id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-338723-3vm23fgy	Lee, In-Hee	A survey of genetic variants in SARS-CoV-2 interacting domains of ACE2, TMPRSS2 and TLR3/7/8 across populations	2020-08-26		.txt	text/plain	2784	183	57	title: A survey of genetic variants in SARS-CoV-2 interacting domains of ACE2, TMPRSS2 and TLR3/7/8 across populations Nonetheless, a systematic mutagenesis study on the receptor binding domain of ACE2 is required to understand the difference in host-viral interaction across populations. SARS-CoV-2 is an enveloped and positive single-stranded RNA (ssRNA) virus and initiates human cell entry by binding of spike (S) protein present on the viral envelope to angiotensin converting enzyme 2 (ACE2) receptor on the host cells (Zhou et al., 2020b) . Here we surveyed the genetic variants in functional residues of ACE2, TMPRSS2, CTSB/L (CatB/L), and TLR3/7/8 to investigate the difference in the genetic predisposition to the susceptibly of SARS-CoV-2 infection and the initiation of innate immune response. The list of reported genetic variants in the genes and their allele frequencies (AFs) were ACE2 is highly conserved with few nonsynonymous variants in the interacting domain with the SARS-CoV-2 RBM (Lan et al., 2020) .	./cache/cord-338723-3vm23fgy.txt	./txt/cord-338723-3vm23fgy.txt