id author title date pages extension mime words sentences flesch summary cache txt cord-252584-pcp1i0vb Troesch, Barbara Expert Opinion on Benefits of Long-Chain Omega-3 Fatty Acids (DHA and EPA) in Aging and Clinical Nutrition 2020-08-24 .txt text/plain 11710 535 41 However, this was a very small study and it has also been suggested that olive oil, which was used as a placebo, may have a protective effect for Alzheimer's disease [64] and might therefore have masked the effect of the supplementation with omega-3 LCPUFAs. Similarly, an intervention comparing 200 mg EPA plus 500 mg DHA daily for 24 months compared to olive oil did not find an effect on the California Verbal Learning Test in cognitively healthy older adults (mean age 75 years) [65] . Based on evidence from different systematic reviews [143, [154] [155] [156] [157] , the ESPEN guidelines for nutrition in cancer patients state "in patients with advanced cancer undergoing chemotherapy and at risk of weight loss or malnourished, we suggest to use supplementation with long-chain omega-3 fatty acids or fish oil to stabilize or improve appetite, food intake, lean body mass and body weight" but the recommendation is graded as weak and the level of evidence as low [158] . ./cache/cord-252584-pcp1i0vb.txt ./txt/cord-252584-pcp1i0vb.txt