id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-331503-whw2pq1f	Torres, Orlando A.	Role of the IFNG +874T/A polymorphism in Chagas disease in a Colombian population	2010-03-30		.txt	text/plain	3092	159	43	The human IFNG IFN-g Chagas disease Single nucleotide polymorphism (SNP) Genetics Association study A B S T R A C T Genetic susceptibility to Trypanosoma cruzi infection and the development of cardiomyopathy is complex, heterogeneous, and likely involves several genes. Here we investigated the association between the interferon-gamma gene (IFNG) +874T/A polymorphism and Chagas disease, focusing on susceptibility and severity. Here we investigated the association between the interferon-gamma gene (IFNG) +874T/A polymorphism and Chagas disease, focusing on susceptibility and severity. Due to this, we selected the +874T/A polymorphism of IFNG to assess the potential association of this SNP in the susceptibility and/or clinical features of Chagas disease in a Colombian population from an endemic area. We found a statistically significant difference in the distribution of the A/A genotype (low production of IFN-g) and the A allele at the IFNG polymorphism between Chagas patient and control groups.	./cache/cord-331503-whw2pq1f.txt	./txt/cord-331503-whw2pq1f.txt