id sid tid token lemma pos cord-007385-xcx4ic0s 1 1 key key NN cord-007385-xcx4ic0s 1 2 : : : cord-007385-xcx4ic0s 2 1 cord-007385-xcx4ic0s cord-007385-xcx4ic0s CC cord-007385-xcx4ic0s 3 1 authors author NNS cord-007385-xcx4ic0s 3 2 : : : cord-007385-xcx4ic0s 3 3 Spector Spector NNP cord-007385-xcx4ic0s 3 4 , , , cord-007385-xcx4ic0s 3 5 Sheldon Sheldon NNP cord-007385-xcx4ic0s 3 6 L. L. NNP cord-007385-xcx4ic0s 3 7 title title NN cord-007385-xcx4ic0s 3 8 : : : cord-007385-xcx4ic0s 4 1 The the DT cord-007385-xcx4ic0s 4 2 common common JJ cord-007385-xcx4ic0s 4 3 cold cold NN cord-007385-xcx4ic0s 4 4 : : : cord-007385-xcx4ic0s 4 5 Current current JJ cord-007385-xcx4ic0s 4 6 therapy therapy NN cord-007385-xcx4ic0s 4 7 and and CC cord-007385-xcx4ic0s 4 8 natural natural JJ cord-007385-xcx4ic0s 4 9 history history NN cord-007385-xcx4ic0s 4 10 ( ( -LRB- cord-007385-xcx4ic0s 4 11 ) ) -RRB- cord-007385-xcx4ic0s 4 12 ( ( -LRB- cord-007385-xcx4ic0s 4 13 ) ) -RRB- cord-007385-xcx4ic0s 5 1 ( ( -LRB- cord-007385-xcx4ic0s 5 2 ) ) -RRB- cord-007385-xcx4ic0s 5 3 date date NN cord-007385-xcx4ic0s 5 4 : : : cord-007385-xcx4ic0s 5 5 2005 2005 CD cord-007385-xcx4ic0s 5 6 - - SYM cord-007385-xcx4ic0s 5 7 11 11 CD cord-007385-xcx4ic0s 5 8 - - SYM cord-007385-xcx4ic0s 5 9 30 30 CD cord-007385-xcx4ic0s 5 10 journal journal NN cord-007385-xcx4ic0s 5 11 : : : cord-007385-xcx4ic0s 5 12 J J NNP cord-007385-xcx4ic0s 5 13 Allergy Allergy NNP cord-007385-xcx4ic0s 5 14 Clin Clin NNP cord-007385-xcx4ic0s 5 15 Immunol Immunol NNP cord-007385-xcx4ic0s 5 16 DOI DOI NNP cord-007385-xcx4ic0s 5 17 : : : cord-007385-xcx4ic0s 5 18 10.1016 10.1016 CD cord-007385-xcx4ic0s 5 19 / / SYM cord-007385-xcx4ic0s 5 20 s0091 s0091 NNP cord-007385-xcx4ic0s 5 21 - - HYPH cord-007385-xcx4ic0s 5 22 6749(95)70218 6749(95)70218 NNP cord-007385-xcx4ic0s 5 23 - - HYPH cord-007385-xcx4ic0s 5 24 0 0 CD cord-007385-xcx4ic0s 5 25 sha sha NN cord-007385-xcx4ic0s 5 26 : : : cord-007385-xcx4ic0s 5 27 d2b8c64e77ae824f20369bd17ccb3b5de5bd8bd5 d2b8c64e77ae824f20369bd17ccb3b5de5bd8bd5 NNP cord-007385-xcx4ic0s 5 28 doc_id doc_id CD cord-007385-xcx4ic0s 5 29 : : : cord-007385-xcx4ic0s 5 30 7385 7385 CD cord-007385-xcx4ic0s 5 31 cord_uid cord_uid NNS cord-007385-xcx4ic0s 5 32 : : : cord-007385-xcx4ic0s 6 1 xcx4ic0s xcx4ic0s LS cord-007385-xcx4ic0s 7 1 Despite despite IN cord-007385-xcx4ic0s 7 2 its -PRON- PRP$ cord-007385-xcx4ic0s 7 3 prevalence prevalence NN cord-007385-xcx4ic0s 7 4 , , , cord-007385-xcx4ic0s 7 5 the the DT cord-007385-xcx4ic0s 7 6 common common JJ cord-007385-xcx4ic0s 7 7 cold cold NN cord-007385-xcx4ic0s 7 8 is be VBZ cord-007385-xcx4ic0s 7 9 complicated complicated JJ cord-007385-xcx4ic0s 7 10 and and CC cord-007385-xcx4ic0s 7 11 can can MD cord-007385-xcx4ic0s 7 12 be be VB cord-007385-xcx4ic0s 7 13 difficult difficult JJ cord-007385-xcx4ic0s 7 14 to to TO cord-007385-xcx4ic0s 7 15 treat treat VB cord-007385-xcx4ic0s 7 16 , , , cord-007385-xcx4ic0s 7 17 even even RB cord-007385-xcx4ic0s 7 18 symptomatically symptomatically RB cord-007385-xcx4ic0s 7 19 . . . cord-007385-xcx4ic0s 8 1 There there EX cord-007385-xcx4ic0s 8 2 is be VBZ cord-007385-xcx4ic0s 8 3 still still RB cord-007385-xcx4ic0s 8 4 no no DT cord-007385-xcx4ic0s 8 5 cure cure NN cord-007385-xcx4ic0s 8 6 for for IN cord-007385-xcx4ic0s 8 7 the the DT cord-007385-xcx4ic0s 8 8 myriad myriad NNS cord-007385-xcx4ic0s 8 9 of of IN cord-007385-xcx4ic0s 8 10 viruses virus NNS cord-007385-xcx4ic0s 8 11 that that WDT cord-007385-xcx4ic0s 8 12 cause cause VBP cord-007385-xcx4ic0s 8 13 the the DT cord-007385-xcx4ic0s 8 14 common common JJ cord-007385-xcx4ic0s 8 15 cold cold NN cord-007385-xcx4ic0s 8 16 . . . cord-007385-xcx4ic0s 9 1 Many many JJ cord-007385-xcx4ic0s 9 2 of of IN cord-007385-xcx4ic0s 9 3 the the DT cord-007385-xcx4ic0s 9 4 most most RBS cord-007385-xcx4ic0s 9 5 popular popular JJ cord-007385-xcx4ic0s 9 6 remedies remedy NNS cord-007385-xcx4ic0s 9 7 are be VBP cord-007385-xcx4ic0s 9 8 either either CC cord-007385-xcx4ic0s 9 9 ineffective ineffective JJ cord-007385-xcx4ic0s 9 10 or or CC cord-007385-xcx4ic0s 9 11 counterproductive counterproductive JJ cord-007385-xcx4ic0s 9 12 . . . cord-007385-xcx4ic0s 10 1 This this DT cord-007385-xcx4ic0s 10 2 paper paper NN cord-007385-xcx4ic0s 10 3 reviews review VBZ cord-007385-xcx4ic0s 10 4 the the DT cord-007385-xcx4ic0s 10 5 causes cause NNS cord-007385-xcx4ic0s 10 6 and and CC cord-007385-xcx4ic0s 10 7 course course NN cord-007385-xcx4ic0s 10 8 of of IN cord-007385-xcx4ic0s 10 9 upper upper JJ cord-007385-xcx4ic0s 10 10 respiratory respiratory JJ cord-007385-xcx4ic0s 10 11 infections infection NNS cord-007385-xcx4ic0s 10 12 , , , cord-007385-xcx4ic0s 10 13 and and CC cord-007385-xcx4ic0s 10 14 discusses discuss VBZ cord-007385-xcx4ic0s 10 15 treatment treatment NN cord-007385-xcx4ic0s 10 16 options option NNS cord-007385-xcx4ic0s 10 17 , , , cord-007385-xcx4ic0s 10 18 including include VBG cord-007385-xcx4ic0s 10 19 a a DT cord-007385-xcx4ic0s 10 20 new new JJ cord-007385-xcx4ic0s 10 21 anticholinergic anticholinergic JJ cord-007385-xcx4ic0s 10 22 aqueous aqueous JJ cord-007385-xcx4ic0s 10 23 formulation formulation NN cord-007385-xcx4ic0s 10 24 for for IN cord-007385-xcx4ic0s 10 25 controlling control VBG cord-007385-xcx4ic0s 10 26 rhinorrhea rhinorrhea NNP cord-007385-xcx4ic0s 10 27 . . . cord-007385-xcx4ic0s 11 1 ( ( -LRB- cord-007385-xcx4ic0s 11 2 J J NNP cord-007385-xcx4ic0s 11 3 ALLERGY ALLERGY NNP cord-007385-xcx4ic0s 11 4 CLIN CLIN NNP cord-007385-xcx4ic0s 11 5 IMMUNOL IMMUNOL NNP cord-007385-xcx4ic0s 12 1 1995;95:1133 1995;95:1133 CD cord-007385-xcx4ic0s 12 2 - - SYM cord-007385-xcx4ic0s 12 3 8 8 CD cord-007385-xcx4ic0s 12 4 . . . cord-007385-xcx4ic0s 12 5 ) ) -RRB- cord-007385-xcx4ic0s 13 1 As as IN cord-007385-xcx4ic0s 13 2 new new JJ cord-007385-xcx4ic0s 13 3 data datum NNS cord-007385-xcx4ic0s 13 4 emerge emerge VBP cord-007385-xcx4ic0s 13 5 regarding regard VBG cord-007385-xcx4ic0s 13 6 the the DT cord-007385-xcx4ic0s 13 7 pathophysiology pathophysiology NN cord-007385-xcx4ic0s 13 8 of of IN cord-007385-xcx4ic0s 13 9 upper upper JJ cord-007385-xcx4ic0s 13 10 respiratory respiratory JJ cord-007385-xcx4ic0s 13 11 infections infection NNS cord-007385-xcx4ic0s 13 12 ( ( -LRB- cord-007385-xcx4ic0s 13 13 URIs URIs NNP cord-007385-xcx4ic0s 13 14 ) ) -RRB- cord-007385-xcx4ic0s 13 15 , , , cord-007385-xcx4ic0s 13 16 we -PRON- PRP cord-007385-xcx4ic0s 13 17 continue continue VBP cord-007385-xcx4ic0s 13 18 to to TO cord-007385-xcx4ic0s 13 19 gain gain VB cord-007385-xcx4ic0s 13 20 new new JJ cord-007385-xcx4ic0s 13 21 insight insight NN cord-007385-xcx4ic0s 13 22 into into IN cord-007385-xcx4ic0s 13 23 their -PRON- PRP$ cord-007385-xcx4ic0s 13 24 treatment treatment NN cord-007385-xcx4ic0s 13 25 and and CC cord-007385-xcx4ic0s 13 26 possible possible JJ cord-007385-xcx4ic0s 13 27 complications complication NNS cord-007385-xcx4ic0s 13 28 . . . cord-007385-xcx4ic0s 14 1 It -PRON- PRP cord-007385-xcx4ic0s 14 2 has have VBZ cord-007385-xcx4ic0s 14 3 been be VBN cord-007385-xcx4ic0s 14 4 estimated estimate VBN cord-007385-xcx4ic0s 14 5 that that IN cord-007385-xcx4ic0s 14 6 the the DT cord-007385-xcx4ic0s 14 7 average average JJ cord-007385-xcx4ic0s 14 8 preschool preschool NN cord-007385-xcx4ic0s 14 9 child child NN cord-007385-xcx4ic0s 14 10 experiences experience VBZ cord-007385-xcx4ic0s 14 11 six six CD cord-007385-xcx4ic0s 14 12 to to TO cord-007385-xcx4ic0s 14 13 ten ten CD cord-007385-xcx4ic0s 14 14 URIs uri NNS cord-007385-xcx4ic0s 14 15 , , , cord-007385-xcx4ic0s 14 16 or or CC cord-007385-xcx4ic0s 14 17 " " `` cord-007385-xcx4ic0s 14 18 colds cold NNS cord-007385-xcx4ic0s 14 19 , , , cord-007385-xcx4ic0s 14 20 " " '' cord-007385-xcx4ic0s 14 21 per per IN cord-007385-xcx4ic0s 14 22 year year NN cord-007385-xcx4ic0s 14 23 ; ; : cord-007385-xcx4ic0s 14 24 the the DT cord-007385-xcx4ic0s 14 25 average average JJ cord-007385-xcx4ic0s 14 26 adult adult NN cord-007385-xcx4ic0s 14 27 has have VBZ cord-007385-xcx4ic0s 14 28 two two CD cord-007385-xcx4ic0s 14 29 to to TO cord-007385-xcx4ic0s 14 30 four four CD cord-007385-xcx4ic0s 14 31 ? ? . cord-007385-xcx4ic0s 15 1 The the DT cord-007385-xcx4ic0s 15 2 effects effect NNS cord-007385-xcx4ic0s 15 3 of of IN cord-007385-xcx4ic0s 15 4 the the DT cord-007385-xcx4ic0s 15 5 common common JJ cord-007385-xcx4ic0s 15 6 cold cold NN cord-007385-xcx4ic0s 15 7 can can MD cord-007385-xcx4ic0s 15 8 be be VB cord-007385-xcx4ic0s 15 9 uncommonly uncommonly RB cord-007385-xcx4ic0s 15 10 disruptive disruptive JJ cord-007385-xcx4ic0s 15 11 , , , cord-007385-xcx4ic0s 15 12 forcing force VBG cord-007385-xcx4ic0s 15 13 otherwise otherwise RB cord-007385-xcx4ic0s 15 14 normal normal JJ cord-007385-xcx4ic0s 15 15 individuals individual NNS cord-007385-xcx4ic0s 15 16 to to TO cord-007385-xcx4ic0s 15 17 miss miss VB cord-007385-xcx4ic0s 15 18 work work NN cord-007385-xcx4ic0s 15 19 , , , cord-007385-xcx4ic0s 15 20 school school NN cord-007385-xcx4ic0s 15 21 , , , cord-007385-xcx4ic0s 15 22 or or CC cord-007385-xcx4ic0s 15 23 other other JJ cord-007385-xcx4ic0s 15 24 important important JJ cord-007385-xcx4ic0s 15 25 activities activity NNS cord-007385-xcx4ic0s 15 26 . . . cord-007385-xcx4ic0s 16 1 Individuals individual NNS cord-007385-xcx4ic0s 16 2 who who WP cord-007385-xcx4ic0s 16 3 are be VBP cord-007385-xcx4ic0s 16 4 at at IN cord-007385-xcx4ic0s 16 5 increased increase VBN cord-007385-xcx4ic0s 16 6 risk risk NN cord-007385-xcx4ic0s 16 7 , , , cord-007385-xcx4ic0s 16 8 such such JJ cord-007385-xcx4ic0s 16 9 as as IN cord-007385-xcx4ic0s 16 10 those those DT cord-007385-xcx4ic0s 16 11 with with IN cord-007385-xcx4ic0s 16 12 bronchitis bronchitis NN cord-007385-xcx4ic0s 16 13 or or CC cord-007385-xcx4ic0s 16 14 asthma asthma NN cord-007385-xcx4ic0s 16 15 , , , cord-007385-xcx4ic0s 16 16 may may MD cord-007385-xcx4ic0s 16 17 also also RB cord-007385-xcx4ic0s 16 18 experience experience VB cord-007385-xcx4ic0s 16 19 a a DT cord-007385-xcx4ic0s 16 20 life life NN cord-007385-xcx4ic0s 16 21 - - HYPH cord-007385-xcx4ic0s 16 22 threatening threaten VBG cord-007385-xcx4ic0s 16 23 exacerbation exacerbation NN cord-007385-xcx4ic0s 16 24 of of IN cord-007385-xcx4ic0s 16 25 their -PRON- PRP$ cord-007385-xcx4ic0s 16 26 underlying underlying JJ cord-007385-xcx4ic0s 16 27 conditions condition NNS cord-007385-xcx4ic0s 16 28 . . . cord-007385-xcx4ic0s 17 1 The the DT cord-007385-xcx4ic0s 17 2 average average JJ cord-007385-xcx4ic0s 17 3 annual annual JJ cord-007385-xcx4ic0s 17 4 expenditure expenditure NN cord-007385-xcx4ic0s 17 5 for for IN cord-007385-xcx4ic0s 17 6 various various JJ cord-007385-xcx4ic0s 17 7 cold cold JJ cord-007385-xcx4ic0s 17 8 treatments treatment NNS cord-007385-xcx4ic0s 17 9 exceeds exceed VBZ cord-007385-xcx4ic0s 17 10 $ $ $ cord-007385-xcx4ic0s 17 11 2 2 CD cord-007385-xcx4ic0s 17 12 billion billion CD cord-007385-xcx4ic0s 17 13 in in IN cord-007385-xcx4ic0s 17 14 the the DT cord-007385-xcx4ic0s 17 15 United United NNP cord-007385-xcx4ic0s 17 16 States States NNP cord-007385-xcx4ic0s 17 17 . . . cord-007385-xcx4ic0s 18 1 This this DT cord-007385-xcx4ic0s 18 2 statistic statistic NN cord-007385-xcx4ic0s 18 3 becomes become VBZ cord-007385-xcx4ic0s 18 4 even even RB cord-007385-xcx4ic0s 18 5 more more RBR cord-007385-xcx4ic0s 18 6 provocative provocative JJ cord-007385-xcx4ic0s 18 7 when when WRB cord-007385-xcx4ic0s 18 8 we -PRON- PRP cord-007385-xcx4ic0s 18 9 consider consider VBP cord-007385-xcx4ic0s 18 10 that that IN cord-007385-xcx4ic0s 18 11 one one CD cord-007385-xcx4ic0s 18 12 of of IN cord-007385-xcx4ic0s 18 13 every every DT cord-007385-xcx4ic0s 18 14 three three CD cord-007385-xcx4ic0s 18 15 individuals individual NNS cord-007385-xcx4ic0s 18 16 with with IN cord-007385-xcx4ic0s 18 17 a a DT cord-007385-xcx4ic0s 18 18 confirmed confirm VBN cord-007385-xcx4ic0s 18 19 infection infection NN cord-007385-xcx4ic0s 18 20 has have VBZ cord-007385-xcx4ic0s 18 21 no no DT cord-007385-xcx4ic0s 18 22 apparent apparent JJ cord-007385-xcx4ic0s 18 23 symptoms symptom NNS cord-007385-xcx4ic0s 18 24 of of IN cord-007385-xcx4ic0s 18 25 a a DT cord-007385-xcx4ic0s 18 26 cold cold NN cord-007385-xcx4ic0s 18 27 . . . cord-007385-xcx4ic0s 19 1 Viruses virus NNS cord-007385-xcx4ic0s 19 2 that that WDT cord-007385-xcx4ic0s 19 3 cause cause VBP cord-007385-xcx4ic0s 19 4 colds cold NNS cord-007385-xcx4ic0s 19 5 can can MD cord-007385-xcx4ic0s 19 6 be be VB cord-007385-xcx4ic0s 19 7 spread spread VBN cord-007385-xcx4ic0s 19 8 through through IN cord-007385-xcx4ic0s 19 9 contact contact NN cord-007385-xcx4ic0s 19 10 with with IN cord-007385-xcx4ic0s 19 11 inanimate inanimate JJ cord-007385-xcx4ic0s 19 12 surfaces surface NNS cord-007385-xcx4ic0s 19 13 , , , cord-007385-xcx4ic0s 19 14 2 2 CD cord-007385-xcx4ic0s 19 15 as as RB cord-007385-xcx4ic0s 19 16 well well RB cord-007385-xcx4ic0s 19 17 as as IN cord-007385-xcx4ic0s 19 18 by by IN cord-007385-xcx4ic0s 19 19 hand hand NN cord-007385-xcx4ic0s 19 20 - - HYPH cord-007385-xcx4ic0s 19 21 to to IN cord-007385-xcx4ic0s 19 22 - - HYPH cord-007385-xcx4ic0s 19 23 hand hand NN cord-007385-xcx4ic0s 19 24 contact contact NN cord-007385-xcx4ic0s 19 25 ? ? . cord-007385-xcx4ic0s 20 1 Seasonal seasonal JJ cord-007385-xcx4ic0s 20 2 variations variation NNS cord-007385-xcx4ic0s 20 3 in in IN cord-007385-xcx4ic0s 20 4 cold cold JJ cord-007385-xcx4ic0s 20 5 patterns pattern NNS cord-007385-xcx4ic0s 20 6 have have VBP cord-007385-xcx4ic0s 20 7 long long RB cord-007385-xcx4ic0s 20 8 been be VBN cord-007385-xcx4ic0s 20 9 recognized recognize VBN cord-007385-xcx4ic0s 20 10 . . . cord-007385-xcx4ic0s 21 1 Generally generally RB cord-007385-xcx4ic0s 21 2 there there EX cord-007385-xcx4ic0s 21 3 are be VBP cord-007385-xcx4ic0s 21 4 fewer few JJR cord-007385-xcx4ic0s 21 5 colds cold NNS cord-007385-xcx4ic0s 21 6 in in IN cord-007385-xcx4ic0s 21 7 the the DT cord-007385-xcx4ic0s 21 8 warm warm JJ cord-007385-xcx4ic0s 21 9 summer summer NN cord-007385-xcx4ic0s 21 10 months month NNS cord-007385-xcx4ic0s 21 11 and and CC cord-007385-xcx4ic0s 21 12 more more JJR cord-007385-xcx4ic0s 21 13 colds cold NNS cord-007385-xcx4ic0s 21 14 during during IN cord-007385-xcx4ic0s 21 15 periods period NNS cord-007385-xcx4ic0s 21 16 of of IN cord-007385-xcx4ic0s 21 17 crowding crowding NN cord-007385-xcx4ic0s 21 18 , , , cord-007385-xcx4ic0s 21 19 particularly particularly RB cord-007385-xcx4ic0s 21 20 the the DT cord-007385-xcx4ic0s 21 21 fall fall NN cord-007385-xcx4ic0s 21 22 . . . cord-007385-xcx4ic0s 22 1 Upper upper JJ cord-007385-xcx4ic0s 22 2 respirato~ respirato~ NNP cord-007385-xcx4ic0s 22 3 infection infection NN cord-007385-xcx4ic0s 22 4 seem seem VBP cord-007385-xcx4ic0s 22 5 to to TO cord-007385-xcx4ic0s 22 6 be be VB cord-007385-xcx4ic0s 22 7 a a DT cord-007385-xcx4ic0s 22 8 significant significant JJ cord-007385-xcx4ic0s 22 9 factor factor NN cord-007385-xcx4ic0s 22 10 in in IN cord-007385-xcx4ic0s 22 11 cold cold JJ cord-007385-xcx4ic0s 22 12 epidemiology epidemiology NN cord-007385-xcx4ic0s 22 13 . . . cord-007385-xcx4ic0s 23 1 Folklore folklore NN cord-007385-xcx4ic0s 23 2 is be VBZ cord-007385-xcx4ic0s 23 3 somewhat somewhat RB cord-007385-xcx4ic0s 23 4 at at IN cord-007385-xcx4ic0s 23 5 odds odd NNS cord-007385-xcx4ic0s 23 6 with with IN cord-007385-xcx4ic0s 23 7 modern modern JJ cord-007385-xcx4ic0s 23 8 science science NN cord-007385-xcx4ic0s 23 9 over over IN cord-007385-xcx4ic0s 23 10 this this DT cord-007385-xcx4ic0s 23 11 issue issue NN cord-007385-xcx4ic0s 23 12 ; ; : cord-007385-xcx4ic0s 23 13 there there EX cord-007385-xcx4ic0s 23 14 are be VBP cord-007385-xcx4ic0s 23 15 many many JJ cord-007385-xcx4ic0s 23 16 cultures culture NNS cord-007385-xcx4ic0s 23 17 where where WRB cord-007385-xcx4ic0s 23 18 youngsters youngster NNS cord-007385-xcx4ic0s 23 19 who who WP cord-007385-xcx4ic0s 23 20 have have VBP cord-007385-xcx4ic0s 23 21 a a DT cord-007385-xcx4ic0s 23 22 " " `` cord-007385-xcx4ic0s 23 23 cold cold JJ cord-007385-xcx4ic0s 23 24 " " '' cord-007385-xcx4ic0s 23 25 are be VBP cord-007385-xcx4ic0s 23 26 dressed dress VBN cord-007385-xcx4ic0s 23 27 sufficiently sufficiently RB cord-007385-xcx4ic0s 23 28 to to TO cord-007385-xcx4ic0s 23 29 keep keep VB cord-007385-xcx4ic0s 23 30 them -PRON- PRP cord-007385-xcx4ic0s 23 31 warm warm JJ cord-007385-xcx4ic0s 23 32 on on IN cord-007385-xcx4ic0s 23 33 the the DT cord-007385-xcx4ic0s 23 34 coldest cold JJS cord-007385-xcx4ic0s 23 35 winter winter NN cord-007385-xcx4ic0s 23 36 night night NN cord-007385-xcx4ic0s 23 37 , , , cord-007385-xcx4ic0s 23 38 even even RB cord-007385-xcx4ic0s 23 39 when when WRB cord-007385-xcx4ic0s 23 40 the the DT cord-007385-xcx4ic0s 23 41 outside outside JJ cord-007385-xcx4ic0s 23 42 temperature temperature NN cord-007385-xcx4ic0s 23 43 is be VBZ cord-007385-xcx4ic0s 23 44 tropical tropical JJ cord-007385-xcx4ic0s 23 45 . . . cord-007385-xcx4ic0s 24 1 Colds cold NNS cord-007385-xcx4ic0s 24 2 are be VBP cord-007385-xcx4ic0s 24 3 caused cause VBN cord-007385-xcx4ic0s 24 4 by by IN cord-007385-xcx4ic0s 24 5 a a DT cord-007385-xcx4ic0s 24 6 wide wide JJ cord-007385-xcx4ic0s 24 7 variety variety NN cord-007385-xcx4ic0s 24 8 , , , cord-007385-xcx4ic0s 24 9 of of IN cord-007385-xcx4ic0s 24 10 viruses virus NNS cord-007385-xcx4ic0s 24 11 ( ( -LRB- cord-007385-xcx4ic0s 24 12 Table table NN cord-007385-xcx4ic0s 24 13 I i CD cord-007385-xcx4ic0s 24 14 ) ) -RRB- cord-007385-xcx4ic0s 24 15 . . . cord-007385-xcx4ic0s 25 1 The the DT cord-007385-xcx4ic0s 25 2 rhinoviruses rhinovirus NNS cord-007385-xcx4ic0s 25 3 , , , cord-007385-xcx4ic0s 25 4 which which WDT cord-007385-xcx4ic0s 25 5 account account VBP cord-007385-xcx4ic0s 25 6 for for IN cord-007385-xcx4ic0s 25 7 more more JJR cord-007385-xcx4ic0s 25 8 than than IN cord-007385-xcx4ic0s 25 9 30 30 CD cord-007385-xcx4ic0s 25 10 % % NN cord-007385-xcx4ic0s 25 11 of of IN cord-007385-xcx4ic0s 25 12 colds cold NNS cord-007385-xcx4ic0s 25 13 in in IN cord-007385-xcx4ic0s 25 14 adults adult NNS cord-007385-xcx4ic0s 25 15 , , , cord-007385-xcx4ic0s 25 16 have have VBP cord-007385-xcx4ic0s 25 17 more more JJR cord-007385-xcx4ic0s 25 18 than than IN cord-007385-xcx4ic0s 25 19 100 100 CD cord-007385-xcx4ic0s 25 20 antigenically antigenically RB cord-007385-xcx4ic0s 25 21 different different JJ cord-007385-xcx4ic0s 25 22 types type NNS cord-007385-xcx4ic0s 25 23 . . . cord-007385-xcx4ic0s 26 1 Coronaviruses Coronaviruses NNP cord-007385-xcx4ic0s 26 2 also also RB cord-007385-xcx4ic0s 26 3 appea appea VBZ cord-007385-xcx4ic0s 26 4 r r NN cord-007385-xcx4ic0s 26 5 to to TO cord-007385-xcx4ic0s 26 6 be be VB cord-007385-xcx4ic0s 26 7 responsible responsible JJ cord-007385-xcx4ic0s 26 8 for for IN cord-007385-xcx4ic0s 26 9 a a DT cord-007385-xcx4ic0s 26 10 large large JJ cord-007385-xcx4ic0s 26 11 percentage percentage NN cord-007385-xcx4ic0s 26 12 of of IN cord-007385-xcx4ic0s 26 13 colds cold NNS cord-007385-xcx4ic0s 26 14 , , , cord-007385-xcx4ic0s 26 15 but but CC cord-007385-xcx4ic0s 26 16 precisely precisely RB cord-007385-xcx4ic0s 26 17 what what WP cord-007385-xcx4ic0s 26 18 that that DT cord-007385-xcx4ic0s 26 19 percentage percentage NN cord-007385-xcx4ic0s 26 20 is be VBZ cord-007385-xcx4ic0s 26 21 compared compare VBN cord-007385-xcx4ic0s 26 22 with with IN cord-007385-xcx4ic0s 26 23 parainfluenza parainfluenza NN cord-007385-xcx4ic0s 26 24 or or CC cord-007385-xcx4ic0s 26 25 respiratory respiratory JJ cord-007385-xcx4ic0s 26 26 syncytial syncytial JJ cord-007385-xcx4ic0s 26 27 viruses virus NNS cord-007385-xcx4ic0s 26 28 has have VBZ cord-007385-xcx4ic0s 26 29 not not RB cord-007385-xcx4ic0s 26 30 yet yet RB cord-007385-xcx4ic0s 26 31 been be VBN cord-007385-xcx4ic0s 26 32 well well RB cord-007385-xcx4ic0s 26 33 established establish VBN cord-007385-xcx4ic0s 26 34 . . . cord-007385-xcx4ic0s 27 1 Certain certain JJ cord-007385-xcx4ic0s 27 2 viruses virus NNS cord-007385-xcx4ic0s 27 3 appear appear VBP cord-007385-xcx4ic0s 27 4 to to TO cord-007385-xcx4ic0s 27 5 be be VB cord-007385-xcx4ic0s 27 6 more more RBR cord-007385-xcx4ic0s 27 7 common common JJ cord-007385-xcx4ic0s 27 8 in in IN cord-007385-xcx4ic0s 27 9 children child NNS cord-007385-xcx4ic0s 27 10 than than IN cord-007385-xcx4ic0s 27 11 adults adult NNS cord-007385-xcx4ic0s 27 12 , , , cord-007385-xcx4ic0s 27 13 but but CC cord-007385-xcx4ic0s 27 14 in in IN cord-007385-xcx4ic0s 27 15 general general JJ cord-007385-xcx4ic0s 27 16 , , , cord-007385-xcx4ic0s 27 17 viruses virus NNS cord-007385-xcx4ic0s 27 18 appear appear VBP cord-007385-xcx4ic0s 27 19 in in IN cord-007385-xcx4ic0s 27 20 roughly roughly RB cord-007385-xcx4ic0s 27 21 the the DT cord-007385-xcx4ic0s 27 22 same same JJ cord-007385-xcx4ic0s 27 23 proportions proportion NNS cord-007385-xcx4ic0s 27 24 in in IN cord-007385-xcx4ic0s 27 25 both both DT cord-007385-xcx4ic0s 27 26 populations population NNS cord-007385-xcx4ic0s 27 27 . . . cord-007385-xcx4ic0s 28 1 Some some DT cord-007385-xcx4ic0s 28 2 viruses virus NNS cord-007385-xcx4ic0s 28 3 may may MD cord-007385-xcx4ic0s 28 4 be be VB cord-007385-xcx4ic0s 28 5 associated associate VBN cord-007385-xcx4ic0s 28 6 with with IN cord-007385-xcx4ic0s 28 7 more more JJR cord-007385-xcx4ic0s 28 8 severe severe JJ cord-007385-xcx4ic0s 28 9 symptoms symptom NNS cord-007385-xcx4ic0s 28 10 than than IN cord-007385-xcx4ic0s 28 11 others other NNS cord-007385-xcx4ic0s 28 12 , , , cord-007385-xcx4ic0s 28 13 for for IN cord-007385-xcx4ic0s 28 14 example example NN cord-007385-xcx4ic0s 28 15 , , , cord-007385-xcx4ic0s 28 16 the the DT cord-007385-xcx4ic0s 28 17 exacerbation exacerbation NN cord-007385-xcx4ic0s 28 18 of of IN cord-007385-xcx4ic0s 28 19 asthma asthma NN cord-007385-xcx4ic0s 28 20 seen see VBN cord-007385-xcx4ic0s 28 21 with with IN cord-007385-xcx4ic0s 28 22 respiratory respiratory JJ cord-007385-xcx4ic0s 28 23 syncytial syncytial JJ cord-007385-xcx4ic0s 28 24 virus virus NN cord-007385-xcx4ic0s 28 25 . . . cord-007385-xcx4ic0s 29 1 However however RB cord-007385-xcx4ic0s 29 2 , , , cord-007385-xcx4ic0s 29 3 the the DT cord-007385-xcx4ic0s 29 4 most most RBS cord-007385-xcx4ic0s 29 5 significant significant JJ cord-007385-xcx4ic0s 29 6 factor factor NN cord-007385-xcx4ic0s 29 7 in in IN cord-007385-xcx4ic0s 29 8 the the DT cord-007385-xcx4ic0s 29 9 severity severity NN cord-007385-xcx4ic0s 29 10 of of IN cord-007385-xcx4ic0s 29 11 a a DT cord-007385-xcx4ic0s 29 12 viral viral JJ cord-007385-xcx4ic0s 29 13 infection infection NN cord-007385-xcx4ic0s 29 14 seems seem VBZ cord-007385-xcx4ic0s 29 15 to to TO cord-007385-xcx4ic0s 29 16 be be VB cord-007385-xcx4ic0s 29 17 the the DT cord-007385-xcx4ic0s 29 18 incubation incubation NN cord-007385-xcx4ic0s 29 19 period period NN cord-007385-xcx4ic0s 29 20 . . . cord-007385-xcx4ic0s 30 1 4 4 CD cord-007385-xcx4ic0s 30 2 Various various JJ cord-007385-xcx4ic0s 30 3 factors factor NNS cord-007385-xcx4ic0s 30 4 are be VBP cord-007385-xcx4ic0s 30 5 thought think VBN cord-007385-xcx4ic0s 30 6 to to TO cord-007385-xcx4ic0s 30 7 increase increase VB cord-007385-xcx4ic0s 30 8 susceptibility susceptibility NN cord-007385-xcx4ic0s 30 9 to to IN cord-007385-xcx4ic0s 30 10 URIs uri NNS cord-007385-xcx4ic0s 30 11 . . . cord-007385-xcx4ic0s 31 1 There there EX cord-007385-xcx4ic0s 31 2 seems seem VBZ cord-007385-xcx4ic0s 31 3 to to TO cord-007385-xcx4ic0s 31 4 be be VB cord-007385-xcx4ic0s 31 5 a a DT cord-007385-xcx4ic0s 31 6 relationship relationship NN cord-007385-xcx4ic0s 31 7 between between IN cord-007385-xcx4ic0s 31 8 colds cold NNS cord-007385-xcx4ic0s 31 9 and and CC cord-007385-xcx4ic0s 31 10 stress stress NN cord-007385-xcx4ic0s 31 11 . . . cord-007385-xcx4ic0s 32 1 In in IN cord-007385-xcx4ic0s 32 2 assessing assess VBG cord-007385-xcx4ic0s 32 3 the the DT cord-007385-xcx4ic0s 32 4 differences difference NNS cord-007385-xcx4ic0s 32 5 between between IN cord-007385-xcx4ic0s 32 6 symptomatic symptomatic JJ cord-007385-xcx4ic0s 32 7 and and CC cord-007385-xcx4ic0s 32 8 asymptomatic asymptomatic JJ cord-007385-xcx4ic0s 32 9 individuals individual NNS cord-007385-xcx4ic0s 32 10 with with IN cord-007385-xcx4ic0s 32 11 confirmed confirm VBN cord-007385-xcx4ic0s 32 12 viral viral JJ cord-007385-xcx4ic0s 32 13 infections infection NNS cord-007385-xcx4ic0s 32 14 , , , cord-007385-xcx4ic0s 32 15 Stone Stone NNP cord-007385-xcx4ic0s 32 16 6 6 CD cord-007385-xcx4ic0s 32 17 found find VBD cord-007385-xcx4ic0s 32 18 an an DT cord-007385-xcx4ic0s 32 19 association association NN cord-007385-xcx4ic0s 32 20 similar similar JJ cord-007385-xcx4ic0s 32 21 to to IN cord-007385-xcx4ic0s 32 22 a a DT cord-007385-xcx4ic0s 32 23 dose dose JJ cord-007385-xcx4ic0s 32 24 - - HYPH cord-007385-xcx4ic0s 32 25 response response NN cord-007385-xcx4ic0s 32 26 between between IN cord-007385-xcx4ic0s 32 27 psychologic psychologic JJ cord-007385-xcx4ic0s 32 28 stress stress NN cord-007385-xcx4ic0s 32 29 and and CC cord-007385-xcx4ic0s 32 30 increased increase VBN cord-007385-xcx4ic0s 32 31 risk risk NN cord-007385-xcx4ic0s 32 32 of of IN cord-007385-xcx4ic0s 32 33 acute acute JJ cord-007385-xcx4ic0s 32 34 infectious infectious JJ cord-007385-xcx4ic0s 32 35 respiratory respiratory JJ cord-007385-xcx4ic0s 32 36 illness illness NN cord-007385-xcx4ic0s 32 37 ; ; : cord-007385-xcx4ic0s 32 38 the the DT cord-007385-xcx4ic0s 32 39 risk risk NN cord-007385-xcx4ic0s 32 40 involved involve VBN cord-007385-xcx4ic0s 32 41 increased increase VBN cord-007385-xcx4ic0s 32 42 rates rate NNS cord-007385-xcx4ic0s 32 43 of of IN cord-007385-xcx4ic0s 32 44 infections infection NNS cord-007385-xcx4ic0s 32 45 rather rather RB cord-007385-xcx4ic0s 32 46 than than IN cord-007385-xcx4ic0s 32 47 frequency frequency NN cord-007385-xcx4ic0s 32 48 of of IN cord-007385-xcx4ic0s 32 49 symptoms symptom NNS cord-007385-xcx4ic0s 32 50 after after IN cord-007385-xcx4ic0s 32 51 infection infection NN cord-007385-xcx4ic0s 32 52 . . . cord-007385-xcx4ic0s 33 1 Smokers smoker NNS cord-007385-xcx4ic0s 33 2 are be VBP cord-007385-xcx4ic0s 33 3 at at IN cord-007385-xcx4ic0s 33 4 greater great JJR cord-007385-xcx4ic0s 33 5 risk risk NN cord-007385-xcx4ic0s 33 6 than than IN cord-007385-xcx4ic0s 33 7 nonsmokers nonsmoker NNS cord-007385-xcx4ic0s 33 8 to to TO cord-007385-xcx4ic0s 33 9 develop develop VB cord-007385-xcx4ic0s 33 10 both both DT cord-007385-xcx4ic0s 33 11 infections infection NNS cord-007385-xcx4ic0s 33 12 and and CC cord-007385-xcx4ic0s 33 13 symptoms symptom NNS cord-007385-xcx4ic0s 33 14 after after IN cord-007385-xcx4ic0s 33 15 infection infection NN cord-007385-xcx4ic0s 33 16 . . . cord-007385-xcx4ic0s 34 1 6 6 CD cord-007385-xcx4ic0s 35 1 It -PRON- PRP cord-007385-xcx4ic0s 35 2 also also RB cord-007385-xcx4ic0s 35 3 appears appear VBZ cord-007385-xcx4ic0s 35 4 that that IN cord-007385-xcx4ic0s 35 5 certain certain JJ cord-007385-xcx4ic0s 35 6 drugs drug NNS cord-007385-xcx4ic0s 35 7 may may MD cord-007385-xcx4ic0s 35 8 increase increase VB cord-007385-xcx4ic0s 35 9 susceptibility susceptibility NN cord-007385-xcx4ic0s 35 10 to to IN cord-007385-xcx4ic0s 35 11 colds cold NNS cord-007385-xcx4ic0s 35 12 . . . cord-007385-xcx4ic0s 36 1 Aspirin aspirin NN cord-007385-xcx4ic0s 36 2 and and CC cord-007385-xcx4ic0s 36 3 acetaminophen acetaminophen NN cord-007385-xcx4ic0s 36 4 suppress suppress VB cord-007385-xcx4ic0s 36 5 sero sero NN cord-007385-xcx4ic0s 36 6 - - HYPH cord-007385-xcx4ic0s 36 7 neutralizing neutralize VBG cord-007385-xcx4ic0s 36 8 antibody antibody NN cord-007385-xcx4ic0s 36 9 response response NN cord-007385-xcx4ic0s 36 10 ( ( -LRB- cord-007385-xcx4ic0s 36 11 p p NN cord-007385-xcx4ic0s 36 12 < < XX cord-007385-xcx4ic0s 36 13 0.05 0.05 CD cord-007385-xcx4ic0s 36 14 ) ) -RRB- cord-007385-xcx4ic0s 36 15 and and CC cord-007385-xcx4ic0s 36 16 are be VBP cord-007385-xcx4ic0s 36 17 associated associate VBN cord-007385-xcx4ic0s 36 18 with with IN cord-007385-xcx4ic0s 36 19 increased increase VBN cord-007385-xcx4ic0s 36 20 nasal nasal NN cord-007385-xcx4ic0s 36 21 symptoms symptom NNS cord-007385-xcx4ic0s 36 22 and and CC cord-007385-xcx4ic0s 36 23 signs sign NNS cord-007385-xcx4ic0s 36 24 . . . cord-007385-xcx4ic0s 37 1 There there EX cord-007385-xcx4ic0s 37 2 is be VBZ cord-007385-xcx4ic0s 37 3 a a DT cord-007385-xcx4ic0s 37 4 trend trend NN cord-007385-xcx4ic0s 37 5 towards towards IN cord-007385-xcx4ic0s 37 6 longer long JJR cord-007385-xcx4ic0s 37 7 duration duration NN cord-007385-xcx4ic0s 37 8 of of IN cord-007385-xcx4ic0s 37 9 virus virus NN cord-007385-xcx4ic0s 37 10 shedding shed VBG cord-007385-xcx4ic0s 37 11 with with IN cord-007385-xcx4ic0s 37 12 both both DT cord-007385-xcx4ic0s 37 13 of of IN cord-007385-xcx4ic0s 37 14 these these DT cord-007385-xcx4ic0s 37 15 medications medication NNS cord-007385-xcx4ic0s 37 16 . . . cord-007385-xcx4ic0s 38 1 7 7 CD cord-007385-xcx4ic0s 38 2 Common common JJ cord-007385-xcx4ic0s 38 3 cold cold JJ cord-007385-xcx4ic0s 38 4 viruses virus NNS cord-007385-xcx4ic0s 38 5 characteristically characteristically RB cord-007385-xcx4ic0s 38 6 cause cause VBP cord-007385-xcx4ic0s 38 7 an an DT cord-007385-xcx4ic0s 38 8 infection infection NN cord-007385-xcx4ic0s 38 9 that that WDT cord-007385-xcx4ic0s 38 10 is be VBZ cord-007385-xcx4ic0s 38 11 self self NN cord-007385-xcx4ic0s 38 12 - - HYPH cord-007385-xcx4ic0s 38 13 limited limit VBN cord-007385-xcx4ic0s 38 14 and and CC cord-007385-xcx4ic0s 38 15 of of IN cord-007385-xcx4ic0s 38 16 short short JJ cord-007385-xcx4ic0s 38 17 duration duration NN cord-007385-xcx4ic0s 38 18 . . . cord-007385-xcx4ic0s 39 1 Although although IN cord-007385-xcx4ic0s 39 2 shedding shed VBG cord-007385-xcx4ic0s 39 3 of of IN cord-007385-xcx4ic0s 39 4 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 39 5 has have VBZ cord-007385-xcx4ic0s 39 6 been be VBN cord-007385-xcx4ic0s 39 7 shown show VBN cord-007385-xcx4ic0s 39 8 to to TO cord-007385-xcx4ic0s 39 9 last last JJ cord-007385-xcx4ic0s 39 10 3 3 CD cord-007385-xcx4ic0s 39 11 weeks week NNS cord-007385-xcx4ic0s 39 12 in in IN cord-007385-xcx4ic0s 39 13 young young JJ cord-007385-xcx4ic0s 39 14 adults adult NNS cord-007385-xcx4ic0s 39 15 with with IN cord-007385-xcx4ic0s 39 16 experimentally experimentally RB cord-007385-xcx4ic0s 39 17 induced induce VBN cord-007385-xcx4ic0s 39 18 colds cold NNS cord-007385-xcx4ic0s 39 19 , , , cord-007385-xcx4ic0s 39 20 s s NN cord-007385-xcx4ic0s 39 21 , , , cord-007385-xcx4ic0s 39 22 9 9 CD cord-007385-xcx4ic0s 39 23 rhinoinfections rhinoinfection NNS cord-007385-xcx4ic0s 39 24 with with IN cord-007385-xcx4ic0s 39 25 coronavirus coronavirus NN cord-007385-xcx4ic0s 39 26 are be VBP cord-007385-xcx4ic0s 39 27 usually usually RB cord-007385-xcx4ic0s 39 28 detected detect VBN cord-007385-xcx4ic0s 39 29 for for IN cord-007385-xcx4ic0s 39 30 only only RB cord-007385-xcx4ic0s 39 31 a a DT cord-007385-xcx4ic0s 39 32 few few JJ cord-007385-xcx4ic0s 39 33 days day NNS cord-007385-xcx4ic0s 39 34 . . . cord-007385-xcx4ic0s 40 1 Most Most JJS cord-007385-xcx4ic0s 40 2 colds cold NNS cord-007385-xcx4ic0s 40 3 are be VBP cord-007385-xcx4ic0s 40 4 not not RB cord-007385-xcx4ic0s 40 5 associated associate VBN cord-007385-xcx4ic0s 40 6 with with IN cord-007385-xcx4ic0s 40 7 cell cell NN cord-007385-xcx4ic0s 40 8 necrosis necrosis NN cord-007385-xcx4ic0s 40 9 or or CC cord-007385-xcx4ic0s 40 10 significant significant JJ cord-007385-xcx4ic0s 40 11 mucosal mucosal JJ cord-007385-xcx4ic0s 40 12 damage damage NN cord-007385-xcx4ic0s 40 13 , , , cord-007385-xcx4ic0s 40 14 but but CC cord-007385-xcx4ic0s 40 15 there there EX cord-007385-xcx4ic0s 40 16 may may MD cord-007385-xcx4ic0s 40 17 be be VB cord-007385-xcx4ic0s 40 18 some some DT cord-007385-xcx4ic0s 40 19 sloughing sloughing NN cord-007385-xcx4ic0s 40 20 of of IN cord-007385-xcx4ic0s 40 21 columnar columnar JJ cord-007385-xcx4ic0s 40 22 epithelial epithelial JJ cord-007385-xcx4ic0s 40 23 cells cell NNS cord-007385-xcx4ic0s 40 24 . . . cord-007385-xcx4ic0s 41 1 1 1 CD cord-007385-xcx4ic0s 41 2 ° ° NN cord-007385-xcx4ic0s 41 3 Initially initially RB cord-007385-xcx4ic0s 41 4 there there EX cord-007385-xcx4ic0s 41 5 is be VBZ cord-007385-xcx4ic0s 41 6 an an DT cord-007385-xcx4ic0s 41 7 increase increase NN cord-007385-xcx4ic0s 41 8 in in IN cord-007385-xcx4ic0s 41 9 vascular vascular JJ cord-007385-xcx4ic0s 41 10 permeability permeability NN cord-007385-xcx4ic0s 41 11 , , , cord-007385-xcx4ic0s 41 12 ~1 ~1 NNP cord-007385-xcx4ic0s 41 13 followed follow VBD cord-007385-xcx4ic0s 41 14 later later RB cord-007385-xcx4ic0s 41 15 by by IN cord-007385-xcx4ic0s 41 16 glandular glandular JJ cord-007385-xcx4ic0s 41 17 secretions secretion NNS cord-007385-xcx4ic0s 41 18 , , , cord-007385-xcx4ic0s 41 19 both both DT cord-007385-xcx4ic0s 41 20 of of IN cord-007385-xcx4ic0s 41 21 which which WDT cord-007385-xcx4ic0s 41 22 may may MD cord-007385-xcx4ic0s 41 23 have have VB cord-007385-xcx4ic0s 41 24 implications implication NNS cord-007385-xcx4ic0s 41 25 with with IN cord-007385-xcx4ic0s 41 26 regard regard NN cord-007385-xcx4ic0s 41 27 to to IN cord-007385-xcx4ic0s 41 28 the the DT cord-007385-xcx4ic0s 41 29 timing timing NN cord-007385-xcx4ic0s 41 30 and and CC cord-007385-xcx4ic0s 41 31 effectiveness effectiveness NN cord-007385-xcx4ic0s 41 32 of of IN cord-007385-xcx4ic0s 41 33 treatment treatment NN cord-007385-xcx4ic0s 41 34 . . . cord-007385-xcx4ic0s 42 1 The the DT cord-007385-xcx4ic0s 42 2 constituents constituent NNS cord-007385-xcx4ic0s 42 3 of of IN cord-007385-xcx4ic0s 42 4 the the DT cord-007385-xcx4ic0s 42 5 glandular glandular JJ cord-007385-xcx4ic0s 42 6 secretions secretion NNS cord-007385-xcx4ic0s 42 7 provide provide VBP cord-007385-xcx4ic0s 42 8 clues clue NNS cord-007385-xcx4ic0s 42 9 to to IN cord-007385-xcx4ic0s 42 10 their -PRON- PRP$ cord-007385-xcx4ic0s 42 11 origins origin NNS cord-007385-xcx4ic0s 42 12 . . . cord-007385-xcx4ic0s 43 1 11 11 CD cord-007385-xcx4ic0s 43 2 , , , cord-007385-xcx4ic0s 43 3 i2 i2 NNP cord-007385-xcx4ic0s 43 4 There there EX cord-007385-xcx4ic0s 43 5 is be VBZ cord-007385-xcx4ic0s 43 6 an an DT cord-007385-xcx4ic0s 43 7 elaboration elaboration NN cord-007385-xcx4ic0s 43 8 of of IN cord-007385-xcx4ic0s 43 9 inflammatory inflammatory JJ cord-007385-xcx4ic0s 43 10 mediators mediator NNS cord-007385-xcx4ic0s 43 11 such such JJ cord-007385-xcx4ic0s 43 12 as as IN cord-007385-xcx4ic0s 43 13 kinins kinin NNS cord-007385-xcx4ic0s 43 14 . . . cord-007385-xcx4ic0s 44 1 When when WRB cord-007385-xcx4ic0s 44 2 these these DT cord-007385-xcx4ic0s 44 3 mediators mediator NNS cord-007385-xcx4ic0s 44 4 accumulate accumulate VBP cord-007385-xcx4ic0s 44 5 along along RP cord-007385-xcx4ic0s 44 6 with with IN cord-007385-xcx4ic0s 44 7 polymorphonuclear polymorphonuclear JJ cord-007385-xcx4ic0s 44 8 cells cell NNS cord-007385-xcx4ic0s 44 9 , , , cord-007385-xcx4ic0s 44 10 there there EX cord-007385-xcx4ic0s 44 11 is be VBZ cord-007385-xcx4ic0s 44 12 an an DT cord-007385-xcx4ic0s 44 13 increase increase NN cord-007385-xcx4ic0s 44 14 in in IN cord-007385-xcx4ic0s 44 15 nasal nasal NN cord-007385-xcx4ic0s 44 16 symptoms symptom NNS cord-007385-xcx4ic0s 44 17 . . . cord-007385-xcx4ic0s 45 1 13 13 CD cord-007385-xcx4ic0s 46 1 Since since IN cord-007385-xcx4ic0s 46 2 bradykinin bradykinin NN cord-007385-xcx4ic0s 46 3 is be VBZ cord-007385-xcx4ic0s 46 4 a a DT cord-007385-xcx4ic0s 46 5 likely likely JJ cord-007385-xcx4ic0s 46 6 mediator mediator NN cord-007385-xcx4ic0s 46 7 , , , cord-007385-xcx4ic0s 46 8 14 14 CD cord-007385-xcx4ic0s 46 9 ( ( -LRB- cord-007385-xcx4ic0s 46 10 Table Table NNP cord-007385-xcx4ic0s 46 11 II II NNP cord-007385-xcx4ic0s 46 12 ) ) -RRB- cord-007385-xcx4ic0s 46 13 . . . cord-007385-xcx4ic0s 47 1 Although although IN cord-007385-xcx4ic0s 47 2 Doyle Doyle NNP cord-007385-xcx4ic0s 47 3 et et NNP cord-007385-xcx4ic0s 47 4 al al NNP cord-007385-xcx4ic0s 47 5 . . . cord-007385-xcx4ic0s 48 1 24 24 CD cord-007385-xcx4ic0s 48 2 reported report VBD cord-007385-xcx4ic0s 48 3 no no DT cord-007385-xcx4ic0s 48 4 increase increase NN cord-007385-xcx4ic0s 48 5 in in IN cord-007385-xcx4ic0s 48 6 nasal nasal JJ cord-007385-xcx4ic0s 48 7 responsiveness responsiveness NN cord-007385-xcx4ic0s 48 8 to to IN cord-007385-xcx4ic0s 48 9 an an DT cord-007385-xcx4ic0s 48 10 infectious infectious JJ cord-007385-xcx4ic0s 48 11 trigger trigger NN cord-007385-xcx4ic0s 48 12 in in IN cord-007385-xcx4ic0s 48 13 allergic allergic JJ cord-007385-xcx4ic0s 48 14 compared compare VBN cord-007385-xcx4ic0s 48 15 with with IN cord-007385-xcx4ic0s 48 16 nonallergic nonallergic JJ cord-007385-xcx4ic0s 48 17 individuals individual NNS cord-007385-xcx4ic0s 48 18 , , , cord-007385-xcx4ic0s 48 19 Bardin Bardin NNP cord-007385-xcx4ic0s 48 20 et et NNP cord-007385-xcx4ic0s 48 21 al al NNP cord-007385-xcx4ic0s 48 22 . . . cord-007385-xcx4ic0s 49 1 25 25 CD cord-007385-xcx4ic0s 49 2 found find VBD cord-007385-xcx4ic0s 49 3 that that IN cord-007385-xcx4ic0s 49 4 patients patient NNS cord-007385-xcx4ic0s 49 5 with with IN cord-007385-xcx4ic0s 49 6 allergic allergic JJ cord-007385-xcx4ic0s 49 7 rhinitis rhinitis NN cord-007385-xcx4ic0s 49 8 had have VBD cord-007385-xcx4ic0s 49 9 more more JJR cord-007385-xcx4ic0s 49 10 severe severe JJ cord-007385-xcx4ic0s 49 11 colds cold NNS cord-007385-xcx4ic0s 49 12 independent independent JJ cord-007385-xcx4ic0s 49 13 of of IN cord-007385-xcx4ic0s 49 14 preinnoculation preinnoculation NN cord-007385-xcx4ic0s 49 15 anti anti JJ cord-007385-xcx4ic0s 49 16 - - JJ cord-007385-xcx4ic0s 49 17 body body NN cord-007385-xcx4ic0s 49 18 . . . cord-007385-xcx4ic0s 50 1 There there EX cord-007385-xcx4ic0s 50 2 is be VBZ cord-007385-xcx4ic0s 50 3 also also RB cord-007385-xcx4ic0s 50 4 an an DT cord-007385-xcx4ic0s 50 5 increased increase VBN cord-007385-xcx4ic0s 50 6 twitchiness twitchiness NN cord-007385-xcx4ic0s 50 7 of of IN cord-007385-xcx4ic0s 50 8 the the DT cord-007385-xcx4ic0s 50 9 tracheal tracheal JJ cord-007385-xcx4ic0s 50 10 bronchial bronchial JJ cord-007385-xcx4ic0s 50 11 tree tree NN cord-007385-xcx4ic0s 50 12 following follow VBG cord-007385-xcx4ic0s 50 13 colds cold NNS cord-007385-xcx4ic0s 50 14 . . . cord-007385-xcx4ic0s 51 1 26 26 CD cord-007385-xcx4ic0s 52 1 Sir Sir NNP cord-007385-xcx4ic0s 52 2 William William NNP cord-007385-xcx4ic0s 52 3 Osler Osler NNP cord-007385-xcx4ic0s 52 4 has have VBZ cord-007385-xcx4ic0s 52 5 been be VBN cord-007385-xcx4ic0s 52 6 quoted quote VBN cord-007385-xcx4ic0s 52 7 as as IN cord-007385-xcx4ic0s 52 8 saying say VBG cord-007385-xcx4ic0s 52 9 , , , cord-007385-xcx4ic0s 52 10 " " `` cord-007385-xcx4ic0s 52 11 There there EX cord-007385-xcx4ic0s 52 12 is be VBZ cord-007385-xcx4ic0s 52 13 just just RB cord-007385-xcx4ic0s 52 14 one one CD cord-007385-xcx4ic0s 52 15 way way NN cord-007385-xcx4ic0s 52 16 to to TO cord-007385-xcx4ic0s 52 17 treat treat VB cord-007385-xcx4ic0s 52 18 a a DT cord-007385-xcx4ic0s 52 19 cold cold NN cord-007385-xcx4ic0s 52 20 , , , cord-007385-xcx4ic0s 52 21 i.e. i.e. FW cord-007385-xcx4ic0s 52 22 , , , cord-007385-xcx4ic0s 52 23 with with IN cord-007385-xcx4ic0s 52 24 contempt contempt NN cord-007385-xcx4ic0s 52 25 . . . cord-007385-xcx4ic0s 53 1 " " `` cord-007385-xcx4ic0s 53 2 We -PRON- PRP cord-007385-xcx4ic0s 53 3 seem seem VBP cord-007385-xcx4ic0s 53 4 to to TO cord-007385-xcx4ic0s 53 5 have have VB cord-007385-xcx4ic0s 53 6 made make VBN cord-007385-xcx4ic0s 53 7 some some DT cord-007385-xcx4ic0s 53 8 progress progress NN cord-007385-xcx4ic0s 53 9 in in IN cord-007385-xcx4ic0s 53 10 the the DT cord-007385-xcx4ic0s 53 11 treatment treatment NN cord-007385-xcx4ic0s 53 12 of of IN cord-007385-xcx4ic0s 53 13 URIs uri NNS cord-007385-xcx4ic0s 53 14 since since IN cord-007385-xcx4ic0s 53 15 this this DT cord-007385-xcx4ic0s 53 16 statement statement NN cord-007385-xcx4ic0s 53 17 was be VBD cord-007385-xcx4ic0s 53 18 made make VBN cord-007385-xcx4ic0s 53 19 , , , cord-007385-xcx4ic0s 53 20 due due JJ cord-007385-xcx4ic0s 53 21 largely largely RB cord-007385-xcx4ic0s 53 22 to to IN cord-007385-xcx4ic0s 53 23 a a DT cord-007385-xcx4ic0s 53 24 better well JJR cord-007385-xcx4ic0s 53 25 understanding understanding NN cord-007385-xcx4ic0s 53 26 of of IN cord-007385-xcx4ic0s 53 27 the the DT cord-007385-xcx4ic0s 53 28 pathophysiology pathophysiology NN cord-007385-xcx4ic0s 53 29 of of IN cord-007385-xcx4ic0s 53 30 colds cold NNS cord-007385-xcx4ic0s 53 31 , , , cord-007385-xcx4ic0s 53 32 although although IN cord-007385-xcx4ic0s 53 33 there there EX cord-007385-xcx4ic0s 53 34 is be VBZ cord-007385-xcx4ic0s 53 35 certainly certainly RB cord-007385-xcx4ic0s 53 36 still still RB cord-007385-xcx4ic0s 53 37 room room NN cord-007385-xcx4ic0s 53 38 for for IN cord-007385-xcx4ic0s 53 39 improvement improvement NN cord-007385-xcx4ic0s 53 40 . . . cord-007385-xcx4ic0s 54 1 Some some DT cord-007385-xcx4ic0s 54 2 treatments treatment NNS cord-007385-xcx4ic0s 54 3 used use VBN cord-007385-xcx4ic0s 54 4 today today NN cord-007385-xcx4ic0s 54 5 are be VBP cord-007385-xcx4ic0s 54 6 better well JJR cord-007385-xcx4ic0s 54 7 choices choice NNS cord-007385-xcx4ic0s 54 8 than than IN cord-007385-xcx4ic0s 54 9 others other NNS cord-007385-xcx4ic0s 54 10 in in IN cord-007385-xcx4ic0s 54 11 terms term NNS cord-007385-xcx4ic0s 54 12 of of IN cord-007385-xcx4ic0s 54 13 pathophysiology pathophysiology NN cord-007385-xcx4ic0s 54 14 . . . cord-007385-xcx4ic0s 55 1 As as IN cord-007385-xcx4ic0s 55 2 mentioned mention VBN cord-007385-xcx4ic0s 55 3 previously previously RB cord-007385-xcx4ic0s 55 4 , , , cord-007385-xcx4ic0s 55 5 both both CC cord-007385-xcx4ic0s 55 6 aspirin aspirin NN cord-007385-xcx4ic0s 55 7 and and CC cord-007385-xcx4ic0s 55 8 acetaminophen acetaminophen NN cord-007385-xcx4ic0s 55 9 may may MD cord-007385-xcx4ic0s 55 10 have have VB cord-007385-xcx4ic0s 55 11 a a DT cord-007385-xcx4ic0s 55 12 detrimental detrimental JJ cord-007385-xcx4ic0s 55 13 effect effect NN cord-007385-xcx4ic0s 55 14 on on IN cord-007385-xcx4ic0s 55 15 cold cold JJ cord-007385-xcx4ic0s 55 16 treatment treatment NN cord-007385-xcx4ic0s 55 17 , , , cord-007385-xcx4ic0s 55 18 neutralizing neutralize VBG cord-007385-xcx4ic0s 55 19 antibodies antibody NNS cord-007385-xcx4ic0s 55 20 and and CC cord-007385-xcx4ic0s 55 21 increasing increase VBG cord-007385-xcx4ic0s 55 22 nasal nasal NN cord-007385-xcx4ic0s 55 23 symptoms symptom NNS cord-007385-xcx4ic0s 55 24 . . . cord-007385-xcx4ic0s 56 1 27 27 CD cord-007385-xcx4ic0s 57 1 In in IN cord-007385-xcx4ic0s 57 2 a a DT cord-007385-xcx4ic0s 57 3 1136 1136 CD cord-007385-xcx4ic0s 57 4 Spector Spector NNP cord-007385-xcx4ic0s 57 5 J J NNP cord-007385-xcx4ic0s 57 6 ALLERGY ALLERGY NNP cord-007385-xcx4ic0s 57 7 CLIN CLIN NNP cord-007385-xcx4ic0s 57 8 IMMUNOL IMMUNOL NNP cord-007385-xcx4ic0s 57 9 MAY MAY NNP cord-007385-xcx4ic0s 57 10 1995 1995 CD cord-007385-xcx4ic0s 57 11 study study NN cord-007385-xcx4ic0s 57 12 by by IN cord-007385-xcx4ic0s 57 13 Sperber Sperber NNP cord-007385-xcx4ic0s 57 14 et et NNP cord-007385-xcx4ic0s 57 15 al al NNP cord-007385-xcx4ic0s 57 16 . . . cord-007385-xcx4ic0s 58 1 , , , cord-007385-xcx4ic0s 59 1 28 28 CD cord-007385-xcx4ic0s 60 1 naproxen naproxen NNP cord-007385-xcx4ic0s 60 2 did do VBD cord-007385-xcx4ic0s 60 3 not not RB cord-007385-xcx4ic0s 60 4 alter alter VB cord-007385-xcx4ic0s 60 5 virus virus NN cord-007385-xcx4ic0s 60 6 shedding shed VBG cord-007385-xcx4ic0s 60 7 or or CC cord-007385-xcx4ic0s 60 8 serum serum NN cord-007385-xcx4ic0s 60 9 neutralizing neutralize VBG cord-007385-xcx4ic0s 60 10 antibody antibody NN cord-007385-xcx4ic0s 60 11 in in IN cord-007385-xcx4ic0s 60 12 experimental experimental JJ cord-007385-xcx4ic0s 60 13 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 60 14 cold cold NN cord-007385-xcx4ic0s 60 15 , , , cord-007385-xcx4ic0s 60 16 but but CC cord-007385-xcx4ic0s 60 17 it -PRON- PRP cord-007385-xcx4ic0s 60 18 had have VBD cord-007385-xcx4ic0s 60 19 a a DT cord-007385-xcx4ic0s 60 20 beneficial beneficial JJ cord-007385-xcx4ic0s 60 21 effect effect NN cord-007385-xcx4ic0s 60 22 on on IN cord-007385-xcx4ic0s 60 23 such such JJ cord-007385-xcx4ic0s 60 24 symptoms symptom NNS cord-007385-xcx4ic0s 60 25 as as IN cord-007385-xcx4ic0s 60 26 headache headache NN cord-007385-xcx4ic0s 60 27 , , , cord-007385-xcx4ic0s 60 28 malaise malaise NN cord-007385-xcx4ic0s 60 29 , , , cord-007385-xcx4ic0s 60 30 myalgia myalgia NN cord-007385-xcx4ic0s 60 31 , , , cord-007385-xcx4ic0s 60 32 and and CC cord-007385-xcx4ic0s 60 33 cough cough NN cord-007385-xcx4ic0s 60 34 . . . cord-007385-xcx4ic0s 61 1 Oral oral JJ cord-007385-xcx4ic0s 61 2 o~-agonists o~-agonist NNS cord-007385-xcx4ic0s 61 3 relieve relieve VBP cord-007385-xcx4ic0s 61 4 congestion congestion NN cord-007385-xcx4ic0s 61 5 in in IN cord-007385-xcx4ic0s 61 6 many many JJ cord-007385-xcx4ic0s 61 7 individuals individual NNS cord-007385-xcx4ic0s 61 8 , , , cord-007385-xcx4ic0s 61 9 although although IN cord-007385-xcx4ic0s 61 10 their -PRON- PRP$ cord-007385-xcx4ic0s 61 11 effect effect NN cord-007385-xcx4ic0s 61 12 is be VBZ cord-007385-xcx4ic0s 61 13 not not RB cord-007385-xcx4ic0s 61 14 dramatic dramatic JJ cord-007385-xcx4ic0s 61 15 . . . cord-007385-xcx4ic0s 62 1 29 29 CD cord-007385-xcx4ic0s 62 2 , , , cord-007385-xcx4ic0s 62 3 3o 3o CD cord-007385-xcx4ic0s 62 4 Topical topical JJ cord-007385-xcx4ic0s 62 5 decongestants decongestant NNS cord-007385-xcx4ic0s 62 6 may may MD cord-007385-xcx4ic0s 62 7 also also RB cord-007385-xcx4ic0s 62 8 help help VB cord-007385-xcx4ic0s 62 9 ; ; : cord-007385-xcx4ic0s 62 10 unfortunately unfortunately RB cord-007385-xcx4ic0s 62 11 , , , cord-007385-xcx4ic0s 62 12 if if IN cord-007385-xcx4ic0s 62 13 they -PRON- PRP cord-007385-xcx4ic0s 62 14 are be VBP cord-007385-xcx4ic0s 62 15 overused overuse VBN cord-007385-xcx4ic0s 62 16 they -PRON- PRP cord-007385-xcx4ic0s 62 17 may may MD cord-007385-xcx4ic0s 62 18 also also RB cord-007385-xcx4ic0s 62 19 be be VB cord-007385-xcx4ic0s 62 20 associated associate VBN cord-007385-xcx4ic0s 62 21 with with IN cord-007385-xcx4ic0s 62 22 rebound rebound NN cord-007385-xcx4ic0s 62 23 congestion congestion NN cord-007385-xcx4ic0s 62 24 or or CC cord-007385-xcx4ic0s 62 25 worsening worsening NN cord-007385-xcx4ic0s 62 26 of of IN cord-007385-xcx4ic0s 62 27 symptoms symptom NNS cord-007385-xcx4ic0s 62 28 . . . cord-007385-xcx4ic0s 63 1 The the DT cord-007385-xcx4ic0s 63 2 role role NN cord-007385-xcx4ic0s 63 3 of of IN cord-007385-xcx4ic0s 63 4 antihistamines antihistamine NNS cord-007385-xcx4ic0s 63 5 in in IN cord-007385-xcx4ic0s 63 6 the the DT cord-007385-xcx4ic0s 63 7 treatment treatment NN cord-007385-xcx4ic0s 63 8 of of IN cord-007385-xcx4ic0s 63 9 the the DT cord-007385-xcx4ic0s 63 10 common common JJ cord-007385-xcx4ic0s 63 11 cold cold NN cord-007385-xcx4ic0s 63 12 has have VBZ cord-007385-xcx4ic0s 63 13 been be VBN cord-007385-xcx4ic0s 63 14 debated debate VBN cord-007385-xcx4ic0s 63 15 . . . cord-007385-xcx4ic0s 64 1 Some some DT cord-007385-xcx4ic0s 64 2 antihistamines antihistamine NNS cord-007385-xcx4ic0s 64 3 do do VBP cord-007385-xcx4ic0s 64 4 not not RB cord-007385-xcx4ic0s 64 5 seem seem VB cord-007385-xcx4ic0s 64 6 to to TO cord-007385-xcx4ic0s 64 7 be be VB cord-007385-xcx4ic0s 64 8 very very RB cord-007385-xcx4ic0s 64 9 effective effective JJ cord-007385-xcx4ic0s 64 10 , , , cord-007385-xcx4ic0s 64 11 31 31 CD cord-007385-xcx4ic0s 64 12 whereas whereas IN cord-007385-xcx4ic0s 64 13 others other NNS cord-007385-xcx4ic0s 64 14 may may MD cord-007385-xcx4ic0s 64 15 provide provide VB cord-007385-xcx4ic0s 64 16 mild mild JJ cord-007385-xcx4ic0s 64 17 benefit benefit NN cord-007385-xcx4ic0s 64 18 . . . cord-007385-xcx4ic0s 65 1 Antihistamine/ antihistamine/ DT cord-007385-xcx4ic0s 65 2 decongestants decongestant NNS cord-007385-xcx4ic0s 65 3 do do VBP cord-007385-xcx4ic0s 65 4 not not RB cord-007385-xcx4ic0s 65 5 appear appear VB cord-007385-xcx4ic0s 65 6 to to TO cord-007385-xcx4ic0s 65 7 be be VB cord-007385-xcx4ic0s 65 8 effective effective JJ cord-007385-xcx4ic0s 65 9 in in IN cord-007385-xcx4ic0s 65 10 the the DT cord-007385-xcx4ic0s 65 11 treatment treatment NN cord-007385-xcx4ic0s 65 12 of of IN cord-007385-xcx4ic0s 65 13 URIs uri NNS cord-007385-xcx4ic0s 65 14 in in IN cord-007385-xcx4ic0s 65 15 children child NNS cord-007385-xcx4ic0s 65 16 . . . cord-007385-xcx4ic0s 66 1 32 32 CD cord-007385-xcx4ic0s 66 2 , , , cord-007385-xcx4ic0s 66 3 33 33 CD cord-007385-xcx4ic0s 66 4 Cromolyn Cromolyn NNP cord-007385-xcx4ic0s 66 5 sodium sodium NN cord-007385-xcx4ic0s 66 6 and and CC cord-007385-xcx4ic0s 66 7 nedocromil nedocromil NNP cord-007385-xcx4ic0s 66 8 have have VBP cord-007385-xcx4ic0s 66 9 both both DT cord-007385-xcx4ic0s 66 10 been be VBN cord-007385-xcx4ic0s 66 11 studied study VBN cord-007385-xcx4ic0s 66 12 ; ; : cord-007385-xcx4ic0s 66 13 they -PRON- PRP cord-007385-xcx4ic0s 66 14 do do VBP cord-007385-xcx4ic0s 66 15 not not RB cord-007385-xcx4ic0s 66 16 cause cause VB cord-007385-xcx4ic0s 66 17 a a DT cord-007385-xcx4ic0s 66 18 worsening worsening NN cord-007385-xcx4ic0s 66 19 of of IN cord-007385-xcx4ic0s 66 20 symptoms symptom NNS cord-007385-xcx4ic0s 66 21 , , , cord-007385-xcx4ic0s 66 22 but but CC cord-007385-xcx4ic0s 66 23 neither neither DT cord-007385-xcx4ic0s 66 24 do do VBP cord-007385-xcx4ic0s 66 25 they -PRON- PRP cord-007385-xcx4ic0s 66 26 seem seem VB cord-007385-xcx4ic0s 66 27 to to TO cord-007385-xcx4ic0s 66 28 provide provide VB cord-007385-xcx4ic0s 66 29 any any DT cord-007385-xcx4ic0s 66 30 significant significant JJ cord-007385-xcx4ic0s 66 31 improvement improvement NN cord-007385-xcx4ic0s 66 32 . . . cord-007385-xcx4ic0s 67 1 34 34 CD cord-007385-xcx4ic0s 67 2 , , , cord-007385-xcx4ic0s 67 3 35 35 CD cord-007385-xcx4ic0s 67 4 Apparently apparently RB cord-007385-xcx4ic0s 67 5 menthol menthol NN cord-007385-xcx4ic0s 67 6 can can MD cord-007385-xcx4ic0s 67 7 not not RB cord-007385-xcx4ic0s 67 8 be be VB cord-007385-xcx4ic0s 67 9 positively positively RB cord-007385-xcx4ic0s 67 10 demonstrated demonstrate VBN cord-007385-xcx4ic0s 67 11 to to TO cord-007385-xcx4ic0s 67 12 provide provide VB cord-007385-xcx4ic0s 67 13 a a DT cord-007385-xcx4ic0s 67 14 beneficial beneficial JJ cord-007385-xcx4ic0s 67 15 effect effect NN cord-007385-xcx4ic0s 67 16 ? ? . cord-007385-xcx4ic0s 68 1 6 6 CD cord-007385-xcx4ic0s 69 1 Interferon Interferon NNP cord-007385-xcx4ic0s 69 2 has have VBZ cord-007385-xcx4ic0s 69 3 been be VBN cord-007385-xcx4ic0s 69 4 used use VBN cord-007385-xcx4ic0s 69 5 in in IN cord-007385-xcx4ic0s 69 6 various various JJ cord-007385-xcx4ic0s 69 7 studies study NNS cord-007385-xcx4ic0s 69 8 with with IN cord-007385-xcx4ic0s 69 9 negative negative JJ cord-007385-xcx4ic0s 69 10 results result NNS cord-007385-xcx4ic0s 69 11 . . . cord-007385-xcx4ic0s 70 1 3739 3739 CD cord-007385-xcx4ic0s 71 1 Either either CC cord-007385-xcx4ic0s 71 2 intranasal intranasal JJ cord-007385-xcx4ic0s 71 3 or or CC cord-007385-xcx4ic0s 71 4 systemic systemic JJ cord-007385-xcx4ic0s 71 5 steroids steroid NNS cord-007385-xcx4ic0s 71 6 may may MD cord-007385-xcx4ic0s 71 7 suppress suppress VB cord-007385-xcx4ic0s 71 8 inflammation inflammation NN cord-007385-xcx4ic0s 71 9 during during IN cord-007385-xcx4ic0s 71 10 the the DT cord-007385-xcx4ic0s 71 11 first first JJ cord-007385-xcx4ic0s 71 12 days day NNS cord-007385-xcx4ic0s 71 13 of of IN cord-007385-xcx4ic0s 71 14 infection infection NN cord-007385-xcx4ic0s 71 15 , , , cord-007385-xcx4ic0s 71 16 and and CC cord-007385-xcx4ic0s 71 17 would would MD cord-007385-xcx4ic0s 71 18 seem seem VB cord-007385-xcx4ic0s 71 19 to to TO cord-007385-xcx4ic0s 71 20 merit merit VB cord-007385-xcx4ic0s 71 21 further further JJ cord-007385-xcx4ic0s 71 22 investigation investigation NN cord-007385-xcx4ic0s 71 23 . . . cord-007385-xcx4ic0s 72 1 4 4 LS cord-007385-xcx4ic0s 72 2 ° ° NNS cord-007385-xcx4ic0s 72 3 Among among IN cord-007385-xcx4ic0s 72 4 the the DT cord-007385-xcx4ic0s 72 5 many many JJ cord-007385-xcx4ic0s 72 6 nonpharmacologic nonpharmacologic JJ cord-007385-xcx4ic0s 72 7 therapies therapy NNS cord-007385-xcx4ic0s 72 8 , , , cord-007385-xcx4ic0s 72 9 steam steam NN cord-007385-xcx4ic0s 72 10 has have VBZ cord-007385-xcx4ic0s 72 11 been be VBN cord-007385-xcx4ic0s 72 12 shown show VBN cord-007385-xcx4ic0s 72 13 by by IN cord-007385-xcx4ic0s 72 14 various various JJ cord-007385-xcx4ic0s 72 15 authors author NNS cord-007385-xcx4ic0s 72 16 to to TO cord-007385-xcx4ic0s 72 17 provide provide VB cord-007385-xcx4ic0s 72 18 no no DT cord-007385-xcx4ic0s 72 19 beneficial beneficial JJ cord-007385-xcx4ic0s 72 20 effect effect NN cord-007385-xcx4ic0s 72 21 ; ; : cord-007385-xcx4ic0s 72 22 41 41 CD cord-007385-xcx4ic0s 72 23 , , , cord-007385-xcx4ic0s 72 24 42 42 CD cord-007385-xcx4ic0s 72 25 however however RB cord-007385-xcx4ic0s 72 26 , , , cord-007385-xcx4ic0s 72 27 with with IN cord-007385-xcx4ic0s 72 28 proper proper JJ cord-007385-xcx4ic0s 72 29 timing timing NN cord-007385-xcx4ic0s 72 30 , , , cord-007385-xcx4ic0s 72 31 local local JJ cord-007385-xcx4ic0s 72 32 hyperthermia hyperthermia NN cord-007385-xcx4ic0s 72 33 43 43 CD cord-007385-xcx4ic0s 72 34 or or CC cord-007385-xcx4ic0s 72 35 sauna sauna NN cord-007385-xcx4ic0s 72 36 44 44 CD cord-007385-xcx4ic0s 72 37 may may MD cord-007385-xcx4ic0s 72 38 decrease decrease VB cord-007385-xcx4ic0s 72 39 the the DT cord-007385-xcx4ic0s 72 40 incidence incidence NN cord-007385-xcx4ic0s 72 41 of of IN cord-007385-xcx4ic0s 72 42 colds cold NNS cord-007385-xcx4ic0s 72 43 or or CC cord-007385-xcx4ic0s 72 44 provide provide VB cord-007385-xcx4ic0s 72 45 slight slight JJ cord-007385-xcx4ic0s 72 46 relief relief NN cord-007385-xcx4ic0s 72 47 . . . cord-007385-xcx4ic0s 73 1 In in IN cord-007385-xcx4ic0s 73 2 general general JJ cord-007385-xcx4ic0s 73 3 , , , cord-007385-xcx4ic0s 73 4 the the DT cord-007385-xcx4ic0s 73 5 use use NN cord-007385-xcx4ic0s 73 6 of of IN cord-007385-xcx4ic0s 73 7 zinc zinc NN cord-007385-xcx4ic0s 73 8 has have VBZ cord-007385-xcx4ic0s 73 9 been be VBN cord-007385-xcx4ic0s 73 10 disappointing disappointing JJ cord-007385-xcx4ic0s 73 11 and and CC cord-007385-xcx4ic0s 73 12 is be VBZ cord-007385-xcx4ic0s 73 13 associated associate VBN cord-007385-xcx4ic0s 73 14 with with IN cord-007385-xcx4ic0s 73 15 side side JJ cord-007385-xcx4ic0s 73 16 effects effect NNS cord-007385-xcx4ic0s 73 17 . . . cord-007385-xcx4ic0s 74 1 45 45 CD cord-007385-xcx4ic0s 74 2 Godfrey Godfrey NNP cord-007385-xcx4ic0s 74 3 et et NNP cord-007385-xcx4ic0s 74 4 al al NNP cord-007385-xcx4ic0s 74 5 . . . cord-007385-xcx4ic0s 75 1 46 46 CD cord-007385-xcx4ic0s 75 2 commented comment VBD cord-007385-xcx4ic0s 75 3 on on IN cord-007385-xcx4ic0s 75 4 the the DT cord-007385-xcx4ic0s 75 5 poor poor JJ cord-007385-xcx4ic0s 75 6 bioavailability bioavailability NN cord-007385-xcx4ic0s 75 7 of of IN cord-007385-xcx4ic0s 75 8 the the DT cord-007385-xcx4ic0s 75 9 older old JJR cord-007385-xcx4ic0s 75 10 zinc zinc NN cord-007385-xcx4ic0s 75 11 products product NNS cord-007385-xcx4ic0s 75 12 and and CC cord-007385-xcx4ic0s 75 13 found find VBD cord-007385-xcx4ic0s 75 14 a a DT cord-007385-xcx4ic0s 75 15 statistically statistically RB cord-007385-xcx4ic0s 75 16 significant significant JJ cord-007385-xcx4ic0s 75 17 decrease decrease NN cord-007385-xcx4ic0s 75 18 in in IN cord-007385-xcx4ic0s 75 19 the the DT cord-007385-xcx4ic0s 75 20 duration duration NN cord-007385-xcx4ic0s 75 21 of of IN cord-007385-xcx4ic0s 75 22 colds cold NNS cord-007385-xcx4ic0s 75 23 with with IN cord-007385-xcx4ic0s 75 24 their -PRON- PRP$ cord-007385-xcx4ic0s 75 25 nonchelated nonchelated JJ cord-007385-xcx4ic0s 75 26 formulations formulation NNS cord-007385-xcx4ic0s 75 27 . . . cord-007385-xcx4ic0s 76 1 Vitamin vitamin NN cord-007385-xcx4ic0s 76 2 C c NN cord-007385-xcx4ic0s 76 3 may may MD cord-007385-xcx4ic0s 76 4 decrease decrease VB cord-007385-xcx4ic0s 76 5 the the DT cord-007385-xcx4ic0s 76 6 duration duration NN cord-007385-xcx4ic0s 76 7 of of IN cord-007385-xcx4ic0s 76 8 cold cold JJ cord-007385-xcx4ic0s 76 9 symptoms.47 symptoms.47 NNP cord-007385-xcx4ic0s 76 10 , , , cord-007385-xcx4ic0s 76 11 48 48 CD cord-007385-xcx4ic0s 76 12 Of of RB cord-007385-xcx4ic0s 76 13 course course RB cord-007385-xcx4ic0s 76 14 , , , cord-007385-xcx4ic0s 76 15 chicken chicken NN cord-007385-xcx4ic0s 76 16 soup soup NN cord-007385-xcx4ic0s 76 17 is be VBZ cord-007385-xcx4ic0s 76 18 well well RB cord-007385-xcx4ic0s 76 19 known known JJ cord-007385-xcx4ic0s 76 20 to to TO cord-007385-xcx4ic0s 76 21 provide provide VB cord-007385-xcx4ic0s 76 22 benefit benefit NN cord-007385-xcx4ic0s 76 23 in in IN cord-007385-xcx4ic0s 76 24 the the DT cord-007385-xcx4ic0s 76 25 common common JJ cord-007385-xcx4ic0s 76 26 cold cold NN cord-007385-xcx4ic0s 76 27 ( ( -LRB- cord-007385-xcx4ic0s 76 28 as as RB cord-007385-xcx4ic0s 76 29 long long RB cord-007385-xcx4ic0s 76 30 as as IN cord-007385-xcx4ic0s 76 31 it -PRON- PRP cord-007385-xcx4ic0s 76 32 is be VBZ cord-007385-xcx4ic0s 76 33 one one CD cord-007385-xcx4ic0s 76 34 's 's POS cord-007385-xcx4ic0s 76 35 mother mother NN cord-007385-xcx4ic0s 76 36 's 's POS cord-007385-xcx4ic0s 76 37 ) ) -RRB- cord-007385-xcx4ic0s 76 38 . . . cord-007385-xcx4ic0s 77 1 In in IN cord-007385-xcx4ic0s 77 2 answer answer NN cord-007385-xcx4ic0s 77 3 to to IN cord-007385-xcx4ic0s 77 4 the the DT cord-007385-xcx4ic0s 77 5 cynics cynic NNS cord-007385-xcx4ic0s 77 6 who who WP cord-007385-xcx4ic0s 77 7 doubt doubt VBP cord-007385-xcx4ic0s 77 8 such such PDT cord-007385-xcx4ic0s 77 9 an an DT cord-007385-xcx4ic0s 77 10 assertion assertion NN cord-007385-xcx4ic0s 77 11 , , , cord-007385-xcx4ic0s 77 12 chicken chicken NN cord-007385-xcx4ic0s 77 13 soup soup NN cord-007385-xcx4ic0s 77 14 has have VBZ cord-007385-xcx4ic0s 77 15 been be VBN cord-007385-xcx4ic0s 77 16 demonstrated demonstrate VBN cord-007385-xcx4ic0s 77 17 to to TO cord-007385-xcx4ic0s 77 18 improve improve VB cord-007385-xcx4ic0s 77 19 mucociliary mucociliary JJ cord-007385-xcx4ic0s 77 20 clearance clearance NN cord-007385-xcx4ic0s 77 21 . . . cord-007385-xcx4ic0s 78 1 49 49 CD cord-007385-xcx4ic0s 79 1 There there EX cord-007385-xcx4ic0s 79 2 are be VBP cord-007385-xcx4ic0s 79 3 new new JJ cord-007385-xcx4ic0s 79 4 pharmacologic pharmacologic JJ cord-007385-xcx4ic0s 79 5 therapies therapy NNS cord-007385-xcx4ic0s 79 6 on on IN cord-007385-xcx4ic0s 79 7 the the DT cord-007385-xcx4ic0s 79 8 horizon horizon NN cord-007385-xcx4ic0s 79 9 that that WDT cord-007385-xcx4ic0s 79 10 may may MD cord-007385-xcx4ic0s 79 11 prove prove VB cord-007385-xcx4ic0s 79 12 useful useful JJ cord-007385-xcx4ic0s 79 13 to to IN cord-007385-xcx4ic0s 79 14 the the DT cord-007385-xcx4ic0s 79 15 physician physician NN cord-007385-xcx4ic0s 79 16 in in IN cord-007385-xcx4ic0s 79 17 the the DT cord-007385-xcx4ic0s 79 18 treatment treatment NN cord-007385-xcx4ic0s 79 19 of of IN cord-007385-xcx4ic0s 79 20 the the DT cord-007385-xcx4ic0s 79 21 common common JJ cord-007385-xcx4ic0s 79 22 cold cold NN cord-007385-xcx4ic0s 79 23 . . . cord-007385-xcx4ic0s 80 1 Ipratropium ipratropium NN cord-007385-xcx4ic0s 80 2 bromide bromide NN cord-007385-xcx4ic0s 80 3 nasal nasal NN cord-007385-xcx4ic0s 80 4 spray spray NN cord-007385-xcx4ic0s 80 5 , , , cord-007385-xcx4ic0s 80 6 an an DT cord-007385-xcx4ic0s 80 7 anticholinergic anticholinergic JJ cord-007385-xcx4ic0s 80 8 therapy therapy NN cord-007385-xcx4ic0s 80 9 , , , cord-007385-xcx4ic0s 80 10 has have VBZ cord-007385-xcx4ic0s 80 11 the the DT cord-007385-xcx4ic0s 80 12 unique unique JJ cord-007385-xcx4ic0s 80 13 property property NN cord-007385-xcx4ic0s 80 14 of of IN cord-007385-xcx4ic0s 80 15 specifically specifically RB cord-007385-xcx4ic0s 80 16 controlling control VBG cord-007385-xcx4ic0s 80 17 rhinorrhea rhinorrhea NNP cord-007385-xcx4ic0s 80 18 in in IN cord-007385-xcx4ic0s 80 19 URIs URIs NNP cord-007385-xcx4ic0s 80 20 , , , cord-007385-xcx4ic0s 80 21 as as IN cord-007385-xcx4ic0s 80 22 has have VBZ cord-007385-xcx4ic0s 80 23 been be VBN cord-007385-xcx4ic0s 80 24 demonstrated demonstrate VBN cord-007385-xcx4ic0s 80 25 in in IN cord-007385-xcx4ic0s 80 26 many many JJ cord-007385-xcx4ic0s 80 27 studies9 studies9 NN cord-007385-xcx4ic0s 80 28 , , , cord-007385-xcx4ic0s 80 29 51 51 CD cord-007385-xcx4ic0s 81 1 A a DT cord-007385-xcx4ic0s 81 2 novel novel JJ cord-007385-xcx4ic0s 81 3 attempt attempt NN cord-007385-xcx4ic0s 81 4 at at IN cord-007385-xcx4ic0s 81 5 antiviral antiviral JJ cord-007385-xcx4ic0s 81 6 therapy therapy NN cord-007385-xcx4ic0s 81 7 includes include VBZ cord-007385-xcx4ic0s 81 8 blockade blockade NN cord-007385-xcx4ic0s 81 9 of of IN cord-007385-xcx4ic0s 81 10 the the DT cord-007385-xcx4ic0s 81 11 receptor receptor NN cord-007385-xcx4ic0s 81 12 where where WRB cord-007385-xcx4ic0s 81 13 the the DT cord-007385-xcx4ic0s 81 14 virus virus NN cord-007385-xcx4ic0s 81 15 attaches attach VBZ cord-007385-xcx4ic0s 81 16 . . . cord-007385-xcx4ic0s 82 1 52 52 CD cord-007385-xcx4ic0s 83 1 Such such PDT cord-007385-xcx4ic0s 83 2 a a DT cord-007385-xcx4ic0s 83 3 treatment treatment NN cord-007385-xcx4ic0s 83 4 may may MD cord-007385-xcx4ic0s 83 5 be be VB cord-007385-xcx4ic0s 83 6 useful useful JJ cord-007385-xcx4ic0s 83 7 against against IN cord-007385-xcx4ic0s 83 8 rhinoviruses rhinovirus NNS cord-007385-xcx4ic0s 83 9 that that WDT cord-007385-xcx4ic0s 83 10 affect affect VBP cord-007385-xcx4ic0s 83 11 one one CD cord-007385-xcx4ic0s 83 12 or or CC cord-007385-xcx4ic0s 83 13 two two CD cord-007385-xcx4ic0s 83 14 common common JJ cord-007385-xcx4ic0s 83 15 receptors receptor NNS cord-007385-xcx4ic0s 83 16 but but CC cord-007385-xcx4ic0s 83 17 may may MD cord-007385-xcx4ic0s 83 18 not not RB cord-007385-xcx4ic0s 83 19 be be VB cord-007385-xcx4ic0s 83 20 applicable applicable JJ cord-007385-xcx4ic0s 83 21 to to IN cord-007385-xcx4ic0s 83 22 less less RBR cord-007385-xcx4ic0s 83 23 specific specific JJ cord-007385-xcx4ic0s 83 24 viruses virus NNS cord-007385-xcx4ic0s 83 25 . . . cord-007385-xcx4ic0s 84 1 Modern modern JJ cord-007385-xcx4ic0s 84 2 research research NN cord-007385-xcx4ic0s 84 3 has have VBZ cord-007385-xcx4ic0s 84 4 demonstrated demonstrate VBN cord-007385-xcx4ic0s 84 5 that that IN cord-007385-xcx4ic0s 84 6 URIs uri NNS cord-007385-xcx4ic0s 84 7 have have VBP cord-007385-xcx4ic0s 84 8 myriad myriad JJ cord-007385-xcx4ic0s 84 9 causes cause NNS cord-007385-xcx4ic0s 84 10 and and CC cord-007385-xcx4ic0s 84 11 complex complex JJ cord-007385-xcx4ic0s 84 12 effects effect NNS cord-007385-xcx4ic0s 84 13 . . . cord-007385-xcx4ic0s 85 1 Although although IN cord-007385-xcx4ic0s 85 2 some some DT cord-007385-xcx4ic0s 85 3 time time NN cord-007385-xcx4ic0s 85 4 - - HYPH cord-007385-xcx4ic0s 85 5 honored honor VBN cord-007385-xcx4ic0s 85 6 treatments treatment NNS cord-007385-xcx4ic0s 85 7 might may MD cord-007385-xcx4ic0s 85 8 have have VB cord-007385-xcx4ic0s 85 9 limited limit VBN cord-007385-xcx4ic0s 85 10 usefulness usefulness NN cord-007385-xcx4ic0s 85 11 , , , cord-007385-xcx4ic0s 85 12 novel novel NN cord-007385-xcx4ic0s 85 13 attempts attempt NNS cord-007385-xcx4ic0s 85 14 at at IN cord-007385-xcx4ic0s 85 15 ameliorating ameliorate VBG cord-007385-xcx4ic0s 85 16 the the DT cord-007385-xcx4ic0s 85 17 symptoms symptom NNS cord-007385-xcx4ic0s 85 18 of of IN cord-007385-xcx4ic0s 85 19 a a DT cord-007385-xcx4ic0s 85 20 common common JJ cord-007385-xcx4ic0s 85 21 cold cold NN cord-007385-xcx4ic0s 85 22 , , , cord-007385-xcx4ic0s 85 23 such such JJ cord-007385-xcx4ic0s 85 24 as as IN cord-007385-xcx4ic0s 85 25 the the DT cord-007385-xcx4ic0s 85 26 use use NN cord-007385-xcx4ic0s 85 27 of of IN cord-007385-xcx4ic0s 85 28 ipratropium ipratropium NN cord-007385-xcx4ic0s 85 29 bromide bromide NN cord-007385-xcx4ic0s 85 30 nasal nasal NN cord-007385-xcx4ic0s 85 31 spray spray NN cord-007385-xcx4ic0s 85 32 or or CC cord-007385-xcx4ic0s 85 33 specific specific JJ cord-007385-xcx4ic0s 85 34 antiviral antiviral JJ cord-007385-xcx4ic0s 85 35 receptor receptor NN cord-007385-xcx4ic0s 85 36 therapy therapy NN cord-007385-xcx4ic0s 85 37 , , , cord-007385-xcx4ic0s 85 38 might may MD cord-007385-xcx4ic0s 85 39 represent represent VB cord-007385-xcx4ic0s 85 40 a a DT cord-007385-xcx4ic0s 85 41 significant significant JJ cord-007385-xcx4ic0s 85 42 advance advance NN cord-007385-xcx4ic0s 85 43 . . . cord-007385-xcx4ic0s 86 1 They -PRON- PRP cord-007385-xcx4ic0s 86 2 are be VBP cord-007385-xcx4ic0s 86 3 based base VBN cord-007385-xcx4ic0s 86 4 on on IN cord-007385-xcx4ic0s 86 5 a a DT cord-007385-xcx4ic0s 86 6 better well JJR cord-007385-xcx4ic0s 86 7 understanding understanding NN cord-007385-xcx4ic0s 86 8 of of IN cord-007385-xcx4ic0s 86 9 the the DT cord-007385-xcx4ic0s 86 10 pathophysiology pathophysiology NN cord-007385-xcx4ic0s 86 11 of of IN cord-007385-xcx4ic0s 86 12 URIs uri NNS cord-007385-xcx4ic0s 86 13 . . . cord-007385-xcx4ic0s 87 1 Ineffectiveness ineffectiveness NN cord-007385-xcx4ic0s 87 2 of of IN cord-007385-xcx4ic0s 87 3 recombinant recombinant JJ cord-007385-xcx4ic0s 87 4 interferon interferon NN cord-007385-xcx4ic0s 87 5 - - HYPH cord-007385-xcx4ic0s 87 6 beta beta NN cord-007385-xcx4ic0s 87 7 serine serine JJ cord-007385-xcx4ic0s 87 8 nasal nasal NN cord-007385-xcx4ic0s 87 9 drops drop NNS cord-007385-xcx4ic0s 87 10 for for IN cord-007385-xcx4ic0s 87 11 prophylaxis prophylaxis NN cord-007385-xcx4ic0s 87 12 of of IN cord-007385-xcx4ic0s 87 13 natural natural JJ cord-007385-xcx4ic0s 87 14 colds cold NNS cord-007385-xcx4ic0s 87 15 Chemical Chemical NNP cord-007385-xcx4ic0s 87 16 disinfection disinfection NN cord-007385-xcx4ic0s 87 17 interrupt interrupt VBP cord-007385-xcx4ic0s 87 18 transfer transfer NN cord-007385-xcx4ic0s 87 19 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 87 20 type type NN cord-007385-xcx4ic0s 87 21 14 14 CD cord-007385-xcx4ic0s 87 22 from from IN cord-007385-xcx4ic0s 87 23 environmental environmental JJ cord-007385-xcx4ic0s 87 24 surfaces surface NNS cord-007385-xcx4ic0s 87 25 to to IN cord-007385-xcx4ic0s 87 26 hands hand NNS cord-007385-xcx4ic0s 87 27 Potential potential JJ cord-007385-xcx4ic0s 87 28 role role NN cord-007385-xcx4ic0s 87 29 of of IN cord-007385-xcx4ic0s 87 30 hands hand NNS cord-007385-xcx4ic0s 87 31 in in IN cord-007385-xcx4ic0s 87 32 the the DT cord-007385-xcx4ic0s 87 33 spread spread NN cord-007385-xcx4ic0s 87 34 of of IN cord-007385-xcx4ic0s 87 35 respiratory respiratory JJ cord-007385-xcx4ic0s 87 36 viral viral JJ cord-007385-xcx4ic0s 87 37 infections infection NNS cord-007385-xcx4ic0s 87 38 : : : cord-007385-xcx4ic0s 87 39 studies study NNS cord-007385-xcx4ic0s 87 40 with with IN cord-007385-xcx4ic0s 87 41 human human JJ cord-007385-xcx4ic0s 87 42 parainfluenza parainfluenza NNP cord-007385-xcx4ic0s 87 43 virus virus NNP cord-007385-xcx4ic0s 87 44 3 3 CD cord-007385-xcx4ic0s 87 45 and and CC cord-007385-xcx4ic0s 87 46 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 87 47 14 14 CD cord-007385-xcx4ic0s 87 48 Signs sign NNS cord-007385-xcx4ic0s 87 49 and and CC cord-007385-xcx4ic0s 87 50 symptoms symptom NNS cord-007385-xcx4ic0s 87 51 in in IN cord-007385-xcx4ic0s 87 52 common common JJ cord-007385-xcx4ic0s 87 53 colds cold NNS cord-007385-xcx4ic0s 87 54 Development Development NNP cord-007385-xcx4ic0s 87 55 of of IN cord-007385-xcx4ic0s 87 56 common common JJ cord-007385-xcx4ic0s 87 57 cold cold JJ cord-007385-xcx4ic0s 87 58 symptoms symptom NNS cord-007385-xcx4ic0s 87 59 following follow VBG cord-007385-xcx4ic0s 87 60 experimental experimental JJ cord-007385-xcx4ic0s 87 61 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 87 62 infection infection NN cord-007385-xcx4ic0s 87 63 is be VBZ cord-007385-xcx4ic0s 87 64 related relate VBN cord-007385-xcx4ic0s 87 65 to to IN cord-007385-xcx4ic0s 87 66 prior prior JJ cord-007385-xcx4ic0s 87 67 stressful stressful JJ cord-007385-xcx4ic0s 87 68 life life NN cord-007385-xcx4ic0s 87 69 events event NNS cord-007385-xcx4ic0s 87 70 Smoking smoking NN cord-007385-xcx4ic0s 87 71 , , , cord-007385-xcx4ic0s 87 72 alcohol alcohol NN cord-007385-xcx4ic0s 87 73 consumption consumption NN cord-007385-xcx4ic0s 87 74 , , , cord-007385-xcx4ic0s 87 75 and and CC cord-007385-xcx4ic0s 87 76 susceptibility susceptibility NN cord-007385-xcx4ic0s 87 77 to to IN cord-007385-xcx4ic0s 87 78 the the DT cord-007385-xcx4ic0s 87 79 common common JJ cord-007385-xcx4ic0s 87 80 cold cold JJ cord-007385-xcx4ic0s 87 81 Adverse adverse JJ cord-007385-xcx4ic0s 87 82 effects effect NNS cord-007385-xcx4ic0s 87 83 of of IN cord-007385-xcx4ic0s 87 84 aspirin aspirin NN cord-007385-xcx4ic0s 87 85 , , , cord-007385-xcx4ic0s 87 86 acetaminophen acetaminophen NN cord-007385-xcx4ic0s 87 87 , , , cord-007385-xcx4ic0s 87 88 and and CC cord-007385-xcx4ic0s 87 89 ibuprofen ibuprofen NN cord-007385-xcx4ic0s 87 90 on on IN cord-007385-xcx4ic0s 87 91 immune immune JJ cord-007385-xcx4ic0s 87 92 function function NN cord-007385-xcx4ic0s 87 93 , , , cord-007385-xcx4ic0s 87 94 viral viral JJ cord-007385-xcx4ic0s 87 95 shedding shedding NN cord-007385-xcx4ic0s 87 96 , , , cord-007385-xcx4ic0s 87 97 and and CC cord-007385-xcx4ic0s 87 98 clinical clinical JJ cord-007385-xcx4ic0s 87 99 status status NN cord-007385-xcx4ic0s 87 100 in in IN cord-007385-xcx4ic0s 87 101 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 87 102 - - HYPH cord-007385-xcx4ic0s 87 103 infected infect VBN cord-007385-xcx4ic0s 87 104 volunteers volunteer NNS cord-007385-xcx4ic0s 87 105 Studies Studies NNPS cord-007385-xcx4ic0s 87 106 with with IN cord-007385-xcx4ic0s 87 107 rhinoviruses rhinovirus NNS cord-007385-xcx4ic0s 87 108 in in IN cord-007385-xcx4ic0s 87 109 volunteers volunteer NNS cord-007385-xcx4ic0s 87 110 : : : cord-007385-xcx4ic0s 87 111 production production NN cord-007385-xcx4ic0s 87 112 of of IN cord-007385-xcx4ic0s 87 113 illness illness NN cord-007385-xcx4ic0s 87 114 , , , cord-007385-xcx4ic0s 87 115 effect effect NN cord-007385-xcx4ic0s 87 116 of of IN cord-007385-xcx4ic0s 87 117 naturally naturally RB cord-007385-xcx4ic0s 87 118 acquired acquire VBN cord-007385-xcx4ic0s 87 119 antibody antibody NN cord-007385-xcx4ic0s 87 120 , , , cord-007385-xcx4ic0s 87 121 and and CC cord-007385-xcx4ic0s 87 122 demonstration demonstration NN cord-007385-xcx4ic0s 87 123 of of IN cord-007385-xcx4ic0s 87 124 a a DT cord-007385-xcx4ic0s 87 125 protective protective JJ cord-007385-xcx4ic0s 87 126 effect effect NN cord-007385-xcx4ic0s 87 127 not not RB cord-007385-xcx4ic0s 87 128 associated associate VBN cord-007385-xcx4ic0s 87 129 with with IN cord-007385-xcx4ic0s 87 130 serum serum NN cord-007385-xcx4ic0s 87 131 antibody antibody NN cord-007385-xcx4ic0s 87 132 Sites site NNS cord-007385-xcx4ic0s 87 133 of of IN cord-007385-xcx4ic0s 87 134 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 87 135 recovery recovery NN cord-007385-xcx4ic0s 87 136 after after IN cord-007385-xcx4ic0s 87 137 point point NN cord-007385-xcx4ic0s 87 138 inoculation inoculation NN cord-007385-xcx4ic0s 87 139 of of IN cord-007385-xcx4ic0s 87 140 the the DT cord-007385-xcx4ic0s 87 141 upper upper JJ cord-007385-xcx4ic0s 87 142 airway airway NNP cord-007385-xcx4ic0s 87 143 Human human JJ cord-007385-xcx4ic0s 87 144 ciliated ciliated JJ cord-007385-xcx4ic0s 87 145 epithelial epithelial JJ cord-007385-xcx4ic0s 87 146 cells cell NNS cord-007385-xcx4ic0s 87 147 in in IN cord-007385-xcx4ic0s 87 148 nasal nasal NN cord-007385-xcx4ic0s 87 149 secretions secretion NNS cord-007385-xcx4ic0s 87 150 Analysis Analysis NNP cord-007385-xcx4ic0s 87 151 of of IN cord-007385-xcx4ic0s 87 152 nasal nasal JJ cord-007385-xcx4ic0s 87 153 secretions secretion NNS cord-007385-xcx4ic0s 87 154 during during IN cord-007385-xcx4ic0s 87 155 experimental experimental JJ cord-007385-xcx4ic0s 87 156 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 87 157 upper upper JJ cord-007385-xcx4ic0s 87 158 respiratory respiratory JJ cord-007385-xcx4ic0s 87 159 infections infection NNS cord-007385-xcx4ic0s 87 160 Microvascular Microvascular NNP cord-007385-xcx4ic0s 87 161 exudative exudative JJ cord-007385-xcx4ic0s 87 162 hyperresponsiveness hyperresponsiveness NN cord-007385-xcx4ic0s 87 163 in in IN cord-007385-xcx4ic0s 87 164 human human JJ cord-007385-xcx4ic0s 87 165 coronavirus coronavirus NN cord-007385-xcx4ic0s 87 166 - - HYPH cord-007385-xcx4ic0s 87 167 induced induce VBN cord-007385-xcx4ic0s 87 168 common common JJ cord-007385-xcx4ic0s 87 169 cold cold JJ cord-007385-xcx4ic0s 87 170 Fireside Fireside NNP cord-007385-xcx4ic0s 87 171 conference conference NN cord-007385-xcx4ic0s 87 172 11 11 CD cord-007385-xcx4ic0s 87 173 . . . cord-007385-xcx4ic0s 88 1 Common common JJ cord-007385-xcx4ic0s 88 2 cold cold JJ cord-007385-xcx4ic0s 88 3 Kinins Kinins NNPS cord-007385-xcx4ic0s 88 4 are be VBP cord-007385-xcx4ic0s 88 5 generated generate VBN cord-007385-xcx4ic0s 88 6 in in IN cord-007385-xcx4ic0s 88 7 nasal nasal JJ cord-007385-xcx4ic0s 88 8 secretions secretion NNS cord-007385-xcx4ic0s 88 9 during during IN cord-007385-xcx4ic0s 88 10 natural natural JJ cord-007385-xcx4ic0s 88 11 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 88 12 colds cold NNS cord-007385-xcx4ic0s 88 13 A a DT cord-007385-xcx4ic0s 88 14 study study NN cord-007385-xcx4ic0s 88 15 of of IN cord-007385-xcx4ic0s 88 16 the the DT cord-007385-xcx4ic0s 88 17 efficacy efficacy NN cord-007385-xcx4ic0s 88 18 of of IN cord-007385-xcx4ic0s 88 19 the the DT cord-007385-xcx4ic0s 88 20 bradykinin bradykinin NN cord-007385-xcx4ic0s 88 21 antogonist antogonist NN cord-007385-xcx4ic0s 88 22 , , , cord-007385-xcx4ic0s 88 23 NPC NPC NNP cord-007385-xcx4ic0s 88 24 567 567 CD cord-007385-xcx4ic0s 88 25 , , , cord-007385-xcx4ic0s 88 26 in in IN cord-007385-xcx4ic0s 88 27 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 88 28 infections infection NNS cord-007385-xcx4ic0s 88 29 in in IN cord-007385-xcx4ic0s 88 30 human human JJ cord-007385-xcx4ic0s 88 31 volunteers volunteer NNS cord-007385-xcx4ic0s 89 1 Peripheral peripheral JJ cord-007385-xcx4ic0s 89 2 blood blood NN cord-007385-xcx4ic0s 89 3 mononuclear mononuclear JJ cord-007385-xcx4ic0s 89 4 cell cell NN cord-007385-xcx4ic0s 89 5 interleukin-2 interleukin-2 IN cord-007385-xcx4ic0s 89 6 and and CC cord-007385-xcx4ic0s 89 7 interferon interferon NN cord-007385-xcx4ic0s 89 8 - - HYPH cord-007385-xcx4ic0s 89 9 gamma gamma NN cord-007385-xcx4ic0s 89 10 production production NN cord-007385-xcx4ic0s 89 11 , , , cord-007385-xcx4ic0s 89 12 cytotoxicity cytotoxicity NN cord-007385-xcx4ic0s 89 13 , , , cord-007385-xcx4ic0s 89 14 and and CC cord-007385-xcx4ic0s 89 15 antigenstimulated antigenstimulated NNP cord-007385-xcx4ic0s 89 16 blastogenesis blastogenesis NNP cord-007385-xcx4ic0s 89 17 during during IN cord-007385-xcx4ic0s 89 18 experimental experimental JJ cord-007385-xcx4ic0s 89 19 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 89 20 infection infection NN cord-007385-xcx4ic0s 89 21 Effect effect NN cord-007385-xcx4ic0s 89 22 of of IN cord-007385-xcx4ic0s 89 23 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 89 24 39 39 CD cord-007385-xcx4ic0s 89 25 infection infection NN cord-007385-xcx4ic0s 89 26 on on IN cord-007385-xcx4ic0s 89 27 cellular cellular JJ cord-007385-xcx4ic0s 89 28 immune immune JJ cord-007385-xcx4ic0s 89 29 parameters parameter NNS cord-007385-xcx4ic0s 89 30 in in IN cord-007385-xcx4ic0s 89 31 allergic allergic JJ cord-007385-xcx4ic0s 89 32 and and CC cord-007385-xcx4ic0s 89 33 nonallergic nonallergic JJ cord-007385-xcx4ic0s 89 34 subjects subject NNS cord-007385-xcx4ic0s 89 35 Increased increase VBN cord-007385-xcx4ic0s 89 36 levels level NNS cord-007385-xcx4ic0s 89 37 of of IN cord-007385-xcx4ic0s 89 38 interleukin-1 interleukin-1 NN cord-007385-xcx4ic0s 89 39 are be VBP cord-007385-xcx4ic0s 89 40 detected detect VBN cord-007385-xcx4ic0s 89 41 in in IN cord-007385-xcx4ic0s 89 42 nasal nasal JJ cord-007385-xcx4ic0s 89 43 secretions secretion NNS cord-007385-xcx4ic0s 89 44 of of IN cord-007385-xcx4ic0s 89 45 volunteers volunteer NNS cord-007385-xcx4ic0s 89 46 during during IN cord-007385-xcx4ic0s 89 47 experimental experimental JJ cord-007385-xcx4ic0s 89 48 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 89 49 colds cold NNS cord-007385-xcx4ic0s 89 50 Chemotherapy chemotherapy NN cord-007385-xcx4ic0s 89 51 of of IN cord-007385-xcx4ic0s 89 52 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 89 53 colds cold NNS cord-007385-xcx4ic0s 89 54 Respiratory respiratory JJ cord-007385-xcx4ic0s 89 55 viruses virus NNS cord-007385-xcx4ic0s 89 56 and and CC cord-007385-xcx4ic0s 89 57 exacerbations exacerbation NNS cord-007385-xcx4ic0s 89 58 of of IN cord-007385-xcx4ic0s 89 59 asthma asthma NN cord-007385-xcx4ic0s 89 60 in in IN cord-007385-xcx4ic0s 89 61 adults adult NNS cord-007385-xcx4ic0s 89 62 Computed compute VBN cord-007385-xcx4ic0s 89 63 tomographic tomographic JJ cord-007385-xcx4ic0s 89 64 study study NN cord-007385-xcx4ic0s 89 65 of of IN cord-007385-xcx4ic0s 89 66 the the DT cord-007385-xcx4ic0s 89 67 common common JJ cord-007385-xcx4ic0s 89 68 cold cold JJ cord-007385-xcx4ic0s 89 69 Physiologic physiologic JJ cord-007385-xcx4ic0s 89 70 abnormalities abnormality NNS cord-007385-xcx4ic0s 89 71 in in IN cord-007385-xcx4ic0s 89 72 the the DT cord-007385-xcx4ic0s 89 73 paranasal paranasal NN cord-007385-xcx4ic0s 89 74 sinuses sinus NNS cord-007385-xcx4ic0s 89 75 during during IN cord-007385-xcx4ic0s 89 76 experimental experimental JJ cord-007385-xcx4ic0s 89 77 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 89 78 colds cold NNS cord-007385-xcx4ic0s 89 79 Middle middle JJ cord-007385-xcx4ic0s 89 80 ear ear NN cord-007385-xcx4ic0s 89 81 abnormalities abnormality NNS cord-007385-xcx4ic0s 89 82 during during IN cord-007385-xcx4ic0s 89 83 natural natural JJ cord-007385-xcx4ic0s 89 84 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 89 85 colds cold NNS cord-007385-xcx4ic0s 89 86 in in IN cord-007385-xcx4ic0s 89 87 adults adult NNS cord-007385-xcx4ic0s 89 88 Effect Effect NNP cord-007385-xcx4ic0s 89 89 of of IN cord-007385-xcx4ic0s 89 90 experimental experimental JJ cord-007385-xcx4ic0s 89 91 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 89 92 39 39 CD cord-007385-xcx4ic0s 89 93 infection infection NN cord-007385-xcx4ic0s 89 94 on on IN cord-007385-xcx4ic0s 89 95 the the DT cord-007385-xcx4ic0s 89 96 nasal nasal NN cord-007385-xcx4ic0s 89 97 response response NN cord-007385-xcx4ic0s 89 98 to to IN cord-007385-xcx4ic0s 89 99 histamine histamine NN cord-007385-xcx4ic0s 89 100 and and CC cord-007385-xcx4ic0s 89 101 cold cold JJ cord-007385-xcx4ic0s 89 102 air air NN cord-007385-xcx4ic0s 89 103 challenges challenge NNS cord-007385-xcx4ic0s 89 104 in in IN cord-007385-xcx4ic0s 89 105 allergic allergic JJ cord-007385-xcx4ic0s 89 106 and and CC cord-007385-xcx4ic0s 89 107 nonallergic nonallergic JJ cord-007385-xcx4ic0s 89 108 subjects subject NNS cord-007385-xcx4ic0s 89 109 Amplified amplify VBD cord-007385-xcx4ic0s 89 110 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 89 111 colds cold NNS cord-007385-xcx4ic0s 89 112 in in IN cord-007385-xcx4ic0s 89 113 atopic atopic JJ cord-007385-xcx4ic0s 89 114 subjects subject NNS cord-007385-xcx4ic0s 89 115 Factors factor NNS cord-007385-xcx4ic0s 89 116 affecting affect VBG cord-007385-xcx4ic0s 89 117 the the DT cord-007385-xcx4ic0s 89 118 long long JJ cord-007385-xcx4ic0s 89 119 - - HYPH cord-007385-xcx4ic0s 89 120 term term NN cord-007385-xcx4ic0s 89 121 variability variability NN cord-007385-xcx4ic0s 89 122 of of IN cord-007385-xcx4ic0s 89 123 bronchial bronchial JJ cord-007385-xcx4ic0s 89 124 responsiveness responsiveness NN cord-007385-xcx4ic0s 89 125 in in IN cord-007385-xcx4ic0s 89 126 an an DT cord-007385-xcx4ic0s 89 127 adult adult NN cord-007385-xcx4ic0s 89 128 general general JJ cord-007385-xcx4ic0s 89 129 practice practice NN cord-007385-xcx4ic0s 89 130 population population NN cord-007385-xcx4ic0s 89 131 Adverse adverse JJ cord-007385-xcx4ic0s 89 132 effects effect NNS cord-007385-xcx4ic0s 89 133 of of IN cord-007385-xcx4ic0s 89 134 aspirin aspirin NN cord-007385-xcx4ic0s 89 135 , , , cord-007385-xcx4ic0s 89 136 acetaminophen acetaminophen NN cord-007385-xcx4ic0s 89 137 , , , cord-007385-xcx4ic0s 89 138 and and CC cord-007385-xcx4ic0s 89 139 ibuprofen ibuprofen NN cord-007385-xcx4ic0s 89 140 on on IN cord-007385-xcx4ic0s 89 141 immune immune JJ cord-007385-xcx4ic0s 89 142 function function NN cord-007385-xcx4ic0s 89 143 , , , cord-007385-xcx4ic0s 89 144 viral viral JJ cord-007385-xcx4ic0s 89 145 shedding shedding NN cord-007385-xcx4ic0s 89 146 , , , cord-007385-xcx4ic0s 89 147 and and CC cord-007385-xcx4ic0s 89 148 clinical clinical JJ cord-007385-xcx4ic0s 89 149 status status NN cord-007385-xcx4ic0s 89 150 in in IN cord-007385-xcx4ic0s 89 151 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 89 152 - - HYPH cord-007385-xcx4ic0s 89 153 infected infect VBN cord-007385-xcx4ic0s 89 154 volunteers volunteer NNS cord-007385-xcx4ic0s 89 155 Effects effect NNS cord-007385-xcx4ic0s 89 156 of of IN cord-007385-xcx4ic0s 89 157 naproxen naproxen NN cord-007385-xcx4ic0s 89 158 on on IN cord-007385-xcx4ic0s 89 159 experimental experimental JJ cord-007385-xcx4ic0s 89 160 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 89 161 colds cold NNS cord-007385-xcx4ic0s 89 162 : : : cord-007385-xcx4ic0s 89 163 a a DT cord-007385-xcx4ic0s 89 164 randomized randomized JJ cord-007385-xcx4ic0s 89 165 , , , cord-007385-xcx4ic0s 89 166 double double JJ cord-007385-xcx4ic0s 89 167 - - HYPH cord-007385-xcx4ic0s 89 168 blind blind JJ cord-007385-xcx4ic0s 89 169 , , , cord-007385-xcx4ic0s 89 170 controlled controlled JJ cord-007385-xcx4ic0s 89 171 trial trial NN cord-007385-xcx4ic0s 89 172 Pathophysiology pathophysiology NN cord-007385-xcx4ic0s 89 173 and and CC cord-007385-xcx4ic0s 89 174 pharmacotherapy pharmacotherapy NN cord-007385-xcx4ic0s 89 175 of of IN cord-007385-xcx4ic0s 89 176 common common JJ cord-007385-xcx4ic0s 89 177 upper upper JJ cord-007385-xcx4ic0s 89 178 respiratory respiratory JJ cord-007385-xcx4ic0s 89 179 diseases disease NNS cord-007385-xcx4ic0s 89 180 Evaluation Evaluation NNP cord-007385-xcx4ic0s 89 181 of of IN cord-007385-xcx4ic0s 89 182 an an DT cord-007385-xcx4ic0s 89 183 alpha alpha NN cord-007385-xcx4ic0s 89 184 agonist agonist NN cord-007385-xcx4ic0s 89 185 alone alone RB cord-007385-xcx4ic0s 89 186 and and CC cord-007385-xcx4ic0s 89 187 in in IN cord-007385-xcx4ic0s 89 188 combination combination NN cord-007385-xcx4ic0s 89 189 with with IN cord-007385-xcx4ic0s 89 190 a a DT cord-007385-xcx4ic0s 89 191 nonsteroidal nonsteroidal JJ cord-007385-xcx4ic0s 89 192 antiinflammatory antiinflammatory JJ cord-007385-xcx4ic0s 89 193 agent agent NN cord-007385-xcx4ic0s 89 194 in in IN cord-007385-xcx4ic0s 89 195 the the DT cord-007385-xcx4ic0s 89 196 treatment treatment NN cord-007385-xcx4ic0s 89 197 of of IN cord-007385-xcx4ic0s 89 198 experimental experimental JJ cord-007385-xcx4ic0s 89 199 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 89 200 colds cold NNS cord-007385-xcx4ic0s 89 201 Evaluation Evaluation NNP cord-007385-xcx4ic0s 89 202 of of IN cord-007385-xcx4ic0s 89 203 oral oral JJ cord-007385-xcx4ic0s 89 204 terfenadine terfenadine NN cord-007385-xcx4ic0s 89 205 for for IN cord-007385-xcx4ic0s 89 206 treatment treatment NN cord-007385-xcx4ic0s 89 207 of of IN cord-007385-xcx4ic0s 89 208 the the DT cord-007385-xcx4ic0s 89 209 common common JJ cord-007385-xcx4ic0s 89 210 cold cold JJ cord-007385-xcx4ic0s 89 211 Effectiveness Effectiveness NNP cord-007385-xcx4ic0s 89 212 of of IN cord-007385-xcx4ic0s 89 213 an an DT cord-007385-xcx4ic0s 89 214 antihistamine antihistamine NN cord-007385-xcx4ic0s 89 215 - - HYPH cord-007385-xcx4ic0s 89 216 decongestant decongestant NN cord-007385-xcx4ic0s 89 217 combination combination NN cord-007385-xcx4ic0s 89 218 for for IN cord-007385-xcx4ic0s 89 219 young young JJ cord-007385-xcx4ic0s 89 220 children child NNS cord-007385-xcx4ic0s 89 221 with with IN cord-007385-xcx4ic0s 89 222 the the DT cord-007385-xcx4ic0s 89 223 common common JJ cord-007385-xcx4ic0s 89 224 cold cold NN cord-007385-xcx4ic0s 89 225 : : : cord-007385-xcx4ic0s 89 226 a a DT cord-007385-xcx4ic0s 89 227 randomized randomized JJ cord-007385-xcx4ic0s 89 228 , , , cord-007385-xcx4ic0s 89 229 controlled control VBN cord-007385-xcx4ic0s 89 230 clinical clinical JJ cord-007385-xcx4ic0s 89 231 trial trial NN cord-007385-xcx4ic0s 89 232 Over over IN cord-007385-xcx4ic0s 89 233 - - HYPH cord-007385-xcx4ic0s 89 234 the the DT cord-007385-xcx4ic0s 89 235 - - HYPH cord-007385-xcx4ic0s 89 236 counter counter NN cord-007385-xcx4ic0s 89 237 cold cold JJ cord-007385-xcx4ic0s 89 238 medications medication NNS cord-007385-xcx4ic0s 89 239 : : : cord-007385-xcx4ic0s 89 240 a a DT cord-007385-xcx4ic0s 89 241 critical critical JJ cord-007385-xcx4ic0s 89 242 review review NN cord-007385-xcx4ic0s 89 243 of of IN cord-007385-xcx4ic0s 89 244 clinical clinical JJ cord-007385-xcx4ic0s 89 245 trials trial NNS cord-007385-xcx4ic0s 89 246 between between IN cord-007385-xcx4ic0s 89 247 1950 1950 CD cord-007385-xcx4ic0s 89 248 and and CC cord-007385-xcx4ic0s 89 249 1991 1991 CD cord-007385-xcx4ic0s 90 1 The the DT cord-007385-xcx4ic0s 90 2 effect effect NN cord-007385-xcx4ic0s 90 3 of of IN cord-007385-xcx4ic0s 90 4 intranasal intranasal NN cord-007385-xcx4ic0s 90 5 nedocromil nedocromil NN cord-007385-xcx4ic0s 90 6 sodium sodium NN cord-007385-xcx4ic0s 90 7 on on IN cord-007385-xcx4ic0s 90 8 viral viral JJ cord-007385-xcx4ic0s 90 9 upper upper JJ cord-007385-xcx4ic0s 90 10 respiratory respiratory JJ cord-007385-xcx4ic0s 90 11 tract tract NN cord-007385-xcx4ic0s 90 12 infections infection NNS cord-007385-xcx4ic0s 90 13 in in IN cord-007385-xcx4ic0s 90 14 human human JJ cord-007385-xcx4ic0s 90 15 volunteers volunteer NNS cord-007385-xcx4ic0s 91 1 Intranasal intranasal NN cord-007385-xcx4ic0s 91 2 sodium sodium NN cord-007385-xcx4ic0s 91 3 cromoglycate cromoglycate NNP cord-007385-xcx4ic0s 91 4 in in IN cord-007385-xcx4ic0s 91 5 post post JJ cord-007385-xcx4ic0s 91 6 - - JJ cord-007385-xcx4ic0s 91 7 catarrhal catarrhal JJ cord-007385-xcx4ic0s 91 8 hyperreactive hyperreactive JJ cord-007385-xcx4ic0s 91 9 rhinosinusitis rhinosinusitis NN cord-007385-xcx4ic0s 91 10 : : : cord-007385-xcx4ic0s 91 11 a a DT cord-007385-xcx4ic0s 91 12 double double JJ cord-007385-xcx4ic0s 91 13 - - HYPH cord-007385-xcx4ic0s 91 14 blind blind JJ cord-007385-xcx4ic0s 91 15 placebo placebo NN cord-007385-xcx4ic0s 91 16 controlled control VBN cord-007385-xcx4ic0s 91 17 trial trial NN cord-007385-xcx4ic0s 91 18 The the DT cord-007385-xcx4ic0s 91 19 effects effect NNS cord-007385-xcx4ic0s 91 20 of of IN cord-007385-xcx4ic0s 91 21 menthol menthol NN cord-007385-xcx4ic0s 91 22 on on IN cord-007385-xcx4ic0s 91 23 reaction reaction NN cord-007385-xcx4ic0s 91 24 time time NN cord-007385-xcx4ic0s 91 25 and and CC cord-007385-xcx4ic0s 91 26 nasal nasal NN cord-007385-xcx4ic0s 91 27 sensation sensation NN cord-007385-xcx4ic0s 91 28 of of IN cord-007385-xcx4ic0s 91 29 airflow airflow NN cord-007385-xcx4ic0s 91 30 in in IN cord-007385-xcx4ic0s 91 31 subjects subject NNS cord-007385-xcx4ic0s 91 32 suffering suffer VBG cord-007385-xcx4ic0s 91 33 from from IN cord-007385-xcx4ic0s 91 34 the the DT cord-007385-xcx4ic0s 91 35 common common JJ cord-007385-xcx4ic0s 91 36 cold cold JJ cord-007385-xcx4ic0s 91 37 Ineffectiveness Ineffectiveness NNP cord-007385-xcx4ic0s 91 38 of of IN cord-007385-xcx4ic0s 91 39 recombinant recombinant JJ cord-007385-xcx4ic0s 91 40 interferon interferon NN cord-007385-xcx4ic0s 91 41 - - HYPH cord-007385-xcx4ic0s 91 42 beta beta NN cord-007385-xcx4ic0s 91 43 serine serine JJ cord-007385-xcx4ic0s 91 44 nasal nasal NN cord-007385-xcx4ic0s 91 45 drops drop NNS cord-007385-xcx4ic0s 91 46 for for IN cord-007385-xcx4ic0s 91 47 prophylaxis prophylaxis NN cord-007385-xcx4ic0s 91 48 of of IN cord-007385-xcx4ic0s 91 49 natural natural JJ cord-007385-xcx4ic0s 91 50 colds cold NNS cord-007385-xcx4ic0s 91 51 Ineffectiveness Ineffectiveness NNP cord-007385-xcx4ic0s 91 52 of of IN cord-007385-xcx4ic0s 91 53 postexposurc postexposurc NNS cord-007385-xcx4ic0s 91 54 prophylaxis prophylaxis NN cord-007385-xcx4ic0s 91 55 of of IN cord-007385-xcx4ic0s 91 56 rhinovirus rhinovirus JJ cord-007385-xcx4ic0s 91 57 infection infection NN cord-007385-xcx4ic0s 91 58 with with IN cord-007385-xcx4ic0s 91 59 lowdose lowdose NNP cord-007385-xcx4ic0s 91 60 intranasal intranasal NNP cord-007385-xcx4ic0s 91 61 alpha alpha NNP cord-007385-xcx4ic0s 91 62 2b 2b NNP cord-007385-xcx4ic0s 91 63 interferon interferon NNP cord-007385-xcx4ic0s 91 64 in in IN cord-007385-xcx4ic0s 91 65 families family NNS cord-007385-xcx4ic0s 91 66 Recombinant recombinant JJ cord-007385-xcx4ic0s 91 67 human human JJ cord-007385-xcx4ic0s 91 68 interferon interferon NN cord-007385-xcx4ic0s 91 69 - - HYPH cord-007385-xcx4ic0s 91 70 gamma gamma NN cord-007385-xcx4ic0s 91 71 as as IN cord-007385-xcx4ic0s 91 72 prophylaxis prophylaxis NN cord-007385-xcx4ic0s 91 73 against against IN cord-007385-xcx4ic0s 91 74 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 91 75 colds cold NNS cord-007385-xcx4ic0s 91 76 in in IN cord-007385-xcx4ic0s 91 77 volunteers volunteer NNS cord-007385-xcx4ic0s 92 1 A a DT cord-007385-xcx4ic0s 92 2 randomized randomized JJ cord-007385-xcx4ic0s 92 3 controlled control VBN cord-007385-xcx4ic0s 92 4 trial trial NN cord-007385-xcx4ic0s 92 5 of of IN cord-007385-xcx4ic0s 92 6 glucocorticoid glucocorticoid NN cord-007385-xcx4ic0s 92 7 prophylaxis prophylaxis NN cord-007385-xcx4ic0s 92 8 against against IN cord-007385-xcx4ic0s 92 9 experimental experimental JJ cord-007385-xcx4ic0s 92 10 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 92 11 infection infection NN cord-007385-xcx4ic0s 92 12 Effect effect NN cord-007385-xcx4ic0s 92 13 of of IN cord-007385-xcx4ic0s 92 14 inhaling inhale VBG cord-007385-xcx4ic0s 92 15 heated heated JJ cord-007385-xcx4ic0s 92 16 vapor vapor NN cord-007385-xcx4ic0s 92 17 on on IN cord-007385-xcx4ic0s 92 18 symptoms symptom NNS cord-007385-xcx4ic0s 92 19 of of IN cord-007385-xcx4ic0s 92 20 the the DT cord-007385-xcx4ic0s 92 21 common common JJ cord-007385-xcx4ic0s 92 22 cold cold JJ cord-007385-xcx4ic0s 92 23 Effect effect NN cord-007385-xcx4ic0s 92 24 of of IN cord-007385-xcx4ic0s 92 25 inhaling inhale VBG cord-007385-xcx4ic0s 92 26 heated heated JJ cord-007385-xcx4ic0s 92 27 vapor vapor NN cord-007385-xcx4ic0s 92 28 on on IN cord-007385-xcx4ic0s 92 29 symptoms symptom NNS cord-007385-xcx4ic0s 92 30 of of IN cord-007385-xcx4ic0s 92 31 the the DT cord-007385-xcx4ic0s 92 32 common common JJ cord-007385-xcx4ic0s 92 33 cold cold JJ cord-007385-xcx4ic0s 92 34 Local local JJ cord-007385-xcx4ic0s 92 35 hyperthermia hyperthermia NN cord-007385-xcx4ic0s 92 36 benefits benefit VBZ cord-007385-xcx4ic0s 92 37 natural natural JJ cord-007385-xcx4ic0s 92 38 and and CC cord-007385-xcx4ic0s 92 39 experimental experimental JJ cord-007385-xcx4ic0s 92 40 common common JJ cord-007385-xcx4ic0s 92 41 colds cold NNS cord-007385-xcx4ic0s 93 1 Regular regular JJ cord-007385-xcx4ic0s 93 2 sauna sauna NN cord-007385-xcx4ic0s 93 3 bathing bathing NN cord-007385-xcx4ic0s 93 4 and and CC cord-007385-xcx4ic0s 93 5 the the DT cord-007385-xcx4ic0s 93 6 incidence incidence NN cord-007385-xcx4ic0s 93 7 of of IN cord-007385-xcx4ic0s 93 8 common common JJ cord-007385-xcx4ic0s 93 9 colds cold NNS cord-007385-xcx4ic0s 93 10 Zinc zinc NN cord-007385-xcx4ic0s 93 11 gluconate gluconate VBP cord-007385-xcx4ic0s 93 12 lozenges lozenge NNS cord-007385-xcx4ic0s 93 13 for for IN cord-007385-xcx4ic0s 93 14 common common JJ cord-007385-xcx4ic0s 93 15 cold cold NN cord-007385-xcx4ic0s 93 16 : : : cord-007385-xcx4ic0s 93 17 a a DT cord-007385-xcx4ic0s 93 18 double double JJ cord-007385-xcx4ic0s 93 19 - - HYPH cord-007385-xcx4ic0s 93 20 blind blind JJ cord-007385-xcx4ic0s 93 21 clinical clinical JJ cord-007385-xcx4ic0s 93 22 trial trial NN cord-007385-xcx4ic0s 93 23 Zinc Zinc NNP cord-007385-xcx4ic0s 93 24 gluconate gluconate NN cord-007385-xcx4ic0s 93 25 and and CC cord-007385-xcx4ic0s 93 26 the the DT cord-007385-xcx4ic0s 93 27 common common JJ cord-007385-xcx4ic0s 93 28 cold cold NN cord-007385-xcx4ic0s 93 29 : : : cord-007385-xcx4ic0s 94 1 a a DT cord-007385-xcx4ic0s 94 2 controlled control VBN cord-007385-xcx4ic0s 94 3 clinical clinical JJ cord-007385-xcx4ic0s 94 4 study study NN cord-007385-xcx4ic0s 94 5 Vitamin vitamin NN cord-007385-xcx4ic0s 94 6 C C NNP cord-007385-xcx4ic0s 94 7 and and CC cord-007385-xcx4ic0s 94 8 the the DT cord-007385-xcx4ic0s 94 9 common common JJ cord-007385-xcx4ic0s 94 10 cold cold NN cord-007385-xcx4ic0s 95 1 Does do VBZ cord-007385-xcx4ic0s 95 2 vitamin vitamin NN cord-007385-xcx4ic0s 95 3 C C NNP cord-007385-xcx4ic0s 95 4 alleviate alleviate VB cord-007385-xcx4ic0s 95 5 the the DT cord-007385-xcx4ic0s 95 6 symptoms symptom NNS cord-007385-xcx4ic0s 95 7 of of IN cord-007385-xcx4ic0s 95 8 the the DT cord-007385-xcx4ic0s 95 9 common common JJ cord-007385-xcx4ic0s 95 10 cold cold NN cord-007385-xcx4ic0s 95 11 ? ? . cord-007385-xcx4ic0s 95 12 : : : cord-007385-xcx4ic0s 96 1 a a DT cord-007385-xcx4ic0s 96 2 review review NN cord-007385-xcx4ic0s 96 3 of of IN cord-007385-xcx4ic0s 96 4 current current JJ cord-007385-xcx4ic0s 96 5 evidence evidence NN cord-007385-xcx4ic0s 96 6 Effects effect NNS cord-007385-xcx4ic0s 96 7 of of IN cord-007385-xcx4ic0s 96 8 drinking drink VBG cord-007385-xcx4ic0s 96 9 hot hot JJ cord-007385-xcx4ic0s 96 10 water water NN cord-007385-xcx4ic0s 96 11 , , , cord-007385-xcx4ic0s 96 12 cold cold JJ cord-007385-xcx4ic0s 96 13 water water NN cord-007385-xcx4ic0s 96 14 , , , cord-007385-xcx4ic0s 96 15 and and CC cord-007385-xcx4ic0s 96 16 chicken chicken NN cord-007385-xcx4ic0s 96 17 soup soup NN cord-007385-xcx4ic0s 96 18 on on IN cord-007385-xcx4ic0s 96 19 nasal nasal NN cord-007385-xcx4ic0s 96 20 ¢,~ ¢,~ CD cord-007385-xcx4ic0s 97 1 ~pec'~or ~pec'~or NNP cord-007385-xcx4ic0s 98 1 ~ucus ~ucus JJ cord-007385-xcx4ic0s 98 2 velocity velocity NN cord-007385-xcx4ic0s 98 3 and and CC cord-007385-xcx4ic0s 98 4 nasal nasal NN cord-007385-xcx4ic0s 98 5 airflow airflow NN cord-007385-xcx4ic0s 98 6 resistance resistance NN cord-007385-xcx4ic0s 98 7 Therapeutic therapeutic JJ cord-007385-xcx4ic0s 98 8 effects effect NNS cord-007385-xcx4ic0s 98 9 of of IN cord-007385-xcx4ic0s 98 10 an an DT cord-007385-xcx4ic0s 98 11 anticboinergic anticboinergic JJ cord-007385-xcx4ic0s 98 12 - - HYPH cord-007385-xcx4ic0s 98 13 sympathomimetic sympathomimetic JJ cord-007385-xcx4ic0s 98 14 combination combination NN cord-007385-xcx4ic0s 98 15 in in IN cord-007385-xcx4ic0s 98 16 induced induce VBN cord-007385-xcx4ic0s 98 17 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 98 18 colds cold NNS cord-007385-xcx4ic0s 98 19 A a DT cord-007385-xcx4ic0s 98 20 double double JJ cord-007385-xcx4ic0s 98 21 - - HYPH cord-007385-xcx4ic0s 98 22 blind blind JJ cord-007385-xcx4ic0s 98 23 , , , cord-007385-xcx4ic0s 98 24 placebo placebo NN cord-007385-xcx4ic0s 98 25 - - HYPH cord-007385-xcx4ic0s 98 26 controlled control VBN cord-007385-xcx4ic0s 98 27 study study NN cord-007385-xcx4ic0s 98 28 of of IN cord-007385-xcx4ic0s 98 29 the the DT cord-007385-xcx4ic0s 98 30 safety safety NN cord-007385-xcx4ic0s 98 31 and and CC cord-007385-xcx4ic0s 98 32 efficacy efficacy NN cord-007385-xcx4ic0s 98 33 of of IN cord-007385-xcx4ic0s 98 34 ipratropium ipratropium NN cord-007385-xcx4ic0s 98 35 bromide bromide NN cord-007385-xcx4ic0s 98 36 nasal nasal NN cord-007385-xcx4ic0s 98 37 spray spray NN cord-007385-xcx4ic0s 98 38 versus versus IN cord-007385-xcx4ic0s 98 39 placebo placebo NN cord-007385-xcx4ic0s 98 40 in in IN cord-007385-xcx4ic0s 98 41 patients patient NNS cord-007385-xcx4ic0s 98 42 with with IN cord-007385-xcx4ic0s 98 43 the the DT cord-007385-xcx4ic0s 98 44 common common JJ cord-007385-xcx4ic0s 98 45 cold cold JJ cord-007385-xcx4ic0s 98 46 Modification modification NN cord-007385-xcx4ic0s 98 47 of of IN cord-007385-xcx4ic0s 98 48 experimental experimental JJ cord-007385-xcx4ic0s 98 49 rhinovirus rhinovirus NN cord-007385-xcx4ic0s 98 50 colds cold NNS cord-007385-xcx4ic0s 98 51 by by IN cord-007385-xcx4ic0s 98 52 receptor receptor NN cord-007385-xcx4ic0s 98 53 blockade blockade NN