id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-331929-rot2vgso	Piaserico, Stefano	REPLY TO: Interleukin-17: a potential therapeutic target in COVID-19	2020-06-29		.txt	text/plain	856	55	43	As observed in the paper by Mendoza, IL-17 is thought to play a key role in the immune dysregulation observed in COVID-19 and in other severe coronavirus-mediated respiratory syndromes, therefore its inhibition has been suggested to determine a better outcome in these patients. IL-17 has been shown to exert direct pro-fibrotic effects on fibroblasts isolated from mouse and human lung through the activation of NF-kB, promoting production of TGF-β and expression of αsmooth muscle actin and eventually leading to collagen deposition 5 . Pulmonary fibrosis in SARS patients may be the result of the high inflammatory burden related not only to the anti-viral immune response, but also to ventilatorinduced lung injury (VILI). Moreover, anticoagulant therapies have been shown to ameliorate lung fibrosis in both murine models and human patients. In conclusion, IL-17 appears to be involved in several processes which might be relevant in the pathogenesis of COVID-19-induced pulmonary fibrosis.	./cache/cord-331929-rot2vgso.txt	./txt/cord-331929-rot2vgso.txt