id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-009326-dvhkk405	Lee, Jae Min	Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation	2020-03-14		.txt	text/plain	6438	359	51	title: Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation PRE inhibited TNF-α-induced NF-κB transcriptional activity in the NF-κB luciferase assay and pro-inflammatory genes' expression by blocking phosphorylation of IκB and NF-κB in 3T3-L1 adipocytes, which were mediated by activating AMPK. Ten-week-high fat diet (HFD)-fed C57BL6 male mice treated with PRE had improved glucose intolerance and decreased inflammation in adipose tissue, as indicated by reductions in NF-κB phosphorylation and pro-inflammatory genes' expression. To investigate the effects of PRE on inflammation, we first tested NF-κB transcriptional activity of TPRE because NF-κB is an essential regulator of pro-inflammatory response ( Figure S1 ). Together, these results strongly suggest that PRE suppresses TNF-α-mediated pro-inflammatory gene expression by activating AMPK. Together, these results strongly suggest that PRE suppresses TNF-α-mediated pro-inflammatory gene expression by activating AMPK.	./cache/cord-009326-dvhkk405.txt	./txt/cord-009326-dvhkk405.txt