id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-266589-oj76ol8v	Wan, Marilyn T.	The risk of respiratory tract infections and symptoms in psoriasis patients treated with IL-17-pathway inhibiting biologics: A meta-estimate of pivotal trials relevant to decision-making during the COVID-19 pandemic	2020-05-19		.txt	text/plain	818	54	50	title: The risk of respiratory tract infections and symptoms in psoriasis patients treated with IL-17-pathway inhibiting biologics: A meta-estimate of pivotal trials relevant to decision-making during the COVID-19 pandemic 4 12 To test this hypothesis, we calculated a meta-estimate from the placebo-controlled period 13 of phase 3 pivotal IL-17 trials of terms consistent with RTI of secukinumab, ixekizumab, and 14 We found an increased risk of RTIs in the IL-17 groups as 19 compared to placebo (odds ratio 1.56, 95% Confidence Interval 1.04-2.33; Table 1 ). Since 20 prescribing information is not inclusive of all respiratory AEs from the pivotal trials that 21 supported approval of interleukin-17 inhibitors, we conducted a summary risk estimate using 22 data from the placebo-controlled period of these studies obtained from clinicaltrials.gov. This 23 more detailed analysis yielded similar findings to our meta-estimate of prescribing information 24 data (odds ratio 1.31, 95% Confidence Interval 1.05-1.62; Table 2 ).	./cache/cord-266589-oj76ol8v.txt	./txt/cord-266589-oj76ol8v.txt