id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-329353-0pwgzeec	Wambier, Carlos Gustavo	Male balding as a major risk factor for severe COVID-19: a possible role for targeting androgens and transmembrane protease serine 2 to protect vulnerable individuals	2020-09-11		.txt	text/plain	704	58	56	title: Male balding as a major risk factor for severe COVID-19: a possible role for targeting androgens and transmembrane protease serine 2 to protect vulnerable individuals Keywords: COVID-19; SARS-CoV-2; Gabrin sign; vulnerability; androgen receptor; androgenetic 29 alopecia; anti-androgen therapy; transmembrane protease serine 2; TMPRSS2; Dutasteride; 7. 4 Recently, results of a study using 58 J o u r n a l P r e -p r o o f bromhexine hydrochloride, a common cough over-the-counter medication only available 59 outside the United States were reported. 4 Results of our recent COVID-19 prospective cohort study 67 involving 77 hospitalized men were also particularly encouraging: Only 1 out of 12 individuals 68 were admitted to the ICU (8%) in the cohort of men using 5-alpha-reductase inhibitors or other 69 anti-androgen drugs (dutasteride=9, finasteride=2, and spironolactone=1), versus 38 out of 65 70 men (58%) not taking anti-androgens (p=0.0015). Medications that target TMPRSS2 have demonstrated improved COVID-19 outcomes in clinical 73 studies, and have the potential to protect vulnerable individuals during the pandemic.	./cache/cord-329353-0pwgzeec.txt	./txt/cord-329353-0pwgzeec.txt