stage stage NN cord-298240-vcph52gn 48 10 of of IN cord-298240-vcph52gn 48 11 understanding understand VBG cord-298240-vcph52gn 48 12 this this DT cord-298240-vcph52gn 48 13 virus virus NN cord-298240-vcph52gn 48 14 - - HYPH cord-298240-vcph52gn 48 15 host host NN cord-298240-vcph52gn 48 16 interaction interaction NN cord-298240-vcph52gn 48 17 . . . cord-298240-vcph52gn 49 1 We -PRON- PRP cord-298240-vcph52gn 49 2 hope hope VBP cord-298240-vcph52gn 49 3 that that IN cord-298240-vcph52gn 49 4 this this DT cord-298240-vcph52gn 49 5 selection selection NN cord-298240-vcph52gn 49 6 of of IN cord-298240-vcph52gn 49 7 articles article NNS cord-298240-vcph52gn 49 8 will will MD cord-298240-vcph52gn 49 9 provide provide VB cord-298240-vcph52gn 49 10 a a DT cord-298240-vcph52gn 49 11 foundation foundation NN cord-298240-vcph52gn 49 12 to to TO cord-298240-vcph52gn 49 13 spark spark VB cord-298240-vcph52gn 49 14 more more JJR cord-298240-vcph52gn 49 15 interest interest NN cord-298240-vcph52gn 49 16 in in IN cord-298240-vcph52gn 49 17 this this DT cord-298240-vcph52gn 49 18 research research NN cord-298240-vcph52gn 49 19 area area NN cord-298240-vcph52gn 49 20 . . . cord-298240-vcph52gn 50 1 This this DT cord-298240-vcph52gn 50 2 will will MD cord-298240-vcph52gn 50 3 not not RB cord-298240-vcph52gn 50 4 only only RB cord-298240-vcph52gn 50 5 lead lead VB cord-298240-vcph52gn 50 6 to to IN cord-298240-vcph52gn 50 7 a a DT cord-298240-vcph52gn 50 8 deeper deep JJR cord-298240-vcph52gn 50 9 understanding understanding NN cord-298240-vcph52gn 50 10 of of IN cord-298240-vcph52gn 50 11 virus virus NN cord-298240-vcph52gn 50 12 infection infection NN cord-298240-vcph52gn 50 13 and and CC cord-298240-vcph52gn 50 14 pathogenesis pathogenesis NN cord-298240-vcph52gn 50 15 but but CC cord-298240-vcph52gn 50 16 will will MD cord-298240-vcph52gn 50 17 also also RB cord-298240-vcph52gn 50 18 unravel unravel VB cord-298240-vcph52gn 50 19 novel novel JJ cord-298240-vcph52gn 50 20 anti anti JJ cord-298240-vcph52gn 50 21 - - JJ cord-298240-vcph52gn 50 22 viral viral JJ cord-298240-vcph52gn 50 23 mechanisms mechanism NNS cord-298240-vcph52gn 50 24 . . . cord-298240-vcph52gn 51 1 Eventually eventually RB cord-298240-vcph52gn 51 2 it -PRON- PRP cord-298240-vcph52gn 51 3 will will MD cord-298240-vcph52gn 51 4 help help VB cord-298240-vcph52gn 51 5 to to TO cord-298240-vcph52gn 51 6 unlock unlock VB cord-298240-vcph52gn 51 7 novel novel JJ cord-298240-vcph52gn 51 8 anti anti JJ cord-298240-vcph52gn 51 9 - - JJ cord-298240-vcph52gn 51 10 viral viral JJ cord-298240-vcph52gn 51 11 targets target NNS cord-298240-vcph52gn 51 12 and and CC cord-298240-vcph52gn 51 13 may may MD cord-298240-vcph52gn 51 14 also also RB cord-298240-vcph52gn 51 15 impact impact VB cord-298240-vcph52gn 51 16 on on IN cord-298240-vcph52gn 51 17 optimizing optimize VBG cord-298240-vcph52gn 51 18 the the DT cord-298240-vcph52gn 51 19 use use NN cord-298240-vcph52gn 51 20 of of IN cord-298240-vcph52gn 51 21 viruses virus NNS cord-298240-vcph52gn 51 22 in in IN cord-298240-vcph52gn 51 23 the the DT cord-298240-vcph52gn 51 24 clinics clinic NNS cord-298240-vcph52gn 51 25 . . . cord-298240-vcph52gn 52 1 Ca can MD cord-298240-vcph52gn 52 2 n't not RB cord-298240-vcph52gn 52 3 RIDD ridd VB cord-298240-vcph52gn 52 4 off off RP cord-298240-vcph52gn 52 5 viruses virus NNS cord-298240-vcph52gn 53 1 Stress stress NN cord-298240-vcph52gn 53 2 responses response NNS cord-298240-vcph52gn 53 3 in in IN cord-298240-vcph52gn 53 4 flavivirus flavivirus JJ cord-298240-vcph52gn 53 5 - - HYPH cord-298240-vcph52gn 53 6 infected infect VBN cord-298240-vcph52gn 53 7 cells cell NNS cord-298240-vcph52gn 53 8 : : : cord-298240-vcph52gn 53 9 activation activation NN cord-298240-vcph52gn 53 10 of of IN cord-298240-vcph52gn 53 11 unfolded unfolded JJ cord-298240-vcph52gn 53 12 protein protein NN cord-298240-vcph52gn 53 13 response response NN cord-298240-vcph52gn 53 14 and and CC cord-298240-vcph52gn 53 15 autophagy autophagy VB cord-298240-vcph52gn 53 16 ERAD ERAD NNP cord-298240-vcph52gn 53 17 and and CC cord-298240-vcph52gn 53 18 how how WRB cord-298240-vcph52gn 53 19 viruses virus NNS cord-298240-vcph52gn 53 20 exploit exploit VBP cord-298240-vcph52gn 53 21 it -PRON- PRP cord-298240-vcph52gn 53 22 Varicella varicella NN cord-298240-vcph52gn 53 23 - - HYPH cord-298240-vcph52gn 53 24 zoster zoster NN cord-298240-vcph52gn 53 25 virus virus NN cord-298240-vcph52gn 53 26 glycoprotein glycoprotein NN cord-298240-vcph52gn 53 27 expression expression NN cord-298240-vcph52gn 53 28 differentially differentially RB cord-298240-vcph52gn 53 29 induces induce VBZ cord-298240-vcph52gn 53 30 the the DT cord-298240-vcph52gn 53 31 unfolded unfolded JJ cord-298240-vcph52gn 53 32 protein protein NN cord-298240-vcph52gn 53 33 response response NN cord-298240-vcph52gn 53 34 in in IN cord-298240-vcph52gn 53 35 infected infected JJ cord-298240-vcph52gn 53 36 cells cell NNS cord-298240-vcph52gn 53 37 Unfolded unfold VBD cord-298240-vcph52gn 53 38 protein protein NN cord-298240-vcph52gn 53 39 response response NN cord-298240-vcph52gn 53 40 in in IN cord-298240-vcph52gn 53 41 hepatitis hepatitis NN cord-298240-vcph52gn 53 42 C C NNP cord-298240-vcph52gn 53 43 virus virus NN cord-298240-vcph52gn 53 44 infection infection NN cord-298240-vcph52gn 53 45 Coronavirus Coronavirus NNP cord-298240-vcph52gn 53 46 infection infection NN cord-298240-vcph52gn 53 47 , , , cord-298240-vcph52gn 53 48 ER ER NNP cord-298240-vcph52gn 53 49 stress stress NN cord-298240-vcph52gn 53 50 , , , cord-298240-vcph52gn 53 51 apoptosis apoptosis NN cord-298240-vcph52gn 53 52 and and CC cord-298240-vcph52gn 53 53 innate innate JJ cord-298240-vcph52gn 53 54 immunity immunity NN cord-298240-vcph52gn 53 55 ER er NN cord-298240-vcph52gn 53 56 stress stress NN cord-298240-vcph52gn 53 57 , , , cord-298240-vcph52gn 53 58 autophagy autophagy NN cord-298240-vcph52gn 53 59 , , , cord-298240-vcph52gn 53 60 and and CC cord-298240-vcph52gn 53 61 RNA RNA NNP cord-298240-vcph52gn 53 62 viruses virus NNS cord-298240-vcph52gn 54 1 Modulation modulation NN cord-298240-vcph52gn 54 2 of of IN cord-298240-vcph52gn 54 3 the the DT cord-298240-vcph52gn 54 4 unfolded unfolded JJ cord-298240-vcph52gn 54 5 protein protein NN cord-298240-vcph52gn 54 6 response response NN cord-298240-vcph52gn 54 7 by by IN cord-298240-vcph52gn 54 8 the the DT cord-298240-vcph52gn 54 9 human human JJ cord-298240-vcph52gn 54 10 hepatitis hepatitis NN cord-298240-vcph52gn 54 11 B B NNP cord-298240-vcph52gn 54 12 virus virus NN cord-298240-vcph52gn 54 13 Cellular Cellular NNP cord-298240-vcph52gn 54 14 unfolded unfold VBD cord-298240-vcph52gn 54 15 protein protein NN cord-298240-vcph52gn 54 16 response response NN cord-298240-vcph52gn 54 17 against against IN cord-298240-vcph52gn 54 18 viruses virus NNS cord-298240-vcph52gn 54 19 used use VBN cord-298240-vcph52gn 54 20 in in IN cord-298240-vcph52gn 54 21 gene gene NN cord-298240-vcph52gn 54 22 therapy therapy NN cord-298240-vcph52gn 55 1 A a DT cord-298240-vcph52gn 55 2 new new JJ cord-298240-vcph52gn 55 3 paradigm paradigm NN cord-298240-vcph52gn 55 4 : : : cord-298240-vcph52gn 55 5 innate innate JJ cord-298240-vcph52gn 55 6 immune immune JJ cord-298240-vcph52gn 55 7 sensing sensing NN cord-298240-vcph52gn 55 8 of of IN cord-298240-vcph52gn 55 9 viruses virus NNS cord-298240-vcph52gn 55 10 via via IN cord-298240-vcph52gn 55 11 the the DT cord-298240-vcph52gn 55 12 unfolded unfolded JJ cord-298240-vcph52gn 55 13 protein protein NN cord-298240-vcph52gn 55 14 response response NN cord-298240-vcph52gn 55 15 Conflict conflict NN cord-298240-vcph52gn 55 16 of of IN cord-298240-vcph52gn 55 17 Interest Interest NNP cord-298240-vcph52gn 55 18 Statement Statement NNP cord-298240-vcph52gn 55 19 : : : cord-298240-vcph52gn 56 1 The the DT cord-298240-vcph52gn 56 2 author author NN cord-298240-vcph52gn 56 3 declares declare VBZ cord-298240-vcph52gn 56 4 that that IN cord-298240-vcph52gn 56 5 the the DT cord-298240-vcph52gn 56 6 research research NN cord-298240-vcph52gn 56 7 was be VBD cord-298240-vcph52gn 56 8 conducted conduct VBN cord-298240-vcph52gn 56 9 in in IN cord-298240-vcph52gn 56 10 the the DT cord-298240-vcph52gn 56 11 absence absence NN cord-298240-vcph52gn 56 12 of of IN cord-298240-vcph52gn 56 13 any any DT cord-298240-vcph52gn 56 14 commercial commercial JJ cord-298240-vcph52gn 56 15 or or CC cord-298240-vcph52gn 56 16 financial financial JJ cord-298240-vcph52gn 56 17 relationships relationship NNS cord-298240-vcph52gn 56 18 that that WDT cord-298240-vcph52gn 56 19 could could MD cord-298240-vcph52gn 56 20 be be VB cord-298240-vcph52gn 56 21 construed construe VBN cord-298240-vcph52gn 56 22 as as IN cord-298240-vcph52gn 56 23 a a DT cord-298240-vcph52gn 56 24 potential potential JJ cord-298240-vcph52gn 56 25 conflict conflict NN cord-298240-vcph52gn 56 26 of of IN cord-298240-vcph52gn 56 27 interest interest NN