id author title date pages extension mime words sentences flesch summary cache txt cord-025380-6bagohw8 Navel, Valentin Reply 2020-05-28 .txt text/plain 756 54 59 Globally, emerging data may identify air pollution as a modulator to DNA methylation (DNAm) disturbing the inflammation process, allergic diseases development, and exacerbation risk. Considering that SARS-CoV-2 infection involves a proinflammatory cytokine storm as IL-6 and IL-1b, a putative hypothesis could explain that populations exposed to chronic air pollution are associated with a different COVID-19 incidence in line with chronic epigenetic deregulation. Affecting the immune system and the inflammatory pathways, DNAm related to air pollution could explain the disparities in COVID-19 in geographic zones in which genetically predisposed populations were living in climate favoring SARS-CoV-2 distribution. ./cache/cord-025380-6bagohw8.txt ./txt/cord-025380-6bagohw8.txt