key: cord-262311-vdbk50pl
authors: Grant-Kels, Jane M.
title: Response to “Risks of Hydroxychloroquine use for COVID-19 prophylaxis”
date: 2020-04-26
journal: J Am Acad Dermatol
DOI: 10.1016/j.jaad.2020.04.112
sha: 
doc_id: 262311
cord_uid: vdbk50pl

nan

prophylaxis" HCQ has been demonstrated to be anti-viral but is also known for its successful antiinflammatory actions that has resulted in it being used extensively in autoimmune diseases; it can significantly decrease the production of cytokines and, in particular, proinflammatory factors. 7. Although the rheumatologic literature has demonstrated that HCQ is less toxic than chloroquine and a very safe medication, prolonged use and overdosing can still cause problems for our patients; major concerns surround the potential for ventricular arrhythmias, QT prolongation, and other cardiac toxicities.

I applaud those at the front line trying desperately to help those suffering with this virus.

A recent Wall Street Journal article reported data compiled from the Global Rheumatology Alliance (a coalition of rheumatologists) that more than five dozen "people taking hydroxychloroquine and other treatments for chronic rheumatologic diseases have become infected with Covid-19, according to an analysis of emerging data that is a sign the drugs may not protect people from the new coronavirus." 8. These findings cast doubt on the effectiveness of HCZ prophylaxis.

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