id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-260856-15k7pkh5	Buchanan, Sarah M.	Olfactory testing does not predict β-amyloid, MRI measures of neurodegeneration or vascular pathology in the British 1946 birth cohort	2020-06-24		.txt	text/plain	2401	127	46	OBJECTIVE: To explore the value of olfactory identification deficits as a predictor of cerebral β-amyloid status and other markers of brain health in cognitively normal adults aged ~ 70 years. 389 largely healthy and cognitively normal older adults were recruited from the MRC National Survey of Health and Development (1946 British Birth cohort) and investigated for olfactory identification deficits, as measured by the University of Pennsylvania Smell Identification Test. Outcome measures were imaging markers of brain health derived from 3 T MRI scanning (cortical thickness, entorhinal cortex thickness, white matter hyperintensity volumes); (18)F florbetapir amyloid-PET scanning; and cognitive testing results. In the current study, we explored associations between OI and markers of cerebral β-amyloid deposition (using 18 F-florbetapir PET scanning), neurodegeneration, and cognition in a uniquely well-characterised cohort of near identical age drawn from the MRC National Survey of Health and Development (NSHD; the British 1946 birth cohort).	./cache/cord-260856-15k7pkh5.txt	./txt/cord-260856-15k7pkh5.txt