id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-011536-rb8g5llp	Jiang, Dong	Could Environment Affect the Mutation of H1N1 Influenza Virus?	2020-04-29		.txt	text/plain	3762	188	43	According to the research of Aitor Nogales et al., the H3N2 virus encoding the NS1-V194I protein displays a temperature-sensitive phenotype, providing an assumption of the effect of environmental factors such as temperature on the genetic mutation of influenza viruses [9] . In the present study, the location information (i.e., latitude and longitudes) of 11,721 reported cases of H1N1 were collected and we explored if H1N1 genomic diversity was subject to the direct effects of temperature, precipitation, and other natural factors or the indirect effects of population density, urban development, and other social factors. For H1N1's HA mutation from 2000-2019, a simple generalized linear model (GLM) shows that, of all the seven independent variables, most variables displayed a strong significance with HA mutation, including maximum temperature, minimum temperature, nighttime light, population density, and years fixed factor. Figure 1 shows the impact of four variables on mutation, with precipitation (A) and minimum temperature (B) being selected as representatives of environmental factors, and nighttime light (C) and population density (D) as representative social factors.	./cache/cord-011536-rb8g5llp.txt	./txt/cord-011536-rb8g5llp.txt