key: cord-285691-pceenwb6
authors: Falo, Louis D.
title: Advances in skin science enable the development of a COVID-19 Vaccine
date: 2020-05-30
journal: J Am Acad Dermatol
DOI: 10.1016/j.jaad.2020.05.126
sha: 
doc_id: 285691
cord_uid: pceenwb6

nan

expressing adenovectors and adjuvant in the same MNAs resulting in a vaccine that induced both antibody responses and enhanced cytotoxic cellular immunity that is likely important for "universal" vaccines and cancer immunotherapies.

Taken together, these and studies by others demonstrate the potential for the development of cutaneous immune engineering strategies to control systemic immune responses including the potential for developing novel vaccine strategies and immunotherapies, and even negative immunization strategies to treat systemic allergy and autoimmune diseases. Advances in skin biology are making important contributions to the fight against the COVID-19 pandemic demonstrating once again that dermatology is more than skin deep.

The immunological anatomy of the skin

Antigen-Presenting cells in the skin

Microneedles for drug and vaccine delivery

Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development

Improved cutaneous genetic immunization by microneedle array delivery of an adjuvanted adenovirus vaccine