id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-333317-oai67igl	Efremova, Agrafena	Biomarkers of Browning in Cold Exposed Siberian Adults	2020-07-22		.txt	text/plain	4645	230	47	Using RT-qPCR, we evaluated the peripheral blood mononuclear cells (PBMC) expression profile of regulators of BAT activity (CIDEA, PRDM16), white adipocytes browning (HOXC9 and SLC27A1), and fatty acid β-oxidation (CPT1A) in 150 Siberian healthy miners living at extremely cold temperatures compared to 29 healthy subjects living in thermoneutral conditions. Studies by Palou and colleagues conducted on female rats demonstrated that the expression of regulators of BAT activity (Cidea, Prdm16), WAT browning (Hoxc9 and Slc27a1), and fatty acid β-oxidation (Cpt1a) in both tissues, correlates with the expression of the same modulators in the peripheral blood mononuclear cells (PBMC) upon cold stimulation [19] . This is the first study investigating the expression of browning, beige, and fatty acids utilization regulators in the PBMC of human subjects chronically exposed to extremely cold temperatures compared to controls living in thermoneutral conditions. Cold-exposed subjects enrolled in our study expressed higher levels of the beiging's marker HOXC9 and lower amounts of the brown adipocytes' marker CIDEA compared to controls.	./cache/cord-333317-oai67igl.txt	./txt/cord-333317-oai67igl.txt