id sid tid token lemma pos cord-329200-o5hxpl8f 1 1 key key JJ cord-329200-o5hxpl8f 2 1 : : : cord-329200-o5hxpl8f 2 2 cord-329200-o5hxpl8f cord-329200-o5hxpl8f NNP cord-329200-o5hxpl8f 2 3 authors author NNS cord-329200-o5hxpl8f 2 4 : : : cord-329200-o5hxpl8f 2 5 Houlihan Houlihan NNP cord-329200-o5hxpl8f 2 6 , , , cord-329200-o5hxpl8f 2 7 Catherine Catherine NNP cord-329200-o5hxpl8f 2 8 F F NNP cord-329200-o5hxpl8f 2 9 ; ; : cord-329200-o5hxpl8f 2 10 Beale Beale NNP cord-329200-o5hxpl8f 2 11 , , , cord-329200-o5hxpl8f 2 12 Rupert Rupert NNP cord-329200-o5hxpl8f 3 1 title title NN cord-329200-o5hxpl8f 3 2 : : : cord-329200-o5hxpl8f 4 1 The the DT cord-329200-o5hxpl8f 4 2 complexities complexity NNS cord-329200-o5hxpl8f 4 3 of of IN cord-329200-o5hxpl8f 4 4 SARS SARS NNP cord-329200-o5hxpl8f 4 5 - - HYPH cord-329200-o5hxpl8f 4 6 CoV-2 CoV-2 NNP cord-329200-o5hxpl8f 4 7 serology serology NN cord-329200-o5hxpl8f 4 8 date date NN cord-329200-o5hxpl8f 4 9 : : : cord-329200-o5hxpl8f 4 10 2020 2020 CD cord-329200-o5hxpl8f 4 11 - - HYPH cord-329200-o5hxpl8f 4 12 09 09 CD cord-329200-o5hxpl8f 4 13 - - SYM cord-329200-o5hxpl8f 4 14 23 23 CD cord-329200-o5hxpl8f 4 15 journal journal NN cord-329200-o5hxpl8f 4 16 : : : cord-329200-o5hxpl8f 5 1 Lancet Lancet NNP cord-329200-o5hxpl8f 5 2 Infect infect VB cord-329200-o5hxpl8f 5 3 Dis dis NN cord-329200-o5hxpl8f 5 4 DOI doi NN cord-329200-o5hxpl8f 6 1 : : : cord-329200-o5hxpl8f 6 2 10.1016 10.1016 CD cord-329200-o5hxpl8f 6 3 / / SYM cord-329200-o5hxpl8f 6 4 s1473 s1473 NN cord-329200-o5hxpl8f 6 5 - - NN cord-329200-o5hxpl8f 6 6 3099(20)30699-x 3099(20)30699-x CD cord-329200-o5hxpl8f 7 1 sha sha NNP cord-329200-o5hxpl8f 7 2 : : : cord-329200-o5hxpl8f 8 1 657ec714cc9cf2cc40639081c0b342b7cee54126 657ec714cc9cf2cc40639081c0b342b7cee54126 CD cord-329200-o5hxpl8f 9 1 doc_id doc_id CD cord-329200-o5hxpl8f 9 2 : : : cord-329200-o5hxpl8f 9 3 329200 329200 CD cord-329200-o5hxpl8f 9 4 cord_uid cord_uid NNS cord-329200-o5hxpl8f 9 5 : : : cord-329200-o5hxpl8f 10 1 o5hxpl8f o5hxpl8f NNP cord-329200-o5hxpl8f 10 2 nan nan NNP cord-329200-o5hxpl8f 10 3 Diagnosing diagnose VBG cord-329200-o5hxpl8f 10 4 previous previous JJ cord-329200-o5hxpl8f 10 5 infection infection NN cord-329200-o5hxpl8f 10 6 with with IN cord-329200-o5hxpl8f 10 7 respiratory respiratory JJ cord-329200-o5hxpl8f 10 8 viruses virus NNS cord-329200-o5hxpl8f 10 9 is be VBZ cord-329200-o5hxpl8f 10 10 challenging challenging JJ cord-329200-o5hxpl8f 10 11 . . . cord-329200-o5hxpl8f 11 1 Our -PRON- PRP$ cord-329200-o5hxpl8f 11 2 understanding understanding NN cord-329200-o5hxpl8f 11 3 of of IN cord-329200-o5hxpl8f 11 4 individual individual NN cord-329200-o5hxpl8f 11 5 and and CC cord-329200-o5hxpl8f 11 6 population population NN cord-329200-o5hxpl8f 11 7 - - HYPH cord-329200-o5hxpl8f 11 8 level level NN cord-329200-o5hxpl8f 11 9 immunity immunity NN cord-329200-o5hxpl8f 11 10 to to IN cord-329200-o5hxpl8f 11 11 severe severe JJ cord-329200-o5hxpl8f 11 12 acute acute JJ cord-329200-o5hxpl8f 11 13 respiratory respiratory JJ cord-329200-o5hxpl8f 11 14 syndrome syndrome NN cord-329200-o5hxpl8f 11 15 coronavirus coronavirus NN cord-329200-o5hxpl8f 11 16 2 2 CD cord-329200-o5hxpl8f 11 17 ( ( -LRB- cord-329200-o5hxpl8f 11 18 SARS SARS NNP cord-329200-o5hxpl8f 11 19 - - HYPH cord-329200-o5hxpl8f 11 20 CoV-2 CoV-2 NNP cord-329200-o5hxpl8f 11 21 ) ) -RRB- cord-329200-o5hxpl8f 11 22 remains remain VBZ cord-329200-o5hxpl8f 11 23 incomplete incomplete JJ cord-329200-o5hxpl8f 11 24 and and CC cord-329200-o5hxpl8f 11 25 developing develop VBG cord-329200-o5hxpl8f 11 26 reliable reliable JJ cord-329200-o5hxpl8f 11 27 serological serological JJ cord-329200-o5hxpl8f 11 28 assays assay NNS cord-329200-o5hxpl8f 11 29 to to TO cord-329200-o5hxpl8f 11 30 detect detect VB cord-329200-o5hxpl8f 11 31 previous previous JJ cord-329200-o5hxpl8f 11 32 infection infection NN cord-329200-o5hxpl8f 11 33 has have VBZ cord-329200-o5hxpl8f 11 34 been be VBN cord-329200-o5hxpl8f 11 35 an an DT cord-329200-o5hxpl8f 11 36 intense intense JJ cord-329200-o5hxpl8f 11 37 focus focus NN cord-329200-o5hxpl8f 11 38 of of IN cord-329200-o5hxpl8f 11 39 the the DT cord-329200-o5hxpl8f 11 40 global global JJ cord-329200-o5hxpl8f 11 41 scientific scientific JJ cord-329200-o5hxpl8f 11 42 effort effort NN cord-329200-o5hxpl8f 11 43 . . . cord-329200-o5hxpl8f 12 1 For for IN cord-329200-o5hxpl8f 12 2 public public JJ cord-329200-o5hxpl8f 12 3 health health NN cord-329200-o5hxpl8f 12 4 planning planning NN cord-329200-o5hxpl8f 12 5 we -PRON- PRP cord-329200-o5hxpl8f 12 6 need need VBP cord-329200-o5hxpl8f 12 7 scalable scalable JJ cord-329200-o5hxpl8f 12 8 assays assay NNS cord-329200-o5hxpl8f 12 9 validated validate VBN cord-329200-o5hxpl8f 12 10 against against IN cord-329200-o5hxpl8f 12 11 large large JJ cord-329200-o5hxpl8f 12 12 banks bank NNS cord-329200-o5hxpl8f 12 13 of of IN cord-329200-o5hxpl8f 12 14 samples sample NNS cord-329200-o5hxpl8f 12 15 from from IN cord-329200-o5hxpl8f 12 16 individuals individual NNS cord-329200-o5hxpl8f 12 17 who who WP cord-329200-o5hxpl8f 12 18 had have VBD cord-329200-o5hxpl8f 12 19 proven prove VBN cord-329200-o5hxpl8f 12 20 seasonal seasonal JJ cord-329200-o5hxpl8f 12 21 ( ( -LRB- cord-329200-o5hxpl8f 12 22 non non JJ cord-329200-o5hxpl8f 12 23 - - JJ cord-329200-o5hxpl8f 12 24 severe severe JJ cord-329200-o5hxpl8f 12 25 acute acute JJ cord-329200-o5hxpl8f 12 26 respiratory respiratory JJ cord-329200-o5hxpl8f 12 27 syndrome syndrome NN cord-329200-o5hxpl8f 12 28 ) ) -RRB- cord-329200-o5hxpl8f 12 29 coronaviruses coronaviruse NNS cord-329200-o5hxpl8f 12 30 and and CC cord-329200-o5hxpl8f 12 31 those those DT cord-329200-o5hxpl8f 12 32 who who WP cord-329200-o5hxpl8f 12 33 had have VBD cord-329200-o5hxpl8f 12 34 well well RB cord-329200-o5hxpl8f 12 35 characterised characterise VBN cord-329200-o5hxpl8f 12 36 symptomatic symptomatic JJ cord-329200-o5hxpl8f 12 37 and and CC cord-329200-o5hxpl8f 12 38 asymptomatic asymptomatic JJ cord-329200-o5hxpl8f 12 39 confirmed confirm VBN cord-329200-o5hxpl8f 12 40 SARS SARS NNP cord-329200-o5hxpl8f 12 41 - - HYPH cord-329200-o5hxpl8f 12 42 CoV-2 CoV-2 NNP cord-329200-o5hxpl8f 12 43 infection infection NN cord-329200-o5hxpl8f 12 44 . . . cord-329200-o5hxpl8f 13 1 False false JJ cord-329200-o5hxpl8f 13 2 - - HYPH cord-329200-o5hxpl8f 13 3 positive positive JJ cord-329200-o5hxpl8f 13 4 results result NNS cord-329200-o5hxpl8f 13 5 , , , cord-329200-o5hxpl8f 13 6 due due IN cord-329200-o5hxpl8f 13 7 to to IN cord-329200-o5hxpl8f 13 8 crossreactivity crossreactivity NN cord-329200-o5hxpl8f 13 9 with with IN cord-329200-o5hxpl8f 13 10 seasonal seasonal JJ cord-329200-o5hxpl8f 13 11 coronaviruses coronaviruse NNS cord-329200-o5hxpl8f 13 12 , , , cord-329200-o5hxpl8f 13 13 are be VBP cord-329200-o5hxpl8f 13 14 important important JJ cord-329200-o5hxpl8f 13 15 to to TO cord-329200-o5hxpl8f 13 16 avoid avoid VB cord-329200-o5hxpl8f 13 17 , , , cord-329200-o5hxpl8f 13 18 particularly particularly RB cord-329200-o5hxpl8f 13 19 if if IN cord-329200-o5hxpl8f 13 20 seropositive seropositive NNS cord-329200-o5hxpl8f 13 21 - - HYPH cord-329200-o5hxpl8f 13 22 individuals individual NNS cord-329200-o5hxpl8f 13 23 consider consider VBP cord-329200-o5hxpl8f 13 24 themselves -PRON- PRP cord-329200-o5hxpl8f 13 25 immune immune JJ cord-329200-o5hxpl8f 13 26 . . . cord-329200-o5hxpl8f 14 1 In in IN cord-329200-o5hxpl8f 14 2 The the DT cord-329200-o5hxpl8f 14 3 Lancet Lancet NNP cord-329200-o5hxpl8f 14 4 Infectious Infectious NNP cord-329200-o5hxpl8f 14 5 Diseases Diseases NNPS cord-329200-o5hxpl8f 14 6 , , , cord-329200-o5hxpl8f 14 7 the the DT cord-329200-o5hxpl8f 14 8 National National NNP cord-329200-o5hxpl8f 14 9 SARS SARS NNP cord-329200-o5hxpl8f 14 10 - - HYPH cord-329200-o5hxpl8f 14 11 CoV-2 CoV-2 NNP cord-329200-o5hxpl8f 14 12 Serology Serology NNP cord-329200-o5hxpl8f 14 13 Assay Assay NNP cord-329200-o5hxpl8f 14 14 Evaluation Evaluation NNP cord-329200-o5hxpl8f 14 15 Group Group NNP cord-329200-o5hxpl8f 14 16 1 1 CD cord-329200-o5hxpl8f 14 17 provide provide VBP cord-329200-o5hxpl8f 14 18 the the DT cord-329200-o5hxpl8f 14 19 first first JJ cord-329200-o5hxpl8f 14 20 large large JJ cord-329200-o5hxpl8f 14 21 comparative comparative JJ cord-329200-o5hxpl8f 14 22 investigation investigation NN cord-329200-o5hxpl8f 14 23 of of IN cord-329200-o5hxpl8f 14 24 the the DT cord-329200-o5hxpl8f 14 25 performance performance NN cord-329200-o5hxpl8f 14 26 of of IN cord-329200-o5hxpl8f 14 27 four four CD cord-329200-o5hxpl8f 14 28 widely widely RB cord-329200-o5hxpl8f 14 29 available available JJ cord-329200-o5hxpl8f 14 30 commercial commercial JJ cord-329200-o5hxpl8f 14 31 assays assay NNS cord-329200-o5hxpl8f 14 32 and and CC cord-329200-o5hxpl8f 14 33 a a DT cord-329200-o5hxpl8f 14 34 single single JJ cord-329200-o5hxpl8f 14 35 in in IN cord-329200-o5hxpl8f 14 36 - - HYPH cord-329200-o5hxpl8f 14 37 house house NN cord-329200-o5hxpl8f 14 38 assay assay NN cord-329200-o5hxpl8f 14 39 . . . cord-329200-o5hxpl8f 15 1 Antibody antibody NN cord-329200-o5hxpl8f 15 2 responses response NNS cord-329200-o5hxpl8f 15 3 to to IN cord-329200-o5hxpl8f 15 4 SARS SARS NNP cord-329200-o5hxpl8f 15 5 - - HYPH cord-329200-o5hxpl8f 15 6 CoV-2 CoV-2 NNP cord-329200-o5hxpl8f 15 7 are be VBP cord-329200-o5hxpl8f 15 8 predominantly predominantly RB cord-329200-o5hxpl8f 15 9 directed direct VBN cord-329200-o5hxpl8f 15 10 at at IN cord-329200-o5hxpl8f 15 11 the the DT cord-329200-o5hxpl8f 15 12 spike spike NN cord-329200-o5hxpl8f 15 13 glycoprotein glycoprotein NN cord-329200-o5hxpl8f 15 14 , , , cord-329200-o5hxpl8f 15 15 which which WDT cord-329200-o5hxpl8f 15 16 the the DT cord-329200-o5hxpl8f 15 17 virus virus NN cord-329200-o5hxpl8f 15 18 requires require VBZ cord-329200-o5hxpl8f 15 19 for for IN cord-329200-o5hxpl8f 15 20 entry entry NN cord-329200-o5hxpl8f 15 21 , , , cord-329200-o5hxpl8f 15 22 and and CC cord-329200-o5hxpl8f 15 23 the the DT cord-329200-o5hxpl8f 15 24 nucleocapsid nucleocapsid NNP cord-329200-o5hxpl8f 15 25 protein protein NN cord-329200-o5hxpl8f 15 26 , , , cord-329200-o5hxpl8f 15 27 which which WDT cord-329200-o5hxpl8f 15 28 binds bind VBZ cord-329200-o5hxpl8f 15 29 the the DT cord-329200-o5hxpl8f 15 30 viral viral JJ cord-329200-o5hxpl8f 15 31 RNA RNA NNP cord-329200-o5hxpl8f 15 32 genome genome NN cord-329200-o5hxpl8f 15 33 . . . cord-329200-o5hxpl8f 16 1 The the DT cord-329200-o5hxpl8f 16 2 SARS SARS NNP cord-329200-o5hxpl8f 16 3 - - HYPH cord-329200-o5hxpl8f 16 4 CoV-2 CoV-2 NNP cord-329200-o5hxpl8f 16 5 IgG igg NN cord-329200-o5hxpl8f 16 6 assay assay NN cord-329200-o5hxpl8f 16 7 ( ( -LRB- cord-329200-o5hxpl8f 16 8 Abbott Abbott NNP cord-329200-o5hxpl8f 16 9 , , , cord-329200-o5hxpl8f 16 10 Chicago Chicago NNP cord-329200-o5hxpl8f 16 11 , , , cord-329200-o5hxpl8f 16 12 IL IL NNP cord-329200-o5hxpl8f 16 13 , , , cord-329200-o5hxpl8f 16 14 USA USA NNP cord-329200-o5hxpl8f 16 15 ) ) -RRB- cord-329200-o5hxpl8f 16 16 and and CC cord-329200-o5hxpl8f 16 17 Elecsys Elecsys NNP cord-329200-o5hxpl8f 16 18 Anti Anti NNP cord-329200-o5hxpl8f 16 19 - - NNP cord-329200-o5hxpl8f 16 20 SARS SARS NNP cord-329200-o5hxpl8f 16 21 - - HYPH cord-329200-o5hxpl8f 16 22 CoV-2 CoV-2 NNP cord-329200-o5hxpl8f 16 23 assay assay NN cord-329200-o5hxpl8f 16 24 ( ( -LRB- cord-329200-o5hxpl8f 16 25 Roche Roche NNP cord-329200-o5hxpl8f 16 26 , , , cord-329200-o5hxpl8f 16 27 Basel Basel NNP cord-329200-o5hxpl8f 16 28 , , , cord-329200-o5hxpl8f 16 29 Switzerland Switzerland NNP cord-329200-o5hxpl8f 16 30 ) ) -RRB- cord-329200-o5hxpl8f 16 31 assays assay NNS cord-329200-o5hxpl8f 16 32 detect detect VBP cord-329200-o5hxpl8f 16 33 antibody antibody NN cord-329200-o5hxpl8f 16 34 to to IN cord-329200-o5hxpl8f 16 35 the the DT cord-329200-o5hxpl8f 16 36 nucleoprotein nucleoprotein NNP cord-329200-o5hxpl8f 16 37 , , , cord-329200-o5hxpl8f 16 38 whereas whereas IN cord-329200-o5hxpl8f 16 39 the the DT cord-329200-o5hxpl8f 16 40 LIAISON LIAISON NNP cord-329200-o5hxpl8f 16 41 SARS SARS NNP cord-329200-o5hxpl8f 16 42 - - HYPH cord-329200-o5hxpl8f 16 43 CoV-2 CoV-2 NNP cord-329200-o5hxpl8f 16 44 S1 S1 NNP cord-329200-o5hxpl8f 16 45 / / SYM cord-329200-o5hxpl8f 16 46 S2 S2 NNP cord-329200-o5hxpl8f 16 47 IgG IgG NNP cord-329200-o5hxpl8f 16 48 assay assay NN cord-329200-o5hxpl8f 16 49 ( ( -LRB- cord-329200-o5hxpl8f 16 50 DiaSorin DiaSorin NNP cord-329200-o5hxpl8f 16 51 , , , cord-329200-o5hxpl8f 16 52 Saluggia Saluggia NNP cord-329200-o5hxpl8f 16 53 , , , cord-329200-o5hxpl8f 16 54 Italy Italy NNP cord-329200-o5hxpl8f 16 55 ) ) -RRB- cord-329200-o5hxpl8f 16 56 , , , cord-329200-o5hxpl8f 16 57 and and CC cord-329200-o5hxpl8f 16 58 SARS SARS NNP cord-329200-o5hxpl8f 16 59 - - HYPH cord-329200-o5hxpl8f 16 60 CoV-2 CoV-2 NNP cord-329200-o5hxpl8f 16 61 Total total JJ cord-329200-o5hxpl8f 16 62 assay assay NN cord-329200-o5hxpl8f 16 63 ( ( -LRB- cord-329200-o5hxpl8f 16 64 Siemens Siemens NNP cord-329200-o5hxpl8f 16 65 , , , cord-329200-o5hxpl8f 16 66 Munich Munich NNP cord-329200-o5hxpl8f 16 67 , , , cord-329200-o5hxpl8f 16 68 Germany Germany NNP cord-329200-o5hxpl8f 16 69 ) ) -RRB- cord-329200-o5hxpl8f 16 70 detect detect VBP cord-329200-o5hxpl8f 16 71 antibodies antibody NNS cord-329200-o5hxpl8f 16 72 to to IN cord-329200-o5hxpl8f 16 73 the the DT cord-329200-o5hxpl8f 16 74 spike spike NN cord-329200-o5hxpl8f 16 75 glycoprotein glycoprotein NN cord-329200-o5hxpl8f 16 76 . . . cord-329200-o5hxpl8f 17 1 The the DT cord-329200-o5hxpl8f 17 2 Abbott Abbott NNP cord-329200-o5hxpl8f 17 3 and and CC cord-329200-o5hxpl8f 17 4 Diasorin Diasorin NNP cord-329200-o5hxpl8f 17 5 assays assay NNS cord-329200-o5hxpl8f 17 6 detect detect VBP cord-329200-o5hxpl8f 17 7 IgG igg NN cord-329200-o5hxpl8f 17 8 only only RB cord-329200-o5hxpl8f 17 9 , , , cord-329200-o5hxpl8f 17 10 whereas whereas IN cord-329200-o5hxpl8f 17 11 Roche Roche NNP cord-329200-o5hxpl8f 17 12 and and CC cord-329200-o5hxpl8f 17 13 Siemens Siemens NNP cord-329200-o5hxpl8f 17 14 detect detect VBP cord-329200-o5hxpl8f 17 15 total total JJ cord-329200-o5hxpl8f 17 16 antibody antibody NN cord-329200-o5hxpl8f 17 17 . . . cord-329200-o5hxpl8f 18 1 The the DT cord-329200-o5hxpl8f 18 2 diverse diverse JJ cord-329200-o5hxpl8f 18 3 approaches approach NNS cord-329200-o5hxpl8f 18 4 taken take VBN cord-329200-o5hxpl8f 18 5 by by IN cord-329200-o5hxpl8f 18 6 the the DT cord-329200-o5hxpl8f 18 7 four four CD cord-329200-o5hxpl8f 18 8 commercial commercial JJ cord-329200-o5hxpl8f 18 9 assays assay NNS cord-329200-o5hxpl8f 18 10 highlight highlight VBP cord-329200-o5hxpl8f 18 11 the the DT cord-329200-o5hxpl8f 18 12 challenge challenge NN cord-329200-o5hxpl8f 18 13 of of IN cord-329200-o5hxpl8f 18 14 choice choice NN cord-329200-o5hxpl8f 18 15 posed pose VBN cord-329200-o5hxpl8f 18 16 to to IN cord-329200-o5hxpl8f 18 17 laboratories laboratory NNS cord-329200-o5hxpl8f 18 18 : : : cord-329200-o5hxpl8f 18 19 all all DT cord-329200-o5hxpl8f 18 20 manufacturers manufacturer NNS cord-329200-o5hxpl8f 18 21 report report VBP cord-329200-o5hxpl8f 18 22 similarly similarly RB cord-329200-o5hxpl8f 18 23 high high JJ cord-329200-o5hxpl8f 18 24 sensitivity sensitivity NN cord-329200-o5hxpl8f 18 25 and and CC cord-329200-o5hxpl8f 18 26 specificity specificity NN cord-329200-o5hxpl8f 18 27 . . . cord-329200-o5hxpl8f 19 1 The the DT cord-329200-o5hxpl8f 19 2 authors author NNS cord-329200-o5hxpl8f 19 3 compared compare VBD cord-329200-o5hxpl8f 19 4 these these DT cord-329200-o5hxpl8f 19 5 four four CD cord-329200-o5hxpl8f 19 6 assays assay NNS cord-329200-o5hxpl8f 19 7 and and CC cord-329200-o5hxpl8f 19 8 a a DT cord-329200-o5hxpl8f 19 9 novel novel JJ cord-329200-o5hxpl8f 19 10 384-well 384-well CD cord-329200-o5hxpl8f 19 11 ELISA ELISA NNP cord-329200-o5hxpl8f 19 12 detecting detect VBG cord-329200-o5hxpl8f 19 13 total total JJ cord-329200-o5hxpl8f 19 14 IgG igg NN cord-329200-o5hxpl8f 19 15 to to IN cord-329200-o5hxpl8f 19 16 a a DT cord-329200-o5hxpl8f 19 17 trimeric trimeric JJ cord-329200-o5hxpl8f 19 18 spike spike NN cord-329200-o5hxpl8f 19 19 protein protein NN cord-329200-o5hxpl8f 19 20 and and CC cord-329200-o5hxpl8f 19 21 used use VBD cord-329200-o5hxpl8f 19 22 all all DT cord-329200-o5hxpl8f 19 23 five five CD cord-329200-o5hxpl8f 19 24 assays assay NNS cord-329200-o5hxpl8f 19 25 on on IN cord-329200-o5hxpl8f 19 26 976 976 CD cord-329200-o5hxpl8f 19 27 pre pre JJ cord-329200-o5hxpl8f 19 28 - - JJ cord-329200-o5hxpl8f 19 29 pandemic pandemic JJ cord-329200-o5hxpl8f 19 30 samples sample NNS cord-329200-o5hxpl8f 19 31 presumed presume VBN cord-329200-o5hxpl8f 19 32 to to TO cord-329200-o5hxpl8f 19 33 be be VB cord-329200-o5hxpl8f 19 34 negative negative JJ cord-329200-o5hxpl8f 19 35 , , , cord-329200-o5hxpl8f 19 36 collected collect VBN cord-329200-o5hxpl8f 19 37 between between IN cord-329200-o5hxpl8f 19 38 2014 2014 CD cord-329200-o5hxpl8f 19 39 and and CC cord-329200-o5hxpl8f 19 40 2016 2016 CD cord-329200-o5hxpl8f 19 41 , , , cord-329200-o5hxpl8f 19 42 and and CC cord-329200-o5hxpl8f 19 43 536 536 CD cord-329200-o5hxpl8f 19 44 serum serum NN cord-329200-o5hxpl8f 19 45 samples sample NNS cord-329200-o5hxpl8f 19 46 from from IN cord-329200-o5hxpl8f 19 47 patients patient NNS cord-329200-o5hxpl8f 19 48 with with IN cord-329200-o5hxpl8f 19 49 laboratory laboratory NN cord-329200-o5hxpl8f 19 50 - - HYPH cord-329200-o5hxpl8f 19 51 confirmed confirm VBN cord-329200-o5hxpl8f 19 52 COVID-19 COVID-19 NNP cord-329200-o5hxpl8f 19 53 from from IN cord-329200-o5hxpl8f 19 54 research research NN cord-329200-o5hxpl8f 19 55 studies study NNS cord-329200-o5hxpl8f 19 56 in in IN cord-329200-o5hxpl8f 19 57 Oxford Oxford NNP cord-329200-o5hxpl8f 19 58 , , , cord-329200-o5hxpl8f 19 59 UK UK NNP cord-329200-o5hxpl8f 19 60 , , , cord-329200-o5hxpl8f 19 61 or or CC cord-329200-o5hxpl8f 19 62 plasma plasma NN cord-329200-o5hxpl8f 19 63 donors donor NNS cord-329200-o5hxpl8f 19 64 . . . cord-329200-o5hxpl8f 20 1 The the DT cord-329200-o5hxpl8f 20 2 authors author NNS cord-329200-o5hxpl8f 20 3 report report VBP cord-329200-o5hxpl8f 20 4 that that IN cord-329200-o5hxpl8f 20 5 all all DT cord-329200-o5hxpl8f 20 6 assays assay NNS cord-329200-o5hxpl8f 20 7 had have VBD cord-329200-o5hxpl8f 20 8 a a DT cord-329200-o5hxpl8f 20 9 high high JJ cord-329200-o5hxpl8f 20 10 sensitivity sensitivity NN cord-329200-o5hxpl8f 20 11 ( ( -LRB- cord-329200-o5hxpl8f 20 12 92·7 92·7 CD cord-329200-o5hxpl8f 20 13 - - HYPH cord-329200-o5hxpl8f 20 14 99·1 99·1 CD cord-329200-o5hxpl8f 20 15 % % NN cord-329200-o5hxpl8f 20 16 ) ) -RRB- cord-329200-o5hxpl8f 20 17 and and CC cord-329200-o5hxpl8f 20 18 specificity specificity NN cord-329200-o5hxpl8f 20 19 ( ( -LRB- cord-329200-o5hxpl8f 20 20 98·7 98·7 NNP cord-329200-o5hxpl8f 20 21 - - HYPH cord-329200-o5hxpl8f 20 22 99·9 99·9 CD cord-329200-o5hxpl8f 20 23 % % NN cord-329200-o5hxpl8f 20 24 ) ) -RRB- cord-329200-o5hxpl8f 20 25 . . . cord-329200-o5hxpl8f 21 1 The the DT cord-329200-o5hxpl8f 21 2 most most RBS cord-329200-o5hxpl8f 21 3 sensitive sensitive JJ cord-329200-o5hxpl8f 21 4 test test NN cord-329200-o5hxpl8f 21 5 assessed assess VBN cord-329200-o5hxpl8f 21 6 was be VBD cord-329200-o5hxpl8f 21 7 the the DT cord-329200-o5hxpl8f 21 8 in in IN cord-329200-o5hxpl8f 21 9 - - HYPH cord-329200-o5hxpl8f 21 10 house house NN cord-329200-o5hxpl8f 21 11 ELISA ELISA NNP cord-329200-o5hxpl8f 21 12 . . . cord-329200-o5hxpl8f 22 1 The the DT cord-329200-o5hxpl8f 22 2 Abbott Abbott NNP cord-329200-o5hxpl8f 22 3 , , , cord-329200-o5hxpl8f 22 4 Roche Roche NNP cord-329200-o5hxpl8f 22 5 , , , cord-329200-o5hxpl8f 22 6 and and CC cord-329200-o5hxpl8f 22 7 Siemens Siemens NNP cord-329200-o5hxpl8f 22 8 assays assay NNS cord-329200-o5hxpl8f 22 9 were be VBD cord-329200-o5hxpl8f 22 10 the the DT cord-329200-o5hxpl8f 22 11 most most RBS cord-329200-o5hxpl8f 22 12 specific specific JJ cord-329200-o5hxpl8f 22 13 . . . cord-329200-o5hxpl8f 23 1 The the DT cord-329200-o5hxpl8f 23 2 benefit benefit NN cord-329200-o5hxpl8f 23 3 of of IN cord-329200-o5hxpl8f 23 4 the the DT cord-329200-o5hxpl8f 23 5 huge huge JJ cord-329200-o5hxpl8f 23 6 sample sample NN cord-329200-o5hxpl8f 23 7 bank bank NN cord-329200-o5hxpl8f 23 8 available available JJ cord-329200-o5hxpl8f 23 9 to to IN cord-329200-o5hxpl8f 23 10 these these DT cord-329200-o5hxpl8f 23 11 authors author NNS cord-329200-o5hxpl8f 23 12 was be VBD cord-329200-o5hxpl8f 23 13 the the DT cord-329200-o5hxpl8f 23 14 clearly clearly RB cord-329200-o5hxpl8f 23 15 documented document VBN cord-329200-o5hxpl8f 23 16 time time NN cord-329200-o5hxpl8f 23 17 since since IN cord-329200-o5hxpl8f 23 18 PCR PCR NNP cord-329200-o5hxpl8f 23 19 positivity positivity NN cord-329200-o5hxpl8f 23 20 , , , cord-329200-o5hxpl8f 23 21 which which WDT cord-329200-o5hxpl8f 23 22 allowed allow VBD cord-329200-o5hxpl8f 23 23 them -PRON- PRP cord-329200-o5hxpl8f 23 24 to to TO cord-329200-o5hxpl8f 23 25 optimise optimise VB cord-329200-o5hxpl8f 23 26 the the DT cord-329200-o5hxpl8f 23 27 manufacturers manufacturer NNS cord-329200-o5hxpl8f 23 28 ' ' POS cord-329200-o5hxpl8f 23 29 cut cut VBN cord-329200-o5hxpl8f 23 30 offs off NNS cord-329200-o5hxpl8f 23 31 and and CC cord-329200-o5hxpl8f 23 32 improve improve VB cord-329200-o5hxpl8f 23 33 sensitivity sensitivity NN cord-329200-o5hxpl8f 23 34 . . . cord-329200-o5hxpl8f 24 1 Only only RB cord-329200-o5hxpl8f 24 2 three three CD cord-329200-o5hxpl8f 24 3 cases case NNS cord-329200-o5hxpl8f 24 4 did do VBD cord-329200-o5hxpl8f 24 5 not not RB cord-329200-o5hxpl8f 24 6 give give VB cord-329200-o5hxpl8f 24 7 rise rise NN cord-329200-o5hxpl8f 24 8 to to IN cord-329200-o5hxpl8f 24 9 any any DT cord-329200-o5hxpl8f 24 10 detectable detectable JJ cord-329200-o5hxpl8f 24 11 antibody antibody NN cord-329200-o5hxpl8f 24 12 responses response NNS cord-329200-o5hxpl8f 24 13 in in IN cord-329200-o5hxpl8f 24 14 all all DT cord-329200-o5hxpl8f 24 15 five five CD cord-329200-o5hxpl8f 24 16 of of IN cord-329200-o5hxpl8f 24 17 the the DT cord-329200-o5hxpl8f 24 18 assays assay NNS cord-329200-o5hxpl8f 24 19 , , , cord-329200-o5hxpl8f 24 20 possibly possibly RB cord-329200-o5hxpl8f 24 21 because because IN cord-329200-o5hxpl8f 24 22 of of IN cord-329200-o5hxpl8f 24 23 a a DT cord-329200-o5hxpl8f 24 24 genuine genuine JJ cord-329200-o5hxpl8f 24 25 lack lack NN cord-329200-o5hxpl8f 24 26 of of IN cord-329200-o5hxpl8f 24 27 response response NN cord-329200-o5hxpl8f 24 28 in in IN cord-329200-o5hxpl8f 24 29 infected infected JJ cord-329200-o5hxpl8f 24 30 individuals individual NNS cord-329200-o5hxpl8f 24 31 , , , cord-329200-o5hxpl8f 24 32 or or CC cord-329200-o5hxpl8f 24 33 a a DT cord-329200-o5hxpl8f 24 34 false false JJ cord-329200-o5hxpl8f 24 35 - - HYPH cord-329200-o5hxpl8f 24 36 positive positive JJ cord-329200-o5hxpl8f 24 37 quantitative quantitative JJ cord-329200-o5hxpl8f 24 38 PCR pcr NN cord-329200-o5hxpl8f 24 39 result result NN cord-329200-o5hxpl8f 24 40 . . . cord-329200-o5hxpl8f 25 1 A a DT cord-329200-o5hxpl8f 25 2 limitation limitation NN cord-329200-o5hxpl8f 25 3 of of IN cord-329200-o5hxpl8f 25 4 this this DT cord-329200-o5hxpl8f 25 5 work work NN cord-329200-o5hxpl8f 25 6 is be VBZ cord-329200-o5hxpl8f 25 7 the the DT cord-329200-o5hxpl8f 25 8 small small JJ cord-329200-o5hxpl8f 25 9 number number NN cord-329200-o5hxpl8f 25 10 of of IN cord-329200-o5hxpl8f 25 11 pauci pauci NN cord-329200-o5hxpl8f 25 12 - - HYPH cord-329200-o5hxpl8f 25 13 symptomatic symptomatic JJ cord-329200-o5hxpl8f 25 14 and and CC cord-329200-o5hxpl8f 25 15 asymptomatic asymptomatic JJ cord-329200-o5hxpl8f 25 16 cases case NNS cord-329200-o5hxpl8f 25 17 analysed analyse VBN cord-329200-o5hxpl8f 25 18 . . . cord-329200-o5hxpl8f 26 1 Antibody antibody NN cord-329200-o5hxpl8f 26 2 responses response NNS cord-329200-o5hxpl8f 26 3 in in IN cord-329200-o5hxpl8f 26 4 these these DT cord-329200-o5hxpl8f 26 5 individuals individual NNS cord-329200-o5hxpl8f 26 6 are be VBP cord-329200-o5hxpl8f 26 7 likely likely JJ cord-329200-o5hxpl8f 26 8 to to TO cord-329200-o5hxpl8f 26 9 be be VB cord-329200-o5hxpl8f 26 10 lower low JJR cord-329200-o5hxpl8f 26 11 , , , cord-329200-o5hxpl8f 26 12 and and CC cord-329200-o5hxpl8f 26 13 therefore therefore RB cord-329200-o5hxpl8f 26 14 the the DT cord-329200-o5hxpl8f 26 15 sensitivity sensitivity NN cord-329200-o5hxpl8f 26 16 of of IN cord-329200-o5hxpl8f 26 17 all all DT cord-329200-o5hxpl8f 26 18 assays assay NNS cord-329200-o5hxpl8f 26 19 might may MD cord-329200-o5hxpl8f 26 20 be be VB cord-329200-o5hxpl8f 26 21 somewhat somewhat RB cord-329200-o5hxpl8f 26 22 less less JJR cord-329200-o5hxpl8f 26 23 than than IN cord-329200-o5hxpl8f 26 24 that that DT cord-329200-o5hxpl8f 26 25 reported report VBN cord-329200-o5hxpl8f 26 26 . . . cord-329200-o5hxpl8f 27 1 Also also RB cord-329200-o5hxpl8f 27 2 , , , cord-329200-o5hxpl8f 27 3 data datum NNS cord-329200-o5hxpl8f 27 4 on on IN cord-329200-o5hxpl8f 27 5 sex sex NN cord-329200-o5hxpl8f 27 6 , , , cord-329200-o5hxpl8f 27 7 age age NN cord-329200-o5hxpl8f 27 8 , , , cord-329200-o5hxpl8f 27 9 and and CC cord-329200-o5hxpl8f 27 10 immunocompromise immunocompromise JJ cord-329200-o5hxpl8f 27 11 status status NN cord-329200-o5hxpl8f 27 12 were be VBD cord-329200-o5hxpl8f 27 13 incomplete incomplete JJ cord-329200-o5hxpl8f 27 14 , , , cord-329200-o5hxpl8f 27 15 meaning mean VBG cord-329200-o5hxpl8f 27 16 that that IN cord-329200-o5hxpl8f 27 17 the the DT cord-329200-o5hxpl8f 27 18 results result NNS cord-329200-o5hxpl8f 27 19 could could MD cord-329200-o5hxpl8f 27 20 be be VB cord-329200-o5hxpl8f 27 21 limited limit VBN cord-329200-o5hxpl8f 27 22 in in IN cord-329200-o5hxpl8f 27 23 their -PRON- PRP$ cord-329200-o5hxpl8f 27 24 application application NN cord-329200-o5hxpl8f 27 25 to to IN cord-329200-o5hxpl8f 27 26 specific specific JJ cord-329200-o5hxpl8f 27 27 patient patient JJ cord-329200-o5hxpl8f 27 28 groups group NNS cord-329200-o5hxpl8f 27 29 . . . cord-329200-o5hxpl8f 28 1 This this DT cord-329200-o5hxpl8f 28 2 limitation limitation NN cord-329200-o5hxpl8f 28 3 could could MD cord-329200-o5hxpl8f 28 4 be be VB cord-329200-o5hxpl8f 28 5 especially especially RB cord-329200-o5hxpl8f 28 6 important important JJ cord-329200-o5hxpl8f 28 7 in in IN cord-329200-o5hxpl8f 28 8 children child NNS cord-329200-o5hxpl8f 28 9 , , , cord-329200-o5hxpl8f 28 10 who who WP cord-329200-o5hxpl8f 28 11 are be VBP cord-329200-o5hxpl8f 28 12 more more RBR cord-329200-o5hxpl8f 28 13 likely likely JJ cord-329200-o5hxpl8f 28 14 than than IN cord-329200-o5hxpl8f 28 15 adults adult NNS cord-329200-o5hxpl8f 28 16 are be VBP cord-329200-o5hxpl8f 28 17 to to TO cord-329200-o5hxpl8f 28 18 have have VB cord-329200-o5hxpl8f 28 19 had have VBN cord-329200-o5hxpl8f 28 20 a a DT cord-329200-o5hxpl8f 28 21 recent recent JJ cord-329200-o5hxpl8f 28 22 infection infection NN cord-329200-o5hxpl8f 28 23 with with IN cord-329200-o5hxpl8f 28 24 a a DT cord-329200-o5hxpl8f 28 25 seasonal seasonal JJ cord-329200-o5hxpl8f 28 26 coronavirus coronavirus NN cord-329200-o5hxpl8f 28 27 . . . cord-329200-o5hxpl8f 29 1 The the DT cord-329200-o5hxpl8f 29 2 expectation expectation NN cord-329200-o5hxpl8f 29 3 is be VBZ cord-329200-o5hxpl8f 29 4 that that IN cord-329200-o5hxpl8f 29 5 the the DT cord-329200-o5hxpl8f 29 6 best good JJS cord-329200-o5hxpl8f 29 7 predictor predictor NN cord-329200-o5hxpl8f 29 8 of of IN cord-329200-o5hxpl8f 29 9 antibodymediated antibodymediated JJ cord-329200-o5hxpl8f 29 10 protection protection NN cord-329200-o5hxpl8f 29 11 will will MD cord-329200-o5hxpl8f 29 12 come come VB cord-329200-o5hxpl8f 29 13 from from IN cord-329200-o5hxpl8f 29 14 neutralisation neutralisation NN cord-329200-o5hxpl8f 29 15 assays assay NNS cord-329200-o5hxpl8f 29 16 , , , cord-329200-o5hxpl8f 29 17 in in IN cord-329200-o5hxpl8f 29 18 which which WDT cord-329200-o5hxpl8f 29 19 the the DT cord-329200-o5hxpl8f 29 20 ability ability NN cord-329200-o5hxpl8f 29 21 of of IN cord-329200-o5hxpl8f 29 22 patient patient JJ cord-329200-o5hxpl8f 29 23 serum serum NN cord-329200-o5hxpl8f 29 24 to to TO cord-329200-o5hxpl8f 29 25 prevent prevent VB cord-329200-o5hxpl8f 29 26 live live JJ cord-329200-o5hxpl8f 29 27 virus virus NN cord-329200-o5hxpl8f 29 28 infecting infect VBG cord-329200-o5hxpl8f 29 29 cell cell NN cord-329200-o5hxpl8f 29 30 cultures culture NNS cord-329200-o5hxpl8f 29 31 is be VBZ cord-329200-o5hxpl8f 29 32 measured measure VBN cord-329200-o5hxpl8f 29 33 . . . cord-329200-o5hxpl8f 30 1 These these DT cord-329200-o5hxpl8f 30 2 assays assay NNS cord-329200-o5hxpl8f 30 3 are be VBP cord-329200-o5hxpl8f 30 4 impractical impractical JJ cord-329200-o5hxpl8f 30 5 to to TO cord-329200-o5hxpl8f 30 6 deploy deploy VB cord-329200-o5hxpl8f 30 7 at at IN cord-329200-o5hxpl8f 30 8 scale scale NN cord-329200-o5hxpl8f 30 9 . . . cord-329200-o5hxpl8f 31 1 The the DT cord-329200-o5hxpl8f 31 2 presence presence NN cord-329200-o5hxpl8f 31 3 of of IN cord-329200-o5hxpl8f 31 4 antibodies antibody NNS cord-329200-o5hxpl8f 31 5 against against IN cord-329200-o5hxpl8f 31 6 the the DT cord-329200-o5hxpl8f 31 7 spike spike NN cord-329200-o5hxpl8f 31 8 protein protein NN cord-329200-o5hxpl8f 31 9 of of IN cord-329200-o5hxpl8f 31 10 SARS SARS NNP cord-329200-o5hxpl8f 31 11 - - HYPH cord-329200-o5hxpl8f 31 12 CoV-2 CoV-2 NNP cord-329200-o5hxpl8f 31 13 correlates correlate VBZ cord-329200-o5hxpl8f 31 14 well well RB cord-329200-o5hxpl8f 31 15 with with IN cord-329200-o5hxpl8f 31 16 neutralisation neutralisation NN cord-329200-o5hxpl8f 31 17 . . . cord-329200-o5hxpl8f 32 1 2,3 2,3 LS cord-329200-o5hxpl8f 33 1 The the DT cord-329200-o5hxpl8f 33 2 DiaSorin DiaSorin NNPS cord-329200-o5hxpl8f 33 3 , , , cord-329200-o5hxpl8f 33 4 Siemens Siemens NNP cord-329200-o5hxpl8f 33 5 , , , cord-329200-o5hxpl8f 33 6 and and CC cord-329200-o5hxpl8f 33 7 in in IN cord-329200-o5hxpl8f 33 8 - - HYPH cord-329200-o5hxpl8f 33 9 house house NN cord-329200-o5hxpl8f 33 10 assays assay NNS cord-329200-o5hxpl8f 33 11 measured measure VBD cord-329200-o5hxpl8f 33 12 these these DT cord-329200-o5hxpl8f 33 13 potentially potentially RB cord-329200-o5hxpl8f 33 14 protective protective JJ cord-329200-o5hxpl8f 33 15 antibodies antibody NNS cord-329200-o5hxpl8f 33 16 , , , cord-329200-o5hxpl8f 33 17 with with IN cord-329200-o5hxpl8f 33 18 the the DT cord-329200-o5hxpl8f 33 19 inhouse inhouse NN cord-329200-o5hxpl8f 33 20 ELISA ELISA NNP cord-329200-o5hxpl8f 33 21 using use VBG cord-329200-o5hxpl8f 33 22 trimerised trimerised JJ cord-329200-o5hxpl8f 33 23 spike spike NN cord-329200-o5hxpl8f 33 24 protein protein NN cord-329200-o5hxpl8f 33 25 , , , cord-329200-o5hxpl8f 33 26 which which WDT cord-329200-o5hxpl8f 33 27 shows show VBZ cord-329200-o5hxpl8f 33 28 a a DT cord-329200-o5hxpl8f 33 29 high high JJ cord-329200-o5hxpl8f 33 30 correlation correlation NN cord-329200-o5hxpl8f 33 31 with with IN cord-329200-o5hxpl8f 33 32 neutralisation neutralisation NN cord-329200-o5hxpl8f 33 33 . . . cord-329200-o5hxpl8f 34 1 4 4 LS cord-329200-o5hxpl8f 34 2 , , , cord-329200-o5hxpl8f 34 3 5 5 CD cord-329200-o5hxpl8f 34 4 , , , cord-329200-o5hxpl8f 34 5 6 6 CD cord-329200-o5hxpl8f 35 1 Further further JJ cord-329200-o5hxpl8f 35 2 work work NN cord-329200-o5hxpl8f 35 3 is be VBZ cord-329200-o5hxpl8f 35 4 required require VBN cord-329200-o5hxpl8f 35 5 to to TO cord-329200-o5hxpl8f 35 6 investigate investigate VB cord-329200-o5hxpl8f 35 7 what what WP cord-329200-o5hxpl8f 35 8 titre titre NN cord-329200-o5hxpl8f 35 9 of of IN cord-329200-o5hxpl8f 35 10 neutralising neutralise VBG cord-329200-o5hxpl8f 35 11 antibodies antibody NNS cord-329200-o5hxpl8f 35 12 correlates correlate VBZ cord-329200-o5hxpl8f 35 13 with with IN cord-329200-o5hxpl8f 35 14 protection protection NN cord-329200-o5hxpl8f 35 15 , , , cord-329200-o5hxpl8f 35 16 how how WRB cord-329200-o5hxpl8f 35 17 long long JJ cord-329200-o5hxpl8f 35 18 neutralisation neutralisation NN cord-329200-o5hxpl8f 35 19 activity activity NN cord-329200-o5hxpl8f 35 20 persists persist VBZ cord-329200-o5hxpl8f 35 21 , , , cord-329200-o5hxpl8f 35 22 and and CC cord-329200-o5hxpl8f 35 23 which which WDT cord-329200-o5hxpl8f 35 24 assay assay NN cord-329200-o5hxpl8f 35 25 best best RB cord-329200-o5hxpl8f 35 26 predicts predict VBZ cord-329200-o5hxpl8f 35 27 that that DT cord-329200-o5hxpl8f 35 28 . . . cord-329200-o5hxpl8f 36 1 Identifying identify VBG cord-329200-o5hxpl8f 36 2 an an DT cord-329200-o5hxpl8f 36 3 appropriate appropriate JJ cord-329200-o5hxpl8f 36 4 assay assay NN cord-329200-o5hxpl8f 36 5 will will MD cord-329200-o5hxpl8f 36 6 be be VB cord-329200-o5hxpl8f 36 7 crucial crucial JJ cord-329200-o5hxpl8f 36 8 for for IN cord-329200-o5hxpl8f 36 9 assessing assess VBG cord-329200-o5hxpl8f 36 10 vaccine vaccine NN cord-329200-o5hxpl8f 36 11 responses response NNS cord-329200-o5hxpl8f 36 12 , , , cord-329200-o5hxpl8f 36 13 and and CC cord-329200-o5hxpl8f 36 14 for for IN cord-329200-o5hxpl8f 36 15 assessing assess VBG cord-329200-o5hxpl8f 36 16 potential potential JJ cord-329200-o5hxpl8f 36 17 risk risk NN cord-329200-o5hxpl8f 36 18 of of IN cord-329200-o5hxpl8f 36 19 reinfection reinfection NN cord-329200-o5hxpl8f 36 20 , , , cord-329200-o5hxpl8f 36 21 which which WDT cord-329200-o5hxpl8f 36 22 has have VBZ cord-329200-o5hxpl8f 36 23 been be VBN cord-329200-o5hxpl8f 36 24 shown show VBN cord-329200-o5hxpl8f 36 25 with with IN cord-329200-o5hxpl8f 36 26 seasonal seasonal JJ cord-329200-o5hxpl8f 36 27 coronaviruses coronaviruse NNS cord-329200-o5hxpl8f 36 28 , , , cord-329200-o5hxpl8f 36 29 7 7 CD cord-329200-o5hxpl8f 36 30 but but CC cord-329200-o5hxpl8f 36 31 not not RB cord-329200-o5hxpl8f 36 32 so so RB cord-329200-o5hxpl8f 36 33 far far RB cord-329200-o5hxpl8f 36 34 for for IN cord-329200-o5hxpl8f 36 35 SARS SARS NNP cord-329200-o5hxpl8f 36 36 - - HYPH cord-329200-o5hxpl8f 36 37 CoV-2 CoV-2 NNP cord-329200-o5hxpl8f 36 38 . . . cord-329200-o5hxpl8f 37 1 Consistent consistent JJ cord-329200-o5hxpl8f 37 2 with with IN cord-329200-o5hxpl8f 37 3 this this DT cord-329200-o5hxpl8f 37 4 future future JJ cord-329200-o5hxpl8f 37 5 possibility possibility NN cord-329200-o5hxpl8f 37 6 , , , cord-329200-o5hxpl8f 37 7 the the DT cord-329200-o5hxpl8f 37 8 neutralisation neutralisation NN cord-329200-o5hxpl8f 37 9 potency potency NN cord-329200-o5hxpl8f 37 10 of of IN cord-329200-o5hxpl8f 37 11 serum serum NN cord-329200-o5hxpl8f 37 12 declines decline NNS cord-329200-o5hxpl8f 37 13 in in IN cord-329200-o5hxpl8f 37 14 the the DT cord-329200-o5hxpl8f 37 15 months month NNS cord-329200-o5hxpl8f 37 16 post post NN cord-329200-o5hxpl8f 37 17 infection infection NN cord-329200-o5hxpl8f 37 18 . . . cord-329200-o5hxpl8f 38 1 8 8 CD cord-329200-o5hxpl8f 38 2 , , , cord-329200-o5hxpl8f 38 3 9 9 CD cord-329200-o5hxpl8f 39 1 As as IN cord-329200-o5hxpl8f 39 2 our -PRON- PRP$ cord-329200-o5hxpl8f 39 3 understanding understanding NN cord-329200-o5hxpl8f 39 4 of of IN cord-329200-o5hxpl8f 39 5 immunity immunity NN cord-329200-o5hxpl8f 39 6 and and CC cord-329200-o5hxpl8f 39 7 the the DT cord-329200-o5hxpl8f 39 8 correlates correlate NNS cord-329200-o5hxpl8f 39 9 of of IN cord-329200-o5hxpl8f 39 10 protection protection NN cord-329200-o5hxpl8f 39 11 ( ( -LRB- cord-329200-o5hxpl8f 39 12 both both DT cord-329200-o5hxpl8f 39 13 cellular cellular JJ cord-329200-o5hxpl8f 39 14 and and CC cord-329200-o5hxpl8f 39 15 humoral humoral JJ cord-329200-o5hxpl8f 39 16 ) ) -RRB- cord-329200-o5hxpl8f 39 17 increases increase NNS cord-329200-o5hxpl8f 39 18 and and CC cord-329200-o5hxpl8f 39 19 the the DT cord-329200-o5hxpl8f 39 20 range range NN cord-329200-o5hxpl8f 39 21 of of IN cord-329200-o5hxpl8f 39 22 immunoassays immunoassays NNP cord-329200-o5hxpl8f 39 23 multiplies multiply VBZ cord-329200-o5hxpl8f 39 24 , , , cord-329200-o5hxpl8f 40 1 we -PRON- PRP cord-329200-o5hxpl8f 40 2 will will MD cord-329200-o5hxpl8f 40 3 probably probably RB cord-329200-o5hxpl8f 40 4 Flickr Flickr NNP cord-329200-o5hxpl8f 40 5 -NIAID -NIAID . cord-329200-o5hxpl8f 41 1 use use VB cord-329200-o5hxpl8f 41 2 different different JJ cord-329200-o5hxpl8f 41 3 assays assay NNS cord-329200-o5hxpl8f 41 4 to to TO cord-329200-o5hxpl8f 41 5 answer answer VB cord-329200-o5hxpl8f 41 6 specific specific JJ cord-329200-o5hxpl8f 41 7 questions question NNS cord-329200-o5hxpl8f 41 8 . . . cord-329200-o5hxpl8f 42 1 For for IN cord-329200-o5hxpl8f 42 2 example example NN cord-329200-o5hxpl8f 42 3 , , , cord-329200-o5hxpl8f 42 4 most most JJS cord-329200-o5hxpl8f 42 5 vaccine vaccine NN cord-329200-o5hxpl8f 42 6 candidates candidate NNS cord-329200-o5hxpl8f 42 7 elicit elicit VBP cord-329200-o5hxpl8f 42 8 responses response NNS cord-329200-o5hxpl8f 42 9 to to TO cord-329200-o5hxpl8f 42 10 spike spike VB cord-329200-o5hxpl8f 42 11 rather rather RB cord-329200-o5hxpl8f 42 12 than than IN cord-329200-o5hxpl8f 42 13 nucleocapsid nucleocapsid NNP cord-329200-o5hxpl8f 42 14 protein protein NNP cord-329200-o5hxpl8f 42 15 . . . cord-329200-o5hxpl8f 43 1 Measuring measure VBG cord-329200-o5hxpl8f 43 2 antibodies antibody NNS cord-329200-o5hxpl8f 43 3 to to TO cord-329200-o5hxpl8f 43 4 spike spike VB cord-329200-o5hxpl8f 43 5 will will MD cord-329200-o5hxpl8f 43 6 therefore therefore RB cord-329200-o5hxpl8f 43 7 indicate indicate VB cord-329200-o5hxpl8f 43 8 whether whether IN cord-329200-o5hxpl8f 43 9 there there EX cord-329200-o5hxpl8f 43 10 has have VBZ cord-329200-o5hxpl8f 43 11 been be VBN cord-329200-o5hxpl8f 43 12 a a DT cord-329200-o5hxpl8f 43 13 good good JJ cord-329200-o5hxpl8f 43 14 response response NN cord-329200-o5hxpl8f 43 15 , , , cord-329200-o5hxpl8f 43 16 whereas whereas IN cord-329200-o5hxpl8f 43 17 measuring measure VBG cord-329200-o5hxpl8f 43 18 antibodies antibody NNS cord-329200-o5hxpl8f 43 19 to to IN cord-329200-o5hxpl8f 43 20 nucleocapsid nucleocapsid NN cord-329200-o5hxpl8f 43 21 would would MD cord-329200-o5hxpl8f 43 22 help help VB cord-329200-o5hxpl8f 43 23 identify identify VB cord-329200-o5hxpl8f 43 24 whether whether IN cord-329200-o5hxpl8f 43 25 the the DT cord-329200-o5hxpl8f 43 26 individual individual NN cord-329200-o5hxpl8f 43 27 had have VBD cord-329200-o5hxpl8f 43 28 nonetheless nonetheless RB cord-329200-o5hxpl8f 43 29 become become VBN cord-329200-o5hxpl8f 43 30 infected infected JJ cord-329200-o5hxpl8f 43 31 . . . cord-329200-o5hxpl8f 44 1 Measuring measure VBG cord-329200-o5hxpl8f 44 2 the the DT cord-329200-o5hxpl8f 44 3 different different JJ cord-329200-o5hxpl8f 44 4 antibodies antibody NNS cord-329200-o5hxpl8f 44 5 might may MD cord-329200-o5hxpl8f 44 6 also also RB cord-329200-o5hxpl8f 44 7 have have VB cord-329200-o5hxpl8f 44 8 prognostic prognostic JJ cord-329200-o5hxpl8f 44 9 value value NN cord-329200-o5hxpl8f 44 10 ; ; : cord-329200-o5hxpl8f 44 11 a a DT cord-329200-o5hxpl8f 44 12 report report NN cord-329200-o5hxpl8f 44 13 showed show VBD cord-329200-o5hxpl8f 44 14 that that IN cord-329200-o5hxpl8f 44 15 a a DT cord-329200-o5hxpl8f 44 16 predominant predominant JJ cord-329200-o5hxpl8f 44 17 humoral humoral JJ cord-329200-o5hxpl8f 44 18 response response NN cord-329200-o5hxpl8f 44 19 to to IN cord-329200-o5hxpl8f 44 20 nucleoprotein nucleoprotein NNP cord-329200-o5hxpl8f 44 21 is be VBZ cord-329200-o5hxpl8f 44 22 associated associate VBN cord-329200-o5hxpl8f 44 23 with with IN cord-329200-o5hxpl8f 44 24 poor poor JJ cord-329200-o5hxpl8f 44 25 outcome outcome NN cord-329200-o5hxpl8f 44 26 in in IN cord-329200-o5hxpl8f 44 27 patients patient NNS cord-329200-o5hxpl8f 44 28 admitted admit VBN cord-329200-o5hxpl8f 44 29 to to IN cord-329200-o5hxpl8f 44 30 hospital hospital NN cord-329200-o5hxpl8f 44 31 , , , cord-329200-o5hxpl8f 44 32 compared compare VBN cord-329200-o5hxpl8f 44 33 with with IN cord-329200-o5hxpl8f 44 34 that that DT cord-329200-o5hxpl8f 44 35 of of IN cord-329200-o5hxpl8f 44 36 spike spike NN cord-329200-o5hxpl8f 44 37 . . . cord-329200-o5hxpl8f 45 1 10 10 CD cord-329200-o5hxpl8f 46 1 Further further JJ cord-329200-o5hxpl8f 46 2 investigation investigation NN cord-329200-o5hxpl8f 46 3 is be VBZ cord-329200-o5hxpl8f 46 4 required require VBN cord-329200-o5hxpl8f 46 5 and and CC cord-329200-o5hxpl8f 46 6 the the DT cord-329200-o5hxpl8f 46 7 possibility possibility NN cord-329200-o5hxpl8f 46 8 of of IN cord-329200-o5hxpl8f 46 9 a a DT cord-329200-o5hxpl8f 46 10 one one CD cord-329200-o5hxpl8f 46 11 - - HYPH cord-329200-o5hxpl8f 46 12 size size NN cord-329200-o5hxpl8f 46 13 - - HYPH cord-329200-o5hxpl8f 46 14 fits fit VBZ cord-329200-o5hxpl8f 46 15 - - HYPH cord-329200-o5hxpl8f 46 16 all all DT cord-329200-o5hxpl8f 46 17 immunological immunological JJ cord-329200-o5hxpl8f 46 18 assay assay NN cord-329200-o5hxpl8f 46 19 looks look VBZ cord-329200-o5hxpl8f 46 20 less less RBR cord-329200-o5hxpl8f 46 21 and and CC cord-329200-o5hxpl8f 46 22 less less RBR cord-329200-o5hxpl8f 46 23 likely likely JJ cord-329200-o5hxpl8f 46 24 . . . cord-329200-o5hxpl8f 47 1 We -PRON- PRP cord-329200-o5hxpl8f 47 2 declare declare VBP cord-329200-o5hxpl8f 47 3 no no DT cord-329200-o5hxpl8f 47 4 competing compete VBG cord-329200-o5hxpl8f 47 5 interests interest NNS cord-329200-o5hxpl8f 47 6 . . . cord-329200-o5hxpl8f 48 1 The the DT cord-329200-o5hxpl8f 48 2 National National NNP cord-329200-o5hxpl8f 48 3 SARS SARS NNP cord-329200-o5hxpl8f 48 4 - - HYPH cord-329200-o5hxpl8f 48 5 CoV-2 CoV-2 NNP cord-329200-o5hxpl8f 48 6 Serology Serology NNP cord-329200-o5hxpl8f 48 7 Assay Assay NNP cord-329200-o5hxpl8f 48 8 Evaluation Evaluation NNP cord-329200-o5hxpl8f 48 9 Group Group NNP cord-329200-o5hxpl8f 48 10 . . . cord-329200-o5hxpl8f 49 1 Performance performance NN cord-329200-o5hxpl8f 49 2 characteristics characteristic NNS cord-329200-o5hxpl8f 49 3 of of IN cord-329200-o5hxpl8f 49 4 five five CD cord-329200-o5hxpl8f 49 5 immunoassays immunoassay NNS cord-329200-o5hxpl8f 49 6 for for IN cord-329200-o5hxpl8f 49 7 SARS SARS NNP cord-329200-o5hxpl8f 49 8 - - HYPH cord-329200-o5hxpl8f 49 9 CoV-2 CoV-2 NNP cord-329200-o5hxpl8f 49 10 : : : cord-329200-o5hxpl8f 49 11 a a DT cord-329200-o5hxpl8f 49 12 head head NN cord-329200-o5hxpl8f 49 13 - - HYPH cord-329200-o5hxpl8f 49 14 to to IN cord-329200-o5hxpl8f 49 15 - - HYPH cord-329200-o5hxpl8f 49 16 head head NN cord-329200-o5hxpl8f 49 17 benchmark benchmark NN cord-329200-o5hxpl8f 49 18 comparison comparison NN cord-329200-o5hxpl8f 49 19 . . . cord-329200-o5hxpl8f 50 1 Lancet Lancet NNP cord-329200-o5hxpl8f 50 2 Infect infect VB cord-329200-o5hxpl8f 50 3 Dis Dis NNP cord-329200-o5hxpl8f 50 4 2020 2020 CD cord-329200-o5hxpl8f 50 5 ; ; : cord-329200-o5hxpl8f 50 6 published publish VBN cord-329200-o5hxpl8f 50 7 online online JJ cord-329200-o5hxpl8f 50 8 Sept Sept NNP cord-329200-o5hxpl8f 50 9 23 23 CD cord-329200-o5hxpl8f 50 10 . . . cord-329200-o5hxpl8f 51 1 https://doi.org/10.1016/S1473-3099(20)30634-4 https://doi.org/10.1016/s1473-3099(20)30634-4 RB cord-329200-o5hxpl8f 51 2 . . . cord-329200-o5hxpl8f 52 1 Severe severe JJ cord-329200-o5hxpl8f 52 2 acute acute JJ cord-329200-o5hxpl8f 52 3 respiratory respiratory JJ cord-329200-o5hxpl8f 52 4 syndrome syndrome NN cord-329200-o5hxpl8f 52 5 coronavirus coronavirus NN cord-329200-o5hxpl8f 53 1 2−specific 2−specific CD cord-329200-o5hxpl8f 53 2 antibody antibody NN cord-329200-o5hxpl8f 53 3 responses response NNS cord-329200-o5hxpl8f 53 4 in in IN cord-329200-o5hxpl8f 53 5 coronavirus coronavirus NN cord-329200-o5hxpl8f 53 6 disease disease NN cord-329200-o5hxpl8f 53 7 patients patient NNS cord-329200-o5hxpl8f 53 8 Safety Safety NNP cord-329200-o5hxpl8f 53 9 and and CC cord-329200-o5hxpl8f 53 10 immunogenicity immunogenicity NN cord-329200-o5hxpl8f 53 11 of of IN cord-329200-o5hxpl8f 53 12 the the DT cord-329200-o5hxpl8f 53 13 ChAdOx1 ChAdOx1 NNP cord-329200-o5hxpl8f 53 14 nCoV-19 ncov-19 CD cord-329200-o5hxpl8f 53 15 vaccine vaccine NN cord-329200-o5hxpl8f 53 16 against against IN cord-329200-o5hxpl8f 53 17 SARS SARS NNP cord-329200-o5hxpl8f 53 18 - - HYPH cord-329200-o5hxpl8f 53 19 CoV-2 CoV-2 NNP cord-329200-o5hxpl8f 53 20 : : : cord-329200-o5hxpl8f 53 21 a a DT cord-329200-o5hxpl8f 53 22 preliminary preliminary JJ cord-329200-o5hxpl8f 53 23 report report NN cord-329200-o5hxpl8f 53 24 of of IN cord-329200-o5hxpl8f 53 25 a a DT cord-329200-o5hxpl8f 53 26 phase phase NN cord-329200-o5hxpl8f 53 27 1/2 1/2 CD cord-329200-o5hxpl8f 53 28 , , , cord-329200-o5hxpl8f 53 29 single single JJ cord-329200-o5hxpl8f 53 30 - - HYPH cord-329200-o5hxpl8f 53 31 blind blind JJ cord-329200-o5hxpl8f 53 32 , , , cord-329200-o5hxpl8f 53 33 randomised randomised JJ cord-329200-o5hxpl8f 53 34 controlled control VBN cord-329200-o5hxpl8f 53 35 trial trial NN cord-329200-o5hxpl8f 53 36 Convalescent convalescent JJ cord-329200-o5hxpl8f 53 37 plasma plasma NN cord-329200-o5hxpl8f 53 38 therapy therapy NN cord-329200-o5hxpl8f 53 39 for for IN cord-329200-o5hxpl8f 53 40 the the DT cord-329200-o5hxpl8f 53 41 treatment treatment NN cord-329200-o5hxpl8f 53 42 of of IN cord-329200-o5hxpl8f 53 43 patients patient NNS cord-329200-o5hxpl8f 53 44 with with IN cord-329200-o5hxpl8f 53 45 COVID-19 COVID-19 NNP cord-329200-o5hxpl8f 53 46 : : : cord-329200-o5hxpl8f 53 47 Assessment assessment NN cord-329200-o5hxpl8f 53 48 of of IN cord-329200-o5hxpl8f 53 49 methods method NNS cord-329200-o5hxpl8f 53 50 available available JJ cord-329200-o5hxpl8f 53 51 for for IN cord-329200-o5hxpl8f 53 52 antibody antibody NN cord-329200-o5hxpl8f 53 53 detection detection NN cord-329200-o5hxpl8f 53 54 and and CC cord-329200-o5hxpl8f 53 55 their -PRON- PRP$ cord-329200-o5hxpl8f 53 56 correlation correlation NN cord-329200-o5hxpl8f 53 57 with with IN cord-329200-o5hxpl8f 53 58 neutralising neutralise VBG cord-329200-o5hxpl8f 53 59 antibody antibody NN cord-329200-o5hxpl8f 53 60 levels level NNS cord-329200-o5hxpl8f 54 1 Convalescent convalescent JJ cord-329200-o5hxpl8f 54 2 plasma plasma NN cord-329200-o5hxpl8f 54 3 therapy therapy NN cord-329200-o5hxpl8f 54 4 for for IN cord-329200-o5hxpl8f 54 5 the the DT cord-329200-o5hxpl8f 54 6 treatment treatment NN cord-329200-o5hxpl8f 54 7 of of IN cord-329200-o5hxpl8f 54 8 patients patient NNS cord-329200-o5hxpl8f 54 9 with with IN cord-329200-o5hxpl8f 54 10 COVID-19 COVID-19 NNP cord-329200-o5hxpl8f 54 11 : : : cord-329200-o5hxpl8f 54 12 assessment assessment NN cord-329200-o5hxpl8f 54 13 of of IN cord-329200-o5hxpl8f 54 14 methods method NNS cord-329200-o5hxpl8f 54 15 available available JJ cord-329200-o5hxpl8f 54 16 for for IN cord-329200-o5hxpl8f 54 17 antibody antibody NN cord-329200-o5hxpl8f 54 18 detection detection NN cord-329200-o5hxpl8f 54 19 and and CC cord-329200-o5hxpl8f 54 20 their -PRON- PRP$ cord-329200-o5hxpl8f 54 21 correlation correlation NN cord-329200-o5hxpl8f 54 22 with with IN cord-329200-o5hxpl8f 54 23 neutralising neutralise VBG cord-329200-o5hxpl8f 54 24 antibody antibody NN cord-329200-o5hxpl8f 54 25 levels level NNS cord-329200-o5hxpl8f 55 1 SARS SARS NNP cord-329200-o5hxpl8f 55 2 - - HYPH cord-329200-o5hxpl8f 55 3 CoV-2 CoV-2 NNP cord-329200-o5hxpl8f 55 4 infection infection NN cord-329200-o5hxpl8f 55 5 induces induce VBZ cord-329200-o5hxpl8f 55 6 robust robust JJ cord-329200-o5hxpl8f 55 7 , , , cord-329200-o5hxpl8f 55 8 neutralizing neutralize VBG cord-329200-o5hxpl8f 55 9 antibody antibody NN cord-329200-o5hxpl8f 55 10 responses response NNS cord-329200-o5hxpl8f 55 11 that that WDT cord-329200-o5hxpl8f 55 12 are be VBP cord-329200-o5hxpl8f 55 13 stable stable JJ cord-329200-o5hxpl8f 55 14 for for IN cord-329200-o5hxpl8f 55 15 at at RB cord-329200-o5hxpl8f 55 16 least least RBS cord-329200-o5hxpl8f 55 17 three three CD cord-329200-o5hxpl8f 55 18 months month NNS cord-329200-o5hxpl8f 55 19 Human human JJ cord-329200-o5hxpl8f 55 20 coronavirus coronavirus NN cord-329200-o5hxpl8f 55 21 NL63 NL63 NNP cord-329200-o5hxpl8f 55 22 molecular molecular JJ cord-329200-o5hxpl8f 55 23 epidemiology epidemiology NN cord-329200-o5hxpl8f 55 24 and and CC cord-329200-o5hxpl8f 55 25 evolutionary evolutionary JJ cord-329200-o5hxpl8f 55 26 patterns pattern NNS cord-329200-o5hxpl8f 55 27 in in IN cord-329200-o5hxpl8f 55 28 rural rural JJ cord-329200-o5hxpl8f 55 29 coastal coastal JJ cord-329200-o5hxpl8f 55 30 Kenya Kenya NNP cord-329200-o5hxpl8f 55 31 Longitudinal Longitudinal NNP cord-329200-o5hxpl8f 55 32 analysis analysis NN cord-329200-o5hxpl8f 55 33 of of IN cord-329200-o5hxpl8f 55 34 clinical clinical JJ cord-329200-o5hxpl8f 55 35 serology serology NN cord-329200-o5hxpl8f 55 36 assay assay NN cord-329200-o5hxpl8f 55 37 performance performance NN cord-329200-o5hxpl8f 55 38 and and CC cord-329200-o5hxpl8f 55 39 neutralising neutralise VBG cord-329200-o5hxpl8f 55 40 antibody antibody NN cord-329200-o5hxpl8f 55 41 levels level NNS cord-329200-o5hxpl8f 55 42 in in IN cord-329200-o5hxpl8f 55 43 COVID19 COVID19 NNP cord-329200-o5hxpl8f 55 44 convalescents convalescent VBZ cord-329200-o5hxpl8f 55 45 Clinical clinical JJ cord-329200-o5hxpl8f 55 46 and and CC cord-329200-o5hxpl8f 55 47 immunological immunological JJ cord-329200-o5hxpl8f 55 48 assessment assessment NN cord-329200-o5hxpl8f 55 49 of of IN cord-329200-o5hxpl8f 56 1 asymptomatic asymptomatic JJ cord-329200-o5hxpl8f 56 2 SARS SARS NNP cord-329200-o5hxpl8f 56 3 - - HYPH cord-329200-o5hxpl8f 56 4 CoV-2 CoV-2 NNP cord-329200-o5hxpl8f 56 5 infections infection NNS cord-329200-o5hxpl8f 56 6 Distinct distinct JJ cord-329200-o5hxpl8f 56 7 early early JJ cord-329200-o5hxpl8f 56 8 serological serological JJ cord-329200-o5hxpl8f 56 9 signatures signature NNS cord-329200-o5hxpl8f 56 10 track track VBP cord-329200-o5hxpl8f 56 11 with with IN cord-329200-o5hxpl8f 56 12 SARS SARS NNP cord-329200-o5hxpl8f 56 13 - - HYPH cord-329200-o5hxpl8f 56 14 CoV-2 CoV-2 NNP cord-329200-o5hxpl8f 56 15 survival survival NN