id sid tid token lemma pos cord-030594-xhp8kin0 1 1 key key JJ cord-030594-xhp8kin0 2 1 : : : cord-030594-xhp8kin0 2 2 cord-030594-xhp8kin0 cord-030594-xhp8kin0 NNS cord-030594-xhp8kin0 2 3 authors author NNS cord-030594-xhp8kin0 2 4 : : : cord-030594-xhp8kin0 3 1 nan nan NNP cord-030594-xhp8kin0 3 2 title title NN cord-030594-xhp8kin0 3 3 : : : cord-030594-xhp8kin0 4 1 Dear dear JJ cord-030594-xhp8kin0 4 2 the the DT cord-030594-xhp8kin0 4 3 Editor editor NN cord-030594-xhp8kin0 4 4 , , , cord-030594-xhp8kin0 4 5 date date NN cord-030594-xhp8kin0 4 6 : : : cord-030594-xhp8kin0 4 7 2020 2020 CD cord-030594-xhp8kin0 4 8 - - HYPH cord-030594-xhp8kin0 4 9 08 08 CD cord-030594-xhp8kin0 4 10 - - SYM cord-030594-xhp8kin0 4 11 19 19 CD cord-030594-xhp8kin0 4 12 journal journal NN cord-030594-xhp8kin0 4 13 : : : cord-030594-xhp8kin0 5 1 J J NNP cord-030594-xhp8kin0 5 2 Infect infect VB cord-030594-xhp8kin0 5 3 DOI DOI NNP cord-030594-xhp8kin0 5 4 : : : cord-030594-xhp8kin0 6 1 10.1016 10.1016 CD cord-030594-xhp8kin0 6 2 / / SYM cord-030594-xhp8kin0 6 3 j.jinf.2020.08.021 j.jinf.2020.08.021 CD cord-030594-xhp8kin0 7 1 sha sha NNP cord-030594-xhp8kin0 7 2 : : : cord-030594-xhp8kin0 8 1 f797b2075c84a88e9f853f2615955172a9aff916 f797b2075c84a88e9f853f2615955172a9aff916 NNP cord-030594-xhp8kin0 8 2 doc_id doc_id NNP cord-030594-xhp8kin0 8 3 : : : cord-030594-xhp8kin0 8 4 30594 30594 CD cord-030594-xhp8kin0 8 5 cord_uid cord_uid FW cord-030594-xhp8kin0 8 6 : : : cord-030594-xhp8kin0 9 1 xhp8kin0 xhp8kin0 NNP cord-030594-xhp8kin0 9 2 nan nan NNP cord-030594-xhp8kin0 9 3 Kunutsor Kunutsor NNP cord-030594-xhp8kin0 9 4 SK SK NNP cord-030594-xhp8kin0 9 5 et et NNP cord-030594-xhp8kin0 9 6 al al NNP cord-030594-xhp8kin0 9 7 . . NNP cord-030594-xhp8kin0 9 8 have have VBP cord-030594-xhp8kin0 9 9 written write VBN cord-030594-xhp8kin0 9 10 to to IN cord-030594-xhp8kin0 9 11 this this DT cord-030594-xhp8kin0 9 12 journal journal NN cord-030594-xhp8kin0 9 13 regarding regard VBG cord-030594-xhp8kin0 9 14 elevated elevated JJ cord-030594-xhp8kin0 9 15 admission admission NN cord-030594-xhp8kin0 9 16 levels level NNS cord-030594-xhp8kin0 9 17 of of IN cord-030594-xhp8kin0 9 18 markers marker NNS cord-030594-xhp8kin0 9 19 of of IN cord-030594-xhp8kin0 9 20 liver liver NN cord-030594-xhp8kin0 9 21 injury injury NN cord-030594-xhp8kin0 9 22 ( ( -LRB- cord-030594-xhp8kin0 9 23 alanine alanine JJ cord-030594-xhp8kin0 9 24 aminotransferase aminotransferase NN cord-030594-xhp8kin0 9 25 and and CC cord-030594-xhp8kin0 9 26 aspartate aspartate NN cord-030594-xhp8kin0 9 27 aminotransferase aminotransferase NN cord-030594-xhp8kin0 9 28 , , , cord-030594-xhp8kin0 9 29 gamma gamma NN cord-030594-xhp8kin0 9 30 - - HYPH cord-030594-xhp8kin0 9 31 glutamyltransferase glutamyltransferase JJ cord-030594-xhp8kin0 9 32 , , , cord-030594-xhp8kin0 9 33 alkaline alkaline JJ cord-030594-xhp8kin0 9 34 phosphatase phosphatase NN cord-030594-xhp8kin0 9 35 and and CC cord-030594-xhp8kin0 9 36 total total JJ cord-030594-xhp8kin0 9 37 bilirubin bilirubin NN cord-030594-xhp8kin0 9 38 ) ) -RRB- cord-030594-xhp8kin0 9 39 may may MD cord-030594-xhp8kin0 9 40 be be VB cord-030594-xhp8kin0 9 41 associated associate VBN cord-030594-xhp8kin0 9 42 with with IN cord-030594-xhp8kin0 9 43 progression progression NN cord-030594-xhp8kin0 9 44 to to IN cord-030594-xhp8kin0 9 45 severe severe JJ cord-030594-xhp8kin0 9 46 disease disease NN cord-030594-xhp8kin0 9 47 or or CC cord-030594-xhp8kin0 9 48 death death NN cord-030594-xhp8kin0 9 49 in in IN cord-030594-xhp8kin0 9 50 COVID-19 COVID-19 NNP cord-030594-xhp8kin0 9 51 . . . cord-030594-xhp8kin0 10 1 [ [ -LRB- cord-030594-xhp8kin0 10 2 1 1 CD cord-030594-xhp8kin0 10 3 ] ] -RRB- cord-030594-xhp8kin0 10 4 On on IN cord-030594-xhp8kin0 10 5 the the DT cord-030594-xhp8kin0 10 6 other other JJ cord-030594-xhp8kin0 10 7 hand hand NN cord-030594-xhp8kin0 10 8 , , , cord-030594-xhp8kin0 10 9 serum serum NN cord-030594-xhp8kin0 10 10 cholinesterase cholinesterase NN cord-030594-xhp8kin0 10 11 plays play VBZ cord-030594-xhp8kin0 10 12 an an DT cord-030594-xhp8kin0 10 13 important important JJ cord-030594-xhp8kin0 10 14 role role NN cord-030594-xhp8kin0 10 15 in in IN cord-030594-xhp8kin0 10 16 the the DT cord-030594-xhp8kin0 10 17 inflammatory inflammatory JJ cord-030594-xhp8kin0 10 18 response response NN cord-030594-xhp8kin0 10 19 and and CC cord-030594-xhp8kin0 10 20 may may MD cord-030594-xhp8kin0 10 21 be be VB cord-030594-xhp8kin0 10 22 associated associate VBN cord-030594-xhp8kin0 10 23 with with IN cord-030594-xhp8kin0 10 24 prognosis prognosis NN cord-030594-xhp8kin0 10 25 in in IN cord-030594-xhp8kin0 10 26 sepsis sepsis NN cord-030594-xhp8kin0 10 27 . . . cord-030594-xhp8kin0 11 1 [ [ -LRB- cord-030594-xhp8kin0 11 2 2 2 LS cord-030594-xhp8kin0 11 3 ] ] -RRB- cord-030594-xhp8kin0 11 4 [ [ -LRB- cord-030594-xhp8kin0 11 5 3 3 CD cord-030594-xhp8kin0 11 6 ] ] -RRB- cord-030594-xhp8kin0 11 7 [ [ -LRB- cord-030594-xhp8kin0 11 8 4 4 LS cord-030594-xhp8kin0 11 9 ] ] -RRB- cord-030594-xhp8kin0 11 10 We -PRON- PRP cord-030594-xhp8kin0 11 11 focused focus VBD cord-030594-xhp8kin0 11 12 on on IN cord-030594-xhp8kin0 11 13 the the DT cord-030594-xhp8kin0 11 14 similarities similarity NNS cord-030594-xhp8kin0 11 15 between between IN cord-030594-xhp8kin0 11 16 severe severe JJ cord-030594-xhp8kin0 11 17 COVID-19 covid-19 JJ cord-030594-xhp8kin0 11 18 pneumonia pneumonia NN cord-030594-xhp8kin0 11 19 and and CC cord-030594-xhp8kin0 11 20 sepsis sepsis NN cord-030594-xhp8kin0 11 21 . . . cord-030594-xhp8kin0 12 1 We -PRON- PRP cord-030594-xhp8kin0 12 2 examined examine VBD cord-030594-xhp8kin0 12 3 associations association NNS cord-030594-xhp8kin0 12 4 between between IN cord-030594-xhp8kin0 12 5 cholinesterase cholinesterase NN cord-030594-xhp8kin0 12 6 levels level NNS cord-030594-xhp8kin0 12 7 on on IN cord-030594-xhp8kin0 12 8 admission admission NN cord-030594-xhp8kin0 12 9 and and CC cord-030594-xhp8kin0 12 10 the the DT cord-030594-xhp8kin0 12 11 severity severity NN cord-030594-xhp8kin0 12 12 , , , cord-030594-xhp8kin0 12 13 and and CC cord-030594-xhp8kin0 12 14 mortality mortality NN cord-030594-xhp8kin0 12 15 of of IN cord-030594-xhp8kin0 12 16 patients patient NNS cord-030594-xhp8kin0 12 17 with with IN cord-030594-xhp8kin0 12 18 COVID-19 COVID-19 NNP cord-030594-xhp8kin0 12 19 pneumonia pneumonia NN cord-030594-xhp8kin0 12 20 , , , cord-030594-xhp8kin0 12 21 as as RB cord-030594-xhp8kin0 12 22 well well RB cord-030594-xhp8kin0 12 23 as as IN cord-030594-xhp8kin0 12 24 the the DT cord-030594-xhp8kin0 12 25 interaction interaction NN cord-030594-xhp8kin0 12 26 between between IN cord-030594-xhp8kin0 12 27 cholinesterase cholinesterase NN cord-030594-xhp8kin0 12 28 and and CC cord-030594-xhp8kin0 12 29 the the DT cord-030594-xhp8kin0 12 30 previously previously RB cord-030594-xhp8kin0 12 31 reported report VBN cord-030594-xhp8kin0 12 32 factors factor NNS cord-030594-xhp8kin0 12 33 of of IN cord-030594-xhp8kin0 12 34 severity severity NN cord-030594-xhp8kin0 12 35 and and CC cord-030594-xhp8kin0 12 36 mortality mortality NN cord-030594-xhp8kin0 12 37 . . . cord-030594-xhp8kin0 13 1 We -PRON- PRP cord-030594-xhp8kin0 13 2 included include VBD cord-030594-xhp8kin0 13 3 patients patient NNS cord-030594-xhp8kin0 13 4 who who WP cord-030594-xhp8kin0 13 5 had have VBD cord-030594-xhp8kin0 13 6 tested test VBN cord-030594-xhp8kin0 13 7 positive positive JJ cord-030594-xhp8kin0 13 8 for for IN cord-030594-xhp8kin0 13 9 severe severe JJ cord-030594-xhp8kin0 13 10 acute acute JJ cord-030594-xhp8kin0 13 11 respiratory respiratory JJ cord-030594-xhp8kin0 13 12 syndrome syndrome NN cord-030594-xhp8kin0 13 13 coronavirus coronavirus NN cord-030594-xhp8kin0 13 14 2 2 CD cord-030594-xhp8kin0 13 15 from from IN cord-030594-xhp8kin0 13 16 February February NNP cord-030594-xhp8kin0 13 17 to to IN cord-030594-xhp8kin0 13 18 May May NNP cord-030594-xhp8kin0 13 19 2020 2020 CD cord-030594-xhp8kin0 13 20 at at IN cord-030594-xhp8kin0 13 21 Yokohama Yokohama NNP cord-030594-xhp8kin0 13 22 City City NNP cord-030594-xhp8kin0 13 23 University University NNP cord-030594-xhp8kin0 13 24 Hospital Hospital NNP cord-030594-xhp8kin0 13 25 and and CC cord-030594-xhp8kin0 13 26 Yokohama Yokohama NNP cord-030594-xhp8kin0 13 27 City City NNP cord-030594-xhp8kin0 13 28 University University NNP cord-030594-xhp8kin0 13 29 Medical Medical NNP cord-030594-xhp8kin0 13 30 Center Center NNP cord-030594-xhp8kin0 13 31 . . . cord-030594-xhp8kin0 14 1 Ultimately ultimately RB cord-030594-xhp8kin0 14 2 , , , cord-030594-xhp8kin0 14 3 26 26 CD cord-030594-xhp8kin0 14 4 patients patient NNS cord-030594-xhp8kin0 14 5 were be VBD cord-030594-xhp8kin0 14 6 included include VBN cord-030594-xhp8kin0 14 7 in in IN cord-030594-xhp8kin0 14 8 the the DT cord-030594-xhp8kin0 14 9 study study NN cord-030594-xhp8kin0 14 10 . . . cord-030594-xhp8kin0 15 1 Outcomes outcome NNS cord-030594-xhp8kin0 15 2 were be VBD cord-030594-xhp8kin0 15 3 aggravation aggravation NN cord-030594-xhp8kin0 15 4 of of IN cord-030594-xhp8kin0 15 5 symptoms symptom NNS cord-030594-xhp8kin0 15 6 and and CC cord-030594-xhp8kin0 15 7 in in IN cord-030594-xhp8kin0 15 8 - - HYPH cord-030594-xhp8kin0 15 9 hospital hospital NN cord-030594-xhp8kin0 15 10 death death NN cord-030594-xhp8kin0 15 11 . . . cord-030594-xhp8kin0 16 1 The the DT cord-030594-xhp8kin0 16 2 clinical clinical JJ cord-030594-xhp8kin0 16 3 characteristics characteristic NNS cord-030594-xhp8kin0 16 4 of of IN cord-030594-xhp8kin0 16 5 the the DT cord-030594-xhp8kin0 16 6 patients patient NNS cord-030594-xhp8kin0 16 7 grouped group VBN cord-030594-xhp8kin0 16 8 by by IN cord-030594-xhp8kin0 16 9 severity severity NN cord-030594-xhp8kin0 16 10 are be VBP cord-030594-xhp8kin0 16 11 shown show VBN cord-030594-xhp8kin0 16 12 in in IN cord-030594-xhp8kin0 16 13 Table Table NNP cord-030594-xhp8kin0 16 14 1 1 CD cord-030594-xhp8kin0 16 15 . . . cord-030594-xhp8kin0 17 1 There there EX cord-030594-xhp8kin0 17 2 was be VBD cord-030594-xhp8kin0 17 3 no no DT cord-030594-xhp8kin0 17 4 significant significant JJ cord-030594-xhp8kin0 17 5 difference difference NN cord-030594-xhp8kin0 17 6 in in IN cord-030594-xhp8kin0 17 7 patient patient JJ cord-030594-xhp8kin0 17 8 characteristics characteristic NNS cord-030594-xhp8kin0 17 9 between between IN cord-030594-xhp8kin0 17 10 the the DT cord-030594-xhp8kin0 17 11 groups group NNS cord-030594-xhp8kin0 17 12 . . . cord-030594-xhp8kin0 18 1 Supplementary Supplementary NNP cord-030594-xhp8kin0 18 2 Materials material NNS cord-030594-xhp8kin0 18 3 1 1 CD cord-030594-xhp8kin0 18 4 shows show VBZ cord-030594-xhp8kin0 18 5 the the DT cord-030594-xhp8kin0 18 6 time time NN cord-030594-xhp8kin0 18 7 course course NN cord-030594-xhp8kin0 18 8 of of IN cord-030594-xhp8kin0 18 9 cholinesterase cholinesterase NN cord-030594-xhp8kin0 18 10 and and CC cord-030594-xhp8kin0 18 11 other other JJ cord-030594-xhp8kin0 18 12 factors factor NNS cord-030594-xhp8kin0 18 13 in in IN cord-030594-xhp8kin0 18 14 critically critically RB cord-030594-xhp8kin0 18 15 ill ill JJ cord-030594-xhp8kin0 18 16 patients patient NNS cord-030594-xhp8kin0 18 17 with with IN cord-030594-xhp8kin0 18 18 good good JJ cord-030594-xhp8kin0 18 19 outcome outcome NN cord-030594-xhp8kin0 18 20 and and CC cord-030594-xhp8kin0 18 21 death death NN cord-030594-xhp8kin0 18 22 . . . cord-030594-xhp8kin0 19 1 In in IN cord-030594-xhp8kin0 19 2 critically critically RB cord-030594-xhp8kin0 19 3 ill ill JJ cord-030594-xhp8kin0 19 4 patients patient NNS cord-030594-xhp8kin0 19 5 with with IN cord-030594-xhp8kin0 19 6 favorable favorable JJ cord-030594-xhp8kin0 19 7 outcome outcome NN cord-030594-xhp8kin0 19 8 , , , cord-030594-xhp8kin0 19 9 cholinesterase cholinesterase NN cord-030594-xhp8kin0 19 10 , , , cord-030594-xhp8kin0 19 11 lymphocytes lymphocyte NNS cord-030594-xhp8kin0 19 12 , , , cord-030594-xhp8kin0 19 13 albumin albumin NN cord-030594-xhp8kin0 19 14 , , , cord-030594-xhp8kin0 19 15 and and CC cord-030594-xhp8kin0 19 16 PaO pao NN cord-030594-xhp8kin0 19 17 2 2 CD cord-030594-xhp8kin0 19 18 /FiO /fio SYM cord-030594-xhp8kin0 19 19 2 2 CD cord-030594-xhp8kin0 19 20 ratio ratio NN cord-030594-xhp8kin0 19 21 decreased decrease VBD cord-030594-xhp8kin0 19 22 but but CC cord-030594-xhp8kin0 19 23 C c NN cord-030594-xhp8kin0 19 24 - - HYPH cord-030594-xhp8kin0 19 25 reactive reactive JJ cord-030594-xhp8kin0 19 26 protein protein NN cord-030594-xhp8kin0 19 27 increased increase VBD cord-030594-xhp8kin0 19 28 toward toward IN cord-030594-xhp8kin0 19 29 the the DT cord-030594-xhp8kin0 19 30 peak peak NN cord-030594-xhp8kin0 19 31 of of IN cord-030594-xhp8kin0 19 32 inflammation inflammation NN cord-030594-xhp8kin0 19 33 . . . cord-030594-xhp8kin0 20 1 Later later RB cord-030594-xhp8kin0 20 2 , , , cord-030594-xhp8kin0 20 3 C c NN cord-030594-xhp8kin0 20 4 - - HYPH cord-030594-xhp8kin0 20 5 reactive reactive JJ cord-030594-xhp8kin0 20 6 protein protein NN cord-030594-xhp8kin0 20 7 decreased decrease VBD cord-030594-xhp8kin0 20 8 with with IN cord-030594-xhp8kin0 20 9 improvement improvement NN cord-030594-xhp8kin0 20 10 in in IN cord-030594-xhp8kin0 20 11 inflammation inflammation NN cord-030594-xhp8kin0 20 12 , , , cord-030594-xhp8kin0 20 13 but but CC cord-030594-xhp8kin0 20 14 there there EX cord-030594-xhp8kin0 20 15 was be VBD cord-030594-xhp8kin0 20 16 a a DT cord-030594-xhp8kin0 20 17 tendency tendency NN cord-030594-xhp8kin0 20 18 for for IN cord-030594-xhp8kin0 20 19 cholinesterase cholinesterase NN cord-030594-xhp8kin0 20 20 , , , cord-030594-xhp8kin0 20 21 lymphocytes lymphocyte NNS cord-030594-xhp8kin0 20 22 , , , cord-030594-xhp8kin0 20 23 albumin albumin NN cord-030594-xhp8kin0 20 24 , , , cord-030594-xhp8kin0 20 25 and and CC cord-030594-xhp8kin0 20 26 PaO pao NN cord-030594-xhp8kin0 20 27 2 2 CD cord-030594-xhp8kin0 20 28 /FiO /fio SYM cord-030594-xhp8kin0 20 29 2 2 CD cord-030594-xhp8kin0 20 30 ratio ratio NN cord-030594-xhp8kin0 20 31 to to TO cord-030594-xhp8kin0 20 32 increase increase VB cord-030594-xhp8kin0 20 33 . . . cord-030594-xhp8kin0 21 1 In in IN cord-030594-xhp8kin0 21 2 contrast contrast NN cord-030594-xhp8kin0 21 3 , , , cord-030594-xhp8kin0 21 4 in in IN cord-030594-xhp8kin0 21 5 the the DT cord-030594-xhp8kin0 21 6 severely severely RB cord-030594-xhp8kin0 21 7 ill ill JJ cord-030594-xhp8kin0 21 8 patient patient NN cord-030594-xhp8kin0 21 9 who who WP cord-030594-xhp8kin0 21 10 died die VBD cord-030594-xhp8kin0 21 11 , , , cord-030594-xhp8kin0 21 12 C C NNP cord-030594-xhp8kin0 21 13 - - HYPH cord-030594-xhp8kin0 21 14 reactive reactive JJ cord-030594-xhp8kin0 21 15 protein protein NN cord-030594-xhp8kin0 21 16 poorly poorly RB cord-030594-xhp8kin0 21 17 decreased decrease VBD cord-030594-xhp8kin0 21 18 , , , cord-030594-xhp8kin0 21 19 and and CC cord-030594-xhp8kin0 21 20 cholinesterase cholinesterase NN cord-030594-xhp8kin0 21 21 , , , cord-030594-xhp8kin0 21 22 lymphocytes lymphocyte NNS cord-030594-xhp8kin0 21 23 , , , cord-030594-xhp8kin0 21 24 albumin albumin NN cord-030594-xhp8kin0 21 25 , , , cord-030594-xhp8kin0 21 26 and and CC cord-030594-xhp8kin0 21 27 PaO pao NN cord-030594-xhp8kin0 21 28 2 2 CD cord-030594-xhp8kin0 22 1 /FiO /FiO NFP cord-030594-xhp8kin0 22 2 2 2 CD cord-030594-xhp8kin0 22 3 ratio ratio NN cord-030594-xhp8kin0 22 4 were be VBD cord-030594-xhp8kin0 22 5 not not RB cord-030594-xhp8kin0 22 6 elevated elevated JJ cord-030594-xhp8kin0 22 7 . . . cord-030594-xhp8kin0 23 1 Our -PRON- PRP$ cord-030594-xhp8kin0 23 2 results result NNS cord-030594-xhp8kin0 23 3 demonstrate demonstrate VBP cord-030594-xhp8kin0 23 4 that that IN cord-030594-xhp8kin0 23 5 the the DT cord-030594-xhp8kin0 23 6 potential potential NN cord-030594-xhp8kin0 23 7 of of IN cord-030594-xhp8kin0 23 8 cholinesterase cholinesterase NN cord-030594-xhp8kin0 23 9 levels level NNS cord-030594-xhp8kin0 23 10 and and CC cord-030594-xhp8kin0 23 11 their -PRON- PRP$ cord-030594-xhp8kin0 23 12 interactions interaction NNS cord-030594-xhp8kin0 23 13 were be VBD cord-030594-xhp8kin0 23 14 significantly significantly RB cord-030594-xhp8kin0 23 15 associated associate VBN cord-030594-xhp8kin0 23 16 with with IN cord-030594-xhp8kin0 23 17 severity severity NN cord-030594-xhp8kin0 23 18 and and CC cord-030594-xhp8kin0 23 19 mortality mortality NN cord-030594-xhp8kin0 23 20 in in IN cord-030594-xhp8kin0 23 21 COVID-19 covid-19 JJ cord-030594-xhp8kin0 23 22 pneumonia pneumonia NN cord-030594-xhp8kin0 23 23 patients patient NNS cord-030594-xhp8kin0 23 24 . . . cord-030594-xhp8kin0 24 1 Cholinesterase Cholinesterase NNP cord-030594-xhp8kin0 24 2 is be VBZ cord-030594-xhp8kin0 24 3 an an DT cord-030594-xhp8kin0 24 4 enzyme enzyme NN cord-030594-xhp8kin0 24 5 produced produce VBN cord-030594-xhp8kin0 24 6 in in IN cord-030594-xhp8kin0 24 7 the the DT cord-030594-xhp8kin0 24 8 liver liver NN cord-030594-xhp8kin0 24 9 that that WDT cord-030594-xhp8kin0 24 10 hydrolyzes hydrolyze VBZ cord-030594-xhp8kin0 24 11 cholinesters cholinester NNS cord-030594-xhp8kin0 24 12 , , , cord-030594-xhp8kin0 24 13 and and CC cord-030594-xhp8kin0 24 14 measured measure VBN cord-030594-xhp8kin0 24 15 as as IN cord-030594-xhp8kin0 24 16 a a DT cord-030594-xhp8kin0 24 17 liver liver NN cord-030594-xhp8kin0 24 18 function function NN cord-030594-xhp8kin0 24 19 test test NN cord-030594-xhp8kin0 24 20 . . . cord-030594-xhp8kin0 25 1 Cholinesterase cholinesterase NN cord-030594-xhp8kin0 25 2 levels level NNS cord-030594-xhp8kin0 25 3 are be VBP cord-030594-xhp8kin0 25 4 high high JJ cord-030594-xhp8kin0 25 5 in in IN cord-030594-xhp8kin0 25 6 patients patient NNS cord-030594-xhp8kin0 25 7 with with IN cord-030594-xhp8kin0 25 8 nephrotic nephrotic JJ cord-030594-xhp8kin0 25 9 syndrome syndrome NN cord-030594-xhp8kin0 25 10 , , , cord-030594-xhp8kin0 25 11 diabetes diabetes NN cord-030594-xhp8kin0 25 12 , , , cord-030594-xhp8kin0 25 13 hyperthyroidism hyperthyroidism NN cord-030594-xhp8kin0 25 14 , , , cord-030594-xhp8kin0 25 15 fatty fatty JJ cord-030594-xhp8kin0 25 16 liver liver NN cord-030594-xhp8kin0 25 17 , , , cord-030594-xhp8kin0 25 18 dyslipidemia dyslipidemia NN cord-030594-xhp8kin0 25 19 , , , cord-030594-xhp8kin0 25 20 and and CC cord-030594-xhp8kin0 25 21 obesity obesity NN cord-030594-xhp8kin0 25 22 and and CC cord-030594-xhp8kin0 25 23 low low JJ cord-030594-xhp8kin0 25 24 in in IN cord-030594-xhp8kin0 25 25 patients patient NNS cord-030594-xhp8kin0 25 26 with with IN cord-030594-xhp8kin0 25 27 liver liver NN cord-030594-xhp8kin0 25 28 cirrhosis cirrhosis NN cord-030594-xhp8kin0 25 29 , , , cord-030594-xhp8kin0 25 30 hepatitis hepatitis NN cord-030594-xhp8kin0 25 31 , , , cord-030594-xhp8kin0 25 32 malignant malignant JJ cord-030594-xhp8kin0 25 33 tumor tumor NN cord-030594-xhp8kin0 25 34 , , , cord-030594-xhp8kin0 25 35 malnutrition malnutrition NN cord-030594-xhp8kin0 25 36 , , , cord-030594-xhp8kin0 25 37 sepsis sepsis NN cord-030594-xhp8kin0 25 38 , , , cord-030594-xhp8kin0 25 39 and and CC cord-030594-xhp8kin0 25 40 organophosphate organophosphate NN cord-030594-xhp8kin0 25 41 poisoning poisoning NN cord-030594-xhp8kin0 25 42 . . . cord-030594-xhp8kin0 26 1 [ [ -LRB- cord-030594-xhp8kin0 26 2 5 5 CD cord-030594-xhp8kin0 26 3 ] ] -RRB- cord-030594-xhp8kin0 27 1 Although although IN cord-030594-xhp8kin0 27 2 the the DT cord-030594-xhp8kin0 27 3 mechanism mechanism NN cord-030594-xhp8kin0 27 4 underlying underlie VBG cord-030594-xhp8kin0 27 5 cholinesterase cholinesterase NN cord-030594-xhp8kin0 27 6 reduction reduction NN cord-030594-xhp8kin0 27 7 in in IN cord-030594-xhp8kin0 27 8 sepsis sepsis NN cord-030594-xhp8kin0 27 9 has have VBZ cord-030594-xhp8kin0 27 10 not not RB cord-030594-xhp8kin0 27 11 yet yet RB cord-030594-xhp8kin0 27 12 been be VBN cord-030594-xhp8kin0 27 13 determined determine VBN cord-030594-xhp8kin0 27 14 , , , cord-030594-xhp8kin0 27 15 it -PRON- PRP cord-030594-xhp8kin0 27 16 is be VBZ cord-030594-xhp8kin0 27 17 thought think VBN cord-030594-xhp8kin0 27 18 to to TO cord-030594-xhp8kin0 27 19 be be VB cord-030594-xhp8kin0 27 20 affected affect VBN cord-030594-xhp8kin0 27 21 by by IN cord-030594-xhp8kin0 27 22 acute acute JJ cord-030594-xhp8kin0 27 23 - - HYPH cord-030594-xhp8kin0 27 24 phase phase NN cord-030594-xhp8kin0 27 25 infections infection NNS cord-030594-xhp8kin0 27 26 and and CC cord-030594-xhp8kin0 27 27 inflammatory inflammatory JJ cord-030594-xhp8kin0 27 28 processes process NNS cord-030594-xhp8kin0 27 29 . . . cord-030594-xhp8kin0 28 1 [ [ -LRB- cord-030594-xhp8kin0 28 2 6 6 LS cord-030594-xhp8kin0 28 3 ] ] -RRB- cord-030594-xhp8kin0 28 4 It -PRON- PRP cord-030594-xhp8kin0 28 5 has have VBZ cord-030594-xhp8kin0 28 6 been be VBN cord-030594-xhp8kin0 28 7 hypothesized hypothesize VBN cord-030594-xhp8kin0 28 8 that that IN cord-030594-xhp8kin0 28 9 cholinesterase cholinesterase NN cord-030594-xhp8kin0 28 10 synthesis synthesis NN cord-030594-xhp8kin0 28 11 decreases decrease VBZ cord-030594-xhp8kin0 28 12 owing owe VBG cord-030594-xhp8kin0 28 13 to to IN cord-030594-xhp8kin0 28 14 hepatic hepatic JJ cord-030594-xhp8kin0 28 15 dysfunction dysfunction NN cord-030594-xhp8kin0 28 16 with with IN cord-030594-xhp8kin0 28 17 disease disease NN cord-030594-xhp8kin0 28 18 progression progression NN cord-030594-xhp8kin0 28 19 , , , cord-030594-xhp8kin0 28 20 capillary capillary JJ cord-030594-xhp8kin0 28 21 permeability permeability NN cord-030594-xhp8kin0 28 22 enhancement enhancement NN cord-030594-xhp8kin0 28 23 , , , cord-030594-xhp8kin0 28 24 dilution dilution NN cord-030594-xhp8kin0 28 25 with with IN cord-030594-xhp8kin0 28 26 fluid fluid JJ cord-030594-xhp8kin0 28 27 challenges challenge NNS cord-030594-xhp8kin0 28 28 , , , cord-030594-xhp8kin0 28 29 cholinesterase cholinesterase NN cord-030594-xhp8kin0 28 30 catabolism catabolism NN cord-030594-xhp8kin0 28 31 enhancement enhancement NN cord-030594-xhp8kin0 28 32 , , , cord-030594-xhp8kin0 28 33 and and CC cord-030594-xhp8kin0 28 34 cholinesterase cholinesterase NN cord-030594-xhp8kin0 28 35 inhibition inhibition NN cord-030594-xhp8kin0 28 36 by by IN cord-030594-xhp8kin0 28 37 inflammatory inflammatory JJ cord-030594-xhp8kin0 28 38 mediators mediator NNS cord-030594-xhp8kin0 28 39 ( ( -LRB- cord-030594-xhp8kin0 28 40 cytokines cytokine NNS cord-030594-xhp8kin0 28 41 ) ) -RRB- cord-030594-xhp8kin0 28 42 . . . cord-030594-xhp8kin0 29 1 [ [ -LRB- cord-030594-xhp8kin0 29 2 7 7 CD cord-030594-xhp8kin0 29 3 ] ] -RRB- cord-030594-xhp8kin0 29 4 Levels level NNS cord-030594-xhp8kin0 29 5 of of IN cord-030594-xhp8kin0 29 6 " " `` cord-030594-xhp8kin0 29 7 positive positive JJ cord-030594-xhp8kin0 29 8 " " '' cord-030594-xhp8kin0 29 9 acute acute JJ cord-030594-xhp8kin0 29 10 - - HYPH cord-030594-xhp8kin0 29 11 phase phase NN cord-030594-xhp8kin0 29 12 proteins protein NNS cord-030594-xhp8kin0 29 13 such such JJ cord-030594-xhp8kin0 29 14 as as IN cord-030594-xhp8kin0 29 15 C C NNP cord-030594-xhp8kin0 29 16 - - HYPH cord-030594-xhp8kin0 29 17 reactive reactive JJ cord-030594-xhp8kin0 29 18 protein protein NN cord-030594-xhp8kin0 29 19 , , , cord-030594-xhp8kin0 29 20 amyloid amyloid NNP cord-030594-xhp8kin0 29 21 A A NNP cord-030594-xhp8kin0 29 22 , , , cord-030594-xhp8kin0 29 23 and and CC cord-030594-xhp8kin0 29 24 ferritin ferritin NN cord-030594-xhp8kin0 29 25 generally generally RB cord-030594-xhp8kin0 29 26 increase increase VBP cord-030594-xhp8kin0 29 27 in in IN cord-030594-xhp8kin0 29 28 patients patient NNS cord-030594-xhp8kin0 29 29 with with IN cord-030594-xhp8kin0 29 30 inflammatory inflammatory JJ cord-030594-xhp8kin0 29 31 diseases disease NNS cord-030594-xhp8kin0 29 32 . . . cord-030594-xhp8kin0 30 1 In in IN cord-030594-xhp8kin0 30 2 contrast contrast NN cord-030594-xhp8kin0 30 3 , , , cord-030594-xhp8kin0 30 4 levels level NNS cord-030594-xhp8kin0 30 5 of of IN cord-030594-xhp8kin0 30 6 " " `` cord-030594-xhp8kin0 30 7 negative negative JJ cord-030594-xhp8kin0 30 8 " " '' cord-030594-xhp8kin0 30 9 acute acute JJ cord-030594-xhp8kin0 30 10 - - HYPH cord-030594-xhp8kin0 30 11 phase phase NN cord-030594-xhp8kin0 30 12 proteins protein NNS cord-030594-xhp8kin0 30 13 such such JJ cord-030594-xhp8kin0 30 14 as as IN cord-030594-xhp8kin0 30 15 albumin albumin NN cord-030594-xhp8kin0 30 16 , , , cord-030594-xhp8kin0 30 17 prealbumin prealbumin NNP cord-030594-xhp8kin0 30 18 , , , cord-030594-xhp8kin0 30 19 and and CC cord-030594-xhp8kin0 30 20 transferrin transferrin NN cord-030594-xhp8kin0 30 21 decrease decrease NN cord-030594-xhp8kin0 30 22 in in IN cord-030594-xhp8kin0 30 23 response response NN cord-030594-xhp8kin0 30 24 to to IN cord-030594-xhp8kin0 30 25 inflammation inflammation NN cord-030594-xhp8kin0 30 26 and and CC cord-030594-xhp8kin0 30 27 increase increase NN cord-030594-xhp8kin0 30 28 during during IN cord-030594-xhp8kin0 30 29 the the DT cord-030594-xhp8kin0 30 30 recovery recovery NN cord-030594-xhp8kin0 30 31 period period NN cord-030594-xhp8kin0 30 32 . . . cord-030594-xhp8kin0 31 1 [ [ -LRB- cord-030594-xhp8kin0 31 2 2 2 CD cord-030594-xhp8kin0 31 3 , , , cord-030594-xhp8kin0 31 4 8 8 CD cord-030594-xhp8kin0 31 5 ] ] -RRB- cord-030594-xhp8kin0 31 6 Cholinesterase Cholinesterase NNP cord-030594-xhp8kin0 31 7 and and CC cord-030594-xhp8kin0 31 8 lymphocytes lymphocyte NNS cord-030594-xhp8kin0 31 9 behave behave VBP cord-030594-xhp8kin0 31 10 similar similar JJ cord-030594-xhp8kin0 31 11 to to IN cord-030594-xhp8kin0 31 12 the the DT cord-030594-xhp8kin0 31 13 " " `` cord-030594-xhp8kin0 31 14 negative negative JJ cord-030594-xhp8kin0 31 15 " " '' cord-030594-xhp8kin0 31 16 acute acute JJ cord-030594-xhp8kin0 31 17 - - HYPH cord-030594-xhp8kin0 31 18 phase phase NN cord-030594-xhp8kin0 31 19 proteins protein NNS cord-030594-xhp8kin0 31 20 in in IN cord-030594-xhp8kin0 31 21 response response NN cord-030594-xhp8kin0 31 22 to to IN cord-030594-xhp8kin0 31 23 inflammation inflammation NN cord-030594-xhp8kin0 31 24 . . . cord-030594-xhp8kin0 32 1 [ [ -LRB- cord-030594-xhp8kin0 32 2 9 9 CD cord-030594-xhp8kin0 32 3 , , , cord-030594-xhp8kin0 32 4 10 10 CD cord-030594-xhp8kin0 32 5 ] ] -RRB- cord-030594-xhp8kin0 32 6 Even even RB cord-030594-xhp8kin0 32 7 in in IN cord-030594-xhp8kin0 32 8 patients patient NNS cord-030594-xhp8kin0 32 9 with with IN cord-030594-xhp8kin0 32 10 COVID-19 COVID-19 NNP cord-030594-xhp8kin0 32 11 pneumonia pneumonia NN cord-030594-xhp8kin0 32 12 , , , cord-030594-xhp8kin0 32 13 amyloid amyloid NNP cord-030594-xhp8kin0 32 14 A A NNP cord-030594-xhp8kin0 32 15 , , , cord-030594-xhp8kin0 32 16 which which WDT cord-030594-xhp8kin0 32 17 is be VBZ cord-030594-xhp8kin0 32 18 classified classify VBN cord-030594-xhp8kin0 32 19 as as IN cord-030594-xhp8kin0 32 20 a a DT cord-030594-xhp8kin0 32 21 " " `` cord-030594-xhp8kin0 32 22 positive positive JJ cord-030594-xhp8kin0 32 23 " " '' cord-030594-xhp8kin0 32 24 acute acute JJ cord-030594-xhp8kin0 32 25 - - HYPH cord-030594-xhp8kin0 32 26 phase phase NN cord-030594-xhp8kin0 32 27 protein protein NN cord-030594-xhp8kin0 32 28 ; ; : cord-030594-xhp8kin0 32 29 albumin albumin NN cord-030594-xhp8kin0 32 30 , , , cord-030594-xhp8kin0 32 31 which which WDT cord-030594-xhp8kin0 32 32 is be VBZ cord-030594-xhp8kin0 32 33 classified classify VBN cord-030594-xhp8kin0 32 34 as as IN cord-030594-xhp8kin0 32 35 a a DT cord-030594-xhp8kin0 32 36 " " `` cord-030594-xhp8kin0 32 37 negative negative JJ cord-030594-xhp8kin0 32 38 " " '' cord-030594-xhp8kin0 32 39 acute acute JJ cord-030594-xhp8kin0 32 40 - - HYPH cord-030594-xhp8kin0 32 41 phase phase NN cord-030594-xhp8kin0 32 42 protein protein NN cord-030594-xhp8kin0 32 43 ; ; : cord-030594-xhp8kin0 32 44 and and CC cord-030594-xhp8kin0 32 45 lymphocytes lymphocyte NNS cord-030594-xhp8kin0 32 46 showing show VBG cord-030594-xhp8kin0 32 47 similar similar JJ cord-030594-xhp8kin0 32 48 reactions reaction NNS cord-030594-xhp8kin0 32 49 as as IN cord-030594-xhp8kin0 32 50 those those DT cord-030594-xhp8kin0 32 51 of of IN cord-030594-xhp8kin0 32 52 " " `` cord-030594-xhp8kin0 32 53 negative negative JJ cord-030594-xhp8kin0 32 54 " " '' cord-030594-xhp8kin0 32 55 acute acute JJ cord-030594-xhp8kin0 32 56 - - HYPH cord-030594-xhp8kin0 32 57 phase phase NN cord-030594-xhp8kin0 32 58 proteins protein NNS cord-030594-xhp8kin0 32 59 against against IN cord-030594-xhp8kin0 32 60 inflammation inflammation NN cord-030594-xhp8kin0 32 61 have have VBP cord-030594-xhp8kin0 32 62 been be VBN cord-030594-xhp8kin0 32 63 suggested suggest VBN cord-030594-xhp8kin0 32 64 to to TO cord-030594-xhp8kin0 32 65 be be VB cord-030594-xhp8kin0 32 66 related relate VBN cord-030594-xhp8kin0 32 67 to to IN cord-030594-xhp8kin0 32 68 severity severity NN cord-030594-xhp8kin0 32 69 . . . cord-030594-xhp8kin0 33 1 [ [ -LRB- cord-030594-xhp8kin0 33 2 4 4 CD cord-030594-xhp8kin0 33 3 ] ] -RRB- cord-030594-xhp8kin0 34 1 Our -PRON- PRP$ cord-030594-xhp8kin0 34 2 study study NN cord-030594-xhp8kin0 34 3 suggests suggest VBZ cord-030594-xhp8kin0 34 4 that that IN cord-030594-xhp8kin0 34 5 cholinesterase cholinesterase NN cord-030594-xhp8kin0 34 6 , , , cord-030594-xhp8kin0 34 7 which which WDT cord-030594-xhp8kin0 34 8 responds respond VBZ cord-030594-xhp8kin0 34 9 similar similar JJ cord-030594-xhp8kin0 34 10 to to IN cord-030594-xhp8kin0 34 11 the the DT cord-030594-xhp8kin0 34 12 " " `` cord-030594-xhp8kin0 34 13 negative negative JJ cord-030594-xhp8kin0 34 14 " " '' cord-030594-xhp8kin0 34 15 acute acute JJ cord-030594-xhp8kin0 34 16 - - HYPH cord-030594-xhp8kin0 34 17 phase phase NN cord-030594-xhp8kin0 34 18 proteins protein NNS cord-030594-xhp8kin0 34 19 in in IN cord-030594-xhp8kin0 34 20 response response NN cord-030594-xhp8kin0 34 21 to to IN cord-030594-xhp8kin0 34 22 inflammation inflammation NN cord-030594-xhp8kin0 34 23 , , , cord-030594-xhp8kin0 34 24 is be VBZ cord-030594-xhp8kin0 34 25 reduced reduce VBN cord-030594-xhp8kin0 34 26 even even RB cord-030594-xhp8kin0 34 27 in in IN cord-030594-xhp8kin0 34 28 the the DT cord-030594-xhp8kin0 34 29 acute acute JJ cord-030594-xhp8kin0 34 30 phase phase NN cord-030594-xhp8kin0 34 31 of of IN cord-030594-xhp8kin0 34 32 severe severe JJ cord-030594-xhp8kin0 34 33 COVID-19 covid-19 JJ cord-030594-xhp8kin0 34 34 pneumonia pneumonia NN cord-030594-xhp8kin0 34 35 . . . cord-030594-xhp8kin0 35 1 Following follow VBG cord-030594-xhp8kin0 35 2 the the DT cord-030594-xhp8kin0 35 3 changes change NNS cord-030594-xhp8kin0 35 4 in in IN cord-030594-xhp8kin0 35 5 cholinesterase cholinesterase NN cord-030594-xhp8kin0 35 6 over over IN cord-030594-xhp8kin0 35 7 time time NN cord-030594-xhp8kin0 35 8 , , , cord-030594-xhp8kin0 35 9 we -PRON- PRP cord-030594-xhp8kin0 35 10 found find VBD cord-030594-xhp8kin0 35 11 that that IN cord-030594-xhp8kin0 35 12 it -PRON- PRP cord-030594-xhp8kin0 35 13 decreased decrease VBD cord-030594-xhp8kin0 35 14 with with IN cord-030594-xhp8kin0 35 15 deterioration deterioration NN cord-030594-xhp8kin0 35 16 of of IN cord-030594-xhp8kin0 35 17 the the DT cord-030594-xhp8kin0 35 18 condition condition NN cord-030594-xhp8kin0 35 19 and and CC cord-030594-xhp8kin0 35 20 increased increase VBD cord-030594-xhp8kin0 35 21 with with IN cord-030594-xhp8kin0 35 22 improvement improvement NN cord-030594-xhp8kin0 35 23 . . . cord-030594-xhp8kin0 36 1 Cholinesterase cholinesterase NN cord-030594-xhp8kin0 36 2 level level NN cord-030594-xhp8kin0 36 3 on on IN cord-030594-xhp8kin0 36 4 admission admission NN cord-030594-xhp8kin0 36 5 is be VBZ cord-030594-xhp8kin0 36 6 suggested suggest VBN cord-030594-xhp8kin0 36 7 to to TO cord-030594-xhp8kin0 36 8 be be VB cord-030594-xhp8kin0 36 9 an an DT cord-030594-xhp8kin0 36 10 independent independent JJ cord-030594-xhp8kin0 36 11 predictor predictor NN cord-030594-xhp8kin0 36 12 of of IN cord-030594-xhp8kin0 36 13 severity severity NN cord-030594-xhp8kin0 36 14 and and CC cord-030594-xhp8kin0 36 15 mortality mortality NN cord-030594-xhp8kin0 36 16 for for IN cord-030594-xhp8kin0 36 17 COVID-19 COVID-19 NNP cord-030594-xhp8kin0 36 18 pneumonia pneumonia NN cord-030594-xhp8kin0 36 19 . . . cord-030594-xhp8kin0 37 1 Cholinesterase Cholinesterase NNP cord-030594-xhp8kin0 37 2 levels level NNS cord-030594-xhp8kin0 37 3 on on IN cord-030594-xhp8kin0 37 4 admission admission NN cord-030594-xhp8kin0 37 5 were be VBD cord-030594-xhp8kin0 37 6 significantly significantly RB cord-030594-xhp8kin0 37 7 lower low JJR cord-030594-xhp8kin0 37 8 in in IN cord-030594-xhp8kin0 37 9 the the DT cord-030594-xhp8kin0 37 10 severe severe JJ cord-030594-xhp8kin0 37 11 group group NN cord-030594-xhp8kin0 37 12 than than IN cord-030594-xhp8kin0 37 13 in in IN cord-030594-xhp8kin0 37 14 the the DT cord-030594-xhp8kin0 37 15 mild mild NN cord-030594-xhp8kin0 37 16 - - HYPH cord-030594-xhp8kin0 37 17 to to IN cord-030594-xhp8kin0 37 18 - - HYPH cord-030594-xhp8kin0 37 19 moderate moderate JJ cord-030594-xhp8kin0 37 20 group group NN cord-030594-xhp8kin0 37 21 , , , cord-030594-xhp8kin0 37 22 and and CC cord-030594-xhp8kin0 37 23 they -PRON- PRP cord-030594-xhp8kin0 37 24 were be VBD cord-030594-xhp8kin0 37 25 also also RB cord-030594-xhp8kin0 37 26 significantly significantly RB cord-030594-xhp8kin0 37 27 lower low JJR cord-030594-xhp8kin0 37 28 in in IN cord-030594-xhp8kin0 37 29 the the DT cord-030594-xhp8kin0 37 30 death death NN cord-030594-xhp8kin0 37 31 group group NN cord-030594-xhp8kin0 37 32 than than IN cord-030594-xhp8kin0 37 33 in in IN cord-030594-xhp8kin0 37 34 the the DT cord-030594-xhp8kin0 37 35 survival survival NN cord-030594-xhp8kin0 37 36 group group NN cord-030594-xhp8kin0 37 37 . . . cord-030594-xhp8kin0 38 1 Cholinesterase Cholinesterase NNP cord-030594-xhp8kin0 38 2 was be VBD cord-030594-xhp8kin0 38 3 comparable comparable JJ cord-030594-xhp8kin0 38 4 to to IN cord-030594-xhp8kin0 38 5 other other JJ cord-030594-xhp8kin0 38 6 markers marker NNS cord-030594-xhp8kin0 38 7 , , , cord-030594-xhp8kin0 38 8 such such JJ cord-030594-xhp8kin0 38 9 as as IN cord-030594-xhp8kin0 38 10 C C NNP cord-030594-xhp8kin0 38 11 - - HYPH cord-030594-xhp8kin0 38 12 reactive reactive JJ cord-030594-xhp8kin0 38 13 protein protein NN cord-030594-xhp8kin0 38 14 , , , cord-030594-xhp8kin0 38 15 PaO pao JJ cord-030594-xhp8kin0 38 16 2 2 CD cord-030594-xhp8kin0 38 17 /FiO /fio SYM cord-030594-xhp8kin0 38 18 2 2 CD cord-030594-xhp8kin0 38 19 ratio ratio NN cord-030594-xhp8kin0 38 20 , , , cord-030594-xhp8kin0 38 21 albumin albumin NN cord-030594-xhp8kin0 38 22 , , , cord-030594-xhp8kin0 38 23 ・Funding ・funde VBG cord-030594-xhp8kin0 38 24 This this DT cord-030594-xhp8kin0 38 25 research research NN cord-030594-xhp8kin0 38 26 did do VBD cord-030594-xhp8kin0 38 27 not not RB cord-030594-xhp8kin0 38 28 receive receive VB cord-030594-xhp8kin0 38 29 any any DT cord-030594-xhp8kin0 38 30 specific specific JJ cord-030594-xhp8kin0 38 31 grant grant NN cord-030594-xhp8kin0 38 32 from from IN cord-030594-xhp8kin0 38 33 funding fund VBG cord-030594-xhp8kin0 38 34 agencies agency NNS cord-030594-xhp8kin0 38 35 in in IN cord-030594-xhp8kin0 38 36 the the DT cord-030594-xhp8kin0 38 37 public public NN cord-030594-xhp8kin0 38 38 , , , cord-030594-xhp8kin0 38 39 commercial commercial JJ cord-030594-xhp8kin0 38 40 , , , cord-030594-xhp8kin0 38 41 or or CC cord-030594-xhp8kin0 38 42 not not RB cord-030594-xhp8kin0 38 43 - - HYPH cord-030594-xhp8kin0 38 44 for for IN cord-030594-xhp8kin0 38 45 - - HYPH cord-030594-xhp8kin0 38 46 profit profit NN cord-030594-xhp8kin0 38 47 sectors sector NNS cord-030594-xhp8kin0 38 48 . . . cord-030594-xhp8kin0 38 49 _SP cord-030594-xhp8kin0 39 1 Markers marker NNS cord-030594-xhp8kin0 39 2 of of IN cord-030594-xhp8kin0 39 3 liver liver NN cord-030594-xhp8kin0 39 4 injury injury NN cord-030594-xhp8kin0 39 5 and and CC cord-030594-xhp8kin0 39 6 clinical clinical JJ cord-030594-xhp8kin0 39 7 outcomes outcome NNS cord-030594-xhp8kin0 39 8 in in IN cord-030594-xhp8kin0 39 9 COVID-19 covid-19 CD cord-030594-xhp8kin0 39 10 patients patient NNS cord-030594-xhp8kin0 39 11 : : : cord-030594-xhp8kin0 40 1 A a DT cord-030594-xhp8kin0 40 2 systematic systematic JJ cord-030594-xhp8kin0 40 3 review review NN cord-030594-xhp8kin0 40 4 and and CC cord-030594-xhp8kin0 40 5 meta meta NN cord-030594-xhp8kin0 40 6 - - HYPH cord-030594-xhp8kin0 40 7 analysis analysis NN cord-030594-xhp8kin0 40 8 Butyrylcholinesterase Butyrylcholinesterase NNP cord-030594-xhp8kin0 40 9 as as IN cord-030594-xhp8kin0 40 10 a a DT cord-030594-xhp8kin0 40 11 prognostic prognostic JJ cord-030594-xhp8kin0 40 12 marker marker NN cord-030594-xhp8kin0 40 13 : : : cord-030594-xhp8kin0 40 14 a a DT cord-030594-xhp8kin0 40 15 review review NN cord-030594-xhp8kin0 40 16 of of IN cord-030594-xhp8kin0 40 17 the the DT cord-030594-xhp8kin0 40 18 literature literature NN cord-030594-xhp8kin0 41 1 A a DT cord-030594-xhp8kin0 41 2 sustained sustained JJ cord-030594-xhp8kin0 41 3 reduction reduction NN cord-030594-xhp8kin0 41 4 in in IN cord-030594-xhp8kin0 41 5 serum serum NN cord-030594-xhp8kin0 41 6 cholinesterase cholinesterase NN cord-030594-xhp8kin0 41 7 enzyme enzyme NN cord-030594-xhp8kin0 41 8 activity activity NN cord-030594-xhp8kin0 41 9 predicts predict VBZ cord-030594-xhp8kin0 41 10 patient patient JJ cord-030594-xhp8kin0 41 11 outcome outcome NN cord-030594-xhp8kin0 41 12 following follow VBG cord-030594-xhp8kin0 41 13 sepsis sepsis NN cord-030594-xhp8kin0 41 14 Value value NN cord-030594-xhp8kin0 41 15 of of IN cord-030594-xhp8kin0 41 16 serum serum NN cord-030594-xhp8kin0 41 17 cholinesterase cholinesterase NN cord-030594-xhp8kin0 41 18 in in IN cord-030594-xhp8kin0 41 19 the the DT cord-030594-xhp8kin0 41 20 prognosis prognosis NN cord-030594-xhp8kin0 41 21 of of IN cord-030594-xhp8kin0 41 22 septic septic JJ cord-030594-xhp8kin0 41 23 shock shock NN cord-030594-xhp8kin0 41 24 Serum serum NN cord-030594-xhp8kin0 41 25 cholinesterase cholinesterase NN cord-030594-xhp8kin0 41 26 is be VBZ cord-030594-xhp8kin0 41 27 an an DT cord-030594-xhp8kin0 41 28 excellent excellent JJ cord-030594-xhp8kin0 41 29 biomarker biomarker NN cord-030594-xhp8kin0 41 30 of of IN cord-030594-xhp8kin0 41 31 cirrhosis cirrhosis NN cord-030594-xhp8kin0 41 32 Acetylcholinesterase acetylcholinesterase NN cord-030594-xhp8kin0 41 33 and and CC cord-030594-xhp8kin0 41 34 butyrylcholinesterase butyrylcholinesterase NN cord-030594-xhp8kin0 41 35 as as IN cord-030594-xhp8kin0 41 36 possible possible JJ cord-030594-xhp8kin0 41 37 markers marker NNS cord-030594-xhp8kin0 41 38 of of IN cord-030594-xhp8kin0 41 39 low low JJ cord-030594-xhp8kin0 41 40 - - HYPH cord-030594-xhp8kin0 41 41 grade grade NN cord-030594-xhp8kin0 41 42 systemic systemic JJ cord-030594-xhp8kin0 41 43 inflammation inflammation NN cord-030594-xhp8kin0 41 44 Value value NN cord-030594-xhp8kin0 41 45 of of IN cord-030594-xhp8kin0 41 46 serum serum NN cord-030594-xhp8kin0 41 47 cholinesterase cholinesterase NN cord-030594-xhp8kin0 41 48 activity activity NN cord-030594-xhp8kin0 41 49 in in IN cord-030594-xhp8kin0 41 50 the the DT cord-030594-xhp8kin0 41 51 diagnosis diagnosis NN cord-030594-xhp8kin0 41 52 of of IN cord-030594-xhp8kin0 41 53 septic septic JJ cord-030594-xhp8kin0 41 54 shock shock NN cord-030594-xhp8kin0 41 55 due due IN cord-030594-xhp8kin0 41 56 to to IN cord-030594-xhp8kin0 41 57 bacterial bacterial JJ cord-030594-xhp8kin0 41 58 infections infection NNS cord-030594-xhp8kin0 41 59 Advances advance NNS cord-030594-xhp8kin0 41 60 in in IN cord-030594-xhp8kin0 41 61 understanding understanding NN cord-030594-xhp8kin0 41 62 and and CC cord-030594-xhp8kin0 41 63 assessing assess VBG cord-030594-xhp8kin0 41 64 malnutrition malnutrition NN cord-030594-xhp8kin0 41 65 Protein protein NN cord-030594-xhp8kin0 41 66 - - HYPH cord-030594-xhp8kin0 41 67 energy energy NN cord-030594-xhp8kin0 41 68 malnutrition malnutrition NN cord-030594-xhp8kin0 41 69 : : : cord-030594-xhp8kin0 41 70 its -PRON- PRP$ cord-030594-xhp8kin0 41 71 effects effect NNS cord-030594-xhp8kin0 41 72 on on IN cord-030594-xhp8kin0 41 73 4 4 CD cord-030594-xhp8kin0 41 74 metabolic metabolic JJ cord-030594-xhp8kin0 41 75 parameters parameter NNS cord-030594-xhp8kin0 41 76 Plasma plasma NN cord-030594-xhp8kin0 41 77 esterases esterase NNS cord-030594-xhp8kin0 41 78 and and CC cord-030594-xhp8kin0 41 79 inflammation inflammation NN cord-030594-xhp8kin0 41 80 in in IN cord-030594-xhp8kin0 41 81 ageing age VBG cord-030594-xhp8kin0 41 82 and and CC cord-030594-xhp8kin0 41 83 frailty frailty NN cord-030594-xhp8kin0 41 84 Median median JJ cord-030594-xhp8kin0 41 85 laboratory laboratory NN cord-030594-xhp8kin0 41 86 values value NNS cord-030594-xhp8kin0 41 87 ( ( -LRB- cord-030594-xhp8kin0 41 88 IQR iqr NN cord-030594-xhp8kin0 41 89 ) ) -RRB- cord-030594-xhp8kin0 41 90 ChE ChE NNP cord-030594-xhp8kin0 42 1 ( ( -LRB- cord-030594-xhp8kin0 42 2 U U NNP cord-030594-xhp8kin0 42 3 / / SYM cord-030594-xhp8kin0 42 4 L l NN cord-030594-xhp8kin0 42 5 ) ) -RRB- cord-030594-xhp8kin0 43 1 * * NFP cord-030594-xhp8kin0 43 2 The the DT cord-030594-xhp8kin0 43 3 mild mild JJ cord-030594-xhp8kin0 43 4 - - HYPH cord-030594-xhp8kin0 43 5 to to IN cord-030594-xhp8kin0 43 6 - - HYPH cord-030594-xhp8kin0 43 7 moderate moderate JJ cord-030594-xhp8kin0 43 8 group group NN cord-030594-xhp8kin0 43 9 was be VBD cord-030594-xhp8kin0 43 10 defined define VBN cord-030594-xhp8kin0 43 11 based base VBN cord-030594-xhp8kin0 43 12 on on IN cord-030594-xhp8kin0 43 13 the the DT cord-030594-xhp8kin0 43 14 need need NN cord-030594-xhp8kin0 43 15 for for IN cord-030594-xhp8kin0 43 16 oxygen oxygen NN cord-030594-xhp8kin0 43 17 inhalation inhalation NN cord-030594-xhp8kin0 43 18 or or CC cord-030594-xhp8kin0 43 19 no no DT cord-030594-xhp8kin0 43 20 oxygen oxygen NN cord-030594-xhp8kin0 43 21 inhalation inhalation NN cord-030594-xhp8kin0 44 1 The the DT cord-030594-xhp8kin0 44 2 severe severe JJ cord-030594-xhp8kin0 44 3 group group NN cord-030594-xhp8kin0 44 4 was be VBD cord-030594-xhp8kin0 44 5 defined define VBN cord-030594-xhp8kin0 44 6 as as IN cord-030594-xhp8kin0 44 7 having have VBG cord-030594-xhp8kin0 44 8 a a DT cord-030594-xhp8kin0 44 9 respiratory respiratory JJ cord-030594-xhp8kin0 44 10 condition condition NN cord-030594-xhp8kin0 44 11 requiring require VBG cord-030594-xhp8kin0 44 12 ventilator ventilator NN cord-030594-xhp8kin0 44 13 management management NN cord-030594-xhp8kin0 44 14 ( ( -LRB- cord-030594-xhp8kin0 44 15 PaO2 PaO2 NNS cord-030594-xhp8kin0 44 16 / / SYM cord-030594-xhp8kin0 44 17 FiO2 FiO2 NNP cord-030594-xhp8kin0 44 18 ratio ratio NN cord-030594-xhp8kin0 45 1 < < XX cord-030594-xhp8kin0 45 2 200 200 CD cord-030594-xhp8kin0 45 3 mmHg mmHg NNS cord-030594-xhp8kin0 45 4 to to IN cord-030594-xhp8kin0 45 5 respiratory respiratory JJ cord-030594-xhp8kin0 45 6 rate rate NN cord-030594-xhp8kin0 45 7 > > XX cord-030594-xhp8kin0 45 8 30 30 CD cord-030594-xhp8kin0 45 9 /min /min NFP cord-030594-xhp8kin0 45 10 ) ) -RRB-