id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-009089-hmfd0xws	Stein, H.	IDENTIFICATION OF A T CELL LYMPHOMA CATEGORY DERIVED FROM INTESTINAL-MUCOSA-ASSOCIATED T CELLS	1988-11-05		.txt	text/plain	1305	68	47	2 cases of precursor T cell lymphoma and 37 cases of peripheral T cell lymphoma were investigated for their reactivity with the monoclonal antibody (mAb) HML-1, which recognises human intestinal T lymphocytes but not lymph-node T cells. The HML-1(+) lymphoma was the only tumour that was primarily localised in the epithelium and lamina propria of the small intestine, and was associated with ulcerative jejunitis and coeliac disease. This suggestion has been confirmed by generation of a monoclonal antibody (mAb), designated HML-1, that reacts with nearly all intraepithelial T cells and 40% of the lamina propria T cells of the intestine but with only occasional cells in lymph nodes, tonsils, blood, or skin.6 If the mucosa-associated T cells give rise to lymphomas, these should be identifiable with the mAb HML-1. At the first meeting of the European Society for Haematopathology (April 14, 1988) Isaacson reported another case of intestinal T cell lymphoma associated with coeliac disease that was reactive with the HML-1 antibody.	./cache/cord-009089-hmfd0xws.txt	./txt/cord-009089-hmfd0xws.txt