id author title date pages extension mime words sentences flesch summary cache txt cord-260925-puuqv6zk Wen, Feng Identification of the hyper-variable genomic hotspot for the novel coronavirus SARS-CoV-2 2020-03-05 .txt text/plain 1171 70 56 title: Identification of the hyper-variable genomic hotspot for the novel coronavirus SARS-CoV-2 The sequences NC_004718.3 of SARS coronavirus 6 genes were utilized to define the protein products of SARS-CoV-2. First, the protein sequences of SARS-CoV-2 were compared with RaTG13, human SARS (NC_004718.3), bat SARS (DQ022305.2), and human MERS (NC_019843.3) by calculating the similarity in a given sliding window ( Fig. 1 A) . These results suggested that there had probably been no hyper-variable genomic hotspot in the SARS-CoV-2 population until now. The hyper-variable genomic hotspot has been established in the SARS-CoV-2 population at the nucleotide but not the amino acid level, suggesting that there have been no beneficial mutations. mutations in nsp1, nsp3, nsp15, and gene S that identified in this study would be associated with the SARS-CoV-2 epidemic and was worthy of further study. The genome sequence of the SARS-associated coronavirus ./cache/cord-260925-puuqv6zk.txt ./txt/cord-260925-puuqv6zk.txt