id author title date pages extension mime words sentences flesch summary cache txt cord-350317-a9qd3xdr Xu, Qiannan If skin is a potential host of SARS-CoV-2, IL-17 antibody could reduce the risk of COVID-19 2020-11-05 .txt text/plain 700 49 58 title: If skin is a potential host of SARS-CoV-2, IL-17 antibody could reduce the risk of COVID-19 The expression of ACE2 is associated with the potential risk of making the target tissue susceptible to infection by SARS-CoV-2. Elevated ACE2 expression and detection of SARS-CoV-2 in the skin 4 of COVID-19 patients implied skin was a potential host of SARS-CoV-2. After IL-17 antibody treatment, the skin ACE2 expression was downregulated which meant IL-17 antibody could lower the risk of COVID-19 through lessening the cells which could interact with SARS-CoV-2. Additionally, IL-17 antibody could reverse the deteriorated barrier and inflammatory status in the skin of psoriasis patient which meant less microbe infection.Herein, the specific microbe could be SARS-CoV-2. Thus, whether IL-17 antibody could reduce the COVID-19 risk through reversing the inflammatory skin status with deteriorated barrier and preventing SARS-CoV-2 transmitting should be further discussed. Skin is a potential host of SARS-CoV-2: a clinical, single-cell transcriptome-profiling and histological study ./cache/cord-350317-a9qd3xdr.txt ./txt/cord-350317-a9qd3xdr.txt