id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-298183-cisrvghj	Fredricks, David N	The infectious aetiology of disease: the search for new agents	2005-03-01		.txt	text/plain	1311	84	42	The hypothesis that a disease has an infectious cause is supported by: clinical features (similar to those of known infectious diseases, e.g. fever, leucocytosis), epidemiology (case clustering in time or location), histology (inflammation of affected tissues, e.g. granulomata) or characteristic microbial structures, treatment (clinical response to antimicrobial treatment), and prevention of disease by vaccines targeting microbial antigens. Many of the recently discovered microbial pathogens were identified by detecting their unique nucleic acid sequences in tissues. A unique 16S rDNA sequence was detected in the tissues of three patients with bacillary angiomatosis but not in control tissues, identifying a bacterium in the Bartonella genus as a cause of a the disease. Several sequence-based approaches to pathogen discovery have yielded novel microbes that cause human disease. Future attempts to identify novel microbes associated with human disease may use other sequence-based approaches. Future attempts to identify novel microbes associated with human disease may use other sequence-based approaches.	./cache/cord-298183-cisrvghj.txt	./txt/cord-298183-cisrvghj.txt