id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-332786-7b6wz6i7	Ha, Dat P.	The stress-inducible molecular chaperone GRP78 as potential therapeutic target for Coronavirus infection	2020-06-12		.txt	text/plain	1244	67	46	A recent report in this journal by Ibrahim and colleagues describing the potential binding interaction between SARS-CoV-2 spike protein and the host 78-kDa glucose regulated protein (GRP78) raised the possibility that GRP78 could be a facilitator for viral entry 1 and disruption of such interaction may be used to develop novel therapeutics specific against this virus 2 . In addition to its role in viral protein folding, GRP78 upregulation during viral replication could protect the virus-infected host cells from undergoing apoptosis since GRP78 is known to bind and maintain the ER-associated apoptotic machineries in their inactive forms and exert pro-survival effects especially under ER stress 3 . Conversely, the dependence of viruses on the ER and its key resident chaperone GRP78 for viral protein production and host cell survival could be the virus' Achilles heel and offers a unique opportunity for combating SARS-CoV-2 and other virus infections.	./cache/cord-332786-7b6wz6i7.txt	./txt/cord-332786-7b6wz6i7.txt