id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-289049-4ozwhcyi	Roncati, Luca	Renin-angiotensin system: The unexpected flaw inside the human immune system revealed by SARS-CoV-2	2020-03-21		.txt	text/plain	383	27	44	title: Renin-angiotensin system: The unexpected flaw inside the human immune system revealed by SARS-CoV-2 Medical Hypotheses journal homepage: www.elsevier.com/locate/mehy Renin-angiotensin system: The unexpected flaw inside the human immune system revealed by SARS-CoV-2 In humans the renin-angiotensin system is the hormone system which regulates blood pressure and vascular resistances, as well as electrolytic balance; within this important system, the angiotensinconverting enzyme (ACE), present on the surface of vascular endothelial cells, in particular those of the lungs, is deputed to the conversion of angiotensin I to angiotensin II (AII), a potent vasoconstrictive peptide [1] . In addition, homologous ACE2 receptors have been identified on the oral mucosa, in type-II pneumocytes, along the intestine and on the kidney and heart endothelia [1, 2] ; these receptors have been found overexpressed in course of ACE inhibitors and AII receptor antagonists administration in murine models [3, 4] . Angiotensin-converting enzyme 2-a new cardiac regulator Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target Upregulation of angiotensin-converting enzyme (ACE) 2 in hepatic fibrosis by ACE inhibitors	./cache/cord-289049-4ozwhcyi.txt	./txt/cord-289049-4ozwhcyi.txt