id	sid	tid	token	lemma	pos
cord-011710-rz23ozxb	1	1	key	key	JJ
cord-011710-rz23ozxb	2	1	:	:	:
cord-011710-rz23ozxb	2	2	cord-011710-rz23ozxb	cord-011710-rz23ozxb	NN
cord-011710-rz23ozxb	2	3	authors	author	NNS
cord-011710-rz23ozxb	2	4	:	:	:
cord-011710-rz23ozxb	2	5	Aoki	Aoki	NNP
cord-011710-rz23ozxb	2	6	,	,	,
cord-011710-rz23ozxb	2	7	Fred	Fred	NNP
cord-011710-rz23ozxb	2	8	Y.	Y.	NNP
cord-011710-rz23ozxb	2	9	;	;	:
cord-011710-rz23ozxb	2	10	Hayden	Hayden	NNP
cord-011710-rz23ozxb	2	11	,	,	,
cord-011710-rz23ozxb	3	1	Frederick	Frederick	NNP
cord-011710-rz23ozxb	3	2	G.	G.	NNP
cord-011710-rz23ozxb	3	3	title	title	NN
cord-011710-rz23ozxb	3	4	:	:	:
cord-011710-rz23ozxb	3	5	The	the	DT
cord-011710-rz23ozxb	3	6	Beneficial	beneficial	JJ
cord-011710-rz23ozxb	3	7	Effects	effect	NNS
cord-011710-rz23ozxb	3	8	of	of	IN
cord-011710-rz23ozxb	3	9	Neuraminidase	Neuraminidase	NNP
cord-011710-rz23ozxb	3	10	Inhibitor	Inhibitor	NNP
cord-011710-rz23ozxb	3	11	Drug	Drug	NNP
cord-011710-rz23ozxb	3	12	Therapy	Therapy	NNP
cord-011710-rz23ozxb	3	13	on	on	IN
cord-011710-rz23ozxb	3	14	Severe	severe	JJ
cord-011710-rz23ozxb	3	15	Patient	patient	NN
cord-011710-rz23ozxb	3	16	Outcomes	Outcomes	NNPS
cord-011710-rz23ozxb	3	17	During	during	IN
cord-011710-rz23ozxb	3	18	the	the	DT
cord-011710-rz23ozxb	3	19	2009–2010	2009–2010	CD
cord-011710-rz23ozxb	3	20	Influenza	Influenza	NNP
cord-011710-rz23ozxb	3	21	A	A	NNP
cord-011710-rz23ozxb	3	22	Virus	Virus	NNP
cord-011710-rz23ozxb	3	23	Subtype	Subtype	NNP
cord-011710-rz23ozxb	3	24	H1N1	H1N1	NNP
cord-011710-rz23ozxb	3	25	Pandemic	Pandemic	NNP
cord-011710-rz23ozxb	3	26	date	date	NN
cord-011710-rz23ozxb	3	27	:	:	:
cord-011710-rz23ozxb	3	28	2013	2013	CD
cord-011710-rz23ozxb	3	29	-	-	SYM
cord-011710-rz23ozxb	3	30	02	02	CD
cord-011710-rz23ozxb	3	31	-	-	SYM
cord-011710-rz23ozxb	3	32	15	15	CD
cord-011710-rz23ozxb	3	33	journal	journal	NN
cord-011710-rz23ozxb	3	34	:	:	:
cord-011710-rz23ozxb	4	1	J	J	NNP
cord-011710-rz23ozxb	4	2	Infect	infect	VBP
cord-011710-rz23ozxb	4	3	Dis	Dis	NNP
cord-011710-rz23ozxb	4	4	DOI	doi	NN
cord-011710-rz23ozxb	4	5	:	:	:
cord-011710-rz23ozxb	4	6	10.1093	10.1093	CD
cord-011710-rz23ozxb	4	7	/	/	SYM
cord-011710-rz23ozxb	4	8	infdis	infdis	NNP
cord-011710-rz23ozxb	4	9	/	/	SYM
cord-011710-rz23ozxb	4	10	jis727	jis727	NNP
cord-011710-rz23ozxb	4	11	sha	sha	NNP
cord-011710-rz23ozxb	4	12	:	:	:
cord-011710-rz23ozxb	5	1	cb53fc31025a98715cdfa73c4951086d414b2c9d	cb53fc31025a98715cdfa73c4951086d414b2c9d	NNP
cord-011710-rz23ozxb	5	2	doc_id	doc_id	NNP
cord-011710-rz23ozxb	5	3	:	:	:
cord-011710-rz23ozxb	6	1	11710	11710	CD
cord-011710-rz23ozxb	6	2	cord_uid	cord_uid	NNS
cord-011710-rz23ozxb	6	3	:	:	:
cord-011710-rz23ozxb	6	4	rz23ozxb	rz23ozxb	NNP
cord-011710-rz23ozxb	6	5	nan	nan	NNP
cord-011710-rz23ozxb	7	1	Elsewhere	elsewhere	RB
cord-011710-rz23ozxb	7	2	in	in	IN
cord-011710-rz23ozxb	7	3	the	the	DT
cord-011710-rz23ozxb	7	4	pages	page	NNS
cord-011710-rz23ozxb	7	5	of	of	IN
cord-011710-rz23ozxb	7	6	the	the	DT
cord-011710-rz23ozxb	7	7	Journal	Journal	NNP
cord-011710-rz23ozxb	7	8	,	,	,
cord-011710-rz23ozxb	7	9	Muthuri	Muthuri	NNP
cord-011710-rz23ozxb	7	10	et	et	NNP
cord-011710-rz23ozxb	7	11	al	al	NNP
cord-011710-rz23ozxb	7	12	answer	answer	VB
cord-011710-rz23ozxb	7	13	a	a	DT
cord-011710-rz23ozxb	7	14	question	question	NN
cord-011710-rz23ozxb	7	15	of	of	IN
cord-011710-rz23ozxb	7	16	substantial	substantial	JJ
cord-011710-rz23ozxb	7	17	contemporary	contemporary	JJ
cord-011710-rz23ozxb	7	18	importance	importance	NN
cord-011710-rz23ozxb	7	19	to	to	IN
cord-011710-rz23ozxb	7	20	clinicians	clinician	NNS
cord-011710-rz23ozxb	7	21	and	and	CC
cord-011710-rz23ozxb	7	22	public	public	JJ
cord-011710-rz23ozxb	7	23	health	health	NN
cord-011710-rz23ozxb	7	24	decision	decision	NN
cord-011710-rz23ozxb	7	25	makers	maker	NNS
cord-011710-rz23ozxb	7	26	,	,	,
cord-011710-rz23ozxb	7	27	namely	namely	RB
cord-011710-rz23ozxb	7	28	,	,	,
cord-011710-rz23ozxb	7	29	whether	whether	IN
cord-011710-rz23ozxb	7	30	antiviral	antiviral	JJ
cord-011710-rz23ozxb	7	31	therapy	therapy	NN
cord-011710-rz23ozxb	7	32	for	for	IN
cord-011710-rz23ozxb	7	33	influenza	influenza	NN
cord-011710-rz23ozxb	7	34	can	can	MD
cord-011710-rz23ozxb	7	35	reduce	reduce	VB
cord-011710-rz23ozxb	7	36	severe	severe	JJ
cord-011710-rz23ozxb	7	37	outcomes	outcome	NNS
cord-011710-rz23ozxb	7	38	of	of	IN
cord-011710-rz23ozxb	7	39	the	the	DT
cord-011710-rz23ozxb	7	40	disease	disease	NN
cord-011710-rz23ozxb	7	41	in	in	IN
cord-011710-rz23ozxb	7	42	hospitalized	hospitalize	VBN
cord-011710-rz23ozxb	7	43	patients	patient	NNS
cord-011710-rz23ozxb	7	44	[	[	-LRB-
cord-011710-rz23ozxb	7	45	1	1	CD
cord-011710-rz23ozxb	7	46	]	]	-RRB-
cord-011710-rz23ozxb	7	47	.	.	.
cord-011710-rz23ozxb	8	1	In	in	IN
cord-011710-rz23ozxb	8	2	a	a	DT
cord-011710-rz23ozxb	8	3	welcome	welcome	JJ
cord-011710-rz23ozxb	8	4	affirmation	affirmation	NN
cord-011710-rz23ozxb	8	5	of	of	IN
cord-011710-rz23ozxb	8	6	the	the	DT
cord-011710-rz23ozxb	8	7	effectiveness	effectiveness	NN
cord-011710-rz23ozxb	8	8	of	of	IN
cord-011710-rz23ozxb	8	9	neuraminidase	neuraminidase	JJ
cord-011710-rz23ozxb	8	10	inhibitor	inhibitor	NN
cord-011710-rz23ozxb	8	11	(	(	-LRB-
cord-011710-rz23ozxb	8	12	NAI	NAI	NNP
cord-011710-rz23ozxb	8	13	)	)	-RRB-
cord-011710-rz23ozxb	8	14	treatment	treatment	NN
cord-011710-rz23ozxb	8	15	,	,	,
cord-011710-rz23ozxb	8	16	they	-PRON-	PRP
cord-011710-rz23ozxb	8	17	report	report	VBP
cord-011710-rz23ozxb	8	18	that	that	IN
cord-011710-rz23ozxb	8	19	a	a	DT
cord-011710-rz23ozxb	8	20	meta	meta	JJ
cord-011710-rz23ozxb	8	21	-	-	HYPH
cord-011710-rz23ozxb	8	22	analysis	analysis	NN
cord-011710-rz23ozxb	8	23	of	of	IN
cord-011710-rz23ozxb	8	24	90	90	CD
cord-011710-rz23ozxb	8	25	observational	observational	JJ
cord-011710-rz23ozxb	8	26	studies	study	NNS
cord-011710-rz23ozxb	8	27	involving	involve	VBG
cord-011710-rz23ozxb	8	28	34	34	CD
cord-011710-rz23ozxb	8	29	895	895	CD
cord-011710-rz23ozxb	8	30	patients	patient	NNS
cord-011710-rz23ozxb	8	31	of	of	IN
cord-011710-rz23ozxb	8	32	whom	whom	WP
cord-011710-rz23ozxb	8	33	85	85	CD
cord-011710-rz23ozxb	8	34	%	%	NN
cord-011710-rz23ozxb	8	35	had	have	VBD
cord-011710-rz23ozxb	8	36	laboratory	laboratory	NN
cord-011710-rz23ozxb	8	37	-	-	HYPH
cord-011710-rz23ozxb	8	38	confirmed	confirm	VBN
cord-011710-rz23ozxb	8	39	2009	2009	CD
cord-011710-rz23ozxb	9	1	pandemic	pandemic	NN
cord-011710-rz23ozxb	9	2	influenza	influenza	NN
cord-011710-rz23ozxb	9	3	A	a	DT
cord-011710-rz23ozxb	9	4	virus	virus	NN
cord-011710-rz23ozxb	9	5	subtype	subtype	NN
cord-011710-rz23ozxb	10	1	H1N1	H1N1	NNP
cord-011710-rz23ozxb	10	2	(	(	-LRB-
cord-011710-rz23ozxb	10	3	A	a	DT
cord-011710-rz23ozxb	10	4	[	[	-LRB-
cord-011710-rz23ozxb	10	5	H1N1]pdm09	H1N1]pdm09	NNP
cord-011710-rz23ozxb	10	6	)	)	-RRB-
cord-011710-rz23ozxb	10	7	infection	infection	NN
cord-011710-rz23ozxb	10	8	revealed	reveal	VBD
cord-011710-rz23ozxb	10	9	that	that	IN
cord-011710-rz23ozxb	10	10	antiviral	antiviral	JJ
cord-011710-rz23ozxb	10	11	therapy	therapy	NN
cord-011710-rz23ozxb	10	12	,	,	,
cord-011710-rz23ozxb	10	13	principally	principally	RB
cord-011710-rz23ozxb	10	14	oseltamivir	oseltamivir	NNP
cord-011710-rz23ozxb	10	15	,	,	,
cord-011710-rz23ozxb	10	16	initiated	initiate	VBD
cord-011710-rz23ozxb	10	17	within	within	IN
cord-011710-rz23ozxb	10	18	48	48	CD
cord-011710-rz23ozxb	10	19	hours	hour	NNS
cord-011710-rz23ozxb	10	20	of	of	IN
cord-011710-rz23ozxb	10	21	symptom	symptom	NN
cord-011710-rz23ozxb	10	22	onset	onset	NN
cord-011710-rz23ozxb	10	23	reduced	reduce	VBD
cord-011710-rz23ozxb	10	24	the	the	DT
cord-011710-rz23ozxb	10	25	likelihood	likelihood	NN
cord-011710-rz23ozxb	10	26	of	of	IN
cord-011710-rz23ozxb	10	27	severe	severe	JJ
cord-011710-rz23ozxb	10	28	outcomes	outcome	NNS
cord-011710-rz23ozxb	10	29	,	,	,
cord-011710-rz23ozxb	10	30	namely	namely	RB
cord-011710-rz23ozxb	10	31	admission	admission	NN
cord-011710-rz23ozxb	10	32	to	to	IN
cord-011710-rz23ozxb	10	33	a	a	DT
cord-011710-rz23ozxb	10	34	critical	critical	JJ
cord-011710-rz23ozxb	10	35	care	care	NN
cord-011710-rz23ozxb	10	36	unit	unit	NN
cord-011710-rz23ozxb	10	37	or	or	CC
cord-011710-rz23ozxb	10	38	death	death	NN
cord-011710-rz23ozxb	10	39	,	,	,
cord-011710-rz23ozxb	10	40	by	by	IN
cord-011710-rz23ozxb	10	41	49%-65	49%-65	CD
cord-011710-rz23ozxb	10	42	%	%	NN
cord-011710-rz23ozxb	10	43	.	.	.
cord-011710-rz23ozxb	11	1	The	the	DT
cord-011710-rz23ozxb	11	2	strength	strength	NN
cord-011710-rz23ozxb	11	3	of	of	IN
cord-011710-rz23ozxb	11	4	the	the	DT
cord-011710-rz23ozxb	11	5	conclusions	conclusion	NNS
cord-011710-rz23ozxb	11	6	resides	reside	VBZ
cord-011710-rz23ozxb	11	7	both	both	DT
cord-011710-rz23ozxb	11	8	in	in	IN
cord-011710-rz23ozxb	11	9	the	the	DT
cord-011710-rz23ozxb	11	10	methodologic	methodologic	JJ
cord-011710-rz23ozxb	11	11	rigor	rigor	NN
cord-011710-rz23ozxb	11	12	applied	apply	VBN
cord-011710-rz23ozxb	11	13	to	to	IN
cord-011710-rz23ozxb	11	14	the	the	DT
cord-011710-rz23ozxb	11	15	meta	meta	NNP
cord-011710-rz23ozxb	11	16	-	-	HYPH
cord-011710-rz23ozxb	11	17	analysis	analysis	NN
cord-011710-rz23ozxb	11	18	of	of	IN
cord-011710-rz23ozxb	11	19	the	the	DT
cord-011710-rz23ozxb	11	20	component	component	NN
cord-011710-rz23ozxb	11	21	studies	study	NNS
cord-011710-rz23ozxb	11	22	and	and	CC
cord-011710-rz23ozxb	11	23	the	the	DT
cord-011710-rz23ozxb	11	24	large	large	JJ
cord-011710-rz23ozxb	11	25	numbers	number	NNS
cord-011710-rz23ozxb	11	26	of	of	IN
cord-011710-rz23ozxb	11	27	studies	study	NNS
cord-011710-rz23ozxb	11	28	and	and	CC
cord-011710-rz23ozxb	11	29	patients	patient	NNS
cord-011710-rz23ozxb	11	30	analyzed	analyze	VBD
cord-011710-rz23ozxb	11	31	.	.	.
cord-011710-rz23ozxb	12	1	This	this	DT
cord-011710-rz23ozxb	12	2	finding	finding	NN
cord-011710-rz23ozxb	12	3	confirms	confirm	VBZ
cord-011710-rz23ozxb	12	4	earlier	early	JJR
cord-011710-rz23ozxb	12	5	reports	report	NNS
cord-011710-rz23ozxb	12	6	of	of	IN
cord-011710-rz23ozxb	12	7	reduced	reduce	VBN
cord-011710-rz23ozxb	12	8	mortality	mortality	NN
cord-011710-rz23ozxb	12	9	with	with	IN
cord-011710-rz23ozxb	12	10	oseltamivir	oseltamivir	NN
cord-011710-rz23ozxb	12	11	therapy	therapy	NN
cord-011710-rz23ozxb	12	12	in	in	IN
cord-011710-rz23ozxb	12	13	those	those	DT
cord-011710-rz23ozxb	12	14	hospitalized	hospitalize	VBN
cord-011710-rz23ozxb	12	15	with	with	IN
cord-011710-rz23ozxb	12	16	seasonal	seasonal	JJ
cord-011710-rz23ozxb	12	17	[	[	-LRB-
cord-011710-rz23ozxb	12	18	2	2	CD
cord-011710-rz23ozxb	12	19	]	]	-RRB-
cord-011710-rz23ozxb	12	20	or	or	CC
cord-011710-rz23ozxb	12	21	avian	avian	JJ
cord-011710-rz23ozxb	12	22	A(H5N1	A(H5N1	NNP
cord-011710-rz23ozxb	12	23	)	)	-RRB-
cord-011710-rz23ozxb	12	24	[	[	-LRB-
cord-011710-rz23ozxb	12	25	3	3	CD
cord-011710-rz23ozxb	12	26	,	,	,
cord-011710-rz23ozxb	12	27	4	4	CD
cord-011710-rz23ozxb	12	28	]	]	-RRB-
cord-011710-rz23ozxb	12	29	influenza	influenza	NN
cord-011710-rz23ozxb	12	30	.	.	.
cord-011710-rz23ozxb	13	1	The	the	DT
cord-011710-rz23ozxb	13	2	findings	finding	NNS
cord-011710-rz23ozxb	13	3	in	in	IN
cord-011710-rz23ozxb	13	4	the	the	DT
cord-011710-rz23ozxb	13	5	current	current	JJ
cord-011710-rz23ozxb	13	6	report	report	NN
cord-011710-rz23ozxb	13	7	also	also	RB
cord-011710-rz23ozxb	13	8	complement	complement	VBP
cord-011710-rz23ozxb	13	9	observations	observation	NNS
cord-011710-rz23ozxb	13	10	from	from	IN
cord-011710-rz23ozxb	13	11	ecologic	ecologic	JJ
cord-011710-rz23ozxb	13	12	studies	study	NNS
cord-011710-rz23ozxb	13	13	[	[	-LRB-
cord-011710-rz23ozxb	13	14	5	5	CD
cord-011710-rz23ozxb	13	15	]	]	-RRB-
cord-011710-rz23ozxb	13	16	.	.	.
cord-011710-rz23ozxb	14	1	For	for	IN
cord-011710-rz23ozxb	14	2	example	example	NN
cord-011710-rz23ozxb	14	3	,	,	,
cord-011710-rz23ozxb	14	4	Japan	Japan	NNP
cord-011710-rz23ozxb	14	5	,	,	,
cord-011710-rz23ozxb	14	6	the	the	DT
cord-011710-rz23ozxb	14	7	country	country	NN
cord-011710-rz23ozxb	14	8	with	with	IN
cord-011710-rz23ozxb	14	9	highest	high	JJS
cord-011710-rz23ozxb	14	10	per	per	IN
cord-011710-rz23ozxb	14	11	capita	capita	FW
cord-011710-rz23ozxb	14	12	use	use	NN
cord-011710-rz23ozxb	14	13	of	of	IN
cord-011710-rz23ozxb	14	14	NAIs	nai	NNS
cord-011710-rz23ozxb	14	15	during	during	IN
cord-011710-rz23ozxb	14	16	the	the	DT
cord-011710-rz23ozxb	14	17	2009	2009	CD
cord-011710-rz23ozxb	14	18	pandemic	pandemic	NN
cord-011710-rz23ozxb	14	19	,	,	,
cord-011710-rz23ozxb	14	20	also	also	RB
cord-011710-rz23ozxb	14	21	had	have	VBD
cord-011710-rz23ozxb	14	22	the	the	DT
cord-011710-rz23ozxb	14	23	lowest	low	JJS
cord-011710-rz23ozxb	14	24	case	case	NN
cord-011710-rz23ozxb	14	25	-	-	HYPH
cord-011710-rz23ozxb	14	26	fatality	fatality	NN
cord-011710-rz23ozxb	14	27	rate	rate	NN
cord-011710-rz23ozxb	14	28	and	and	CC
cord-011710-rz23ozxb	14	29	remarkably	remarkably	RB
cord-011710-rz23ozxb	14	30	no	no	DT
cord-011710-rz23ozxb	14	31	reported	report	VBN
cord-011710-rz23ozxb	14	32	deaths	death	NNS
cord-011710-rz23ozxb	14	33	in	in	IN
cord-011710-rz23ozxb	14	34	A(H1N1)pdm09-infected	a(h1n1)pdm09-infected	DT
cord-011710-rz23ozxb	14	35	pregnant	pregnant	JJ
cord-011710-rz23ozxb	14	36	women	woman	NNS
cord-011710-rz23ozxb	14	37	[	[	-LRB-
cord-011710-rz23ozxb	14	38	6	6	CD
cord-011710-rz23ozxb	14	39	,	,	,
cord-011710-rz23ozxb	14	40	7	7	CD
cord-011710-rz23ozxb	14	41	]	]	-RRB-
cord-011710-rz23ozxb	14	42	.	.	.
cord-011710-rz23ozxb	15	1	More	more	RBR
cord-011710-rz23ozxb	15	2	recently	recently	RB
cord-011710-rz23ozxb	15	3	,	,	,
cord-011710-rz23ozxb	15	4	a	a	DT
cord-011710-rz23ozxb	15	5	countrybased	countrybase	VBN
cord-011710-rz23ozxb	15	6	analysis	analysis	NN
cord-011710-rz23ozxb	15	7	found	find	VBD
cord-011710-rz23ozxb	15	8	that	that	IN
cord-011710-rz23ozxb	15	9	each	each	DT
cord-011710-rz23ozxb	15	10	10	10	CD
cord-011710-rz23ozxb	15	11	%	%	NN
cord-011710-rz23ozxb	15	12	increase	increase	NN
cord-011710-rz23ozxb	15	13	in	in	IN
cord-011710-rz23ozxb	15	14	oseltamivir	oseltamivir	NN
cord-011710-rz23ozxb	15	15	supply	supply	NN
cord-011710-rz23ozxb	15	16	(	(	-LRB-
cord-011710-rz23ozxb	15	17	calculated	calculate	VBN
cord-011710-rz23ozxb	15	18	in	in	IN
cord-011710-rz23ozxb	15	19	kilograms	kilogram	NNS
cord-011710-rz23ozxb	15	20	per	per	IN
cord-011710-rz23ozxb	15	21	100	100	CD
cord-011710-rz23ozxb	15	22	000	000	CD
cord-011710-rz23ozxb	15	23	people	people	NNS
cord-011710-rz23ozxb	15	24	)	)	-RRB-
cord-011710-rz23ozxb	15	25	was	be	VBD
cord-011710-rz23ozxb	15	26	associated	associate	VBN
cord-011710-rz23ozxb	15	27	with	with	IN
cord-011710-rz23ozxb	15	28	a	a	DT
cord-011710-rz23ozxb	15	29	1.6	1.6	CD
cord-011710-rz23ozxb	15	30	%	%	NN
cord-011710-rz23ozxb	15	31	reduction	reduction	NN
cord-011710-rz23ozxb	15	32	in	in	IN
cord-011710-rz23ozxb	15	33	A	a	NN
cord-011710-rz23ozxb	15	34	(	(	-LRB-
cord-011710-rz23ozxb	15	35	H1N1)pdm09	h1n1)pdm09	CD
cord-011710-rz23ozxb	15	36	mortality	mortality	NN
cord-011710-rz23ozxb	15	37	[	[	-LRB-
cord-011710-rz23ozxb	15	38	8	8	CD
cord-011710-rz23ozxb	15	39	]	]	-RRB-
cord-011710-rz23ozxb	15	40	.	.	.
cord-011710-rz23ozxb	16	1	While	while	IN
cord-011710-rz23ozxb	16	2	previous	previous	JJ
cord-011710-rz23ozxb	16	3	analyses	analysis	NNS
cord-011710-rz23ozxb	16	4	and	and	CC
cord-011710-rz23ozxb	16	5	the	the	DT
cord-011710-rz23ozxb	16	6	current	current	JJ
cord-011710-rz23ozxb	16	7	one	one	CD
cord-011710-rz23ozxb	16	8	have	have	VBP
cord-011710-rz23ozxb	16	9	generally	generally	RB
cord-011710-rz23ozxb	16	10	found	find	VBN
cord-011710-rz23ozxb	16	11	greater	great	JJR
cord-011710-rz23ozxb	16	12	effects	effect	NNS
cord-011710-rz23ozxb	16	13	with	with	IN
cord-011710-rz23ozxb	16	14	earlier	early	RBR
cord-011710-rz23ozxb	16	15	compared	compare	VBN
cord-011710-rz23ozxb	16	16	with	with	IN
cord-011710-rz23ozxb	16	17	later	later	JJ
cord-011710-rz23ozxb	16	18	therapy	therapy	NN
cord-011710-rz23ozxb	16	19	,	,	,
cord-011710-rz23ozxb	16	20	it	-PRON-	PRP
cord-011710-rz23ozxb	16	21	is	be	VBZ
cord-011710-rz23ozxb	16	22	important	important	JJ
cord-011710-rz23ozxb	16	23	to	to	TO
cord-011710-rz23ozxb	16	24	note	note	VB
cord-011710-rz23ozxb	16	25	that	that	IN
cord-011710-rz23ozxb	16	26	multiple	multiple	JJ
cord-011710-rz23ozxb	16	27	observational	observational	JJ
cord-011710-rz23ozxb	16	28	reports	report	NNS
cord-011710-rz23ozxb	16	29	in	in	IN
cord-011710-rz23ozxb	16	30	those	those	DT
cord-011710-rz23ozxb	16	31	hospitalized	hospitalize	VBN
cord-011710-rz23ozxb	16	32	with	with	IN
cord-011710-rz23ozxb	16	33	seasonal	seasonal	JJ
cord-011710-rz23ozxb	16	34	,	,	,
cord-011710-rz23ozxb	16	35	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-011710-rz23ozxb	16	36	,	,	,
cord-011710-rz23ozxb	16	37	or	or	CC
cord-011710-rz23ozxb	16	38	avian	avian	JJ
cord-011710-rz23ozxb	16	39	A(H5N1	A(H5N1	NNP
cord-011710-rz23ozxb	16	40	)	)	-RRB-
cord-011710-rz23ozxb	17	1	influenza	influenza	NN
cord-011710-rz23ozxb	17	2	indicate	indicate	VBP
cord-011710-rz23ozxb	17	3	that	that	IN
cord-011710-rz23ozxb	17	4	a	a	DT
cord-011710-rz23ozxb	17	5	treatment	treatment	NN
cord-011710-rz23ozxb	17	6	benefit	benefit	NN
cord-011710-rz23ozxb	17	7	can	can	MD
cord-011710-rz23ozxb	17	8	be	be	VB
cord-011710-rz23ozxb	17	9	demonstrated	demonstrate	VBN
cord-011710-rz23ozxb	17	10	up	up	RP
cord-011710-rz23ozxb	17	11	to	to	TO
cord-011710-rz23ozxb	17	12	5	5	CD
cord-011710-rz23ozxb	17	13	days	day	NNS
cord-011710-rz23ozxb	17	14	after	after	IN
cord-011710-rz23ozxb	17	15	symptom	symptom	NN
cord-011710-rz23ozxb	17	16	onset	onset	NN
cord-011710-rz23ozxb	17	17	,	,	,
cord-011710-rz23ozxb	17	18	including	include	VBG
cord-011710-rz23ozxb	17	19	studies	study	NNS
cord-011710-rz23ozxb	17	20	in	in	IN
cord-011710-rz23ozxb	17	21	high	high	JJ
cord-011710-rz23ozxb	17	22	-	-	HYPH
cord-011710-rz23ozxb	17	23	risk	risk	NN
cord-011710-rz23ozxb	17	24	groups	group	NNS
cord-011710-rz23ozxb	17	25	such	such	JJ
cord-011710-rz23ozxb	17	26	as	as	IN
cord-011710-rz23ozxb	17	27	pregnant	pregnant	JJ
cord-011710-rz23ozxb	17	28	women	woman	NNS
cord-011710-rz23ozxb	17	29	[	[	-LRB-
cord-011710-rz23ozxb	17	30	2	2	CD
cord-011710-rz23ozxb	17	31	]	]	-RRB-
cord-011710-rz23ozxb	17	32	[	[	-LRB-
cord-011710-rz23ozxb	17	33	3	3	CD
cord-011710-rz23ozxb	17	34	]	]	-RRB-
cord-011710-rz23ozxb	17	35	[	[	-LRB-
cord-011710-rz23ozxb	17	36	4	4	CD
cord-011710-rz23ozxb	17	37	]	]	-RRB-
cord-011710-rz23ozxb	18	1	[	[	-LRB-
cord-011710-rz23ozxb	18	2	9	9	CD
cord-011710-rz23ozxb	18	3	]	]	-RRB-
cord-011710-rz23ozxb	18	4	[	[	-LRB-
cord-011710-rz23ozxb	18	5	10	10	CD
cord-011710-rz23ozxb	18	6	]	]	-RRB-
cord-011710-rz23ozxb	18	7	[	[	-LRB-
cord-011710-rz23ozxb	18	8	11	11	CD
cord-011710-rz23ozxb	18	9	]	]	-RRB-
cord-011710-rz23ozxb	18	10	.	.	.
cord-011710-rz23ozxb	19	1	It	-PRON-	PRP
cord-011710-rz23ozxb	19	2	makes	make	VBZ
cord-011710-rz23ozxb	19	3	sense	sense	NN
cord-011710-rz23ozxb	19	4	that	that	IN
cord-011710-rz23ozxb	19	5	even	even	RB
cord-011710-rz23ozxb	19	6	delayed	delay	VBD
cord-011710-rz23ozxb	19	7	antiviral	antiviral	JJ
cord-011710-rz23ozxb	19	8	intervention	intervention	NN
cord-011710-rz23ozxb	19	9	would	would	MD
cord-011710-rz23ozxb	19	10	benefit	benefit	VB
cord-011710-rz23ozxb	19	11	patients	patient	NNS
cord-011710-rz23ozxb	19	12	,	,	,
cord-011710-rz23ozxb	19	13	when	when	WRB
cord-011710-rz23ozxb	19	14	one	one	PRP
cord-011710-rz23ozxb	19	15	considers	consider	VBZ
cord-011710-rz23ozxb	19	16	the	the	DT
cord-011710-rz23ozxb	19	17	protracted	protracted	JJ
cord-011710-rz23ozxb	19	18	duration	duration	NN
cord-011710-rz23ozxb	19	19	of	of	IN
cord-011710-rz23ozxb	19	20	viral	viral	JJ
cord-011710-rz23ozxb	19	21	replication	replication	NN
cord-011710-rz23ozxb	19	22	in	in	IN
cord-011710-rz23ozxb	19	23	many	many	JJ
cord-011710-rz23ozxb	19	24	patients	patient	NNS
cord-011710-rz23ozxb	19	25	with	with	IN
cord-011710-rz23ozxb	19	26	serious	serious	JJ
cord-011710-rz23ozxb	19	27	influenza	influenza	NN
cord-011710-rz23ozxb	19	28	,	,	,
cord-011710-rz23ozxb	19	29	sometimes	sometimes	RB
cord-011710-rz23ozxb	19	30	despite	despite	IN
cord-011710-rz23ozxb	19	31	oseltamivir	oseltamivir	NNP
cord-011710-rz23ozxb	19	32	administration	administration	NN
cord-011710-rz23ozxb	19	33	[	[	-LRB-
cord-011710-rz23ozxb	19	34	12	12	CD
cord-011710-rz23ozxb	19	35	,	,	,
cord-011710-rz23ozxb	19	36	13	13	CD
cord-011710-rz23ozxb	19	37	]	]	-RRB-
cord-011710-rz23ozxb	19	38	,	,	,
cord-011710-rz23ozxb	19	39	compared	compare	VBN
cord-011710-rz23ozxb	19	40	with	with	IN
cord-011710-rz23ozxb	19	41	its	-PRON-	PRP$
cord-011710-rz23ozxb	19	42	relatively	relatively	RB
cord-011710-rz23ozxb	19	43	short	short	JJ
cord-011710-rz23ozxb	19	44	duration	duration	NN
cord-011710-rz23ozxb	19	45	in	in	IN
cord-011710-rz23ozxb	19	46	outpatient	outpatient	NN
cord-011710-rz23ozxb	19	47	adults	adult	NNS
cord-011710-rz23ozxb	19	48	with	with	IN
cord-011710-rz23ozxb	19	49	uncomplicated	uncomplicated	JJ
cord-011710-rz23ozxb	19	50	influenza	influenza	NN
cord-011710-rz23ozxb	19	51	.	.	.
cord-011710-rz23ozxb	20	1	As	as	IN
cord-011710-rz23ozxb	20	2	pointed	point	VBN
cord-011710-rz23ozxb	20	3	out	out	RP
cord-011710-rz23ozxb	20	4	by	by	IN
cord-011710-rz23ozxb	20	5	Muthuri	Muthuri	NNP
cord-011710-rz23ozxb	20	6	et	et	NNP
cord-011710-rz23ozxb	20	7	al	al	NNP
cord-011710-rz23ozxb	20	8	,	,	,
cord-011710-rz23ozxb	20	9	the	the	DT
cord-011710-rz23ozxb	20	10	timing	timing	NN
cord-011710-rz23ozxb	20	11	of	of	IN
cord-011710-rz23ozxb	20	12	NAI	NAI	NNP
cord-011710-rz23ozxb	20	13	initiation	initiation	NN
cord-011710-rz23ozxb	20	14	was	be	VBD
cord-011710-rz23ozxb	20	15	examined	examine	VBN
cord-011710-rz23ozxb	20	16	carefully	carefully	RB
cord-011710-rz23ozxb	20	17	in	in	IN
cord-011710-rz23ozxb	20	18	only	only	RB
cord-011710-rz23ozxb	20	19	a	a	DT
cord-011710-rz23ozxb	20	20	few	few	JJ
cord-011710-rz23ozxb	20	21	studies	study	NNS
cord-011710-rz23ozxb	20	22	.	.	.
cord-011710-rz23ozxb	21	1	Delayed	delay	VBN
cord-011710-rz23ozxb	21	2	initiation	initiation	NN
cord-011710-rz23ozxb	21	3	often	often	RB
cord-011710-rz23ozxb	21	4	reflected	reflect	VBD
cord-011710-rz23ozxb	21	5	late	late	JJ
cord-011710-rz23ozxb	21	6	diagnosis	diagnosis	NN
cord-011710-rz23ozxb	21	7	or	or	CC
cord-011710-rz23ozxb	21	8	presentation	presentation	NN
cord-011710-rz23ozxb	21	9	to	to	TO
cord-011710-rz23ozxb	21	10	care	care	VB
cord-011710-rz23ozxb	21	11	and	and	CC
cord-011710-rz23ozxb	21	12	belated	belated	JJ
cord-011710-rz23ozxb	21	13	efforts	effort	NNS
cord-011710-rz23ozxb	21	14	at	at	IN
cord-011710-rz23ozxb	21	15	salvage	salvage	NN
cord-011710-rz23ozxb	21	16	.	.	.
cord-011710-rz23ozxb	22	1	Indeed	indeed	RB
cord-011710-rz23ozxb	22	2	,	,	,
cord-011710-rz23ozxb	22	3	during	during	IN
cord-011710-rz23ozxb	22	4	the	the	DT
cord-011710-rz23ozxb	22	5	pandemic	pandemic	NN
cord-011710-rz23ozxb	22	6	,	,	,
cord-011710-rz23ozxb	22	7	misunderstanding	misunderstand	VBG
cord-011710-rz23ozxb	22	8	the	the	DT
cord-011710-rz23ozxb	22	9	potential	potential	JJ
cord-011710-rz23ozxb	22	10	value	value	NN
cord-011710-rz23ozxb	22	11	of	of	IN
cord-011710-rz23ozxb	22	12	therapy	therapy	NN
cord-011710-rz23ozxb	22	13	initiated	initiate	VBN
cord-011710-rz23ozxb	22	14	beyond	beyond	IN
cord-011710-rz23ozxb	22	15	48	48	CD
cord-011710-rz23ozxb	22	16	hours	hour	NNS
cord-011710-rz23ozxb	22	17	of	of	IN
cord-011710-rz23ozxb	22	18	illness	illness	NN
cord-011710-rz23ozxb	22	19	unfortunately	unfortunately	RB
cord-011710-rz23ozxb	22	20	led	lead	VBD
cord-011710-rz23ozxb	22	21	many	many	JJ
cord-011710-rz23ozxb	22	22	clinicians	clinician	NNS
cord-011710-rz23ozxb	22	23	to	to	TO
cord-011710-rz23ozxb	22	24	not	not	RB
cord-011710-rz23ozxb	22	25	administer	administer	VB
cord-011710-rz23ozxb	22	26	NAIs	nai	NNS
cord-011710-rz23ozxb	22	27	to	to	IN
cord-011710-rz23ozxb	22	28	those	those	DT
cord-011710-rz23ozxb	22	29	who	who	WP
cord-011710-rz23ozxb	22	30	might	may	MD
cord-011710-rz23ozxb	22	31	have	have	VB
cord-011710-rz23ozxb	22	32	benefited	benefit	VBN
cord-011710-rz23ozxb	22	33	.	.	.
cord-011710-rz23ozxb	23	1	Thus	thus	RB
cord-011710-rz23ozxb	23	2	,	,	,
cord-011710-rz23ozxb	23	3	using	use	VBG
cord-011710-rz23ozxb	23	4	48	48	CD
cord-011710-rz23ozxb	23	5	hours	hour	NNS
cord-011710-rz23ozxb	23	6	as	as	IN
cord-011710-rz23ozxb	23	7	a	a	DT
cord-011710-rz23ozxb	23	8	threshold	threshold	NN
cord-011710-rz23ozxb	23	9	for	for	IN
cord-011710-rz23ozxb	23	10	delayed	delay	VBN
cord-011710-rz23ozxb	23	11	therapy	therapy	NN
cord-011710-rz23ozxb	23	12	in	in	IN
cord-011710-rz23ozxb	23	13	hospitalized	hospitalize	VBN
cord-011710-rz23ozxb	23	14	patients	patient	NNS
cord-011710-rz23ozxb	23	15	covers	cover	VBZ
cord-011710-rz23ozxb	23	16	a	a	DT
cord-011710-rz23ozxb	23	17	diversity	diversity	NN
cord-011710-rz23ozxb	23	18	of	of	IN
cord-011710-rz23ozxb	23	19	reasons	reason	NNS
cord-011710-rz23ozxb	23	20	for	for	IN
cord-011710-rz23ozxb	23	21	late	late	JJ
cord-011710-rz23ozxb	23	22	onset	onset	NN
cord-011710-rz23ozxb	23	23	of	of	IN
cord-011710-rz23ozxb	23	24	therapy	therapy	NN
cord-011710-rz23ozxb	23	25	and	and	CC
cord-011710-rz23ozxb	23	26	may	may	MD
cord-011710-rz23ozxb	23	27	be	be	VB
cord-011710-rz23ozxb	23	28	less	less	RBR
cord-011710-rz23ozxb	23	29	relevant	relevant	JJ
cord-011710-rz23ozxb	23	30	than	than	IN
cord-011710-rz23ozxb	23	31	in	in	IN
cord-011710-rz23ozxb	23	32	outpatient	outpatient	NN
cord-011710-rz23ozxb	23	33	settings	setting	NNS
cord-011710-rz23ozxb	23	34	.	.	.
cord-011710-rz23ozxb	24	1	While	while	IN
cord-011710-rz23ozxb	24	2	time	time	NN
cord-011710-rz23ozxb	24	3	to	to	IN
cord-011710-rz23ozxb	24	4	treatment	treatment	NN
cord-011710-rz23ozxb	24	5	initiation	initiation	NN
cord-011710-rz23ozxb	24	6	is	be	VBZ
cord-011710-rz23ozxb	24	7	a	a	DT
cord-011710-rz23ozxb	24	8	key	key	JJ
cord-011710-rz23ozxb	24	9	variable	variable	NN
cord-011710-rz23ozxb	24	10	in	in	IN
cord-011710-rz23ozxb	24	11	assessing	assess	VBG
cord-011710-rz23ozxb	24	12	effectiveness	effectiveness	NN
cord-011710-rz23ozxb	24	13	,	,	,
cord-011710-rz23ozxb	24	14	future	future	JJ
cord-011710-rz23ozxb	24	15	analyses	analysis	NNS
cord-011710-rz23ozxb	24	16	should	should	MD
cord-011710-rz23ozxb	24	17	also	also	RB
cord-011710-rz23ozxb	24	18	examine	examine	VB
cord-011710-rz23ozxb	24	19	illness	illness	NN
cord-011710-rz23ozxb	24	20	severity	severity	NN
cord-011710-rz23ozxb	24	21	,	,	,
cord-011710-rz23ozxb	24	22	cause	cause	VB
cord-011710-rz23ozxb	24	23	for	for	IN
cord-011710-rz23ozxb	24	24	hospitalization	hospitalization	NN
cord-011710-rz23ozxb	24	25	(	(	-LRB-
cord-011710-rz23ozxb	24	26	eg	eg	IN
cord-011710-rz23ozxb	24	27	,	,	,
cord-011710-rz23ozxb	24	28	influenza	influenza	NN
cord-011710-rz23ozxb	24	29	-	-	HYPH
cord-011710-rz23ozxb	24	30	associated	associate	VBN
cord-011710-rz23ozxb	24	31	pneumonia	pneumonia	NN
cord-011710-rz23ozxb	24	32	,	,	,
cord-011710-rz23ozxb	24	33	exacerbations	exacerbation	NNS
cord-011710-rz23ozxb	24	34	of	of	IN
cord-011710-rz23ozxb	24	35	underlying	underlying	JJ
cord-011710-rz23ozxb	24	36	conditions	condition	NNS
cord-011710-rz23ozxb	24	37	,	,	,
cord-011710-rz23ozxb	24	38	and	and	CC
cord-011710-rz23ozxb	24	39	presence	presence	NN
cord-011710-rz23ozxb	24	40	of	of	IN
cord-011710-rz23ozxb	24	41	secondary	secondary	JJ
cord-011710-rz23ozxb	24	42	bacterial	bacterial	JJ
cord-011710-rz23ozxb	24	43	infections	infection	NNS
cord-011710-rz23ozxb	24	44	)	)	-RRB-
cord-011710-rz23ozxb	24	45	,	,	,
cord-011710-rz23ozxb	24	46	comorbidities	comorbiditie	NNS
cord-011710-rz23ozxb	24	47	,	,	,
cord-011710-rz23ozxb	24	48	and	and	CC
cord-011710-rz23ozxb	24	49	virologic	virologic	JJ
cord-011710-rz23ozxb	24	50	markers	marker	NNS
cord-011710-rz23ozxb	24	51	at	at	IN
cord-011710-rz23ozxb	24	52	the	the	DT
cord-011710-rz23ozxb	24	53	time	time	NN
cord-011710-rz23ozxb	24	54	of	of	IN
cord-011710-rz23ozxb	24	55	initiating	initiate	VBG
cord-011710-rz23ozxb	24	56	therapy	therapy	NN
cord-011710-rz23ozxb	24	57	,	,	,
cord-011710-rz23ozxb	24	58	preferably	preferably	RB
cord-011710-rz23ozxb	24	59	with	with	IN
cord-011710-rz23ozxb	24	60	propensity	propensity	NN
cord-011710-rz23ozxb	24	61	scoring	scoring	NN
cord-011710-rz23ozxb	24	62	that	that	WDT
cord-011710-rz23ozxb	24	63	takes	take	VBZ
cord-011710-rz23ozxb	24	64	such	such	JJ
cord-011710-rz23ozxb	24	65	factors	factor	NNS
cord-011710-rz23ozxb	24	66	into	into	IN
cord-011710-rz23ozxb	24	67	consideration	consideration	NN
cord-011710-rz23ozxb	24	68	.	.	.
cord-011710-rz23ozxb	25	1	This	this	DT
cord-011710-rz23ozxb	25	2	current	current	JJ
cord-011710-rz23ozxb	25	3	meta	meta	JJ
cord-011710-rz23ozxb	25	4	-	-	HYPH
cord-011710-rz23ozxb	25	5	analysis	analysis	NN
cord-011710-rz23ozxb	25	6	has	have	VBZ
cord-011710-rz23ozxb	25	7	advanced	advance	VBN
cord-011710-rz23ozxb	25	8	our	-PRON-	PRP$
cord-011710-rz23ozxb	25	9	understanding	understanding	NN
cord-011710-rz23ozxb	25	10	of	of	IN
cord-011710-rz23ozxb	25	11	the	the	DT
cord-011710-rz23ozxb	25	12	effectiveness	effectiveness	NN
cord-011710-rz23ozxb	25	13	of	of	IN
cord-011710-rz23ozxb	25	14	antiviral	antiviral	JJ
cord-011710-rz23ozxb	25	15	therapy	therapy	NN
cord-011710-rz23ozxb	25	16	for	for	IN
cord-011710-rz23ozxb	25	17	the	the	DT
cord-011710-rz23ozxb	25	18	management	management	NN
cord-011710-rz23ozxb	25	19	of	of	IN
cord-011710-rz23ozxb	25	20	pandemic	pandemic	NNP
cord-011710-rz23ozxb	25	21	influenza	influenza	NN
cord-011710-rz23ozxb	25	22	that	that	WDT
cord-011710-rz23ozxb	25	23	began	begin	VBD
cord-011710-rz23ozxb	25	24	during	during	IN
cord-011710-rz23ozxb	25	25	the	the	DT
cord-011710-rz23ozxb	25	26	1968	1968	CD
cord-011710-rz23ozxb	25	27	-	-	SYM
cord-011710-rz23ozxb	25	28	1969	1969	CD
cord-011710-rz23ozxb	25	29	global	global	JJ
cord-011710-rz23ozxb	25	30	outbreak	outbreak	NN
cord-011710-rz23ozxb	25	31	caused	cause	VBN
cord-011710-rz23ozxb	25	32	by	by	IN
cord-011710-rz23ozxb	25	33	the	the	DT
cord-011710-rz23ozxb	25	34	influenza	influenza	NN
cord-011710-rz23ozxb	25	35	A(H3N2	A(H3N2	NNP
cord-011710-rz23ozxb	25	36	)	)	-RRB-
cord-011710-rz23ozxb	26	1	Hong	Hong	NNP
cord-011710-rz23ozxb	26	2	Kong	Kong	NNP
cord-011710-rz23ozxb	26	3	virus	virus	NN
cord-011710-rz23ozxb	26	4	44	44	CD
cord-011710-rz23ozxb	26	5	years	year	NNS
cord-011710-rz23ozxb	26	6	ago	ago	RB
cord-011710-rz23ozxb	26	7	.	.	.
cord-011710-rz23ozxb	27	1	Antiviral	antiviral	JJ
cord-011710-rz23ozxb	27	2	therapy	therapy	NN
cord-011710-rz23ozxb	27	3	with	with	IN
cord-011710-rz23ozxb	27	4	amantadine	amantadine	NNP
cord-011710-rz23ozxb	27	5	was	be	VBD
cord-011710-rz23ozxb	27	6	then	then	RB
cord-011710-rz23ozxb	27	7	first	first	RB
cord-011710-rz23ozxb	27	8	demonstrated	demonstrate	VBD
cord-011710-rz23ozxb	27	9	to	to	TO
cord-011710-rz23ozxb	27	10	be	be	VB
cord-011710-rz23ozxb	27	11	more	more	RBR
cord-011710-rz23ozxb	27	12	effective	effective	JJ
cord-011710-rz23ozxb	27	13	than	than	IN
cord-011710-rz23ozxb	27	14	placebo	placebo	NN
cord-011710-rz23ozxb	27	15	in	in	IN
cord-011710-rz23ozxb	27	16	accelerating	accelerate	VBG
cord-011710-rz23ozxb	27	17	the	the	DT
cord-011710-rz23ozxb	27	18	resolution	resolution	NN
cord-011710-rz23ozxb	27	19	of	of	IN
cord-011710-rz23ozxb	27	20	pandemic	pandemic	JJ
cord-011710-rz23ozxb	27	21	illness	illness	NN
cord-011710-rz23ozxb	27	22	in	in	IN
cord-011710-rz23ozxb	27	23	otherwise	otherwise	RB
cord-011710-rz23ozxb	27	24	healthy	healthy	JJ
cord-011710-rz23ozxb	27	25	adults	adult	NNS
cord-011710-rz23ozxb	27	26	[	[	-LRB-
cord-011710-rz23ozxb	27	27	14	14	CD
cord-011710-rz23ozxb	27	28	,	,	,
cord-011710-rz23ozxb	27	29	15	15	CD
cord-011710-rz23ozxb	27	30	]	]	-RRB-
cord-011710-rz23ozxb	27	31	.	.	.
cord-011710-rz23ozxb	28	1	In	in	IN
cord-011710-rz23ozxb	28	2	1978	1978	CD
cord-011710-rz23ozxb	28	3	,	,	,
cord-011710-rz23ozxb	28	4	during	during	IN
cord-011710-rz23ozxb	28	5	the	the	DT
cord-011710-rz23ozxb	28	6	Russian	russian	JJ
cord-011710-rz23ozxb	28	7	influenza	influenza	NN
cord-011710-rz23ozxb	28	8	A	a	NN
cord-011710-rz23ozxb	28	9	/	/	SYM
cord-011710-rz23ozxb	28	10	USSR/77(H1N1	ussr/77(h1n1	NN
cord-011710-rz23ozxb	28	11	)	)	-RRB-
cord-011710-rz23ozxb	28	12	pandemic	pandemic	NN
cord-011710-rz23ozxb	28	13	,	,	,
cord-011710-rz23ozxb	28	14	comparable	comparable	JJ
cord-011710-rz23ozxb	28	15	therapeutic	therapeutic	JJ
cord-011710-rz23ozxb	28	16	effects	effect	NNS
cord-011710-rz23ozxb	28	17	of	of	IN
cord-011710-rz23ozxb	28	18	both	both	DT
cord-011710-rz23ozxb	28	19	adamantanes	adamantane	NNS
cord-011710-rz23ozxb	28	20	,	,	,
cord-011710-rz23ozxb	28	21	amantadine	amantadine	NNP
cord-011710-rz23ozxb	28	22	and	and	CC
cord-011710-rz23ozxb	28	23	rimantadine	rimantadine	NNP
cord-011710-rz23ozxb	28	24	,	,	,
cord-011710-rz23ozxb	28	25	were	be	VBD
cord-011710-rz23ozxb	28	26	again	again	RB
cord-011710-rz23ozxb	28	27	demonstrated	demonstrate	VBN
cord-011710-rz23ozxb	28	28	using	use	VBG
cord-011710-rz23ozxb	28	29	a	a	DT
cord-011710-rz23ozxb	28	30	placebo	placebo	NN
cord-011710-rz23ozxb	28	31	-	-	HYPH
cord-011710-rz23ozxb	28	32	controlled	control	VBN
cord-011710-rz23ozxb	28	33	,	,	,
cord-011710-rz23ozxb	28	34	randomized	randomized	JJ
cord-011710-rz23ozxb	28	35	trial	trial	NN
cord-011710-rz23ozxb	28	36	design	design	NN
cord-011710-rz23ozxb	28	37	[	[	-LRB-
cord-011710-rz23ozxb	28	38	16	16	CD
cord-011710-rz23ozxb	28	39	]	]	-RRB-
cord-011710-rz23ozxb	28	40	.	.	.
cord-011710-rz23ozxb	29	1	However	however	RB
cord-011710-rz23ozxb	29	2	,	,	,
cord-011710-rz23ozxb	29	3	the	the	DT
cord-011710-rz23ozxb	29	4	limited	limited	JJ
cord-011710-rz23ozxb	29	5	usefulness	usefulness	NN
cord-011710-rz23ozxb	29	6	of	of	IN
cord-011710-rz23ozxb	29	7	the	the	DT
cord-011710-rz23ozxb	29	8	adamantane	adamantane	NNP
cord-011710-rz23ozxb	29	9	class	class	NN
cord-011710-rz23ozxb	29	10	of	of	IN
cord-011710-rz23ozxb	29	11	drugs	drug	NNS
cord-011710-rz23ozxb	29	12	for	for	IN
cord-011710-rz23ozxb	29	13	widespread	widespread	JJ
cord-011710-rz23ozxb	29	14	use	use	NN
cord-011710-rz23ozxb	29	15	on	on	IN
cord-011710-rz23ozxb	29	16	a	a	DT
cord-011710-rz23ozxb	29	17	public	public	JJ
cord-011710-rz23ozxb	29	18	health	health	NN
cord-011710-rz23ozxb	29	19	scale	scale	NN
cord-011710-rz23ozxb	29	20	came	come	VBD
cord-011710-rz23ozxb	29	21	to	to	TO
cord-011710-rz23ozxb	29	22	be	be	VB
cord-011710-rz23ozxb	29	23	recognized	recognize	VBN
cord-011710-rz23ozxb	29	24	,	,	,
cord-011710-rz23ozxb	29	25	given	give	VBN
cord-011710-rz23ozxb	29	26	the	the	DT
cord-011710-rz23ozxb	29	27	rapid	rapid	JJ
cord-011710-rz23ozxb	29	28	emergence	emergence	NN
cord-011710-rz23ozxb	29	29	of	of	IN
cord-011710-rz23ozxb	29	30	resistance	resistance	NN
cord-011710-rz23ozxb	29	31	during	during	IN
cord-011710-rz23ozxb	29	32	treatment	treatment	NN
cord-011710-rz23ozxb	29	33	and	and	CC
cord-011710-rz23ozxb	29	34	,	,	,
cord-011710-rz23ozxb	29	35	in	in	IN
cord-011710-rz23ozxb	29	36	the	the	DT
cord-011710-rz23ozxb	29	37	case	case	NN
cord-011710-rz23ozxb	29	38	of	of	IN
cord-011710-rz23ozxb	29	39	amantadine	amantadine	NNP
cord-011710-rz23ozxb	29	40	,	,	,
cord-011710-rz23ozxb	29	41	a	a	DT
cord-011710-rz23ozxb	29	42	narrow	narrow	JJ
cord-011710-rz23ozxb	29	43	toxic	toxic	JJ
cord-011710-rz23ozxb	29	44	to	to	IN
cord-011710-rz23ozxb	29	45	therapeutic	therapeutic	JJ
cord-011710-rz23ozxb	29	46	ratio	ratio	NN
cord-011710-rz23ozxb	29	47	that	that	WDT
cord-011710-rz23ozxb	29	48	necessitated	necessitate	VBD
cord-011710-rz23ozxb	29	49	individualized	individualized	JJ
cord-011710-rz23ozxb	29	50	prescribing	prescribing	NN
cord-011710-rz23ozxb	29	51	on	on	IN
cord-011710-rz23ozxb	29	52	the	the	DT
cord-011710-rz23ozxb	29	53	basis	basis	NN
cord-011710-rz23ozxb	29	54	of	of	IN
cord-011710-rz23ozxb	29	55	renal	renal	JJ
cord-011710-rz23ozxb	29	56	function	function	NN
cord-011710-rz23ozxb	29	57	and	and	CC
cord-011710-rz23ozxb	29	58	weight	weight	NN
cord-011710-rz23ozxb	29	59	,	,	,
cord-011710-rz23ozxb	29	60	plus	plus	CC
cord-011710-rz23ozxb	29	61	careful	careful	JJ
cord-011710-rz23ozxb	29	62	monitoring	monitoring	NN
cord-011710-rz23ozxb	29	63	during	during	IN
cord-011710-rz23ozxb	29	64	therapy	therapy	NN
cord-011710-rz23ozxb	29	65	because	because	IN
cord-011710-rz23ozxb	29	66	of	of	IN
cord-011710-rz23ozxb	29	67	side	side	NN
cord-011710-rz23ozxb	29	68	effects	effect	NNS
cord-011710-rz23ozxb	29	69	.	.	.
cord-011710-rz23ozxb	30	1	The	the	DT
cord-011710-rz23ozxb	30	2	development	development	NN
cord-011710-rz23ozxb	30	3	of	of	IN
cord-011710-rz23ozxb	30	4	NAI	NAI	NNP
cord-011710-rz23ozxb	30	5	therapy	therapy	NN
cord-011710-rz23ozxb	30	6	provided	provide	VBD
cord-011710-rz23ozxb	30	7	clinicians	clinician	NNS
cord-011710-rz23ozxb	30	8	and	and	CC
cord-011710-rz23ozxb	30	9	public	public	JJ
cord-011710-rz23ozxb	30	10	health	health	NN
cord-011710-rz23ozxb	30	11	decision	decision	NN
cord-011710-rz23ozxb	30	12	makers	maker	NNS
cord-011710-rz23ozxb	30	13	with	with	IN
cord-011710-rz23ozxb	30	14	treatment	treatment	NN
cord-011710-rz23ozxb	30	15	options	option	NNS
cord-011710-rz23ozxb	30	16	that	that	WDT
cord-011710-rz23ozxb	30	17	were	be	VBD
cord-011710-rz23ozxb	30	18	less	less	RBR
cord-011710-rz23ozxb	30	19	limited	limit	VBN
cord-011710-rz23ozxb	30	20	by	by	IN
cord-011710-rz23ozxb	30	21	concerns	concern	NNS
cord-011710-rz23ozxb	30	22	about	about	IN
cord-011710-rz23ozxb	30	23	viral	viral	JJ
cord-011710-rz23ozxb	30	24	resistance	resistance	NN
cord-011710-rz23ozxb	30	25	,	,	,
cord-011710-rz23ozxb	30	26	or	or	CC
cord-011710-rz23ozxb	30	27	,	,	,
cord-011710-rz23ozxb	30	28	in	in	IN
cord-011710-rz23ozxb	30	29	the	the	DT
cord-011710-rz23ozxb	30	30	case	case	NN
cord-011710-rz23ozxb	30	31	of	of	IN
cord-011710-rz23ozxb	30	32	amantadine	amantadine	NNP
cord-011710-rz23ozxb	30	33	,	,	,
cord-011710-rz23ozxb	30	34	safety	safety	NN
cord-011710-rz23ozxb	30	35	.	.	.
cord-011710-rz23ozxb	31	1	Cumulated	cumulated	JJ
cord-011710-rz23ozxb	31	2	evidence	evidence	NN
cord-011710-rz23ozxb	31	3	on	on	IN
cord-011710-rz23ozxb	31	4	NAI	NAI	NNP
cord-011710-rz23ozxb	31	5	efficacy	efficacy	NN
cord-011710-rz23ozxb	31	6	and	and	CC
cord-011710-rz23ozxb	31	7	safety	safety	NN
cord-011710-rz23ozxb	31	8	for	for	IN
cord-011710-rz23ozxb	31	9	treatment	treatment	NN
cord-011710-rz23ozxb	31	10	of	of	IN
cord-011710-rz23ozxb	31	11	seasonal	seasonal	JJ
cord-011710-rz23ozxb	31	12	influenza	influenza	NN
cord-011710-rz23ozxb	31	13	and	and	CC
cord-011710-rz23ozxb	31	14	uncertainty	uncertainty	NN
cord-011710-rz23ozxb	31	15	about	about	IN
cord-011710-rz23ozxb	31	16	the	the	DT
cord-011710-rz23ozxb	31	17	potential	potential	JJ
cord-011710-rz23ozxb	31	18	severity	severity	NN
cord-011710-rz23ozxb	31	19	of	of	IN
cord-011710-rz23ozxb	31	20	disease	disease	NN
cord-011710-rz23ozxb	31	21	caused	cause	VBN
cord-011710-rz23ozxb	31	22	by	by	IN
cord-011710-rz23ozxb	31	23	a	a	DT
cord-011710-rz23ozxb	31	24	new	new	JJ
cord-011710-rz23ozxb	31	25	virus	virus	NN
cord-011710-rz23ozxb	31	26	precluded	preclude	VBD
cord-011710-rz23ozxb	31	27	the	the	DT
cord-011710-rz23ozxb	31	28	use	use	NN
cord-011710-rz23ozxb	31	29	of	of	IN
cord-011710-rz23ozxb	31	30	the	the	DT
cord-011710-rz23ozxb	31	31	placebo	placebo	NN
cord-011710-rz23ozxb	31	32	-	-	HYPH
cord-011710-rz23ozxb	31	33	controlled	control	VBN
cord-011710-rz23ozxb	31	34	,	,	,
cord-011710-rz23ozxb	31	35	randomized	randomized	JJ
cord-011710-rz23ozxb	31	36	study	study	NN
cord-011710-rz23ozxb	31	37	design	design	NN
cord-011710-rz23ozxb	31	38	to	to	TO
cord-011710-rz23ozxb	31	39	test	test	VB
cord-011710-rz23ozxb	31	40	the	the	DT
cord-011710-rz23ozxb	31	41	hypothesis	hypothesis	NN
cord-011710-rz23ozxb	31	42	that	that	WDT
cord-011710-rz23ozxb	31	43	NAI	NAI	NNP
cord-011710-rz23ozxb	31	44	therapy	therapy	NN
cord-011710-rz23ozxb	31	45	could	could	MD
cord-011710-rz23ozxb	31	46	favorably	favorably	RB
cord-011710-rz23ozxb	31	47	impact	impact	VB
cord-011710-rz23ozxb	31	48	severe	severe	JJ
cord-011710-rz23ozxb	31	49	outcomes	outcome	NNS
cord-011710-rz23ozxb	31	50	during	during	IN
cord-011710-rz23ozxb	31	51	the	the	DT
cord-011710-rz23ozxb	31	52	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-011710-rz23ozxb	31	53	pandemic	pandemic	NN
cord-011710-rz23ozxb	31	54	.	.	.
cord-011710-rz23ozxb	32	1	Therefore	therefore	RB
cord-011710-rz23ozxb	32	2	,	,	,
cord-011710-rz23ozxb	32	3	it	-PRON-	PRP
cord-011710-rz23ozxb	32	4	fell	fall	VBD
cord-011710-rz23ozxb	32	5	to	to	IN
cord-011710-rz23ozxb	32	6	analysis	analysis	NN
cord-011710-rz23ozxb	32	7	of	of	IN
cord-011710-rz23ozxb	32	8	data	datum	NNS
cord-011710-rz23ozxb	32	9	from	from	IN
cord-011710-rz23ozxb	32	10	multiple	multiple	JJ
cord-011710-rz23ozxb	32	11	observational	observational	JJ
cord-011710-rz23ozxb	32	12	studies	study	NNS
cord-011710-rz23ozxb	32	13	to	to	TO
cord-011710-rz23ozxb	32	14	estimate	estimate	VB
cord-011710-rz23ozxb	32	15	the	the	DT
cord-011710-rz23ozxb	32	16	effect	effect	NN
cord-011710-rz23ozxb	32	17	of	of	IN
cord-011710-rz23ozxb	32	18	NAI	NAI	NNP
cord-011710-rz23ozxb	32	19	therapy	therapy	NN
cord-011710-rz23ozxb	32	20	on	on	IN
cord-011710-rz23ozxb	32	21	outcomes	outcome	NNS
cord-011710-rz23ozxb	32	22	of	of	IN
cord-011710-rz23ozxb	32	23	the	the	DT
cord-011710-rz23ozxb	32	24	2009	2009	CD
cord-011710-rz23ozxb	32	25	-	-	SYM
cord-011710-rz23ozxb	32	26	2010	2010	CD
cord-011710-rz23ozxb	32	27	pandemic	pandemic	NN
cord-011710-rz23ozxb	32	28	,	,	,
cord-011710-rz23ozxb	32	29	as	as	IN
cord-011710-rz23ozxb	32	30	has	have	VBZ
cord-011710-rz23ozxb	32	31	been	be	VBN
cord-011710-rz23ozxb	32	32	done	do	VBN
cord-011710-rz23ozxb	32	33	in	in	IN
cord-011710-rz23ozxb	32	34	the	the	DT
cord-011710-rz23ozxb	32	35	current	current	JJ
cord-011710-rz23ozxb	32	36	report	report	NN
cord-011710-rz23ozxb	32	37	.	.	.
cord-011710-rz23ozxb	33	1	The	the	DT
cord-011710-rz23ozxb	33	2	limitations	limitation	NNS
cord-011710-rz23ozxb	33	3	of	of	IN
cord-011710-rz23ozxb	33	4	the	the	DT
cord-011710-rz23ozxb	33	5	data	datum	NNS
cord-011710-rz23ozxb	33	6	and	and	CC
cord-011710-rz23ozxb	33	7	the	the	DT
cord-011710-rz23ozxb	33	8	conclusions	conclusion	NNS
cord-011710-rz23ozxb	33	9	drawn	draw	VBN
cord-011710-rz23ozxb	33	10	from	from	IN
cord-011710-rz23ozxb	33	11	them	-PRON-	PRP
cord-011710-rz23ozxb	33	12	are	be	VBP
cord-011710-rz23ozxb	33	13	thoughtfully	thoughtfully	RB
cord-011710-rz23ozxb	33	14	discussed	discuss	VBN
cord-011710-rz23ozxb	33	15	by	by	IN
cord-011710-rz23ozxb	33	16	Muthuri	Muthuri	NNP
cord-011710-rz23ozxb	33	17	et	et	NNP
cord-011710-rz23ozxb	33	18	al	al	NNP
cord-011710-rz23ozxb	33	19	.	.	.
cord-011710-rz23ozxb	34	1	For	for	IN
cord-011710-rz23ozxb	34	2	example	example	NN
cord-011710-rz23ozxb	34	3	,	,	,
cord-011710-rz23ozxb	34	4	their	-PRON-	PRP$
cord-011710-rz23ozxb	34	5	findings	finding	NNS
cord-011710-rz23ozxb	34	6	of	of	IN
cord-011710-rz23ozxb	34	7	an	an	DT
cord-011710-rz23ozxb	34	8	increased	increase	VBN
cord-011710-rz23ozxb	34	9	likelihood	likelihood	NN
cord-011710-rz23ozxb	34	10	of	of	IN
cord-011710-rz23ozxb	34	11	pneumonia	pneumonia	NN
cord-011710-rz23ozxb	34	12	with	with	IN
cord-011710-rz23ozxb	34	13	NAI	NAI	NNP
cord-011710-rz23ozxb	34	14	use	use	NN
cord-011710-rz23ozxb	34	15	and	and	CC
cord-011710-rz23ozxb	34	16	that	that	IN
cord-011710-rz23ozxb	34	17	NAI	NAI	NNP
cord-011710-rz23ozxb	34	18	treatment	treatment	NN
cord-011710-rz23ozxb	34	19	versus	versus	IN
cord-011710-rz23ozxb	34	20	no	no	DT
cord-011710-rz23ozxb	34	21	preadmission	preadmission	NN
cord-011710-rz23ozxb	34	22	NAI	NAI	NNP
cord-011710-rz23ozxb	34	23	in	in	IN
cord-011710-rz23ozxb	34	24	subsequently	subsequently	RB
cord-011710-rz23ozxb	34	25	hospitalized	hospitalize	VBN
cord-011710-rz23ozxb	34	26	patients	patient	NNS
cord-011710-rz23ozxb	34	27	did	do	VBD
cord-011710-rz23ozxb	34	28	not	not	RB
cord-011710-rz23ozxb	34	29	significantly	significantly	RB
cord-011710-rz23ozxb	34	30	reduce	reduce	VB
cord-011710-rz23ozxb	34	31	mortality	mortality	NN
cord-011710-rz23ozxb	34	32	highlight	highlight	VBP
cord-011710-rz23ozxb	34	33	the	the	DT
cord-011710-rz23ozxb	34	34	key	key	JJ
cord-011710-rz23ozxb	34	35	issue	issue	NN
cord-011710-rz23ozxb	34	36	of	of	IN
cord-011710-rz23ozxb	34	37	confounding	confound	VBG
cord-011710-rz23ozxb	34	38	by	by	IN
cord-011710-rz23ozxb	34	39	indication	indication	NN
cord-011710-rz23ozxb	34	40	.	.	.
cord-011710-rz23ozxb	35	1	As	as	IN
cord-011710-rz23ozxb	35	2	pointed	point	VBN
cord-011710-rz23ozxb	35	3	out	out	RP
cord-011710-rz23ozxb	35	4	by	by	IN
cord-011710-rz23ozxb	35	5	the	the	DT
cord-011710-rz23ozxb	35	6	authors	author	NNS
cord-011710-rz23ozxb	35	7	and	and	CC
cord-011710-rz23ozxb	35	8	previously	previously	RB
cord-011710-rz23ozxb	35	9	by	by	IN
cord-011710-rz23ozxb	35	10	others	other	NNS
cord-011710-rz23ozxb	35	11	[	[	-LRB-
cord-011710-rz23ozxb	35	12	11	11	CD
cord-011710-rz23ozxb	35	13	]	]	-RRB-
cord-011710-rz23ozxb	35	14	,	,	,
cord-011710-rz23ozxb	35	15	sicker	sick	JJR
cord-011710-rz23ozxb	35	16	patients	patient	NNS
cord-011710-rz23ozxb	35	17	are	be	VBP
cord-011710-rz23ozxb	35	18	more	more	RBR
cord-011710-rz23ozxb	35	19	likely	likely	JJ
cord-011710-rz23ozxb	35	20	to	to	TO
cord-011710-rz23ozxb	35	21	receive	receive	VB
cord-011710-rz23ozxb	35	22	NAI	NAI	NNP
cord-011710-rz23ozxb	35	23	therapy	therapy	NN
cord-011710-rz23ozxb	35	24	,	,	,
cord-011710-rz23ozxb	35	25	and	and	CC
cord-011710-rz23ozxb	35	26	untreated	untreated	JJ
cord-011710-rz23ozxb	35	27	patients	patient	NNS
cord-011710-rz23ozxb	35	28	are	be	VBP
cord-011710-rz23ozxb	35	29	likely	likely	JJ
cord-011710-rz23ozxb	35	30	to	to	TO
cord-011710-rz23ozxb	35	31	have	have	VB
cord-011710-rz23ozxb	35	32	had	have	VBN
cord-011710-rz23ozxb	35	33	milder	mild	JJR
cord-011710-rz23ozxb	35	34	disease	disease	NN
cord-011710-rz23ozxb	35	35	.	.	.
cord-011710-rz23ozxb	36	1	Thus	thus	RB
cord-011710-rz23ozxb	36	2	,	,	,
cord-011710-rz23ozxb	36	3	comparisons	comparison	NNS
cord-011710-rz23ozxb	36	4	between	between	IN
cord-011710-rz23ozxb	36	5	NAI	NAI	NNP
cord-011710-rz23ozxb	36	6	-	-	HYPH
cord-011710-rz23ozxb	36	7	treated	treat	VBN
cord-011710-rz23ozxb	36	8	and	and	CC
cord-011710-rz23ozxb	36	9	untreated	untreated	JJ
cord-011710-rz23ozxb	36	10	patients	patient	NNS
cord-011710-rz23ozxb	36	11	in	in	IN
cord-011710-rz23ozxb	36	12	the	the	DT
cord-011710-rz23ozxb	36	13	context	context	NN
cord-011710-rz23ozxb	36	14	of	of	IN
cord-011710-rz23ozxb	36	15	these	these	DT
cord-011710-rz23ozxb	36	16	observational	observational	JJ
cord-011710-rz23ozxb	36	17	studies	study	NNS
cord-011710-rz23ozxb	36	18	are	be	VBP
cord-011710-rz23ozxb	36	19	fraught	fraught	JJ
cord-011710-rz23ozxb	36	20	with	with	IN
cord-011710-rz23ozxb	36	21	potential	potential	JJ
cord-011710-rz23ozxb	36	22	confounding	confound	VBG
cord-011710-rz23ozxb	36	23	and	and	CC
cord-011710-rz23ozxb	36	24	underestimate	underestimate	VB
cord-011710-rz23ozxb	36	25	beneficial	beneficial	JJ
cord-011710-rz23ozxb	36	26	drug	drug	NN
cord-011710-rz23ozxb	36	27	effects	effect	NNS
cord-011710-rz23ozxb	36	28	.	.	.
cord-011710-rz23ozxb	37	1	In	in	IN
cord-011710-rz23ozxb	37	2	addition	addition	NN
cord-011710-rz23ozxb	37	3	,	,	,
cord-011710-rz23ozxb	37	4	one	one	PRP
cord-011710-rz23ozxb	37	5	needs	need	VBZ
cord-011710-rz23ozxb	37	6	to	to	TO
cord-011710-rz23ozxb	37	7	consider	consider	VB
cord-011710-rz23ozxb	37	8	the	the	DT
cord-011710-rz23ozxb	37	9	key	key	JJ
cord-011710-rz23ozxb	37	10	questions	question	NNS
cord-011710-rz23ozxb	37	11	not	not	RB
cord-011710-rz23ozxb	37	12	addressed	address	VBN
cord-011710-rz23ozxb	37	13	in	in	IN
cord-011710-rz23ozxb	37	14	this	this	DT
cord-011710-rz23ozxb	37	15	analysis	analysis	NN
cord-011710-rz23ozxb	37	16	.	.	.
cord-011710-rz23ozxb	38	1	Because	because	IN
cord-011710-rz23ozxb	38	2	the	the	DT
cord-011710-rz23ozxb	38	3	scope	scope	NN
cord-011710-rz23ozxb	38	4	of	of	IN
cord-011710-rz23ozxb	38	5	the	the	DT
cord-011710-rz23ozxb	38	6	studies	study	NNS
cord-011710-rz23ozxb	38	7	considered	consider	VBN
cord-011710-rz23ozxb	38	8	was	be	VBD
cord-011710-rz23ozxb	38	9	limited	limit	VBN
cord-011710-rz23ozxb	38	10	to	to	IN
cord-011710-rz23ozxb	38	11	hospitalized	hospitalize	VBN
cord-011710-rz23ozxb	38	12	patients	patient	NNS
cord-011710-rz23ozxb	38	13	,	,	,
cord-011710-rz23ozxb	38	14	it	-PRON-	PRP
cord-011710-rz23ozxb	38	15	could	could	MD
cord-011710-rz23ozxb	38	16	not	not	RB
cord-011710-rz23ozxb	38	17	confirm	confirm	VB
cord-011710-rz23ozxb	38	18	earlier	early	JJR
cord-011710-rz23ozxb	38	19	reports	report	NNS
cord-011710-rz23ozxb	38	20	from	from	IN
cord-011710-rz23ozxb	38	21	studies	study	NNS
cord-011710-rz23ozxb	38	22	of	of	IN
cord-011710-rz23ozxb	38	23	antiviral	antiviral	JJ
cord-011710-rz23ozxb	38	24	therapy	therapy	NN
cord-011710-rz23ozxb	38	25	for	for	IN
cord-011710-rz23ozxb	38	26	seasonal	seasonal	JJ
cord-011710-rz23ozxb	38	27	influenza	influenza	NN
cord-011710-rz23ozxb	38	28	that	that	WDT
cord-011710-rz23ozxb	38	29	found	find	VBD
cord-011710-rz23ozxb	38	30	early	early	JJ
cord-011710-rz23ozxb	38	31	treatment	treatment	NN
cord-011710-rz23ozxb	38	32	to	to	TO
cord-011710-rz23ozxb	38	33	reduce	reduce	VB
cord-011710-rz23ozxb	38	34	the	the	DT
cord-011710-rz23ozxb	38	35	risks	risk	NNS
cord-011710-rz23ozxb	38	36	of	of	IN
cord-011710-rz23ozxb	38	37	influenza	influenza	NN
cord-011710-rz23ozxb	38	38	-	-	HYPH
cord-011710-rz23ozxb	38	39	associated	associate	VBN
cord-011710-rz23ozxb	38	40	complications	complication	NNS
cord-011710-rz23ozxb	38	41	and	and	CC
cord-011710-rz23ozxb	38	42	hospitalizations	hospitalization	NNS
cord-011710-rz23ozxb	38	43	[	[	-LRB-
cord-011710-rz23ozxb	38	44	2	2	CD
cord-011710-rz23ozxb	38	45	]	]	-RRB-
cord-011710-rz23ozxb	38	46	.	.	.
cord-011710-rz23ozxb	39	1	Other	other	JJ
cord-011710-rz23ozxb	39	2	key	key	JJ
cord-011710-rz23ozxb	39	3	medical	medical	JJ
cord-011710-rz23ozxb	39	4	and	and	CC
cord-011710-rz23ozxb	39	5	public	public	JJ
cord-011710-rz23ozxb	39	6	health	health	NN
cord-011710-rz23ozxb	39	7	outcomes	outcome	NNS
cord-011710-rz23ozxb	39	8	,	,	,
cord-011710-rz23ozxb	39	9	such	such	JJ
cord-011710-rz23ozxb	39	10	as	as	IN
cord-011710-rz23ozxb	39	11	drug	drug	NN
cord-011710-rz23ozxb	39	12	tolerability	tolerability	NN
cord-011710-rz23ozxb	39	13	,	,	,
cord-011710-rz23ozxb	39	14	antiviral	antiviral	JJ
cord-011710-rz23ozxb	39	15	resistance	resistance	NN
cord-011710-rz23ozxb	39	16	emergence	emergence	NN
cord-011710-rz23ozxb	39	17	and	and	CC
cord-011710-rz23ozxb	39	18	its	-PRON-	PRP$
cord-011710-rz23ozxb	39	19	relationship	relationship	NN
cord-011710-rz23ozxb	39	20	to	to	IN
cord-011710-rz23ozxb	39	21	effectiveness	effectiveness	NN
cord-011710-rz23ozxb	39	22	,	,	,
cord-011710-rz23ozxb	39	23	the	the	DT
cord-011710-rz23ozxb	39	24	durations	duration	NNS
cord-011710-rz23ozxb	39	25	of	of	IN
cord-011710-rz23ozxb	39	26	supplemental	supplemental	JJ
cord-011710-rz23ozxb	39	27	oxygen	oxygen	NN
cord-011710-rz23ozxb	39	28	therapy	therapy	NN
cord-011710-rz23ozxb	39	29	,	,	,
cord-011710-rz23ozxb	39	30	hospital	hospital	NN
cord-011710-rz23ozxb	39	31	care	care	NN
cord-011710-rz23ozxb	39	32	,	,	,
cord-011710-rz23ozxb	39	33	transitional	transitional	JJ
cord-011710-rz23ozxb	39	34	facility	facility	NN
cord-011710-rz23ozxb	39	35	care	care	NN
cord-011710-rz23ozxb	39	36	,	,	,
cord-011710-rz23ozxb	39	37	and	and	CC
cord-011710-rz23ozxb	39	38	time	time	NN
cord-011710-rz23ozxb	39	39	to	to	IN
cord-011710-rz23ozxb	39	40	overall	overall	JJ
cord-011710-rz23ozxb	39	41	functional	functional	JJ
cord-011710-rz23ozxb	39	42	recovery	recovery	NN
cord-011710-rz23ozxb	39	43	,	,	,
cord-011710-rz23ozxb	39	44	and	and	CC
cord-011710-rz23ozxb	39	45	the	the	DT
cord-011710-rz23ozxb	39	46	causes	cause	NNS
cord-011710-rz23ozxb	39	47	of	of	IN
cord-011710-rz23ozxb	39	48	mortality	mortality	NN
cord-011710-rz23ozxb	39	49	also	also	RB
cord-011710-rz23ozxb	39	50	remain	remain	VBP
cord-011710-rz23ozxb	39	51	to	to	TO
cord-011710-rz23ozxb	39	52	be	be	VB
cord-011710-rz23ozxb	39	53	addressed	address	VBN
cord-011710-rz23ozxb	39	54	[	[	-LRB-
cord-011710-rz23ozxb	39	55	17	17	CD
cord-011710-rz23ozxb	39	56	]	]	-RRB-
cord-011710-rz23ozxb	39	57	.	.	.
cord-011710-rz23ozxb	40	1	The	the	DT
cord-011710-rz23ozxb	40	2	current	current	JJ
cord-011710-rz23ozxb	40	3	analysis	analysis	NN
cord-011710-rz23ozxb	40	4	,	,	,
cord-011710-rz23ozxb	40	5	moreover	moreover	RB
cord-011710-rz23ozxb	40	6	,	,	,
cord-011710-rz23ozxb	40	7	did	do	VBD
cord-011710-rz23ozxb	40	8	not	not	RB
cord-011710-rz23ozxb	40	9	have	have	VB
cord-011710-rz23ozxb	40	10	sufficient	sufficient	JJ
cord-011710-rz23ozxb	40	11	numbers	number	NNS
cord-011710-rz23ozxb	40	12	to	to	TO
cord-011710-rz23ozxb	40	13	assess	assess	VB
cord-011710-rz23ozxb	40	14	the	the	DT
cord-011710-rz23ozxb	40	15	effectiveness	effectiveness	NN
cord-011710-rz23ozxb	40	16	of	of	IN
cord-011710-rz23ozxb	40	17	specific	specific	JJ
cord-011710-rz23ozxb	40	18	NAIs	nai	NNS
cord-011710-rz23ozxb	40	19	other	other	JJ
cord-011710-rz23ozxb	40	20	than	than	IN
cord-011710-rz23ozxb	40	21	oseltamivir	oseltamivir	NNP
cord-011710-rz23ozxb	40	22	,	,	,
cord-011710-rz23ozxb	40	23	so	so	RB
cord-011710-rz23ozxb	40	24	it	-PRON-	PRP
cord-011710-rz23ozxb	40	25	remains	remain	VBZ
cord-011710-rz23ozxb	40	26	unclear	unclear	JJ
cord-011710-rz23ozxb	40	27	whether	whether	IN
cord-011710-rz23ozxb	40	28	inhaled	inhale	VBN
cord-011710-rz23ozxb	40	29	drugs	drug	NNS
cord-011710-rz23ozxb	40	30	such	such	JJ
cord-011710-rz23ozxb	40	31	as	as	IN
cord-011710-rz23ozxb	40	32	zanamivir	zanamivir	NNP
cord-011710-rz23ozxb	40	33	are	be	VBP
cord-011710-rz23ozxb	40	34	as	as	RB
cord-011710-rz23ozxb	40	35	safe	safe	JJ
cord-011710-rz23ozxb	40	36	and	and	CC
cord-011710-rz23ozxb	40	37	efficacious	efficacious	JJ
cord-011710-rz23ozxb	40	38	as	as	IN
cord-011710-rz23ozxb	40	39	ingested	ingest	VBN
cord-011710-rz23ozxb	40	40	or	or	CC
cord-011710-rz23ozxb	40	41	injected	inject	VBN
cord-011710-rz23ozxb	40	42	NAIs	nai	NNS
cord-011710-rz23ozxb	40	43	in	in	IN
cord-011710-rz23ozxb	40	44	hospitalized	hospitalize	VBN
cord-011710-rz23ozxb	40	45	patients	patient	NNS
cord-011710-rz23ozxb	40	46	.	.	.
cord-011710-rz23ozxb	41	1	Of	of	IN
cord-011710-rz23ozxb	41	2	note	note	NN
cord-011710-rz23ozxb	41	3	,	,	,
cord-011710-rz23ozxb	41	4	the	the	DT
cord-011710-rz23ozxb	41	5	optimal	optimal	JJ
cord-011710-rz23ozxb	41	6	dose	dose	NN
cord-011710-rz23ozxb	41	7	,	,	,
cord-011710-rz23ozxb	41	8	duration	duration	NN
cord-011710-rz23ozxb	41	9	,	,	,
cord-011710-rz23ozxb	41	10	and	and	CC
cord-011710-rz23ozxb	41	11	even	even	RB
cord-011710-rz23ozxb	41	12	makeup	makeup	NN
cord-011710-rz23ozxb	41	13	of	of	IN
cord-011710-rz23ozxb	41	14	NAI	NAI	NNP
cord-011710-rz23ozxb	41	15	therapy	therapy	NN
cord-011710-rz23ozxb	41	16	in	in	IN
cord-011710-rz23ozxb	41	17	hospitalized	hospitalize	VBN
cord-011710-rz23ozxb	41	18	influenza	influenza	NN
cord-011710-rz23ozxb	41	19	patients	patient	NNS
cord-011710-rz23ozxb	41	20	remains	remain	VBZ
cord-011710-rz23ozxb	41	21	uncertain	uncertain	JJ
cord-011710-rz23ozxb	41	22	.	.	.
cord-011710-rz23ozxb	42	1	Available	available	JJ
cord-011710-rz23ozxb	42	2	data	datum	NNS
cord-011710-rz23ozxb	42	3	suggest	suggest	VBP
cord-011710-rz23ozxb	42	4	that	that	IN
cord-011710-rz23ozxb	42	5	more	more	RBR
cord-011710-rz23ozxb	42	6	protracted	protracted	JJ
cord-011710-rz23ozxb	42	7	administration	administration	NN
cord-011710-rz23ozxb	42	8	is	be	VBZ
cord-011710-rz23ozxb	42	9	warranted	warrant	VBN
cord-011710-rz23ozxb	42	10	in	in	IN
cord-011710-rz23ozxb	42	11	seriously	seriously	RB
cord-011710-rz23ozxb	42	12	ill	ill	JJ
cord-011710-rz23ozxb	42	13	or	or	CC
cord-011710-rz23ozxb	42	14	immunocompromised	immunocompromised	JJ
cord-011710-rz23ozxb	42	15	patients	patient	NNS
cord-011710-rz23ozxb	42	16	,	,	,
cord-011710-rz23ozxb	42	17	while	while	IN
cord-011710-rz23ozxb	42	18	other	other	JJ
cord-011710-rz23ozxb	42	19	careful	careful	JJ
cord-011710-rz23ozxb	42	20	studies	study	NNS
cord-011710-rz23ozxb	42	21	using	use	VBG
cord-011710-rz23ozxb	42	22	sequential	sequential	JJ
cord-011710-rz23ozxb	42	23	sampling	sampling	NN
cord-011710-rz23ozxb	42	24	of	of	IN
cord-011710-rz23ozxb	42	25	patients	patient	NNS
cord-011710-rz23ozxb	42	26	given	give	VBN
cord-011710-rz23ozxb	42	27	oseltamivir	oseltamivir	NNS
cord-011710-rz23ozxb	42	28	have	have	VBP
cord-011710-rz23ozxb	42	29	indicated	indicate	VBN
cord-011710-rz23ozxb	42	30	a	a	DT
cord-011710-rz23ozxb	42	31	need	need	NN
cord-011710-rz23ozxb	42	32	for	for	IN
cord-011710-rz23ozxb	42	33	more	more	RBR
cord-011710-rz23ozxb	42	34	robust	robust	JJ
cord-011710-rz23ozxb	42	35	antiviral	antiviral	JJ
cord-011710-rz23ozxb	42	36	effects	effect	NNS
cord-011710-rz23ozxb	42	37	,	,	,
cord-011710-rz23ozxb	42	38	especially	especially	RB
cord-011710-rz23ozxb	42	39	in	in	IN
cord-011710-rz23ozxb	42	40	those	those	DT
cord-011710-rz23ozxb	42	41	with	with	IN
cord-011710-rz23ozxb	42	42	severe	severe	JJ
cord-011710-rz23ozxb	42	43	pneumonic	pneumonic	JJ
cord-011710-rz23ozxb	42	44	disease	disease	NN
cord-011710-rz23ozxb	42	45	[	[	-LRB-
cord-011710-rz23ozxb	42	46	12	12	CD
cord-011710-rz23ozxb	42	47	,	,	,
cord-011710-rz23ozxb	42	48	13	13	CD
cord-011710-rz23ozxb	42	49	]	]	-RRB-
cord-011710-rz23ozxb	42	50	.	.	.
cord-011710-rz23ozxb	43	1	Such	such	JJ
cord-011710-rz23ozxb	43	2	virologic	virologic	JJ
cord-011710-rz23ozxb	43	3	findings	finding	NNS
cord-011710-rz23ozxb	43	4	and	and	CC
cord-011710-rz23ozxb	43	5	the	the	DT
cord-011710-rz23ozxb	43	6	occurrence	occurrence	NN
cord-011710-rz23ozxb	43	7	of	of	IN
cord-011710-rz23ozxb	43	8	deaths	death	NNS
cord-011710-rz23ozxb	43	9	despite	despite	IN
cord-011710-rz23ozxb	43	10	early	early	JJ
cord-011710-rz23ozxb	43	11	therapy	therapy	NN
cord-011710-rz23ozxb	44	1	[	[	-LRB-
cord-011710-rz23ozxb	44	2	18	18	CD
cord-011710-rz23ozxb	44	3	]	]	-RRB-
cord-011710-rz23ozxb	44	4	highlight	highlight	VBP
cord-011710-rz23ozxb	44	5	the	the	DT
cord-011710-rz23ozxb	44	6	importance	importance	NN
cord-011710-rz23ozxb	44	7	of	of	IN
cord-011710-rz23ozxb	44	8	developing	develop	VBG
cord-011710-rz23ozxb	44	9	more	more	RBR
cord-011710-rz23ozxb	44	10	potent	potent	JJ
cord-011710-rz23ozxb	44	11	antiviral	antiviral	JJ
cord-011710-rz23ozxb	44	12	regimens	regimen	NNS
cord-011710-rz23ozxb	44	13	for	for	IN
cord-011710-rz23ozxb	44	14	such	such	JJ
cord-011710-rz23ozxb	44	15	patients	patient	NNS
cord-011710-rz23ozxb	44	16	,	,	,
cord-011710-rz23ozxb	44	17	particularly	particularly	RB
cord-011710-rz23ozxb	44	18	antiviral	antiviral	JJ
cord-011710-rz23ozxb	44	19	combinations	combination	NNS
cord-011710-rz23ozxb	44	20	.	.	.
cord-011710-rz23ozxb	45	1	However	however	RB
cord-011710-rz23ozxb	45	2	,	,	,
cord-011710-rz23ozxb	45	3	evidence	evidence	NN
cord-011710-rz23ozxb	45	4	indicates	indicate	VBZ
cord-011710-rz23ozxb	45	5	that	that	IN
cord-011710-rz23ozxb	45	6	some	some	DT
cord-011710-rz23ozxb	45	7	NAI	NAI	NNP
cord-011710-rz23ozxb	45	8	combinations	combination	NNS
cord-011710-rz23ozxb	45	9	,	,	,
cord-011710-rz23ozxb	45	10	particularly	particularly	RB
cord-011710-rz23ozxb	45	11	oseltamivir	oseltamivir	NNP
cord-011710-rz23ozxb	45	12	plus	plus	CC
cord-011710-rz23ozxb	45	13	zanamivir	zanamivir	NNP
cord-011710-rz23ozxb	45	14	,	,	,
cord-011710-rz23ozxb	45	15	may	may	MD
cord-011710-rz23ozxb	45	16	result	result	VB
cord-011710-rz23ozxb	45	17	in	in	IN
cord-011710-rz23ozxb	45	18	antagonistic	antagonistic	JJ
cord-011710-rz23ozxb	45	19	antiviral	antiviral	JJ
cord-011710-rz23ozxb	45	20	effects	effect	NNS
cord-011710-rz23ozxb	45	21	and	and	CC
cord-011710-rz23ozxb	45	22	lesser	less	JJR
cord-011710-rz23ozxb	45	23	clinical	clinical	JJ
cord-011710-rz23ozxb	45	24	benefit	benefit	NN
cord-011710-rz23ozxb	45	25	,	,	,
cord-011710-rz23ozxb	45	26	reminding	remind	VBG
cord-011710-rz23ozxb	45	27	clinicians	clinician	NNS
cord-011710-rz23ozxb	45	28	about	about	IN
cord-011710-rz23ozxb	45	29	the	the	DT
cord-011710-rz23ozxb	45	30	need	need	NN
cord-011710-rz23ozxb	45	31	for	for	IN
cord-011710-rz23ozxb	45	32	detailed	detailed	JJ
cord-011710-rz23ozxb	45	33	preclinical	preclinical	JJ
cord-011710-rz23ozxb	45	34	studies	study	NNS
cord-011710-rz23ozxb	45	35	and	and	CC
cord-011710-rz23ozxb	45	36	special	special	JJ
cord-011710-rz23ozxb	45	37	care	care	NN
cord-011710-rz23ozxb	45	38	when	when	WRB
cord-011710-rz23ozxb	45	39	moving	move	VBG
cord-011710-rz23ozxb	45	40	on	on	RP
cord-011710-rz23ozxb	45	41	to	to	IN
cord-011710-rz23ozxb	45	42	combination	combination	NN
cord-011710-rz23ozxb	45	43	antiviral	antiviral	JJ
cord-011710-rz23ozxb	45	44	therapy	therapy	NN
cord-011710-rz23ozxb	45	45	[	[	-LRB-
cord-011710-rz23ozxb	45	46	19	19	CD
cord-011710-rz23ozxb	45	47	,	,	,
cord-011710-rz23ozxb	45	48	20	20	CD
cord-011710-rz23ozxb	45	49	]	]	-RRB-
cord-011710-rz23ozxb	45	50	.	.	.
cord-011710-rz23ozxb	46	1	Hopefully	hopefully	RB
cord-011710-rz23ozxb	46	2	,	,	,
cord-011710-rz23ozxb	46	3	new	new	JJ
cord-011710-rz23ozxb	46	4	data	datum	NNS
cord-011710-rz23ozxb	46	5	to	to	TO
cord-011710-rz23ozxb	46	6	address	address	VB
cord-011710-rz23ozxb	46	7	some	some	DT
cord-011710-rz23ozxb	46	8	of	of	IN
cord-011710-rz23ozxb	46	9	these	these	DT
cord-011710-rz23ozxb	46	10	issues	issue	NNS
cord-011710-rz23ozxb	46	11	will	will	MD
cord-011710-rz23ozxb	46	12	come	come	VB
cord-011710-rz23ozxb	46	13	from	from	IN
cord-011710-rz23ozxb	46	14	,	,	,
cord-011710-rz23ozxb	46	15	in	in	IN
cord-011710-rz23ozxb	46	16	part	part	NN
cord-011710-rz23ozxb	46	17	,	,	,
cord-011710-rz23ozxb	46	18	the	the	DT
cord-011710-rz23ozxb	46	19	ongoing	ongoing	JJ
cord-011710-rz23ozxb	46	20	randomized	randomized	JJ
cord-011710-rz23ozxb	46	21	,	,	,
cord-011710-rz23ozxb	46	22	controlled	control	VBN
cord-011710-rz23ozxb	46	23	trials	trial	NNS
cord-011710-rz23ozxb	46	24	of	of	IN
cord-011710-rz23ozxb	46	25	intravenous	intravenous	JJ
cord-011710-rz23ozxb	46	26	NAIs	nai	NNS
cord-011710-rz23ozxb	46	27	.	.	.
cord-011710-rz23ozxb	47	1	Although	although	IN
cord-011710-rz23ozxb	47	2	the	the	DT
cord-011710-rz23ozxb	47	3	current	current	JJ
cord-011710-rz23ozxb	47	4	study	study	NN
cord-011710-rz23ozxb	47	5	provides	provide	VBZ
cord-011710-rz23ozxb	47	6	clinicians	clinician	NNS
cord-011710-rz23ozxb	47	7	and	and	CC
cord-011710-rz23ozxb	47	8	public	public	JJ
cord-011710-rz23ozxb	47	9	health	health	NN
cord-011710-rz23ozxb	47	10	decision	decision	NN
cord-011710-rz23ozxb	47	11	makers	maker	NNS
cord-011710-rz23ozxb	47	12	an	an	DT
cord-011710-rz23ozxb	47	13	answer	answer	NN
cord-011710-rz23ozxb	47	14	to	to	IN
cord-011710-rz23ozxb	47	15	an	an	DT
cord-011710-rz23ozxb	47	16	important	important	JJ
cord-011710-rz23ozxb	47	17	question	question	NN
cord-011710-rz23ozxb	47	18	at	at	IN
cord-011710-rz23ozxb	47	19	the	the	DT
cord-011710-rz23ozxb	47	20	apex	apex	NN
cord-011710-rz23ozxb	47	21	of	of	IN
cord-011710-rz23ozxb	47	22	the	the	DT
cord-011710-rz23ozxb	47	23	hierarchy	hierarchy	NN
cord-011710-rz23ozxb	47	24	of	of	IN
cord-011710-rz23ozxb	47	25	the	the	DT
cord-011710-rz23ozxb	47	26	therapeutic	therapeutic	JJ
cord-011710-rz23ozxb	47	27	effects	effect	NNS
cord-011710-rz23ozxb	47	28	of	of	IN
cord-011710-rz23ozxb	47	29	anti	anti	JJ
cord-011710-rz23ozxb	47	30	-	-	JJ
cord-011710-rz23ozxb	47	31	influenza	influenza	JJ
cord-011710-rz23ozxb	47	32	drug	drug	NN
cord-011710-rz23ozxb	47	33	therapy	therapy	NN
cord-011710-rz23ozxb	47	34	,	,	,
cord-011710-rz23ozxb	47	35	questions	question	NNS
cord-011710-rz23ozxb	47	36	remain	remain	VBP
cord-011710-rz23ozxb	47	37	whose	whose	WP$
cord-011710-rz23ozxb	47	38	solution	solution	NN
cord-011710-rz23ozxb	47	39	would	would	MD
cord-011710-rz23ozxb	47	40	further	far	RBR
cord-011710-rz23ozxb	47	41	advance	advance	VB
cord-011710-rz23ozxb	47	42	our	-PRON-	PRP$
cord-011710-rz23ozxb	47	43	ability	ability	NN
cord-011710-rz23ozxb	47	44	to	to	TO
cord-011710-rz23ozxb	47	45	strategically	strategically	RB
cord-011710-rz23ozxb	47	46	use	use	VB
cord-011710-rz23ozxb	47	47	antiviral	antiviral	JJ
cord-011710-rz23ozxb	47	48	drugs	drug	NNS
cord-011710-rz23ozxb	47	49	to	to	TO
cord-011710-rz23ozxb	47	50	improve	improve	VB
cord-011710-rz23ozxb	47	51	the	the	DT
cord-011710-rz23ozxb	47	52	management	management	NN
cord-011710-rz23ozxb	47	53	of	of	IN
cord-011710-rz23ozxb	47	54	influenza	influenza	NN
cord-011710-rz23ozxb	47	55	outbreaks	outbreak	NNS
cord-011710-rz23ozxb	47	56	,	,	,
cord-011710-rz23ozxb	47	57	small	small	JJ
cord-011710-rz23ozxb	47	58	and	and	CC
cord-011710-rz23ozxb	47	59	large	large	JJ
cord-011710-rz23ozxb	47	60	.	.	.
cord-011710-rz23ozxb	48	1	Some	some	DT
cord-011710-rz23ozxb	48	2	of	of	IN
cord-011710-rz23ozxb	48	3	these	these	DT
cord-011710-rz23ozxb	48	4	remaining	remain	VBG
cord-011710-rz23ozxb	48	5	questions	question	NNS
cord-011710-rz23ozxb	48	6	include	include	VBP
cord-011710-rz23ozxb	48	7	whether	whether	IN
cord-011710-rz23ozxb	48	8	antiviral	antiviral	JJ
cord-011710-rz23ozxb	48	9	therapy	therapy	NN
cord-011710-rz23ozxb	48	10	reduces	reduce	VBZ
cord-011710-rz23ozxb	48	11	transmission	transmission	NN
cord-011710-rz23ozxb	48	12	of	of	IN
cord-011710-rz23ozxb	48	13	influenza	influenza	NN
cord-011710-rz23ozxb	48	14	;	;	:
cord-011710-rz23ozxb	48	15	whether	whether	IN
cord-011710-rz23ozxb	48	16	therapy	therapy	NN
cord-011710-rz23ozxb	48	17	mitigates	mitigate	VBZ
cord-011710-rz23ozxb	48	18	disease	disease	NN
cord-011710-rz23ozxb	48	19	without	without	IN
cord-011710-rz23ozxb	48	20	reducing	reduce	VBG
cord-011710-rz23ozxb	48	21	the	the	DT
cord-011710-rz23ozxb	48	22	immune	immune	JJ
cord-011710-rz23ozxb	48	23	responses	response	NNS
cord-011710-rz23ozxb	48	24	to	to	IN
cord-011710-rz23ozxb	48	25	infection	infection	NN
cord-011710-rz23ozxb	48	26	and	and	CC
cord-011710-rz23ozxb	48	27	,	,	,
cord-011710-rz23ozxb	48	28	hence	hence	RB
cord-011710-rz23ozxb	48	29	,	,	,
cord-011710-rz23ozxb	48	30	future	future	JJ
cord-011710-rz23ozxb	48	31	protection	protection	NN
cord-011710-rz23ozxb	48	32	against	against	IN
cord-011710-rz23ozxb	48	33	drift	drift	NN
cord-011710-rz23ozxb	48	34	virus	virus	NN
cord-011710-rz23ozxb	48	35	variants	variant	NNS
cord-011710-rz23ozxb	48	36	;	;	:
cord-011710-rz23ozxb	48	37	whether	whether	IN
cord-011710-rz23ozxb	48	38	postexposure	postexposure	NN
cord-011710-rz23ozxb	48	39	prophylaxis	prophylaxis	NN
cord-011710-rz23ozxb	48	40	has	have	VBZ
cord-011710-rz23ozxb	48	41	advantages	advantage	NNS
cord-011710-rz23ozxb	48	42	over	over	IN
cord-011710-rz23ozxb	48	43	early	early	JJ
cord-011710-rz23ozxb	48	44	initiation	initiation	NN
cord-011710-rz23ozxb	48	45	of	of	IN
cord-011710-rz23ozxb	48	46	therapy	therapy	NN
cord-011710-rz23ozxb	48	47	;	;	:
cord-011710-rz23ozxb	48	48	and	and	CC
cord-011710-rz23ozxb	48	49	which	which	WDT
cord-011710-rz23ozxb	48	50	strategies	strategy	NNS
cord-011710-rz23ozxb	48	51	are	be	VBP
cord-011710-rz23ozxb	48	52	most	most	RBS
cord-011710-rz23ozxb	48	53	effective	effective	JJ
cord-011710-rz23ozxb	48	54	at	at	IN
cord-011710-rz23ozxb	48	55	reducing	reduce	VBG
cord-011710-rz23ozxb	48	56	risk	risk	NN
cord-011710-rz23ozxb	48	57	of	of	IN
cord-011710-rz23ozxb	48	58	antiviral	antiviral	JJ
cord-011710-rz23ozxb	48	59	resistance	resistance	NN
cord-011710-rz23ozxb	48	60	development	development	NN
cord-011710-rz23ozxb	48	61	and	and	CC
cord-011710-rz23ozxb	48	62	transmission	transmission	NN
cord-011710-rz23ozxb	48	63	.	.	.
cord-011710-rz23ozxb	49	1	The	the	DT
cord-011710-rz23ozxb	49	2	current	current	JJ
cord-011710-rz23ozxb	49	3	report	report	NN
cord-011710-rz23ozxb	49	4	included	include	VBD
cord-011710-rz23ozxb	49	5	studies	study	NNS
cord-011710-rz23ozxb	49	6	conducted	conduct	VBN
cord-011710-rz23ozxb	49	7	up	up	RP
cord-011710-rz23ozxb	49	8	to	to	IN
cord-011710-rz23ozxb	49	9	the	the	DT
cord-011710-rz23ozxb	49	10	declaration	declaration	NN
cord-011710-rz23ozxb	49	11	of	of	IN
cord-011710-rz23ozxb	49	12	the	the	DT
cord-011710-rz23ozxb	49	13	end	end	NN
cord-011710-rz23ozxb	49	14	of	of	IN
cord-011710-rz23ozxb	49	15	pandemic	pandemic	NN
cord-011710-rz23ozxb	49	16	,	,	,
cord-011710-rz23ozxb	49	17	in	in	IN
cord-011710-rz23ozxb	49	18	August	August	NNP
cord-011710-rz23ozxb	49	19	2010	2010	CD
cord-011710-rz23ozxb	49	20	.	.	.
cord-011710-rz23ozxb	50	1	However	however	RB
cord-011710-rz23ozxb	50	2	,	,	,
cord-011710-rz23ozxb	50	3	it	-PRON-	PRP
cord-011710-rz23ozxb	50	4	is	be	VBZ
cord-011710-rz23ozxb	50	5	important	important	JJ
cord-011710-rz23ozxb	50	6	to	to	TO
cord-011710-rz23ozxb	50	7	emphasize	emphasize	VB
cord-011710-rz23ozxb	50	8	that	that	IN
cord-011710-rz23ozxb	50	9	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-011710-rz23ozxb	50	10	continues	continue	VBZ
cord-011710-rz23ozxb	50	11	to	to	TO
cord-011710-rz23ozxb	50	12	circulate	circulate	VB
cord-011710-rz23ozxb	50	13	and	and	CC
cord-011710-rz23ozxb	50	14	cause	cause	VB
cord-011710-rz23ozxb	50	15	serious	serious	JJ
cord-011710-rz23ozxb	50	16	illness	illness	NN
cord-011710-rz23ozxb	50	17	and	and	CC
cord-011710-rz23ozxb	50	18	mortality	mortality	NN
cord-011710-rz23ozxb	50	19	.	.	.
cord-011710-rz23ozxb	51	1	Studies	study	NNS
cord-011710-rz23ozxb	51	2	of	of	IN
cord-011710-rz23ozxb	51	3	mortality	mortality	NN
cord-011710-rz23ozxb	51	4	patterns	pattern	NNS
cord-011710-rz23ozxb	51	5	in	in	IN
cord-011710-rz23ozxb	51	6	past	past	JJ
cord-011710-rz23ozxb	51	7	pandemic	pandemic	NN
cord-011710-rz23ozxb	51	8	periods	period	NNS
cord-011710-rz23ozxb	51	9	found	find	VBN
cord-011710-rz23ozxb	51	10	that	that	IN
cord-011710-rz23ozxb	51	11	individuals	individual	NNS
cord-011710-rz23ozxb	51	12	aged	age	VBN
cord-011710-rz23ozxb	51	13	≤65	≤65	CD
cord-011710-rz23ozxb	51	14	years	year	NNS
cord-011710-rz23ozxb	51	15	continued	continue	VBD
cord-011710-rz23ozxb	51	16	to	to	TO
cord-011710-rz23ozxb	51	17	experience	experience	VB
cord-011710-rz23ozxb	51	18	excess	excess	JJ
cord-011710-rz23ozxb	51	19	mortality	mortality	NN
cord-011710-rz23ozxb	51	20	for	for	IN
cord-011710-rz23ozxb	51	21	many	many	JJ
cord-011710-rz23ozxb	51	22	years	year	NNS
cord-011710-rz23ozxb	51	23	after	after	IN
cord-011710-rz23ozxb	51	24	introduction	introduction	NN
cord-011710-rz23ozxb	51	25	of	of	IN
cord-011710-rz23ozxb	51	26	the	the	DT
cord-011710-rz23ozxb	51	27	pandemic	pandemic	NN
cord-011710-rz23ozxb	51	28	strain	strain	NN
cord-011710-rz23ozxb	51	29	[	[	-LRB-
cord-011710-rz23ozxb	51	30	21	21	CD
cord-011710-rz23ozxb	51	31	]	]	-RRB-
cord-011710-rz23ozxb	51	32	.	.	.
cord-011710-rz23ozxb	52	1	Consequently	consequently	RB
cord-011710-rz23ozxb	52	2	,	,	,
cord-011710-rz23ozxb	52	3	wider	wide	JJR
cord-011710-rz23ozxb	52	4	use	use	NN
cord-011710-rz23ozxb	52	5	of	of	IN
cord-011710-rz23ozxb	52	6	NAI	NAI	NNP
cord-011710-rz23ozxb	52	7	therapy	therapy	NN
cord-011710-rz23ozxb	52	8	based	base	VBN
cord-011710-rz23ozxb	52	9	on	on	IN
cord-011710-rz23ozxb	52	10	the	the	DT
cord-011710-rz23ozxb	52	11	recommendations	recommendation	NNS
cord-011710-rz23ozxb	52	12	of	of	IN
cord-011710-rz23ozxb	52	13	Centers	Centers	NNPS
cord-011710-rz23ozxb	52	14	for	for	IN
cord-011710-rz23ozxb	52	15	Disease	Disease	NNP
cord-011710-rz23ozxb	52	16	Control	Control	NNP
cord-011710-rz23ozxb	52	17	and	and	CC
cord-011710-rz23ozxb	52	18	Prevention	Prevention	NNP
cord-011710-rz23ozxb	52	19	and	and	CC
cord-011710-rz23ozxb	52	20	the	the	DT
cord-011710-rz23ozxb	52	21	World	World	NNP
cord-011710-rz23ozxb	52	22	Health	Health	NNP
cord-011710-rz23ozxb	52	23	Organization	Organization	NNP
cord-011710-rz23ozxb	52	24	can	can	MD
cord-011710-rz23ozxb	52	25	mitigate	mitigate	VB
cord-011710-rz23ozxb	52	26	these	these	DT
cord-011710-rz23ozxb	52	27	effects	effect	NNS
cord-011710-rz23ozxb	52	28	.	.	.
cord-011710-rz23ozxb	53	1	Of	of	IN
cord-011710-rz23ozxb	53	2	concern	concern	NN
cord-011710-rz23ozxb	53	3	,	,	,
cord-011710-rz23ozxb	53	4	studies	study	NNS
cord-011710-rz23ozxb	53	5	have	have	VBP
cord-011710-rz23ozxb	53	6	found	find	VBN
cord-011710-rz23ozxb	53	7	reversion	reversion	NN
cord-011710-rz23ozxb	53	8	toward	toward	IN
cord-011710-rz23ozxb	53	9	prepandemic	prepandemic	JJ
cord-011710-rz23ozxb	53	10	prescribing	prescribe	VBG
cord-011710-rz23ozxb	53	11	patterns	pattern	NNS
cord-011710-rz23ozxb	53	12	in	in	IN
cord-011710-rz23ozxb	53	13	United	United	NNP
cord-011710-rz23ozxb	53	14	States	States	NNP
cord-011710-rz23ozxb	53	15	[	[	-LRB-
cord-011710-rz23ozxb	53	16	22	22	CD
cord-011710-rz23ozxb	53	17	]	]	-RRB-
cord-011710-rz23ozxb	53	18	and	and	CC
cord-011710-rz23ozxb	53	19	elsewhere	elsewhere	RB
cord-011710-rz23ozxb	53	20	,	,	,
cord-011710-rz23ozxb	53	21	with	with	IN
cord-011710-rz23ozxb	53	22	the	the	DT
cord-011710-rz23ozxb	53	23	consequence	consequence	NN
cord-011710-rz23ozxb	53	24	of	of	IN
cord-011710-rz23ozxb	53	25	worsened	worsened	JJ
cord-011710-rz23ozxb	53	26	outcomes	outcome	NNS
cord-011710-rz23ozxb	53	27	.	.	.
cord-011710-rz23ozxb	54	1	In	in	IN
cord-011710-rz23ozxb	54	2	closing	closing	NN
cord-011710-rz23ozxb	54	3	,	,	,
cord-011710-rz23ozxb	54	4	the	the	DT
cord-011710-rz23ozxb	54	5	current	current	JJ
cord-011710-rz23ozxb	54	6	report	report	NN
cord-011710-rz23ozxb	54	7	included	include	VBD
cord-011710-rz23ozxb	54	8	patients	patient	NNS
cord-011710-rz23ozxb	54	9	treated	treat	VBN
cord-011710-rz23ozxb	54	10	in	in	IN
cord-011710-rz23ozxb	54	11	29	29	CD
cord-011710-rz23ozxb	54	12	different	different	JJ
cord-011710-rz23ozxb	54	13	countries	country	NNS
cord-011710-rz23ozxb	54	14	,	,	,
cord-011710-rz23ozxb	54	15	reflecting	reflect	VBG
cord-011710-rz23ozxb	54	16	the	the	DT
cord-011710-rz23ozxb	54	17	global	global	JJ
cord-011710-rz23ozxb	54	18	scale	scale	NN
cord-011710-rz23ozxb	54	19	of	of	IN
cord-011710-rz23ozxb	54	20	the	the	DT
cord-011710-rz23ozxb	54	21	pandemic	pandemic	NN
cord-011710-rz23ozxb	54	22	and	and	CC
cord-011710-rz23ozxb	54	23	the	the	DT
cord-011710-rz23ozxb	54	24	widespread	widespread	JJ
cord-011710-rz23ozxb	54	25	interest	interest	NN
cord-011710-rz23ozxb	54	26	of	of	IN
cord-011710-rz23ozxb	54	27	researchers	researcher	NNS
cord-011710-rz23ozxb	54	28	in	in	IN
cord-011710-rz23ozxb	54	29	the	the	DT
cord-011710-rz23ozxb	54	30	question	question	NN
cord-011710-rz23ozxb	54	31	of	of	IN
cord-011710-rz23ozxb	54	32	the	the	DT
cord-011710-rz23ozxb	54	33	beneficial	beneficial	JJ
cord-011710-rz23ozxb	54	34	effects	effect	NNS
cord-011710-rz23ozxb	54	35	of	of	IN
cord-011710-rz23ozxb	54	36	NAI	NAI	NNP
cord-011710-rz23ozxb	54	37	therapy	therapy	NN
cord-011710-rz23ozxb	54	38	on	on	IN
cord-011710-rz23ozxb	54	39	patient	patient	JJ
cord-011710-rz23ozxb	54	40	outcomes	outcome	NNS
cord-011710-rz23ozxb	54	41	.	.	.
cord-011710-rz23ozxb	55	1	However	however	RB
cord-011710-rz23ozxb	55	2	,	,	,
cord-011710-rz23ozxb	55	3	all	all	PDT
cord-011710-rz23ozxb	55	4	the	the	DT
cord-011710-rz23ozxb	55	5	studies	study	NNS
cord-011710-rz23ozxb	55	6	included	include	VBN
cord-011710-rz23ozxb	55	7	in	in	IN
cord-011710-rz23ozxb	55	8	the	the	DT
cord-011710-rz23ozxb	55	9	systematic	systematic	JJ
cord-011710-rz23ozxb	55	10	review	review	NN
cord-011710-rz23ozxb	55	11	were	be	VBD
cord-011710-rz23ozxb	55	12	observational	observational	JJ
cord-011710-rz23ozxb	55	13	designs	design	NNS
cord-011710-rz23ozxb	55	14	,	,	,
cord-011710-rz23ozxb	55	15	most	most	JJS
cord-011710-rz23ozxb	55	16	were	be	VBD
cord-011710-rz23ozxb	55	17	retrospective	retrospective	JJ
cord-011710-rz23ozxb	55	18	,	,	,
cord-011710-rz23ozxb	55	19	and	and	CC
cord-011710-rz23ozxb	55	20	the	the	DT
cord-011710-rz23ozxb	55	21	methods	method	NNS
cord-011710-rz23ozxb	55	22	used	use	VBN
cord-011710-rz23ozxb	55	23	for	for	IN
cord-011710-rz23ozxb	55	24	data	datum	NNS
cord-011710-rz23ozxb	55	25	collection	collection	NN
cord-011710-rz23ozxb	55	26	and	and	CC
cord-011710-rz23ozxb	55	27	reporting	reporting	NN
cord-011710-rz23ozxb	55	28	varied	varied	JJ
cord-011710-rz23ozxb	55	29	,	,	,
cord-011710-rz23ozxb	55	30	so	so	CC
cord-011710-rz23ozxb	55	31	it	-PRON-	PRP
cord-011710-rz23ozxb	55	32	is	be	VBZ
cord-011710-rz23ozxb	55	33	unsurprising	unsurprising	JJ
cord-011710-rz23ozxb	55	34	that	that	IN
cord-011710-rz23ozxb	55	35	the	the	DT
cord-011710-rz23ozxb	55	36	meta	meta	NNP
cord-011710-rz23ozxb	55	37	-	-	HYPH
cord-011710-rz23ozxb	55	38	analysis	analysis	NN
cord-011710-rz23ozxb	55	39	found	find	VBD
cord-011710-rz23ozxb	55	40	considerable	considerable	JJ
cord-011710-rz23ozxb	55	41	heterogeneity	heterogeneity	NN
cord-011710-rz23ozxb	55	42	across	across	IN
cord-011710-rz23ozxb	55	43	studies	study	NNS
cord-011710-rz23ozxb	55	44	and	and	CC
cord-011710-rz23ozxb	55	45	risk	risk	NN
cord-011710-rz23ozxb	55	46	of	of	IN
cord-011710-rz23ozxb	55	47	bias	bias	NN
cord-011710-rz23ozxb	55	48	in	in	IN
cord-011710-rz23ozxb	55	49	reporting	report	VBG
cord-011710-rz23ozxb	55	50	findings	finding	NNS
cord-011710-rz23ozxb	55	51	.	.	.
cord-011710-rz23ozxb	56	1	Furthermore	furthermore	RB
cord-011710-rz23ozxb	56	2	,	,	,
cord-011710-rz23ozxb	56	3	the	the	DT
cord-011710-rz23ozxb	56	4	authors	author	NNS
cord-011710-rz23ozxb	56	5	were	be	VBD
cord-011710-rz23ozxb	56	6	hampered	hamper	VBN
cord-011710-rz23ozxb	56	7	by	by	IN
cord-011710-rz23ozxb	56	8	the	the	DT
cord-011710-rz23ozxb	56	9	lack	lack	NN
cord-011710-rz23ozxb	56	10	of	of	IN
cord-011710-rz23ozxb	56	11	access	access	NN
cord-011710-rz23ozxb	56	12	to	to	IN
cord-011710-rz23ozxb	56	13	individual	individual	JJ
cord-011710-rz23ozxb	56	14	patient	patient	NN
cord-011710-rz23ozxb	56	15	data	datum	NNS
cord-011710-rz23ozxb	56	16	.	.	.
cord-011710-rz23ozxb	57	1	Such	such	JJ
cord-011710-rz23ozxb	57	2	circumstances	circumstance	NNS
cord-011710-rz23ozxb	57	3	highlight	highlight	VBP
cord-011710-rz23ozxb	57	4	the	the	DT
cord-011710-rz23ozxb	57	5	critical	critical	JJ
cord-011710-rz23ozxb	57	6	need	need	NN
cord-011710-rz23ozxb	57	7	for	for	IN
cord-011710-rz23ozxb	57	8	clinical	clinical	JJ
cord-011710-rz23ozxb	57	9	research	research	NN
cord-011710-rz23ozxb	57	10	networks	network	NNS
cord-011710-rz23ozxb	57	11	,	,	,
cord-011710-rz23ozxb	57	12	both	both	CC
cord-011710-rz23ozxb	57	13	domestic	domestic	JJ
cord-011710-rz23ozxb	57	14	and	and	CC
cord-011710-rz23ozxb	57	15	international	international	JJ
cord-011710-rz23ozxb	57	16	,	,	,
cord-011710-rz23ozxb	57	17	that	that	WDT
cord-011710-rz23ozxb	57	18	can	can	MD
cord-011710-rz23ozxb	57	19	collect	collect	VB
cord-011710-rz23ozxb	57	20	samples	sample	NNS
cord-011710-rz23ozxb	57	21	and	and	CC
cord-011710-rz23ozxb	57	22	data	datum	NNS
cord-011710-rz23ozxb	57	23	in	in	IN
cord-011710-rz23ozxb	57	24	a	a	DT
cord-011710-rz23ozxb	57	25	systematic	systematic	JJ
cord-011710-rz23ozxb	57	26	,	,	,
cord-011710-rz23ozxb	57	27	prospective	prospective	JJ
cord-011710-rz23ozxb	57	28	manner	manner	NN
cord-011710-rz23ozxb	57	29	and	and	CC
cord-011710-rz23ozxb	57	30	conduct	conduct	VB
cord-011710-rz23ozxb	57	31	randomized	randomized	JJ
cord-011710-rz23ozxb	57	32	trials	trial	NNS
cord-011710-rz23ozxb	57	33	of	of	IN
cord-011710-rz23ozxb	57	34	interventions	intervention	NNS
cord-011710-rz23ozxb	57	35	.	.	.
cord-011710-rz23ozxb	58	1	In	in	IN
cord-011710-rz23ozxb	58	2	this	this	DT
cord-011710-rz23ozxb	58	3	regard	regard	NN
cord-011710-rz23ozxb	58	4	,	,	,
cord-011710-rz23ozxb	58	5	a	a	DT
cord-011710-rz23ozxb	58	6	number	number	NN
cord-011710-rz23ozxb	58	7	of	of	IN
cord-011710-rz23ozxb	58	8	international	international	JJ
cord-011710-rz23ozxb	58	9	funding	funding	NN
cord-011710-rz23ozxb	58	10	organizations	organization	NNS
cord-011710-rz23ozxb	58	11	recently	recently	RB
cord-011710-rz23ozxb	58	12	have	have	VBP
cord-011710-rz23ozxb	58	13	supported	support	VBN
cord-011710-rz23ozxb	58	14	the	the	DT
cord-011710-rz23ozxb	58	15	formation	formation	NN
cord-011710-rz23ozxb	58	16	of	of	IN
cord-011710-rz23ozxb	58	17	the	the	DT
cord-011710-rz23ozxb	58	18	International	International	NNP
cord-011710-rz23ozxb	58	19	Severe	Severe	NNP
cord-011710-rz23ozxb	58	20	Acute	Acute	NNP
cord-011710-rz23ozxb	58	21	Respiratory	Respiratory	NNP
cord-011710-rz23ozxb	58	22	and	and	CC
cord-011710-rz23ozxb	58	23	Emerging	Emerging	NNP
cord-011710-rz23ozxb	58	24	Infection	Infection	NNP
cord-011710-rz23ozxb	58	25	Consortium	Consortium	NNP
cord-011710-rz23ozxb	58	26	(	(	-LRB-
cord-011710-rz23ozxb	58	27	ISARIC	ISARIC	NNP
cord-011710-rz23ozxb	58	28	)	)	-RRB-
cord-011710-rz23ozxb	58	29	,	,	,
cord-011710-rz23ozxb	58	30	a	a	DT
cord-011710-rz23ozxb	58	31	global	global	JJ
cord-011710-rz23ozxb	58	32	federation	federation	NN
cord-011710-rz23ozxb	58	33	of	of	IN
cord-011710-rz23ozxb	58	34	>	>	SYM
cord-011710-rz23ozxb	58	35	30	30	CD
cord-011710-rz23ozxb	58	36	existing	exist	VBG
cord-011710-rz23ozxb	58	37	clinical	clinical	JJ
cord-011710-rz23ozxb	58	38	research	research	NN
cord-011710-rz23ozxb	58	39	networks	network	NNS
cord-011710-rz23ozxb	58	40	,	,	,
cord-011710-rz23ozxb	58	41	launched	launch	VBN
cord-011710-rz23ozxb	58	42	in	in	IN
cord-011710-rz23ozxb	58	43	December	December	NNP
cord-011710-rz23ozxb	58	44	2012	2012	CD
cord-011710-rz23ozxb	58	45	[	[	-LRB-
cord-011710-rz23ozxb	58	46	23	23	CD
cord-011710-rz23ozxb	58	47	]	]	-RRB-
cord-011710-rz23ozxb	58	48	.	.	.
cord-011710-rz23ozxb	59	1	ISARIC	ISARIC	NNP
cord-011710-rz23ozxb	59	2	is	be	VBZ
cord-011710-rz23ozxb	59	3	committed	commit	VBN
cord-011710-rz23ozxb	59	4	to	to	IN
cord-011710-rz23ozxb	59	5	undertaking	undertaking	JJ
cord-011710-rz23ozxb	59	6	pathogenesis	pathogenesis	NN
cord-011710-rz23ozxb	59	7	and	and	CC
cord-011710-rz23ozxb	59	8	treatment	treatment	NN
cord-011710-rz23ozxb	59	9	studies	study	NNS
cord-011710-rz23ozxb	59	10	both	both	DT
cord-011710-rz23ozxb	59	11	in	in	IN
cord-011710-rz23ozxb	59	12	response	response	NN
cord-011710-rz23ozxb	59	13	to	to	IN
cord-011710-rz23ozxb	59	14	emerging	emerge	VBG
cord-011710-rz23ozxb	59	15	infectious	infectious	JJ
cord-011710-rz23ozxb	59	16	disease	disease	NN
cord-011710-rz23ozxb	59	17	events	event	NNS
cord-011710-rz23ozxb	59	18	and	and	CC
cord-011710-rz23ozxb	59	19	in	in	IN
cord-011710-rz23ozxb	59	20	severe	severe	JJ
cord-011710-rz23ozxb	59	21	acute	acute	JJ
cord-011710-rz23ozxb	59	22	respiratory	respiratory	JJ
cord-011710-rz23ozxb	59	23	infections	infection	NNS
cord-011710-rz23ozxb	59	24	necessitating	necessitate	VBG
cord-011710-rz23ozxb	59	25	hospitalization	hospitalization	NN
cord-011710-rz23ozxb	59	26	including	include	VBG
cord-011710-rz23ozxb	59	27	influenza	influenza	NN
cord-011710-rz23ozxb	59	28	during	during	IN
cord-011710-rz23ozxb	59	29	the	the	DT
cord-011710-rz23ozxb	59	30	interpandemic	interpandemic	JJ
cord-011710-rz23ozxb	59	31	period	period	NN
cord-011710-rz23ozxb	59	32	.	.	.
cord-011710-rz23ozxb	60	1	Such	such	JJ
cord-011710-rz23ozxb	60	2	initiatives	initiative	NNS
cord-011710-rz23ozxb	60	3	need	need	VBP
cord-011710-rz23ozxb	60	4	to	to	TO
cord-011710-rz23ozxb	60	5	be	be	VB
cord-011710-rz23ozxb	60	6	supported	support	VBN
cord-011710-rz23ozxb	60	7	and	and	CC
cord-011710-rz23ozxb	60	8	sustained	sustain	VBN
cord-011710-rz23ozxb	60	9	if	if	IN
cord-011710-rz23ozxb	60	10	we	-PRON-	PRP
cord-011710-rz23ozxb	60	11	are	be	VBP
cord-011710-rz23ozxb	60	12	to	to	TO
cord-011710-rz23ozxb	60	13	develop	develop	VB
cord-011710-rz23ozxb	60	14	the	the	DT
cord-011710-rz23ozxb	60	15	key	key	JJ
cord-011710-rz23ozxb	60	16	evidence	evidence	NN
cord-011710-rz23ozxb	60	17	needed	need	VBN
cord-011710-rz23ozxb	60	18	to	to	TO
cord-011710-rz23ozxb	60	19	inform	inform	VB
cord-011710-rz23ozxb	60	20	clinical	clinical	JJ
cord-011710-rz23ozxb	60	21	management	management	NN
cord-011710-rz23ozxb	60	22	for	for	IN
cord-011710-rz23ozxb	60	23	current	current	JJ
cord-011710-rz23ozxb	60	24	and	and	CC
cord-011710-rz23ozxb	60	25	future	future	JJ
cord-011710-rz23ozxb	60	26	severe	severe	JJ
cord-011710-rz23ozxb	60	27	acute	acute	JJ
cord-011710-rz23ozxb	60	28	respiratory	respiratory	JJ
cord-011710-rz23ozxb	60	29	infection	infection	NN
cord-011710-rz23ozxb	60	30	and	and	CC
cord-011710-rz23ozxb	60	31	emerging	emerge	VBG
cord-011710-rz23ozxb	60	32	infectious	infectious	JJ
cord-011710-rz23ozxb	60	33	disease	disease	NN
cord-011710-rz23ozxb	60	34	threats	threat	NNS
cord-011710-rz23ozxb	60	35	.	.	.
cord-011710-rz23ozxb	61	1	Impact	impact	NN
cord-011710-rz23ozxb	61	2	of	of	IN
cord-011710-rz23ozxb	61	3	neuraminidase	neuraminidase	JJ
cord-011710-rz23ozxb	61	4	inhibitor	inhibitor	NN
cord-011710-rz23ozxb	61	5	treatment	treatment	NN
cord-011710-rz23ozxb	61	6	on	on	IN
cord-011710-rz23ozxb	61	7	outcomes	outcome	NNS
cord-011710-rz23ozxb	61	8	of	of	IN
cord-011710-rz23ozxb	61	9	public	public	JJ
cord-011710-rz23ozxb	61	10	health	health	NN
cord-011710-rz23ozxb	61	11	importance	importance	NN
cord-011710-rz23ozxb	61	12	during	during	IN
cord-011710-rz23ozxb	61	13	the	the	DT
cord-011710-rz23ozxb	61	14	2009	2009	CD
cord-011710-rz23ozxb	61	15	-	-	SYM
cord-011710-rz23ozxb	61	16	10	10	CD
cord-011710-rz23ozxb	61	17	influenza	influenza	NN
cord-011710-rz23ozxb	61	18	A	a	NN
cord-011710-rz23ozxb	61	19	(	(	-LRB-
cord-011710-rz23ozxb	61	20	H1N1	H1N1	NNP
cord-011710-rz23ozxb	61	21	)	)	-RRB-
cord-011710-rz23ozxb	61	22	pandemic	pandemic	NN
cord-011710-rz23ozxb	61	23	:	:	:
cord-011710-rz23ozxb	61	24	a	a	DT
cord-011710-rz23ozxb	61	25	systematic	systematic	JJ
cord-011710-rz23ozxb	61	26	review	review	NN
cord-011710-rz23ozxb	61	27	and	and	CC
cord-011710-rz23ozxb	61	28	metaanalysis	metaanalysis	NN
cord-011710-rz23ozxb	61	29	in	in	IN
cord-011710-rz23ozxb	61	30	hospitalized	hospitalize	VBN
cord-011710-rz23ozxb	61	31	patients	patient	NNS
cord-011710-rz23ozxb	61	32	Antivirals	antiviral	NNS
cord-011710-rz23ozxb	61	33	for	for	IN
cord-011710-rz23ozxb	61	34	treatment	treatment	NN
cord-011710-rz23ozxb	61	35	of	of	IN
cord-011710-rz23ozxb	61	36	influenza	influenza	NN
cord-011710-rz23ozxb	61	37	A	a	DT
cord-011710-rz23ozxb	61	38	systematic	systematic	JJ
cord-011710-rz23ozxb	61	39	review	review	NN
cord-011710-rz23ozxb	61	40	and	and	CC
cord-011710-rz23ozxb	61	41	meta	meta	NNP
cord-011710-rz23ozxb	61	42	-	-	HYPH
cord-011710-rz23ozxb	61	43	analysis	analysis	NN
cord-011710-rz23ozxb	61	44	of	of	IN
cord-011710-rz23ozxb	61	45	observational	observational	JJ
cord-011710-rz23ozxb	61	46	studies	study	NNS
cord-011710-rz23ozxb	61	47	strengthening	strengthen	VBG
cord-011710-rz23ozxb	61	48	observational	observational	JJ
cord-011710-rz23ozxb	61	49	evidence	evidence	NN
cord-011710-rz23ozxb	61	50	for	for	IN
cord-011710-rz23ozxb	61	51	antiviral	antiviral	JJ
cord-011710-rz23ozxb	61	52	effectiveness	effectiveness	NN
cord-011710-rz23ozxb	61	53	in	in	IN
cord-011710-rz23ozxb	61	54	influenza	influenza	NN
cord-011710-rz23ozxb	61	55	A	a	NN
cord-011710-rz23ozxb	61	56	(	(	-LRB-
cord-011710-rz23ozxb	61	57	H5N1	H5N1	NNP
cord-011710-rz23ozxb	61	58	)	)	-RRB-
cord-011710-rz23ozxb	61	59	Determinants	determinant	NNS
cord-011710-rz23ozxb	61	60	of	of	IN
cord-011710-rz23ozxb	61	61	viral	viral	JJ
cord-011710-rz23ozxb	61	62	effectiveness	effectiveness	NN
cord-011710-rz23ozxb	61	63	in	in	IN
cord-011710-rz23ozxb	61	64	influenza	influenza	NN
cord-011710-rz23ozxb	61	65	virus	virus	NN
cord-011710-rz23ozxb	62	1	A	a	DT
cord-011710-rz23ozxb	62	2	subtype	subtype	NN
cord-011710-rz23ozxb	63	1	H5N1	H5N1	NNP
cord-011710-rz23ozxb	63	2	Impact	Impact	NNP
cord-011710-rz23ozxb	63	3	of	of	IN
cord-011710-rz23ozxb	63	4	antiviral	antiviral	JJ
cord-011710-rz23ozxb	63	5	treatment	treatment	NN
cord-011710-rz23ozxb	63	6	and	and	CC
cord-011710-rz23ozxb	63	7	hospital	hospital	NN
cord-011710-rz23ozxb	63	8	admission	admission	NN
cord-011710-rz23ozxb	63	9	delay	delay	NN
cord-011710-rz23ozxb	63	10	on	on	IN
cord-011710-rz23ozxb	63	11	risk	risk	NN
cord-011710-rz23ozxb	63	12	of	of	IN
cord-011710-rz23ozxb	63	13	death	death	NN
cord-011710-rz23ozxb	63	14	associated	associate	VBN
cord-011710-rz23ozxb	63	15	with	with	IN
cord-011710-rz23ozxb	63	16	2009	2009	CD
cord-011710-rz23ozxb	63	17	A	A	NNP
cord-011710-rz23ozxb	63	18	/	/	SYM
cord-011710-rz23ozxb	63	19	H1N1	H1N1	NNP
cord-011710-rz23ozxb	63	20	pandemic	pandemic	NN
cord-011710-rz23ozxb	63	21	influenza	influenza	NN
cord-011710-rz23ozxb	63	22	in	in	IN
cord-011710-rz23ozxb	63	23	Mexico	Mexico	NNP
cord-011710-rz23ozxb	63	24	Transmission	Transmission	NNP
cord-011710-rz23ozxb	63	25	dynamics	dynamic	NNS
cord-011710-rz23ozxb	63	26	and	and	CC
cord-011710-rz23ozxb	63	27	impact	impact	NN
cord-011710-rz23ozxb	63	28	of	of	IN
cord-011710-rz23ozxb	63	29	pandemic	pandemic	NN
cord-011710-rz23ozxb	63	30	influenza	influenza	NN
cord-011710-rz23ozxb	63	31	A	a	NN
cord-011710-rz23ozxb	63	32	(	(	-LRB-
cord-011710-rz23ozxb	63	33	H1N1	H1N1	NNP
cord-011710-rz23ozxb	63	34	)	)	-RRB-
cord-011710-rz23ozxb	63	35	2009	2009	CD
cord-011710-rz23ozxb	63	36	virus	virus	NN
cord-011710-rz23ozxb	63	37	Review	Review	NNP
cord-011710-rz23ozxb	63	38	of	of	IN
cord-011710-rz23ozxb	63	39	the	the	DT
cord-011710-rz23ozxb	63	40	pandemic	pandemic	NN
cord-011710-rz23ozxb	63	41	(	(	-LRB-
cord-011710-rz23ozxb	63	42	H1N1	H1N1	NNP
cord-011710-rz23ozxb	63	43	)	)	-RRB-
cord-011710-rz23ozxb	64	1	2009	2009	CD
cord-011710-rz23ozxb	65	1	among	among	IN
cord-011710-rz23ozxb	65	2	pregnant	pregnant	JJ
cord-011710-rz23ozxb	65	3	Japanese	japanese	JJ
cord-011710-rz23ozxb	65	4	women	woman	NNS
cord-011710-rz23ozxb	65	5	Supply	Supply	NNP
cord-011710-rz23ozxb	65	6	of	of	IN
cord-011710-rz23ozxb	65	7	neuraminidase	neuraminidase	NN
cord-011710-rz23ozxb	65	8	inhibitors	inhibitor	NNS
cord-011710-rz23ozxb	65	9	related	relate	VBN
cord-011710-rz23ozxb	65	10	to	to	IN
cord-011710-rz23ozxb	65	11	reduced	reduce	VBN
cord-011710-rz23ozxb	65	12	influenza	influenza	NN
cord-011710-rz23ozxb	65	13	A	a	NN
cord-011710-rz23ozxb	65	14	(	(	-LRB-
cord-011710-rz23ozxb	65	15	H1N1	H1N1	NNP
cord-011710-rz23ozxb	65	16	)	)	-RRB-
cord-011710-rz23ozxb	65	17	mortality	mortality	NN
cord-011710-rz23ozxb	65	18	during	during	IN
cord-011710-rz23ozxb	65	19	the	the	DT
cord-011710-rz23ozxb	65	20	2009	2009	CD
cord-011710-rz23ozxb	65	21	-	-	SYM
cord-011710-rz23ozxb	65	22	2010	2010	CD
cord-011710-rz23ozxb	65	23	H1N1	H1N1	NNP
cord-011710-rz23ozxb	65	24	pandemic	pandemic	NN
cord-011710-rz23ozxb	65	25	:	:	:
cord-011710-rz23ozxb	65	26	an	an	DT
cord-011710-rz23ozxb	65	27	ecological	ecological	JJ
cord-011710-rz23ozxb	65	28	study	study	NN
cord-011710-rz23ozxb	65	29	Treatment	treatment	NN
cord-011710-rz23ozxb	65	30	with	with	IN
cord-011710-rz23ozxb	65	31	neuraminidase	neuraminidase	FW
cord-011710-rz23ozxb	65	32	inhibitors	inhibitor	NNS
cord-011710-rz23ozxb	65	33	for	for	IN
cord-011710-rz23ozxb	65	34	critically	critically	RB
cord-011710-rz23ozxb	65	35	ill	ill	JJ
cord-011710-rz23ozxb	65	36	patients	patient	NNS
cord-011710-rz23ozxb	65	37	with	with	IN
cord-011710-rz23ozxb	65	38	influenza	influenza	NN
cord-011710-rz23ozxb	65	39	A	a	NN
cord-011710-rz23ozxb	65	40	(	(	-LRB-
cord-011710-rz23ozxb	66	1	H1N1	H1N1	NNP
cord-011710-rz23ozxb	66	2	)	)	-RRB-
cord-011710-rz23ozxb	66	3	pdm09	pdm09	NNP
cord-011710-rz23ozxb	66	4	Antiviral	antiviral	JJ
cord-011710-rz23ozxb	66	5	therapy	therapy	NN
cord-011710-rz23ozxb	66	6	and	and	CC
cord-011710-rz23ozxb	66	7	outcomes	outcome	NNS
cord-011710-rz23ozxb	66	8	of	of	IN
cord-011710-rz23ozxb	66	9	patients	patient	NNS
cord-011710-rz23ozxb	66	10	with	with	IN
cord-011710-rz23ozxb	66	11	pneumonia	pneumonia	NN
cord-011710-rz23ozxb	66	12	caused	cause	VBN
cord-011710-rz23ozxb	66	13	by	by	IN
cord-011710-rz23ozxb	66	14	influenza	influenza	NN
cord-011710-rz23ozxb	66	15	A	a	NN
cord-011710-rz23ozxb	67	1	pandemic	pandemic	NNP
cord-011710-rz23ozxb	67	2	(	(	-LRB-
cord-011710-rz23ozxb	67	3	H1N1	H1N1	NNP
cord-011710-rz23ozxb	67	4	)	)	-RRB-
cord-011710-rz23ozxb	67	5	virus	virus	NN
cord-011710-rz23ozxb	67	6	Pandemic	Pandemic	NNP
cord-011710-rz23ozxb	67	7	2009	2009	CD
cord-011710-rz23ozxb	67	8	influenza	influenza	NN
cord-011710-rz23ozxb	67	9	A	a	NN
cord-011710-rz23ozxb	67	10	(	(	-LRB-
cord-011710-rz23ozxb	67	11	H1N1	H1N1	NNP
cord-011710-rz23ozxb	67	12	)	)	-RRB-
cord-011710-rz23ozxb	67	13	virus	virus	NN
cord-011710-rz23ozxb	67	14	illness	illness	NN
cord-011710-rz23ozxb	67	15	among	among	IN
cord-011710-rz23ozxb	67	16	pregnant	pregnant	JJ
cord-011710-rz23ozxb	67	17	women	woman	NNS
cord-011710-rz23ozxb	67	18	in	in	IN
cord-011710-rz23ozxb	67	19	the	the	DT
cord-011710-rz23ozxb	67	20	United	United	NNP
cord-011710-rz23ozxb	67	21	States	States	NNP
cord-011710-rz23ozxb	67	22	Viral	Viral	NNP
cord-011710-rz23ozxb	67	23	clearance	clearance	NN
cord-011710-rz23ozxb	67	24	and	and	CC
cord-011710-rz23ozxb	67	25	inflammatory	inflammatory	JJ
cord-011710-rz23ozxb	67	26	response	response	NN
cord-011710-rz23ozxb	67	27	patterns	pattern	NNS
cord-011710-rz23ozxb	67	28	in	in	IN
cord-011710-rz23ozxb	67	29	adults	adult	NNS
cord-011710-rz23ozxb	67	30	hospitalized	hospitalize	VBN
cord-011710-rz23ozxb	67	31	for	for	IN
cord-011710-rz23ozxb	67	32	pandemic	pandemic	NN
cord-011710-rz23ozxb	68	1	A	a	DT
cord-011710-rz23ozxb	68	2	(	(	-LRB-
cord-011710-rz23ozxb	68	3	H1N1	H1N1	NNP
cord-011710-rz23ozxb	68	4	)	)	-RRB-
cord-011710-rz23ozxb	68	5	virus	virus	NN
cord-011710-rz23ozxb	68	6	pneumonia	pneumonia	NN
cord-011710-rz23ozxb	69	1	The	the	DT
cord-011710-rz23ozxb	69	2	natural	natural	JJ
cord-011710-rz23ozxb	69	3	viral	viral	JJ
cord-011710-rz23ozxb	69	4	load	load	NN
cord-011710-rz23ozxb	69	5	profile	profile	NN
cord-011710-rz23ozxb	69	6	of	of	IN
cord-011710-rz23ozxb	69	7	patients	patient	NNS
cord-011710-rz23ozxb	69	8	with	with	IN
cord-011710-rz23ozxb	69	9	pandemic	pandemic	NN
cord-011710-rz23ozxb	69	10	2009	2009	CD
cord-011710-rz23ozxb	69	11	influenza	influenza	NN
cord-011710-rz23ozxb	69	12	A	a	NN
cord-011710-rz23ozxb	69	13	(	(	-LRB-
cord-011710-rz23ozxb	69	14	H1N1	H1N1	NNP
cord-011710-rz23ozxb	69	15	)	)	-RRB-
cord-011710-rz23ozxb	69	16	and	and	CC
cord-011710-rz23ozxb	69	17	the	the	DT
cord-011710-rz23ozxb	69	18	effect	effect	NN
cord-011710-rz23ozxb	69	19	of	of	IN
cord-011710-rz23ozxb	69	20	oseltamivir	oseltamivir	NN
cord-011710-rz23ozxb	69	21	treatment	treatment	NN
cord-011710-rz23ozxb	69	22	Therapuetic	Therapuetic	NNP
cord-011710-rz23ozxb	69	23	effectiveness	effectiveness	NN
cord-011710-rz23ozxb	69	24	of	of	IN
cord-011710-rz23ozxb	69	25	amantadine	amantadine	NNP
cord-011710-rz23ozxb	69	26	hydrochloride	hydrochloride	NN
cord-011710-rz23ozxb	69	27	in	in	IN
cord-011710-rz23ozxb	69	28	naturally	naturally	RB
cord-011710-rz23ozxb	69	29	occurring	occur	VBG
cord-011710-rz23ozxb	69	30	Hong	Hong	NNP
cord-011710-rz23ozxb	69	31	Kong	Kong	NNP
cord-011710-rz23ozxb	69	32	influenza	influenza	NN
cord-011710-rz23ozxb	69	33	-	-	HYPH
cord-011710-rz23ozxb	69	34	double	double	JJ
cord-011710-rz23ozxb	69	35	blind	blind	JJ
cord-011710-rz23ozxb	69	36	studies	study	NNS
cord-011710-rz23ozxb	69	37	Amantadine	Amantadine	NNP
cord-011710-rz23ozxb	69	38	therapy	therapy	NN
cord-011710-rz23ozxb	69	39	of	of	IN
cord-011710-rz23ozxb	69	40	epidemic	epidemic	NN
cord-011710-rz23ozxb	70	1	influenza	influenza	NNP
cord-011710-rz23ozxb	70	2	A	A	NNP
cord-011710-rz23ozxb	70	3	(	(	-LRB-
cord-011710-rz23ozxb	70	4	Hong	Hong	NNP
cord-011710-rz23ozxb	70	5	Kong	Kong	NNP
cord-011710-rz23ozxb	70	6	)	)	-RRB-
cord-011710-rz23ozxb	71	1	Successful	successful	JJ
cord-011710-rz23ozxb	71	2	treatment	treatment	NN
cord-011710-rz23ozxb	71	3	of	of	IN
cord-011710-rz23ozxb	71	4	naturally	naturally	RB
cord-011710-rz23ozxb	71	5	occurring	occur	VBG
cord-011710-rz23ozxb	71	6	influenza	influenza	NN
cord-011710-rz23ozxb	71	7	A	a	NN
cord-011710-rz23ozxb	71	8	/	/	SYM
cord-011710-rz23ozxb	71	9	USSR/77	ussr/77	JJ
cord-011710-rz23ozxb	71	10	H1N1	H1N1	NNP
cord-011710-rz23ozxb	71	11	End	End	NNP
cord-011710-rz23ozxb	71	12	points	point	NNS
cord-011710-rz23ozxb	71	13	for	for	IN
cord-011710-rz23ozxb	71	14	testing	test	VBG
cord-011710-rz23ozxb	71	15	influenza	influenza	NN
cord-011710-rz23ozxb	71	16	antiviral	antiviral	JJ
cord-011710-rz23ozxb	71	17	treatments	treatment	NNS
cord-011710-rz23ozxb	71	18	for	for	IN
cord-011710-rz23ozxb	71	19	patients	patient	NNS
cord-011710-rz23ozxb	71	20	at	at	IN
cord-011710-rz23ozxb	71	21	high	high	JJ
cord-011710-rz23ozxb	71	22	risk	risk	NN
cord-011710-rz23ozxb	71	23	of	of	IN
cord-011710-rz23ozxb	71	24	severe	severe	JJ
cord-011710-rz23ozxb	71	25	and	and	CC
cord-011710-rz23ozxb	71	26	life	life	NN
cord-011710-rz23ozxb	71	27	-	-	HYPH
cord-011710-rz23ozxb	71	28	threatening	threaten	VBG
cord-011710-rz23ozxb	71	29	disease	disease	NN
cord-011710-rz23ozxb	71	30	Fatal	fatal	JJ
cord-011710-rz23ozxb	71	31	cases	case	NNS
cord-011710-rz23ozxb	71	32	of	of	IN
cord-011710-rz23ozxb	71	33	pandemic	pandemic	NN
cord-011710-rz23ozxb	71	34	(	(	-LRB-
cord-011710-rz23ozxb	71	35	H1N1	H1N1	NNP
cord-011710-rz23ozxb	71	36	)	)	-RRB-
cord-011710-rz23ozxb	72	1	2009	2009	CD
cord-011710-rz23ozxb	72	2	influenza	influenza	NN
cord-011710-rz23ozxb	72	3	despite	despite	IN
cord-011710-rz23ozxb	72	4	their	-PRON-	PRP$
cord-011710-rz23ozxb	72	5	early	early	JJ
cord-011710-rz23ozxb	72	6	antiviral	antiviral	JJ
cord-011710-rz23ozxb	72	7	treatment	treatment	NN
cord-011710-rz23ozxb	72	8	in	in	IN
cord-011710-rz23ozxb	72	9	Japan	Japan	NNP
cord-011710-rz23ozxb	72	10	Triple	Triple	NNP
cord-011710-rz23ozxb	72	11	combination	combination	NN
cord-011710-rz23ozxb	72	12	of	of	IN
cord-011710-rz23ozxb	72	13	amantadine	amantadine	NN
cord-011710-rz23ozxb	72	14	,	,	,
cord-011710-rz23ozxb	72	15	ribavirin	ribavirin	NN
cord-011710-rz23ozxb	72	16	,	,	,
cord-011710-rz23ozxb	72	17	and	and	CC
cord-011710-rz23ozxb	72	18	oseltamivir	oseltamivir	NN
cord-011710-rz23ozxb	72	19	is	be	VBZ
cord-011710-rz23ozxb	72	20	highly	highly	RB
cord-011710-rz23ozxb	72	21	active	active	JJ
cord-011710-rz23ozxb	72	22	and	and	CC
cord-011710-rz23ozxb	72	23	synergistic	synergistic	JJ
cord-011710-rz23ozxb	72	24	against	against	IN
cord-011710-rz23ozxb	72	25	drug	drug	NN
cord-011710-rz23ozxb	72	26	resistant	resistant	JJ
cord-011710-rz23ozxb	72	27	influenza	influenza	NN
cord-011710-rz23ozxb	72	28	virus	virus	NN
cord-011710-rz23ozxb	72	29	strains	strain	NNS
cord-011710-rz23ozxb	72	30	in	in	IN
cord-011710-rz23ozxb	72	31	vitro	vitro	FW
cord-011710-rz23ozxb	72	32	Efficacy	Efficacy	NNP
cord-011710-rz23ozxb	72	33	of	of	IN
cord-011710-rz23ozxb	72	34	oseltamivir	oseltamivir	NNP
cord-011710-rz23ozxb	72	35	-	-	HYPH
cord-011710-rz23ozxb	72	36	zanamivir	zanamivir	NNP
cord-011710-rz23ozxb	72	37	combination	combination	NN
cord-011710-rz23ozxb	72	38	compared	compare	VBN
cord-011710-rz23ozxb	72	39	to	to	IN
cord-011710-rz23ozxb	72	40	each	each	DT
cord-011710-rz23ozxb	72	41	monotherapy	monotherapy	NN
cord-011710-rz23ozxb	72	42	for	for	IN
cord-011710-rz23ozxb	72	43	seasonal	seasonal	JJ
cord-011710-rz23ozxb	72	44	influenza	influenza	NN
cord-011710-rz23ozxb	72	45	:	:	:
cord-011710-rz23ozxb	72	46	a	a	DT
cord-011710-rz23ozxb	72	47	randomized	randomized	JJ
cord-011710-rz23ozxb	72	48	placebocontrolled	placebocontrolled	JJ
cord-011710-rz23ozxb	72	49	trial	trial	NN
cord-011710-rz23ozxb	72	50	Pandemic	Pandemic	NNP
cord-011710-rz23ozxb	72	51	versus	versus	IN
cord-011710-rz23ozxb	72	52	epidemic	epidemic	NN
cord-011710-rz23ozxb	72	53	influenza	influenza	NN
cord-011710-rz23ozxb	72	54	mortality	mortality	NN
cord-011710-rz23ozxb	72	55	:	:	:
cord-011710-rz23ozxb	72	56	a	a	DT
cord-011710-rz23ozxb	72	57	pattern	pattern	NN
cord-011710-rz23ozxb	72	58	of	of	IN
cord-011710-rz23ozxb	72	59	changing	change	VBG
cord-011710-rz23ozxb	72	60	age	age	NN
cord-011710-rz23ozxb	72	61	distribution	distribution	NN
cord-011710-rz23ozxb	72	62	Reduced	reduce	VBN
cord-011710-rz23ozxb	72	63	influenza	influenza	NN
cord-011710-rz23ozxb	72	64	antiviral	antiviral	JJ
cord-011710-rz23ozxb	72	65	treatment	treatment	NN
cord-011710-rz23ozxb	72	66	among	among	IN
cord-011710-rz23ozxb	72	67	children	child	NNS
cord-011710-rz23ozxb	72	68	and	and	CC
cord-011710-rz23ozxb	72	69	adults	adult	NNS
cord-011710-rz23ozxb	72	70	hospitalized	hospitalize	VBN
cord-011710-rz23ozxb	72	71	with	with	IN
cord-011710-rz23ozxb	72	72	laboratoryconfirmed	laboratoryconfirme	VBN
cord-011710-rz23ozxb	72	73	influenza	influenza	NN
cord-011710-rz23ozxb	72	74	infection	infection	NN
cord-011710-rz23ozxb	72	75	in	in	IN
cord-011710-rz23ozxb	72	76	the	the	DT
cord-011710-rz23ozxb	72	77	year	year	NN
cord-011710-rz23ozxb	72	78	after	after	IN
cord-011710-rz23ozxb	72	79	the	the	DT
cord-011710-rz23ozxb	72	80	2009	2009	CD
cord-011710-rz23ozxb	72	81	pandemic	pandemic	NN
cord-011710-rz23ozxb	72	82	International	International	NNP
cord-011710-rz23ozxb	72	83	Severe	Severe	NNP
cord-011710-rz23ozxb	72	84	Acute	acute	JJ
cord-011710-rz23ozxb	72	85	Respiratory	Respiratory	NNP
cord-011710-rz23ozxb	72	86	Infection	Infection	NNP
cord-011710-rz23ozxb	72	87	Consortium	Consortium	NNP
cord-011710-rz23ozxb	72	88	Web	web	NN
cord-011710-rz23ozxb	72	89	site	site	NN
cord-011710-rz23ozxb	72	90	Potential	potential	JJ
cord-011710-rz23ozxb	72	91	conflicts	conflict	NNS
cord-011710-rz23ozxb	72	92	of	of	IN
cord-011710-rz23ozxb	72	93	interest	interest	NN
cord-011710-rz23ozxb	72	94	.	.	.
cord-011710-rz23ozxb	73	1	F.	F.	NNP
cord-011710-rz23ozxb	73	2	G.	G.	NNP
cord-011710-rz23ozxb	73	3	H.	H.	NNP
cord-011710-rz23ozxb	73	4	has	have	VBZ
cord-011710-rz23ozxb	73	5	served	serve	VBN
cord-011710-rz23ozxb	73	6	as	as	IN
cord-011710-rz23ozxb	73	7	an	an	DT
cord-011710-rz23ozxb	73	8	unpaid	unpaid	JJ
cord-011710-rz23ozxb	73	9	consultant	consultant	NN
cord-011710-rz23ozxb	73	10	to	to	IN
cord-011710-rz23ozxb	73	11	multiple	multiple	JJ
cord-011710-rz23ozxb	73	12	companies	company	NNS
cord-011710-rz23ozxb	73	13	involved	involve	VBN
cord-011710-rz23ozxb	73	14	in	in	IN
cord-011710-rz23ozxb	73	15	influenza	influenza	JJ
cord-011710-rz23ozxb	73	16	antiviral	antiviral	JJ
cord-011710-rz23ozxb	73	17	development	development	NN
cord-011710-rz23ozxb	73	18	(	(	-LRB-
cord-011710-rz23ozxb	73	19	including	include	VBG
cord-011710-rz23ozxb	73	20	Roche	Roche	NNP
cord-011710-rz23ozxb	73	21	,	,	,
cord-011710-rz23ozxb	73	22	GlaxoSmithKline	GlaxoSmithKline	NNP
cord-011710-rz23ozxb	73	23	,	,	,
cord-011710-rz23ozxb	73	24	Bio	Bio	NNP
cord-011710-rz23ozxb	73	25	-	-	HYPH
cord-011710-rz23ozxb	73	26	Cryst	Cryst	NNP
cord-011710-rz23ozxb	73	27	,	,	,
cord-011710-rz23ozxb	73	28	Nexbio	Nexbio	NNP
cord-011710-rz23ozxb	73	29	,	,	,
cord-011710-rz23ozxb	73	30	Toyama	Toyama	NNP
cord-011710-rz23ozxb	73	31	)	)	-RRB-
cord-011710-rz23ozxb	73	32	.	.	.
cord-011710-rz23ozxb	74	1	The	the	DT
cord-011710-rz23ozxb	74	2	University	University	NNP
cord-011710-rz23ozxb	74	3	of	of	IN
cord-011710-rz23ozxb	74	4	Virginia	Virginia	NNP
cord-011710-rz23ozxb	74	5	received	receive	VBD
cord-011710-rz23ozxb	74	6	honoraria	honorarium	NNS
cord-011710-rz23ozxb	74	7	for	for	IN
cord-011710-rz23ozxb	74	8	his	-PRON-	PRP$
cord-011710-rz23ozxb	74	9	work	work	NN
cord-011710-rz23ozxb	74	10	in	in	IN
cord-011710-rz23ozxb	74	11	the	the	DT
cord-011710-rz23ozxb	74	12	Neuraminidase	Neuraminidase	NNP
cord-011710-rz23ozxb	74	13	Inhibitor	Inhibitor	NNP
cord-011710-rz23ozxb	74	14	Susceptibility	Susceptibility	NNP
cord-011710-rz23ozxb	74	15	Network	Network	NNP
cord-011710-rz23ozxb	74	16	(	(	-LRB-
cord-011710-rz23ozxb	74	17	NISN	NISN	NNP
cord-011710-rz23ozxb	74	18	)	)	-RRB-
cord-011710-rz23ozxb	74	19	from	from	IN
cord-011710-rz23ozxb	74	20	2008	2008	CD
cord-011710-rz23ozxb	74	21	to	to	IN
cord-011710-rz23ozxb	74	22	2011	2011	CD
cord-011710-rz23ozxb	74	23	;	;	:
cord-011710-rz23ozxb	74	24	NISN	NISN	NNP
cord-011710-rz23ozxb	74	25	received	receive	VBD
cord-011710-rz23ozxb	74	26	financial	financial	JJ
cord-011710-rz23ozxb	74	27	support	support	NN
cord-011710-rz23ozxb	74	28	from	from	IN
cord-011710-rz23ozxb	74	29	Roche	Roche	NNP
cord-011710-rz23ozxb	74	30	and	and	CC
cord-011710-rz23ozxb	74	31	GlaxoSmith	GlaxoSmith	NNP
cord-011710-rz23ozxb	74	32	-	-	HYPH
cord-011710-rz23ozxb	74	33	Kline	Kline	NNP
cord-011710-rz23ozxb	74	34	.	.	.
cord-011710-rz23ozxb	75	1	F.	F.	NNP
cord-011710-rz23ozxb	75	2	Y.	Y.	NNP
cord-011710-rz23ozxb	75	3	A.	a.	NN
cord-011710-rz23ozxb	75	4	reports	report	VBZ
cord-011710-rz23ozxb	75	5	no	no	DT
cord-011710-rz23ozxb	75	6	potential	potential	JJ
cord-011710-rz23ozxb	75	7	conflicts	conflict	NNS
cord-011710-rz23ozxb	75	8	.	.	.
cord-011710-rz23ozxb	76	1	All	all	DT
cord-011710-rz23ozxb	76	2	authors	author	NNS
cord-011710-rz23ozxb	76	3	have	have	VBP
cord-011710-rz23ozxb	76	4	submitted	submit	VBN
cord-011710-rz23ozxb	76	5	the	the	DT
cord-011710-rz23ozxb	76	6	ICMJE	ICMJE	NNP
cord-011710-rz23ozxb	76	7	Form	Form	NNP
cord-011710-rz23ozxb	76	8	for	for	IN
cord-011710-rz23ozxb	76	9	Disclosure	Disclosure	NNP
cord-011710-rz23ozxb	76	10	of	of	IN
cord-011710-rz23ozxb	76	11	Potential	potential	JJ
cord-011710-rz23ozxb	76	12	Conflicts	conflict	NNS
cord-011710-rz23ozxb	76	13	of	of	IN
cord-011710-rz23ozxb	76	14	Interest	interest	NN
cord-011710-rz23ozxb	76	15	.	.	.
cord-011710-rz23ozxb	77	1	Conflicts	conflict	NNS
cord-011710-rz23ozxb	77	2	that	that	WDT
cord-011710-rz23ozxb	77	3	the	the	DT
cord-011710-rz23ozxb	77	4	editors	editor	NNS
cord-011710-rz23ozxb	77	5	consider	consider	VBP
cord-011710-rz23ozxb	77	6	relevant	relevant	JJ
cord-011710-rz23ozxb	77	7	to	to	IN
cord-011710-rz23ozxb	77	8	the	the	DT
cord-011710-rz23ozxb	77	9	content	content	NN
cord-011710-rz23ozxb	77	10	of	of	IN
cord-011710-rz23ozxb	77	11	the	the	DT
cord-011710-rz23ozxb	77	12	manuscript	manuscript	NN
cord-011710-rz23ozxb	77	13	have	have	VBP
cord-011710-rz23ozxb	77	14	been	be	VBN
cord-011710-rz23ozxb	77	15	disclosed	disclose	VBN
cord-011710-rz23ozxb	77	16	.	.	.