id author title date pages extension mime words sentences flesch summary cache txt cord-026603-h4zy3244 Gallo, Oreste “Is really the cancer population at risk for more severe COVID-19? Some hints from the cytokine profile” 2020-06-10 .txt text/plain 960 58 48 [1] The official death toll of the COVID-19 pandemic has reached, as of May 27th, 350 000 and it is now recognised that severe outcomes of this infection are associated to a complex dysregulated immune response to SARS-CoV-2 which clinically translates into acute respiratory distress syndrome, the cytokine release syndrome, the secondary hemophagocytic lymphohistiocytosis, and the disseminated intravascular coagulation. [5] On the contrary, other authors have subsequently suggested that cancer patients, because of their impaired immune system due to the tumour itself and its therapies, are expected to have a reduced systemic inflammatory response to the virus and, thus, non-inferior mortality rates. [8] Overall, our findings seem to confirm the role of age as one of the strongest prognostic factors; in addition, we suggest that cancer patients are not necessarily at higher risk for COVID-19 associated death because their impaired immune responsiveness might act as a protective factor from the cytokine storm. ./cache/cord-026603-h4zy3244.txt ./txt/cord-026603-h4zy3244.txt