id author title date pages extension mime words sentences flesch summary cache txt cord-003567-h8uq5z8b Crank, Michelle C Preparing for the Next Influenza Pandemic: The Development of a Universal Influenza Vaccine 2019-04-15 .txt text/plain 1557 92 38 This issue of The Journal of Infectious Diseases was motivated by the confluence of the 1918 influenza pandemic centenary and the new opportunities afforded by technological advances and breakthroughs along with the improved understanding of influenza biology. 7. Defining the importance of including specific antigenic targets, such as the head or stem domains of hemagglutinin, neuraminidase, or the M2 ectodomain in universal vaccines, and determining whether they are more effective when used in combination or alone could be accomplished through both vaccine protection and natural history studies that provide a better understanding of protective immunity [9] [10] [11] [12] . Improving the characterization of and expanding the reagents for these models would not only benefit influenza vaccine development but would also provide answers to immunological questions relevant to other respiratory virus infections and emerging infectious diseases in general. ./cache/cord-003567-h8uq5z8b.txt ./txt/cord-003567-h8uq5z8b.txt