id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-347512-veavzt6d	Ueland, Thor	Elevated plasma sTIM-3 levels in severe Covid-19 patients	2020-09-21		.txt	text/plain	1926	136	58	Methods We analyzed plasma levels of myeloperoxidase (MPO, neutrophil activation), soluble (s) CD25 and soluble T cell immunoglobulin mucin domain-3 (sTIM-3) (markers of T cell activation and exhaustion) and sCD14 and sCD163 (markers of monocyte/macrophage activation) in 39 COVID-19 infected patients at hospital admission and two additional times during the first 10 days in relation to the need for ICU treatment. Results Our major findings were: (i) Severe clinical outcome (ICU) was associated with high plasma levels sTIM-3 and MPO suggesting activated and potentially exhausted T cells and activated neutrophils, respectively. Patients admitted to ICU were characterized by high levels of the T cell activation marker sCD25 and sTIM-3 in à priori analysis, and for sTIM-3 also in posthoc testing. In contrast to the T cell markers and MPO, plasma levels of sCD14 and sCD163, reflecting activation of monocytes/macrophages, were similar in ICU and non-ICU patients ( Figure 1 ).	./cache/cord-347512-veavzt6d.txt	./txt/cord-347512-veavzt6d.txt