id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-266695-ktbgm0p9	Dawson, Liza	SARS-CoV-2 Human Challenge Trials: Too Risky, Too Soon	2020-06-04		.txt	text/plain	1452	109	50	have recently argued that researchers should consider conducting SARS-CoV-2 human challenge studies to hasten vaccine development [1] . However, we disagree that SARS-CoV-2 challenge studies are ethically appropriate at this time, for three reasons: 1) current scientific knowledge of SARS-CoV-2 infection is insufficient to manage risks; 2) autonomous decision-making, while necessary, does not override concerns about risk; and 3) undertaking challenge studies now would imperil confidence in the research enterprise, potentially undermining the global response to the COVID-19 pandemic. Current scientific knowledge is insufficient to manage the risks of severe disease or death of volunteers in SARS-CoV-2 human challenge studies, especially in terms of selecting low risk volunteers [2] . It is not obvious that the possible benefits of developing a successful vaccine in less time justify the risks SARS-CoV-2 challenge studies, as Eyal and colleagues suggest. However, conducting SARS-CoV-2 human challenge trials now unjustifiably threatens both the well-being of volunteers and confidence in the research enterprise.	./cache/cord-266695-ktbgm0p9.txt	./txt/cord-266695-ktbgm0p9.txt