id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-316505-tdlj5smv	Kumar, Abhai	Proteomics-based identification of plasma proteins and their association with the host–pathogen interaction in chronic typhoid carriers	2013-11-28		.txt	text/plain	4494	256	50	METHODS: Proteomics-based studies were done to determine the expression of differentially expressed proteins in the plasma of controls, acute typhoid cases, and chronic typhoid carriers. Two-dimensional (2D) gel electrophoresis and mass spectrometry techniques were used to identify newer proteins that may provide an insight into the host-pathogen interactions after Salmonella infection and in further colonization of the host leading to the chronic typhoid carrier state. The expression of proprotein convertase subtilisin, haptoglobin, and albumin in chronic typhoid carriers was significantly higher compared to those of control and acute typhoid cases (p < 0.01 and p < 0.01, respectively; Figure 3 ). typhi infection in enteric fever cases using bacteriological and serological methods and used 2D gel electrophoresis and mass spectrometry as an alternative method to differentiate chronic typhoid carriers based on alterations in the expression of proteins. When analyzed, the plasma proteome of controls, acute typhoid cases, and chronic typhoid carriers showed significant differences in the expression of four protein spots.	./cache/cord-316505-tdlj5smv.txt	./txt/cord-316505-tdlj5smv.txt