id author title date pages extension mime words sentences flesch summary cache txt cord-265772-diahoew3 Zhang, Yue Genotype shift in human coronavirus OC43 and emergence of a novel genotype by natural recombination 2014-12-18 .txt text/plain 3950 222 55 METHODS: The full-length spike (S), RNA-dependent RNA polymerase (RdRp), and nucleocapsid (N) genes were amplified from each respiratory sample collected from 65 HCoV-OC43-positive patients between 2005 and 2012. In this study, we genotyped HCoV-OC43 by analyzing fulllength sequences of S, RdRp, N genes and viral genomes directly from respiratory samples collected from 65 HCoV-OC43 positive patients with acute respiratory tract infections (ARTIs) recruited from 2005 to 2012. The nucleotide sequence data of S, RdRp, N genes and viral genomes of HCoV-OC43 used in this study have been lodged in GenBank and the accession numbers are shown in Table S2 . To genotype the HCoV-OC43 samples, we constructed ML trees using the full-length sequences of S, RdRp and N genes amplified from the 65 respiratory samples of HCoV-OC43 positive patients in this study and compared them to those retrieved from GenBank (Fig. 1) . ./cache/cord-265772-diahoew3.txt ./txt/cord-265772-diahoew3.txt