id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-337849-tyabf12r	Greiller, Claire L.	Modulation of the Immune Response to Respiratory Viruses by Vitamin D	2015-05-29		.txt	text/plain	9495	434	32	Background: Vitamin D deficiency has been shown to be independently associated with increased risk of viral acute respiratory infection (ARI) in a number of observational studies, and meta-analysis of clinical trials of vitamin D supplementation for prevention of ARI has demonstrated protective effects. Key findings: Vitamin D metabolites do not consistently influence replication or clearance of rhinovirus, respiratory syncytial virus (RSV) or influenza A virus in human respiratory epithelial cell culture, although they do modulate expression and secretion of type 1 interferon, chemokines including CXCL8 and CXCL10 and pro-inflammatory cytokines, such as TNF and IL-6. Numerous studies have demonstrated the role the 1,25(OH)2D-ligated VDR plays in binding to a VDRE in the promoter of the cathelicidin gene to enhance hCAP-18 production [116] [117] [118] [119] , thus suggesting a potential mechanism by which vitamin D may enhance innate immunity to respiratory infections.	./cache/cord-337849-tyabf12r.txt	./txt/cord-337849-tyabf12r.txt