id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-255794-55ubow92	Galván-Román, José María	IL-6 serum levels predict severity and response to Tocilizumab in COVID-19: an observational study	2020-09-30		.txt	text/plain	2800	189	61	Since 120 interleukin-6 (IL-6) is a relevant cytokine in ARDS, the blockade of its receptor with 121 Tocilizumab (TCZ) could reduce mortality and/or morbidity in severe Objective 123 To determine whether baseline IL-6 serum levels can predict the need for IMV and the 124 response to TCZ. Retrospective observational study performed in hospitalized patients diagnosed of Clinical information and laboratory findings, including IL-6 levels, were collected 128 approximately 3 and 9 days after admission to be matched with pre-and post-administration The recent exponential increase in cases of severe acute respiratory syndrome caused by 181 coronavirus 2 (SARS-CoV-2) has led the World Health Organization to declare a pandemic. To determine the variables associated with the need for IMV, we performed a multivariable 296 logistic regression analysis that was first modeled by adding all the variables with a p value 297 lower than 0.15 in the bivariable analysis, namely total lymphocyte count, D-dimer, LDH, 298 PaO 2 /FiO 2 , COPD, obesity, hypertension, C-reactive protein, and IL-6 (high vs low).	./cache/cord-255794-55ubow92.txt	./txt/cord-255794-55ubow92.txt