id author title date pages extension mime words sentences flesch summary cache txt cord-303800-h3lvbldz Schultz, Brittney Reply to “Treatment considerations for patients with pemphigus during the COVID-19 pandemic” 2020-09-04 .txt text/plain 483 38 51 title: Reply to "Treatment considerations for patients with pemphigus during the COVID-19 pandemic" In particular, rituximab should be considered 43 for patients with severe disease and without active COVID-19 illness after discussion of specific 44 individual-level risks (age, comorbidities, occupation) and benefits of rituximab. We would also 45 consider rituximab for younger patients without comorbidities and with less severe disease. We have limited data directly 47 comparing adverse events in those treated with rituximab versus other therapies but compared to 48 prednisone alone, individuals treated with rituximab plus short-term prednisone had decreased 49 cumulative exposure to prednisone and fewer adverse effects, 2 including known risk factors for Conversely, physicians should discuss that rituximab may reduce immune response to 63 vaccination, 5 which may decrease the ability of patients to effectively receive a COVID-19 64 vaccine. Treatment considerations for patients 80 with pemphigus during the COVID-19 pandemic ./cache/cord-303800-h3lvbldz.txt ./txt/cord-303800-h3lvbldz.txt