id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-299731-sis9952k	Mehmel, Mario	Nicotinamide Riboside—The Current State of Research and Therapeutic Uses	2020-05-31		.txt	text/plain	10103	512	38	Oral supplementation with NR has been shown to increase NAD + levels in multiple tissues, along with increased SIRT activity [10, 11] , improved mitochondrial function [37] , and regenerative potential of stem cells [38] . In mice models, NR can increase NAD + metabolism and thereby improve glucose tolerance, reduce weight gain, and exhibit neuroprotective effects against diabetic neuropathy and liver steatosis [41] . NAD + precursor supplementation also has the potential to protect against adverse cardiac remodeling by additional mechanisms of activating SIRTs (Table 2 ) and maintaining Ca 2+ homeostasis [67] . Via SIRT3 activation, a NR-induced increase in NAD + levels can have additional beneficial and possible therapeutic effects. CR life-prolonging effects may partly be mediated via increased sirtuin function, while the requirement of NAD + for their activity suggests a possible connection between aging and metabolism.	./cache/cord-299731-sis9952k.txt	./txt/cord-299731-sis9952k.txt