id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-274313-mrvk9r4w	Li, Hui	SARS-CoV-2 and viral sepsis: observations and hypotheses	2020-04-17		.txt	text/plain	2428	138	44	With evidence collected from autopsy studies on COVID-19 and basic science research on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-CoV, we have put forward several hypotheses about SARS-CoV-2 pathogenesis after multiple rounds of discussion among basic science researchers, pathologists, and clinicians working on COVID-19. Whether SARS-CoV-2 is able to directly attack vascular endothelial cells expressing high levels of ACE2, 13 and then lead to abnormal coagulation and sepsis, still needs to be explored. On the basis of observations from COVID-19 patients, we hypothesise that in mild cases, resident macrophages initiating lung inflammatory responses were able to contain the virus after SARS-CoV-2 infection; both innate and adaptive immune responses were efficiently established to curb the viral replication so that the patient would recover quickly. Meanwhile, the direct attack on other organs by disseminated SARS-CoV-2, the immune pathogenesis caused by the systemic cytokine storm, and the microcirculation dysfunctions together lead to viral sepsis (figure).	./cache/cord-274313-mrvk9r4w.txt	./txt/cord-274313-mrvk9r4w.txt