id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-272214-rwkfev8j	Kaplan, Allen P.	Pathways for Bradykinin Formation and Interrelationship with Complement as a Cause of Edematous Lung in COVID-19 Patients	2020-10-28		.txt	text/plain	1285	81	60	46 47 There are two general pathways for the production of bradykinin, the first being the release of 48 cellular tissue kallikrein which cleaves low molecular weight kininogen (LK) to release lys-49 bradykinin (Fig. 1) . An alternative process requires 85 carboxypeptidase activity (carboxypeptidase N in plasma and carboxypeptidase M on pulmonary 86 vascular endothelial cells) to first remove the C-terminal arg from either bradykinin (plasma 87 cascade) or lys-bradykinin (tissue kallikrein product) (Fig. 1) . Studies of gene expression in 97 bronchoalveolar lavage specimens of COVID-19 patients(5), when compared to normal control 98 specimens, reveal upregulation of multiple components that lead to bradykinin production and 99 expression for C1-INH was decreased 33-fold which would render the plasma bradykinin 102 cascade labile and overreactive as we see in C1-INH deficiency (types I and II HAE) in which 103 enzymes not adequately inhibited by C1-INH include both forms of activated factor XII, plasma 104 kallikrein, and C1r.	./cache/cord-272214-rwkfev8j.txt	./txt/cord-272214-rwkfev8j.txt