id sid tid token lemma pos cord-011302-pfepyvaw 1 1 key key JJ cord-011302-pfepyvaw 1 2 : : : cord-011302-pfepyvaw 1 3 cord-011302-pfepyvaw cord-011302-pfepyvaw JJ cord-011302-pfepyvaw 1 4 authors author NNS cord-011302-pfepyvaw 1 5 : : : cord-011302-pfepyvaw 1 6 Edlmann Edlmann NNP cord-011302-pfepyvaw 1 7 , , , cord-011302-pfepyvaw 1 8 Ellie Ellie NNP cord-011302-pfepyvaw 1 9 ; ; : cord-011302-pfepyvaw 1 10 Whitfield Whitfield NNP cord-011302-pfepyvaw 1 11 , , , cord-011302-pfepyvaw 1 12 Peter Peter NNP cord-011302-pfepyvaw 1 13 C. C. NNP cord-011302-pfepyvaw 1 14 title title NN cord-011302-pfepyvaw 1 15 : : : cord-011302-pfepyvaw 1 16 The the DT cord-011302-pfepyvaw 1 17 changing change VBG cord-011302-pfepyvaw 1 18 face face NN cord-011302-pfepyvaw 1 19 of of IN cord-011302-pfepyvaw 1 20 neurosurgery neurosurgery NN cord-011302-pfepyvaw 1 21 for for IN cord-011302-pfepyvaw 1 22 the the DT cord-011302-pfepyvaw 1 23 older old JJR cord-011302-pfepyvaw 1 24 person person NN cord-011302-pfepyvaw 1 25 date date NN cord-011302-pfepyvaw 1 26 : : : cord-011302-pfepyvaw 1 27 2020 2020 CD cord-011302-pfepyvaw 1 28 - - HYPH cord-011302-pfepyvaw 1 29 04 04 CD cord-011302-pfepyvaw 1 30 - - SYM cord-011302-pfepyvaw 1 31 25 25 CD cord-011302-pfepyvaw 1 32 journal journal NN cord-011302-pfepyvaw 1 33 : : : cord-011302-pfepyvaw 2 1 J J NNP cord-011302-pfepyvaw 2 2 Neurol Neurol NNP cord-011302-pfepyvaw 2 3 DOI DOI NNP cord-011302-pfepyvaw 2 4 : : : cord-011302-pfepyvaw 3 1 10.1007 10.1007 CD cord-011302-pfepyvaw 3 2 / / SYM cord-011302-pfepyvaw 3 3 s00415 s00415 NN cord-011302-pfepyvaw 3 4 - - HYPH cord-011302-pfepyvaw 3 5 020 020 CD cord-011302-pfepyvaw 3 6 - - HYPH cord-011302-pfepyvaw 3 7 09854 09854 CD cord-011302-pfepyvaw 3 8 - - SYM cord-011302-pfepyvaw 3 9 9 9 CD cord-011302-pfepyvaw 3 10 sha sha NNP cord-011302-pfepyvaw 3 11 : : : cord-011302-pfepyvaw 3 12 717b69885ef54ac00216d998646fb04936ab51a9 717b69885ef54ac00216d998646fb04936ab51a9 NNP cord-011302-pfepyvaw 3 13 doc_id doc_id NNP cord-011302-pfepyvaw 3 14 : : : cord-011302-pfepyvaw 3 15 11302 11302 CD cord-011302-pfepyvaw 3 16 cord_uid cord_uid NNS cord-011302-pfepyvaw 3 17 : : : cord-011302-pfepyvaw 3 18 pfepyvaw pfepyvaw JJ cord-011302-pfepyvaw 3 19 Increased increased JJ cord-011302-pfepyvaw 3 20 life life NN cord-011302-pfepyvaw 3 21 expectancy expectancy NN cord-011302-pfepyvaw 3 22 and and CC cord-011302-pfepyvaw 3 23 illness illness NN cord-011302-pfepyvaw 3 24 prevention prevention NN cord-011302-pfepyvaw 3 25 and and CC cord-011302-pfepyvaw 3 26 treatment treatment NN cord-011302-pfepyvaw 3 27 have have VBP cord-011302-pfepyvaw 3 28 led lead VBN cord-011302-pfepyvaw 3 29 to to IN cord-011302-pfepyvaw 3 30 a a DT cord-011302-pfepyvaw 3 31 growing grow VBG cord-011302-pfepyvaw 3 32 population population NN cord-011302-pfepyvaw 3 33 of of IN cord-011302-pfepyvaw 3 34 older old JJR cord-011302-pfepyvaw 3 35 patients patient NNS cord-011302-pfepyvaw 3 36 . . . cord-011302-pfepyvaw 4 1 These these DT cord-011302-pfepyvaw 4 2 changes change NNS cord-011302-pfepyvaw 4 3 in in IN cord-011302-pfepyvaw 4 4 patient patient JJ cord-011302-pfepyvaw 4 5 population population NN cord-011302-pfepyvaw 4 6 are be VBP cord-011302-pfepyvaw 4 7 apparent apparent JJ cord-011302-pfepyvaw 4 8 in in IN cord-011302-pfepyvaw 4 9 neurosurgery neurosurgery NNP cord-011302-pfepyvaw 4 10 ; ; : cord-011302-pfepyvaw 4 11 however however RB cord-011302-pfepyvaw 4 12 , , , cord-011302-pfepyvaw 4 13 relatively relatively RB cord-011302-pfepyvaw 4 14 little little JJ cord-011302-pfepyvaw 4 15 is be VBZ cord-011302-pfepyvaw 4 16 reported report VBN cord-011302-pfepyvaw 4 17 about about IN cord-011302-pfepyvaw 4 18 specific specific JJ cord-011302-pfepyvaw 4 19 outcomes outcome NNS cord-011302-pfepyvaw 4 20 and and CC cord-011302-pfepyvaw 4 21 prognostication prognostication NN cord-011302-pfepyvaw 4 22 in in IN cord-011302-pfepyvaw 4 23 this this DT cord-011302-pfepyvaw 4 24 group group NN cord-011302-pfepyvaw 4 25 . . . cord-011302-pfepyvaw 5 1 This this DT cord-011302-pfepyvaw 5 2 review review NN cord-011302-pfepyvaw 5 3 summarises summarise VBZ cord-011302-pfepyvaw 5 4 the the DT cord-011302-pfepyvaw 5 5 challenges challenge NNS cord-011302-pfepyvaw 5 6 and and CC cord-011302-pfepyvaw 5 7 management management NN cord-011302-pfepyvaw 5 8 changes change NNS cord-011302-pfepyvaw 5 9 occurring occur VBG cord-011302-pfepyvaw 5 10 in in IN cord-011302-pfepyvaw 5 11 the the DT cord-011302-pfepyvaw 5 12 treatment treatment NN cord-011302-pfepyvaw 5 13 of of IN cord-011302-pfepyvaw 5 14 three three CD cord-011302-pfepyvaw 5 15 common common JJ cord-011302-pfepyvaw 5 16 neurosurgical neurosurgical JJ cord-011302-pfepyvaw 5 17 pathologies pathology NNS cord-011302-pfepyvaw 5 18 ; ; , cord-011302-pfepyvaw 5 19 aneurysmal aneurysmal NNP cord-011302-pfepyvaw 5 20 subarachnoid subarachnoid NN cord-011302-pfepyvaw 5 21 haemorrhage haemorrhage NN cord-011302-pfepyvaw 5 22 , , , cord-011302-pfepyvaw 5 23 head head NN cord-011302-pfepyvaw 5 24 injury injury NN cord-011302-pfepyvaw 5 25 , , , cord-011302-pfepyvaw 5 26 and and CC cord-011302-pfepyvaw 5 27 haemorrhagic haemorrhagic JJ cord-011302-pfepyvaw 5 28 stroke stroke NN cord-011302-pfepyvaw 5 29 . . . cord-011302-pfepyvaw 6 1 A a DT cord-011302-pfepyvaw 6 2 move move NN cord-011302-pfepyvaw 6 3 towards towards IN cord-011302-pfepyvaw 6 4 less less RBR cord-011302-pfepyvaw 6 5 invasive invasive JJ cord-011302-pfepyvaw 6 6 neurosurgical neurosurgical JJ cord-011302-pfepyvaw 6 7 techniques technique NNS cord-011302-pfepyvaw 6 8 has have VBZ cord-011302-pfepyvaw 6 9 implications implication NNS cord-011302-pfepyvaw 6 10 on on IN cord-011302-pfepyvaw 6 11 the the DT cord-011302-pfepyvaw 6 12 risk risk NN cord-011302-pfepyvaw 6 13 – – : cord-011302-pfepyvaw 6 14 benefit benefit NN cord-011302-pfepyvaw 6 15 profile profile NN cord-011302-pfepyvaw 6 16 of of IN cord-011302-pfepyvaw 6 17 interventions intervention NNS cord-011302-pfepyvaw 6 18 . . . cord-011302-pfepyvaw 7 1 This this DT cord-011302-pfepyvaw 7 2 creates create VBZ cord-011302-pfepyvaw 7 3 the the DT cord-011302-pfepyvaw 7 4 opportunity opportunity NN cord-011302-pfepyvaw 7 5 to to TO cord-011302-pfepyvaw 7 6 intervene intervene VB cord-011302-pfepyvaw 7 7 in in IN cord-011302-pfepyvaw 7 8 older old JJR cord-011302-pfepyvaw 7 9 patients patient NNS cord-011302-pfepyvaw 7 10 with with IN cord-011302-pfepyvaw 7 11 greater great JJR cord-011302-pfepyvaw 7 12 co co NN cord-011302-pfepyvaw 7 13 - - NN cord-011302-pfepyvaw 7 14 morbidity morbidity JJ cord-011302-pfepyvaw 7 15 , , , cord-011302-pfepyvaw 7 16 as as RB cord-011302-pfepyvaw 7 17 long long RB cord-011302-pfepyvaw 7 18 as as IN cord-011302-pfepyvaw 7 19 improved improve VBN cord-011302-pfepyvaw 7 20 outcomes outcome NNS cord-011302-pfepyvaw 7 21 can can MD cord-011302-pfepyvaw 7 22 be be VB cord-011302-pfepyvaw 7 23 evidenced evidence VBN cord-011302-pfepyvaw 7 24 . . . cord-011302-pfepyvaw 8 1 A a DT cord-011302-pfepyvaw 8 2 critical critical JJ cord-011302-pfepyvaw 8 3 part part NN cord-011302-pfepyvaw 8 4 of of IN cord-011302-pfepyvaw 8 5 assessing assess VBG cord-011302-pfepyvaw 8 6 appropriateness appropriateness NN cord-011302-pfepyvaw 8 7 for for IN cord-011302-pfepyvaw 8 8 surgical surgical JJ cord-011302-pfepyvaw 8 9 intervention intervention NN cord-011302-pfepyvaw 8 10 in in IN cord-011302-pfepyvaw 8 11 older old JJR cord-011302-pfepyvaw 8 12 patients patient NNS cord-011302-pfepyvaw 8 13 may may MD cord-011302-pfepyvaw 8 14 be be VB cord-011302-pfepyvaw 8 15 to to TO cord-011302-pfepyvaw 8 16 change change VB cord-011302-pfepyvaw 8 17 from from IN cord-011302-pfepyvaw 8 18 a a DT cord-011302-pfepyvaw 8 19 mindset mindset NN cord-011302-pfepyvaw 8 20 of of IN cord-011302-pfepyvaw 8 21 age age NN cord-011302-pfepyvaw 8 22 to to IN cord-011302-pfepyvaw 8 23 one one CD cord-011302-pfepyvaw 8 24 of of IN cord-011302-pfepyvaw 8 25 frailty frailty NN cord-011302-pfepyvaw 8 26 and and CC cord-011302-pfepyvaw 8 27 growing grow VBG cord-011302-pfepyvaw 8 28 interest interest NN cord-011302-pfepyvaw 8 29 in in IN cord-011302-pfepyvaw 8 30 scales scale NNS cord-011302-pfepyvaw 8 31 assessing assess VBG cord-011302-pfepyvaw 8 32 this this DT cord-011302-pfepyvaw 8 33 may may MD cord-011302-pfepyvaw 8 34 aid aid VB cord-011302-pfepyvaw 8 35 treatment treatment NN cord-011302-pfepyvaw 8 36 decisions decision NNS cord-011302-pfepyvaw 8 37 in in IN cord-011302-pfepyvaw 8 38 the the DT cord-011302-pfepyvaw 8 39 future future NN cord-011302-pfepyvaw 8 40 . . . cord-011302-pfepyvaw 9 1 Increased increase VBN cord-011302-pfepyvaw 9 2 life life NN cord-011302-pfepyvaw 9 3 expectancy expectancy NN cord-011302-pfepyvaw 9 4 , , , cord-011302-pfepyvaw 9 5 lower low JJR cord-011302-pfepyvaw 9 6 operative operative JJ cord-011302-pfepyvaw 9 7 morbidities morbidity NNS cord-011302-pfepyvaw 9 8 , , , cord-011302-pfepyvaw 9 9 and and CC cord-011302-pfepyvaw 9 10 enhanced enhanced JJ cord-011302-pfepyvaw 9 11 expectations expectation NNS cord-011302-pfepyvaw 9 12 from from IN cord-011302-pfepyvaw 9 13 patients patient NNS cord-011302-pfepyvaw 9 14 and and CC cord-011302-pfepyvaw 9 15 their -PRON- PRP$ cord-011302-pfepyvaw 9 16 families family NNS cord-011302-pfepyvaw 9 17 has have VBZ cord-011302-pfepyvaw 9 18 led lead VBN cord-011302-pfepyvaw 9 19 to to IN cord-011302-pfepyvaw 9 20 an an DT cord-011302-pfepyvaw 9 21 increasing increase VBG cord-011302-pfepyvaw 9 22 population population NN cord-011302-pfepyvaw 9 23 of of IN cord-011302-pfepyvaw 9 24 older old JJR cord-011302-pfepyvaw 9 25 patients patient NNS cord-011302-pfepyvaw 9 26 with with IN cord-011302-pfepyvaw 9 27 pathology pathology NN cord-011302-pfepyvaw 9 28 that that WDT cord-011302-pfepyvaw 9 29 may may MD cord-011302-pfepyvaw 9 30 be be VB cord-011302-pfepyvaw 9 31 amenable amenable JJ cord-011302-pfepyvaw 9 32 to to IN cord-011302-pfepyvaw 9 33 neurosurgical neurosurgical JJ cord-011302-pfepyvaw 9 34 treatment treatment NN cord-011302-pfepyvaw 9 35 . . . cord-011302-pfepyvaw 10 1 In in IN cord-011302-pfepyvaw 10 2 2010 2010 CD cord-011302-pfepyvaw 10 3 , , , cord-011302-pfepyvaw 10 4 Chibbaro Chibbaro NNP cord-011302-pfepyvaw 10 5 showed show VBD cord-011302-pfepyvaw 10 6 that that IN cord-011302-pfepyvaw 10 7 the the DT cord-011302-pfepyvaw 10 8 proportion proportion NN cord-011302-pfepyvaw 10 9 of of IN cord-011302-pfepyvaw 10 10 patients patient NNS cord-011302-pfepyvaw 10 11 aged age VBN cord-011302-pfepyvaw 10 12 70 70 CD cord-011302-pfepyvaw 10 13 and and CC cord-011302-pfepyvaw 10 14 over over IN cord-011302-pfepyvaw 10 15 admitted admit VBN cord-011302-pfepyvaw 10 16 to to IN cord-011302-pfepyvaw 10 17 a a DT cord-011302-pfepyvaw 10 18 Parisian parisian JJ cord-011302-pfepyvaw 10 19 neurosurgical neurosurgical JJ cord-011302-pfepyvaw 10 20 unit unit NN cord-011302-pfepyvaw 10 21 increased increase VBD cord-011302-pfepyvaw 10 22 from from IN cord-011302-pfepyvaw 10 23 11 11 CD cord-011302-pfepyvaw 10 24 % % NN cord-011302-pfepyvaw 10 25 in in IN cord-011302-pfepyvaw 10 26 1983 1983 CD cord-011302-pfepyvaw 10 27 to to IN cord-011302-pfepyvaw 10 28 25 25 CD cord-011302-pfepyvaw 10 29 % % NN cord-011302-pfepyvaw 10 30 in in IN cord-011302-pfepyvaw 10 31 2007 2007 CD cord-011302-pfepyvaw 10 32 [ [ -LRB- cord-011302-pfepyvaw 10 33 6 6 CD cord-011302-pfepyvaw 10 34 ] ] -RRB- cord-011302-pfepyvaw 10 35 . . . cord-011302-pfepyvaw 11 1 Surgical surgical JJ cord-011302-pfepyvaw 11 2 interventions intervention NNS cord-011302-pfepyvaw 11 3 also also RB cord-011302-pfepyvaw 11 4 increased increase VBD cord-011302-pfepyvaw 11 5 from from IN cord-011302-pfepyvaw 11 6 77 77 CD cord-011302-pfepyvaw 11 7 % % NN cord-011302-pfepyvaw 11 8 to to IN cord-011302-pfepyvaw 11 9 93 93 CD cord-011302-pfepyvaw 11 10 % % NN cord-011302-pfepyvaw 11 11 in in IN cord-011302-pfepyvaw 11 12 this this DT cord-011302-pfepyvaw 11 13 group group NN cord-011302-pfepyvaw 11 14 , , , cord-011302-pfepyvaw 11 15 with with IN cord-011302-pfepyvaw 11 16 a a DT cord-011302-pfepyvaw 11 17 particular particular JJ cord-011302-pfepyvaw 11 18 rise rise NN cord-011302-pfepyvaw 11 19 in in IN cord-011302-pfepyvaw 11 20 brain brain NN cord-011302-pfepyvaw 11 21 tumour tumour NN cord-011302-pfepyvaw 11 22 surgery surgery NN cord-011302-pfepyvaw 11 23 . . . cord-011302-pfepyvaw 12 1 Such such JJ cord-011302-pfepyvaw 12 2 trends trend NNS cord-011302-pfepyvaw 12 3 are be VBP cord-011302-pfepyvaw 12 4 set set VBN cord-011302-pfepyvaw 12 5 to to TO cord-011302-pfepyvaw 12 6 continue continue VB cord-011302-pfepyvaw 12 7 and and CC cord-011302-pfepyvaw 12 8 a a DT cord-011302-pfepyvaw 12 9 recent recent JJ cord-011302-pfepyvaw 12 10 report report NN cord-011302-pfepyvaw 12 11 from from IN cord-011302-pfepyvaw 12 12 a a DT cord-011302-pfepyvaw 12 13 UK UK NNP cord-011302-pfepyvaw 12 14 regional regional JJ cord-011302-pfepyvaw 12 15 neurosurgical neurosurgical JJ cord-011302-pfepyvaw 12 16 centre centre NN cord-011302-pfepyvaw 12 17 showed show VBD cord-011302-pfepyvaw 12 18 continued continued JJ cord-011302-pfepyvaw 12 19 increases increase NNS cord-011302-pfepyvaw 12 20 in in IN cord-011302-pfepyvaw 12 21 elderly elderly JJ cord-011302-pfepyvaw 12 22 admissions admission NNS cord-011302-pfepyvaw 12 23 from from IN cord-011302-pfepyvaw 12 24 2000 2000 CD cord-011302-pfepyvaw 12 25 to to IN cord-011302-pfepyvaw 12 26 2013 2013 CD cord-011302-pfepyvaw 12 27 , , , cord-011302-pfepyvaw 12 28 particularly particularly RB cord-011302-pfepyvaw 12 29 in in IN cord-011302-pfepyvaw 12 30 emergency emergency NN cord-011302-pfepyvaw 12 31 conditions condition NNS cord-011302-pfepyvaw 12 32 such such JJ cord-011302-pfepyvaw 12 33 as as IN cord-011302-pfepyvaw 12 34 traumatic traumatic JJ cord-011302-pfepyvaw 12 35 head head NN cord-011302-pfepyvaw 12 36 injury injury NN cord-011302-pfepyvaw 12 37 and and CC cord-011302-pfepyvaw 12 38 spontaneous spontaneous JJ cord-011302-pfepyvaw 12 39 subarachnoid subarachnoid NN cord-011302-pfepyvaw 12 40 haemorrhage haemorrhage NN cord-011302-pfepyvaw 12 41 [ [ -LRB- cord-011302-pfepyvaw 12 42 42 42 CD cord-011302-pfepyvaw 12 43 ] ] -RRB- cord-011302-pfepyvaw 12 44 . . . cord-011302-pfepyvaw 13 1 An an DT cord-011302-pfepyvaw 13 2 important important JJ cord-011302-pfepyvaw 13 3 driver driver NN cord-011302-pfepyvaw 13 4 of of IN cord-011302-pfepyvaw 13 5 increased increase VBN cord-011302-pfepyvaw 13 6 admissions admission NNS cord-011302-pfepyvaw 13 7 is be VBZ cord-011302-pfepyvaw 13 8 the the DT cord-011302-pfepyvaw 13 9 perceived perceive VBN cord-011302-pfepyvaw 13 10 improvement improvement NN cord-011302-pfepyvaw 13 11 in in IN cord-011302-pfepyvaw 13 12 outcomes outcome NNS cord-011302-pfepyvaw 13 13 in in IN cord-011302-pfepyvaw 13 14 older old JJR cord-011302-pfepyvaw 13 15 patients patient NNS cord-011302-pfepyvaw 13 16 . . . cord-011302-pfepyvaw 14 1 Chibbaro Chibbaro NNP cord-011302-pfepyvaw 14 2 showed show VBD cord-011302-pfepyvaw 14 3 a a DT cord-011302-pfepyvaw 14 4 dramatic dramatic JJ cord-011302-pfepyvaw 14 5 drop drop NN cord-011302-pfepyvaw 14 6 in in IN cord-011302-pfepyvaw 14 7 the the DT cord-011302-pfepyvaw 14 8 immediate immediate JJ cord-011302-pfepyvaw 14 9 mortality mortality NN cord-011302-pfepyvaw 14 10 rate rate NN cord-011302-pfepyvaw 14 11 , , , cord-011302-pfepyvaw 14 12 from from IN cord-011302-pfepyvaw 14 13 12 12 CD cord-011302-pfepyvaw 14 14 to to TO cord-011302-pfepyvaw 14 15 0.3 0.3 CD cord-011302-pfepyvaw 14 16 % % NN cord-011302-pfepyvaw 14 17 in in IN cord-011302-pfepyvaw 14 18 older old JJR cord-011302-pfepyvaw 14 19 patients patient NNS cord-011302-pfepyvaw 14 20 [ [ -LRB- cord-011302-pfepyvaw 14 21 6 6 CD cord-011302-pfepyvaw 14 22 ] ] -RRB- cord-011302-pfepyvaw 14 23 . . . cord-011302-pfepyvaw 15 1 Shifting shift VBG cord-011302-pfepyvaw 15 2 treatment treatment NN cord-011302-pfepyvaw 15 3 algorithms algorithm NNS cord-011302-pfepyvaw 15 4 , , , cord-011302-pfepyvaw 15 5 such such JJ cord-011302-pfepyvaw 15 6 as as IN cord-011302-pfepyvaw 15 7 endovascular endovascular JJ cord-011302-pfepyvaw 15 8 coiling coiling NN cord-011302-pfepyvaw 15 9 rather rather RB cord-011302-pfepyvaw 15 10 than than IN cord-011302-pfepyvaw 15 11 aneurysm aneurysm NN cord-011302-pfepyvaw 15 12 clipping clipping NN cord-011302-pfepyvaw 15 13 , , , cord-011302-pfepyvaw 15 14 account account NN cord-011302-pfepyvaw 15 15 , , , cord-011302-pfepyvaw 15 16 in in IN cord-011302-pfepyvaw 15 17 part part NN cord-011302-pfepyvaw 15 18 , , , cord-011302-pfepyvaw 15 19 for for IN cord-011302-pfepyvaw 15 20 improved improved JJ cord-011302-pfepyvaw 15 21 outcomes outcome NNS cord-011302-pfepyvaw 15 22 . . . cord-011302-pfepyvaw 16 1 However however RB cord-011302-pfepyvaw 16 2 , , , cord-011302-pfepyvaw 16 3 poor poor JJ cord-011302-pfepyvaw 16 4 outcomes outcome NNS cord-011302-pfepyvaw 16 5 still still RB cord-011302-pfepyvaw 16 6 prevail prevail VBP cord-011302-pfepyvaw 16 7 in in IN cord-011302-pfepyvaw 16 8 older old JJR cord-011302-pfepyvaw 16 9 patients patient NNS cord-011302-pfepyvaw 16 10 with with IN cord-011302-pfepyvaw 16 11 emergency emergency NN cord-011302-pfepyvaw 16 12 presentations presentation NNS cord-011302-pfepyvaw 16 13 : : : cord-011302-pfepyvaw 16 14 Whitehouse Whitehouse NNP cord-011302-pfepyvaw 16 15 reported report VBD cord-011302-pfepyvaw 16 16 5-year 5-year CD cord-011302-pfepyvaw 16 17 mortality mortality NN cord-011302-pfepyvaw 16 18 of of IN cord-011302-pfepyvaw 16 19 around around IN cord-011302-pfepyvaw 16 20 55 55 CD cord-011302-pfepyvaw 16 21 % % NN cord-011302-pfepyvaw 16 22 in in IN cord-011302-pfepyvaw 16 23 neurosurgical neurosurgical JJ cord-011302-pfepyvaw 16 24 patients patient NNS cord-011302-pfepyvaw 16 25 over over IN cord-011302-pfepyvaw 16 26 65 65 CD cord-011302-pfepyvaw 16 27 admitted admit VBD cord-011302-pfepyvaw 16 28 as as IN cord-011302-pfepyvaw 16 29 an an DT cord-011302-pfepyvaw 16 30 emergency emergency NN cord-011302-pfepyvaw 16 31 compared compare VBN cord-011302-pfepyvaw 16 32 with with IN cord-011302-pfepyvaw 16 33 less less JJR cord-011302-pfepyvaw 16 34 than than IN cord-011302-pfepyvaw 16 35 20 20 CD cord-011302-pfepyvaw 16 36 % % NN cord-011302-pfepyvaw 16 37 in in IN cord-011302-pfepyvaw 16 38 elective elective JJ cord-011302-pfepyvaw 16 39 patients patient NNS cord-011302-pfepyvaw 16 40 [ [ -LRB- cord-011302-pfepyvaw 16 41 42 42 CD cord-011302-pfepyvaw 16 42 ] ] -RRB- cord-011302-pfepyvaw 16 43 . . . cord-011302-pfepyvaw 17 1 Mortality mortality NN cord-011302-pfepyvaw 17 2 is be VBZ cord-011302-pfepyvaw 17 3 particularly particularly RB cord-011302-pfepyvaw 17 4 increased increase VBN cord-011302-pfepyvaw 17 5 within within IN cord-011302-pfepyvaw 17 6 6 6 CD cord-011302-pfepyvaw 17 7 months month NNS cord-011302-pfepyvaw 17 8 of of IN cord-011302-pfepyvaw 17 9 neurosurgical neurosurgical JJ cord-011302-pfepyvaw 17 10 treatment treatment NN cord-011302-pfepyvaw 17 11 and and CC cord-011302-pfepyvaw 17 12 , , , cord-011302-pfepyvaw 17 13 therefore therefore RB cord-011302-pfepyvaw 17 14 , , , cord-011302-pfepyvaw 17 15 surgical surgical JJ cord-011302-pfepyvaw 17 16 approaches approach NNS cord-011302-pfepyvaw 17 17 and and CC cord-011302-pfepyvaw 17 18 their -PRON- PRP$ cord-011302-pfepyvaw 17 19 associated associate VBN cord-011302-pfepyvaw 17 20 complications complication NNS cord-011302-pfepyvaw 17 21 need need VBP cord-011302-pfepyvaw 17 22 to to TO cord-011302-pfepyvaw 17 23 be be VB cord-011302-pfepyvaw 17 24 carefully carefully RB cord-011302-pfepyvaw 17 25 considered consider VBN cord-011302-pfepyvaw 17 26 to to TO cord-011302-pfepyvaw 17 27 improve improve VB cord-011302-pfepyvaw 17 28 outcomes outcome NNS cord-011302-pfepyvaw 17 29 . . . cord-011302-pfepyvaw 18 1 In in IN cord-011302-pfepyvaw 18 2 this this DT cord-011302-pfepyvaw 18 3 review review NN cord-011302-pfepyvaw 18 4 , , , cord-011302-pfepyvaw 18 5 we -PRON- PRP cord-011302-pfepyvaw 18 6 consider consider VBP cord-011302-pfepyvaw 18 7 changes change NNS cord-011302-pfepyvaw 18 8 in in IN cord-011302-pfepyvaw 18 9 practice practice NN cord-011302-pfepyvaw 18 10 and and CC cord-011302-pfepyvaw 18 11 current current JJ cord-011302-pfepyvaw 18 12 treatment treatment NN cord-011302-pfepyvaw 18 13 outcomes outcome NNS cord-011302-pfepyvaw 18 14 in in IN cord-011302-pfepyvaw 18 15 older old JJR cord-011302-pfepyvaw 18 16 patients patient NNS cord-011302-pfepyvaw 18 17 with with IN cord-011302-pfepyvaw 18 18 aneurysmal aneurysmal NNP cord-011302-pfepyvaw 18 19 subarachnoid subarachnoid NN cord-011302-pfepyvaw 18 20 haemorrhage haemorrhage NN cord-011302-pfepyvaw 18 21 , , , cord-011302-pfepyvaw 18 22 traumatic traumatic JJ cord-011302-pfepyvaw 18 23 head head NN cord-011302-pfepyvaw 18 24 injury injury NN cord-011302-pfepyvaw 18 25 , , , cord-011302-pfepyvaw 18 26 and and CC cord-011302-pfepyvaw 18 27 haemorrhagic haemorrhagic JJ cord-011302-pfepyvaw 18 28 strokes stroke NNS cord-011302-pfepyvaw 18 29 . . . cord-011302-pfepyvaw 19 1 We -PRON- PRP cord-011302-pfepyvaw 19 2 focus focus VBP cord-011302-pfepyvaw 19 3 on on IN cord-011302-pfepyvaw 19 4 the the DT cord-011302-pfepyvaw 19 5 assessment assessment NN cord-011302-pfepyvaw 19 6 of of IN cord-011302-pfepyvaw 19 7 frailty frailty NN cord-011302-pfepyvaw 19 8 in in IN cord-011302-pfepyvaw 19 9 older old JJR cord-011302-pfepyvaw 19 10 patients patient NNS cord-011302-pfepyvaw 19 11 and and CC cord-011302-pfepyvaw 19 12 how how WRB cord-011302-pfepyvaw 19 13 this this DT cord-011302-pfepyvaw 19 14 can can MD cord-011302-pfepyvaw 19 15 help help VB cord-011302-pfepyvaw 19 16 to to TO cord-011302-pfepyvaw 19 17 inform inform VB cord-011302-pfepyvaw 19 18 future future JJ cord-011302-pfepyvaw 19 19 treatment treatment NN cord-011302-pfepyvaw 19 20 planning planning NN cord-011302-pfepyvaw 19 21 . . . cord-011302-pfepyvaw 20 1 Incidental incidental JJ cord-011302-pfepyvaw 20 2 , , , cord-011302-pfepyvaw 20 3 unruptured unruptured JJ cord-011302-pfepyvaw 20 4 cerebral cerebral JJ cord-011302-pfepyvaw 20 5 aneurysms aneurysm NNS cord-011302-pfepyvaw 20 6 pose pose VBP cord-011302-pfepyvaw 20 7 a a DT cord-011302-pfepyvaw 20 8 risk risk NN cord-011302-pfepyvaw 20 9 of of IN cord-011302-pfepyvaw 20 10 rupture rupture NN cord-011302-pfepyvaw 20 11 over over IN cord-011302-pfepyvaw 20 12 time time NN cord-011302-pfepyvaw 20 13 ; ; : cord-011302-pfepyvaw 20 14 factors factor NNS cord-011302-pfepyvaw 20 15 including include VBG cord-011302-pfepyvaw 20 16 size size NN cord-011302-pfepyvaw 20 17 and and CC cord-011302-pfepyvaw 20 18 location location NN cord-011302-pfepyvaw 20 19 influence influence NN cord-011302-pfepyvaw 20 20 this this DT cord-011302-pfepyvaw 20 21 risk risk NN cord-011302-pfepyvaw 20 22 [ [ -LRB- cord-011302-pfepyvaw 20 23 43 43 CD cord-011302-pfepyvaw 20 24 ] ] -RRB- cord-011302-pfepyvaw 20 25 . . . cord-011302-pfepyvaw 21 1 It -PRON- PRP cord-011302-pfepyvaw 21 2 is be VBZ cord-011302-pfepyvaw 21 3 logical logical JJ cord-011302-pfepyvaw 21 4 , , , cord-011302-pfepyvaw 21 5 that that IN cord-011302-pfepyvaw 21 6 as as IN cord-011302-pfepyvaw 21 7 people people NNS cord-011302-pfepyvaw 21 8 live live VBP cord-011302-pfepyvaw 21 9 longer long RBR cord-011302-pfepyvaw 21 10 , , , cord-011302-pfepyvaw 21 11 there there EX cord-011302-pfepyvaw 21 12 is be VBZ cord-011302-pfepyvaw 21 13 a a DT cord-011302-pfepyvaw 21 14 greater great JJR cord-011302-pfepyvaw 21 15 lifetime lifetime NN cord-011302-pfepyvaw 21 16 risk risk NN cord-011302-pfepyvaw 21 17 of of IN cord-011302-pfepyvaw 21 18 incidental incidental JJ cord-011302-pfepyvaw 21 19 aneurysm aneurysm NN cord-011302-pfepyvaw 21 20 rupture rupture NN cord-011302-pfepyvaw 21 21 and and CC cord-011302-pfepyvaw 21 22 presentation presentation NN cord-011302-pfepyvaw 21 23 with with IN cord-011302-pfepyvaw 21 24 a a DT cord-011302-pfepyvaw 21 25 subarachnoid subarachnoid NN cord-011302-pfepyvaw 21 26 haemorrhage haemorrhage NN cord-011302-pfepyvaw 21 27 ( ( -LRB- cord-011302-pfepyvaw 21 28 SAH SAH NNP cord-011302-pfepyvaw 21 29 ) ) -RRB- cord-011302-pfepyvaw 21 30 . . . cord-011302-pfepyvaw 22 1 Conversely conversely RB cord-011302-pfepyvaw 22 2 , , , cord-011302-pfepyvaw 22 3 the the DT cord-011302-pfepyvaw 22 4 first first JJ cord-011302-pfepyvaw 22 5 detection detection NN cord-011302-pfepyvaw 22 6 of of IN cord-011302-pfepyvaw 22 7 an an DT cord-011302-pfepyvaw 22 8 incidental incidental JJ cord-011302-pfepyvaw 22 9 cerebral cerebral JJ cord-011302-pfepyvaw 22 10 aneurysm aneurysm NN cord-011302-pfepyvaw 22 11 in in IN cord-011302-pfepyvaw 22 12 later later JJ cord-011302-pfepyvaw 22 13 life life NN cord-011302-pfepyvaw 22 14 means mean VBZ cord-011302-pfepyvaw 22 15 that that IN cord-011302-pfepyvaw 22 16 there there EX cord-011302-pfepyvaw 22 17 is be VBZ cord-011302-pfepyvaw 22 18 a a DT cord-011302-pfepyvaw 22 19 reduced reduce VBN cord-011302-pfepyvaw 22 20 effect effect NN cord-011302-pfepyvaw 22 21 of of IN cord-011302-pfepyvaw 22 22 any any DT cord-011302-pfepyvaw 22 23 preventative preventative JJ cord-011302-pfepyvaw 22 24 treatment treatment NN cord-011302-pfepyvaw 22 25 due due IN cord-011302-pfepyvaw 22 26 to to IN cord-011302-pfepyvaw 22 27 the the DT cord-011302-pfepyvaw 22 28 deceased deceased JJ cord-011302-pfepyvaw 22 29 remaining remain VBG cord-011302-pfepyvaw 22 30 life life NN cord-011302-pfepyvaw 22 31 expectancy expectancy NN cord-011302-pfepyvaw 22 32 in in IN cord-011302-pfepyvaw 22 33 the the DT cord-011302-pfepyvaw 22 34 elderly elderly JJ cord-011302-pfepyvaw 22 35 . . . cord-011302-pfepyvaw 23 1 In in IN cord-011302-pfepyvaw 23 2 addition addition NN cord-011302-pfepyvaw 23 3 , , , cord-011302-pfepyvaw 23 4 the the DT cord-011302-pfepyvaw 23 5 outcomes outcome NNS cord-011302-pfepyvaw 23 6 , , , cord-011302-pfepyvaw 23 7 in in IN cord-011302-pfepyvaw 23 8 terms term NNS cord-011302-pfepyvaw 23 9 of of IN cord-011302-pfepyvaw 23 10 quality quality NN cord-011302-pfepyvaw 23 11 of of IN cord-011302-pfepyvaw 23 12 life life NN cord-011302-pfepyvaw 23 13 and and CC cord-011302-pfepyvaw 23 14 mortality mortality NN cord-011302-pfepyvaw 23 15 , , , cord-011302-pfepyvaw 23 16 from from IN cord-011302-pfepyvaw 23 17 treated treat VBN cord-011302-pfepyvaw 23 18 aneurysmal aneurysmal NNP cord-011302-pfepyvaw 23 19 SAH SAH NNP cord-011302-pfepyvaw 23 20 in in IN cord-011302-pfepyvaw 23 21 older old JJR cord-011302-pfepyvaw 23 22 patients patient NNS cord-011302-pfepyvaw 23 23 are be VBP cord-011302-pfepyvaw 23 24 variable variable JJ cord-011302-pfepyvaw 23 25 . . . cord-011302-pfepyvaw 24 1 As as IN cord-011302-pfepyvaw 24 2 such such JJ cord-011302-pfepyvaw 24 3 , , , cord-011302-pfepyvaw 24 4 it -PRON- PRP cord-011302-pfepyvaw 24 5 is be VBZ cord-011302-pfepyvaw 24 6 important important JJ cord-011302-pfepyvaw 24 7 that that IN cord-011302-pfepyvaw 24 8 we -PRON- PRP cord-011302-pfepyvaw 24 9 have have VBP cord-011302-pfepyvaw 24 10 robust robust JJ cord-011302-pfepyvaw 24 11 data datum NNS cord-011302-pfepyvaw 24 12 on on IN cord-011302-pfepyvaw 24 13 all all PDT cord-011302-pfepyvaw 24 14 these these DT cord-011302-pfepyvaw 24 15 aspects aspect NNS cord-011302-pfepyvaw 24 16 , , , cord-011302-pfepyvaw 24 17 to to TO cord-011302-pfepyvaw 24 18 guide guide VB cord-011302-pfepyvaw 24 19 the the DT cord-011302-pfepyvaw 24 20 management management NN cord-011302-pfepyvaw 24 21 of of IN cord-011302-pfepyvaw 24 22 both both CC cord-011302-pfepyvaw 24 23 ruptured ruptured JJ cord-011302-pfepyvaw 24 24 and and CC cord-011302-pfepyvaw 24 25 unruptured unruptured JJ cord-011302-pfepyvaw 24 26 aneurysms aneurysm NNS cord-011302-pfepyvaw 24 27 in in IN cord-011302-pfepyvaw 24 28 the the DT cord-011302-pfepyvaw 24 29 older old JJR cord-011302-pfepyvaw 24 30 person person NN cord-011302-pfepyvaw 24 31 . . . cord-011302-pfepyvaw 25 1 In in IN cord-011302-pfepyvaw 25 2 2006 2006 CD cord-011302-pfepyvaw 25 3 , , , cord-011302-pfepyvaw 25 4 Nieuwkamp Nieuwkamp NNP cord-011302-pfepyvaw 25 5 et et NNP cord-011302-pfepyvaw 25 6 al al NNP cord-011302-pfepyvaw 25 7 . . NNP cord-011302-pfepyvaw 25 8 reported report VBD cord-011302-pfepyvaw 25 9 outcomes outcome NNS cord-011302-pfepyvaw 25 10 in in IN cord-011302-pfepyvaw 25 11 170 170 CD cord-011302-pfepyvaw 25 12 patients patient NNS cord-011302-pfepyvaw 25 13 aged age VBN cord-011302-pfepyvaw 25 14 ≥ ≥ CD cord-011302-pfepyvaw 25 15 75 75 CD cord-011302-pfepyvaw 25 16 years year NNS cord-011302-pfepyvaw 25 17 presenting present VBG cord-011302-pfepyvaw 25 18 with with IN cord-011302-pfepyvaw 25 19 aneurysmal aneurysmal NNP cord-011302-pfepyvaw 25 20 SAH SAH NNP cord-011302-pfepyvaw 25 21 , , , cord-011302-pfepyvaw 25 22 where where WRB cord-011302-pfepyvaw 25 23 only only RB cord-011302-pfepyvaw 25 24 20 20 CD cord-011302-pfepyvaw 25 25 % % NN cord-011302-pfepyvaw 25 26 of of IN cord-011302-pfepyvaw 25 27 patients patient NNS cord-011302-pfepyvaw 25 28 were be VBD cord-011302-pfepyvaw 25 29 clipped clip VBN cord-011302-pfepyvaw 25 30 and and CC cord-011302-pfepyvaw 25 31 8 8 CD cord-011302-pfepyvaw 25 32 % % NN cord-011302-pfepyvaw 25 33 coiled coil VBN cord-011302-pfepyvaw 25 34 [ [ -LRB- cord-011302-pfepyvaw 25 35 27 27 CD cord-011302-pfepyvaw 25 36 ] ] -RRB- cord-011302-pfepyvaw 25 37 . . . cord-011302-pfepyvaw 26 1 Overall overall RB cord-011302-pfepyvaw 26 2 , , , cord-011302-pfepyvaw 26 3 half half PDT cord-011302-pfepyvaw 26 4 the the DT cord-011302-pfepyvaw 26 5 patients patient NNS cord-011302-pfepyvaw 26 6 died die VBD cord-011302-pfepyvaw 26 7 and and CC cord-011302-pfepyvaw 26 8 only only RB cord-011302-pfepyvaw 26 9 one one CD cord-011302-pfepyvaw 26 10 in in IN cord-011302-pfepyvaw 26 11 six six CD cord-011302-pfepyvaw 26 12 returned return VBN cord-011302-pfepyvaw 26 13 to to IN cord-011302-pfepyvaw 26 14 independent independent JJ cord-011302-pfepyvaw 26 15 function function NN cord-011302-pfepyvaw 26 16 by by IN cord-011302-pfepyvaw 26 17 discharge discharge NN cord-011302-pfepyvaw 26 18 . . . cord-011302-pfepyvaw 27 1 Of of IN cord-011302-pfepyvaw 27 2 their -PRON- PRP$ cord-011302-pfepyvaw 27 3 60 60 CD cord-011302-pfepyvaw 27 4 patients patient NNS cord-011302-pfepyvaw 27 5 admitted admit VBN cord-011302-pfepyvaw 27 6 in in IN cord-011302-pfepyvaw 27 7 a a DT cord-011302-pfepyvaw 27 8 poor poor JJ cord-011302-pfepyvaw 27 9 condition condition NN cord-011302-pfepyvaw 27 10 ( ( -LRB- cord-011302-pfepyvaw 27 11 those those DT cord-011302-pfepyvaw 27 12 with with IN cord-011302-pfepyvaw 27 13 a a DT cord-011302-pfepyvaw 27 14 Glasgow Glasgow NNP cord-011302-pfepyvaw 27 15 Coma Coma NNP cord-011302-pfepyvaw 27 16 Score Score NNP cord-011302-pfepyvaw 27 17 of of IN cord-011302-pfepyvaw 27 18 12 12 CD cord-011302-pfepyvaw 27 19 or or CC cord-011302-pfepyvaw 27 20 less less JJR cord-011302-pfepyvaw 27 21 ) ) -RRB- cord-011302-pfepyvaw 27 22 , , , cord-011302-pfepyvaw 27 23 none none NN cord-011302-pfepyvaw 27 24 were be VBD cord-011302-pfepyvaw 27 25 independent independent JJ cord-011302-pfepyvaw 27 26 at at IN cord-011302-pfepyvaw 27 27 discharge discharge NN cord-011302-pfepyvaw 27 28 . . . cord-011302-pfepyvaw 28 1 The the DT cord-011302-pfepyvaw 28 2 strongest strong JJS cord-011302-pfepyvaw 28 3 predictor predictor NN cord-011302-pfepyvaw 28 4 of of IN cord-011302-pfepyvaw 28 5 poor poor JJ cord-011302-pfepyvaw 28 6 outcome outcome NN cord-011302-pfepyvaw 28 7 in in IN cord-011302-pfepyvaw 28 8 good good JJ cord-011302-pfepyvaw 28 9 - - HYPH cord-011302-pfepyvaw 28 10 grade grade NN cord-011302-pfepyvaw 28 11 admissions admission NNS cord-011302-pfepyvaw 28 12 was be VBD cord-011302-pfepyvaw 28 13 re re VBN cord-011302-pfepyvaw 28 14 - - NN cord-011302-pfepyvaw 28 15 bleeding bleeding JJ cord-011302-pfepyvaw 28 16 . . . cord-011302-pfepyvaw 29 1 Compared compare VBN cord-011302-pfepyvaw 29 2 to to IN cord-011302-pfepyvaw 29 3 younger young JJR cord-011302-pfepyvaw 29 4 SAH SAH NNP cord-011302-pfepyvaw 29 5 patients patient NNS cord-011302-pfepyvaw 29 6 , , , cord-011302-pfepyvaw 29 7 those those DT cord-011302-pfepyvaw 29 8 aged age VBN cord-011302-pfepyvaw 29 9 75 75 CD cord-011302-pfepyvaw 29 10 and and CC cord-011302-pfepyvaw 29 11 over over RB cord-011302-pfepyvaw 29 12 were be VBD cord-011302-pfepyvaw 29 13 more more RBR cord-011302-pfepyvaw 29 14 likely likely JJ cord-011302-pfepyvaw 29 15 to to TO cord-011302-pfepyvaw 29 16 be be VB cord-011302-pfepyvaw 29 17 female female JJ cord-011302-pfepyvaw 29 18 ( ( -LRB- cord-011302-pfepyvaw 29 19 perhaps perhaps RB cord-011302-pfepyvaw 29 20 due due IN cord-011302-pfepyvaw 29 21 to to IN cord-011302-pfepyvaw 29 22 greater great JJR cord-011302-pfepyvaw 29 23 life life NN cord-011302-pfepyvaw 29 24 expectancy expectancy NN cord-011302-pfepyvaw 29 25 ) ) -RRB- cord-011302-pfepyvaw 29 26 and and CC cord-011302-pfepyvaw 29 27 suffer suffer VB cord-011302-pfepyvaw 29 28 with with IN cord-011302-pfepyvaw 29 29 medical medical JJ cord-011302-pfepyvaw 29 30 complications complication NNS cord-011302-pfepyvaw 29 31 and and CC cord-011302-pfepyvaw 29 32 hydrocephalus hydrocephalus NN cord-011302-pfepyvaw 29 33 . . . cord-011302-pfepyvaw 30 1 The the DT cord-011302-pfepyvaw 30 2 authors author NNS cord-011302-pfepyvaw 30 3 suggested suggest VBD cord-011302-pfepyvaw 30 4 that that IN cord-011302-pfepyvaw 30 5 the the DT cord-011302-pfepyvaw 30 6 early early JJ cord-011302-pfepyvaw 30 7 treatment treatment NN cord-011302-pfepyvaw 30 8 of of IN cord-011302-pfepyvaw 30 9 patients patient NNS cord-011302-pfepyvaw 30 10 in in IN cord-011302-pfepyvaw 30 11 a a DT cord-011302-pfepyvaw 30 12 good good JJ cord-011302-pfepyvaw 30 13 condition condition NN cord-011302-pfepyvaw 30 14 may may MD cord-011302-pfepyvaw 30 15 prevent prevent VB cord-011302-pfepyvaw 30 16 re re NN cord-011302-pfepyvaw 30 17 - - NN cord-011302-pfepyvaw 30 18 bleeding bleeding JJ cord-011302-pfepyvaw 30 19 and and CC cord-011302-pfepyvaw 30 20 thus thus RB cord-011302-pfepyvaw 30 21 improve improve VB cord-011302-pfepyvaw 30 22 outcomes outcome NNS cord-011302-pfepyvaw 30 23 . . . cord-011302-pfepyvaw 31 1 In in IN cord-011302-pfepyvaw 31 2 2013 2013 CD cord-011302-pfepyvaw 31 3 , , , cord-011302-pfepyvaw 31 4 Scholler Scholler NNP cord-011302-pfepyvaw 31 5 analysed analyse VBD cord-011302-pfepyvaw 31 6 265 265 CD cord-011302-pfepyvaw 31 7 patients patient NNS cord-011302-pfepyvaw 31 8 over over IN cord-011302-pfepyvaw 31 9 the the DT cord-011302-pfepyvaw 31 10 age age NN cord-011302-pfepyvaw 31 11 of of IN cord-011302-pfepyvaw 31 12 60 60 CD cord-011302-pfepyvaw 31 13 with with IN cord-011302-pfepyvaw 31 14 aneurysmal aneurysmal NNP cord-011302-pfepyvaw 31 15 SAH SAH NNP cord-011302-pfepyvaw 31 16 , , , cord-011302-pfepyvaw 31 17 with with IN cord-011302-pfepyvaw 31 18 36 36 CD cord-011302-pfepyvaw 31 19 % % NN cord-011302-pfepyvaw 31 20 aged age VBN cord-011302-pfepyvaw 31 21 between between IN cord-011302-pfepyvaw 31 22 70 70 CD cord-011302-pfepyvaw 31 23 and and CC cord-011302-pfepyvaw 31 24 79 79 CD cord-011302-pfepyvaw 31 25 and and CC cord-011302-pfepyvaw 31 26 only only RB cord-011302-pfepyvaw 31 27 10 10 CD cord-011302-pfepyvaw 31 28 % % NN cord-011302-pfepyvaw 31 29 over over IN cord-011302-pfepyvaw 31 30 80 80 CD cord-011302-pfepyvaw 31 31 [ [ -LRB- cord-011302-pfepyvaw 31 32 33 33 CD cord-011302-pfepyvaw 31 33 ] ] -RRB- cord-011302-pfepyvaw 31 34 . . . cord-011302-pfepyvaw 32 1 Challenges challenge NNS cord-011302-pfepyvaw 32 2 identified identify VBN cord-011302-pfepyvaw 32 3 in in IN cord-011302-pfepyvaw 32 4 this this DT cord-011302-pfepyvaw 32 5 older old JJR cord-011302-pfepyvaw 32 6 population population NN cord-011302-pfepyvaw 32 7 included include VBD cord-011302-pfepyvaw 32 8 increased increase VBN cord-011302-pfepyvaw 32 9 co co NNS cord-011302-pfepyvaw 32 10 - - NNS cord-011302-pfepyvaw 32 11 morbidities morbidity NNS cord-011302-pfepyvaw 32 12 ( ( -LRB- cord-011302-pfepyvaw 32 13 92 92 CD cord-011302-pfepyvaw 32 14 % % NN cord-011302-pfepyvaw 32 15 had have VBD cord-011302-pfepyvaw 32 16 at at RB cord-011302-pfepyvaw 32 17 least least JJS cord-011302-pfepyvaw 32 18 one one CD cord-011302-pfepyvaw 32 19 ) ) -RRB- cord-011302-pfepyvaw 32 20 , , , cord-011302-pfepyvaw 32 21 the the DT cord-011302-pfepyvaw 32 22 use use NN cord-011302-pfepyvaw 32 23 of of IN cord-011302-pfepyvaw 32 24 anti anti JJ cord-011302-pfepyvaw 32 25 - - JJ cord-011302-pfepyvaw 32 26 thrombotic thrombotic JJ cord-011302-pfepyvaw 32 27 drugs drug NNS cord-011302-pfepyvaw 32 28 ( ( -LRB- cord-011302-pfepyvaw 32 29 in in IN cord-011302-pfepyvaw 32 30 29 29 CD cord-011302-pfepyvaw 32 31 % % NN cord-011302-pfepyvaw 32 32 ) ) -RRB- cord-011302-pfepyvaw 32 33 and and CC cord-011302-pfepyvaw 32 34 increased increase VBN cord-011302-pfepyvaw 32 35 prevalence prevalence NN cord-011302-pfepyvaw 32 36 of of IN cord-011302-pfepyvaw 32 37 hydrocephalus hydrocephalus NN cord-011302-pfepyvaw 32 38 requiring require VBG cord-011302-pfepyvaw 32 39 an an DT cord-011302-pfepyvaw 32 40 EVD evd NN cord-011302-pfepyvaw 32 41 in in IN cord-011302-pfepyvaw 32 42 those those DT cord-011302-pfepyvaw 32 43 aged age VBN cord-011302-pfepyvaw 32 44 70 70 CD cord-011302-pfepyvaw 32 45 - - SYM cord-011302-pfepyvaw 32 46 80 80 CD cord-011302-pfepyvaw 32 47 years year NNS cord-011302-pfepyvaw 32 48 ( ( -LRB- cord-011302-pfepyvaw 32 49 77 77 CD cord-011302-pfepyvaw 32 50 % % NN cord-011302-pfepyvaw 32 51 ) ) -RRB- cord-011302-pfepyvaw 32 52 compared compare VBN cord-011302-pfepyvaw 32 53 to to IN cord-011302-pfepyvaw 32 54 60 60 CD cord-011302-pfepyvaw 32 55 - - HYPH cord-011302-pfepyvaw 32 56 70-year 70-year JJ cord-011302-pfepyvaw 32 57 - - HYPH cord-011302-pfepyvaw 32 58 olds old NNS cord-011302-pfepyvaw 32 59 ( ( -LRB- cord-011302-pfepyvaw 32 60 61 61 CD cord-011302-pfepyvaw 32 61 % % NN cord-011302-pfepyvaw 32 62 ) ) -RRB- cord-011302-pfepyvaw 32 63 . . . cord-011302-pfepyvaw 33 1 Interventional interventional JJ cord-011302-pfepyvaw 33 2 treatment treatment NN cord-011302-pfepyvaw 33 3 was be VBD cord-011302-pfepyvaw 33 4 undertaken undertake VBN cord-011302-pfepyvaw 33 5 in in IN cord-011302-pfepyvaw 33 6 85 85 CD cord-011302-pfepyvaw 33 7 % % NN cord-011302-pfepyvaw 33 8 of of IN cord-011302-pfepyvaw 33 9 cases case NNS cord-011302-pfepyvaw 33 10 , , , cord-011302-pfepyvaw 33 11 with with IN cord-011302-pfepyvaw 33 12 clipping clip VBG cord-011302-pfepyvaw 33 13 in in IN cord-011302-pfepyvaw 33 14 48 48 CD cord-011302-pfepyvaw 33 15 % % NN cord-011302-pfepyvaw 33 16 and and CC cord-011302-pfepyvaw 33 17 coiling coil VBG cord-011302-pfepyvaw 33 18 in in IN cord-011302-pfepyvaw 33 19 37 37 CD cord-011302-pfepyvaw 33 20 % % NN cord-011302-pfepyvaw 33 21 , , , cord-011302-pfepyvaw 33 22 the the DT cord-011302-pfepyvaw 33 23 latter latter JJ cord-011302-pfepyvaw 33 24 more more RBR cord-011302-pfepyvaw 33 25 commonly commonly RB cord-011302-pfepyvaw 33 26 in in IN cord-011302-pfepyvaw 33 27 those those DT cord-011302-pfepyvaw 33 28 aged age VBN cord-011302-pfepyvaw 33 29 over over IN cord-011302-pfepyvaw 33 30 80 80 CD cord-011302-pfepyvaw 33 31 . . . cord-011302-pfepyvaw 34 1 Outcome outcome NN cord-011302-pfepyvaw 34 2 was be VBD cord-011302-pfepyvaw 34 3 clearly clearly RB cord-011302-pfepyvaw 34 4 associated associate VBN cord-011302-pfepyvaw 34 5 with with IN cord-011302-pfepyvaw 34 6 age age NN cord-011302-pfepyvaw 34 7 ; ; : cord-011302-pfepyvaw 34 8 death death NN cord-011302-pfepyvaw 34 9 or or CC cord-011302-pfepyvaw 34 10 poor poor JJ cord-011302-pfepyvaw 34 11 outcome outcome NN cord-011302-pfepyvaw 34 12 at at IN cord-011302-pfepyvaw 34 13 discharge discharge NN cord-011302-pfepyvaw 34 14 occurred occur VBD cord-011302-pfepyvaw 34 15 in in IN cord-011302-pfepyvaw 34 16 73 73 CD cord-011302-pfepyvaw 34 17 % % NN cord-011302-pfepyvaw 34 18 of of IN cord-011302-pfepyvaw 34 19 over over IN cord-011302-pfepyvaw 34 20 70 70 CD cord-011302-pfepyvaw 34 21 years year NNS cord-011302-pfepyvaw 34 22 old old JJ cord-011302-pfepyvaw 34 23 compared compare VBN cord-011302-pfepyvaw 34 24 with with IN cord-011302-pfepyvaw 34 25 51 51 CD cord-011302-pfepyvaw 34 26 % % NN cord-011302-pfepyvaw 34 27 of of IN cord-011302-pfepyvaw 34 28 60 60 CD cord-011302-pfepyvaw 34 29 - - SYM cord-011302-pfepyvaw 34 30 70 70 CD cord-011302-pfepyvaw 34 31 years year NNS cord-011302-pfepyvaw 34 32 old old JJ cord-011302-pfepyvaw 34 33 . . . cord-011302-pfepyvaw 35 1 Condition condition NN cord-011302-pfepyvaw 35 2 at at IN cord-011302-pfepyvaw 35 3 presentation presentation NN cord-011302-pfepyvaw 35 4 was be VBD cord-011302-pfepyvaw 35 5 also also RB cord-011302-pfepyvaw 35 6 important important JJ cord-011302-pfepyvaw 35 7 with with IN cord-011302-pfepyvaw 35 8 no no DT cord-011302-pfepyvaw 35 9 poor poor JJ cord-011302-pfepyvaw 35 10 grade grade NN cord-011302-pfepyvaw 35 11 at at IN cord-011302-pfepyvaw 35 12 presentation presentation NN cord-011302-pfepyvaw 35 13 patients patient NNS cord-011302-pfepyvaw 35 14 ( ( -LRB- cord-011302-pfepyvaw 35 15 WFNS WFNS NNP cord-011302-pfepyvaw 35 16 4 4 CD cord-011302-pfepyvaw 35 17 - - SYM cord-011302-pfepyvaw 35 18 5 5 CD cord-011302-pfepyvaw 35 19 ) ) -RRB- cord-011302-pfepyvaw 35 20 aged age VBN cord-011302-pfepyvaw 35 21 over over IN cord-011302-pfepyvaw 35 22 80 80 CD cord-011302-pfepyvaw 35 23 experiencing experience VBG cord-011302-pfepyvaw 35 24 a a DT cord-011302-pfepyvaw 35 25 good good JJ cord-011302-pfepyvaw 35 26 outcome outcome NN cord-011302-pfepyvaw 35 27 at at IN cord-011302-pfepyvaw 35 28 discharge discharge NN cord-011302-pfepyvaw 35 29 . . . cord-011302-pfepyvaw 36 1 It -PRON- PRP cord-011302-pfepyvaw 36 2 is be VBZ cord-011302-pfepyvaw 36 3 important important JJ cord-011302-pfepyvaw 36 4 to to TO cord-011302-pfepyvaw 36 5 note note VB cord-011302-pfepyvaw 36 6 that that IN cord-011302-pfepyvaw 36 7 although although IN cord-011302-pfepyvaw 36 8 70 70 CD cord-011302-pfepyvaw 36 9 % % NN cord-011302-pfepyvaw 36 10 of of IN cord-011302-pfepyvaw 36 11 conservatively conservatively RB cord-011302-pfepyvaw 36 12 managed manage VBN cord-011302-pfepyvaw 36 13 patients patient NNS cord-011302-pfepyvaw 36 14 died die VBD cord-011302-pfepyvaw 36 15 , , , cord-011302-pfepyvaw 36 16 none none NN cord-011302-pfepyvaw 36 17 were be VBD cord-011302-pfepyvaw 36 18 due due JJ cord-011302-pfepyvaw 36 19 to to IN cord-011302-pfepyvaw 36 20 re re VB cord-011302-pfepyvaw 36 21 - - VB cord-011302-pfepyvaw 36 22 bleed bleed VB cord-011302-pfepyvaw 36 23 , , , cord-011302-pfepyvaw 36 24 suggesting suggest VBG cord-011302-pfepyvaw 36 25 that that IN cord-011302-pfepyvaw 36 26 it -PRON- PRP cord-011302-pfepyvaw 36 27 is be VBZ cord-011302-pfepyvaw 36 28 the the DT cord-011302-pfepyvaw 36 29 nature nature NN cord-011302-pfepyvaw 36 30 of of IN cord-011302-pfepyvaw 36 31 the the DT cord-011302-pfepyvaw 36 32 initial initial JJ cord-011302-pfepyvaw 36 33 bleed bleed NN cord-011302-pfepyvaw 36 34 and and CC cord-011302-pfepyvaw 36 35 not not RB cord-011302-pfepyvaw 36 36 any any DT cord-011302-pfepyvaw 36 37 failure failure NN cord-011302-pfepyvaw 36 38 to to TO cord-011302-pfepyvaw 36 39 treat treat VB cord-011302-pfepyvaw 36 40 , , , cord-011302-pfepyvaw 36 41 that that IN cord-011302-pfepyvaw 36 42 results result VBZ cord-011302-pfepyvaw 36 43 in in IN cord-011302-pfepyvaw 36 44 the the DT cord-011302-pfepyvaw 36 45 poor poor JJ cord-011302-pfepyvaw 36 46 outcome outcome NN cord-011302-pfepyvaw 36 47 . . . cord-011302-pfepyvaw 37 1 There there EX cord-011302-pfepyvaw 37 2 has have VBZ cord-011302-pfepyvaw 37 3 also also RB cord-011302-pfepyvaw 37 4 been be VBN cord-011302-pfepyvaw 37 5 a a DT cord-011302-pfepyvaw 37 6 significant significant JJ cord-011302-pfepyvaw 37 7 shift shift NN cord-011302-pfepyvaw 37 8 in in IN cord-011302-pfepyvaw 37 9 practice practice NN cord-011302-pfepyvaw 37 10 in in IN cord-011302-pfepyvaw 37 11 the the DT cord-011302-pfepyvaw 37 12 last last JJ cord-011302-pfepyvaw 37 13 15 15 CD cord-011302-pfepyvaw 37 14 years year NNS cord-011302-pfepyvaw 37 15 towards towards IN cord-011302-pfepyvaw 37 16 coiling coil VBG cord-011302-pfepyvaw 37 17 , , , cord-011302-pfepyvaw 37 18 rather rather RB cord-011302-pfepyvaw 37 19 than than IN cord-011302-pfepyvaw 37 20 clipping clip VBG cord-011302-pfepyvaw 37 21 since since IN cord-011302-pfepyvaw 37 22 the the DT cord-011302-pfepyvaw 37 23 International International NNP cord-011302-pfepyvaw 37 24 Subarachnoid Subarachnoid NNP cord-011302-pfepyvaw 37 25 Aneurysm Aneurysm NNP cord-011302-pfepyvaw 37 26 Trial Trial NNP cord-011302-pfepyvaw 37 27 ( ( -LRB- cord-011302-pfepyvaw 37 28 ISAT ISAT NNP cord-011302-pfepyvaw 37 29 ) ) -RRB- cord-011302-pfepyvaw 37 30 [ [ -LRB- cord-011302-pfepyvaw 37 31 25 25 CD cord-011302-pfepyvaw 37 32 ] ] -RRB- cord-011302-pfepyvaw 37 33 . . . cord-011302-pfepyvaw 38 1 Subsequent subsequent JJ cord-011302-pfepyvaw 38 2 sub sub JJ cord-011302-pfepyvaw 38 3 - - JJ cord-011302-pfepyvaw 38 4 group group JJ cord-011302-pfepyvaw 38 5 analysis analysis NN cord-011302-pfepyvaw 38 6 of of IN cord-011302-pfepyvaw 38 7 patients patient NNS cord-011302-pfepyvaw 38 8 aged age VBN cord-011302-pfepyvaw 38 9 65 65 CD cord-011302-pfepyvaw 38 10 years year NNS cord-011302-pfepyvaw 38 11 and and CC cord-011302-pfepyvaw 38 12 over over RB cord-011302-pfepyvaw 38 13 suggested suggest VBD cord-011302-pfepyvaw 38 14 a a DT cord-011302-pfepyvaw 38 15 trend trend NN cord-011302-pfepyvaw 38 16 towards towards IN cord-011302-pfepyvaw 38 17 better well JJR cord-011302-pfepyvaw 38 18 outcomes outcome NNS cord-011302-pfepyvaw 38 19 with with IN cord-011302-pfepyvaw 38 20 endovascular endovascular JJ cord-011302-pfepyvaw 38 21 treatment treatment NN cord-011302-pfepyvaw 38 22 compared compare VBN cord-011302-pfepyvaw 38 23 to to IN cord-011302-pfepyvaw 38 24 clipping clip VBG cord-011302-pfepyvaw 38 25 , , , cord-011302-pfepyvaw 38 26 although although IN cord-011302-pfepyvaw 38 27 this this DT cord-011302-pfepyvaw 38 28 was be VBD cord-011302-pfepyvaw 38 29 subject subject JJ cord-011302-pfepyvaw 38 30 to to IN cord-011302-pfepyvaw 38 31 aneurysm aneurysm NN cord-011302-pfepyvaw 38 32 location location NN cord-011302-pfepyvaw 38 33 [ [ -LRB- cord-011302-pfepyvaw 38 34 30 30 CD cord-011302-pfepyvaw 38 35 ] ] -RRB- cord-011302-pfepyvaw 38 36 . . . cord-011302-pfepyvaw 39 1 Lower low JJR cord-011302-pfepyvaw 39 2 rates rate NNS cord-011302-pfepyvaw 39 3 of of IN cord-011302-pfepyvaw 39 4 infectious infectious JJ cord-011302-pfepyvaw 39 5 and and CC cord-011302-pfepyvaw 39 6 pulmonary pulmonary JJ cord-011302-pfepyvaw 39 7 complications complication NNS cord-011302-pfepyvaw 39 8 and and CC cord-011302-pfepyvaw 39 9 epilepsy epilepsy NN cord-011302-pfepyvaw 39 10 occurred occur VBD cord-011302-pfepyvaw 39 11 in in IN cord-011302-pfepyvaw 39 12 the the DT cord-011302-pfepyvaw 39 13 endovascular endovascular JJ cord-011302-pfepyvaw 39 14 group group NN cord-011302-pfepyvaw 39 15 . . . cord-011302-pfepyvaw 40 1 This this DT cord-011302-pfepyvaw 40 2 was be VBD cord-011302-pfepyvaw 40 3 supported support VBN cord-011302-pfepyvaw 40 4 by by IN cord-011302-pfepyvaw 40 5 the the DT cord-011302-pfepyvaw 40 6 Barrow Barrow NNP cord-011302-pfepyvaw 40 7 Ruptured rupture VBD cord-011302-pfepyvaw 40 8 Aneurysm Aneurysm NNP cord-011302-pfepyvaw 40 9 Trial Trial NNP cord-011302-pfepyvaw 40 10 ( ( -LRB- cord-011302-pfepyvaw 40 11 BRAT BRAT NNP cord-011302-pfepyvaw 40 12 ) ) -RRB- cord-011302-pfepyvaw 40 13 which which WDT cord-011302-pfepyvaw 40 14 showed show VBD cord-011302-pfepyvaw 40 15 significantly significantly RB cord-011302-pfepyvaw 40 16 poorer poor JJR cord-011302-pfepyvaw 40 17 outcomes outcome NNS cord-011302-pfepyvaw 40 18 at at IN cord-011302-pfepyvaw 40 19 1 1 CD cord-011302-pfepyvaw 40 20 year year NN cord-011302-pfepyvaw 40 21 in in IN cord-011302-pfepyvaw 40 22 patients patient NNS cord-011302-pfepyvaw 40 23 over over IN cord-011302-pfepyvaw 40 24 50 50 CD cord-011302-pfepyvaw 40 25 years year NNS cord-011302-pfepyvaw 40 26 old old JJ cord-011302-pfepyvaw 40 27 treated treat VBN cord-011302-pfepyvaw 40 28 with with IN cord-011302-pfepyvaw 40 29 clipping clip VBG cord-011302-pfepyvaw 40 30 [ [ -LRB- cord-011302-pfepyvaw 40 31 21 21 CD cord-011302-pfepyvaw 40 32 ] ] -RRB- cord-011302-pfepyvaw 40 33 . . . cord-011302-pfepyvaw 41 1 A a DT cord-011302-pfepyvaw 41 2 recent recent JJ cord-011302-pfepyvaw 41 3 systematic systematic JJ cord-011302-pfepyvaw 41 4 review review NN cord-011302-pfepyvaw 41 5 of of IN cord-011302-pfepyvaw 41 6 endovascular endovascular JJ cord-011302-pfepyvaw 41 7 treatment treatment NN cord-011302-pfepyvaw 41 8 of of IN cord-011302-pfepyvaw 41 9 ruptured ruptured JJ cord-011302-pfepyvaw 41 10 aneurysms aneurysm NNS cord-011302-pfepyvaw 41 11 in in IN cord-011302-pfepyvaw 41 12 patients patient NNS cord-011302-pfepyvaw 41 13 aged age VBN cord-011302-pfepyvaw 41 14 over over IN cord-011302-pfepyvaw 41 15 65 65 CD cord-011302-pfepyvaw 41 16 reported report VBD cord-011302-pfepyvaw 41 17 good good JJ cord-011302-pfepyvaw 41 18 outcomes outcome NNS cord-011302-pfepyvaw 41 19 in in IN cord-011302-pfepyvaw 41 20 66 66 CD cord-011302-pfepyvaw 41 21 % % NN cord-011302-pfepyvaw 41 22 , , , cord-011302-pfepyvaw 41 23 with with IN cord-011302-pfepyvaw 41 24 a a DT cord-011302-pfepyvaw 41 25 mortality mortality NN cord-011302-pfepyvaw 41 26 rate rate NN cord-011302-pfepyvaw 41 27 of of IN cord-011302-pfepyvaw 41 28 around around IN cord-011302-pfepyvaw 41 29 26 26 CD cord-011302-pfepyvaw 41 30 % % NN cord-011302-pfepyvaw 41 31 at at IN cord-011302-pfepyvaw 41 32 1 1 CD cord-011302-pfepyvaw 41 33 year year NN cord-011302-pfepyvaw 41 34 [ [ -LRB- cord-011302-pfepyvaw 41 35 36 36 CD cord-011302-pfepyvaw 41 36 ] ] -RRB- cord-011302-pfepyvaw 41 37 . . . cord-011302-pfepyvaw 42 1 With with IN cord-011302-pfepyvaw 42 2 an an DT cord-011302-pfepyvaw 42 3 86 86 CD cord-011302-pfepyvaw 42 4 % % NN cord-011302-pfepyvaw 42 5 complete complete JJ cord-011302-pfepyvaw 42 6 or or CC cord-011302-pfepyvaw 42 7 near near RB cord-011302-pfepyvaw 42 8 - - HYPH cord-011302-pfepyvaw 42 9 complete complete JJ cord-011302-pfepyvaw 42 10 occlusion occlusion NN cord-011302-pfepyvaw 42 11 rate rate NN cord-011302-pfepyvaw 42 12 at at IN cord-011302-pfepyvaw 42 13 long long JJ cord-011302-pfepyvaw 42 14 - - HYPH cord-011302-pfepyvaw 42 15 term term NN cord-011302-pfepyvaw 42 16 follow follow NN cord-011302-pfepyvaw 42 17 - - HYPH cord-011302-pfepyvaw 42 18 up up NN cord-011302-pfepyvaw 42 19 , , , cord-011302-pfepyvaw 42 20 endovascular endovascular JJ cord-011302-pfepyvaw 42 21 treatment treatment NN cord-011302-pfepyvaw 42 22 is be VBZ cord-011302-pfepyvaw 42 23 preferred prefer VBN cord-011302-pfepyvaw 42 24 to to IN cord-011302-pfepyvaw 42 25 clipping clip VBG cord-011302-pfepyvaw 42 26 and and CC cord-011302-pfepyvaw 42 27 probably probably RB cord-011302-pfepyvaw 42 28 reduces reduce VBZ cord-011302-pfepyvaw 42 29 risks risk NNS cord-011302-pfepyvaw 42 30 for for IN cord-011302-pfepyvaw 42 31 older old JJR cord-011302-pfepyvaw 42 32 patients patient NNS cord-011302-pfepyvaw 42 33 . . . cord-011302-pfepyvaw 43 1 Koffijberg Koffijberg NNP cord-011302-pfepyvaw 43 2 analysed analyse VBD cord-011302-pfepyvaw 43 3 the the DT cord-011302-pfepyvaw 43 4 cost cost NN cord-011302-pfepyvaw 43 5 - - HYPH cord-011302-pfepyvaw 43 6 effectiveness effectiveness NN cord-011302-pfepyvaw 43 7 of of IN cord-011302-pfepyvaw 43 8 treating treat VBG cord-011302-pfepyvaw 43 9 ruptured rupture VBN cord-011302-pfepyvaw 43 10 aneurysms aneurysm NNS cord-011302-pfepyvaw 43 11 in in IN cord-011302-pfepyvaw 43 12 patients patient NNS cord-011302-pfepyvaw 43 13 aged age VBN cord-011302-pfepyvaw 43 14 over over IN cord-011302-pfepyvaw 43 15 70 70 CD cord-011302-pfepyvaw 43 16 , , , cord-011302-pfepyvaw 43 17 identifying identify VBG cord-011302-pfepyvaw 43 18 key key JJ cord-011302-pfepyvaw 43 19 parameters parameter NNS cord-011302-pfepyvaw 43 20 including include VBG cord-011302-pfepyvaw 43 21 patient patient JJ cord-011302-pfepyvaw 43 22 age age NN cord-011302-pfepyvaw 43 23 ( ( -LRB- cord-011302-pfepyvaw 43 24 and and CC cord-011302-pfepyvaw 43 25 thus thus RB cord-011302-pfepyvaw 43 26 life life NN cord-011302-pfepyvaw 43 27 expectancy expectancy NN cord-011302-pfepyvaw 43 28 ) ) -RRB- cord-011302-pfepyvaw 43 29 , , , cord-011302-pfepyvaw 43 30 good good JJ cord-011302-pfepyvaw 43 31 or or CC cord-011302-pfepyvaw 43 32 poor poor JJ cord-011302-pfepyvaw 43 33 clinical clinical JJ cord-011302-pfepyvaw 43 34 condition condition NN cord-011302-pfepyvaw 43 35 on on IN cord-011302-pfepyvaw 43 36 presentation presentation NN cord-011302-pfepyvaw 43 37 , , , cord-011302-pfepyvaw 43 38 conservative conservative JJ cord-011302-pfepyvaw 43 39 or or CC cord-011302-pfepyvaw 43 40 occlusive occlusive JJ cord-011302-pfepyvaw 43 41 treatment treatment NN cord-011302-pfepyvaw 43 42 ( ( -LRB- cord-011302-pfepyvaw 43 43 clipping clip VBG cord-011302-pfepyvaw 43 44 or or CC cord-011302-pfepyvaw 43 45 coiling coil VBG cord-011302-pfepyvaw 43 46 ) ) -RRB- cord-011302-pfepyvaw 43 47 and and CC cord-011302-pfepyvaw 43 48 good good JJ cord-011302-pfepyvaw 43 49 or or CC cord-011302-pfepyvaw 43 50 poor poor JJ cord-011302-pfepyvaw 43 51 outcomes outcome NNS cord-011302-pfepyvaw 43 52 [ [ -LRB- cord-011302-pfepyvaw 43 53 18 18 CD cord-011302-pfepyvaw 43 54 ] ] -RRB- cord-011302-pfepyvaw 43 55 . . . cord-011302-pfepyvaw 44 1 Perhaps perhaps RB cord-011302-pfepyvaw 44 2 surprisingly surprisingly RB cord-011302-pfepyvaw 44 3 , , , cord-011302-pfepyvaw 44 4 occlusive occlusive JJ cord-011302-pfepyvaw 44 5 treatment treatment NN cord-011302-pfepyvaw 44 6 of of IN cord-011302-pfepyvaw 44 7 aneurysms aneurysm NNS cord-011302-pfepyvaw 44 8 translated translate VBN cord-011302-pfepyvaw 44 9 into into IN cord-011302-pfepyvaw 44 10 a a DT cord-011302-pfepyvaw 44 11 health health NN cord-011302-pfepyvaw 44 12 benefit benefit NN cord-011302-pfepyvaw 44 13 for for IN cord-011302-pfepyvaw 44 14 all all DT cord-011302-pfepyvaw 44 15 older old JJR cord-011302-pfepyvaw 44 16 patients patient NNS cord-011302-pfepyvaw 44 17 presenting present VBG cord-011302-pfepyvaw 44 18 within within IN cord-011302-pfepyvaw 44 19 4 4 CD cord-011302-pfepyvaw 44 20 days day NNS cord-011302-pfepyvaw 44 21 of of IN cord-011302-pfepyvaw 44 22 SAH SAH NNP cord-011302-pfepyvaw 44 23 , , , cord-011302-pfepyvaw 44 24 regardless regardless RB cord-011302-pfepyvaw 44 25 of of IN cord-011302-pfepyvaw 44 26 the the DT cord-011302-pfepyvaw 44 27 good good JJ cord-011302-pfepyvaw 44 28 or or CC cord-011302-pfepyvaw 44 29 poor poor JJ cord-011302-pfepyvaw 44 30 condition condition NN cord-011302-pfepyvaw 44 31 at at IN cord-011302-pfepyvaw 44 32 presentation presentation NN cord-011302-pfepyvaw 44 33 . . . cord-011302-pfepyvaw 45 1 A a DT cord-011302-pfepyvaw 45 2 later later JJ cord-011302-pfepyvaw 45 3 presentation presentation NN cord-011302-pfepyvaw 45 4 , , , cord-011302-pfepyvaw 45 5 particularly particularly RB cord-011302-pfepyvaw 45 6 10 10 CD cord-011302-pfepyvaw 45 7 days day NNS cord-011302-pfepyvaw 45 8 or or CC cord-011302-pfepyvaw 45 9 more more JJR cord-011302-pfepyvaw 45 10 after after IN cord-011302-pfepyvaw 45 11 SAH SAH NNP cord-011302-pfepyvaw 45 12 , , , cord-011302-pfepyvaw 45 13 was be VBD cord-011302-pfepyvaw 45 14 more more RBR cord-011302-pfepyvaw 45 15 likely likely JJ cord-011302-pfepyvaw 45 16 to to TO cord-011302-pfepyvaw 45 17 result result VB cord-011302-pfepyvaw 45 18 in in IN cord-011302-pfepyvaw 45 19 no no DT cord-011302-pfepyvaw 45 20 or or CC cord-011302-pfepyvaw 45 21 minimal minimal JJ cord-011302-pfepyvaw 45 22 treatment treatment NN cord-011302-pfepyvaw 45 23 benefits benefit NNS cord-011302-pfepyvaw 45 24 . . . cord-011302-pfepyvaw 46 1 However however RB cord-011302-pfepyvaw 46 2 , , , cord-011302-pfepyvaw 46 3 occlusive occlusive JJ cord-011302-pfepyvaw 46 4 treatment treatment NN cord-011302-pfepyvaw 46 5 was be VBD cord-011302-pfepyvaw 46 6 only only RB cord-011302-pfepyvaw 46 7 found find VBN cord-011302-pfepyvaw 46 8 to to TO cord-011302-pfepyvaw 46 9 be be VB cord-011302-pfepyvaw 46 10 cost cost NN cord-011302-pfepyvaw 46 11 - - HYPH cord-011302-pfepyvaw 46 12 effective effective JJ cord-011302-pfepyvaw 46 13 in in IN cord-011302-pfepyvaw 46 14 women woman NNS cord-011302-pfepyvaw 46 15 aged age VBN cord-011302-pfepyvaw 46 16 70 70 CD cord-011302-pfepyvaw 46 17 - - SYM cord-011302-pfepyvaw 46 18 79 79 CD cord-011302-pfepyvaw 46 19 , , , cord-011302-pfepyvaw 46 20 and and CC cord-011302-pfepyvaw 46 21 men man NNS cord-011302-pfepyvaw 46 22 aged age VBD cord-011302-pfepyvaw 46 23 70 70 CD cord-011302-pfepyvaw 46 24 - - SYM cord-011302-pfepyvaw 46 25 74 74 CD cord-011302-pfepyvaw 46 26 presenting present VBG cord-011302-pfepyvaw 46 27 in in IN cord-011302-pfepyvaw 46 28 a a DT cord-011302-pfepyvaw 46 29 good good JJ cord-011302-pfepyvaw 46 30 condition condition NN cord-011302-pfepyvaw 46 31 , , , cord-011302-pfepyvaw 46 32 within within IN cord-011302-pfepyvaw 46 33 4 4 CD cord-011302-pfepyvaw 46 34 days day NNS cord-011302-pfepyvaw 46 35 of of IN cord-011302-pfepyvaw 46 36 SAH SAH NNP cord-011302-pfepyvaw 46 37 . . . cord-011302-pfepyvaw 47 1 Thus thus RB cord-011302-pfepyvaw 47 2 , , , cord-011302-pfepyvaw 47 3 although although IN cord-011302-pfepyvaw 47 4 potentially potentially RB cord-011302-pfepyvaw 47 5 offering offer VBG cord-011302-pfepyvaw 47 6 some some DT cord-011302-pfepyvaw 47 7 clinical clinical JJ cord-011302-pfepyvaw 47 8 benefit benefit NN cord-011302-pfepyvaw 47 9 , , , cord-011302-pfepyvaw 47 10 occlusive occlusive JJ cord-011302-pfepyvaw 47 11 treatment treatment NN cord-011302-pfepyvaw 47 12 is be VBZ cord-011302-pfepyvaw 47 13 clearly clearly RB cord-011302-pfepyvaw 47 14 more more RBR cord-011302-pfepyvaw 47 15 costly costly JJ cord-011302-pfepyvaw 47 16 than than IN cord-011302-pfepyvaw 47 17 conservative conservative JJ cord-011302-pfepyvaw 47 18 management management NN cord-011302-pfepyvaw 47 19 and and CC cord-011302-pfepyvaw 47 20 may may MD cord-011302-pfepyvaw 47 21 be be VB cord-011302-pfepyvaw 47 22 particularly particularly RB cord-011302-pfepyvaw 47 23 difficult difficult JJ cord-011302-pfepyvaw 47 24 to to TO cord-011302-pfepyvaw 47 25 justify justify VB cord-011302-pfepyvaw 47 26 in in IN cord-011302-pfepyvaw 47 27 those those DT cord-011302-pfepyvaw 47 28 aged age VBN cord-011302-pfepyvaw 47 29 80 80 CD cord-011302-pfepyvaw 47 30 years year NNS cord-011302-pfepyvaw 47 31 and and CC cord-011302-pfepyvaw 47 32 over over IN cord-011302-pfepyvaw 47 33 presenting present VBG cord-011302-pfepyvaw 47 34 in in IN cord-011302-pfepyvaw 47 35 a a DT cord-011302-pfepyvaw 47 36 poor poor JJ cord-011302-pfepyvaw 47 37 condition condition NN cord-011302-pfepyvaw 47 38 . . . cord-011302-pfepyvaw 48 1 It -PRON- PRP cord-011302-pfepyvaw 48 2 is be VBZ cord-011302-pfepyvaw 48 3 , , , cord-011302-pfepyvaw 48 4 however however RB cord-011302-pfepyvaw 48 5 , , , cord-011302-pfepyvaw 48 6 also also RB cord-011302-pfepyvaw 48 7 important important JJ cord-011302-pfepyvaw 48 8 to to TO cord-011302-pfepyvaw 48 9 highlight highlight VB cord-011302-pfepyvaw 48 10 that that IN cord-011302-pfepyvaw 48 11 studies study NNS cord-011302-pfepyvaw 48 12 assessing assess VBG cord-011302-pfepyvaw 48 13 interventions intervention NNS cord-011302-pfepyvaw 48 14 such such JJ cord-011302-pfepyvaw 48 15 as as IN cord-011302-pfepyvaw 48 16 this this DT cord-011302-pfepyvaw 48 17 will will MD cord-011302-pfepyvaw 48 18 contain contain VB cord-011302-pfepyvaw 48 19 inherent inherent JJ cord-011302-pfepyvaw 48 20 selection selection NN cord-011302-pfepyvaw 48 21 bias bias NN cord-011302-pfepyvaw 48 22 , , , cord-011302-pfepyvaw 48 23 by by IN cord-011302-pfepyvaw 48 24 virtue virtue NN cord-011302-pfepyvaw 48 25 of of IN cord-011302-pfepyvaw 48 26 the the DT cord-011302-pfepyvaw 48 27 fact fact NN cord-011302-pfepyvaw 48 28 that that IN cord-011302-pfepyvaw 48 29 the the DT cord-011302-pfepyvaw 48 30 patients patient NNS cord-011302-pfepyvaw 48 31 undergoing undergo VBG cord-011302-pfepyvaw 48 32 intervention intervention NN cord-011302-pfepyvaw 48 33 differ differ VBP cord-011302-pfepyvaw 48 34 from from IN cord-011302-pfepyvaw 48 35 those those DT cord-011302-pfepyvaw 48 36 that that WDT cord-011302-pfepyvaw 48 37 were be VBD cord-011302-pfepyvaw 48 38 not not RB cord-011302-pfepyvaw 48 39 . . . cord-011302-pfepyvaw 49 1 Such such JJ cord-011302-pfepyvaw 49 2 results result NNS cord-011302-pfepyvaw 49 3 should should MD cord-011302-pfepyvaw 49 4 be be VB cord-011302-pfepyvaw 49 5 treated treat VBN cord-011302-pfepyvaw 49 6 with with IN cord-011302-pfepyvaw 49 7 caution caution NN cord-011302-pfepyvaw 49 8 until until IN cord-011302-pfepyvaw 49 9 clear clear JJ cord-011302-pfepyvaw 49 10 , , , cord-011302-pfepyvaw 49 11 prospective prospective JJ cord-011302-pfepyvaw 49 12 , , , cord-011302-pfepyvaw 49 13 evidence evidence NN cord-011302-pfepyvaw 49 14 is be VBZ cord-011302-pfepyvaw 49 15 available available JJ cord-011302-pfepyvaw 49 16 . . . cord-011302-pfepyvaw 50 1 It -PRON- PRP cord-011302-pfepyvaw 50 2 is be VBZ cord-011302-pfepyvaw 50 3 apparent apparent JJ cord-011302-pfepyvaw 50 4 that that IN cord-011302-pfepyvaw 50 5 patients patient NNS cord-011302-pfepyvaw 50 6 presenting present VBG cord-011302-pfepyvaw 50 7 in in IN cord-011302-pfepyvaw 50 8 a a DT cord-011302-pfepyvaw 50 9 poor poor JJ cord-011302-pfepyvaw 50 10 condition condition NN cord-011302-pfepyvaw 50 11 and and CC cord-011302-pfepyvaw 50 12 aged age VBN cord-011302-pfepyvaw 50 13 over over IN cord-011302-pfepyvaw 50 14 70 70 CD cord-011302-pfepyvaw 50 15 are be VBP cord-011302-pfepyvaw 50 16 likely likely JJ cord-011302-pfepyvaw 50 17 to to TO cord-011302-pfepyvaw 50 18 have have VB cord-011302-pfepyvaw 50 19 a a DT cord-011302-pfepyvaw 50 20 poor poor JJ cord-011302-pfepyvaw 50 21 outcome outcome NN cord-011302-pfepyvaw 50 22 , , , cord-011302-pfepyvaw 50 23 and and CC cord-011302-pfepyvaw 50 24 a a DT cord-011302-pfepyvaw 50 25 conservative conservative JJ cord-011302-pfepyvaw 50 26 approach approach NN cord-011302-pfepyvaw 50 27 may may MD cord-011302-pfepyvaw 50 28 be be VB cord-011302-pfepyvaw 50 29 appropriate appropriate JJ cord-011302-pfepyvaw 50 30 in in IN cord-011302-pfepyvaw 50 31 these these DT cord-011302-pfepyvaw 50 32 patients patient NNS cord-011302-pfepyvaw 50 33 . . . cord-011302-pfepyvaw 51 1 More More JJR cord-011302-pfepyvaw 51 2 prospective prospective JJ cord-011302-pfepyvaw 51 3 research research NN cord-011302-pfepyvaw 51 4 is be VBZ cord-011302-pfepyvaw 51 5 needed need VBN cord-011302-pfepyvaw 51 6 to to TO cord-011302-pfepyvaw 51 7 understand understand VB cord-011302-pfepyvaw 51 8 the the DT cord-011302-pfepyvaw 51 9 risk risk NN cord-011302-pfepyvaw 51 10 - - HYPH cord-011302-pfepyvaw 51 11 benefit benefit NN cord-011302-pfepyvaw 51 12 profile profile NN cord-011302-pfepyvaw 51 13 of of IN cord-011302-pfepyvaw 51 14 treating treat VBG cord-011302-pfepyvaw 51 15 well well NN cord-011302-pfepyvaw 51 16 patients patient NNS cord-011302-pfepyvaw 51 17 , , , cord-011302-pfepyvaw 51 18 particularly particularly RB cord-011302-pfepyvaw 51 19 those those DT cord-011302-pfepyvaw 51 20 aged age VBN cord-011302-pfepyvaw 51 21 over over IN cord-011302-pfepyvaw 51 22 80 80 CD cord-011302-pfepyvaw 51 23 . . . cord-011302-pfepyvaw 52 1 The the DT cord-011302-pfepyvaw 52 2 current current JJ cord-011302-pfepyvaw 52 3 literature literature NN cord-011302-pfepyvaw 52 4 supports support VBZ cord-011302-pfepyvaw 52 5 active active JJ cord-011302-pfepyvaw 52 6 intervention intervention NN cord-011302-pfepyvaw 52 7 for for IN cord-011302-pfepyvaw 52 8 those those DT cord-011302-pfepyvaw 52 9 under under IN cord-011302-pfepyvaw 52 10 80 80 CD cord-011302-pfepyvaw 52 11 , , , cord-011302-pfepyvaw 52 12 with with IN cord-011302-pfepyvaw 52 13 an an DT cord-011302-pfepyvaw 52 14 awareness awareness NN cord-011302-pfepyvaw 52 15 of of IN cord-011302-pfepyvaw 52 16 the the DT cord-011302-pfepyvaw 52 17 increased increase VBN cord-011302-pfepyvaw 52 18 risk risk NN cord-011302-pfepyvaw 52 19 of of IN cord-011302-pfepyvaw 52 20 complications complication NNS cord-011302-pfepyvaw 52 21 , , , cord-011302-pfepyvaw 52 22 but but CC cord-011302-pfepyvaw 52 23 more more JJR cord-011302-pfepyvaw 52 24 data datum NNS cord-011302-pfepyvaw 52 25 are be VBP cord-011302-pfepyvaw 52 26 needed need VBN cord-011302-pfepyvaw 52 27 specifically specifically RB cord-011302-pfepyvaw 52 28 in in IN cord-011302-pfepyvaw 52 29 relation relation NN cord-011302-pfepyvaw 52 30 to to IN cord-011302-pfepyvaw 52 31 outcomes outcome NNS cord-011302-pfepyvaw 52 32 with with IN cord-011302-pfepyvaw 52 33 endovascular endovascular JJ cord-011302-pfepyvaw 52 34 intervention intervention NN cord-011302-pfepyvaw 52 35 . . . cord-011302-pfepyvaw 53 1 The the DT cord-011302-pfepyvaw 53 2 vast vast JJ cord-011302-pfepyvaw 53 3 majority majority NN cord-011302-pfepyvaw 53 4 of of IN cord-011302-pfepyvaw 53 5 older old JJR cord-011302-pfepyvaw 53 6 patients patient NNS cord-011302-pfepyvaw 53 7 admitted admit VBN cord-011302-pfepyvaw 53 8 to to IN cord-011302-pfepyvaw 53 9 a a DT cord-011302-pfepyvaw 53 10 neurosurgical neurosurgical JJ cord-011302-pfepyvaw 53 11 unit unit NN cord-011302-pfepyvaw 53 12 with with IN cord-011302-pfepyvaw 53 13 head head NN cord-011302-pfepyvaw 53 14 injury injury NN cord-011302-pfepyvaw 53 15 have have VBP cord-011302-pfepyvaw 53 16 a a DT cord-011302-pfepyvaw 53 17 subdural subdural JJ cord-011302-pfepyvaw 53 18 haematoma haematoma NN cord-011302-pfepyvaw 53 19 , , , cord-011302-pfepyvaw 53 20 most most RBS cord-011302-pfepyvaw 53 21 commonly commonly RB cord-011302-pfepyvaw 53 22 chronic chronic JJ cord-011302-pfepyvaw 53 23 subdural subdural JJ cord-011302-pfepyvaw 53 24 haematoma haematoma NN cord-011302-pfepyvaw 53 25 ( ( -LRB- cord-011302-pfepyvaw 53 26 CSDH CSDH NNP cord-011302-pfepyvaw 53 27 ) ) -RRB- cord-011302-pfepyvaw 53 28 , , , cord-011302-pfepyvaw 53 29 followed follow VBN cord-011302-pfepyvaw 53 30 by by IN cord-011302-pfepyvaw 53 31 mixed mixed JJ cord-011302-pfepyvaw 53 32 and and CC cord-011302-pfepyvaw 53 33 then then RB cord-011302-pfepyvaw 53 34 acute acute JJ cord-011302-pfepyvaw 53 35 subdural subdural JJ cord-011302-pfepyvaw 53 36 haematoma haematoma NN cord-011302-pfepyvaw 53 37 ( ( -LRB- cord-011302-pfepyvaw 53 38 ASDH ASDH NNP cord-011302-pfepyvaw 53 39 ) ) -RRB- cord-011302-pfepyvaw 53 40 [ [ -LRB- cord-011302-pfepyvaw 53 41 41 41 CD cord-011302-pfepyvaw 53 42 ] ] -RRB- cord-011302-pfepyvaw 53 43 . . . cord-011302-pfepyvaw 54 1 A a DT cord-011302-pfepyvaw 54 2 CSDH CSDH NNP cord-011302-pfepyvaw 54 3 is be VBZ cord-011302-pfepyvaw 54 4 a a DT cord-011302-pfepyvaw 54 5 condition condition NN cord-011302-pfepyvaw 54 6 almost almost RB cord-011302-pfepyvaw 54 7 exclusively exclusively RB cord-011302-pfepyvaw 54 8 confined confine VBN cord-011302-pfepyvaw 54 9 to to IN cord-011302-pfepyvaw 54 10 the the DT cord-011302-pfepyvaw 54 11 elderly elderly JJ cord-011302-pfepyvaw 54 12 , , , cord-011302-pfepyvaw 54 13 with with IN cord-011302-pfepyvaw 54 14 a a DT cord-011302-pfepyvaw 54 15 median median JJ cord-011302-pfepyvaw 54 16 age age NN cord-011302-pfepyvaw 54 17 of of IN cord-011302-pfepyvaw 54 18 77 77 CD cord-011302-pfepyvaw 54 19 in in IN cord-011302-pfepyvaw 54 20 the the DT cord-011302-pfepyvaw 54 21 UK UK NNP cord-011302-pfepyvaw 54 22 [ [ -LRB- cord-011302-pfepyvaw 54 23 4 4 CD cord-011302-pfepyvaw 54 24 ] ] -RRB- cord-011302-pfepyvaw 54 25 . . . cord-011302-pfepyvaw 55 1 The the DT cord-011302-pfepyvaw 55 2 post post JJ cord-011302-pfepyvaw 55 3 - - JJ cord-011302-pfepyvaw 55 4 traumatic traumatic JJ cord-011302-pfepyvaw 55 5 pathophysiology pathophysiology NN cord-011302-pfepyvaw 55 6 is be VBZ cord-011302-pfepyvaw 55 7 complex complex JJ cord-011302-pfepyvaw 55 8 ; ; : cord-011302-pfepyvaw 55 9 it -PRON- PRP cord-011302-pfepyvaw 55 10 takes take VBZ cord-011302-pfepyvaw 55 11 weeks week NNS cord-011302-pfepyvaw 55 12 to to IN cord-011302-pfepyvaw 55 13 months month NNS cord-011302-pfepyvaw 55 14 for for IN cord-011302-pfepyvaw 55 15 the the DT cord-011302-pfepyvaw 55 16 collection collection NN cord-011302-pfepyvaw 55 17 of of IN cord-011302-pfepyvaw 55 18 blood blood NN cord-011302-pfepyvaw 55 19 and and CC cord-011302-pfepyvaw 55 20 fluid fluid NN cord-011302-pfepyvaw 55 21 to to TO cord-011302-pfepyvaw 55 22 expand expand VB cord-011302-pfepyvaw 55 23 : : : cord-011302-pfepyvaw 56 1 evidences evidence NNS cord-011302-pfepyvaw 56 2 support support VBP cord-011302-pfepyvaw 56 3 the the DT cord-011302-pfepyvaw 56 4 theory theory NN cord-011302-pfepyvaw 56 5 that that IN cord-011302-pfepyvaw 56 6 this this DT cord-011302-pfepyvaw 56 7 is be VBZ cord-011302-pfepyvaw 56 8 , , , cord-011302-pfepyvaw 56 9 at at IN cord-011302-pfepyvaw 56 10 least least JJS cord-011302-pfepyvaw 56 11 in in IN cord-011302-pfepyvaw 56 12 part part NN cord-011302-pfepyvaw 56 13 , , , cord-011302-pfepyvaw 56 14 due due IN cord-011302-pfepyvaw 56 15 to to IN cord-011302-pfepyvaw 56 16 an an DT cord-011302-pfepyvaw 56 17 escalating escalate VBG cord-011302-pfepyvaw 56 18 inflammatory inflammatory JJ cord-011302-pfepyvaw 56 19 process process NN cord-011302-pfepyvaw 56 20 [ [ -LRB- cord-011302-pfepyvaw 56 21 8 8 CD cord-011302-pfepyvaw 56 22 ] ] -RRB- cord-011302-pfepyvaw 56 23 . . . cord-011302-pfepyvaw 57 1 Many many JJ cord-011302-pfepyvaw 57 2 patients patient NNS cord-011302-pfepyvaw 57 3 have have VBP cord-011302-pfepyvaw 57 4 no no DT cord-011302-pfepyvaw 57 5 recollection recollection NN cord-011302-pfepyvaw 57 6 of of IN cord-011302-pfepyvaw 57 7 significant significant JJ cord-011302-pfepyvaw 57 8 trauma trauma NN cord-011302-pfepyvaw 57 9 and and CC cord-011302-pfepyvaw 57 10 presentation presentation NN cord-011302-pfepyvaw 57 11 is be VBZ cord-011302-pfepyvaw 57 12 usually usually RB cord-011302-pfepyvaw 57 13 with with IN cord-011302-pfepyvaw 57 14 cognitive cognitive JJ cord-011302-pfepyvaw 57 15 impairment impairment NN cord-011302-pfepyvaw 57 16 , , , cord-011302-pfepyvaw 57 17 gait gait JJ cord-011302-pfepyvaw 57 18 disturbance disturbance NN cord-011302-pfepyvaw 57 19 , , , cord-011302-pfepyvaw 57 20 limb limb NN cord-011302-pfepyvaw 57 21 weakness weakness NN cord-011302-pfepyvaw 57 22 , , , cord-011302-pfepyvaw 57 23 or or CC cord-011302-pfepyvaw 57 24 headache headache NN cord-011302-pfepyvaw 57 25 . . . cord-011302-pfepyvaw 58 1 The the DT cord-011302-pfepyvaw 58 2 mainstay mainstay NN cord-011302-pfepyvaw 58 3 of of IN cord-011302-pfepyvaw 58 4 treatment treatment NN cord-011302-pfepyvaw 58 5 has have VBZ cord-011302-pfepyvaw 58 6 been be VBN cord-011302-pfepyvaw 58 7 surgical surgical JJ cord-011302-pfepyvaw 58 8 drainage drainage NN cord-011302-pfepyvaw 58 9 [ [ -LRB- cord-011302-pfepyvaw 58 10 4 4 CD cord-011302-pfepyvaw 58 11 , , , cord-011302-pfepyvaw 58 12 31 31 CD cord-011302-pfepyvaw 58 13 ] ] -RRB- cord-011302-pfepyvaw 58 14 . . . cord-011302-pfepyvaw 59 1 However however RB cord-011302-pfepyvaw 59 2 , , , cord-011302-pfepyvaw 59 3 recent recent JJ cord-011302-pfepyvaw 59 4 trials trial NNS cord-011302-pfepyvaw 59 5 have have VBP cord-011302-pfepyvaw 59 6 focused focus VBN cord-011302-pfepyvaw 59 7 on on IN cord-011302-pfepyvaw 59 8 medical medical JJ cord-011302-pfepyvaw 59 9 treatments treatment NNS cord-011302-pfepyvaw 59 10 , , , cord-011302-pfepyvaw 59 11 such such JJ cord-011302-pfepyvaw 59 12 as as IN cord-011302-pfepyvaw 59 13 steroids steroid NNS cord-011302-pfepyvaw 59 14 , , , cord-011302-pfepyvaw 59 15 for for IN cord-011302-pfepyvaw 59 16 controlling control VBG cord-011302-pfepyvaw 59 17 the the DT cord-011302-pfepyvaw 59 18 inflammatory inflammatory JJ cord-011302-pfepyvaw 59 19 response response NN cord-011302-pfepyvaw 59 20 in in IN cord-011302-pfepyvaw 59 21 CSDH CSDH NNP cord-011302-pfepyvaw 59 22 , , , cord-011302-pfepyvaw 59 23 and and CC cord-011302-pfepyvaw 59 24 , , , cord-011302-pfepyvaw 59 25 therefore therefore RB cord-011302-pfepyvaw 59 26 , , , cord-011302-pfepyvaw 59 27 either either CC cord-011302-pfepyvaw 59 28 reducing reduce VBG cord-011302-pfepyvaw 59 29 CSDH CSDH NNP cord-011302-pfepyvaw 59 30 recurrence recurrence NN cord-011302-pfepyvaw 59 31 following follow VBG cord-011302-pfepyvaw 59 32 surgery surgery NN cord-011302-pfepyvaw 59 33 or or CC cord-011302-pfepyvaw 59 34 even even RB cord-011302-pfepyvaw 59 35 as as IN cord-011302-pfepyvaw 59 36 a a DT cord-011302-pfepyvaw 59 37 first first JJ cord-011302-pfepyvaw 59 38 - - HYPH cord-011302-pfepyvaw 59 39 line line NN cord-011302-pfepyvaw 59 40 treatment treatment NN cord-011302-pfepyvaw 59 41 [ [ -LRB- cord-011302-pfepyvaw 59 42 9 9 CD cord-011302-pfepyvaw 59 43 , , , cord-011302-pfepyvaw 59 44 15 15 CD cord-011302-pfepyvaw 59 45 , , , cord-011302-pfepyvaw 59 46 19 19 CD cord-011302-pfepyvaw 59 47 , , , cord-011302-pfepyvaw 59 48 24 24 CD cord-011302-pfepyvaw 59 49 ] ] -RRB- cord-011302-pfepyvaw 59 50 . . . cord-011302-pfepyvaw 60 1 Any any DT cord-011302-pfepyvaw 60 2 treatment treatment NN cord-011302-pfepyvaw 60 3 which which WDT cord-011302-pfepyvaw 60 4 reduces reduce VBZ cord-011302-pfepyvaw 60 5 CSDH CSDH NNP cord-011302-pfepyvaw 60 6 recurrence recurrence NN cord-011302-pfepyvaw 60 7 has have VBZ cord-011302-pfepyvaw 60 8 the the DT cord-011302-pfepyvaw 60 9 potential potential NN cord-011302-pfepyvaw 60 10 to to TO cord-011302-pfepyvaw 60 11 reduce reduce VB cord-011302-pfepyvaw 60 12 mortality mortality NN cord-011302-pfepyvaw 60 13 , , , cord-011302-pfepyvaw 60 14 which which WDT cord-011302-pfepyvaw 60 15 can can MD cord-011302-pfepyvaw 60 16 be be VB cord-011302-pfepyvaw 60 17 as as RB cord-011302-pfepyvaw 60 18 high high JJ cord-011302-pfepyvaw 60 19 as as IN cord-011302-pfepyvaw 60 20 18 18 CD cord-011302-pfepyvaw 60 21 % % NN cord-011302-pfepyvaw 60 22 at at IN cord-011302-pfepyvaw 60 23 6 6 CD cord-011302-pfepyvaw 60 24 months month NNS cord-011302-pfepyvaw 60 25 [ [ -LRB- cord-011302-pfepyvaw 60 26 31 31 CD cord-011302-pfepyvaw 60 27 ] ] -RRB- cord-011302-pfepyvaw 60 28 . . . cord-011302-pfepyvaw 61 1 The the DT cord-011302-pfepyvaw 61 2 outcome outcome NN cord-011302-pfepyvaw 61 3 of of IN cord-011302-pfepyvaw 61 4 these these DT cord-011302-pfepyvaw 61 5 steroid steroid NN cord-011302-pfepyvaw 61 6 trials trial NNS cord-011302-pfepyvaw 61 7 is be VBZ cord-011302-pfepyvaw 61 8 still still RB cord-011302-pfepyvaw 61 9 awaited await VBN cord-011302-pfepyvaw 61 10 , , , cord-011302-pfepyvaw 61 11 but but CC cord-011302-pfepyvaw 61 12 a a DT cord-011302-pfepyvaw 61 13 move move NN cord-011302-pfepyvaw 61 14 to to IN cord-011302-pfepyvaw 61 15 more more JJR cord-011302-pfepyvaw 61 16 conservative conservative JJ cord-011302-pfepyvaw 61 17 treatments treatment NNS cord-011302-pfepyvaw 61 18 of of IN cord-011302-pfepyvaw 61 19 CSDH CSDH NNP cord-011302-pfepyvaw 61 20 could could MD cord-011302-pfepyvaw 61 21 benefit benefit VB cord-011302-pfepyvaw 61 22 older old JJR cord-011302-pfepyvaw 61 23 patients patient NNS cord-011302-pfepyvaw 61 24 with with IN cord-011302-pfepyvaw 61 25 multiple multiple JJ cord-011302-pfepyvaw 61 26 co co NNS cord-011302-pfepyvaw 61 27 - - NNS cord-011302-pfepyvaw 61 28 morbidities morbidity NNS cord-011302-pfepyvaw 61 29 who who WP cord-011302-pfepyvaw 61 30 are be VBP cord-011302-pfepyvaw 61 31 at at IN cord-011302-pfepyvaw 61 32 increased increase VBN cord-011302-pfepyvaw 61 33 risk risk NN cord-011302-pfepyvaw 61 34 from from IN cord-011302-pfepyvaw 61 35 anaesthesia anaesthesia NN cord-011302-pfepyvaw 61 36 and and CC cord-011302-pfepyvaw 61 37 surgical surgical JJ cord-011302-pfepyvaw 61 38 treatment treatment NN cord-011302-pfepyvaw 61 39 . . . cord-011302-pfepyvaw 62 1 ASDHs asdh NNS cord-011302-pfepyvaw 62 2 are be VBP cord-011302-pfepyvaw 62 3 traditionally traditionally RB cord-011302-pfepyvaw 62 4 considered consider VBN cord-011302-pfepyvaw 62 5 to to TO cord-011302-pfepyvaw 62 6 occur occur VB cord-011302-pfepyvaw 62 7 in in IN cord-011302-pfepyvaw 62 8 higher high JJR cord-011302-pfepyvaw 62 9 impact impact NN cord-011302-pfepyvaw 62 10 trauma trauma NN cord-011302-pfepyvaw 62 11 , , , cord-011302-pfepyvaw 62 12 leading lead VBG cord-011302-pfepyvaw 62 13 to to IN cord-011302-pfepyvaw 62 14 coma coma NN cord-011302-pfepyvaw 62 15 and and CC cord-011302-pfepyvaw 62 16 hence hence RB cord-011302-pfepyvaw 62 17 a a DT cord-011302-pfepyvaw 62 18 poorer poor JJR cord-011302-pfepyvaw 62 19 prognosis prognosis NN cord-011302-pfepyvaw 62 20 , , , cord-011302-pfepyvaw 62 21 particularly particularly RB cord-011302-pfepyvaw 62 22 in in IN cord-011302-pfepyvaw 62 23 the the DT cord-011302-pfepyvaw 62 24 elderly elderly JJ cord-011302-pfepyvaw 62 25 . . . cord-011302-pfepyvaw 63 1 However however RB cord-011302-pfepyvaw 63 2 , , , cord-011302-pfepyvaw 63 3 due due IN cord-011302-pfepyvaw 63 4 to to IN cord-011302-pfepyvaw 63 5 co co JJ cord-011302-pfepyvaw 63 6 - - JJ cord-011302-pfepyvaw 63 7 existent existent JJ cord-011302-pfepyvaw 63 8 cerebral cerebral JJ cord-011302-pfepyvaw 63 9 atrophy atrophy NN cord-011302-pfepyvaw 63 10 in in IN cord-011302-pfepyvaw 63 11 older old JJR cord-011302-pfepyvaw 63 12 patients patient NNS cord-011302-pfepyvaw 63 13 , , , cord-011302-pfepyvaw 63 14 lower lower VB cord-011302-pfepyvaw 63 15 energy energy NN cord-011302-pfepyvaw 63 16 forces force NNS cord-011302-pfepyvaw 63 17 ( ( -LRB- cord-011302-pfepyvaw 63 18 falls fall VBZ cord-011302-pfepyvaw 63 19 ) ) -RRB- cord-011302-pfepyvaw 63 20 cause cause VB cord-011302-pfepyvaw 63 21 most most JJS cord-011302-pfepyvaw 63 22 traumatic traumatic JJ cord-011302-pfepyvaw 63 23 brain brain NN cord-011302-pfepyvaw 63 24 injuries injury NNS cord-011302-pfepyvaw 63 25 in in IN cord-011302-pfepyvaw 63 26 this this DT cord-011302-pfepyvaw 63 27 age age NN cord-011302-pfepyvaw 63 28 group group NN cord-011302-pfepyvaw 63 29 , , , cord-011302-pfepyvaw 63 30 and and CC cord-011302-pfepyvaw 63 31 the the DT cord-011302-pfepyvaw 63 32 onset onset NN cord-011302-pfepyvaw 63 33 of of IN cord-011302-pfepyvaw 63 34 neurological neurological JJ cord-011302-pfepyvaw 63 35 deterioration deterioration NN cord-011302-pfepyvaw 63 36 secondary secondary JJ cord-011302-pfepyvaw 63 37 to to IN cord-011302-pfepyvaw 63 38 an an DT cord-011302-pfepyvaw 63 39 ASDH ASDH NNP cord-011302-pfepyvaw 63 40 may may MD cord-011302-pfepyvaw 63 41 be be VB cord-011302-pfepyvaw 63 42 delayed delay VBN cord-011302-pfepyvaw 63 43 . . . cord-011302-pfepyvaw 64 1 This this DT cord-011302-pfepyvaw 64 2 provides provide VBZ cord-011302-pfepyvaw 64 3 an an DT cord-011302-pfepyvaw 64 4 opportunity opportunity NN cord-011302-pfepyvaw 64 5 for for IN cord-011302-pfepyvaw 64 6 definitive definitive JJ cord-011302-pfepyvaw 64 7 management management NN cord-011302-pfepyvaw 64 8 , , , cord-011302-pfepyvaw 64 9 following follow VBG cord-011302-pfepyvaw 64 10 an an DT cord-011302-pfepyvaw 64 11 early early JJ cord-011302-pfepyvaw 64 12 CT CT NNP cord-011302-pfepyvaw 64 13 scan scan NN cord-011302-pfepyvaw 64 14 , , , cord-011302-pfepyvaw 64 15 as as IN cord-011302-pfepyvaw 64 16 recommended recommend VBN cord-011302-pfepyvaw 64 17 by by IN cord-011302-pfepyvaw 64 18 NICE nice JJ cord-011302-pfepyvaw 64 19 guidelines guideline NNS cord-011302-pfepyvaw 64 20 [ [ -LRB- cord-011302-pfepyvaw 64 21 26 26 CD cord-011302-pfepyvaw 64 22 ] ] -RRB- cord-011302-pfepyvaw 64 23 . . . cord-011302-pfepyvaw 65 1 ASDH ASDH NNP cord-011302-pfepyvaw 65 2 following follow VBG cord-011302-pfepyvaw 65 3 a a DT cord-011302-pfepyvaw 65 4 minor minor JJ cord-011302-pfepyvaw 65 5 fall fall NN cord-011302-pfepyvaw 65 6 is be VBZ cord-011302-pfepyvaw 65 7 often often RB cord-011302-pfepyvaw 65 8 exacerbated exacerbate VBN cord-011302-pfepyvaw 65 9 by by IN cord-011302-pfepyvaw 65 10 the the DT cord-011302-pfepyvaw 65 11 fact fact NN cord-011302-pfepyvaw 65 12 that that IN cord-011302-pfepyvaw 65 13 nearly nearly RB cord-011302-pfepyvaw 65 14 two two CD cord-011302-pfepyvaw 65 15 - - HYPH cord-011302-pfepyvaw 65 16 third third NN cord-011302-pfepyvaw 65 17 of of IN cord-011302-pfepyvaw 65 18 these these DT cord-011302-pfepyvaw 65 19 patients patient NNS cord-011302-pfepyvaw 65 20 are be VBP cord-011302-pfepyvaw 65 21 on on IN cord-011302-pfepyvaw 65 22 anti anti JJ cord-011302-pfepyvaw 65 23 - - JJ cord-011302-pfepyvaw 65 24 thrombotic thrombotic JJ cord-011302-pfepyvaw 65 25 medications medication NNS cord-011302-pfepyvaw 65 26 [ [ -LRB- cord-011302-pfepyvaw 65 27 20 20 CD cord-011302-pfepyvaw 65 28 ] ] -RRB- cord-011302-pfepyvaw 65 29 . . . cord-011302-pfepyvaw 66 1 The the DT cord-011302-pfepyvaw 66 2 increased increase VBN cord-011302-pfepyvaw 66 3 use use NN cord-011302-pfepyvaw 66 4 of of IN cord-011302-pfepyvaw 66 5 these these DT cord-011302-pfepyvaw 66 6 medications medication NNS cord-011302-pfepyvaw 66 7 and and CC cord-011302-pfepyvaw 66 8 an an DT cord-011302-pfepyvaw 66 9 aging age VBG cord-011302-pfepyvaw 66 10 population population NN cord-011302-pfepyvaw 66 11 are be VBP cord-011302-pfepyvaw 66 12 probably probably RB cord-011302-pfepyvaw 66 13 contributing contribute VBG cord-011302-pfepyvaw 66 14 to to IN cord-011302-pfepyvaw 66 15 growing grow VBG cord-011302-pfepyvaw 66 16 rates rate NNS cord-011302-pfepyvaw 66 17 of of IN cord-011302-pfepyvaw 66 18 ASDH ASDH NNP cord-011302-pfepyvaw 66 19 in in IN cord-011302-pfepyvaw 66 20 the the DT cord-011302-pfepyvaw 66 21 elderly elderly JJ cord-011302-pfepyvaw 66 22 . . . cord-011302-pfepyvaw 67 1 A a DT cord-011302-pfepyvaw 67 2 recent recent JJ cord-011302-pfepyvaw 67 3 review review NN cord-011302-pfepyvaw 67 4 of of IN cord-011302-pfepyvaw 67 5 165 165 CD cord-011302-pfepyvaw 67 6 ASDHs asdh NNS cord-011302-pfepyvaw 67 7 in in IN cord-011302-pfepyvaw 67 8 a a DT cord-011302-pfepyvaw 67 9 German german JJ cord-011302-pfepyvaw 67 10 hospital hospital NN cord-011302-pfepyvaw 67 11 reported report VBD cord-011302-pfepyvaw 67 12 41.2 41.2 CD cord-011302-pfepyvaw 67 13 % % NN cord-011302-pfepyvaw 67 14 of of IN cord-011302-pfepyvaw 67 15 them -PRON- PRP cord-011302-pfepyvaw 67 16 occurring occur VBG cord-011302-pfepyvaw 67 17 in in IN cord-011302-pfepyvaw 67 18 patients patient NNS cord-011302-pfepyvaw 67 19 aged age VBN cord-011302-pfepyvaw 67 20 80 80 CD cord-011302-pfepyvaw 67 21 or or CC cord-011302-pfepyvaw 67 22 over over IN cord-011302-pfepyvaw 67 23 [ [ -LRB- cord-011302-pfepyvaw 67 24 44 44 CD cord-011302-pfepyvaw 67 25 ] ] -RRB- cord-011302-pfepyvaw 67 26 . . . cord-011302-pfepyvaw 68 1 Importantly importantly RB cord-011302-pfepyvaw 68 2 , , , cord-011302-pfepyvaw 68 3 although although IN cord-011302-pfepyvaw 68 4 90 90 CD cord-011302-pfepyvaw 68 5 % % NN cord-011302-pfepyvaw 68 6 of of IN cord-011302-pfepyvaw 68 7 the the DT cord-011302-pfepyvaw 68 8 patients patient NNS cord-011302-pfepyvaw 68 9 aged age VBN cord-011302-pfepyvaw 68 10 ≥ ≥ CD cord-011302-pfepyvaw 68 11 80 80 CD cord-011302-pfepyvaw 68 12 years year NNS cord-011302-pfepyvaw 68 13 of of IN cord-011302-pfepyvaw 68 14 age age NN cord-011302-pfepyvaw 68 15 underwent undergo VBD cord-011302-pfepyvaw 68 16 surgery surgery NN cord-011302-pfepyvaw 68 17 , , , cord-011302-pfepyvaw 68 18 only only RB cord-011302-pfepyvaw 68 19 24 24 CD cord-011302-pfepyvaw 68 20 % % NN cord-011302-pfepyvaw 68 21 experienced experience VBD cord-011302-pfepyvaw 68 22 a a DT cord-011302-pfepyvaw 68 23 favourable favourable JJ cord-011302-pfepyvaw 68 24 outcome outcome NN cord-011302-pfepyvaw 68 25 at at IN cord-011302-pfepyvaw 68 26 discharge discharge NN cord-011302-pfepyvaw 68 27 ( ( -LRB- cord-011302-pfepyvaw 68 28 Glasgow Glasgow NNP cord-011302-pfepyvaw 68 29 outcome outcome NN cord-011302-pfepyvaw 68 30 scale scale NN cord-011302-pfepyvaw 68 31 4 4 CD cord-011302-pfepyvaw 68 32 - - SYM cord-011302-pfepyvaw 68 33 5 5 CD cord-011302-pfepyvaw 68 34 ) ) -RRB- cord-011302-pfepyvaw 68 35 , , , cord-011302-pfepyvaw 68 36 increasing increase VBG cord-011302-pfepyvaw 68 37 to to IN cord-011302-pfepyvaw 68 38 36 36 CD cord-011302-pfepyvaw 68 39 % % NN cord-011302-pfepyvaw 68 40 at at IN cord-011302-pfepyvaw 68 41 3-months 3-months CD cord-011302-pfepyvaw 68 42 . . . cord-011302-pfepyvaw 69 1 The the DT cord-011302-pfepyvaw 69 2 mortality mortality NN cord-011302-pfepyvaw 69 3 rate rate NN cord-011302-pfepyvaw 69 4 was be VBD cord-011302-pfepyvaw 69 5 high high JJ cord-011302-pfepyvaw 69 6 , , , cord-011302-pfepyvaw 69 7 48 48 CD cord-011302-pfepyvaw 69 8 % % NN cord-011302-pfepyvaw 69 9 at at IN cord-011302-pfepyvaw 69 10 3 3 CD cord-011302-pfepyvaw 69 11 months month NNS cord-011302-pfepyvaw 69 12 , , , cord-011302-pfepyvaw 69 13 and and CC cord-011302-pfepyvaw 69 14 predictors predictor NNS cord-011302-pfepyvaw 69 15 of of IN cord-011302-pfepyvaw 69 16 an an DT cord-011302-pfepyvaw 69 17 unfavourable unfavourable JJ cord-011302-pfepyvaw 69 18 outcome outcome NN cord-011302-pfepyvaw 69 19 included include VBD cord-011302-pfepyvaw 69 20 > > XX cord-011302-pfepyvaw 69 21 5 5 CD cord-011302-pfepyvaw 69 22 co co NNS cord-011302-pfepyvaw 69 23 - - NNS cord-011302-pfepyvaw 69 24 morbidities morbidity NNS cord-011302-pfepyvaw 69 25 , , , cord-011302-pfepyvaw 69 26 GCS GCS NNP cord-011302-pfepyvaw 69 27 ≤ ≤ NNP cord-011302-pfepyvaw 69 28 8 8 CD cord-011302-pfepyvaw 69 29 at at IN cord-011302-pfepyvaw 69 30 admission admission NN cord-011302-pfepyvaw 69 31 and and CC cord-011302-pfepyvaw 69 32 24 24 CD cord-011302-pfepyvaw 69 33 hours hour NNS cord-011302-pfepyvaw 69 34 , , , cord-011302-pfepyvaw 69 35 re re NN cord-011302-pfepyvaw 69 36 - - NN cord-011302-pfepyvaw 69 37 bleeding bleeding JJ cord-011302-pfepyvaw 69 38 , , , cord-011302-pfepyvaw 69 39 and and CC cord-011302-pfepyvaw 69 40 pneumonia pneumonia NN cord-011302-pfepyvaw 69 41 . . . cord-011302-pfepyvaw 70 1 The the DT cord-011302-pfepyvaw 70 2 use use NN cord-011302-pfepyvaw 70 3 of of IN cord-011302-pfepyvaw 70 4 anti anti JJ cord-011302-pfepyvaw 70 5 - - JJ cord-011302-pfepyvaw 70 6 thrombotic thrombotic JJ cord-011302-pfepyvaw 70 7 medications medication NNS cord-011302-pfepyvaw 70 8 at at IN cord-011302-pfepyvaw 70 9 presentation presentation NN cord-011302-pfepyvaw 70 10 is be VBZ cord-011302-pfepyvaw 70 11 also also RB cord-011302-pfepyvaw 70 12 clearly clearly RB cord-011302-pfepyvaw 70 13 a a DT cord-011302-pfepyvaw 70 14 risk risk NN cord-011302-pfepyvaw 70 15 factor factor NN cord-011302-pfepyvaw 70 16 for for IN cord-011302-pfepyvaw 70 17 poor poor JJ cord-011302-pfepyvaw 70 18 outcome outcome NN cord-011302-pfepyvaw 70 19 in in IN cord-011302-pfepyvaw 70 20 all all DT cord-011302-pfepyvaw 70 21 patients patient NNS cord-011302-pfepyvaw 70 22 [ [ -LRB- cord-011302-pfepyvaw 70 23 45 45 CD cord-011302-pfepyvaw 70 24 ] ] -RRB- cord-011302-pfepyvaw 70 25 . . . cord-011302-pfepyvaw 71 1 Another another DT cord-011302-pfepyvaw 71 2 series series NN cord-011302-pfepyvaw 71 3 reported report VBD cord-011302-pfepyvaw 71 4 no no DT cord-011302-pfepyvaw 71 5 survivors survivor NNS cord-011302-pfepyvaw 71 6 in in IN cord-011302-pfepyvaw 71 7 patients patient NNS cord-011302-pfepyvaw 71 8 with with IN cord-011302-pfepyvaw 71 9 an an DT cord-011302-pfepyvaw 71 10 ASDH ASDH NNP cord-011302-pfepyvaw 71 11 aged age VBN cord-011302-pfepyvaw 71 12 over over IN cord-011302-pfepyvaw 71 13 90 90 CD cord-011302-pfepyvaw 71 14 and and CC cord-011302-pfepyvaw 71 15 only only RB cord-011302-pfepyvaw 71 16 one one CD cord-011302-pfepyvaw 71 17 survivor survivor NN cord-011302-pfepyvaw 71 18 out out IN cord-011302-pfepyvaw 71 19 of of IN cord-011302-pfepyvaw 71 20 8 8 CD cord-011302-pfepyvaw 71 21 aged age VBN cord-011302-pfepyvaw 71 22 over over IN cord-011302-pfepyvaw 71 23 65 65 CD cord-011302-pfepyvaw 71 24 presenting present VBG cord-011302-pfepyvaw 71 25 with with IN cord-011302-pfepyvaw 71 26 a a DT cord-011302-pfepyvaw 71 27 GCS GCS NNP cord-011302-pfepyvaw 71 28 of of IN cord-011302-pfepyvaw 71 29 less less JJR cord-011302-pfepyvaw 71 30 than than IN cord-011302-pfepyvaw 71 31 10 10 CD cord-011302-pfepyvaw 71 32 [ [ -LRB- cord-011302-pfepyvaw 71 33 41 41 CD cord-011302-pfepyvaw 71 34 ] ] -RRB- cord-011302-pfepyvaw 71 35 . . . cord-011302-pfepyvaw 72 1 A a DT cord-011302-pfepyvaw 72 2 recent recent JJ cord-011302-pfepyvaw 72 3 systematic systematic JJ cord-011302-pfepyvaw 72 4 review review NN cord-011302-pfepyvaw 72 5 of of IN cord-011302-pfepyvaw 72 6 ASDH ASDH NNP cord-011302-pfepyvaw 72 7 in in IN cord-011302-pfepyvaw 72 8 the the DT cord-011302-pfepyvaw 72 9 elderly elderly JJ cord-011302-pfepyvaw 72 10 reported report VBN cord-011302-pfepyvaw 72 11 on on IN cord-011302-pfepyvaw 72 12 only only RB cord-011302-pfepyvaw 72 13 seven seven CD cord-011302-pfepyvaw 72 14 eligible eligible JJ cord-011302-pfepyvaw 72 15 studies study NNS cord-011302-pfepyvaw 72 16 with with IN cord-011302-pfepyvaw 72 17 the the DT cord-011302-pfepyvaw 72 18 mean mean JJ cord-011302-pfepyvaw 72 19 patient patient JJ cord-011302-pfepyvaw 72 20 age age NN cord-011302-pfepyvaw 72 21 ranging range VBG cord-011302-pfepyvaw 72 22 from from IN cord-011302-pfepyvaw 72 23 73 73 CD cord-011302-pfepyvaw 72 24 to to TO cord-011302-pfepyvaw 72 25 85 85 CD cord-011302-pfepyvaw 72 26 years year NNS cord-011302-pfepyvaw 72 27 [ [ -LRB- cord-011302-pfepyvaw 72 28 10 10 CD cord-011302-pfepyvaw 72 29 ] ] -RRB- cord-011302-pfepyvaw 72 30 . . . cord-011302-pfepyvaw 73 1 Outcomes outcome NNS cord-011302-pfepyvaw 73 2 varied varied JJ cord-011302-pfepyvaw 73 3 with with IN cord-011302-pfepyvaw 73 4 a a DT cord-011302-pfepyvaw 73 5 mortality mortality NN cord-011302-pfepyvaw 73 6 rate rate NN cord-011302-pfepyvaw 73 7 ranging range VBG cord-011302-pfepyvaw 73 8 from from IN cord-011302-pfepyvaw 73 9 27 27 CD cord-011302-pfepyvaw 73 10 to to TO cord-011302-pfepyvaw 73 11 70 70 CD cord-011302-pfepyvaw 73 12 % % NN cord-011302-pfepyvaw 73 13 , , , cord-011302-pfepyvaw 73 14 and and CC cord-011302-pfepyvaw 73 15 a a DT cord-011302-pfepyvaw 73 16 good good JJ cord-011302-pfepyvaw 73 17 functional functional JJ cord-011302-pfepyvaw 73 18 outcome outcome NN cord-011302-pfepyvaw 73 19 in in IN cord-011302-pfepyvaw 73 20 10 10 CD cord-011302-pfepyvaw 73 21 - - SYM cord-011302-pfepyvaw 73 22 41 41 CD cord-011302-pfepyvaw 73 23 % % NN cord-011302-pfepyvaw 73 24 but but CC cord-011302-pfepyvaw 73 25 with with IN cord-011302-pfepyvaw 73 26 a a DT cord-011302-pfepyvaw 73 27 presenting present VBG cord-011302-pfepyvaw 73 28 GCS GCS NNP cord-011302-pfepyvaw 73 29 ≤ ≤ NNP cord-011302-pfepyvaw 73 30 8 8 CD cord-011302-pfepyvaw 73 31 representing represent VBG cord-011302-pfepyvaw 73 32 a a DT cord-011302-pfepyvaw 73 33 poor poor JJ cord-011302-pfepyvaw 73 34 prognostic prognostic JJ cord-011302-pfepyvaw 73 35 factor factor NN cord-011302-pfepyvaw 73 36 . . . cord-011302-pfepyvaw 74 1 However however RB cord-011302-pfepyvaw 74 2 , , , cord-011302-pfepyvaw 74 3 overall overall RB cord-011302-pfepyvaw 74 4 , , , cord-011302-pfepyvaw 74 5 the the DT cord-011302-pfepyvaw 74 6 studies study NNS cord-011302-pfepyvaw 74 7 were be VBD cord-011302-pfepyvaw 74 8 classified classify VBN cord-011302-pfepyvaw 74 9 as as IN cord-011302-pfepyvaw 74 10 low low JJ cord-011302-pfepyvaw 74 11 quality quality NN cord-011302-pfepyvaw 74 12 and and CC cord-011302-pfepyvaw 74 13 were be VBD cord-011302-pfepyvaw 74 14 particularly particularly RB cord-011302-pfepyvaw 74 15 lacking lack VBG cord-011302-pfepyvaw 74 16 in in IN cord-011302-pfepyvaw 74 17 assessments assessment NNS cord-011302-pfepyvaw 74 18 of of IN cord-011302-pfepyvaw 74 19 patient patient NN cord-011302-pfepyvaw 74 20 frailty frailty NN cord-011302-pfepyvaw 74 21 which which WDT cord-011302-pfepyvaw 74 22 may may MD cord-011302-pfepyvaw 74 23 aid aid VB cord-011302-pfepyvaw 74 24 future future JJ cord-011302-pfepyvaw 74 25 research research NN cord-011302-pfepyvaw 74 26 in in IN cord-011302-pfepyvaw 74 27 this this DT cord-011302-pfepyvaw 74 28 field field NN cord-011302-pfepyvaw 74 29 . . . cord-011302-pfepyvaw 75 1 It -PRON- PRP cord-011302-pfepyvaw 75 2 is be VBZ cord-011302-pfepyvaw 75 3 clear clear JJ cord-011302-pfepyvaw 75 4 that that IN cord-011302-pfepyvaw 75 5 poor poor JJ cord-011302-pfepyvaw 75 6 neurology neurology NN cord-011302-pfepyvaw 75 7 from from IN cord-011302-pfepyvaw 75 8 the the DT cord-011302-pfepyvaw 75 9 outset outset NN cord-011302-pfepyvaw 75 10 is be VBZ cord-011302-pfepyvaw 75 11 associated associate VBN cord-011302-pfepyvaw 75 12 with with IN cord-011302-pfepyvaw 75 13 poor poor JJ cord-011302-pfepyvaw 75 14 outcome outcome NN cord-011302-pfepyvaw 75 15 ; ; : cord-011302-pfepyvaw 75 16 however however RB cord-011302-pfepyvaw 75 17 , , , cord-011302-pfepyvaw 75 18 as as IN cord-011302-pfepyvaw 75 19 the the DT cord-011302-pfepyvaw 75 20 incidence incidence NN cord-011302-pfepyvaw 75 21 of of IN cord-011302-pfepyvaw 75 22 this this DT cord-011302-pfepyvaw 75 23 pathology pathology NN cord-011302-pfepyvaw 75 24 appears appear VBZ cord-011302-pfepyvaw 75 25 to to TO cord-011302-pfepyvaw 75 26 be be VB cord-011302-pfepyvaw 75 27 increasing increase VBG cord-011302-pfepyvaw 75 28 in in IN cord-011302-pfepyvaw 75 29 older old JJR cord-011302-pfepyvaw 75 30 patients patient NNS cord-011302-pfepyvaw 75 31 , , , cord-011302-pfepyvaw 75 32 effective effective JJ cord-011302-pfepyvaw 75 33 surgical surgical JJ cord-011302-pfepyvaw 75 34 decision decision NN cord-011302-pfepyvaw 75 35 - - HYPH cord-011302-pfepyvaw 75 36 making make VBG cord-011302-pfepyvaw 75 37 tools tool NNS cord-011302-pfepyvaw 75 38 are be VBP cord-011302-pfepyvaw 75 39 needed need VBN cord-011302-pfepyvaw 75 40 . . . cord-011302-pfepyvaw 76 1 In in IN cord-011302-pfepyvaw 76 2 patients patient NNS cord-011302-pfepyvaw 76 3 over over IN cord-011302-pfepyvaw 76 4 80 80 CD cord-011302-pfepyvaw 76 5 years year NNS cord-011302-pfepyvaw 76 6 old old JJ cord-011302-pfepyvaw 76 7 , , , cord-011302-pfepyvaw 76 8 with with IN cord-011302-pfepyvaw 76 9 multi multi JJ cord-011302-pfepyvaw 76 10 - - JJ cord-011302-pfepyvaw 76 11 morbidity morbidity JJ cord-011302-pfepyvaw 76 12 and and CC cord-011302-pfepyvaw 76 13 poor poor JJ cord-011302-pfepyvaw 76 14 neurology neurology NN cord-011302-pfepyvaw 76 15 , , , cord-011302-pfepyvaw 76 16 caution caution NN cord-011302-pfepyvaw 76 17 should should MD cord-011302-pfepyvaw 76 18 be be VB cord-011302-pfepyvaw 76 19 applied apply VBN cord-011302-pfepyvaw 76 20 ; ; : cord-011302-pfepyvaw 76 21 however however RB cord-011302-pfepyvaw 76 22 , , , cord-011302-pfepyvaw 76 23 it -PRON- PRP cord-011302-pfepyvaw 76 24 could could MD cord-011302-pfepyvaw 76 25 be be VB cord-011302-pfepyvaw 76 26 advocated advocate VBN cord-011302-pfepyvaw 76 27 that that IN cord-011302-pfepyvaw 76 28 in in IN cord-011302-pfepyvaw 76 29 all all DT cord-011302-pfepyvaw 76 30 other other JJ cord-011302-pfepyvaw 76 31 circumstances circumstance NNS cord-011302-pfepyvaw 76 32 surgical surgical JJ cord-011302-pfepyvaw 76 33 treatment treatment NN cord-011302-pfepyvaw 76 34 should should MD cord-011302-pfepyvaw 76 35 at at IN cord-011302-pfepyvaw 76 36 least least JJS cord-011302-pfepyvaw 76 37 be be VB cord-011302-pfepyvaw 76 38 considered consider VBN cord-011302-pfepyvaw 76 39 . . . cord-011302-pfepyvaw 77 1 Attempts attempt NNS cord-011302-pfepyvaw 77 2 have have VBP cord-011302-pfepyvaw 77 3 been be VBN cord-011302-pfepyvaw 77 4 made make VBN cord-011302-pfepyvaw 77 5 at at IN cord-011302-pfepyvaw 77 6 producing produce VBG cord-011302-pfepyvaw 77 7 scoring score VBG cord-011302-pfepyvaw 77 8 systems system NNS cord-011302-pfepyvaw 77 9 to to TO cord-011302-pfepyvaw 77 10 aid aid VB cord-011302-pfepyvaw 77 11 prognostication prognostication NN cord-011302-pfepyvaw 77 12 in in IN cord-011302-pfepyvaw 77 13 elderly elderly JJ cord-011302-pfepyvaw 77 14 patients patient NNS cord-011302-pfepyvaw 77 15 with with IN cord-011302-pfepyvaw 77 16 ASDH ASDH NNP cord-011302-pfepyvaw 77 17 , , , cord-011302-pfepyvaw 77 18 but but CC cord-011302-pfepyvaw 77 19 more more RBR cord-011302-pfepyvaw 77 20 widespread widespread JJ cord-011302-pfepyvaw 77 21 validation validation NN cord-011302-pfepyvaw 77 22 of of IN cord-011302-pfepyvaw 77 23 this this DT cord-011302-pfepyvaw 77 24 is be VBZ cord-011302-pfepyvaw 77 25 required require VBN cord-011302-pfepyvaw 77 26 [ [ -LRB- cord-011302-pfepyvaw 77 27 1 1 CD cord-011302-pfepyvaw 77 28 ] ] -RRB- cord-011302-pfepyvaw 77 29 . . . cord-011302-pfepyvaw 78 1 It -PRON- PRP cord-011302-pfepyvaw 78 2 is be VBZ cord-011302-pfepyvaw 78 3 notable notable JJ cord-011302-pfepyvaw 78 4 that that IN cord-011302-pfepyvaw 78 5 several several JJ cord-011302-pfepyvaw 78 6 large large JJ cord-011302-pfepyvaw 78 7 - - HYPH cord-011302-pfepyvaw 78 8 scale scale NN cord-011302-pfepyvaw 78 9 studies study NNS cord-011302-pfepyvaw 78 10 assessing assess VBG cord-011302-pfepyvaw 78 11 interventions intervention NNS cord-011302-pfepyvaw 78 12 for for IN cord-011302-pfepyvaw 78 13 severe severe JJ cord-011302-pfepyvaw 78 14 traumatic traumatic JJ cord-011302-pfepyvaw 78 15 brain brain NN cord-011302-pfepyvaw 78 16 injury injury NN cord-011302-pfepyvaw 78 17 ( ( -LRB- cord-011302-pfepyvaw 78 18 TBI TBI NNP cord-011302-pfepyvaw 78 19 ) ) -RRB- cord-011302-pfepyvaw 78 20 in in IN cord-011302-pfepyvaw 78 21 general general JJ cord-011302-pfepyvaw 78 22 , , , cord-011302-pfepyvaw 78 23 including include VBG cord-011302-pfepyvaw 78 24 decompressive decompressive JJ cord-011302-pfepyvaw 78 25 craniectomy craniectomy NNP cord-011302-pfepyvaw 78 26 [ [ -LRB- cord-011302-pfepyvaw 78 27 7 7 CD cord-011302-pfepyvaw 78 28 , , , cord-011302-pfepyvaw 78 29 16 16 CD cord-011302-pfepyvaw 78 30 ] ] -RRB- cord-011302-pfepyvaw 78 31 , , , cord-011302-pfepyvaw 78 32 ICP ICP NNP cord-011302-pfepyvaw 78 33 monitoring monitor VBG cord-011302-pfepyvaw 78 34 [ [ -LRB- cord-011302-pfepyvaw 78 35 5 5 CD cord-011302-pfepyvaw 78 36 ] ] -RRB- cord-011302-pfepyvaw 78 37 , , , cord-011302-pfepyvaw 78 38 and and CC cord-011302-pfepyvaw 78 39 cooling cool VBG cord-011302-pfepyvaw 78 40 [ [ -LRB- cord-011302-pfepyvaw 78 41 2 2 CD cord-011302-pfepyvaw 78 42 ] ] -RRB- cord-011302-pfepyvaw 78 43 , , , cord-011302-pfepyvaw 78 44 have have VBP cord-011302-pfepyvaw 78 45 either either CC cord-011302-pfepyvaw 78 46 excluded exclude VBN cord-011302-pfepyvaw 78 47 older old JJR cord-011302-pfepyvaw 78 48 patients patient NNS cord-011302-pfepyvaw 78 49 or or CC cord-011302-pfepyvaw 78 50 had have VBD cord-011302-pfepyvaw 78 51 minimal minimal JJ cord-011302-pfepyvaw 78 52 numbers number NNS cord-011302-pfepyvaw 78 53 of of IN cord-011302-pfepyvaw 78 54 them -PRON- PRP cord-011302-pfepyvaw 78 55 . . . cord-011302-pfepyvaw 79 1 Whilst whilst IN cord-011302-pfepyvaw 79 2 this this DT cord-011302-pfepyvaw 79 3 makes make VBZ cord-011302-pfepyvaw 79 4 understanding understanding NN cord-011302-pfepyvaw 79 5 treatment treatment NN cord-011302-pfepyvaw 79 6 in in IN cord-011302-pfepyvaw 79 7 this this DT cord-011302-pfepyvaw 79 8 age age NN cord-011302-pfepyvaw 79 9 group group NN cord-011302-pfepyvaw 79 10 challenging challenge VBG cord-011302-pfepyvaw 79 11 , , , cord-011302-pfepyvaw 79 12 it -PRON- PRP cord-011302-pfepyvaw 79 13 may may MD cord-011302-pfepyvaw 79 14 also also RB cord-011302-pfepyvaw 79 15 just just RB cord-011302-pfepyvaw 79 16 be be VB cord-011302-pfepyvaw 79 17 a a DT cord-011302-pfepyvaw 79 18 reflection reflection NN cord-011302-pfepyvaw 79 19 of of IN cord-011302-pfepyvaw 79 20 the the DT cord-011302-pfepyvaw 79 21 reality reality NN cord-011302-pfepyvaw 79 22 that that IN cord-011302-pfepyvaw 79 23 fewer few JJR cord-011302-pfepyvaw 79 24 older old JJR cord-011302-pfepyvaw 79 25 patients patient NNS cord-011302-pfepyvaw 79 26 are be VBP cord-011302-pfepyvaw 79 27 considered consider VBN cord-011302-pfepyvaw 79 28 likely likely JJ cord-011302-pfepyvaw 79 29 to to TO cord-011302-pfepyvaw 79 30 survive survive VB cord-011302-pfepyvaw 79 31 intervention intervention NN cord-011302-pfepyvaw 79 32 . . . cord-011302-pfepyvaw 80 1 This this DT cord-011302-pfepyvaw 80 2 is be VBZ cord-011302-pfepyvaw 80 3 supported support VBN cord-011302-pfepyvaw 80 4 by by IN cord-011302-pfepyvaw 80 5 collaborations collaboration NNS cord-011302-pfepyvaw 80 6 such such JJ cord-011302-pfepyvaw 80 7 as as IN cord-011302-pfepyvaw 80 8 IMPACT IMPACT NNP cord-011302-pfepyvaw 80 9 ( ( -LRB- cord-011302-pfepyvaw 80 10 International International NNP cord-011302-pfepyvaw 80 11 Mission Mission NNP cord-011302-pfepyvaw 80 12 for for IN cord-011302-pfepyvaw 80 13 Prognosis Prognosis NNP cord-011302-pfepyvaw 80 14 and and CC cord-011302-pfepyvaw 80 15 Analysis Analysis NNP cord-011302-pfepyvaw 80 16 of of IN cord-011302-pfepyvaw 80 17 Clinical Clinical NNP cord-011302-pfepyvaw 80 18 Trials Trials NNPS cord-011302-pfepyvaw 80 19 in in IN cord-011302-pfepyvaw 80 20 TBI TBI NNP cord-011302-pfepyvaw 80 21 ) ) -RRB- cord-011302-pfepyvaw 80 22 and and CC cord-011302-pfepyvaw 80 23 CRASH crash NN cord-011302-pfepyvaw 80 24 ( ( -LRB- cord-011302-pfepyvaw 80 25 Corticosteroid Corticosteroid NNP cord-011302-pfepyvaw 80 26 Randomisation Randomisation NNP cord-011302-pfepyvaw 81 1 After after IN cord-011302-pfepyvaw 81 2 Significant significant JJ cord-011302-pfepyvaw 81 3 Head Head NNP cord-011302-pfepyvaw 81 4 injury injury NN cord-011302-pfepyvaw 81 5 ) ) -RRB- cord-011302-pfepyvaw 81 6 , , , cord-011302-pfepyvaw 81 7 who who WP cord-011302-pfepyvaw 81 8 have have VBP cord-011302-pfepyvaw 81 9 used use VBN cord-011302-pfepyvaw 81 10 available available JJ cord-011302-pfepyvaw 81 11 evidence evidence NN cord-011302-pfepyvaw 81 12 to to TO cord-011302-pfepyvaw 81 13 develop develop VB cord-011302-pfepyvaw 81 14 prognostic prognostic JJ cord-011302-pfepyvaw 81 15 calculators calculator NNS cord-011302-pfepyvaw 81 16 for for IN cord-011302-pfepyvaw 81 17 TBI TBI NNP cord-011302-pfepyvaw 81 18 , , , cord-011302-pfepyvaw 81 19 where where WRB cord-011302-pfepyvaw 81 20 age age NN cord-011302-pfepyvaw 81 21 is be VBZ cord-011302-pfepyvaw 81 22 a a DT cord-011302-pfepyvaw 81 23 corestratifying corestratifye VBG cord-011302-pfepyvaw 81 24 component component NN cord-011302-pfepyvaw 81 25 and and CC cord-011302-pfepyvaw 81 26 significantly significantly RB cord-011302-pfepyvaw 81 27 increases increase VBZ cord-011302-pfepyvaw 81 28 chances chance NNS cord-011302-pfepyvaw 81 29 of of IN cord-011302-pfepyvaw 81 30 a a DT cord-011302-pfepyvaw 81 31 poor poor JJ cord-011302-pfepyvaw 81 32 outcome outcome NN cord-011302-pfepyvaw 81 33 [ [ -LRB- cord-011302-pfepyvaw 81 34 17 17 CD cord-011302-pfepyvaw 81 35 , , , cord-011302-pfepyvaw 81 36 38 38 CD cord-011302-pfepyvaw 81 37 ] ] -RRB- cord-011302-pfepyvaw 81 38 . . . cord-011302-pfepyvaw 82 1 Overall overall RB cord-011302-pfepyvaw 82 2 , , , cord-011302-pfepyvaw 82 3 it -PRON- PRP cord-011302-pfepyvaw 82 4 is be VBZ cord-011302-pfepyvaw 82 5 recognised recognise VBN cord-011302-pfepyvaw 82 6 that that IN cord-011302-pfepyvaw 82 7 a a DT cord-011302-pfepyvaw 82 8 lack lack NN cord-011302-pfepyvaw 82 9 of of IN cord-011302-pfepyvaw 82 10 evidence evidence NN cord-011302-pfepyvaw 82 11 has have VBZ cord-011302-pfepyvaw 82 12 led lead VBN cord-011302-pfepyvaw 82 13 to to IN cord-011302-pfepyvaw 82 14 varying vary VBG cord-011302-pfepyvaw 82 15 practices practice NNS cord-011302-pfepyvaw 82 16 and and CC cord-011302-pfepyvaw 82 17 understanding understanding NN cord-011302-pfepyvaw 82 18 about about IN cord-011302-pfepyvaw 82 19 interventions intervention NNS cord-011302-pfepyvaw 82 20 for for IN cord-011302-pfepyvaw 82 21 TBI TBI NNP cord-011302-pfepyvaw 82 22 in in IN cord-011302-pfepyvaw 82 23 older old JJR cord-011302-pfepyvaw 82 24 patients patient NNS cord-011302-pfepyvaw 82 25 , , , cord-011302-pfepyvaw 82 26 but but CC cord-011302-pfepyvaw 82 27 it -PRON- PRP cord-011302-pfepyvaw 82 28 is be VBZ cord-011302-pfepyvaw 82 29 clear clear JJ cord-011302-pfepyvaw 82 30 that that IN cord-011302-pfepyvaw 82 31 functional functional JJ cord-011302-pfepyvaw 82 32 and and CC cord-011302-pfepyvaw 82 33 cognitive cognitive JJ cord-011302-pfepyvaw 82 34 recovery recovery NN cord-011302-pfepyvaw 82 35 is be VBZ cord-011302-pfepyvaw 82 36 significantly significantly RB cord-011302-pfepyvaw 82 37 worse bad JJR cord-011302-pfepyvaw 82 38 in in IN cord-011302-pfepyvaw 82 39 this this DT cord-011302-pfepyvaw 82 40 age age NN cord-011302-pfepyvaw 82 41 group group NN cord-011302-pfepyvaw 82 42 [ [ -LRB- cord-011302-pfepyvaw 82 43 13 13 CD cord-011302-pfepyvaw 82 44 ] ] -RRB- cord-011302-pfepyvaw 82 45 . . . cord-011302-pfepyvaw 83 1 Understanding understand VBG cord-011302-pfepyvaw 83 2 patient patient JJ cord-011302-pfepyvaw 83 3 baseline baseline JJ cord-011302-pfepyvaw 83 4 function function NN cord-011302-pfepyvaw 83 5 and and CC cord-011302-pfepyvaw 83 6 morbidity morbidity NN cord-011302-pfepyvaw 83 7 is be VBZ cord-011302-pfepyvaw 83 8 important important JJ cord-011302-pfepyvaw 83 9 , , , cord-011302-pfepyvaw 83 10 but but CC cord-011302-pfepyvaw 83 11 recognising recognise VBG cord-011302-pfepyvaw 83 12 the the DT cord-011302-pfepyvaw 83 13 high high JJ cord-011302-pfepyvaw 83 14 chance chance NN cord-011302-pfepyvaw 83 15 of of IN cord-011302-pfepyvaw 83 16 a a DT cord-011302-pfepyvaw 83 17 poor poor JJ cord-011302-pfepyvaw 83 18 outcome outcome NN cord-011302-pfepyvaw 83 19 in in IN cord-011302-pfepyvaw 83 20 this this DT cord-011302-pfepyvaw 83 21 age age NN cord-011302-pfepyvaw 83 22 group group NN cord-011302-pfepyvaw 83 23 often often RB cord-011302-pfepyvaw 83 24 leads lead VBZ cord-011302-pfepyvaw 83 25 clinicians clinician NNS cord-011302-pfepyvaw 83 26 to to TO cord-011302-pfepyvaw 83 27 follow follow VB cord-011302-pfepyvaw 83 28 a a DT cord-011302-pfepyvaw 83 29 conservative conservative JJ cord-011302-pfepyvaw 83 30 route route NN cord-011302-pfepyvaw 83 31 , , , cord-011302-pfepyvaw 83 32 avoiding avoid VBG cord-011302-pfepyvaw 83 33 neurointensive neurointensive JJ cord-011302-pfepyvaw 83 34 care care NN cord-011302-pfepyvaw 83 35 . . . cord-011302-pfepyvaw 84 1 Intracranial intracranial JJ cord-011302-pfepyvaw 84 2 haemorrhage haemorrhage NN cord-011302-pfepyvaw 84 3 ( ( -LRB- cord-011302-pfepyvaw 84 4 ICH ICH NNP cord-011302-pfepyvaw 84 5 ) ) -RRB- cord-011302-pfepyvaw 84 6 in in IN cord-011302-pfepyvaw 84 7 older old JJR cord-011302-pfepyvaw 84 8 people people NNS cord-011302-pfepyvaw 84 9 is be VBZ cord-011302-pfepyvaw 84 10 often often RB cord-011302-pfepyvaw 84 11 the the DT cord-011302-pfepyvaw 84 12 result result NN cord-011302-pfepyvaw 84 13 of of IN cord-011302-pfepyvaw 84 14 long long RB cord-011302-pfepyvaw 84 15 - - HYPH cord-011302-pfepyvaw 84 16 standing stand VBG cord-011302-pfepyvaw 84 17 underlying underlying JJ cord-011302-pfepyvaw 84 18 pathological pathological JJ cord-011302-pfepyvaw 84 19 vascular vascular JJ cord-011302-pfepyvaw 84 20 disease disease NN cord-011302-pfepyvaw 84 21 . . . cord-011302-pfepyvaw 85 1 A a DT cord-011302-pfepyvaw 85 2 patient patient NN cord-011302-pfepyvaw 85 3 , , , cord-011302-pfepyvaw 85 4 therefore therefore RB cord-011302-pfepyvaw 85 5 , , , cord-011302-pfepyvaw 85 6 has have VBZ cord-011302-pfepyvaw 85 7 the the DT cord-011302-pfepyvaw 85 8 intracranial intracranial JJ cord-011302-pfepyvaw 85 9 pressure pressure NN cord-011302-pfepyvaw 85 10 effects effect NNS cord-011302-pfepyvaw 85 11 and and CC cord-011302-pfepyvaw 85 12 focal focal JJ cord-011302-pfepyvaw 85 13 neurological neurological JJ cord-011302-pfepyvaw 85 14 deficits deficit NNS cord-011302-pfepyvaw 85 15 associated associate VBN cord-011302-pfepyvaw 85 16 with with IN cord-011302-pfepyvaw 85 17 the the DT cord-011302-pfepyvaw 85 18 ICH ICH NNP cord-011302-pfepyvaw 85 19 in in IN cord-011302-pfepyvaw 85 20 addition addition NN cord-011302-pfepyvaw 85 21 to to IN cord-011302-pfepyvaw 85 22 the the DT cord-011302-pfepyvaw 85 23 systemic systemic JJ cord-011302-pfepyvaw 85 24 co co NNS cord-011302-pfepyvaw 85 25 - - NNS cord-011302-pfepyvaw 85 26 morbidities morbidity NNS cord-011302-pfepyvaw 85 27 of of IN cord-011302-pfepyvaw 85 28 cardiac cardiac JJ cord-011302-pfepyvaw 85 29 , , , cord-011302-pfepyvaw 85 30 peripheral peripheral JJ cord-011302-pfepyvaw 85 31 vascular vascular JJ cord-011302-pfepyvaw 85 32 disease disease NN cord-011302-pfepyvaw 85 33 , , , cord-011302-pfepyvaw 85 34 and and CC cord-011302-pfepyvaw 85 35 often often RB cord-011302-pfepyvaw 85 36 anti anti JJ cord-011302-pfepyvaw 85 37 - - JJ cord-011302-pfepyvaw 85 38 thrombotic thrombotic JJ cord-011302-pfepyvaw 85 39 medication medication NN cord-011302-pfepyvaw 85 40 use use NN cord-011302-pfepyvaw 85 41 . . . cord-011302-pfepyvaw 86 1 Furthermore furthermore RB cord-011302-pfepyvaw 86 2 , , , cord-011302-pfepyvaw 86 3 secondary secondary JJ cord-011302-pfepyvaw 86 4 haemorrhage haemorrhage NN cord-011302-pfepyvaw 86 5 is be VBZ cord-011302-pfepyvaw 86 6 always always RB cord-011302-pfepyvaw 86 7 a a DT cord-011302-pfepyvaw 86 8 concern concern NN cord-011302-pfepyvaw 86 9 . . . cord-011302-pfepyvaw 87 1 The the DT cord-011302-pfepyvaw 87 2 STICH STICH NNP cord-011302-pfepyvaw 87 3 I I NNP cord-011302-pfepyvaw 87 4 and and CC cord-011302-pfepyvaw 87 5 II II NNP cord-011302-pfepyvaw 87 6 trials trial NNS cord-011302-pfepyvaw 87 7 did do VBD cord-011302-pfepyvaw 87 8 not not RB cord-011302-pfepyvaw 87 9 demonstrate demonstrate VB cord-011302-pfepyvaw 87 10 any any DT cord-011302-pfepyvaw 87 11 overall overall JJ cord-011302-pfepyvaw 87 12 benefit benefit NN cord-011302-pfepyvaw 87 13 from from IN cord-011302-pfepyvaw 87 14 early early JJ cord-011302-pfepyvaw 87 15 surgery surgery NN cord-011302-pfepyvaw 87 16 compared compare VBN cord-011302-pfepyvaw 87 17 with with IN cord-011302-pfepyvaw 87 18 initial initial JJ cord-011302-pfepyvaw 87 19 conservative conservative JJ cord-011302-pfepyvaw 87 20 management management NN cord-011302-pfepyvaw 87 21 for for IN cord-011302-pfepyvaw 87 22 supratentorial supratentorial NNP cord-011302-pfepyvaw 87 23 ( ( -LRB- cord-011302-pfepyvaw 87 24 including include VBG cord-011302-pfepyvaw 87 25 lobar lobar NNP cord-011302-pfepyvaw 87 26 ) ) -RRB- cord-011302-pfepyvaw 87 27 ICH ICH NNP cord-011302-pfepyvaw 87 28 . . . cord-011302-pfepyvaw 88 1 [ [ -LRB- cord-011302-pfepyvaw 88 2 22 22 CD cord-011302-pfepyvaw 88 3 , , , cord-011302-pfepyvaw 88 4 23 23 CD cord-011302-pfepyvaw 88 5 ] ] -RRB- cord-011302-pfepyvaw 88 6 . . . cord-011302-pfepyvaw 89 1 The the DT cord-011302-pfepyvaw 89 2 median median JJ cord-011302-pfepyvaw 89 3 patient patient NN cord-011302-pfepyvaw 89 4 age age NN cord-011302-pfepyvaw 89 5 for for IN cord-011302-pfepyvaw 89 6 STICH STICH NNP cord-011302-pfepyvaw 90 1 I -PRON- PRP cord-011302-pfepyvaw 90 2 was be VBD cord-011302-pfepyvaw 90 3 62 62 CD cord-011302-pfepyvaw 90 4 years year NNS cord-011302-pfepyvaw 91 1 ( ( -LRB- cord-011302-pfepyvaw 91 2 IQR IQR NNP cord-011302-pfepyvaw 91 3 52 52 CD cord-011302-pfepyvaw 91 4 - - SYM cord-011302-pfepyvaw 91 5 70 70 CD cord-011302-pfepyvaw 91 6 ) ) -RRB- cord-011302-pfepyvaw 91 7 and and CC cord-011302-pfepyvaw 91 8 65 65 CD cord-011302-pfepyvaw 91 9 years year NNS cord-011302-pfepyvaw 92 1 ( ( -LRB- cord-011302-pfepyvaw 92 2 IQR IQR NNP cord-011302-pfepyvaw 92 3 55 55 CD cord-011302-pfepyvaw 92 4 - - SYM cord-011302-pfepyvaw 92 5 74 74 CD cord-011302-pfepyvaw 92 6 ) ) -RRB- cord-011302-pfepyvaw 92 7 for for IN cord-011302-pfepyvaw 92 8 STICH STICH NNP cord-011302-pfepyvaw 92 9 II II NNP cord-011302-pfepyvaw 92 10 . . . cord-011302-pfepyvaw 93 1 The the DT cord-011302-pfepyvaw 93 2 inference inference NN cord-011302-pfepyvaw 93 3 from from IN cord-011302-pfepyvaw 93 4 these these DT cord-011302-pfepyvaw 93 5 studies study NNS cord-011302-pfepyvaw 93 6 is be VBZ cord-011302-pfepyvaw 93 7 that that IN cord-011302-pfepyvaw 93 8 surgeons surgeon NNS cord-011302-pfepyvaw 93 9 are be VBP cord-011302-pfepyvaw 93 10 already already RB cord-011302-pfepyvaw 93 11 appropriately appropriately RB cord-011302-pfepyvaw 93 12 undertaking undertake VBG cord-011302-pfepyvaw 93 13 selective selective JJ cord-011302-pfepyvaw 93 14 , , , cord-011302-pfepyvaw 93 15 targeted target VBN cord-011302-pfepyvaw 93 16 surgery surgery NN cord-011302-pfepyvaw 93 17 to to IN cord-011302-pfepyvaw 93 18 the the DT cord-011302-pfepyvaw 93 19 patients patient NNS cord-011302-pfepyvaw 93 20 that that WDT cord-011302-pfepyvaw 93 21 are be VBP cord-011302-pfepyvaw 93 22 most most RBS cord-011302-pfepyvaw 93 23 likely likely JJ cord-011302-pfepyvaw 93 24 to to TO cord-011302-pfepyvaw 93 25 benefit benefit VB cord-011302-pfepyvaw 93 26 from from IN cord-011302-pfepyvaw 93 27 it -PRON- PRP cord-011302-pfepyvaw 93 28 . . . cord-011302-pfepyvaw 94 1 When when WRB cord-011302-pfepyvaw 94 2 there there EX cord-011302-pfepyvaw 94 3 is be VBZ cord-011302-pfepyvaw 94 4 equipoise equipoise NN cord-011302-pfepyvaw 94 5 about about IN cord-011302-pfepyvaw 94 6 whether whether IN cord-011302-pfepyvaw 94 7 to to TO cord-011302-pfepyvaw 94 8 operate operate VB cord-011302-pfepyvaw 94 9 , , , cord-011302-pfepyvaw 94 10 these these DT cord-011302-pfepyvaw 94 11 studies study NNS cord-011302-pfepyvaw 94 12 suggest suggest VBP cord-011302-pfepyvaw 94 13 that that IN cord-011302-pfepyvaw 94 14 it -PRON- PRP cord-011302-pfepyvaw 94 15 is be VBZ cord-011302-pfepyvaw 94 16 reasonable reasonable JJ cord-011302-pfepyvaw 94 17 to to TO cord-011302-pfepyvaw 94 18 manage manage VB cord-011302-pfepyvaw 94 19 the the DT cord-011302-pfepyvaw 94 20 patient patient NN cord-011302-pfepyvaw 94 21 conservatively conservatively RB cord-011302-pfepyvaw 94 22 in in IN cord-011302-pfepyvaw 94 23 the the DT cord-011302-pfepyvaw 94 24 first first JJ cord-011302-pfepyvaw 94 25 instance instance NN cord-011302-pfepyvaw 94 26 and and CC cord-011302-pfepyvaw 94 27 then then RB cord-011302-pfepyvaw 94 28 re re VB cord-011302-pfepyvaw 94 29 - - VB cord-011302-pfepyvaw 94 30 assess assess VB cord-011302-pfepyvaw 94 31 . . . cord-011302-pfepyvaw 95 1 More more RBR cord-011302-pfepyvaw 95 2 recently recently RB cord-011302-pfepyvaw 95 3 , , , cord-011302-pfepyvaw 95 4 there there EX cord-011302-pfepyvaw 95 5 has have VBZ cord-011302-pfepyvaw 95 6 been be VBN cord-011302-pfepyvaw 95 7 a a DT cord-011302-pfepyvaw 95 8 move move NN cord-011302-pfepyvaw 95 9 towards towards IN cord-011302-pfepyvaw 95 10 minimallyinvasive minimallyinvasive JJ cord-011302-pfepyvaw 95 11 surgery surgery NN cord-011302-pfepyvaw 95 12 ( ( -LRB- cord-011302-pfepyvaw 95 13 MIS MIS NNP cord-011302-pfepyvaw 95 14 ) ) -RRB- cord-011302-pfepyvaw 95 15 for for IN cord-011302-pfepyvaw 95 16 ICH ICH NNP cord-011302-pfepyvaw 95 17 , , , cord-011302-pfepyvaw 95 18 with with IN cord-011302-pfepyvaw 95 19 the the DT cord-011302-pfepyvaw 95 20 potential potential JJ cord-011302-pfepyvaw 95 21 benefits benefit NNS cord-011302-pfepyvaw 95 22 of of IN cord-011302-pfepyvaw 95 23 being be VBG cord-011302-pfepyvaw 95 24 less less RBR cord-011302-pfepyvaw 95 25 traumatic traumatic JJ cord-011302-pfepyvaw 95 26 , , , cord-011302-pfepyvaw 95 27 quicker quick RBR cord-011302-pfepyvaw 95 28 , , , cord-011302-pfepyvaw 95 29 and and CC cord-011302-pfepyvaw 95 30 more more RBR cord-011302-pfepyvaw 95 31 focused focused JJ cord-011302-pfepyvaw 95 32 than than IN cord-011302-pfepyvaw 95 33 a a DT cord-011302-pfepyvaw 95 34 craniotomy craniotomy NN cord-011302-pfepyvaw 95 35 . . . cord-011302-pfepyvaw 96 1 However however RB cord-011302-pfepyvaw 96 2 , , , cord-011302-pfepyvaw 96 3 controversy controversy NN cord-011302-pfepyvaw 96 4 exists exist VBZ cord-011302-pfepyvaw 96 5 concerning concern VBG cord-011302-pfepyvaw 96 6 the the DT cord-011302-pfepyvaw 96 7 widespread widespread JJ cord-011302-pfepyvaw 96 8 clinical clinical JJ cord-011302-pfepyvaw 96 9 application application NN cord-011302-pfepyvaw 96 10 of of IN cord-011302-pfepyvaw 96 11 such such JJ cord-011302-pfepyvaw 96 12 techniques technique NNS cord-011302-pfepyvaw 96 13 . . . cord-011302-pfepyvaw 97 1 A a DT cord-011302-pfepyvaw 97 2 recent recent JJ cord-011302-pfepyvaw 97 3 meta meta JJ cord-011302-pfepyvaw 97 4 - - HYPH cord-011302-pfepyvaw 97 5 analysis analysis NN cord-011302-pfepyvaw 97 6 ( ( -LRB- cord-011302-pfepyvaw 97 7 2018 2018 CD cord-011302-pfepyvaw 97 8 ) ) -RRB- cord-011302-pfepyvaw 97 9 on on IN cord-011302-pfepyvaw 97 10 MIS MIS NNP cord-011302-pfepyvaw 97 11 for for IN cord-011302-pfepyvaw 97 12 hypertensive hypertensive JJ cord-011302-pfepyvaw 97 13 ICH ICH NNP cord-011302-pfepyvaw 97 14 ( ( -LRB- cord-011302-pfepyvaw 97 15 the the DT cord-011302-pfepyvaw 97 16 most most RBS cord-011302-pfepyvaw 97 17 common common JJ cord-011302-pfepyvaw 97 18 cause cause NN cord-011302-pfepyvaw 97 19 of of IN cord-011302-pfepyvaw 97 20 spontaneous spontaneous JJ cord-011302-pfepyvaw 97 21 ICH ICH NNP cord-011302-pfepyvaw 97 22 ) ) -RRB- cord-011302-pfepyvaw 97 23 , , , cord-011302-pfepyvaw 97 24 reported report VBD cord-011302-pfepyvaw 97 25 a a DT cord-011302-pfepyvaw 97 26 positive positive JJ cord-011302-pfepyvaw 97 27 effect effect NN cord-011302-pfepyvaw 97 28 on on IN cord-011302-pfepyvaw 97 29 patient patient JJ cord-011302-pfepyvaw 97 30 prognosis prognosis NN cord-011302-pfepyvaw 97 31 ( ( -LRB- cord-011302-pfepyvaw 97 32 using use VBG cord-011302-pfepyvaw 97 33 GOS GOS NNP cord-011302-pfepyvaw 97 34 ) ) -RRB- cord-011302-pfepyvaw 97 35 compared compare VBN cord-011302-pfepyvaw 97 36 to to IN cord-011302-pfepyvaw 97 37 both both CC cord-011302-pfepyvaw 97 38 craniotomy craniotomy NN cord-011302-pfepyvaw 97 39 and and CC cord-011302-pfepyvaw 97 40 conservative conservative JJ cord-011302-pfepyvaw 97 41 treatment treatment NN cord-011302-pfepyvaw 97 42 [ [ -LRB- cord-011302-pfepyvaw 97 43 37 37 CD cord-011302-pfepyvaw 97 44 ] ] -RRB- cord-011302-pfepyvaw 97 45 . . . cord-011302-pfepyvaw 98 1 Mortality mortality NN cord-011302-pfepyvaw 98 2 rates rate NNS cord-011302-pfepyvaw 98 3 were be VBD cord-011302-pfepyvaw 98 4 lower low JJR cord-011302-pfepyvaw 98 5 for for IN cord-011302-pfepyvaw 98 6 MIS mi NNS cord-011302-pfepyvaw 98 7 compared compare VBN cord-011302-pfepyvaw 98 8 to to IN cord-011302-pfepyvaw 98 9 conservative conservative JJ cord-011302-pfepyvaw 98 10 treatment treatment NN cord-011302-pfepyvaw 98 11 and and CC cord-011302-pfepyvaw 98 12 post post JJ cord-011302-pfepyvaw 98 13 - - JJ cord-011302-pfepyvaw 98 14 operative operative JJ cord-011302-pfepyvaw 98 15 re re NN cord-011302-pfepyvaw 98 16 - - JJ cord-011302-pfepyvaw 98 17 bleeding bleeding JJ cord-011302-pfepyvaw 98 18 rates rate NNS cord-011302-pfepyvaw 98 19 were be VBD cord-011302-pfepyvaw 98 20 lower low JJR cord-011302-pfepyvaw 98 21 for for IN cord-011302-pfepyvaw 98 22 MIS mi NNS cord-011302-pfepyvaw 98 23 compared compare VBN cord-011302-pfepyvaw 98 24 to to IN cord-011302-pfepyvaw 98 25 craniotomy craniotomy NN cord-011302-pfepyvaw 98 26 . . . cord-011302-pfepyvaw 99 1 As as IN cord-011302-pfepyvaw 99 2 this this DT cord-011302-pfepyvaw 99 3 review review NN cord-011302-pfepyvaw 99 4 only only RB cord-011302-pfepyvaw 99 5 included include VBD cord-011302-pfepyvaw 99 6 eight eight CD cord-011302-pfepyvaw 99 7 randomised randomised JJ cord-011302-pfepyvaw 99 8 controlled control VBN cord-011302-pfepyvaw 99 9 trials trial NNS cord-011302-pfepyvaw 99 10 and and CC cord-011302-pfepyvaw 99 11 most most JJS cord-011302-pfepyvaw 99 12 studies study NNS cord-011302-pfepyvaw 99 13 also also RB cord-011302-pfepyvaw 99 14 excluded exclude VBD cord-011302-pfepyvaw 99 15 patients patient NNS cord-011302-pfepyvaw 99 16 that that WDT cord-011302-pfepyvaw 99 17 were be VBD cord-011302-pfepyvaw 99 18 > > NNS cord-011302-pfepyvaw 99 19 80 80 CD cord-011302-pfepyvaw 99 20 years year NNS cord-011302-pfepyvaw 99 21 old old JJ cord-011302-pfepyvaw 99 22 , , , cord-011302-pfepyvaw 99 23 more more RBR cord-011302-pfepyvaw 99 24 high high JJ cord-011302-pfepyvaw 99 25 - - HYPH cord-011302-pfepyvaw 99 26 quality quality NN cord-011302-pfepyvaw 99 27 studies study NNS cord-011302-pfepyvaw 99 28 and and CC cord-011302-pfepyvaw 99 29 in in IN cord-011302-pfepyvaw 99 30 a a DT cord-011302-pfepyvaw 99 31 wider wide JJR cord-011302-pfepyvaw 99 32 population population NN cord-011302-pfepyvaw 99 33 of of IN cord-011302-pfepyvaw 99 34 older old JJR cord-011302-pfepyvaw 99 35 patients patient NNS cord-011302-pfepyvaw 99 36 are be VBP cord-011302-pfepyvaw 99 37 needed need VBN cord-011302-pfepyvaw 99 38 before before IN cord-011302-pfepyvaw 99 39 firm firm JJ cord-011302-pfepyvaw 99 40 conclusions conclusion NNS cord-011302-pfepyvaw 99 41 can can MD cord-011302-pfepyvaw 99 42 be be VB cord-011302-pfepyvaw 99 43 drawn draw VBN cord-011302-pfepyvaw 99 44 . . . cord-011302-pfepyvaw 100 1 This this DT cord-011302-pfepyvaw 100 2 is be VBZ cord-011302-pfepyvaw 100 3 particularly particularly RB cord-011302-pfepyvaw 100 4 important important JJ cord-011302-pfepyvaw 100 5 as as IN cord-011302-pfepyvaw 100 6 29 29 CD cord-011302-pfepyvaw 100 7 - - SYM cord-011302-pfepyvaw 100 8 34 34 CD cord-011302-pfepyvaw 100 9 % % NN cord-011302-pfepyvaw 100 10 of of IN cord-011302-pfepyvaw 100 11 patients patient NNS cord-011302-pfepyvaw 100 12 diagnosed diagnose VBN cord-011302-pfepyvaw 100 13 with with IN cord-011302-pfepyvaw 100 14 an an DT cord-011302-pfepyvaw 100 15 ICH ICH NNP cord-011302-pfepyvaw 100 16 are be VBP cord-011302-pfepyvaw 100 17 ≥ ≥ CD cord-011302-pfepyvaw 100 18 80 80 CD cord-011302-pfepyvaw 100 19 years year NNS cord-011302-pfepyvaw 100 20 old old JJ cord-011302-pfepyvaw 100 21 , , , cord-011302-pfepyvaw 100 22 and and CC cord-011302-pfepyvaw 100 23 this this DT cord-011302-pfepyvaw 100 24 patient patient NN cord-011302-pfepyvaw 100 25 group group NN cord-011302-pfepyvaw 100 26 has have VBZ cord-011302-pfepyvaw 100 27 significantly significantly RB cord-011302-pfepyvaw 100 28 higher high JJR cord-011302-pfepyvaw 100 29 rates rate NNS cord-011302-pfepyvaw 100 30 of of IN cord-011302-pfepyvaw 100 31 in in IN cord-011302-pfepyvaw 100 32 - - HYPH cord-011302-pfepyvaw 100 33 hospital hospital NN cord-011302-pfepyvaw 100 34 mortality mortality NN cord-011302-pfepyvaw 100 35 and and CC cord-011302-pfepyvaw 100 36 unfavourable unfavourable JJ cord-011302-pfepyvaw 100 37 outcome outcome NN cord-011302-pfepyvaw 100 38 [ [ -LRB- cord-011302-pfepyvaw 100 39 3 3 CD cord-011302-pfepyvaw 100 40 , , , cord-011302-pfepyvaw 100 41 35 35 CD cord-011302-pfepyvaw 100 42 ] ] -RRB- cord-011302-pfepyvaw 100 43 . . . cord-011302-pfepyvaw 101 1 Scaggiante Scaggiante NNP cord-011302-pfepyvaw 101 2 also also RB cord-011302-pfepyvaw 101 3 published publish VBD cord-011302-pfepyvaw 101 4 a a DT cord-011302-pfepyvaw 101 5 meta meta NN cord-011302-pfepyvaw 101 6 - - HYPH cord-011302-pfepyvaw 101 7 analysis analysis NN cord-011302-pfepyvaw 101 8 of of IN cord-011302-pfepyvaw 101 9 MIS MIS NNP cord-011302-pfepyvaw 101 10 in in IN cord-011302-pfepyvaw 101 11 2018 2018 CD cord-011302-pfepyvaw 101 12 , , , cord-011302-pfepyvaw 101 13 assessing assess VBG cord-011302-pfepyvaw 101 14 15 15 CD cord-011302-pfepyvaw 101 15 RCTs rct NNS cord-011302-pfepyvaw 101 16 that that WDT cord-011302-pfepyvaw 101 17 mainly mainly RB cord-011302-pfepyvaw 101 18 deployed deploy VBD cord-011302-pfepyvaw 101 19 endoscopic endoscopic NNS cord-011302-pfepyvaw 101 20 and/or and/or CC cord-011302-pfepyvaw 101 21 stereotactic stereotactic JJ cord-011302-pfepyvaw 101 22 thrombolytic thrombolytic NN cord-011302-pfepyvaw 101 23 techniques technique NNS cord-011302-pfepyvaw 101 24 [ [ -LRB- cord-011302-pfepyvaw 101 25 32 32 CD cord-011302-pfepyvaw 101 26 ] ] -RRB- cord-011302-pfepyvaw 101 27 . . . cord-011302-pfepyvaw 102 1 This this DT cord-011302-pfepyvaw 102 2 consolidated consolidate VBD cord-011302-pfepyvaw 102 3 the the DT cord-011302-pfepyvaw 102 4 finding finding NN cord-011302-pfepyvaw 102 5 that that IN cord-011302-pfepyvaw 102 6 MIS MIS NNP cord-011302-pfepyvaw 102 7 improved improve VBN cord-011302-pfepyvaw 102 8 outcome outcome NN cord-011302-pfepyvaw 102 9 compared compare VBN cord-011302-pfepyvaw 102 10 to to IN cord-011302-pfepyvaw 102 11 both both CC cord-011302-pfepyvaw 102 12 craniotomy craniotomy NN cord-011302-pfepyvaw 102 13 and and CC cord-011302-pfepyvaw 102 14 conservative conservative JJ cord-011302-pfepyvaw 102 15 treatment treatment NN cord-011302-pfepyvaw 102 16 . . . cord-011302-pfepyvaw 103 1 Different different JJ cord-011302-pfepyvaw 103 2 MIS MIS NNP cord-011302-pfepyvaw 103 3 techniques technique NNS cord-011302-pfepyvaw 103 4 ( ( -LRB- cord-011302-pfepyvaw 103 5 endoscopy endoscopy NN cord-011302-pfepyvaw 103 6 and and CC cord-011302-pfepyvaw 103 7 stereotactic stereotactic JJ cord-011302-pfepyvaw 103 8 thrombolysis thrombolysis NN cord-011302-pfepyvaw 103 9 ) ) -RRB- cord-011302-pfepyvaw 103 10 both both DT cord-011302-pfepyvaw 103 11 showed show VBD cord-011302-pfepyvaw 103 12 significant significant JJ cord-011302-pfepyvaw 103 13 improvements improvement NNS cord-011302-pfepyvaw 103 14 , , , cord-011302-pfepyvaw 103 15 but but CC cord-011302-pfepyvaw 103 16 these these DT cord-011302-pfepyvaw 103 17 techniques technique NNS cord-011302-pfepyvaw 103 18 have have VBP cord-011302-pfepyvaw 103 19 not not RB cord-011302-pfepyvaw 103 20 been be VBN cord-011302-pfepyvaw 103 21 compared compare VBN cord-011302-pfepyvaw 103 22 directly directly RB cord-011302-pfepyvaw 103 23 . . . cord-011302-pfepyvaw 104 1 Earlier early JJR cord-011302-pfepyvaw 104 2 MIS MIS NNP cord-011302-pfepyvaw 104 3 evacuation evacuation NN cord-011302-pfepyvaw 104 4 of of IN cord-011302-pfepyvaw 104 5 an an DT cord-011302-pfepyvaw 104 6 ICH ICH NNP cord-011302-pfepyvaw 104 7 appeared appear VBD cord-011302-pfepyvaw 104 8 to to TO cord-011302-pfepyvaw 104 9 be be VB cord-011302-pfepyvaw 104 10 associated associate VBN cord-011302-pfepyvaw 104 11 with with IN cord-011302-pfepyvaw 104 12 a a DT cord-011302-pfepyvaw 104 13 better well JJR cord-011302-pfepyvaw 104 14 chance chance NN cord-011302-pfepyvaw 104 15 of of IN cord-011302-pfepyvaw 104 16 achieving achieve VBG cord-011302-pfepyvaw 104 17 functional functional JJ cord-011302-pfepyvaw 104 18 independence independence NN cord-011302-pfepyvaw 104 19 . . . cord-011302-pfepyvaw 105 1 Conversely conversely RB cord-011302-pfepyvaw 105 2 , , , cord-011302-pfepyvaw 105 3 the the DT cord-011302-pfepyvaw 105 4 final final JJ cord-011302-pfepyvaw 105 5 results result NNS cord-011302-pfepyvaw 105 6 of of IN cord-011302-pfepyvaw 105 7 the the DT cord-011302-pfepyvaw 105 8 MISTIE MISTIE NNP cord-011302-pfepyvaw 105 9 3 3 CD cord-011302-pfepyvaw 106 1 ( ( -LRB- cord-011302-pfepyvaw 106 2 Minimially Minimially NNP cord-011302-pfepyvaw 106 3 Invasive invasive JJ cord-011302-pfepyvaw 106 4 Surgery surgery NN cord-011302-pfepyvaw 106 5 with with IN cord-011302-pfepyvaw 106 6 Thrombolysis Thrombolysis NNP cord-011302-pfepyvaw 106 7 in in IN cord-011302-pfepyvaw 106 8 ICH ICH NNP cord-011302-pfepyvaw 106 9 Evacuation Evacuation NNP cord-011302-pfepyvaw 106 10 ) ) -RRB- cord-011302-pfepyvaw 106 11 trial trial NN cord-011302-pfepyvaw 106 12 showed show VBD cord-011302-pfepyvaw 106 13 that that IN cord-011302-pfepyvaw 106 14 aspiration aspiration NN cord-011302-pfepyvaw 106 15 and and CC cord-011302-pfepyvaw 106 16 thrombolytic thrombolytic NN cord-011302-pfepyvaw 106 17 irrigation irrigation NN cord-011302-pfepyvaw 106 18 of of IN cord-011302-pfepyvaw 106 19 an an DT cord-011302-pfepyvaw 106 20 ICH ICH NNP cord-011302-pfepyvaw 106 21 with with IN cord-011302-pfepyvaw 106 22 alteplase alteplase NNP cord-011302-pfepyvaw 106 23 via via IN cord-011302-pfepyvaw 106 24 an an DT cord-011302-pfepyvaw 106 25 image image NN cord-011302-pfepyvaw 106 26 directed direct VBN cord-011302-pfepyvaw 106 27 catheter catheter NN cord-011302-pfepyvaw 106 28 did do VBD cord-011302-pfepyvaw 106 29 not not RB cord-011302-pfepyvaw 106 30 improve improve VB cord-011302-pfepyvaw 106 31 functional functional JJ cord-011302-pfepyvaw 106 32 outcomes outcome NNS cord-011302-pfepyvaw 106 33 compared compare VBN cord-011302-pfepyvaw 106 34 with with IN cord-011302-pfepyvaw 106 35 standard standard JJ cord-011302-pfepyvaw 106 36 care care NN cord-011302-pfepyvaw 106 37 for for IN cord-011302-pfepyvaw 106 38 large large JJ cord-011302-pfepyvaw 106 39 ICHs ich NNS cord-011302-pfepyvaw 106 40 [ [ -LRB- cord-011302-pfepyvaw 106 41 14 14 CD cord-011302-pfepyvaw 106 42 ] ] -RRB- cord-011302-pfepyvaw 106 43 . . . cord-011302-pfepyvaw 107 1 A a DT cord-011302-pfepyvaw 107 2 modest modest JJ cord-011302-pfepyvaw 107 3 survival survival NN cord-011302-pfepyvaw 107 4 benefit benefit NN cord-011302-pfepyvaw 107 5 was be VBD cord-011302-pfepyvaw 107 6 identified identify VBN cord-011302-pfepyvaw 107 7 . . . cord-011302-pfepyvaw 108 1 This this DT cord-011302-pfepyvaw 108 2 trial trial NN cord-011302-pfepyvaw 108 3 only only RB cord-011302-pfepyvaw 108 4 included include VBD cord-011302-pfepyvaw 108 5 patients patient NNS cord-011302-pfepyvaw 108 6 aged aged JJ cord-011302-pfepyvaw 108 7 52 52 CD cord-011302-pfepyvaw 108 8 - - SYM cord-011302-pfepyvaw 108 9 71 71 CD cord-011302-pfepyvaw 108 10 years year NNS cord-011302-pfepyvaw 108 11 old old JJ cord-011302-pfepyvaw 108 12 , , , cord-011302-pfepyvaw 108 13 so so CC cord-011302-pfepyvaw 108 14 caution caution NN cord-011302-pfepyvaw 108 15 must must MD cord-011302-pfepyvaw 108 16 be be VB cord-011302-pfepyvaw 108 17 exercised exercise VBN cord-011302-pfepyvaw 108 18 in in IN cord-011302-pfepyvaw 108 19 applying apply VBG cord-011302-pfepyvaw 108 20 the the DT cord-011302-pfepyvaw 108 21 conclusions conclusion NNS cord-011302-pfepyvaw 108 22 to to IN cord-011302-pfepyvaw 108 23 older old JJR cord-011302-pfepyvaw 108 24 patients patient NNS cord-011302-pfepyvaw 108 25 . . . cord-011302-pfepyvaw 109 1 The the DT cord-011302-pfepyvaw 109 2 comprehensive comprehensive JJ cord-011302-pfepyvaw 109 3 geriatric geriatric JJ cord-011302-pfepyvaw 109 4 assessment assessment NN cord-011302-pfepyvaw 109 5 ( ( -LRB- cord-011302-pfepyvaw 109 6 CGA CGA NNP cord-011302-pfepyvaw 109 7 ) ) -RRB- cord-011302-pfepyvaw 109 8 is be VBZ cord-011302-pfepyvaw 109 9 an an DT cord-011302-pfepyvaw 109 10 established establish VBN cord-011302-pfepyvaw 109 11 tool tool NN cord-011302-pfepyvaw 109 12 used use VBN cord-011302-pfepyvaw 109 13 to to TO cord-011302-pfepyvaw 109 14 assess assess VB cord-011302-pfepyvaw 109 15 the the DT cord-011302-pfepyvaw 109 16 needs need NNS cord-011302-pfepyvaw 109 17 of of IN cord-011302-pfepyvaw 109 18 older old JJR cord-011302-pfepyvaw 109 19 people people NNS cord-011302-pfepyvaw 109 20 and and CC cord-011302-pfepyvaw 109 21 implement implement VB cord-011302-pfepyvaw 109 22 investigations investigation NNS cord-011302-pfepyvaw 109 23 and and CC cord-011302-pfepyvaw 109 24 treatments treatment NNS cord-011302-pfepyvaw 109 25 to to TO cord-011302-pfepyvaw 109 26 improve improve VB cord-011302-pfepyvaw 109 27 long long JJ cord-011302-pfepyvaw 109 28 - - HYPH cord-011302-pfepyvaw 109 29 term term NN cord-011302-pfepyvaw 109 30 outcomes outcome NNS cord-011302-pfepyvaw 109 31 . . . cord-011302-pfepyvaw 110 1 The the DT cord-011302-pfepyvaw 110 2 use use NN cord-011302-pfepyvaw 110 3 of of IN cord-011302-pfepyvaw 110 4 this this DT cord-011302-pfepyvaw 110 5 tool tool NN cord-011302-pfepyvaw 110 6 has have VBZ cord-011302-pfepyvaw 110 7 been be VBN cord-011302-pfepyvaw 110 8 shown show VBN cord-011302-pfepyvaw 110 9 to to TO cord-011302-pfepyvaw 110 10 improve improve VB cord-011302-pfepyvaw 110 11 post post JJ cord-011302-pfepyvaw 110 12 - - JJ cord-011302-pfepyvaw 110 13 operative operative JJ cord-011302-pfepyvaw 110 14 outcomes outcome NNS cord-011302-pfepyvaw 110 15 in in IN cord-011302-pfepyvaw 110 16 older old JJR cord-011302-pfepyvaw 110 17 patients patient NNS cord-011302-pfepyvaw 110 18 undergoing undergo VBG cord-011302-pfepyvaw 110 19 elective elective JJ cord-011302-pfepyvaw 110 20 surgery surgery NN cord-011302-pfepyvaw 110 21 across across IN cord-011302-pfepyvaw 110 22 specialties specialty NNS cord-011302-pfepyvaw 110 23 [ [ -LRB- cord-011302-pfepyvaw 110 24 28 28 CD cord-011302-pfepyvaw 110 25 ] ] -RRB- cord-011302-pfepyvaw 110 26 . . . cord-011302-pfepyvaw 111 1 It -PRON- PRP cord-011302-pfepyvaw 111 2 is be VBZ cord-011302-pfepyvaw 111 3 , , , cord-011302-pfepyvaw 111 4 therefore therefore RB cord-011302-pfepyvaw 111 5 , , , cord-011302-pfepyvaw 111 6 clear clear JJ cord-011302-pfepyvaw 111 7 that that IN cord-011302-pfepyvaw 111 8 older old JJR cord-011302-pfepyvaw 111 9 people people NNS cord-011302-pfepyvaw 111 10 have have VBP cord-011302-pfepyvaw 111 11 different different JJ cord-011302-pfepyvaw 111 12 needs need NNS cord-011302-pfepyvaw 111 13 , , , cord-011302-pfepyvaw 111 14 which which WDT cord-011302-pfepyvaw 111 15 when when WRB cord-011302-pfepyvaw 111 16 identified identify VBN cord-011302-pfepyvaw 111 17 and and CC cord-011302-pfepyvaw 111 18 addressed address VBN cord-011302-pfepyvaw 111 19 can can MD cord-011302-pfepyvaw 111 20 improve improve VB cord-011302-pfepyvaw 111 21 outcomes outcome NNS cord-011302-pfepyvaw 111 22 . . . cord-011302-pfepyvaw 112 1 The the DT cord-011302-pfepyvaw 112 2 CGA CGA NNP cord-011302-pfepyvaw 112 3 is be VBZ cord-011302-pfepyvaw 112 4 a a DT cord-011302-pfepyvaw 112 5 robust robust JJ cord-011302-pfepyvaw 112 6 but but CC cord-011302-pfepyvaw 112 7 cumbersome cumbersome JJ cord-011302-pfepyvaw 112 8 assessment assessment NN cord-011302-pfepyvaw 112 9 including include VBG cord-011302-pfepyvaw 112 10 6 6 CD cord-011302-pfepyvaw 112 11 different different JJ cord-011302-pfepyvaw 112 12 domains domain NNS cord-011302-pfepyvaw 112 13 ( ( -LRB- cord-011302-pfepyvaw 112 14 medical medical JJ cord-011302-pfepyvaw 112 15 , , , cord-011302-pfepyvaw 112 16 mental mental JJ cord-011302-pfepyvaw 112 17 health health NN cord-011302-pfepyvaw 112 18 , , , cord-011302-pfepyvaw 112 19 functional functional JJ cord-011302-pfepyvaw 112 20 capacity capacity NN cord-011302-pfepyvaw 112 21 , , , cord-011302-pfepyvaw 112 22 social social JJ cord-011302-pfepyvaw 112 23 circumstances circumstance NNS cord-011302-pfepyvaw 112 24 , , , cord-011302-pfepyvaw 112 25 environment environment NN cord-011302-pfepyvaw 112 26 , , , cord-011302-pfepyvaw 112 27 and and CC cord-011302-pfepyvaw 112 28 risk risk NN cord-011302-pfepyvaw 112 29 score score NN cord-011302-pfepyvaw 112 30 ) ) -RRB- cord-011302-pfepyvaw 112 31 . . . cord-011302-pfepyvaw 113 1 Identification identification NN cord-011302-pfepyvaw 113 2 of of IN cord-011302-pfepyvaw 113 3 simpler simple JJR cord-011302-pfepyvaw 113 4 tools tool NNS cord-011302-pfepyvaw 113 5 , , , cord-011302-pfepyvaw 113 6 possibly possibly RB cord-011302-pfepyvaw 113 7 even even RB cord-011302-pfepyvaw 113 8 specific specific JJ cord-011302-pfepyvaw 113 9 to to IN cord-011302-pfepyvaw 113 10 neurosurgery neurosurgery NNP cord-011302-pfepyvaw 113 11 , , , cord-011302-pfepyvaw 113 12 are be VBP cord-011302-pfepyvaw 113 13 necessary necessary JJ cord-011302-pfepyvaw 113 14 . . . cord-011302-pfepyvaw 114 1 Understanding understand VBG cord-011302-pfepyvaw 114 2 what what WP cord-011302-pfepyvaw 114 3 is be VBZ cord-011302-pfepyvaw 114 4 meant mean VBN cord-011302-pfepyvaw 114 5 by by IN cord-011302-pfepyvaw 114 6 frailty frailty NN cord-011302-pfepyvaw 114 7 is be VBZ cord-011302-pfepyvaw 114 8 also also RB cord-011302-pfepyvaw 114 9 important important JJ cord-011302-pfepyvaw 114 10 , , , cord-011302-pfepyvaw 114 11 as as IN cord-011302-pfepyvaw 114 12 , , , cord-011302-pfepyvaw 115 1 although although IN cord-011302-pfepyvaw 115 2 there there EX cord-011302-pfepyvaw 115 3 is be VBZ cord-011302-pfepyvaw 115 4 some some DT cord-011302-pfepyvaw 115 5 cross cross NN cord-011302-pfepyvaw 115 6 - - HYPH cord-011302-pfepyvaw 115 7 over over RP cord-011302-pfepyvaw 115 8 with with IN cord-011302-pfepyvaw 115 9 disability disability NN cord-011302-pfepyvaw 115 10 and and CC cord-011302-pfepyvaw 115 11 co co NN cord-011302-pfepyvaw 115 12 - - NN cord-011302-pfepyvaw 115 13 morbidity morbidity NN cord-011302-pfepyvaw 115 14 , , , cord-011302-pfepyvaw 115 15 it -PRON- PRP cord-011302-pfepyvaw 115 16 actually actually RB cord-011302-pfepyvaw 115 17 refers refer VBZ cord-011302-pfepyvaw 115 18 to to IN cord-011302-pfepyvaw 115 19 a a DT cord-011302-pfepyvaw 115 20 physiological physiological JJ cord-011302-pfepyvaw 115 21 state state NN cord-011302-pfepyvaw 115 22 of of IN cord-011302-pfepyvaw 115 23 increased increase VBN cord-011302-pfepyvaw 115 24 vulnerability vulnerability NN cord-011302-pfepyvaw 115 25 to to IN cord-011302-pfepyvaw 115 26 stressors stressor NNS cord-011302-pfepyvaw 115 27 due due JJ cord-011302-pfepyvaw 115 28 to to IN cord-011302-pfepyvaw 115 29 decreased decrease VBD cord-011302-pfepyvaw 115 30 physiological physiological JJ cord-011302-pfepyvaw 115 31 reserve reserve NN cord-011302-pfepyvaw 115 32 [ [ -LRB- cord-011302-pfepyvaw 115 33 12 12 CD cord-011302-pfepyvaw 115 34 ] ] -RRB- cord-011302-pfepyvaw 115 35 . . . cord-011302-pfepyvaw 116 1 A a DT cord-011302-pfepyvaw 116 2 frailty frailty NN cord-011302-pfepyvaw 116 3 score score NN cord-011302-pfepyvaw 116 4 based base VBN cord-011302-pfepyvaw 116 5 on on IN cord-011302-pfepyvaw 116 6 the the DT cord-011302-pfepyvaw 116 7 assessment assessment NN cord-011302-pfepyvaw 116 8 of of IN cord-011302-pfepyvaw 116 9 data datum NNS cord-011302-pfepyvaw 116 10 from from IN cord-011302-pfepyvaw 116 11 27,098 27,098 CD cord-011302-pfepyvaw 116 12 cranial cranial JJ cord-011302-pfepyvaw 116 13 neurosurgical neurosurgical JJ cord-011302-pfepyvaw 116 14 cases case NNS cord-011302-pfepyvaw 116 15 has have VBZ cord-011302-pfepyvaw 116 16 been be VBN cord-011302-pfepyvaw 116 17 reported report VBN cord-011302-pfepyvaw 116 18 , , , cord-011302-pfepyvaw 116 19 where where WRB cord-011302-pfepyvaw 116 20 higher high JJR cord-011302-pfepyvaw 116 21 scores score NNS cord-011302-pfepyvaw 116 22 had have VBD cord-011302-pfepyvaw 116 23 good good JJ cord-011302-pfepyvaw 116 24 sensitivity sensitivity NN cord-011302-pfepyvaw 116 25 and and CC cord-011302-pfepyvaw 116 26 specificity specificity NN cord-011302-pfepyvaw 116 27 for for IN cord-011302-pfepyvaw 116 28 predicting predict VBG cord-011302-pfepyvaw 116 29 increased increase VBN cord-011302-pfepyvaw 116 30 30-day 30-day CD cord-011302-pfepyvaw 116 31 mortality mortality NN cord-011302-pfepyvaw 116 32 [ [ -LRB- cord-011302-pfepyvaw 116 33 39 39 CD cord-011302-pfepyvaw 116 34 ] ] -RRB- cord-011302-pfepyvaw 116 35 . . . cord-011302-pfepyvaw 117 1 The the DT cord-011302-pfepyvaw 117 2 score score NN cord-011302-pfepyvaw 117 3 considered consider VBN cord-011302-pfepyvaw 117 4 19 19 CD cord-011302-pfepyvaw 117 5 predictors predictor NNS cord-011302-pfepyvaw 117 6 of of IN cord-011302-pfepyvaw 117 7 mortality mortality NN cord-011302-pfepyvaw 117 8 , , , cord-011302-pfepyvaw 117 9 with with IN cord-011302-pfepyvaw 117 10 the the DT cord-011302-pfepyvaw 117 11 most most RBS cord-011302-pfepyvaw 117 12 significant significant JJ cord-011302-pfepyvaw 117 13 including include VBG cord-011302-pfepyvaw 117 14 ascites ascites NN cord-011302-pfepyvaw 117 15 , , , cord-011302-pfepyvaw 117 16 ventilator ventilator NN cord-011302-pfepyvaw 117 17 dependency dependency NN cord-011302-pfepyvaw 117 18 and and CC cord-011302-pfepyvaw 117 19 renal renal JJ cord-011302-pfepyvaw 117 20 failure failure NN cord-011302-pfepyvaw 117 21 , , , cord-011302-pfepyvaw 117 22 alongside alongside IN cord-011302-pfepyvaw 117 23 more more JJR cord-011302-pfepyvaw 117 24 common common JJ cord-011302-pfepyvaw 117 25 problems problem NNS cord-011302-pfepyvaw 117 26 such such JJ cord-011302-pfepyvaw 117 27 as as IN cord-011302-pfepyvaw 117 28 anti anti JJ cord-011302-pfepyvaw 117 29 - - JJ cord-011302-pfepyvaw 117 30 hypertensive hypertensive JJ cord-011302-pfepyvaw 117 31 medication medication NN cord-011302-pfepyvaw 117 32 use use NN cord-011302-pfepyvaw 117 33 , , , cord-011302-pfepyvaw 117 34 high high JJ cord-011302-pfepyvaw 117 35 white white JJ cord-011302-pfepyvaw 117 36 cell cell NN cord-011302-pfepyvaw 117 37 count count NN cord-011302-pfepyvaw 117 38 and and CC cord-011302-pfepyvaw 117 39 low low JJ cord-011302-pfepyvaw 117 40 body body NN cord-011302-pfepyvaw 117 41 mass mass NN cord-011302-pfepyvaw 117 42 index index NN cord-011302-pfepyvaw 117 43 . . . cord-011302-pfepyvaw 118 1 The the DT cord-011302-pfepyvaw 118 2 disadvantages disadvantage NNS cord-011302-pfepyvaw 118 3 are be VBP cord-011302-pfepyvaw 118 4 that that IN cord-011302-pfepyvaw 118 5 this this DT cord-011302-pfepyvaw 118 6 score score NN cord-011302-pfepyvaw 118 7 still still RB cord-011302-pfepyvaw 118 8 contains contain VBZ cord-011302-pfepyvaw 118 9 a a DT cord-011302-pfepyvaw 118 10 large large JJ cord-011302-pfepyvaw 118 11 number number NN cord-011302-pfepyvaw 118 12 of of IN cord-011302-pfepyvaw 118 13 variables variable NNS cord-011302-pfepyvaw 118 14 and and CC cord-011302-pfepyvaw 118 15 requires require VBZ cord-011302-pfepyvaw 118 16 prospective prospective JJ cord-011302-pfepyvaw 118 17 evaluation evaluation NN cord-011302-pfepyvaw 118 18 . . . cord-011302-pfepyvaw 119 1 Tools tool NNS cord-011302-pfepyvaw 119 2 such such JJ cord-011302-pfepyvaw 119 3 as as IN cord-011302-pfepyvaw 119 4 the the DT cord-011302-pfepyvaw 119 5 modified modify VBN cord-011302-pfepyvaw 119 6 Frailty Frailty NNP cord-011302-pfepyvaw 119 7 Index Index NNP cord-011302-pfepyvaw 119 8 ( ( -LRB- cord-011302-pfepyvaw 119 9 mFI mFI NNP cord-011302-pfepyvaw 119 10 ) ) -RRB- cord-011302-pfepyvaw 119 11 , , , cord-011302-pfepyvaw 119 12 that that WDT cord-011302-pfepyvaw 119 13 have have VBP cord-011302-pfepyvaw 119 14 already already RB cord-011302-pfepyvaw 119 15 been be VBN cord-011302-pfepyvaw 119 16 well well RB cord-011302-pfepyvaw 119 17 validated validate VBN cord-011302-pfepyvaw 119 18 in in IN cord-011302-pfepyvaw 119 19 surgical surgical JJ cord-011302-pfepyvaw 119 20 populations population NNS cord-011302-pfepyvaw 119 21 , , , cord-011302-pfepyvaw 119 22 may may MD cord-011302-pfepyvaw 119 23 be be VB cord-011302-pfepyvaw 119 24 more more RBR cord-011302-pfepyvaw 119 25 useful useful JJ cord-011302-pfepyvaw 119 26 [ [ -LRB- cord-011302-pfepyvaw 119 27 11 11 CD cord-011302-pfepyvaw 119 28 , , , cord-011302-pfepyvaw 119 29 40 40 CD cord-011302-pfepyvaw 119 30 ] ] -RRB- cord-011302-pfepyvaw 119 31 . . . cord-011302-pfepyvaw 120 1 Youngerman Youngerman NNP cord-011302-pfepyvaw 120 2 reviewed review VBD cord-011302-pfepyvaw 120 3 9149 9149 CD cord-011302-pfepyvaw 120 4 patients patient NNS cord-011302-pfepyvaw 120 5 with with IN cord-011302-pfepyvaw 120 6 brain brain NN cord-011302-pfepyvaw 120 7 tumours tumour NNS cord-011302-pfepyvaw 120 8 and and CC cord-011302-pfepyvaw 120 9 found find VBD cord-011302-pfepyvaw 120 10 increased increase VBN cord-011302-pfepyvaw 120 11 higher high JJR cord-011302-pfepyvaw 120 12 mFI mFI NNS cord-011302-pfepyvaw 120 13 scores score NNS cord-011302-pfepyvaw 120 14 were be VBD cord-011302-pfepyvaw 120 15 associated associate VBN cord-011302-pfepyvaw 120 16 with with IN cord-011302-pfepyvaw 120 17 increased increase VBN cord-011302-pfepyvaw 120 18 mortality mortality NN cord-011302-pfepyvaw 120 19 , , , cord-011302-pfepyvaw 120 20 severe severe JJ cord-011302-pfepyvaw 120 21 neurological neurological JJ cord-011302-pfepyvaw 120 22 complications complication NNS cord-011302-pfepyvaw 120 23 and and CC cord-011302-pfepyvaw 120 24 prolonged prolong VBN cord-011302-pfepyvaw 120 25 length length NN cord-011302-pfepyvaw 120 26 of of IN cord-011302-pfepyvaw 120 27 stay stay NN cord-011302-pfepyvaw 120 28 [ [ -LRB- cord-011302-pfepyvaw 120 29 46 46 CD cord-011302-pfepyvaw 120 30 ] ] -RRB- cord-011302-pfepyvaw 120 31 . . . cord-011302-pfepyvaw 121 1 Combined combined JJ cord-011302-pfepyvaw 121 2 assessment assessment NN cord-011302-pfepyvaw 121 3 of of IN cord-011302-pfepyvaw 121 4 mFI mfi NN cord-011302-pfepyvaw 121 5 , , , cord-011302-pfepyvaw 121 6 age age NN cord-011302-pfepyvaw 121 7 and and CC cord-011302-pfepyvaw 121 8 ASA ASA NNP cord-011302-pfepyvaw 121 9 ( ( -LRB- cord-011302-pfepyvaw 121 10 American American NNP cord-011302-pfepyvaw 121 11 Society Society NNP cord-011302-pfepyvaw 121 12 of of IN cord-011302-pfepyvaw 121 13 Anaesthesiologists Anaesthesiologists NNP cord-011302-pfepyvaw 121 14 ) ) -RRB- cord-011302-pfepyvaw 121 15 classification classification NN cord-011302-pfepyvaw 121 16 gave give VBD cord-011302-pfepyvaw 121 17 the the DT cord-011302-pfepyvaw 121 18 best good JJS cord-011302-pfepyvaw 121 19 predictive predictive JJ cord-011302-pfepyvaw 121 20 ability ability NN cord-011302-pfepyvaw 121 21 on on IN cord-011302-pfepyvaw 121 22 overall overall JJ cord-011302-pfepyvaw 121 23 outcome outcome NN cord-011302-pfepyvaw 121 24 . . . cord-011302-pfepyvaw 122 1 A a DT cord-011302-pfepyvaw 122 2 simpler simple JJR cord-011302-pfepyvaw 122 3 scale scale NN cord-011302-pfepyvaw 122 4 , , , cord-011302-pfepyvaw 122 5 the the DT cord-011302-pfepyvaw 122 6 clinical clinical JJ cord-011302-pfepyvaw 122 7 frailty frailty NN cord-011302-pfepyvaw 122 8 scale scale NN cord-011302-pfepyvaw 122 9 , , , cord-011302-pfepyvaw 122 10 has have VBZ cord-011302-pfepyvaw 122 11 also also RB cord-011302-pfepyvaw 122 12 been be VBN cord-011302-pfepyvaw 122 13 applied apply VBN cord-011302-pfepyvaw 122 14 in in IN cord-011302-pfepyvaw 122 15 neurosurgical neurosurgical JJ cord-011302-pfepyvaw 122 16 patients patient NNS cord-011302-pfepyvaw 122 17 , , , cord-011302-pfepyvaw 122 18 predicting predict VBG cord-011302-pfepyvaw 122 19 prognosis prognosis NN cord-011302-pfepyvaw 122 20 in in IN cord-011302-pfepyvaw 122 21 operated operate VBN cord-011302-pfepyvaw 122 22 CSDH CSDH NNP cord-011302-pfepyvaw 122 23 [ [ -LRB- cord-011302-pfepyvaw 122 24 29 29 CD cord-011302-pfepyvaw 122 25 , , , cord-011302-pfepyvaw 122 26 34 34 CD cord-011302-pfepyvaw 122 27 ] ] -RRB- cord-011302-pfepyvaw 122 28 . . . cord-011302-pfepyvaw 123 1 Frailty frailty NN cord-011302-pfepyvaw 123 2 has have VBZ cord-011302-pfepyvaw 123 3 also also RB cord-011302-pfepyvaw 123 4 been be VBN cord-011302-pfepyvaw 123 5 correlated correlate VBN cord-011302-pfepyvaw 123 6 with with IN cord-011302-pfepyvaw 123 7 poor poor JJ cord-011302-pfepyvaw 123 8 outcome outcome NN cord-011302-pfepyvaw 123 9 in in IN cord-011302-pfepyvaw 123 10 older old JJR cord-011302-pfepyvaw 123 11 patients patient NNS cord-011302-pfepyvaw 123 12 with with IN cord-011302-pfepyvaw 123 13 aneurysmal aneurysmal NNP cord-011302-pfepyvaw 123 14 SAH SAH NNP cord-011302-pfepyvaw 123 15 , , , cord-011302-pfepyvaw 123 16 however however RB cord-011302-pfepyvaw 123 17 this this DT cord-011302-pfepyvaw 123 18 was be VBD cord-011302-pfepyvaw 123 19 a a DT cord-011302-pfepyvaw 123 20 very very RB cord-011302-pfepyvaw 123 21 simplistic simplistic JJ cord-011302-pfepyvaw 123 22 assessment assessment NN cord-011302-pfepyvaw 123 23 of of IN cord-011302-pfepyvaw 123 24 frailty frailty NN cord-011302-pfepyvaw 123 25 based base VBN cord-011302-pfepyvaw 123 26 on on IN cord-011302-pfepyvaw 123 27 haemoglobin haemoglobin NN cord-011302-pfepyvaw 123 28 , , , cord-011302-pfepyvaw 123 29 albumin albumin NN cord-011302-pfepyvaw 123 30 and and CC cord-011302-pfepyvaw 123 31 BMI BMI NNP cord-011302-pfepyvaw 123 32 [ [ -LRB- cord-011302-pfepyvaw 123 33 47 47 CD cord-011302-pfepyvaw 123 34 ] ] -RRB- cord-011302-pfepyvaw 123 35 . . . cord-011302-pfepyvaw 124 1 Standardised standardised JJ cord-011302-pfepyvaw 124 2 assessments assessment NNS cord-011302-pfepyvaw 124 3 of of IN cord-011302-pfepyvaw 124 4 frailty frailty NN cord-011302-pfepyvaw 124 5 are be VBP cord-011302-pfepyvaw 124 6 needed need VBN cord-011302-pfepyvaw 124 7 , , , cord-011302-pfepyvaw 124 8 with with IN cord-011302-pfepyvaw 124 9 validation validation NN cord-011302-pfepyvaw 124 10 in in IN cord-011302-pfepyvaw 124 11 large large JJ cord-011302-pfepyvaw 124 12 cohorts cohort NNS cord-011302-pfepyvaw 124 13 of of IN cord-011302-pfepyvaw 124 14 neurosurgical neurosurgical JJ cord-011302-pfepyvaw 124 15 patients patient NNS cord-011302-pfepyvaw 124 16 across across IN cord-011302-pfepyvaw 124 17 a a DT cord-011302-pfepyvaw 124 18 range range NN cord-011302-pfepyvaw 124 19 of of IN cord-011302-pfepyvaw 124 20 pathologies pathology NNS cord-011302-pfepyvaw 124 21 . . . cord-011302-pfepyvaw 125 1 This this DT cord-011302-pfepyvaw 125 2 may may MD cord-011302-pfepyvaw 125 3 then then RB cord-011302-pfepyvaw 125 4 support support VB cord-011302-pfepyvaw 125 5 the the DT cord-011302-pfepyvaw 125 6 development development NN cord-011302-pfepyvaw 125 7 of of IN cord-011302-pfepyvaw 125 8 prognostication prognostication NN cord-011302-pfepyvaw 125 9 tools tool NNS cord-011302-pfepyvaw 125 10 and and CC cord-011302-pfepyvaw 125 11 aid aid VB cord-011302-pfepyvaw 125 12 clinical clinical JJ cord-011302-pfepyvaw 125 13 decisionmaking decisionmaking NN cord-011302-pfepyvaw 125 14 and and CC cord-011302-pfepyvaw 125 15 family family NN cord-011302-pfepyvaw 125 16 discussions discussion NNS cord-011302-pfepyvaw 125 17 . . . cord-011302-pfepyvaw 126 1 At at IN cord-011302-pfepyvaw 126 2 what what WDT cord-011302-pfepyvaw 126 3 point point NN cord-011302-pfepyvaw 126 4 we -PRON- PRP cord-011302-pfepyvaw 126 5 consider consider VBP cord-011302-pfepyvaw 126 6 a a DT cord-011302-pfepyvaw 126 7 person person NN cord-011302-pfepyvaw 126 8 to to TO cord-011302-pfepyvaw 126 9 be be VB cord-011302-pfepyvaw 126 10 " " `` cord-011302-pfepyvaw 126 11 elderly elderly JJ cord-011302-pfepyvaw 126 12 " " '' cord-011302-pfepyvaw 126 13 is be VBZ cord-011302-pfepyvaw 126 14 shifting shift VBG cord-011302-pfepyvaw 126 15 , , , cord-011302-pfepyvaw 126 16 as as IN cord-011302-pfepyvaw 126 17 patients patient NNS cord-011302-pfepyvaw 126 18 are be VBP cord-011302-pfepyvaw 126 19 fitter fit JJR cord-011302-pfepyvaw 126 20 and and CC cord-011302-pfepyvaw 126 21 more more RBR cord-011302-pfepyvaw 126 22 independent independent JJ cord-011302-pfepyvaw 126 23 until until IN cord-011302-pfepyvaw 126 24 later later RB cord-011302-pfepyvaw 126 25 in in IN cord-011302-pfepyvaw 126 26 life life NN cord-011302-pfepyvaw 126 27 . . . cord-011302-pfepyvaw 127 1 There there EX cord-011302-pfepyvaw 127 2 are be VBP cord-011302-pfepyvaw 127 3 also also RB cord-011302-pfepyvaw 127 4 neurosurgical neurosurgical JJ cord-011302-pfepyvaw 127 5 advances advance NNS cord-011302-pfepyvaw 127 6 which which WDT cord-011302-pfepyvaw 127 7 may may MD cord-011302-pfepyvaw 127 8 preferentially preferentially RB cord-011302-pfepyvaw 127 9 benefit benefit VB cord-011302-pfepyvaw 127 10 older old JJR cord-011302-pfepyvaw 127 11 patients patient NNS cord-011302-pfepyvaw 127 12 with with IN cord-011302-pfepyvaw 127 13 multiple multiple JJ cord-011302-pfepyvaw 127 14 co co NNS cord-011302-pfepyvaw 127 15 - - NNS cord-011302-pfepyvaw 127 16 morbidities morbidity NNS cord-011302-pfepyvaw 127 17 such such JJ cord-011302-pfepyvaw 127 18 as as IN cord-011302-pfepyvaw 127 19 endovascular endovascular JJ cord-011302-pfepyvaw 127 20 coiling coiling NN cord-011302-pfepyvaw 127 21 and and CC cord-011302-pfepyvaw 127 22 MIS mis NN cord-011302-pfepyvaw 127 23 surgery surgery NN cord-011302-pfepyvaw 127 24 for for IN cord-011302-pfepyvaw 127 25 ICH ICH NNP cord-011302-pfepyvaw 127 26 . . . cord-011302-pfepyvaw 128 1 Patients patient NNS cord-011302-pfepyvaw 128 2 aged age VBN cord-011302-pfepyvaw 128 3 over over IN cord-011302-pfepyvaw 128 4 65 65 CD cord-011302-pfepyvaw 128 5 years year NNS cord-011302-pfepyvaw 128 6 of of IN cord-011302-pfepyvaw 128 7 age age NN cord-011302-pfepyvaw 128 8 certainly certainly RB cord-011302-pfepyvaw 128 9 do do VBP cord-011302-pfepyvaw 128 10 benefit benefit NN cord-011302-pfepyvaw 128 11 from from IN cord-011302-pfepyvaw 128 12 acute acute JJ cord-011302-pfepyvaw 128 13 neurosurgical neurosurgical JJ cord-011302-pfepyvaw 128 14 interventions intervention NNS cord-011302-pfepyvaw 128 15 , , , cord-011302-pfepyvaw 128 16 but but CC cord-011302-pfepyvaw 128 17 there there EX cord-011302-pfepyvaw 128 18 is be VBZ cord-011302-pfepyvaw 128 19 more more JJR cord-011302-pfepyvaw 128 20 uncertainty uncertainty NN cord-011302-pfepyvaw 128 21 and and CC cord-011302-pfepyvaw 128 22 risk risk NN cord-011302-pfepyvaw 128 23 for for IN cord-011302-pfepyvaw 128 24 those those DT cord-011302-pfepyvaw 128 25 aged age VBN cord-011302-pfepyvaw 128 26 over over IN cord-011302-pfepyvaw 128 27 80 80 CD cord-011302-pfepyvaw 128 28 . . . cord-011302-pfepyvaw 129 1 An an DT cord-011302-pfepyvaw 129 2 age age NN cord-011302-pfepyvaw 129 3 cut cut VBN cord-011302-pfepyvaw 129 4 - - HYPH cord-011302-pfepyvaw 129 5 off off RP cord-011302-pfepyvaw 129 6 itself -PRON- PRP cord-011302-pfepyvaw 129 7 may may MD cord-011302-pfepyvaw 129 8 not not RB cord-011302-pfepyvaw 129 9 be be VB cord-011302-pfepyvaw 129 10 helpful helpful JJ cord-011302-pfepyvaw 129 11 , , , cord-011302-pfepyvaw 129 12 but but CC cord-011302-pfepyvaw 129 13 rather rather RB cord-011302-pfepyvaw 129 14 frailty frailty NN cord-011302-pfepyvaw 129 15 should should MD cord-011302-pfepyvaw 129 16 be be VB cord-011302-pfepyvaw 129 17 considered consider VBN cord-011302-pfepyvaw 129 18 instead instead RB cord-011302-pfepyvaw 129 19 , , , cord-011302-pfepyvaw 129 20 and and CC cord-011302-pfepyvaw 129 21 we -PRON- PRP cord-011302-pfepyvaw 129 22 advocate advocate VBP cord-011302-pfepyvaw 129 23 improved improve VBD cord-011302-pfepyvaw 129 24 reporting reporting NN cord-011302-pfepyvaw 129 25 of of IN cord-011302-pfepyvaw 129 26 this this DT cord-011302-pfepyvaw 129 27 metric metric NN cord-011302-pfepyvaw 129 28 in in IN cord-011302-pfepyvaw 129 29 future future JJ cord-011302-pfepyvaw 129 30 trials trial NNS cord-011302-pfepyvaw 129 31 and and CC cord-011302-pfepyvaw 129 32 studies study NNS cord-011302-pfepyvaw 129 33 . . . cord-011302-pfepyvaw 130 1 Most most RBS cord-011302-pfepyvaw 130 2 importantly importantly RB cord-011302-pfepyvaw 130 3 , , , cord-011302-pfepyvaw 130 4 given give VBN cord-011302-pfepyvaw 130 5 the the DT cord-011302-pfepyvaw 130 6 lack lack NN cord-011302-pfepyvaw 130 7 of of IN cord-011302-pfepyvaw 130 8 robust robust JJ cord-011302-pfepyvaw 130 9 evidence evidence NN cord-011302-pfepyvaw 130 10 , , , cord-011302-pfepyvaw 130 11 determining determine VBG cord-011302-pfepyvaw 130 12 patient patient JJ cord-011302-pfepyvaw 130 13 eligibility eligibility NN cord-011302-pfepyvaw 130 14 for for IN cord-011302-pfepyvaw 130 15 intervention intervention NN cord-011302-pfepyvaw 130 16 is be VBZ cord-011302-pfepyvaw 130 17 often often RB cord-011302-pfepyvaw 130 18 left leave VBN cord-011302-pfepyvaw 130 19 to to IN cord-011302-pfepyvaw 130 20 the the DT cord-011302-pfepyvaw 130 21 treating treat VBG cord-011302-pfepyvaw 130 22 clinician clinician NN cord-011302-pfepyvaw 130 23 . . . cord-011302-pfepyvaw 131 1 Whilst whilst IN cord-011302-pfepyvaw 131 2 it -PRON- PRP cord-011302-pfepyvaw 131 3 is be VBZ cord-011302-pfepyvaw 131 4 always always RB cord-011302-pfepyvaw 131 5 possible possible JJ cord-011302-pfepyvaw 131 6 to to TO cord-011302-pfepyvaw 131 7 intervene intervene VB cord-011302-pfepyvaw 131 8 , , , cord-011302-pfepyvaw 131 9 it -PRON- PRP cord-011302-pfepyvaw 131 10 is be VBZ cord-011302-pfepyvaw 131 11 not not RB cord-011302-pfepyvaw 131 12 always always RB cord-011302-pfepyvaw 131 13 appropriate appropriate JJ cord-011302-pfepyvaw 131 14 and and CC cord-011302-pfepyvaw 131 15 a a DT cord-011302-pfepyvaw 131 16 significantly significantly RB cord-011302-pfepyvaw 131 17 lower low JJR cord-011302-pfepyvaw 131 18 likelihood likelihood NN cord-011302-pfepyvaw 131 19 of of IN cord-011302-pfepyvaw 131 20 maintaining maintain VBG cord-011302-pfepyvaw 131 21 the the DT cord-011302-pfepyvaw 131 22 quality quality NN cord-011302-pfepyvaw 131 23 of of IN cord-011302-pfepyvaw 131 24 life life NN cord-011302-pfepyvaw 131 25 in in IN cord-011302-pfepyvaw 131 26 older old JJR cord-011302-pfepyvaw 131 27 patients patient NNS cord-011302-pfepyvaw 131 28 for for IN cord-011302-pfepyvaw 131 29 the the DT cord-011302-pfepyvaw 131 30 conditions condition NNS cord-011302-pfepyvaw 131 31 discussed discuss VBN cord-011302-pfepyvaw 131 32 must must MD cord-011302-pfepyvaw 131 33 be be VB cord-011302-pfepyvaw 131 34 recognised recognise VBN cord-011302-pfepyvaw 131 35 . . . cord-011302-pfepyvaw 132 1 On on IN cord-011302-pfepyvaw 132 2 the the DT cord-011302-pfepyvaw 132 3 other other JJ cord-011302-pfepyvaw 132 4 hand hand NN cord-011302-pfepyvaw 132 5 , , , cord-011302-pfepyvaw 132 6 a a DT cord-011302-pfepyvaw 132 7 therapeutic therapeutic JJ cord-011302-pfepyvaw 132 8 nihilism nihilism NN cord-011302-pfepyvaw 132 9 may may MD cord-011302-pfepyvaw 132 10 be be VB cord-011302-pfepyvaw 132 11 deterministic deterministic JJ cord-011302-pfepyvaw 132 12 and and CC cord-011302-pfepyvaw 132 13 thwart thwart VB cord-011302-pfepyvaw 132 14 development development NN cord-011302-pfepyvaw 132 15 of of IN cord-011302-pfepyvaw 132 16 improved improved JJ cord-011302-pfepyvaw 132 17 clinical clinical JJ cord-011302-pfepyvaw 132 18 practice practice NN cord-011302-pfepyvaw 132 19 in in IN cord-011302-pfepyvaw 132 20 this this DT cord-011302-pfepyvaw 132 21 group group NN cord-011302-pfepyvaw 132 22 of of IN cord-011302-pfepyvaw 132 23 patients patient NNS cord-011302-pfepyvaw 132 24 . . . cord-011302-pfepyvaw 133 1 Conflicts conflict NNS cord-011302-pfepyvaw 133 2 of of IN cord-011302-pfepyvaw 133 3 interest interest NN cord-011302-pfepyvaw 134 1 On on IN cord-011302-pfepyvaw 134 2 behalf behalf NN cord-011302-pfepyvaw 134 3 of of IN cord-011302-pfepyvaw 134 4 all all DT cord-011302-pfepyvaw 134 5 authors author NNS cord-011302-pfepyvaw 134 6 , , , cord-011302-pfepyvaw 134 7 the the DT cord-011302-pfepyvaw 134 8 corresponding correspond VBG cord-011302-pfepyvaw 134 9 author author NN cord-011302-pfepyvaw 134 10 states state VBZ cord-011302-pfepyvaw 134 11 that that IN cord-011302-pfepyvaw 134 12 there there EX cord-011302-pfepyvaw 134 13 is be VBZ cord-011302-pfepyvaw 134 14 no no DT cord-011302-pfepyvaw 134 15 conflict conflict NN cord-011302-pfepyvaw 134 16 of of IN cord-011302-pfepyvaw 134 17 interest interest NN cord-011302-pfepyvaw 134 18 . . . cord-011302-pfepyvaw 135 1 Development development NN cord-011302-pfepyvaw 135 2 of of IN cord-011302-pfepyvaw 135 3 the the DT cord-011302-pfepyvaw 135 4 Subdural Subdural NNP cord-011302-pfepyvaw 135 5 Hematoma hematoma NN cord-011302-pfepyvaw 135 6 in in IN cord-011302-pfepyvaw 135 7 the the DT cord-011302-pfepyvaw 135 8 Elderly Elderly NNP cord-011302-pfepyvaw 135 9 ( ( -LRB- cord-011302-pfepyvaw 135 10 SHE she NN cord-011302-pfepyvaw 135 11 ) ) -RRB- cord-011302-pfepyvaw 135 12 score score NN cord-011302-pfepyvaw 135 13 to to TO cord-011302-pfepyvaw 135 14 predict predict VB cord-011302-pfepyvaw 135 15 mortality mortality NN cord-011302-pfepyvaw 135 16 Hypothermia hypothermia NN cord-011302-pfepyvaw 135 17 for for IN cord-011302-pfepyvaw 135 18 Intracranial intracranial JJ cord-011302-pfepyvaw 135 19 Hypertension hypertension NN cord-011302-pfepyvaw 135 20 after after IN cord-011302-pfepyvaw 135 21 Traumatic Traumatic NNP cord-011302-pfepyvaw 135 22 Brain Brain NNP cord-011302-pfepyvaw 135 23 Injury Injury NNP cord-011302-pfepyvaw 135 24 Spontaneous spontaneous JJ cord-011302-pfepyvaw 135 25 intracerebral intracerebral JJ cord-011302-pfepyvaw 135 26 hemorrhage hemorrhage NN cord-011302-pfepyvaw 135 27 in in IN cord-011302-pfepyvaw 135 28 the the DT cord-011302-pfepyvaw 135 29 elderly elderly JJ cord-011302-pfepyvaw 135 30 population population NN cord-011302-pfepyvaw 135 31 ( ( -LRB- cord-011302-pfepyvaw 135 32 S10.006 S10.006 NNP cord-011302-pfepyvaw 135 33 ) ) -RRB- cord-011302-pfepyvaw 136 1 The the DT cord-011302-pfepyvaw 136 2 management management NN cord-011302-pfepyvaw 136 3 and and CC cord-011302-pfepyvaw 136 4 outcome outcome NN cord-011302-pfepyvaw 136 5 for for IN cord-011302-pfepyvaw 136 6 patients patient NNS cord-011302-pfepyvaw 136 7 with with IN cord-011302-pfepyvaw 136 8 chronic chronic JJ cord-011302-pfepyvaw 136 9 subdural subdural JJ cord-011302-pfepyvaw 136 10 hematoma hematoma NN cord-011302-pfepyvaw 136 11 : : : cord-011302-pfepyvaw 136 12 a a DT cord-011302-pfepyvaw 136 13 prospective prospective JJ cord-011302-pfepyvaw 136 14 , , , cord-011302-pfepyvaw 136 15 multicenter multicenter JJ cord-011302-pfepyvaw 136 16 , , , cord-011302-pfepyvaw 136 17 observational observational JJ cord-011302-pfepyvaw 136 18 cohort cohort NN cord-011302-pfepyvaw 136 19 study study NN cord-011302-pfepyvaw 136 20 in in IN cord-011302-pfepyvaw 136 21 the the DT cord-011302-pfepyvaw 136 22 United United NNP cord-011302-pfepyvaw 136 23 Kingdom Kingdom NNP cord-011302-pfepyvaw 136 24 Global Global NNP cord-011302-pfepyvaw 136 25 Neurotrauma Neurotrauma NNP cord-011302-pfepyvaw 136 26 Research Research NNP cord-011302-pfepyvaw 136 27 G G NNP cord-011302-pfepyvaw 136 28 ( ( -LRB- cord-011302-pfepyvaw 136 29 2012 2012 CD cord-011302-pfepyvaw 136 30 ) ) -RRB- cord-011302-pfepyvaw 137 1 A a DT cord-011302-pfepyvaw 137 2 trial trial NN cord-011302-pfepyvaw 137 3 of of IN cord-011302-pfepyvaw 137 4 intracranial intracranial JJ cord-011302-pfepyvaw 137 5 - - HYPH cord-011302-pfepyvaw 137 6 pressure pressure NN cord-011302-pfepyvaw 137 7 monitoring monitoring NN cord-011302-pfepyvaw 137 8 in in IN cord-011302-pfepyvaw 137 9 traumatic traumatic JJ cord-011302-pfepyvaw 137 10 brain brain NN cord-011302-pfepyvaw 137 11 injury injury NN cord-011302-pfepyvaw 137 12 Neurosurgery Neurosurgery NNP cord-011302-pfepyvaw 137 13 and and CC cord-011302-pfepyvaw 137 14 elderly elderly JJ cord-011302-pfepyvaw 137 15 : : : cord-011302-pfepyvaw 137 16 analysis analysis NN cord-011302-pfepyvaw 137 17 through through IN cord-011302-pfepyvaw 137 18 the the DT cord-011302-pfepyvaw 137 19 years year NNS cord-011302-pfepyvaw 137 20 Decompressive Decompressive NNP cord-011302-pfepyvaw 137 21 craniectomy craniectomy VBP cord-011302-pfepyvaw 137 22 in in IN cord-011302-pfepyvaw 137 23 diffuse diffuse JJ cord-011302-pfepyvaw 137 24 traumatic traumatic JJ cord-011302-pfepyvaw 137 25 brain brain NN cord-011302-pfepyvaw 137 26 injury injury NN cord-011302-pfepyvaw 137 27 Pathophysiology pathophysiology NN cord-011302-pfepyvaw 137 28 of of IN cord-011302-pfepyvaw 137 29 chronic chronic JJ cord-011302-pfepyvaw 137 30 subdural subdural JJ cord-011302-pfepyvaw 137 31 haematoma haematoma NN cord-011302-pfepyvaw 137 32 : : : cord-011302-pfepyvaw 137 33 inflammation inflammation NN cord-011302-pfepyvaw 137 34 , , , cord-011302-pfepyvaw 137 35 angiogenesis angiogenesis NN cord-011302-pfepyvaw 137 36 and and CC cord-011302-pfepyvaw 137 37 implications implication NNS cord-011302-pfepyvaw 137 38 for for IN cord-011302-pfepyvaw 137 39 pharmacotherapy pharmacotherapy NN cord-011302-pfepyvaw 138 1 The the DT cord-011302-pfepyvaw 138 2 efficacy efficacy NN cord-011302-pfepyvaw 138 3 of of IN cord-011302-pfepyvaw 138 4 dexamethasone dexamethasone NN cord-011302-pfepyvaw 138 5 on on IN cord-011302-pfepyvaw 138 6 reduction reduction NN cord-011302-pfepyvaw 138 7 in in IN cord-011302-pfepyvaw 138 8 the the DT cord-011302-pfepyvaw 138 9 reoperation reoperation NN cord-011302-pfepyvaw 138 10 rate rate NN cord-011302-pfepyvaw 138 11 of of IN cord-011302-pfepyvaw 138 12 chronic chronic JJ cord-011302-pfepyvaw 138 13 subdural subdural JJ cord-011302-pfepyvaw 138 14 hematomathe hematomathe NNP cord-011302-pfepyvaw 138 15 DRESH DRESH NNP cord-011302-pfepyvaw 138 16 study study NN cord-011302-pfepyvaw 138 17 : : : cord-011302-pfepyvaw 138 18 straightforward straightforward JJ cord-011302-pfepyvaw 138 19 study study NN cord-011302-pfepyvaw 138 20 protocol protocol NN cord-011302-pfepyvaw 138 21 for for IN cord-011302-pfepyvaw 138 22 a a DT cord-011302-pfepyvaw 138 23 randomized randomized JJ cord-011302-pfepyvaw 138 24 controlled control VBN cord-011302-pfepyvaw 138 25 trial trial NN cord-011302-pfepyvaw 138 26 Prognosis prognosis NN cord-011302-pfepyvaw 138 27 of of IN cord-011302-pfepyvaw 138 28 acute acute JJ cord-011302-pfepyvaw 138 29 subdural subdural JJ cord-011302-pfepyvaw 138 30 hematoma hematoma NN cord-011302-pfepyvaw 138 31 in in IN cord-011302-pfepyvaw 138 32 the the DT cord-011302-pfepyvaw 138 33 elderly elderly JJ cord-011302-pfepyvaw 138 34 : : : cord-011302-pfepyvaw 138 35 a a DT cord-011302-pfepyvaw 138 36 systematic systematic JJ cord-011302-pfepyvaw 138 37 review review NN cord-011302-pfepyvaw 138 38 Are be VBP cord-011302-pfepyvaw 138 39 the the DT cord-011302-pfepyvaw 138 40 frail frail JJ cord-011302-pfepyvaw 138 41 destined destine VBN cord-011302-pfepyvaw 138 42 to to TO cord-011302-pfepyvaw 138 43 fail fail VB cord-011302-pfepyvaw 138 44 ? ? . cord-011302-pfepyvaw 139 1 Frailty frailty NN cord-011302-pfepyvaw 139 2 index index NN cord-011302-pfepyvaw 139 3 as as IN cord-011302-pfepyvaw 139 4 predictor predictor NN cord-011302-pfepyvaw 139 5 of of IN cord-011302-pfepyvaw 139 6 surgical surgical JJ cord-011302-pfepyvaw 139 7 morbidity morbidity NN cord-011302-pfepyvaw 139 8 and and CC cord-011302-pfepyvaw 139 9 mortality mortality NN cord-011302-pfepyvaw 139 10 in in IN cord-011302-pfepyvaw 139 11 the the DT cord-011302-pfepyvaw 139 12 elderly elderly JJ cord-011302-pfepyvaw 139 13 Untangling untangle VBG cord-011302-pfepyvaw 139 14 the the DT cord-011302-pfepyvaw 139 15 concepts concept NNS cord-011302-pfepyvaw 139 16 of of IN cord-011302-pfepyvaw 139 17 disability disability NN cord-011302-pfepyvaw 139 18 , , , cord-011302-pfepyvaw 139 19 frailty frailty NN cord-011302-pfepyvaw 139 20 , , , cord-011302-pfepyvaw 139 21 and and CC cord-011302-pfepyvaw 139 22 comorbidity comorbidity NN cord-011302-pfepyvaw 139 23 : : : cord-011302-pfepyvaw 139 24 implications implication NNS cord-011302-pfepyvaw 139 25 for for IN cord-011302-pfepyvaw 139 26 improved improve VBN cord-011302-pfepyvaw 139 27 targeting targeting NN cord-011302-pfepyvaw 139 28 and and CC cord-011302-pfepyvaw 139 29 care care VB cord-011302-pfepyvaw 139 30 Geriatric geriatric JJ cord-011302-pfepyvaw 139 31 traumatic traumatic JJ cord-011302-pfepyvaw 139 32 brain brain NN cord-011302-pfepyvaw 139 33 injury injury NN cord-011302-pfepyvaw 139 34 : : : cord-011302-pfepyvaw 139 35 epidemiology epidemiology NN cord-011302-pfepyvaw 139 36 , , , cord-011302-pfepyvaw 139 37 outcomes outcome NNS cord-011302-pfepyvaw 139 38 , , , cord-011302-pfepyvaw 139 39 knowledge knowledge NN cord-011302-pfepyvaw 139 40 gaps gap NNS cord-011302-pfepyvaw 139 41 , , , cord-011302-pfepyvaw 139 42 and and CC cord-011302-pfepyvaw 139 43 future future JJ cord-011302-pfepyvaw 139 44 directions direction NNS cord-011302-pfepyvaw 139 45 Steroids steroid NNS cord-011302-pfepyvaw 139 46 in in IN cord-011302-pfepyvaw 139 47 chronic chronic JJ cord-011302-pfepyvaw 139 48 subdural subdural JJ cord-011302-pfepyvaw 139 49 hematomas hematoma NNS cord-011302-pfepyvaw 139 50 ( ( -LRB- cord-011302-pfepyvaw 139 51 SUCRE SUCRE NNP cord-011302-pfepyvaw 139 52 trial trial NN cord-011302-pfepyvaw 139 53 ) ) -RRB- cord-011302-pfepyvaw 139 54 : : : cord-011302-pfepyvaw 139 55 study study NN cord-011302-pfepyvaw 139 56 protocol protocol NN cord-011302-pfepyvaw 139 57 for for IN cord-011302-pfepyvaw 139 58 a a DT cord-011302-pfepyvaw 139 59 randomized randomized JJ cord-011302-pfepyvaw 139 60 controlled control VBN cord-011302-pfepyvaw 139 61 trial trial NN cord-011302-pfepyvaw 139 62 Trial Trial NNP cord-011302-pfepyvaw 139 63 of of IN cord-011302-pfepyvaw 139 64 decompressive decompressive JJ cord-011302-pfepyvaw 139 65 craniectomy craniectomy NN cord-011302-pfepyvaw 139 66 for for IN cord-011302-pfepyvaw 139 67 traumatic traumatic JJ cord-011302-pfepyvaw 139 68 intracranial intracranial JJ cord-011302-pfepyvaw 139 69 hypertension hypertension NN cord-011302-pfepyvaw 139 70 International International NNP cord-011302-pfepyvaw 139 71 Mission Mission NNP cord-011302-pfepyvaw 139 72 for for IN cord-011302-pfepyvaw 139 73 Prognosis Prognosis NNP cord-011302-pfepyvaw 139 74 and and CC cord-011302-pfepyvaw 139 75 Analysis Analysis NNP cord-011302-pfepyvaw 139 76 of of IN cord-011302-pfepyvaw 139 77 Clinical Clinical NNP cord-011302-pfepyvaw 139 78 Trials Trials NNPS cord-011302-pfepyvaw 139 79 in in IN cord-011302-pfepyvaw 139 80 TBI TBI NNP cord-011302-pfepyvaw 139 81 ( ( -LRB- cord-011302-pfepyvaw 139 82 2020 2020 CD cord-011302-pfepyvaw 139 83 ) ) -RRB- cord-011302-pfepyvaw 140 1 IMPACT IMPACT NNP cord-011302-pfepyvaw 141 1 Prognostic prognostic JJ cord-011302-pfepyvaw 141 2 calculator calculator NN cord-011302-pfepyvaw 141 3 Aneurysm Aneurysm NNP cord-011302-pfepyvaw 141 4 occlusion occlusion NN cord-011302-pfepyvaw 141 5 in in IN cord-011302-pfepyvaw 141 6 elderly elderly JJ cord-011302-pfepyvaw 141 7 patients patient NNS cord-011302-pfepyvaw 141 8 with with IN cord-011302-pfepyvaw 141 9 aneurysmal aneurysmal NNP cord-011302-pfepyvaw 141 10 subarachnoid subarachnoid NN cord-011302-pfepyvaw 141 11 haemorrhage haemorrhage NN cord-011302-pfepyvaw 141 12 : : : cord-011302-pfepyvaw 141 13 a a DT cord-011302-pfepyvaw 141 14 cost cost NN cord-011302-pfepyvaw 141 15 - - HYPH cord-011302-pfepyvaw 141 16 utility utility NN cord-011302-pfepyvaw 141 17 analysis analysis NN cord-011302-pfepyvaw 141 18 Dexamethasone Dexamethasone NNP cord-011302-pfepyvaw 141 19 for for IN cord-011302-pfepyvaw 141 20 adult adult NN cord-011302-pfepyvaw 141 21 patients patient NNS cord-011302-pfepyvaw 141 22 with with IN cord-011302-pfepyvaw 141 23 a a DT cord-011302-pfepyvaw 141 24 symptomatic symptomatic JJ cord-011302-pfepyvaw 141 25 chronic chronic JJ cord-011302-pfepyvaw 141 26 subdural subdural JJ cord-011302-pfepyvaw 141 27 haematoma haematoma NN cord-011302-pfepyvaw 141 28 ( ( -LRB- cord-011302-pfepyvaw 141 29 Dex Dex NNP cord-011302-pfepyvaw 141 30 - - HYPH cord-011302-pfepyvaw 141 31 CSDH CSDH NNP cord-011302-pfepyvaw 141 32 ) ) -RRB- cord-011302-pfepyvaw 141 33 trial trial NN cord-011302-pfepyvaw 141 34 : : : cord-011302-pfepyvaw 141 35 study study NN cord-011302-pfepyvaw 141 36 protocol protocol NN cord-011302-pfepyvaw 141 37 for for IN cord-011302-pfepyvaw 141 38 a a DT cord-011302-pfepyvaw 141 39 randomised randomised JJ cord-011302-pfepyvaw 141 40 controlled control VBN cord-011302-pfepyvaw 141 41 trial trial NN cord-011302-pfepyvaw 142 1 Do do VB cord-011302-pfepyvaw 142 2 age age NN cord-011302-pfepyvaw 142 3 and and CC cord-011302-pfepyvaw 142 4 anticoagulants anticoagulant NNS cord-011302-pfepyvaw 142 5 affect affect VBP cord-011302-pfepyvaw 142 6 the the DT cord-011302-pfepyvaw 142 7 natural natural JJ cord-011302-pfepyvaw 142 8 history history NN cord-011302-pfepyvaw 142 9 of of IN cord-011302-pfepyvaw 142 10 acute acute JJ cord-011302-pfepyvaw 142 11 subdural subdural JJ cord-011302-pfepyvaw 142 12 hematomas hematoma NNS cord-011302-pfepyvaw 142 13 ? ? . cord-011302-pfepyvaw 143 1 The the DT cord-011302-pfepyvaw 143 2 barrow barrow NN cord-011302-pfepyvaw 143 3 ruptured rupture VBD cord-011302-pfepyvaw 143 4 aneurysm aneurysm NN cord-011302-pfepyvaw 143 5 Early early JJ cord-011302-pfepyvaw 143 6 surgery surgery NN cord-011302-pfepyvaw 143 7 versus versus IN cord-011302-pfepyvaw 143 8 initial initial JJ cord-011302-pfepyvaw 143 9 conservative conservative JJ cord-011302-pfepyvaw 143 10 treatment treatment NN cord-011302-pfepyvaw 143 11 in in IN cord-011302-pfepyvaw 143 12 patients patient NNS cord-011302-pfepyvaw 143 13 with with IN cord-011302-pfepyvaw 143 14 spontaneous spontaneous JJ cord-011302-pfepyvaw 143 15 supratentorial supratentorial NNP cord-011302-pfepyvaw 143 16 intracerebral intracerebral NNP cord-011302-pfepyvaw 143 17 haematomas haematomas NNP cord-011302-pfepyvaw 143 18 in in IN cord-011302-pfepyvaw 143 19 the the DT cord-011302-pfepyvaw 143 20 International International NNP cord-011302-pfepyvaw 143 21 Surgical Surgical NNP cord-011302-pfepyvaw 143 22 Trial Trial NNP cord-011302-pfepyvaw 143 23 in in IN cord-011302-pfepyvaw 143 24 Intracerebral Intracerebral NNP cord-011302-pfepyvaw 143 25 Haemorrhage Haemorrhage NNP cord-011302-pfepyvaw 143 26 ( ( -LRB- cord-011302-pfepyvaw 143 27 STICH STICH NNP cord-011302-pfepyvaw 143 28 ) ) -RRB- cord-011302-pfepyvaw 143 29 : : : cord-011302-pfepyvaw 144 1 a a DT cord-011302-pfepyvaw 144 2 randomised randomised JJ cord-011302-pfepyvaw 144 3 trial trial NN cord-011302-pfepyvaw 144 4 Early early JJ cord-011302-pfepyvaw 144 5 surgery surgery NN cord-011302-pfepyvaw 144 6 versus versus IN cord-011302-pfepyvaw 144 7 initial initial JJ cord-011302-pfepyvaw 144 8 conservative conservative JJ cord-011302-pfepyvaw 144 9 treatment treatment NN cord-011302-pfepyvaw 144 10 in in IN cord-011302-pfepyvaw 144 11 patients patient NNS cord-011302-pfepyvaw 144 12 with with IN cord-011302-pfepyvaw 144 13 spontaneous spontaneous JJ cord-011302-pfepyvaw 144 14 supratentorial supratentorial NNP cord-011302-pfepyvaw 144 15 lobar lobar NNP cord-011302-pfepyvaw 144 16 intracerebral intracerebral NNP cord-011302-pfepyvaw 144 17 haematomas haematomas NNP cord-011302-pfepyvaw 144 18 ( ( -LRB- cord-011302-pfepyvaw 144 19 STICH STICH NNP cord-011302-pfepyvaw 144 20 II II NNP cord-011302-pfepyvaw 144 21 ) ) -RRB- cord-011302-pfepyvaw 144 22 : : : cord-011302-pfepyvaw 144 23 a a DT cord-011302-pfepyvaw 144 24 randomised randomised JJ cord-011302-pfepyvaw 144 25 trial trial NN cord-011302-pfepyvaw 144 26 Dexamethasone Dexamethasone NNP cord-011302-pfepyvaw 144 27 therapy therapy NN cord-011302-pfepyvaw 144 28 versus versus IN cord-011302-pfepyvaw 144 29 surgery surgery NN cord-011302-pfepyvaw 144 30 for for IN cord-011302-pfepyvaw 144 31 chronic chronic JJ cord-011302-pfepyvaw 144 32 subdural subdural JJ cord-011302-pfepyvaw 144 33 haematoma haematoma NN cord-011302-pfepyvaw 144 34 ( ( -LRB- cord-011302-pfepyvaw 144 35 DECSA DECSA NNP cord-011302-pfepyvaw 144 36 trial trial NN cord-011302-pfepyvaw 144 37 ) ) -RRB- cord-011302-pfepyvaw 144 38 : : : cord-011302-pfepyvaw 144 39 study study NN cord-011302-pfepyvaw 144 40 protocol protocol NN cord-011302-pfepyvaw 144 41 for for IN cord-011302-pfepyvaw 144 42 a a DT cord-011302-pfepyvaw 144 43 randomised randomised JJ cord-011302-pfepyvaw 144 44 controlled control VBN cord-011302-pfepyvaw 144 45 trial trial NN cord-011302-pfepyvaw 144 46 International International NNP cord-011302-pfepyvaw 144 47 Subarachnoid Subarachnoid NNP cord-011302-pfepyvaw 144 48 Aneurysm Aneurysm NNP cord-011302-pfepyvaw 144 49 Trial Trial NNP cord-011302-pfepyvaw 144 50 ( ( -LRB- cord-011302-pfepyvaw 144 51 ISAT ISAT NNP cord-011302-pfepyvaw 144 52 ) ) -RRB- cord-011302-pfepyvaw 144 53 of of IN cord-011302-pfepyvaw 144 54 neurosurgical neurosurgical JJ cord-011302-pfepyvaw 144 55 clipping clipping NN cord-011302-pfepyvaw 144 56 versus versus IN cord-011302-pfepyvaw 144 57 endovascular endovascular JJ cord-011302-pfepyvaw 144 58 coiling coiling NN cord-011302-pfepyvaw 144 59 in in IN cord-011302-pfepyvaw 144 60 2143 2143 CD cord-011302-pfepyvaw 144 61 patients patient NNS cord-011302-pfepyvaw 144 62 with with IN cord-011302-pfepyvaw 144 63 ruptured ruptured JJ cord-011302-pfepyvaw 144 64 intracranial intracranial JJ cord-011302-pfepyvaw 144 65 aneurysms aneurysm NNS cord-011302-pfepyvaw 144 66 : : : cord-011302-pfepyvaw 144 67 a a DT cord-011302-pfepyvaw 144 68 randomised randomised JJ cord-011302-pfepyvaw 144 69 trial trial NN cord-011302-pfepyvaw 144 70 National National NNP cord-011302-pfepyvaw 144 71 Institute Institute NNP cord-011302-pfepyvaw 144 72 for for IN cord-011302-pfepyvaw 144 73 Health Health NNP cord-011302-pfepyvaw 144 74 and and CC cord-011302-pfepyvaw 144 75 Clinical Clinical NNP cord-011302-pfepyvaw 144 76 Excellence Excellence NNP cord-011302-pfepyvaw 144 77 ( ( -LRB- cord-011302-pfepyvaw 144 78 NICE NICE NNP cord-011302-pfepyvaw 144 79 ) ) -RRB- cord-011302-pfepyvaw 144 80 ( ( -LRB- cord-011302-pfepyvaw 144 81 2014 2014 CD cord-011302-pfepyvaw 144 82 ) ) -RRB- cord-011302-pfepyvaw 145 1 Head Head NNP cord-011302-pfepyvaw 145 2 injury injury NN cord-011302-pfepyvaw 145 3 : : : cord-011302-pfepyvaw 145 4 assessment assessment NN cord-011302-pfepyvaw 145 5 and and CC cord-011302-pfepyvaw 145 6 early early JJ cord-011302-pfepyvaw 145 7 management management NN cord-011302-pfepyvaw 145 8 clinical clinical JJ cord-011302-pfepyvaw 145 9 guidelines guideline NNS cord-011302-pfepyvaw 146 1 [ [ -LRB- cord-011302-pfepyvaw 146 2 CG176 CG176 NNP cord-011302-pfepyvaw 146 3 Subarachnoid Subarachnoid NNP cord-011302-pfepyvaw 146 4 haemorrhage haemorrhage NN cord-011302-pfepyvaw 146 5 in in IN cord-011302-pfepyvaw 146 6 patients patient NNS cord-011302-pfepyvaw 146 7 % % NN cord-011302-pfepyvaw 146 8 3e 3e NNP cord-011302-pfepyvaw 146 9 or or CC cord-011302-pfepyvaw 146 10 = = SYM cord-011302-pfepyvaw 146 11 75 75 CD cord-011302-pfepyvaw 146 12 years year NNS cord-011302-pfepyvaw 146 13 : : : cord-011302-pfepyvaw 146 14 clinical clinical JJ cord-011302-pfepyvaw 146 15 course course NN cord-011302-pfepyvaw 146 16 , , , cord-011302-pfepyvaw 146 17 treatment treatment NN cord-011302-pfepyvaw 146 18 and and CC cord-011302-pfepyvaw 146 19 outcome outcome NN cord-011302-pfepyvaw 147 1 The the DT cord-011302-pfepyvaw 147 2 impact impact NN cord-011302-pfepyvaw 147 3 of of IN cord-011302-pfepyvaw 147 4 pre pre JJ cord-011302-pfepyvaw 147 5 - - JJ cord-011302-pfepyvaw 147 6 operative operative JJ cord-011302-pfepyvaw 147 7 comprehensive comprehensive JJ cord-011302-pfepyvaw 147 8 geriatric geriatric JJ cord-011302-pfepyvaw 147 9 assessment assessment NN cord-011302-pfepyvaw 147 10 on on IN cord-011302-pfepyvaw 147 11 postoperative postoperative JJ cord-011302-pfepyvaw 147 12 outcomes outcome NNS cord-011302-pfepyvaw 147 13 in in IN cord-011302-pfepyvaw 147 14 older old JJR cord-011302-pfepyvaw 147 15 patients patient NNS cord-011302-pfepyvaw 147 16 undergoing undergo VBG cord-011302-pfepyvaw 147 17 scheduled schedule VBN cord-011302-pfepyvaw 147 18 surgery surgery NN cord-011302-pfepyvaw 147 19 : : : cord-011302-pfepyvaw 147 20 a a DT cord-011302-pfepyvaw 147 21 systematic systematic JJ cord-011302-pfepyvaw 147 22 review review NN cord-011302-pfepyvaw 147 23 A a DT cord-011302-pfepyvaw 147 24 global global JJ cord-011302-pfepyvaw 147 25 clinical clinical JJ cord-011302-pfepyvaw 147 26 measure measure NN cord-011302-pfepyvaw 147 27 of of IN cord-011302-pfepyvaw 147 28 fitness fitness NN cord-011302-pfepyvaw 147 29 and and CC cord-011302-pfepyvaw 147 30 frailty frailty NN cord-011302-pfepyvaw 147 31 in in IN cord-011302-pfepyvaw 147 32 elderly elderly JJ cord-011302-pfepyvaw 147 33 people people NNS cord-011302-pfepyvaw 147 34 International international JJ cord-011302-pfepyvaw 147 35 subarachnoid subarachnoid NN cord-011302-pfepyvaw 147 36 aneurysm aneurysm NN cord-011302-pfepyvaw 147 37 trial trial NN cord-011302-pfepyvaw 147 38 of of IN cord-011302-pfepyvaw 147 39 neurosurgical neurosurgical JJ cord-011302-pfepyvaw 147 40 clipping clipping NN cord-011302-pfepyvaw 147 41 versus versus IN cord-011302-pfepyvaw 147 42 endovascular endovascular JJ cord-011302-pfepyvaw 147 43 coiling coil VBG cord-011302-pfepyvaw 147 44 Use use NN cord-011302-pfepyvaw 147 45 of of IN cord-011302-pfepyvaw 147 46 drains drain NNS cord-011302-pfepyvaw 147 47 versus versus IN cord-011302-pfepyvaw 147 48 no no DT cord-011302-pfepyvaw 147 49 drains drain NNS cord-011302-pfepyvaw 147 50 after after IN cord-011302-pfepyvaw 147 51 burr burr NN cord-011302-pfepyvaw 147 52 - - HYPH cord-011302-pfepyvaw 147 53 hole hole NN cord-011302-pfepyvaw 147 54 evacuation evacuation NN cord-011302-pfepyvaw 147 55 of of IN cord-011302-pfepyvaw 147 56 chronic chronic JJ cord-011302-pfepyvaw 147 57 subdural subdural JJ cord-011302-pfepyvaw 147 58 haematoma haematoma NN cord-011302-pfepyvaw 147 59 : : : cord-011302-pfepyvaw 147 60 a a DT cord-011302-pfepyvaw 147 61 randomised randomised JJ cord-011302-pfepyvaw 147 62 controlled control VBN cord-011302-pfepyvaw 147 63 trial trial NN cord-011302-pfepyvaw 147 64 Minimally minimally RB cord-011302-pfepyvaw 147 65 invasive invasive JJ cord-011302-pfepyvaw 147 66 surgery surgery NN cord-011302-pfepyvaw 147 67 for for IN cord-011302-pfepyvaw 147 68 intracerebral intracerebral JJ cord-011302-pfepyvaw 147 69 hemorrhage hemorrhage NN cord-011302-pfepyvaw 148 1 Aneurysmal aneurysmal JJ cord-011302-pfepyvaw 148 2 subarachnoid subarachnoid NN cord-011302-pfepyvaw 148 3 hemorrhage hemorrhage NN cord-011302-pfepyvaw 148 4 in in IN cord-011302-pfepyvaw 148 5 elderly elderly JJ cord-011302-pfepyvaw 148 6 patients patient NNS cord-011302-pfepyvaw 148 7 : : : cord-011302-pfepyvaw 148 8 long long JJ cord-011302-pfepyvaw 148 9 - - HYPH cord-011302-pfepyvaw 148 10 term term NN cord-011302-pfepyvaw 148 11 outcome outcome NN cord-011302-pfepyvaw 148 12 and and CC cord-011302-pfepyvaw 148 13 prognostic prognostic JJ cord-011302-pfepyvaw 148 14 factors factor NNS cord-011302-pfepyvaw 148 15 in in IN cord-011302-pfepyvaw 148 16 an an DT cord-011302-pfepyvaw 148 17 interdisciplinary interdisciplinary JJ cord-011302-pfepyvaw 148 18 treatment treatment NN cord-011302-pfepyvaw 148 19 approach approach NN cord-011302-pfepyvaw 148 20 Importance importance NN cord-011302-pfepyvaw 148 21 of of IN cord-011302-pfepyvaw 148 22 frailty frailty NN cord-011302-pfepyvaw 148 23 evaluation evaluation NN cord-011302-pfepyvaw 148 24 in in IN cord-011302-pfepyvaw 148 25 the the DT cord-011302-pfepyvaw 148 26 prediction prediction NN cord-011302-pfepyvaw 148 27 of of IN cord-011302-pfepyvaw 148 28 the the DT cord-011302-pfepyvaw 148 29 prognosis prognosis NN cord-011302-pfepyvaw 148 30 of of IN cord-011302-pfepyvaw 148 31 patients patient NNS cord-011302-pfepyvaw 148 32 with with IN cord-011302-pfepyvaw 148 33 chronic chronic JJ cord-011302-pfepyvaw 148 34 subdural subdural JJ cord-011302-pfepyvaw 148 35 hematoma hematoma NN cord-011302-pfepyvaw 148 36 Oertel Oertel NNP cord-011302-pfepyvaw 148 37 Matthias Matthias NNP cord-011302-pfepyvaw 148 38 F F NNP cord-011302-pfepyvaw 148 39 ( ( -LRB- cord-011302-pfepyvaw 148 40 2012 2012 CD cord-011302-pfepyvaw 148 41 ) ) -RRB- cord-011302-pfepyvaw 149 1 Intracerebral Intracerebral NNP cord-011302-pfepyvaw 149 2 hemorrhage hemorrhage NN cord-011302-pfepyvaw 149 3 in in IN cord-011302-pfepyvaw 149 4 the the DT cord-011302-pfepyvaw 149 5 Very Very NNP cord-011302-pfepyvaw 149 6 Old Old NNP cord-011302-pfepyvaw 149 7 Endovascular Endovascular NNP cord-011302-pfepyvaw 149 8 treatment treatment NN cord-011302-pfepyvaw 149 9 of of IN cord-011302-pfepyvaw 149 10 intracranial intracranial JJ cord-011302-pfepyvaw 149 11 aneurysms aneurysm NNS cord-011302-pfepyvaw 149 12 in in IN cord-011302-pfepyvaw 149 13 elderly elderly JJ cord-011302-pfepyvaw 149 14 patients patient NNS cord-011302-pfepyvaw 149 15 Efficacy Efficacy NNP cord-011302-pfepyvaw 149 16 and and CC cord-011302-pfepyvaw 149 17 safety safety NN cord-011302-pfepyvaw 149 18 of of IN cord-011302-pfepyvaw 149 19 minimal minimal JJ cord-011302-pfepyvaw 149 20 invasive invasive JJ cord-011302-pfepyvaw 149 21 surgery surgery NN cord-011302-pfepyvaw 149 22 treatment treatment NN cord-011302-pfepyvaw 149 23 in in IN cord-011302-pfepyvaw 149 24 hypertensive hypertensive JJ cord-011302-pfepyvaw 149 25 intracerebral intracerebral JJ cord-011302-pfepyvaw 149 26 hemorrhage hemorrhage NN cord-011302-pfepyvaw 149 27 : : : cord-011302-pfepyvaw 149 28 a a DT cord-011302-pfepyvaw 149 29 systematic systematic JJ cord-011302-pfepyvaw 149 30 review review NN cord-011302-pfepyvaw 149 31 and and CC cord-011302-pfepyvaw 149 32 meta meta NNP cord-011302-pfepyvaw 149 33 - - HYPH cord-011302-pfepyvaw 149 34 analysis analysis NN cord-011302-pfepyvaw 150 1 The the DT cord-011302-pfepyvaw 150 2 MRC MRC NNP cord-011302-pfepyvaw 150 3 CRASH crash NN cord-011302-pfepyvaw 150 4 trial trial NN cord-011302-pfepyvaw 150 5 collaborators collaborator NNS cord-011302-pfepyvaw 150 6 ( ( -LRB- cord-011302-pfepyvaw 150 7 2020 2020 CD cord-011302-pfepyvaw 150 8 ) ) -RRB- cord-011302-pfepyvaw 151 1 Head Head NNP cord-011302-pfepyvaw 151 2 Injury Injury NNP cord-011302-pfepyvaw 151 3 Prognosis prognosis NN cord-011302-pfepyvaw 151 4 , , , cord-011302-pfepyvaw 151 5 CRASH CRASH NNP cord-011302-pfepyvaw 151 6 Preoperative Preoperative NNP cord-011302-pfepyvaw 151 7 frailty frailty NN cord-011302-pfepyvaw 151 8 score score NN cord-011302-pfepyvaw 151 9 for for IN cord-011302-pfepyvaw 151 10 30-day 30-day CD cord-011302-pfepyvaw 151 11 morbidity morbidity NN cord-011302-pfepyvaw 151 12 and and CC cord-011302-pfepyvaw 151 13 mortality mortality NN cord-011302-pfepyvaw 151 14 after after IN cord-011302-pfepyvaw 151 15 cranial cranial NNP cord-011302-pfepyvaw 151 16 neurosurgery neurosurgery NNP cord-011302-pfepyvaw 151 17 Association Association NNP cord-011302-pfepyvaw 151 18 of of IN cord-011302-pfepyvaw 151 19 the the DT cord-011302-pfepyvaw 151 20 modified modify VBN cord-011302-pfepyvaw 151 21 frailty frailty NN cord-011302-pfepyvaw 151 22 index index NN cord-011302-pfepyvaw 151 23 with with IN cord-011302-pfepyvaw 151 24 30-day 30-day CD cord-011302-pfepyvaw 151 25 surgical surgical JJ cord-011302-pfepyvaw 151 26 readmission readmission NN cord-011302-pfepyvaw 151 27 Head Head NNP cord-011302-pfepyvaw 151 28 injury injury NN cord-011302-pfepyvaw 151 29 in in IN cord-011302-pfepyvaw 151 30 the the DT cord-011302-pfepyvaw 151 31 elderly elderly JJ cord-011302-pfepyvaw 152 1 : : : cord-011302-pfepyvaw 152 2 what what WP cord-011302-pfepyvaw 152 3 are be VBP cord-011302-pfepyvaw 152 4 the the DT cord-011302-pfepyvaw 152 5 outcomes outcome NNS cord-011302-pfepyvaw 152 6 of of IN cord-011302-pfepyvaw 152 7 neurosurgical neurosurgical JJ cord-011302-pfepyvaw 152 8 care care NN cord-011302-pfepyvaw 152 9 ? ? . cord-011302-pfepyvaw 153 1 Neurosurgical neurosurgical JJ cord-011302-pfepyvaw 153 2 care care NN cord-011302-pfepyvaw 153 3 in in IN cord-011302-pfepyvaw 153 4 the the DT cord-011302-pfepyvaw 153 5 elderly elderly JJ cord-011302-pfepyvaw 153 6 : : : cord-011302-pfepyvaw 154 1 increasing increase VBG cord-011302-pfepyvaw 154 2 demands demand NNS cord-011302-pfepyvaw 154 3 necessitate necessitate VBP cord-011302-pfepyvaw 154 4 future future JJ cord-011302-pfepyvaw 154 5 healthcare healthcare NN cord-011302-pfepyvaw 154 6 planning plan VBG cord-011302-pfepyvaw 154 7 Unruptured unruptured JJ cord-011302-pfepyvaw 154 8 intracranial intracranial JJ cord-011302-pfepyvaw 154 9 aneurysms aneurysm NNS cord-011302-pfepyvaw 154 10 : : : cord-011302-pfepyvaw 154 11 natural natural JJ cord-011302-pfepyvaw 154 12 history history NN cord-011302-pfepyvaw 154 13 , , , cord-011302-pfepyvaw 154 14 clinical clinical JJ cord-011302-pfepyvaw 154 15 outcome outcome NN cord-011302-pfepyvaw 154 16 , , , cord-011302-pfepyvaw 154 17 and and CC cord-011302-pfepyvaw 154 18 risks risk NNS cord-011302-pfepyvaw 154 19 of of IN cord-011302-pfepyvaw 154 20 surgical surgical JJ cord-011302-pfepyvaw 154 21 and and CC cord-011302-pfepyvaw 154 22 endovascular endovascular JJ cord-011302-pfepyvaw 154 23 treatment treatment NN cord-011302-pfepyvaw 154 24 Significant significant JJ cord-011302-pfepyvaw 154 25 increase increase NN cord-011302-pfepyvaw 154 26 in in IN cord-011302-pfepyvaw 154 27 acute acute JJ cord-011302-pfepyvaw 154 28 subdural subdural JJ cord-011302-pfepyvaw 154 29 hematoma hematoma NN cord-011302-pfepyvaw 154 30 in in IN cord-011302-pfepyvaw 154 31 octo octo NNP cord-011302-pfepyvaw 154 32 - - : cord-011302-pfepyvaw 154 33 and and CC cord-011302-pfepyvaw 154 34 nonagenarians nonagenarian NNS cord-011302-pfepyvaw 154 35 : : : cord-011302-pfepyvaw 154 36 surgical surgical JJ cord-011302-pfepyvaw 154 37 treatment treatment NN cord-011302-pfepyvaw 154 38 , , , cord-011302-pfepyvaw 154 39 functional functional JJ cord-011302-pfepyvaw 154 40 outcome outcome NN cord-011302-pfepyvaw 154 41 , , , cord-011302-pfepyvaw 154 42 and and CC cord-011302-pfepyvaw 154 43 predictors predictor NNS cord-011302-pfepyvaw 154 44 in in IN cord-011302-pfepyvaw 154 45 this this DT cord-011302-pfepyvaw 154 46 patient patient JJ cord-011302-pfepyvaw 154 47 cohort cohort NN cord-011302-pfepyvaw 154 48 Acute acute JJ cord-011302-pfepyvaw 154 49 subdural subdural JJ cord-011302-pfepyvaw 154 50 hematoma hematoma NN cord-011302-pfepyvaw 154 51 in in IN cord-011302-pfepyvaw 154 52 patients patient NNS cord-011302-pfepyvaw 154 53 on on IN cord-011302-pfepyvaw 154 54 oral oral JJ cord-011302-pfepyvaw 154 55 anticoagulant anticoagulant NN cord-011302-pfepyvaw 154 56 therapy therapy NN cord-011302-pfepyvaw 154 57 : : : cord-011302-pfepyvaw 154 58 management management NN cord-011302-pfepyvaw 154 59 and and CC cord-011302-pfepyvaw 154 60 outcome outcome NN cord-011302-pfepyvaw 155 1 The the DT cord-011302-pfepyvaw 155 2 modified modify VBN cord-011302-pfepyvaw 155 3 frailty frailty NN cord-011302-pfepyvaw 155 4 index index NN cord-011302-pfepyvaw 155 5 and and CC cord-011302-pfepyvaw 155 6 30-day 30-day CD cord-011302-pfepyvaw 155 7 adverse adverse JJ cord-011302-pfepyvaw 155 8 events event NNS cord-011302-pfepyvaw 155 9 in in IN cord-011302-pfepyvaw 155 10 oncologic oncologic NNP cord-011302-pfepyvaw 155 11 neurosurgery neurosurgery NNP cord-011302-pfepyvaw 156 1 A a DT cord-011302-pfepyvaw 156 2 prognostic prognostic JJ cord-011302-pfepyvaw 156 3 model model NN cord-011302-pfepyvaw 156 4 for for IN cord-011302-pfepyvaw 156 5 early early JJ cord-011302-pfepyvaw 156 6 post post JJ cord-011302-pfepyvaw 156 7 - - JJ cord-011302-pfepyvaw 156 8 treatment treatment JJ cord-011302-pfepyvaw 156 9 outcome outcome NN cord-011302-pfepyvaw 156 10 of of IN cord-011302-pfepyvaw 156 11 elderly elderly JJ cord-011302-pfepyvaw 156 12 patients patient NNS cord-011302-pfepyvaw 156 13 with with IN cord-011302-pfepyvaw 156 14 aneurysmal aneurysmal NNP cord-011302-pfepyvaw 156 15 subarachnoid subarachnoid NN cord-011302-pfepyvaw 156 16 hemorrhage hemorrhage NN