id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-331504-b68y9hxw	Piotrowska, Dorota G.	New Isoxazolidine-Conjugates of Quinazolinones—Synthesis, Antiviral and Cytostatic Activity	2016-07-22		.txt	text/plain	4306	358	63	Our synthetic strategy to compounds trans-11/cis-11 relies on the 1,3-dipolar cycloaddition of N-methyl-C-(diethoxyphosphoryl)nitrone 12 [36] with 2-vinyl-3H-quinazolin-4-ones 13 substituted at N3 (Scheme 1). Our synthetic strategy to compounds trans-11/cis-11 relies on the 1,3-dipolar cycloaddition of N-methyl-C-(diethoxyphosphoryl)nitrone 12 [36] with 2-vinyl-3H-quinazolin-4-ones 13 substituted at N3 (Scheme 1). Our synthetic strategy to compounds trans-11/cis-11 relies on the 1,3-dipolar cycloaddition of N-methyl-C-(diethoxyphosphoryl)nitrone 12 [36] with 2-vinyl-3H-quinazolin-4-ones 13 substituted at N3 (Scheme 1). However, attempts to isolate pure diastereoisomers were fruitful for trans-11a The relative configurations of isoxazolidines trans-11a and cis-11a were established based on our previous studies on stereochemistry of cycloaddition of N-methyl-C-(diethoxyphosphoryl)nitrone (12) with various vinyl aryls [39, 40] since similar 1 H-NMR spectral patters for the respective series of trans-and cis-isoxazolidines were observed. After incubation at 37˝C for two (L1210), three (CEM) or four (HeLa) days, the cell number was determined of isoxazolidine-containing quinazolinones trans-11 and cis-11 have been synthesised from N-methyl-C-diethoxyphosphorylnitrone (12) and the respective N3-substituted 2-vinyl-quinazolin-ones 13 via the 1,3-dipolar cycloaddition.	./cache/cord-331504-b68y9hxw.txt	./txt/cord-331504-b68y9hxw.txt