id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-303262-grrd6jmt	Tournier, Jean-Nicolas	Pandemic Legion History More Complex than Previously Thought	2020-10-09		.txt	text/plain	699	34	47	Morens and colleagues describe in the "early pandemic history" section the story of pathogens emerging around 12,000 years ago at the time of Neolithic agricultural revolution. As such, diseases such as "measles, smallpox, tuberculosis (TB), [and] gastric cancer (caused by Helicobacter pylori)" are cited as consequences of "conditions of intense human-animal proximity and environmental alterations." This assertion of the dating of the origin of these aforementioned pathogens is partially misleading. Both viruses (i.e., those causing measles and smallpox) emerged probably much later, while Mycobacterium tuberculosis and Helicobacter pylori started their association with humans before the agricultural revolution. For smallpox, the exact date of divergence of variola virus (VARV) from a zoonotic strain is more disputed, as molecular data gave an estimation of emergence for the most recent common ancestor between the 16th and the 17th century, while skin lesions seen in the mummy of Ramses V, who died in 1157 BCE, suggested earlier interactions (6) .	./cache/cord-303262-grrd6jmt.txt	./txt/cord-303262-grrd6jmt.txt